Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"LC-MS profiling and multi-target mechanistic insights of Hibiscus rosa-sinensis in diabetes: Network pharmacology, molecular docking, MD simulation, PCA, and in-vitro α-amylase inhibition","authors":"Shankar Thapa ,&nbsp;Sharvendra Nath Maurya ,&nbsp;Kavya Manjunath ,&nbsp;Ammar A․Razzak Mahmood ,&nbsp;Kalpana Devi ,&nbsp;Shithin Ann Varghese ,&nbsp;Ashish Lamsal ,&nbsp;Binaya Tamang ,&nbsp;Mahalakshmi Suresha Biradar","doi":"10.1016/j.prmcm.2025.100636","DOIUrl":"10.1016/j.prmcm.2025.100636","url":null,"abstract":"<div><h3>Background</h3><div><em>Hibiscus rosa-sinensis</em> Linn. (Zhū Jǐn Huā), known in Traditional Chinese Medicine (TCM) as Dà Hóng Huā, has been widely used for its cooling, detoxifying, and anti-inflammatory properties. It is a medicinal plant traditionally used for managing diabetes, yet its multi-target mechanisms remain largely unexplored. This study aimed to investigate the anti-diabetic potential of <em>H. rosa-sinensis</em> through LC-MS-based phytochemical profiling, network pharmacology, molecular docking, molecular dynamics (MD) simulations, principal component analysis (PCA), and <em>in vitro</em> α-amylase inhibition assay.</div></div><div><h3>Methods</h3><div>LC-MS analysis was performed to identify bioactive compounds present in the methanolic extract of <em>H. rosa-sinensis</em>. Identified compounds were subjected to network pharmacology analysis to predict potential diabetes-related protein targets. Key compound-target interactions were evaluated using molecular docking (AutoDock Vina v1.2.0), followed by 100 ns MD simulations to assess structural stability and binding dynamics. PCA and free energy landscape (FEL) analyses were conducted to examine conformational behaviour. Finally, <em>in vitro</em> α-amylase inhibition was tested to validate the hypoglycaemic potential.</div></div><div><h3>Results</h3><div>Quercetin demonstrated strong binding affinities with PTK2 (–8.2 kcal/mol), SRC (–9.2 kcal/mol), and α-amylase (–8.9 kcal/mol), suggesting its multi-target action in diabetes. MD simulation confirmed the structural stability of all three complexes over 100 ns, supported by consistent RMSD and favourable interaction profiles. The PCA and FEL analyses showed minimal conformational fluctuations and energetically favourable states. The <em>in vitro</em> α-amylase inhibition assay further validated the antidiabetic potential, with an IC₅₀ value of 107.75 µg/mL for the <em>H. rosa-sinensis</em> flower extract.</div></div><div><h3>Conclusion</h3><div>This integrative study provides strong evidence for the multi-target antidiabetic potential of <em>Hibiscus rosa-sinensis</em>, primarily attributed to quercetin and its derivatives. The findings highlight stable interactions with key diabetic targets and demonstrate significant α-amylase inhibition, supporting the traditional use of <em>H. rosa-sinensis</em> as a complementary therapy for diabetes management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the progress of the traditional Chinese medicine \"Duhuo-Qianghuo\" in targeting the PI3K-AKT pathway to alleviate knee osteoarthritis based on bioinformatics","authors":"Likang Wang ,&nbsp;Minqi Zhu ,&nbsp;Rujie Zhuang","doi":"10.1016/j.prmcm.2025.100638","DOIUrl":"10.1016/j.prmcm.2025.100638","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aims to explore how the traditional Chinese medicine \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" targets the PI3K-AKT signaling pathway to alleviate knee osteoarthritis using network pharmacology, molecular docking technology, and experimental validation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Active ingredients and target genes related to \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" and knee osteoarthritis were retrieved from relevant databases.Overlapping data were used to develop a protein-protein interaction (PPI) network model. Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, were performed using the DAVID tool. The identification of core active components and target genes was based on their interaction intensity within the PPI network.These identified components and targets were subjected to molecular docking analysis via AutoDockTools-1.5.7.Furthermore, the therapeutic effects of \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" in reducing cartilage degradation and inhibiting inflammatory responses were assessed using a knee osteoarthritis mouse model.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;\"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" comprises 65 bioactive components and 622 associated targets. Through the integration of several databases, 5215 target genes related to knee osteoarthritis were identified, among which 304 were shared between datasets. The primary active compounds implicated in the therapeutic effects of \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" include &lt;em&gt;homostephanoline, xanthoxyletin&lt;/em&gt;, a&lt;em&gt;ngelicone&lt;/em&gt;, and &lt;em&gt;ostruthin&lt;/em&gt;. Critical therapeutic targets encompass tumor necrosis factor (TNF), protein kinase B1 (AKT1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), interleukin-1β (IL-1β), and albumin (ALB). GO functional enrichment analysis revealed 1231 results, comprising 917 biological processes, 106 cellular components, and 208 molecular functions.KEGG pathway enrichment analysis identified 176 pathways, with the top 20 ranked by P-values and presented in bubble plots. Molecular docking studies demonstrated robust binding affinities between &lt;em&gt;homostephanoline, xanthoxyletin&lt;/em&gt;, and targets such as AKT1 and TNF. Additionally, \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" granules showed partial restorative effects on cartilage damage and a reduction in inflammatory markers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study offers a preliminary exploration of the mechanisms underlying the therapeutic effects of \"&lt;em&gt;Du huo-Qiang huo&lt;/em&gt;\" in managing knee osteoarthritis. Through an analysis of its diverse components, molecular targets, and related pathways, the findings highlight that pivotal active compounds, such as &lt;em&gt;homostephanoline&lt;/em&gt; and &lt;em&gt;xanthoxyletin&lt;/em&gt;, engage with critical targets like TNF and AKT1.These molecular interactions modulate the PI3K-AKT signaling pathway, promoting cartilage regeneration and mitigating inflammatory responses,which collectively contribute to its therap","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Dang Gui Yinzi combined with topical medications for psoriasis: A systematic review and meta-analysis","authors":"Li Liang ,&nbsp;Zhaohui Hou ,&nbsp;Lian Zhang ,&nbsp;Ying Sun","doi":"10.1016/j.prmcm.2025.100637","DOIUrl":"10.1016/j.prmcm.2025.100637","url":null,"abstract":"<div><h3>Introduction</h3><div>Psoriasis, a chronic inflammatory skin disease, is traditionally classified as \"leukoderma\" or \"tinea cruris\" in Traditional Chinese Medicine (TCM). Dang Gui Yinzi (Dang Gui Drink, DGD), a classic TCM formula, is prescribed to nourish blood, dispel wind, and alleviate dryness, aligning with TCM pathogenesis theories of psoriasis.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on the efficacy and safety of Dang Gui Drink combined with topical medications for psoriasis was conducted. This meta-analysis was performed based on a protocol registered in PROSPERO (CRD42025637050). The outcomes were reported as mean differences (MDs) with corresponding 95 % confidence intervals (CI) or risk ratio (RR) with 95 % CI.</div></div><div><h3>Results</h3><div>A total of 13 RCTs, involving 918 participants, were included. The MD for Psoriasis Area and Severity Index (PASI) score improvement was −3.26 (95 % CI [−4.13 to −2.39]), indicating a significant improvement in the combination therapy group compared to the control group. The RR for clinical efficacy was 1.27 (95 % CI [1.19 to 1.36]), suggesting higher efficacy in the combination therapy group. There was no significant difference in the incidence of adverse events (RR = 0.51, 95 % CI [0.16 to 1.62])<em>.</em></div></div><div><h3>Discussion</h3><div>Dang Gui Drink combined with topical therapies demonstrates enhanced efficacy for psoriasis with a favorable safety profile. However, further high-quality RCTs are needed to enhance the robustness and reliability of these findings.</div><div>© 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of Global Science and Technology Forum Pte Ltd</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100637"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine in cardiovascular therapy: bridging modern pharmacology with the traditional Chinese botanicals Huanglian (黄连), Huangbai (黄柏), Amur Cork Tree (黄檗), and Gong Lao Mu (亮叶十大功劳)","authors":"Seema Sharma,&nbsp;Sampat Singh Tanwar","doi":"10.1016/j.prmcm.2025.100635","DOIUrl":"10.1016/j.prmcm.2025.100635","url":null,"abstract":"<div><h3>Purpose</h3><div><strong>.</strong> This review aims to explore the current pharmacological evidence supporting the use of berberine, a bioactive alkaloid, in cardiovascular therapy, and to bridge this modern understanding with its traditional use in Chinese medicine through the botanicals <em>Huanglian (黄连), Huangbai (黄柏), Amur Cork Tree (黄檗), and Gong Lao Mu (亮叶十大功劳).</em></div></div><div><h3>Method</h3><div>We performed a comprehensive literature search across PubMed, CNKI, Web of Science, Scopus, ScienceDirect, and Google Scholar (inception to May 2025) to identify studies on berberine's (TCM) use in cardiovascular disorders. Our search used keywords like \"Berberine,\" \"Cardiovascular therapy,\" \"TCM,\" and specific botanical names (e.g., \"Huanglian\"). We aimed to understand berberine's effectiveness and its molecular mechanisms in cardiovascular health. From 500 initial articles, we selected 250 relevant to our study on berberine's efficacy in various cardiovascular outcomes.</div></div><div><h3>Results</h3><div>Modern pharmacological studies demonstrate that berberine exhibits significant cardiovascular benefits through multiple mechanisms of action. These include lipid-lowering effects by upregulating LDL receptors and inhibiting PCSK9, antihypertensive effects via vasodilation and modulation of the renin-angiotensin-aldosterone system, antiarrhythmic properties by affecting ion channels, and improvement in cardiac function in heart failure models. Traditionally, Huanglian, Huangbai, Amur Cork Tree, and Gong Lao Mu, all rich sources of berberine, have been used in Traditional Chinese Medicine (TCM) to treat symptoms aligning with cardiovascular disorders, such as palpitations, chest distress, and edema. The modern pharmacological findings largely corroborate these traditional applications, highlighting berberine as a key active component responsible for the observed therapeutic effects.</div></div><div><h3>Conclusion</h3><div>Berberine holds significant promise as a therapeutic agent in cardiovascular disease, supported by both modern pharmacological investigations and its long history of use in TCM through berberine-rich botanicals like Huanglian, Huangbai, Amur Cork Tree, and Gong Lao Mu. Further well-designed clinical trials are warranted to fully elucidate the therapeutic potential and optimize the clinical application of berberine and these traditional herbs in the prevention and management of various cardiovascular conditions.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the anti-membranous glomerulonephritis mechanism of Acanthopanacis Cortex using network pharmacology and experimental verification","authors":"Shan Liu ,&nbsp;Ziye Dong ,&nbsp;Hongyan Gu ,&nbsp;Yamin Xiong ,&nbsp;Wei Su ,&nbsp;Fei Cao","doi":"10.1016/j.prmcm.2025.100632","DOIUrl":"10.1016/j.prmcm.2025.100632","url":null,"abstract":"<div><h3>Introduction</h3><div>Membranous glomerulonephritis (MGN), an autoimmune kidney disease, often progresses to renal failure. Current treatments have significant side effects, highlighting the need for alternatives. <em>Acanthopanacis</em> Cortex (AC, <em>Wujiapi</em>), a Traditional Chinese Medicine, exhibits anti-inflammatory and antioxidant properties, but its mechanisms in MGN are unclear. Using network pharmacology and cell experiments, this study investigates AC’s therapeutic potential in MGN.</div></div><div><h3>Methods</h3><div>AC constituents were sourced from literature and TCMSP, with targets predicted using PharmMapper and SwissTargetPrediction (OB ≥ 30 %, DL ≥ 0.18) and standardized via UniProt. MGN-related targets from DisGeNET and CTD were analyzed using Venn diagrams, Cytoscape networks, and STRING PPI, with enrichment via Metascape. Core compounds and targets were validated by molecular docking with AutoDock and PDB. RAW264.7 cells treated with AC, sesamin, and LPS were assessed for viability (MTT), NO production (Griess), COX-2/iNOS (Western blot), and ROS (DCFH-DA staining).</div></div><div><h3>Results</h3><div>15 bioactive compounds from AC, targeting 409 genes (109 linked to MGN), were analyzed, revealing key pathways via PPI, KEGG, and GO. Molecular docking confirmed strong compound-protein interactions. AC and sesamin (≤50 μg/mL/μM) reduced NO, inhibited COX-2/iNOS, and alleviated oxidative stress in LPS-induced inflammation without toxicity.</div></div><div><h3>Discussions</h3><div>TCM extracts like <em>Tripterygium wilfordii, Astragalus membranaceus</em>, and <em>Panax notoginseng</em> exhibit anti-inflammatory and kidney-protective effects, particularly in minimal change nephrotic syndrome (MGN). AC, derived from <em>P. notoginseng</em>, shows therapeutic promise in MGN models. Using network pharmacology, this study identified five key components in AC, including (-)-kaur-16-en-19-oic acid, acanthoic acid, sesamin, and β-sitosterol, which modulate pathways like PI3K-Akt, JAK-STAT, and MAPK, suggesting mechanisms for MGN treatment. Experimental validation confirmed AC’s anti-inflammatory effects in LPS-stimulated cells, reducing NO release, oxidative stress, and cytokines, supporting its efficacy in MGN.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100632"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry, pharmacological potential, and network-based insights of Eucommia ulmoides in traditional Chinese medicine","authors":"Suruchi,&nbsp;Mahima Tiwari,&nbsp;Ajay Kumar Gupta,&nbsp;Dipti Pal,&nbsp;Sanmati Kumar Jain","doi":"10.1016/j.prmcm.2025.100633","DOIUrl":"10.1016/j.prmcm.2025.100633","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Eucommia ulmoides</em> (EU) has been widely used in Traditional Chinese Medicine (TCM) for centuries, particularly for strengthening the liver and kidneys, supporting bone health, and managing hypertension. Although it has a lengthy application history, incorporating this substance into contemporary medical practices has been somewhat restricted. It comprises more than 200 identified compound including flavonoids, iridoids, lignans, phenolic acid, steroid<strong><em>,</em></strong> terpenoids, and carbohydrates etc. This review intends to consolidate the current knowledge of their pharmacological effects of <em>EU</em> and explore its prospective therapeutic advantages utilizing the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Many effective active components from TCMSP database were identified by researchers, based on profiles of drug-likeness (DL ≥ 0.18) and oral bioavailability (OB ≥ 30 %).</div></div><div><h3>Methods</h3><div>An extensive literature survey was done using multiple databases such as Google Scholar, PubMed, Springer Link, and Science Direct, to examine the phytoconstituents and pharmacological effects of EU. This article seeks to provide a summary of its primary chemical constituents and pharmacological activities associated with EU.</div></div><div><h3>Results</h3><div>EU, recognized as a traditional herbal remedy, has been employed for its various therapeutic potentials, including antihypertensive effects, anti-inflammatory, neuroprotective, hypoglycaemic effects, and hypolipidemic properties. Additionally, digestive benefits, hepatoprotective effects, antitumor activities, antioxidant activities, antimicrobial effects, immunomodulatory activities, and anti-osteoporosis effects were also reported by different researchers. Furthermore, it acts on the CNS, reducing inflammation, helping with Alzheimer's disease, and hypnotic and anticonvulsant traits. It also provides renal protective effects, anti-aging benefits, and anti-hyperuricemia properties.</div></div><div><h3>Discussion</h3><div>Experimental research supports certain pharmacological properties of EU, a traditional herbal medicine. However, further studies are necessary to fully understand its implications and therapeutic potential.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100633"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of terminalia chebula and coconut oil in acute lung injury: Bioactive compound analysis and histopathological evidence","authors":"Kamalakannan Solaiyappan ,&nbsp;Sowjanya Bandlamudi ,&nbsp;Lavanya Prathap ,&nbsp;Vaijayanthimala Ponnusamy ,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.prmcm.2025.100634","DOIUrl":"10.1016/j.prmcm.2025.100634","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are critical conditions involving severe lung inflammation and impaired gas exchange. They are often triggered by sepsis, pneumonia, or trauma. Current therapies mainly provide supportive care without addressing the root inflammatory causes. Natural compounds with anti-inflammatory properties are being explored as adjunct treatments. <em>Terminalia chebula</em> (Haritaki), a key medicinal plant in traditional Ayurvedic and Chinese medicine and virgin coconut oil are rich in bioactive known for their therapeutic and anti-inflammatory benefits.</div></div><div><h3>Materials &amp; Methods</h3><div>This study aimed to identify the bioactive compounds present in Haritaki using Gas Chromatography-Mass Spectrometry (GC–MS) analysis on an ethanol extract. The GC–MS analysis revealed 30 bioactive compounds, which were identified based on their retention times and peak areas. These compounds displayed promising pharmacological properties, suggesting their potential use in the development of novel drugs or as crude drugs.</div></div><div><h3>Results</h3><div>The study also investigated the therapeutic potential of <em>T. chebula</em> and coconut oil in a mouse model of ALI, a serious condition characterized by inflammation and impaired gas exchange, which often progresses to ARDS and is associated with high mortality rates. The histopathological analysis of lung tissues from mice indicated that the group pre-treated with <em>T. chebula</em> and coconut oil exhibited significant therapeutic benefits. This included a reduction in lung inflammation, improved tissue repair, and overall better histopathological outcomes.</div></div><div><h3>Conclusion</h3><div>These findings suggest that <em>T. chebula</em> and coconut oil, either independently or in combination, may have potential as therapeutic agents for conditions like ALI and ARDS, contributing to enhanced lung health and recovery.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100634"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the therapeutic potential of quercetin, a widely spread flavonoid, in the prevention and management of chronic and degenerative diseases through a modern Chinese medicine perspective","authors":"Issac V Cherian ,&nbsp;Abhishek Vijukumar ,&nbsp;Md Mustahidul Islam ,&nbsp;Janvi ,&nbsp;Akash Vikal","doi":"10.1016/j.prmcm.2025.100630","DOIUrl":"10.1016/j.prmcm.2025.100630","url":null,"abstract":"<div><h3>Introduction</h3><div>It is evident in Traditional Chinese Medicine that quercetin (QUE, 槲皮素, Húpísù) is present in many fruits, vegetables, and herbs, including Sophora japonica (槐花, Huáihuā) and Ginkgo biloba (银杏, Yínxìng). It is recognized for its protective antioxidant, anti-inflammatory, antidiabetic, antimicrobial, and immunomodulatory effects.</div></div><div><h3>Methods</h3><div>We looked for studies in PubMed, ScienceDirect, and Google Scholar from 2000 to 2025. The keywords we chose were “quercetin,” “chronic diseases,” “antioxidant,” “anti-inflammatory,” and “Traditional Chinese Medicine.” Findings on QUE’s drug interactions, problems figuring out its dosing, and its place in TCM were examined.</div></div><div><h3>Results</h3><div>QUE prevents some of the negative effects of ageing and chronic diseases by acting as an effective antioxidant. It controls inflammation by cutting back on TNF-α, IL-6, IL-1β, and by blocking NF-κB, MAPK, and PI3K/Akt pathways. QUE improves how the body uses insulin, supports the function of β-cells, and regulates sugar metabolism using AMPK and GLUT4. Tea tree oil acts against germs by rupturing membranes and prohibiting biofilm from forming. Ques presents itself as an enhancer of Treg cell differentiation and a way to decrease uncontrolled actions of the immune system in autoimmune disorders. Yet, its clinical application is not strong because it breaks down easily and has low bioavailability.</div></div><div><h3>Discussion</h3><div>Because QUE has a wide range of therapeutic effects, it is being used more often in treatments for ongoing and inflammatory health problems. Traditional Russian Medicine makes it clear that ancient ideas can be used with modern medical approaches. In the future, scientists should examine how to improve the delivery of QUE and validate its use in clinical trials.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100630"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of the treatment of acute pancreatitis with traditional Chinese medicine compound preparation","authors":"Xiao Teng ,&nbsp;Shanfeng Sheng ,&nbsp;Mingyuan Pan ,&nbsp;Yuyang Li ,&nbsp;Zheng Li","doi":"10.1016/j.prmcm.2025.100628","DOIUrl":"10.1016/j.prmcm.2025.100628","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute pancreatitis (AP), a prevalent gastrointestinal disorder characterized by pancreatic auto-digestion, currently lacks targeted therapeutic agents despite its clinical significance. In contemporary medical practice, traditional Chinese medicine (TCM) formulations have gained increasing clinical traction for AP management in China. This retrospective controlled trial systematically investigated the therapeutic potential of a novel compound herbal formulation, with a focused evaluation of its clinical efficacy and safety profile in the management of acute pancreatitis (AP).</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 363 acute pancreatitis (AP) patients, stratified into two cohorts: 235 patients receiving traditional Chinese medicine (TCM) intervention, and 128 patients allocated to the control group. Both cohorts received standardized therapeutic interventions upon hospitalization. Clinical parameters including time to first defecation, admission intra-abdominal pressure, C-reactive protein (CRP) levels, postoperative intra-abdominal pressure at 48-hour intervals, incidence of adverse reactions and complications, and prognostic outcomes were systematically monitored and recorded throughout the treatment course.</div></div><div><h3>Results</h3><div>The clinical investigation demonstrated that patients administered a TCM-based therapeutic regimen exhibited significantly accelerated time to first bowel movement compared with the control cohort following hospital admission (p&lt;0.001). Comparative analysis revealed no statistically significant intergroup differences in abdominal pressure reduction, C-reactive protein (CRP) levels, or clinical recovery status at baseline assessment. However, subsequent to 48 hours of therapeutic intervention, the TCM group demonstrated statistically superior reductions in both intra-abdominal pressure (p&lt;0.001) and serum CRP concentrations (p&lt;0.001) relative to conventional treatment recipients. Notably, the TCM intervention cohort exhibited a significantly lower incidence of adverse reactions and post-treatment complications (p&lt;0.001) .</div></div><div><h3>Conclusion</h3><div>The treatment group administered TCM, a Chinese herbal compound formulation, exhibited significantly superior clinical efficacy in multiple outcome measures compared to conventional therapy. Specifically, TCM demonstrated enhanced constipation relief, more substantial reduction in inflammatory markers, greater mitigation of intra-abdominal pressure, and lower incidence of adverse reactions during acute pancreatitis management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese phytopharmacology for gastritis - A systematic review of high-quality randomized controlled trials","authors":"Carla Cardiga ,&nbsp;Alexandre Constantino ,&nbsp;Catarina Fonseca ,&nbsp;Daniela Silva ,&nbsp;Isabel Teixeira ,&nbsp;Jorge Magalhães Rodrigues","doi":"10.1016/j.prmcm.2025.100631","DOIUrl":"10.1016/j.prmcm.2025.100631","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastritis is a highly prevalent condition, often lifelong, affecting a substantial portion of the global population. It is estimated that over half of all people experience some degree of chronic gastritis, representing hundreds of millions of individuals worldwide. This systematic review evaluates the efficacy and safety of Chinese phytopharmacological interventions for chronic gastritis, including atrophic and non-atrophic subtypes.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Cochrane Library, Embase, ScienceDirect, and EuropePMC up to November 2024. Only high-quality randomized controlled trials (RCTs) (Jadad score ≥3) were included. Data on characteristics, interventions, comparators, dosages, and key findings interventions were extracted and synthesized.</div></div><div><h3>Results</h3><div>Six RCTs involving 1,195 patients were included. For <em>Helicobacter pylori</em>-negative atrophic gastritis, <em>Piwei Peiyuan</em> prescription and <em>Yiwei Xiaoyu</em> granules significantly improved atrophy and intestinal metaplasia (e.g., <em>Piwei Peiyuan:</em> 64 % improvement in gastric angle atrophy, <em>p</em> = 0.034). In <em>H. pylori</em>-positive cases, <em>Weiwei</em> granules + quadruple therapy achieved higher eradication rates and better histological outcomes than conventional treatment alone. In non-atrophic gastritis, <em>Qirui Weishu</em> capsules led to greater symptom resolution than <em>Sanjiu Weitai</em> (<em>p</em> &lt; 0.01), and <em>Houtou Jianweiling</em> tablets were comparable to omeprazole in efficacy and safety.</div></div><div><h3>Conclusion</h3><div>High-quality evidence from RCTs indicates that several Chinese herbal formulations—such as <em>Piwei Peiyuan</em> prescription, <em>Yiwei Xiaoyu</em> granules, and <em>Qirui Weishu</em> capsules—are effective in alleviating symptoms and improving histopathological outcomes in chronic gastritis, with safety profiles comparable to conventional treatments. These findings support the clinical potential of Chinese phytopharmacology, particularly in improving histological outcomes and alleviating symptoms like epigastric pain and dyspepsia, as standalone or adjunctive therapy. However, these results should be interpreted with caution due to variations in dosing, limited placebo use, and short follow-up periods across studies</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}