Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Pharmacological effects of Berberine – A Chinese medicine, against xenobiotics toxicity","authors":"Annu Phogat,&nbsp;Jagjeet Singh,&nbsp;Vinay Malik","doi":"10.1016/j.prmcm.2024.100507","DOIUrl":"10.1016/j.prmcm.2024.100507","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine has used plant-derived natural antioxidants from herbs since ages. Berberine is an iso-quinoline-based alkaloid found in various medicinal herbs: <em>Coptis chinensis (Huanglian), Phellodendron amurense (Huangbai</em>) and used in traditional Chinese medicine as decoctions: ‘<em>Xie Xin</em>’ and ‘<em>Huanglian Jiedu</em>’. It has been used since long to treat inflammation, auto-immune diseases and dysentery. Studies have also confirmed its antioxidative, anti-inflammatory, anti-apoptotic, and pharmacological properties. Still, there is a gap between the preclinical significance and clinical efficacy of Berberine against organ toxicity. Thus, the present review summarises the ameliorative potential of Berberine against free radicals-mediated oxidative stress, cholinergic stress, inflammation, mitochondrial dysfunctions, and apoptosis.</div></div><div><h3>Methods</h3><div>Various scientific research articles in Google Scholar, PubMed, Scopus, Web of Science, and ScienceDirect, were explored to find the pharmacological effects of Berberine. More than 80 articles since 2010 were explored among which 40 were shortlisted with the keywords: Berberine followed by ‘mechanism,’ ‘ameliorative properties,’ ‘pharmacological properties,’ ‘antioxidant; Berberine against ‘pesticide toxicity’, ‘heavy metal toxicity’ ‘nephrotoxicity’ ‘hepatotoxicity’ ‘neurotoxicity’. The thus selected research articles were carefully read to summarise the latest and most recent developments in writing of this review.</div></div><div><h3>Results</h3><div>The structural and functional diversity of Berberine is responsible for the protective efficacy against organ toxicity. The molecular mechanism of Berberine suggests attenuation of oxidative stress, regulation of endogenous antioxidants, and activation of signaling pathways, including PPARɣ/PGC-1α, HNF4α/MTTP, PTEN/Akt, Nrf-2/HO-1/MnSOD, and SIRT1/P66Shc along with inhibition of NF-κB translocation; can ameliorate organ dysfunctioning.</div></div><div><h3>Discussion</h3><div>The current review summarises a baseline and preclinical evidence comprising their mechanistic bases, highlighting the ethnopharmacological applications of Berberine for both traditional Chinese medicine and modern therapeutics. This evaluation will give the crucial insight essential for toxicological and pharmacokinetic research on human models to verify the safety issues and confirm the effects of active components of Berberine in the body in a clinical context.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100507"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001490/pdfft?md5=cceb8eedb132a15c4a47e76fb0bba748&pid=1-s2.0-S2667142524001490-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma Oryzanol: A natural compound with potential for treating polycystic ovary syndrome","authors":"Sayantika Chakraborty,&nbsp;Navneet Khurana,&nbsp;Jaskiran Kaur,&nbsp;Meenu Mehta,&nbsp;Neha Sharma","doi":"10.1016/j.prmcm.2024.100506","DOIUrl":"10.1016/j.prmcm.2024.100506","url":null,"abstract":"<div><h3>Introduction</h3><p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Current management strategies only provide symptomatic relief, and there is a need for better treatments. Gamma-oryzanol, a dietary component found in rice bran oil, has been shown to be effective in increasing insulin sensitivity, reducing weight, and alleviating oxidative stress. In modern Chinese medicine, 香格里拉谷维素胶囊, 纯净谷维素软胶囊, and 诺特博谷维素片 are some of the medicines marketed in China that contain gamma-oryzanol. This study aims to evaluate the effects of gamma-oryzanol on clinical hallmarks of PCOS. Also to compare the efficacy of gamma-oryzanol alone versus in combination with clomifene citrate.</p></div><div><h3>Methods</h3><p>In this study, PCOS was induced in a rat model using estradiol valerate. Gamma-oryzanol was then administered both alone and in combination with clomifene citrate.</p></div><div><h3>Results</h3><p>The effects of gamma-oryzanol on estrous cyclicity, fertility, histopathological alterations, estradiol and testosterone levels, and oxidative parameters were evaluated. The results showed that gamma-oryzanol, both alone and in combination with clomifene citrate, had protective effects against the estradiol valerate-induced PCOS rat model. The combination of gamma-oryzanol and clomifene citrate was particularly effective, showing significantly better results than the standard treatment group (clomifene citrate alone).</p></div><div><h3>Discussion</h3><p>These results suggest that gamma-oryzanol could be used in combination with existing standard treatments to enhance the management of PCOS. However, further molecular and clinical studies are needed to confirm these findings.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100506"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001489/pdfft?md5=5f6bcca05a354f4ecd74b244470761fd&pid=1-s2.0-S2667142524001489-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on anticancer potential of traditional Chinese medicine (Yang Zheng XiaoJi)","authors":"Krishn Kumar Agrawal ,&nbsp;Yogesh Murti","doi":"10.1016/j.prmcm.2024.100505","DOIUrl":"10.1016/j.prmcm.2024.100505","url":null,"abstract":"<div><h3>Background</h3><p>The term \"cancer\" refers to illnesses in which cells can proliferate uncontrollably, infiltrate, and spread to various body organs. Since it has been used for thousands of years, traditional Chinese medicine (TCM) is now commonly regarded as an alternative for treating cancer. It has been demonstrated that Yangzheng Xiaoji (YX), a traditional Chinese medicine formulation, has anticancer effects in patients with different tumor types.</p></div><div><h3>Method</h3><p>Searches were conducted in several electronic databases from the year 2003 to 2024, including Pubmed, Google Scholar, Scopus, and Science Direct, to find evidence about YX. The purpose of this review is to provide an overview of YX's anticancer research findings.</p></div><div><h3>Result</h3><p>A result of the limited understanding of the fundamental mechanisms of action of the herbs, modern medicine frequently conflicts with traditional medicine, such as Chinese herbal medicine. Our research demonstrates the broad spectrum of anticancer potential of the YX formulation. Additionally, the particular YX component was also searched for anticancer potential.</p></div><div><h3>Discussion</h3><p>We have chosen to emphasize only some aspects of each YX ingredient's function in cancer therapy because it has been suggested that several processes are involved when applying TCM therapies. Furthermore, the effect of YX therapy on various malignancies is also covered. Additionally, we have emphasized YX treatment research that alters the tumor microenvironment and eradicates cancer.</p></div><div><h3>Conclusion</h3><p>The data gathered in this review will act as a strong basis for creating YX for cancer therapy.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100505"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001477/pdfft?md5=18c624b34e4564bc87ee66ee00391502&pid=1-s2.0-S2667142524001477-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hehuan Anshen decoction inhibits ferroptosis to ameliorate p-Chlorophenylalanine-induced insomnia by activating GPX4 pathway","authors":"Qing Deng ,&nbsp;Yanan Li ,&nbsp;Wenyun Kui ,&nbsp;Linting He ,&nbsp;Yuxia Wang ,&nbsp;Nana Li ,&nbsp;Jian Xu ,&nbsp;Kaiqiang Wang ,&nbsp;Chunchun Xue ,&nbsp;Zhongwei Sha","doi":"10.1016/j.prmcm.2024.100504","DOIUrl":"10.1016/j.prmcm.2024.100504","url":null,"abstract":"<div><h3>Introduction</h3><p>Insomnia is a chronic disease affecting a third of the global adult population. Hehuan Anshen Decoction (HHASD), an innovative formula derived from Traditional Chinese medicine, has demonstrated therapeutic efficacy in treating insomnia, however, the potential pharmacological mechanism underlying its anti-insomnia effects remains incompletely elucidated. This study aimed to explore the underlying mechanism of HHASD treatment in mice with insomnia induced by p-Chlorophenylalanine (PCPA).</p></div><div><h3>Methods</h3><p>The active constituents of HHASD were analysed by means of UPLC<img>HRMS. PCPA mice were administered HHASD orally for 7 days. The anti-insomnia phenotype of HHASD were assessed by behavioral tests, encompassing the open field test and pentobarbital sodium-induced sleep test, alongside the measurement of hypothalamic 5-HT levels. Then, we conducted an in-depth analysis of specific ferroptosis markers, considering biochemistry, genetics and morphology. Additionally, ferroptosis inhibitor RSL3 was used to observe the underlying mechanism of the effects of HHASD.</p></div><div><h3>Results</h3><p>HHASD could effectively improve the insomnia behaviors induced by PCPA, resulting in increased movement trajectories, decreased sleep latency and prolonged sleep duration. Specifically, HHASD exerted a neuroprotective effect by enhancing the integrity of Nissl bodies in the hypothalamus of the PCPA mice. Mechanistic analysis revealed that HHASD could reverse the hypothalamic ferroptosis phenotype of insomnia mice by restoring the lowered levels of glutathione (GSH), inhibiting iron accumulation and elevated malondialdehyde (MDA), and mitigating mitochondrial cristae damage. Furthermore, HHASD enhanced the expression of SLC7A11 and GPX4 and reduced the ASCL4 in the hypothalamus, while the anti-insomnia effect of HHASD in the PCPA mice was eliminated by the GPX4 inhibitor RLS3.</p></div><div><h3>Conclusion</h3><p>HHASD ameliorates insomnia-related behaviors and protects against neuronal damage by suppressing ferroptosis by regulation GPX4 signaling. This study is not only a valuable attempt to explore the potential mechanism of Traditional Chinese formula but also will provide a novel targeted therapy for the treatment strategy of insomnia.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100504"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001465/pdfft?md5=fc851356a17336fcd2a9eaf3831f7f37&pid=1-s2.0-S2667142524001465-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the healing powers of Saikosaponin A: A review of current perspectives","authors":"Ahsas Goyal,&nbsp;Anshika Kumari,&nbsp;Kunal Solanki,&nbsp;Aanchal Verma,&nbsp;Nandini Agrawal","doi":"10.1016/j.prmcm.2024.100500","DOIUrl":"10.1016/j.prmcm.2024.100500","url":null,"abstract":"<div><h3>Introduction</h3><p>Saikosaponin A (SSA), a triterpenoid saponin derived from <em>Radix Bupleuri</em>, is a prominent bioactive compound known for its therapeutic potential. Importantly, SSA is recognized for its widespread use in contemporary Chinese medicinal formulations. The current review highlights SSA's promising role in developing pharmaceuticals and dietary supplements for diverse medical applications, supported by extensive empirical evidence (2001–2024).</p></div><div><h3>Methodology</h3><p>Literature search across Google Scholar, Scopus, PubMed, and Web of Science, covering publications from 2001 to 2024, aimed to gather extensive information on the pharmacological properties of Saikosaponin A. Using keywords such as “Saikosaponin A,” “Oxidative stress,” “Cancer,” “Inflammation,” “Neuroprotection,” and “Apoptosis,” this review consolidates existing knowledge and offers potential avenues for future research.</p></div><div><h3>Results</h3><p>This study incorporates findings from various <em>in vitro</em> and <em>in vivo</em> investigations to evaluate SSA's efficacy across multiple health conditions, including cancer, inflammatory diseases, viral infections, cardiac ailments, and neurological disorders. The results demonstrate that SSA exhibits significant therapeutic effects in treating various cancers, mitigating inflammation, providing neuroprotection in conditions such as Parkinson's disease, epilepsy, and depression, combating influenza A virus, and aiding in obesity management.</p></div><div><h3>Discussion</h3><p>Conclusively, this review highlights the therapeutic potential of SSA, underscoring its importance in treating chronic diseases related to the central nervous system, neoplasms, and inflammatory pathways. Continued research into SSA could yield significant advancements in managing these conditions, reinforcing its value in both traditional and modern medical practices.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100500"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001428/pdfft?md5=de3ce52b0e945368f63f8c8c2b2bce63&pid=1-s2.0-S2667142524001428-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scopoletin and rutin attenuate ethanol reward in mouse-conditioned place preference test","authors":"Vijayapandi Pandy ,&nbsp;Kamini Vijeepallam ,&nbsp;Nurul Fatin Amira Roslan ,&nbsp;Arif Sajat ,&nbsp;Yew Chang Wai ,&nbsp;Phani Sai Vennela Ramisetty ,&nbsp;Vulli Naga Jyothi","doi":"10.1016/j.prmcm.2024.100501","DOIUrl":"10.1016/j.prmcm.2024.100501","url":null,"abstract":"<div><h3>Introduction</h3><p>In Traditional Chinese Medicine (TCM), <em>Morinda citrifolia</em> Linn. (Hai ba ji), is utilized for its various parts such as leaves, fruits, flowers, roots, and bark, serving as a tonic and addressing ailments including fever, skin, eye, throat, and gum issues, as well as nausea, vomiting, and neurological diseases. Previous research indicated that <em>M. citrifolia</em> Linn. fruit and its juice reduced ethanol-conditioned place preference (CPP) in mice, with scopoletin (SCOP) and rutin (RUT) proposed as the main bioactive compounds responsible for this effect. This study aimed to evaluate the impact of SCOP and RUT on ethanol reward using the CPP test in mice.</p></div><div><h3>Methods</h3><p>The CPP protocol consisted of a habituation phase spanning 3 days, a 1-day preconditioning phase, 10 days of conditioning, a rest day, and a post-conditioning day. The vehicle-saline control and vehicle-ethanol control groups received oral administration of a 1 % w/v solution of sodium carboxymethyl cellulose (CMC) at a dosage of 10 ml/kg. SCOP and RUT were administered orally at doses ranging from 0.05 to 1 mg/kg body weight (bw), while acamprosate (ACAM) was administered at a dosage of 300 mg/kg bw, all one hour before postconditioning. Statistical analyses utilized both repeated measures two-way and one-way ANOVA.</p></div><div><h3>Results</h3><p>Oral administration of SCOP (0.05, 0.1, and 0.5 mg/kg bw) and RUT (0.05 mg/kg bw) one hour before postconditioning testing on day 16 markedly reduced ethanol CPP in mice. Additionally, SCOP and RUT at all tested doses (0.05–1 mg/kg bw, p.o.) did not induce any changes in normal locomotor activity in mice.</p></div><div><h3>Discussion</h3><p>These results suggest that SCOP and RUT diminish ethanol reward in mice, underscoring the therapeutic potential of these phytochemicals in managing alcohol use disorder.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100501"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266714252400143X/pdfft?md5=fad342c6c402eab91e998fb582ea03b0&pid=1-s2.0-S266714252400143X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call to action: Addressing the knowledge gap in traditional Chinese medicine's role against acral lentiginous melanoma","authors":"Amin Sharifan ,&nbsp;Sarena Saee ,&nbsp;Soheila Saee","doi":"10.1016/j.prmcm.2024.100503","DOIUrl":"10.1016/j.prmcm.2024.100503","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100503"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001453/pdfft?md5=e43d6f2bb76b6f98a547391f73a7e399&pid=1-s2.0-S2667142524001453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into the bactericidal and phytochemical properties of leaf extract of Vernonia squarrosa and understanding antibacterial activity by molecular docking","authors":"Adwaita Das ,&nbsp;Sunanda Burman ,&nbsp;Chandan Das ,&nbsp;Moitri Bhadra ,&nbsp;Sumita Mondal ,&nbsp;Pratiti Rakshit ,&nbsp;Goutam Chandra ,&nbsp;Abhijit Bandhyopadhyay","doi":"10.1016/j.prmcm.2024.100502","DOIUrl":"10.1016/j.prmcm.2024.100502","url":null,"abstract":"<div><h3>Introduction</h3><p>Numerous plants in the <em>Vernonia</em> genus are used in Traditional Chinese Medicine (TCM) to treat a wide range of illnesses, such as pityriasis rubra pilaris, infections, wounds, dermatitis, mastitis, diarrhoea, and colds. These genera also have antibacterial, antipyretic, and anti-inflammatory properties. The current work sought to investigate the bactericidal and phytochemical characteristics of <em>Vernonia squarrosa</em> leaf extract and comprehend antibacterial action using molecular docking.</p></div><div><h3>Methods</h3><p>An in vitro study was carried out to investigate the antibacterial capabilities of <em>V. squarrosa</em>. HRLCMS analysis was conducted to determine the phytoconstituents of the chloroform extract (LC). For molecular docking validation, PyRx, an Open Babel integrated Auto Dock programme, was used.</p></div><div><h3>Results</h3><p>Present investigation reveals strong antibacterial activity against two tested gram-positive and gram-negative bacterial strains compared to other solvent extracts, LC at a higher concentration demonstrated a better response. Against <em>Bacillus subtilis</em> (20.05±0.88 mm) and <em>Escherichia coli</em> (20 ± 0.00 mm), the active components of the extracts formed the largest inhibitory zone followed by Pseudomonas aeruginosa (19.50±0.50 mm) and Staphylococcus aureus (14.33 ± 0.33 mm)<em>.</em> The LC extract had lower minimum inhibitory concentrations (MIC) and stronger bactericidal activity than the other extracts.</p></div><div><h3>Discussion</h3><p><em>V. squarrosa</em>'s LC showed higher levels of antibacterial activity against the tested bacterial strains than other solvent extracts, most likely as a result of the presence of 31 chemical components, including flavonoids, glycosides, alkaloids, phenolics, and triterpenoids. Developing unique TCM formulations assume significance in global healthcare scenarios to combat bacterial infections and in this context, the current paper underlines the importance of the potent antimicrobial properties of chloroform extract of <em>V. squarrosa.</em> This study revealed that chloroform extract of <em>V. squarrosa</em> has a great deal of antibacterial activity.</p></div><div><h3>Conclusion</h3><p>According to the study, <em>V. squarrosa</em> leaf chloroform extract possesses antibacterial properties because of its active phytocompounds. Its wide range of bioactive components makes it a prime choice for developing novel formulations to neutralize threats of newly emerging strains of harmful bacteria. The aforementioned discoveries may deepen our comprehension of phenomenal wisdom and deep science associated with the legendary TCM.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100502"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001441/pdfft?md5=6be0c05ab21b0703a2cfa5071b1c560a&pid=1-s2.0-S2667142524001441-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review and recent advancement in the application of tannins for treating Parkinson disease","authors":"Trilochan Satapathy,&nbsp;Deepak Kumar","doi":"10.1016/j.prmcm.2024.100499","DOIUrl":"10.1016/j.prmcm.2024.100499","url":null,"abstract":"<div><h3>Introduction</h3><p>Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. Despite extensive research, the etiology of PD remains elusive, and current treatments focus primarily on symptomatic relief rather than disease modification.</p></div><div><h3>Methods</h3><p>The papers were searched in Web of Science, Scopus, PubMed, PubMed Prime, Cochrane library, Sciencedirect and Google Scholar as web resources. This article includes information about tannins research and reviews in the treatment of PD. However, other paper related to CNS have been avoided.</p></div><div><h3>Results</h3><p>In recent years, there has been growing interest in exploring the therapeutic potential of natural compounds, such as tannins, for the management of PD. Tannins, polyphenolic compounds found abundantly in various plant species, have demonstrated neuroprotective effects through their antioxidant, anti-inflammatory, and metal chelating properties. This review provides a comprehensive overview of the current understanding of PD pathophysiology, existing treatment modalities, and the potential role of tannins in PD management. Additionally, recent advancements in the application of tannins, including in vitro and in vivo studies, clinical trials, and novel delivery systems, are discussed. Furthermore, challenges and future perspectives regarding the translation of tannin-based therapies into clinical practice are addressed.</p></div><div><h3>Discussion</h3><p>Overall, this review highlights the promising therapeutic potential of tannins in the treatment of Parkinson's disease and underscores the need for further research to elucidate their mechanisms of action and optimize their clinical efficacy.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100499"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001416/pdfft?md5=4e67bd21032c8afb246036f78193c18e&pid=1-s2.0-S2667142524001416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergisitic anti-colorectal cancer effects of WNT974 combined with artesunate via cooperative regulation of p21, p27, and AKT","authors":"Rui-Hong Gong ,&nbsp;Minting Chen ,&nbsp;Chunhua Huang ,&nbsp;Hoi Leong Xavier Wong ,&nbsp;Sibao Chen ,&nbsp;Zhaoxiang Bian ,&nbsp;Guo-Qing Chen","doi":"10.1016/j.prmcm.2024.100498","DOIUrl":"10.1016/j.prmcm.2024.100498","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the synergistic effects and underlying mechanisms of WNT974 and artesunate (ART) combination therapy in the treatment of colorectal cancer (CRC).</p></div><div><h3>Methods</h3><p>We conducted an initial assessment of the synergistic impact of WNT974 and ART on cell viability using the MTT assay across eight CRC cell lines with diverse mutation statuses.Subsequently, a 3D <em>in vitro</em> model was utilized to confirm the synergistic effect of the combination. Flow cytometry was employed to analyze cell cycle distribution. The molecular mechanisms were further investigated by examining the expression levels of cell cycle-related proteins (p21, p27, and CDK2) and AKT activity through PCR and Western blot analyses. The <em>in vivo</em> efficacy of the combination therapy was evaluated using a xenograft mouse model of CRC.</p></div><div><h3>Results</h3><p>The combination of WNT974 and ART significantly reduced cell viability in all eight CRC cell lines, demonstrating a synergistic effect. Additionally, the combination exhibited synergy in inhibiting 3D spheroid growth. Cell cycle analysis revealed that the combination therapy induced a marked G1/G0 arrest through CDK2 inhibition, surpassing the efficacy of individual treatments. Molecular analysis indicated that the combination therapy upregulated p21 and p27 expression and reduced AKT activity. <em>In vivo</em>, the combination therapy significantly inhibited tumor growth in the xenograft mouse model, notably outperforming 5FU, the standard first-line drug for CRC.</p></div><div><h3>Conclusion</h3><p>The study highlights the synergistic anti-CRC effects of combining WNT974 and ART. This combination induces G1/G0 phase cell cycle arrest by cooperatively regulating p21, p27, and AKT, presenting a promising alternative to current CRC treatments. These findings elucidate the molecular basis of this interaction and provide a scientific foundation for advancing ART combined with WNT94 as a novel therapy for CRC, offering a potential new avenue.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100498"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001404/pdfft?md5=fb3aa952ebfe87e75eb9c0a41cb9c137&pid=1-s2.0-S2667142524001404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}