Pharmacological Research - Modern Chinese Medicine最新文献

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Exploration of the anti-membranous glomerulonephritis mechanism of Acanthopanacis Cortex using network pharmacology and experimental verification 棘五加皮质抗膜性肾小球肾炎机制的网络药理学探讨及实验验证
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-06-01 DOI: 10.1016/j.prmcm.2025.100632
Shan Liu , Ziye Dong , Hongyan Gu , Yamin Xiong , Wei Su , Fei Cao
{"title":"Exploration of the anti-membranous glomerulonephritis mechanism of Acanthopanacis Cortex using network pharmacology and experimental verification","authors":"Shan Liu ,&nbsp;Ziye Dong ,&nbsp;Hongyan Gu ,&nbsp;Yamin Xiong ,&nbsp;Wei Su ,&nbsp;Fei Cao","doi":"10.1016/j.prmcm.2025.100632","DOIUrl":"10.1016/j.prmcm.2025.100632","url":null,"abstract":"<div><h3>Introduction</h3><div>Membranous glomerulonephritis (MGN), an autoimmune kidney disease, often progresses to renal failure. Current treatments have significant side effects, highlighting the need for alternatives. <em>Acanthopanacis</em> Cortex (AC, <em>Wujiapi</em>), a Traditional Chinese Medicine, exhibits anti-inflammatory and antioxidant properties, but its mechanisms in MGN are unclear. Using network pharmacology and cell experiments, this study investigates AC’s therapeutic potential in MGN.</div></div><div><h3>Methods</h3><div>AC constituents were sourced from literature and TCMSP, with targets predicted using PharmMapper and SwissTargetPrediction (OB ≥ 30 %, DL ≥ 0.18) and standardized via UniProt. MGN-related targets from DisGeNET and CTD were analyzed using Venn diagrams, Cytoscape networks, and STRING PPI, with enrichment via Metascape. Core compounds and targets were validated by molecular docking with AutoDock and PDB. RAW264.7 cells treated with AC, sesamin, and LPS were assessed for viability (MTT), NO production (Griess), COX-2/iNOS (Western blot), and ROS (DCFH-DA staining).</div></div><div><h3>Results</h3><div>15 bioactive compounds from AC, targeting 409 genes (109 linked to MGN), were analyzed, revealing key pathways via PPI, KEGG, and GO. Molecular docking confirmed strong compound-protein interactions. AC and sesamin (≤50 μg/mL/μM) reduced NO, inhibited COX-2/iNOS, and alleviated oxidative stress in LPS-induced inflammation without toxicity.</div></div><div><h3>Discussions</h3><div>TCM extracts like <em>Tripterygium wilfordii, Astragalus membranaceus</em>, and <em>Panax notoginseng</em> exhibit anti-inflammatory and kidney-protective effects, particularly in minimal change nephrotic syndrome (MGN). AC, derived from <em>P. notoginseng</em>, shows therapeutic promise in MGN models. Using network pharmacology, this study identified five key components in AC, including (-)-kaur-16-en-19-oic acid, acanthoic acid, sesamin, and β-sitosterol, which modulate pathways like PI3K-Akt, JAK-STAT, and MAPK, suggesting mechanisms for MGN treatment. Experimental validation confirmed AC’s anti-inflammatory effects in LPS-stimulated cells, reducing NO release, oxidative stress, and cytokines, supporting its efficacy in MGN.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100632"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemistry, pharmacological potential, and network-based insights of Eucommia ulmoides in traditional Chinese medicine 杜仲在中药中的植物化学、药理潜力和基于网络的见解
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-06-01 DOI: 10.1016/j.prmcm.2025.100633
Suruchi, Mahima Tiwari, Ajay Kumar Gupta, Dipti Pal, Sanmati Kumar Jain
{"title":"Phytochemistry, pharmacological potential, and network-based insights of Eucommia ulmoides in traditional Chinese medicine","authors":"Suruchi,&nbsp;Mahima Tiwari,&nbsp;Ajay Kumar Gupta,&nbsp;Dipti Pal,&nbsp;Sanmati Kumar Jain","doi":"10.1016/j.prmcm.2025.100633","DOIUrl":"10.1016/j.prmcm.2025.100633","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Eucommia ulmoides</em> (EU) has been widely used in Traditional Chinese Medicine (TCM) for centuries, particularly for strengthening the liver and kidneys, supporting bone health, and managing hypertension. Although it has a lengthy application history, incorporating this substance into contemporary medical practices has been somewhat restricted. It comprises more than 200 identified compound including flavonoids, iridoids, lignans, phenolic acid, steroid<strong><em>,</em></strong> terpenoids, and carbohydrates etc. This review intends to consolidate the current knowledge of their pharmacological effects of <em>EU</em> and explore its prospective therapeutic advantages utilizing the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Many effective active components from TCMSP database were identified by researchers, based on profiles of drug-likeness (DL ≥ 0.18) and oral bioavailability (OB ≥ 30 %).</div></div><div><h3>Methods</h3><div>An extensive literature survey was done using multiple databases such as Google Scholar, PubMed, Springer Link, and Science Direct, to examine the phytoconstituents and pharmacological effects of EU. This article seeks to provide a summary of its primary chemical constituents and pharmacological activities associated with EU.</div></div><div><h3>Results</h3><div>EU, recognized as a traditional herbal remedy, has been employed for its various therapeutic potentials, including antihypertensive effects, anti-inflammatory, neuroprotective, hypoglycaemic effects, and hypolipidemic properties. Additionally, digestive benefits, hepatoprotective effects, antitumor activities, antioxidant activities, antimicrobial effects, immunomodulatory activities, and anti-osteoporosis effects were also reported by different researchers. Furthermore, it acts on the CNS, reducing inflammation, helping with Alzheimer's disease, and hypnotic and anticonvulsant traits. It also provides renal protective effects, anti-aging benefits, and anti-hyperuricemia properties.</div></div><div><h3>Discussion</h3><div>Experimental research supports certain pharmacological properties of EU, a traditional herbal medicine. However, further studies are necessary to fully understand its implications and therapeutic potential.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100633"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective role of terminalia chebula and coconut oil in acute lung injury: Bioactive compound analysis and histopathological evidence 枳实和椰子油对急性肺损伤的保护作用:生物活性化合物分析和组织病理学证据
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-30 DOI: 10.1016/j.prmcm.2025.100634
Kamalakannan Solaiyappan , Sowjanya Bandlamudi , Lavanya Prathap , Vaijayanthimala Ponnusamy , Shyamaladevi Babu
{"title":"Protective role of terminalia chebula and coconut oil in acute lung injury: Bioactive compound analysis and histopathological evidence","authors":"Kamalakannan Solaiyappan ,&nbsp;Sowjanya Bandlamudi ,&nbsp;Lavanya Prathap ,&nbsp;Vaijayanthimala Ponnusamy ,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.prmcm.2025.100634","DOIUrl":"10.1016/j.prmcm.2025.100634","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are critical conditions involving severe lung inflammation and impaired gas exchange. They are often triggered by sepsis, pneumonia, or trauma. Current therapies mainly provide supportive care without addressing the root inflammatory causes. Natural compounds with anti-inflammatory properties are being explored as adjunct treatments. <em>Terminalia chebula</em> (Haritaki), a key medicinal plant in traditional Ayurvedic and Chinese medicine and virgin coconut oil are rich in bioactive known for their therapeutic and anti-inflammatory benefits.</div></div><div><h3>Materials &amp; Methods</h3><div>This study aimed to identify the bioactive compounds present in Haritaki using Gas Chromatography-Mass Spectrometry (GC–MS) analysis on an ethanol extract. The GC–MS analysis revealed 30 bioactive compounds, which were identified based on their retention times and peak areas. These compounds displayed promising pharmacological properties, suggesting their potential use in the development of novel drugs or as crude drugs.</div></div><div><h3>Results</h3><div>The study also investigated the therapeutic potential of <em>T. chebula</em> and coconut oil in a mouse model of ALI, a serious condition characterized by inflammation and impaired gas exchange, which often progresses to ARDS and is associated with high mortality rates. The histopathological analysis of lung tissues from mice indicated that the group pre-treated with <em>T. chebula</em> and coconut oil exhibited significant therapeutic benefits. This included a reduction in lung inflammation, improved tissue repair, and overall better histopathological outcomes.</div></div><div><h3>Conclusion</h3><div>These findings suggest that <em>T. chebula</em> and coconut oil, either independently or in combination, may have potential as therapeutic agents for conditions like ALI and ARDS, contributing to enhanced lung health and recovery.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100634"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the therapeutic potential of quercetin, a widely spread flavonoid, in the prevention and management of chronic and degenerative diseases through a modern Chinese medicine perspective 槲皮素是一种广泛应用的类黄酮,从现代中医角度评价槲皮素在预防和治疗慢性和退行性疾病中的治疗潜力
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-29 DOI: 10.1016/j.prmcm.2025.100630
Issac V Cherian , Abhishek Vijukumar , Md Mustahidul Islam , Janvi , Akash Vikal
{"title":"Assessing the therapeutic potential of quercetin, a widely spread flavonoid, in the prevention and management of chronic and degenerative diseases through a modern Chinese medicine perspective","authors":"Issac V Cherian ,&nbsp;Abhishek Vijukumar ,&nbsp;Md Mustahidul Islam ,&nbsp;Janvi ,&nbsp;Akash Vikal","doi":"10.1016/j.prmcm.2025.100630","DOIUrl":"10.1016/j.prmcm.2025.100630","url":null,"abstract":"<div><h3>Introduction</h3><div>It is evident in Traditional Chinese Medicine that quercetin (QUE, 槲皮素, Húpísù) is present in many fruits, vegetables, and herbs, including Sophora japonica (槐花, Huáihuā) and Ginkgo biloba (银杏, Yínxìng). It is recognized for its protective antioxidant, anti-inflammatory, antidiabetic, antimicrobial, and immunomodulatory effects.</div></div><div><h3>Methods</h3><div>We looked for studies in PubMed, ScienceDirect, and Google Scholar from 2000 to 2025. The keywords we chose were “quercetin,” “chronic diseases,” “antioxidant,” “anti-inflammatory,” and “Traditional Chinese Medicine.” Findings on QUE’s drug interactions, problems figuring out its dosing, and its place in TCM were examined.</div></div><div><h3>Results</h3><div>QUE prevents some of the negative effects of ageing and chronic diseases by acting as an effective antioxidant. It controls inflammation by cutting back on TNF-α, IL-6, IL-1β, and by blocking NF-κB, MAPK, and PI3K/Akt pathways. QUE improves how the body uses insulin, supports the function of β-cells, and regulates sugar metabolism using AMPK and GLUT4. Tea tree oil acts against germs by rupturing membranes and prohibiting biofilm from forming. Ques presents itself as an enhancer of Treg cell differentiation and a way to decrease uncontrolled actions of the immune system in autoimmune disorders. Yet, its clinical application is not strong because it breaks down easily and has low bioavailability.</div></div><div><h3>Discussion</h3><div>Because QUE has a wide range of therapeutic effects, it is being used more often in treatments for ongoing and inflammatory health problems. Traditional Russian Medicine makes it clear that ancient ideas can be used with modern medical approaches. In the future, scientists should examine how to improve the delivery of QUE and validate its use in clinical trials.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100630"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical observation of the treatment of acute pancreatitis with traditional Chinese medicine compound preparation 中药复方制剂治疗急性胰腺炎的临床观察
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-25 DOI: 10.1016/j.prmcm.2025.100628
Xiao Teng , Shanfeng Sheng , Mingyuan Pan , Yuyang Li , Zheng Li
{"title":"Clinical observation of the treatment of acute pancreatitis with traditional Chinese medicine compound preparation","authors":"Xiao Teng ,&nbsp;Shanfeng Sheng ,&nbsp;Mingyuan Pan ,&nbsp;Yuyang Li ,&nbsp;Zheng Li","doi":"10.1016/j.prmcm.2025.100628","DOIUrl":"10.1016/j.prmcm.2025.100628","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute pancreatitis (AP), a prevalent gastrointestinal disorder characterized by pancreatic auto-digestion, currently lacks targeted therapeutic agents despite its clinical significance. In contemporary medical practice, traditional Chinese medicine (TCM) formulations have gained increasing clinical traction for AP management in China. This retrospective controlled trial systematically investigated the therapeutic potential of a novel compound herbal formulation, with a focused evaluation of its clinical efficacy and safety profile in the management of acute pancreatitis (AP).</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 363 acute pancreatitis (AP) patients, stratified into two cohorts: 235 patients receiving traditional Chinese medicine (TCM) intervention, and 128 patients allocated to the control group. Both cohorts received standardized therapeutic interventions upon hospitalization. Clinical parameters including time to first defecation, admission intra-abdominal pressure, C-reactive protein (CRP) levels, postoperative intra-abdominal pressure at 48-hour intervals, incidence of adverse reactions and complications, and prognostic outcomes were systematically monitored and recorded throughout the treatment course.</div></div><div><h3>Results</h3><div>The clinical investigation demonstrated that patients administered a TCM-based therapeutic regimen exhibited significantly accelerated time to first bowel movement compared with the control cohort following hospital admission (p&lt;0.001). Comparative analysis revealed no statistically significant intergroup differences in abdominal pressure reduction, C-reactive protein (CRP) levels, or clinical recovery status at baseline assessment. However, subsequent to 48 hours of therapeutic intervention, the TCM group demonstrated statistically superior reductions in both intra-abdominal pressure (p&lt;0.001) and serum CRP concentrations (p&lt;0.001) relative to conventional treatment recipients. Notably, the TCM intervention cohort exhibited a significantly lower incidence of adverse reactions and post-treatment complications (p&lt;0.001) .</div></div><div><h3>Conclusion</h3><div>The treatment group administered TCM, a Chinese herbal compound formulation, exhibited significantly superior clinical efficacy in multiple outcome measures compared to conventional therapy. Specifically, TCM demonstrated enhanced constipation relief, more substantial reduction in inflammatory markers, greater mitigation of intra-abdominal pressure, and lower incidence of adverse reactions during acute pancreatitis management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese phytopharmacology for gastritis - A systematic review of high-quality randomized controlled trials 中国植物药理学治疗胃炎-高质量随机对照试验的系统综述
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-24 DOI: 10.1016/j.prmcm.2025.100631
Carla Cardiga , Alexandre Constantino , Catarina Fonseca , Daniela Silva , Isabel Teixeira , Jorge Magalhães Rodrigues
{"title":"Chinese phytopharmacology for gastritis - A systematic review of high-quality randomized controlled trials","authors":"Carla Cardiga ,&nbsp;Alexandre Constantino ,&nbsp;Catarina Fonseca ,&nbsp;Daniela Silva ,&nbsp;Isabel Teixeira ,&nbsp;Jorge Magalhães Rodrigues","doi":"10.1016/j.prmcm.2025.100631","DOIUrl":"10.1016/j.prmcm.2025.100631","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastritis is a highly prevalent condition, often lifelong, affecting a substantial portion of the global population. It is estimated that over half of all people experience some degree of chronic gastritis, representing hundreds of millions of individuals worldwide. This systematic review evaluates the efficacy and safety of Chinese phytopharmacological interventions for chronic gastritis, including atrophic and non-atrophic subtypes.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Cochrane Library, Embase, ScienceDirect, and EuropePMC up to November 2024. Only high-quality randomized controlled trials (RCTs) (Jadad score ≥3) were included. Data on characteristics, interventions, comparators, dosages, and key findings interventions were extracted and synthesized.</div></div><div><h3>Results</h3><div>Six RCTs involving 1,195 patients were included. For <em>Helicobacter pylori</em>-negative atrophic gastritis, <em>Piwei Peiyuan</em> prescription and <em>Yiwei Xiaoyu</em> granules significantly improved atrophy and intestinal metaplasia (e.g., <em>Piwei Peiyuan:</em> 64 % improvement in gastric angle atrophy, <em>p</em> = 0.034). In <em>H. pylori</em>-positive cases, <em>Weiwei</em> granules + quadruple therapy achieved higher eradication rates and better histological outcomes than conventional treatment alone. In non-atrophic gastritis, <em>Qirui Weishu</em> capsules led to greater symptom resolution than <em>Sanjiu Weitai</em> (<em>p</em> &lt; 0.01), and <em>Houtou Jianweiling</em> tablets were comparable to omeprazole in efficacy and safety.</div></div><div><h3>Conclusion</h3><div>High-quality evidence from RCTs indicates that several Chinese herbal formulations—such as <em>Piwei Peiyuan</em> prescription, <em>Yiwei Xiaoyu</em> granules, and <em>Qirui Weishu</em> capsules—are effective in alleviating symptoms and improving histopathological outcomes in chronic gastritis, with safety profiles comparable to conventional treatments. These findings support the clinical potential of Chinese phytopharmacology, particularly in improving histological outcomes and alleviating symptoms like epigastric pain and dyspepsia, as standalone or adjunctive therapy. However, these results should be interpreted with caution due to variations in dosing, limited placebo use, and short follow-up periods across studies</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on mechanism of Miao medicine Xinnao Liantong capsule in treatment of myocardial ischemia diseases based on network pharmacology and molecular docking 基于网络药理学和分子对接的苗药心脑连通胶囊治疗心肌缺血的作用机制研究
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-20 DOI: 10.1016/j.prmcm.2025.100629
Yuan Yao , Huan Zhang , Na Zhan , Yong Deng , Jianyong Zhang
{"title":"Study on mechanism of Miao medicine Xinnao Liantong capsule in treatment of myocardial ischemia diseases based on network pharmacology and molecular docking","authors":"Yuan Yao ,&nbsp;Huan Zhang ,&nbsp;Na Zhan ,&nbsp;Yong Deng ,&nbsp;Jianyong Zhang","doi":"10.1016/j.prmcm.2025.100629","DOIUrl":"10.1016/j.prmcm.2025.100629","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the mechanism of Miao Medicine Xinnao Liantong Capsule (XNLTC) in treating myocardial ischemia (MI) using network pharmacology and molecular docking techniques.</div></div><div><h3>Methods</h3><div>Active components of XNLTC were screened from the TCMSP, TCMBANK, and HERB databases, followed by target prediction using SwissTargetPrediction. MI-related targets were obtained from the GEO, GeneCards, and OMIM databases. A \"herb-active components-intersection targets\" network was constructed, and protein-protein interaction analyses were performed using Cytoscape and STRING. Functional enrichment analyses were performed using DAVID, and molecular docking was employed to validate core component-target interactions.</div></div><div><h3>Results</h3><div>Network analysis revealed 282 bioactive components in XNLTC interacting with 1,131 targets and 3,232 MI-related targets. Seven core components (quercetin, eleutheroside B, rutin, puerarin, polydatin, salvianolic acid B, and scutellarin) and six key targets (AKT1, SRC, STAT3, MAPK1, and MAPK3) were identified. Pathway analysis demonstrated significant modulation of lipid metabolism and atherosclerosis, apoptosis, as well as fluid shear stress and atherosclerosis signaling pathways. All binding energies were less than −5.0 kcal/mol, confirming stable molecular interactions.</div></div><div><h3>Conclusions</h3><div>XNLTC exerts therapeutic effects against MI by modulating key pathways, including lipid metabolism and atherosclerosis, apoptosis, and fluid shear stress and atherosclerosis. These findings validate its clinical potential and provide mechanistic insights into the applications of traditional medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100629"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Cassia auriculata-derived silver nanoparticles as a novel male contraceptive agent” “木耳决明子衍生纳米银作为新型男性避孕药”
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-16 DOI: 10.1016/j.prmcm.2025.100626
Prity Yadav , Neha Bharti , Phulwanti Kumari Sharma , Pratap Chand Mali
{"title":"“Cassia auriculata-derived silver nanoparticles as a novel male contraceptive agent”","authors":"Prity Yadav ,&nbsp;Neha Bharti ,&nbsp;Phulwanti Kumari Sharma ,&nbsp;Pratap Chand Mali","doi":"10.1016/j.prmcm.2025.100626","DOIUrl":"10.1016/j.prmcm.2025.100626","url":null,"abstract":"<div><h3>Introduction</h3><div>The development of male contraception remains a crucial area of research in reproductive health. Nanotechnology offers innovative solutions, with plant-derived nanoparticles emerging as potential antifertility agents. This study explores the antifertility effects of <em>Cassia auriculata</em>-derived silver nanoparticles (AgNPs) as a novel approach to male contraception. <em>Cassia auriculata</em>, a medicinal plant with known therapeutic properties, plants of the genus Cassia are used mainly in traditional Chinese medicine (TCM) to control type 2 diabetes, skin and wound healing, as a mild laxative, and for urinary tract health, with active constituents including 1-Tetradecanol, Anthraquinone, Emodin, Quercetin-3-glucoside, β-sitosterol, Rutin, β-sitosterol-β-D-glucoside, was utilized for the green synthesis of AgNPs, ensuring eco-friendliness and biocompatibility.</div></div><div><h3>Methods</h3><div>The synthesized nanoparticles were characterized using UV-Vis spectroscopy, XRD (X-Ray diffraction), FTIR (Fourier Transform Infra-Red), DLS (Dynamic Light Scattering), Zeta Potential, and SEM (Scanning Electron Microscopy) to confirm their physicochemical properties.</div></div><div><h3>Results</h3><div>In vivo studies on male albino rats revealed significant reductions in sperm density and motility, alongside alterations in testicular and epididymal histology, indicating impaired spermatogenesis. Hormonal analysis showed a decline in testosterone levels, further supporting the antifertility potential of these nanoparticles. Importantly, toxicity assessments confirmed minimal systemic side effects, highlighting their safety profile.</div></div><div><h3>Discussion</h3><div>The findings suggest that <em>Cassia auriculata</em>-derived AgNPs could be a promising non-hormonal male contraceptive with reversible effects. This research underscores the potential of nanotechnology in reproductive health and paves the way for further clinical investigations into plant-based nanoparticle contraceptives.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysbioactive, hepato-haematological and biochemical systemic health implications of Zingiber officinale Roscoe: an experimental model 抗生物活性,肝血液学和生化系统健康影响:实验模型
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-16 DOI: 10.1016/j.prmcm.2025.100627
Patience O Adomi , Bright E Igere , Anthony Jude Anozie , Ubreye B Owhe-Ureghe
{"title":"Dysbioactive, hepato-haematological and biochemical systemic health implications of Zingiber officinale Roscoe: an experimental model","authors":"Patience O Adomi ,&nbsp;Bright E Igere ,&nbsp;Anthony Jude Anozie ,&nbsp;Ubreye B Owhe-Ureghe","doi":"10.1016/j.prmcm.2025.100627","DOIUrl":"10.1016/j.prmcm.2025.100627","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the presumed diverse bioactivity of <em>Zingiber officinale roscoe</em> (ginger) in culinary, folkloric and traditional Chinese and alternative medicine, it has emerged as a focus of research with a view to understand its impact on hepatic-haematological indices, biochemical markers, tissue histology, and gastrointestinal microbiota. Jiang as ginger is called in Traditional Chinese Medicine (TCM) has been applied in cold related infection cases, osteo/rheumatoid arthritis, bowel inflammation cases etc. Suffice it to say that the gastrointestinal tract, being an important site of food receipt, nutrient absorption and immune modulation, it is influenced significantly by dietary and phytochemical interventions, including ginger. However, the underlying implications by which ginger affects systemic health and its specific impact on haematological and biochemical markers remain unattended. This study explores the dysbioactive/multifaceted implications of ginger on gut miicrobiota and its impact on hepato-hematological and systemic health indices using experimental models. It also evaluate/establish the preventive/therapeutic, alternative medicinal and TCM potentials of ginger.</div></div><div><h3>Methods</h3><div>Basic and standard microbiological, histological and biochemical approach were employed while sampling forty male albino rats of approximately 12–18 weeks old (130–150 g) and treated with varying concentration of ginger crude water extract.</div></div><div><h3>Results</h3><div>results revealed distinct variations in bacterial profiles across different weeks in relation to the applied treatments compared to the control group, which indicates dysbiotic activity of ginger. A similar and significant (<em>p</em> &gt; 0.01) dysbiotic effect was observed for gut heterotrophic coliform count, while revealing impact on hepatocyte and haematological indices following the dosage applied.</div></div><div><h3>Discussion</h3><div>An investigation into the optimal dosage and concentration of ginger to achieve effective health benefits is suggestive in enhancing hepto-hematological, gastrointestinal health and overall well-being especially as applied in modern Chinese medicine (MCM) and TCM for the production of some seasoning agents as well as white ginger sushi, ginger soy sauce and the white pickled ginger slice etc., as food additive to improve wellbeing.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research status and prospects of Chinese medicine herb Asparagus cochinchinensis 中药芦笋的研究现状与展望
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-05-11 DOI: 10.1016/j.prmcm.2025.100625
Miao Liu , Liu Tang , Yongquan Li , Gonggu Lv , Ming-sheng Zhang
{"title":"Research status and prospects of Chinese medicine herb Asparagus cochinchinensis","authors":"Miao Liu ,&nbsp;Liu Tang ,&nbsp;Yongquan Li ,&nbsp;Gonggu Lv ,&nbsp;Ming-sheng Zhang","doi":"10.1016/j.prmcm.2025.100625","DOIUrl":"10.1016/j.prmcm.2025.100625","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Asparagus cochinchinensis</em> (Lour.) Merr (<em>A. cochinchinensis</em>) well known as traditional Chinese medicinal herb, listed as a homology of medicine and food. It has long been employed in medical applications, including anti-cancer, antibacterial, anti-inflammatory, antioxidant, and anti-aging treatments. In recent years, its edible, feeding, and ornamental values have also attracted widespread attention.</div></div><div><h3>Methods</h3><div>A comprehensive review of scientific databases, including Scopus, PubMed, Web of Science, and the National Knowledge Infrastructure of China, was conducted to gather comprehensive insights. The keywords used included \"<em>A. cochinchinensis</em>\", \"resource distribution\" \"pharmacological properties\" and \"associated quality control\". Studies from both outdoor analysis and in vivo experiments were considered, ensuring a well-rounded evaluation of the herb’s effects.</div></div><div><h3>Results</h3><div>Currently, <em>A. cochinchinensi</em>s is widely distributed in China, mainly in <em>Guizhou, Sichuan</em>, and <em>Yunnan</em> as the main production areas, and usually relies on tissue culture technology for manufacturing purposes. The primary pharmacological characteristics are thought to stem from its saponin and polysaccharide elements present in vivo. Research indicates that <em>A. cochinchinensis</em> exhibits properties of antibacterial agents, reducing inflammation, combating aging, and curbing tumours. Moreover, its alleviation of depression and Alzheimer's disease has ignited curiosity about its possible therapeutic uses. Moreover, its proven nutritional worth has boosted public research and development in the by-products.</div></div><div><h3>Discussion</h3><div>The pharmacological impacts of various <em>A. cochinchinensis</em> origins and sources might differ, and the regulatory routes of saponins and polysaccharides, mainly responsible for these effects, remain ambiguous. Concurrently, additional clinical information is required to substantiate the pharmacological impact of <em>A. cochinchinensis</em>. Consequently, additional studies are imperative regarding the application and safety aspects of herbal medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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