Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease","authors":"Aracely Janneth Naranjo-Viteri ,&nbsp;Matías Jávega Cometto ,&nbsp;Matías Caverzan ,&nbsp;Leandro Gabriel Champarini ,&nbsp;María Paula Zunino ,&nbsp;Rogelio E. Abburra ,&nbsp;Claudia B. Hereñú ,&nbsp;Rosana Crespo","doi":"10.1016/j.prmcm.2025.100584","DOIUrl":"10.1016/j.prmcm.2025.100584","url":null,"abstract":"<div><h3>Introduction</h3><div>Essential oil (EO) of eucalyptus has been commonly used as a traditional Chinese medicine to treat illnesses such as influenza, dysentery and eczema, and it is widely used in the pharmaceutical industry. However, its neuroprotective effects have not been fully demonstrated. Given the rising prevalence of the neurodegenerative disorder, Parkinson's disease, in aging populations, this study aims to investigate the effect of Eucalyptus globulus EO (EuEO) in a rat Parkinson model induced by bilateral lesion with the neurotoxin, 6-hydroxydopamine (6-OHDA).</div></div><div><h3>Methods</h3><div>EuEO composition was determined by GC–MS. Wistar rats were treated with EuEO (25 mg/kg, i.p) for 36 days, and behavioral tests (Barnes maze, wire mesh ramp, and grip strength) were performed 18 days after 6-OHDA application. We evaluated tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the brain caudate-putamen unit; inflammatory cytokine (TNF-α, IL-6) expression in the hippocampus; liver, kidney, and gut histology; serum parameters; and hepatic lipid content.</div></div><div><h3>Results</h3><div>Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio.</div></div><div><h3>Discussion</h3><div>Although 1,8-cineole is a well-documented bioactive compound, further research is required to evaluate its potential synergistic or additive interactions with minor components. Our findings highlight the remarkable neuroprotective potential of EuEO and encourage further research of this very promising therapeutic alternative.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100584"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143224971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The knowledge mapping of traditional Chinese medicine for hepatocellular carcinoma: A bibliometric study","authors":"Wenya Pei ,&nbsp;Boyu Jiao ,&nbsp;Zexiong Chen ,&nbsp;Jingchun Zeng ,&nbsp;Yancheng Fu ,&nbsp;Zhanmou Liang ,&nbsp;Baoguo Sun ,&nbsp;Jingwen Ruan ,&nbsp;Shijun Zhang","doi":"10.1016/j.prmcm.2025.100581","DOIUrl":"10.1016/j.prmcm.2025.100581","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine is widely used as adjuvant therapy for hepatocellular carcinoma (HCC), but no relevant bibliometric study has comprehensively analyzed the available data.</div></div><div><h3>Methods</h3><div>To summarize the research landscape of traditional Chinese medicine (TCM) in relation to HCC over the past decade, publications on TCM and HCC from 2013 to 2023 were collected and analyzed using CiteSpace software.</div></div><div><h3>Results</h3><div>A total of 1,160 articles on TCM for HCC were included in the bibliometric analysis, with the most productive countries and institutions located in the Asia region. The analysis indicated that traditional Chinese medicine may enhance immunity and regulate the local tumor microenvironment through mechanisms involving DNA damage, cell cycle arrest, and apoptosis by signaling pathways.</div></div><div><h3>Discussion</h3><div>This study provides insights into the trends of traditional Chinese medicine for hepatocellular carcinoma, which may inform clinical practice and identify potential targets for further research. However, high-quality evidence-based research and rigorous mechanistic studies should be prioritized to explore new anticancer approaches.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100581"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143224974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic role of isoflavones from traditional medicine in the management of polycystic ovary syndrome","authors":"Ashwini Armarkar ,&nbsp;Prafulla Sabale ,&nbsp;Satyendra Prasad ,&nbsp;Vidya Sabale ,&nbsp;Lata Potey ,&nbsp;Dipti Masram","doi":"10.1016/j.prmcm.2025.100580","DOIUrl":"10.1016/j.prmcm.2025.100580","url":null,"abstract":"<div><h3>Introduction</h3><div>Polycystic ovary syndrome (PCOS) is a significant public health problem and one of the most common gynaecological and endocrine disorder.This condition affects an estimated 8–13 % of women of reproductive age worldwide. PCOS manifests as a group of symptoms, including oligomenorrhea, obesity, infertility, increased risk of diabetes, acne, and hirsutism. The etiology of PCOS involves a complex interplay of factors, including genetic predisposition, neuroendocrine dysregulation, contemporary lifestyle practices, and obesity. Numerous traditional chinese formulations have demonstrated success in mitigating PCOS symptoms and addressing its underlying causes.</div></div><div><h3>Methodology</h3><div>Online databases such as Google Scholar, PubMed, and ScienceDirect Library were employed to find literatures on “Polycystic ovary syndrome,” “Phytoestrogens,” “Pharmacokinetics of Isoflavones” Role of isoflavones in PCOS. considering articles published in the last 20 years to capture recent research.This review summarizes the scientific findings on traditional herbs rich in isoflavones and their bioactive components of the phytoestrogen class for the management of PCOS.</div></div><div><h3>Result</h3><div>Isoflavones, a subset of polyphenolic compounds, represent a prominent class of phytoestrogens. These secondary plant metabolites, which predominantly occur in the Fabaceae family, exhibit structural similarities to 17β-estradiol, and typically exist in conjugated forms. The estrogenic properties of isoflavone phytoconstituents, such as genistein, biochanin A, daidzein, puerarin, and formononetin, confer substantial therapeutic potential for PCOS management.</div></div><div><h3>Conclusion</h3><div>Despite their therapeutic potential, there is a paucity of data regarding the safety profile, clinical efficacy, and optimal treatment duration of isoflavones. Further investigations across various domains of isoflavone research are imperative to enhance the understanding of this complex field of study.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100580"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143224545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of extraction parameters and anti-hyperglycemic assessment of standardized extract from Santalum album L. leaves","authors":"Phan Thi Kim Phung ,&nbsp;Dang Ngoc Lam Binh ,&nbsp;Nguyen Thi Anh Thu ,&nbsp;Nguyen Van Ha ,&nbsp;Tran Thi Huyen ,&nbsp;Khuu Minh Hien ,&nbsp;Mai Huynh Nhu ,&nbsp;Ngo Kien Duc ,&nbsp;Le Minh Quan","doi":"10.1016/j.prmcm.2025.100577","DOIUrl":"10.1016/j.prmcm.2025.100577","url":null,"abstract":"<div><h3>Background</h3><div><em>Santalum album</em> (SA) L., also known as sandalwood, a habituated plant in Asia and China, is commonly used in traditional Chinese medicine to treat various diseases, including inflammation and diarrhea. It is a versatile tree with considerable commercial worth, primarily due to its exceptionally fragrant qualities. Although extensively studied worldwide for its pharmacological effects, research in Vietnam has yet to develop optimized extraction processes or investigate the biological activities of SA L. constituents.</div></div><div><h3>Aim of the study</h3><div>The objectives of this study were to establish standards, optimize extraction processes, and evaluate the hypoglycemic effects of extracts from the leaves of SA.</div></div><div><h3>Materials and methods</h3><div>The extraction parameters for vitexin and isovitexin were optimized using response surface methodology. Vitexin and isovitexin were quantified by ultra-high-performance liquid chromatography. The hypoglycemic effect of SA extract was assessed using a male Swiss albino mouse model.</div></div><div><h3>Results and discussion</h3><div>Quantification of vitexin and isovitexin in SA extract met the validation standards. The optimal extraction process involved refluxing at 66 °C for 180 min, using 70 % ethanol at a solvent-to-material ratio of 33:1 mL/g. Standardized extracts were developed using specified criteria for sensory properties, moisture, heavy metals, microbial limits, and compound identification. The SA extract contained 6.61 % vitexin and 4.47 % isovitexin (w/w). Safe oral SA doses of 1 and 2 g/kg were established, which improved body weight and blood glucose levels in rats with hyperglycemia.</div></div><div><h3>Conclusion</h3><div>These findings suggest that the optimized method is effective for the extraction of vitexin and isovitexin from SA L. leaves and that the plant may serve as a potential candidate for the development of a new natural anti-diabetic agent.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating network pharmacology and experimental validation to explore the mechanism of action of BushenQiangxin Formula for the treatment of chronic heart failure","authors":"Jinhua Pang ,&nbsp;Jiejun Hou ,&nbsp;Jinyi Chen ,&nbsp;Wenchu Zhao ,&nbsp;Tiantian Tang ,&nbsp;Taotao Li ,&nbsp;Ding Liu ,&nbsp;Jinkai Li ,&nbsp;Xuan Wang","doi":"10.1016/j.prmcm.2025.100579","DOIUrl":"10.1016/j.prmcm.2025.100579","url":null,"abstract":"<div><h3>Objective</h3><div>: To evaluate the mechanism of action of <strong>the BushenQiangxin (BSQX) formula</strong> in treating chronic heart failure (CHF) based on network pharmacology and experimental zoology.</div></div><div><h3>Methods</h3><div>: The targets and components of BSQX in CHF were assessed based on network pharmacology and data from the Gene Expression Omnibus (GEO) database. The drug–disease interaction network diagram was constructed, and the possible pathways affected by BSQX in CHF were analyzed. Molecular docking between the key components of BSQX and the key targets of CHF was performed using the Discovery Studio software. Finally, a CHF rat model was established. The serum interleukin (IL)-6 level was evaluated using the enzyme-linked immunosorbent assay in each rat group. The structural changes in the left ventricular myocardial tissues were observed via hematoxylin &amp; eosin staining, and the expression of cTnI, IL-17, and nuclear factor kappa B (NF-KB) proteins was measured via immunohistochemistry in the cardiac muscle tissue.</div></div><div><h3>Results</h3><div>: Network pharmacology and data from the GSE84796 database were used to screen 25 core targets of BSQX for CHF. The major signaling pathways, including the IL-17 signaling pathway, tumor necrosis factor signaling pathway, AGE-RAGE signaling pathway, which are associated with diabetic complications, lipid, and atherosclerosis were identified via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. The molecular docking results showed good binding between the core targets (IL6, MMP9, CCL2, and STAT1) and active compounds (such as quercetin, lignocerol, oleanolic acid, pentacosanoic acid, and isobetulinic acid). Hematoxylin &amp; eosin staining in animal experiments showed that BSQX could reduce the degree of inflammatory infiltration and fibrosis of cardiomyocytes in CHF to a certain extent. The enzyme-linked immunosorbent assay and immunohistochemistry showed that BSQX could effectively reduce the levels of IL-17, IL-6, cTnI, and NF-KB in chronic rats.</div></div><div><h3>Conclusion</h3><div>: In CHF treatment, the mechanism of BSQX can be related to the inhibition of IL-17, IL-6, cTnI, and NF-KB production, inflammatory cell infiltration, and the attenuation of myocardial injury based on network pharmacology and experimental animal studies. Moreover, its mechanism of action may function via the IL-17 signaling pathway.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginseng exhibits adaptogenic-like activity in mice exposed to hypoxic-anoxic stress through activation of antioxidant/BDNF protective mechanisms and inhibition of pro-inflammatory cytokines/NF-KB signaling pathways","authors":"James Olukayode Oni ,&nbsp;Divine Oluwaferanmi Oyenekan ,&nbsp;Yetunde Olamide Olayemi ,&nbsp;Osarugue Christabel Irabor ,&nbsp;Precious Ogbuji ,&nbsp;McCarthy Oritseweyinmi Tova ,&nbsp;Paul Ademola Adeleke ,&nbsp;Gbemisayo Adetomiwa Abbas ,&nbsp;Solomon Umukoro","doi":"10.1016/j.prmcm.2025.100578","DOIUrl":"10.1016/j.prmcm.2025.100578","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypoxic-anoxic stress causes severe injury to the brain cells resulting in various neuropathological complications. Ginseng is widely used in Traditional Chinese Medicine (TCM) as a tonic for healthy living due to its adaptogenic/rejuvenating properties and in mitigating chronic stress-related diseases including vertigo, depression, short-term memory loss, and lack of attention or vigilance. This study evaluates the adaptogenic-like properties of <em>Panax ginseng</em> commercial product (Ginsomin) and the biochemical mechanisms underlying its action in male Swiss mice exposed to hypoxic-anoxic stress.</div></div><div><h3>Methods</h3><div>. The mice (20–22 g) were distributed into five groups (<em>n</em> = 6). Groups 1 (non-stress control) and 2 (stress-control) received distilled water while groups 3–5 had ginseng (10, 50, and 100 mg/kg), orally for seven days. Groups 2 to 5 were subjected to hypoxic stress for 20 min for six days prior to assessment of the latency to anoxic convulsion on day 7. The neurobehavioral changes (motor functions, memory, anxiety, catalepsy, depression, and muscle strength) were evaluated afterwards. Blood glucose and corticosterone levels alongside brain contents of malondialdehyde, nitrites, antioxidant profiles, pro-inflammatory cytokines (tumor necrosis factor–alpha and interleukin-6), glutamate, brain derived neurotrophic factor (BDNF), and nuclear factor kappa B (NF-κB) were determined. The brain acetylcholinesterase, caspase-3, myeloperoxidase, nuclear factor erythroid 2-related factor 2 (NFr-2) and glutamic acid decarboxylase (GAD) activities were evaluated.</div></div><div><h3>Results</h3><div>. Ginseng attenuated the anoxic convulsion and neurobehavioral deficits in stressed-mice. It reduced plasma corticosterone and glucose levels, and decreased the brain contents of malondialdehyde, nitrites, pro-inflammatory cytokines, NF-kB, caspase-3, acetylcholinesterase, glutamate and myeloperoxidase. Ginseng-treated mice had increased brain antioxidant profiles; GAD, BDNF, and NFr-2 contents relative to stress-control.</div></div><div><h3>Discussion</h3><div>. The results of the study showed that ginseng demonstrated adaptogenic-like properties by attenuating neurobehavioral deficits in mice exposed to hypoxic-anoxic stress via multiple molecular mechanisms, relating to inhibition of corticosterone-mediated oxidative and inflammatory/apoptotic signaling pathways, and activation of GAD, BDNF and NFr-2 stress-protective defense systems. Taken together, these findings further confirm its adaptogenic-like properties in alleviating common geriatric chronic stress-related diseases in Chinese medicines.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100578"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical and biological role of Apigenin: A comprehensive review","authors":"Mayukh Bhattacharya ,&nbsp;Shyamapada Mandal","doi":"10.1016/j.prmcm.2025.100576","DOIUrl":"10.1016/j.prmcm.2025.100576","url":null,"abstract":"<div><h3>Introduction</h3><div>The plant-derived bioactive compounds from the flavone structural class include APGN (apigenin), the 4, 5, and 7-trihydroxyflavone. In the traditional Chinese medicine (TCM), APGN has drawn much attention. This review-based study aims to unveil various perspectives of APGN in connection to its medical and biological roles with emphasis on anti-infective and anti-inflammatory activities, considering various APGN containing plant-based TCM formulations.</div></div><div><h3>Methods</h3><div>A thorough review of literatures was performed using various combinations of keywords, including 'Chinese medicine,' 'APGN against infection,' 'inflammation,' and TCM. A few of the other keywords that were used in this review included 'Qin Pi Tang,' 'Shu Gan Wan,' and 'Lóng Dǎn Xiè Gān Tāng. The scientific articles on the mentioned fields, published between the years 1994 and 2024 in different journals, were mined from NCBI-PubMed or Google Scholar databases to accomplish the current review.</div></div><div><h3>Results</h3><div>The literature review found that APGN possesses promising therapeutic benefits against various inflammations and bacterial, fungal, and viral infections. Combinational formulations of APGN used as TCM are one of the valuable insights that were deciphered here.</div></div><div><h3>Discussion</h3><div>The compound APGN possesses a broad spectrum of therapeutic efficacy. APGN-rich TCM-specific formulations and their applications are elaborated. They revealed anti-infective and anti-inflammatory potential. Similarly, 'Shu Gan Wan’ (SGW) and 'Lóng Dǎn Xiè Gān Tāng’ (LDZGT) including a few others, are being discussed. The role of APGN as a neuro-protectant and immune-modulatory agent is one of the valuable insights highlighted in this review. The way to address the bioavailability limitations of APGN in the form of nano-carriers has been discussed. TCM-specific terms and their brief descriptions were given in this review for better accessibility to scholarly audiences. The anti-oxidative and anticancer properties of APGN were discussed, and various clinical trials were cited in this review. Finally, this review emphasized the existing research gaps in the field. Addressing the further need for study on APGN as a bioactive compound is essential to update the medical and biological activities of APGN.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized double-blind placebo-controlled clinical trial on the efficacy and safety of herbal medicine San-jia-fu-mai (SJFM) in the treatment of atrial fibrillation and heart failure with preserved ejection fraction (yin depletion syndrome)","authors":"Yang Yang,&nbsp;Sizhao Li,&nbsp;Yujie Liu,&nbsp;Yunhu Song,&nbsp;Bing Hou,&nbsp;Shuaishuai Zhou,&nbsp;Dachang Xie","doi":"10.1016/j.prmcm.2025.100575","DOIUrl":"10.1016/j.prmcm.2025.100575","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the safety and efficacy of San-jia-fu-mai (SJFM) in patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF).</div></div><div><h3>Methods</h3><div>110 patients with HFpEF and AF were randomized in a double-blind, placebo-controlled trial to receive either SJFM or placebo for 12 weeks. Both groups received optimal medication therapy, including dapagliflozin. The primary endpoint was the improvement of KCCQ grade, Secondary endpoints included KCCQ score, E/e', NT-proBNP, and sRAGE, assessed at baseline and 4-week intervals for 12 weeks.</div></div><div><h3>Results</h3><div>After excluding 8 patients (4 in each group), 51 patients in each group (SJFM and placebo) completed the study and were included in the analysis. Both groups showed significant decreases in E/e′, NT-proBNP, and sRAGE at weeks 4, 8, and 12 compared with baseline (<em>P</em> &lt; 0.05). Both groups showed significant increases in KCCQ score at weeks 4, 8, and 12 compared with baseline (<em>P</em> &lt; 0.05). Furthermore, The SJFM group showed significantly greater decreases in NT-proBNP and sRAGE at weeks 4, 8, and 12 compared with the placebo group (<em>P</em> &lt; 0.05). Significant improvements in KCCQ and E/e′ were observed in the SJFM group at weeks 8 and 12. At week 12, the SJFM group showed a significantly greater improvement in KCCQ grade (94.12 % vs. 68.63 %; χ² = 9.14, <em>P</em> &lt; 0.05). No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>SJFM demonstrated good efficacy, safety, and tolerability in patients with AF and HFpEF, suggesting its potential as a therapeutic option. The name of the trial register is “The effect of gliflozin combined with Fumai decoction on cardiac function and prognosis in patients with heart failure and atrial fibrillation with preserved ejection fraction”. The trial was registered at <span><span>http://itmctr.ccebtcm.org.cn/</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100575"},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the scope of traditional Chinese medicinal plants in battle of antibiotic resistance – A comprehensive review","authors":"Sobhanjan Bhunia,&nbsp;Sonia Mallick,&nbsp;Asif Iqbal Mondal,&nbsp;Arkaprava Saha,&nbsp;Priyanka Ray,&nbsp;Sumana Roy,&nbsp;Tamalika Chakraborty","doi":"10.1016/j.prmcm.2025.100574","DOIUrl":"10.1016/j.prmcm.2025.100574","url":null,"abstract":"<div><h3>Introduction</h3><div>The critical issue of antimicrobial resistance within healthcare settings arises primarily from the widespread use of antibiotics. This issue underscores the global concern of bacterial resistance to multiple drugs and emphasizes the growing interest in Traditional Chinese Medicine (TCM) as a potential alternative. Notably, TCM has been reported to exhibit pathogen suppression and bactericidal capabilities while demonstrating minimal therapeutic resistance.</div></div><div><h3>Methodology</h3><div>A comprehensive literature search was conducted across multiple databases, including Google Scholar, Scopus, PubMed, and Web of Science. Over 250 articles published since 2010 were initially identified, from which 230 were shortlisted based on their relevance to keywords such as “Traditional Chinese Medicine,” “Bioactive Compounds,” “Conventional Antibiotics,” “Antibiotic-Resistant Bacteria,” “Resistance Mechanisms,” and “synergistic effects” The selected 205 articles were thoroughly analyzed to compile the most recent and significant developments included in this review. All chemical structures and mechanisms were prepared using ChemDraw software, following guidelines and structural data from the PubChem database.</div></div><div><h3>Results</h3><div>TCM contains active components like flavonoids, alkaloids, phenols, and polysaccharide quinones that can impede the growth of antibiotic-resistant pathogens. Studies have examined the increasing threat and global impact of antibiotic-resistant pathogens, causes, and mechanisms of antibiotic resistance. Researches have investigated the suppressive properties of TCM plants and their bioactive substances on pathogens. Combinatorial effect of TCM plants with conventional antibiotics has garnered attention for its potential to enhance the therapeutic effectiveness against drug-resistant bacterial strains. Preclinical results demonstrate the efficacy of TCM herbs and their phytochemical compounds against antibiotic-resistant bacteria in mice. The review identified ongoing challenges in the development of TCM.</div></div><div><h3>Discussion</h3><div>This review concludes by discussing the implications of the findings. It suggests that TCM plants and their bioactive phytoconstituents show promising results in addressing conventional antibiotic resistance in bacterial pathogens. The discussion also highlights the potential for developing innovative treatment approaches to overcome resistance using TCM. This indicates a positive outlook for using TCM in combating antimicrobial resistance while acknowledging the need for further research and development in this area.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective role of traditional Chinese plant extracts on Parkinson's disease; a comprehensive preclinical review","authors":"Rabia Anjum","doi":"10.1016/j.prmcm.2025.100573","DOIUrl":"10.1016/j.prmcm.2025.100573","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Parkinson's disease (PD) is a complex neurodegenerative disorder primarily characterized by gradual loss of dopaminergic neurons in the substantia nigra of the midbrain. Despite extensive research, a definitive cure that alters the progression of PD remains elusive. Herbal remedies, particularly those employed in Traditional Chinese Medicine (TCM), have been used for centuries in Asia to manage neurological conditions. Recently, there has been a renewed interest in these treatments, motivated by their potential to inform the development of pharmaceuticals that not only address PD symptoms but also modify the underlying disease mechanisms. Highlighting the urgency of this research, the increasing global prevalence of PD, expected to affect approximately 12 million individuals by 2040, underscores the urgent need for novel therapeutic strategies. Additionally, the limitations of current treatments, which often have come with significant side effects, create a compelling case for exploring the neuroprotective properties of TCM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This review outlines the pathogenic mechanisms underlying PD including protein aggregation, mitochondrial dysfunction, ion imbalance, neuroinflammation, and oxidative stress. An extensive literature search was conducted using the PubMed and Web of Science, focusing on studies that examined Chinese herbal remedies and their key bioactive compounds in the context of PD. Articles were selected based on relevance, research rigor, and the availability of data from both in vitro and in vivo PD models. Keywords used, included “Parkinson's disease,” “Traditional Chinese Medicine,” “bioactive compounds,” “oxidative stress,” and “neuroinflammation.”&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;This review identified several TCM herbal preparations and their primary bioactive components that have shown promising effects in PD models. These compounds, including Ginsenosides, Epigallocatechin gallate, Curcumin, Sesamin, Eleutheroside B, Saponin, Theacrine, Ginkgetin, and Gypenosides, were analyzed for their mechanisms of action. The neuroprotective effects of these compounds are linked to the pathways associated with oxidative stress, inflammation, and cellular protection. Extraction methods, primarily ethanol- or water-based methods, play a significant role in isolating these active ingredients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;The findings indicate that TCM herbs and their bioactive constituents may offer valuable insights for developing PD-modifying therapies. The studied compounds demonstrated effects on essential signaling pathways related to oxidative and inflammatory stress in neurons. Understanding these mechanisms may guide the development of novel therapeutics aimed at slowing or altering PD progression. This review highlights the potential of integrating traditional herbal knowledge with modern scientific research to meet the unmet needs of patients with PD.&lt;/di","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100573"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}