Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Unveiling the potential of Chinese herbs in combating cervical cancer: Understanding their mechanisms of action and herbal formulations","authors":"Priyanka Ray,&nbsp;Diptayan Paul","doi":"10.1016/j.prmcm.2024.100497","DOIUrl":"10.1016/j.prmcm.2024.100497","url":null,"abstract":"<div><h3>Introduction</h3><p>Within the framework of Traditional Chinese Medicine (TCM), this study investigates the vast field of Chinese herbal medicine's potential as a powerful weapon in the fight against cervical cancer.</p></div><div><h3>Methods</h3><p>A thorough search was made through Scopus, PubMed, ResearchGate, and Elsevier Journals for future studies on the healing and cervical cancer-fighting properties of Chinese plants and herbal formulations.</p></div><div><h3>Result</h3><p><em>Scutellaria baicalensis, Curcuma longa, Ganoderma lucidum, Camptotheca acuminata, Antrodia cinnamomea, Terminalia catappa, Chelidonium majus, Lycopodium clavatum,</em> and <em>Myrica cerifera</em> possess cancer-fighting bioactive compounds. Baicalein in <em>Scutellaria baicalensis</em> suppresses cervical cancer growth and alters Notch signaling, while curcumin in <em>Curcuma longa</em> inhibits cell migration, invasion, and HPV oncogenes, also reducing inflammation and protecting cells. <em>Ganoderma lucidum</em> lowers inflammation, boosts the immune system, and blocks JAK/STAT5 signaling, preventing EMT in cervical cancer cells. Camptothecin in <em>Camptotheca acuminata</em> inhibits DNA topoisomerase I, reducing cancer cell growth, with <em>Antrodia cinnamomea</em> controlling apoptosis. <em>Terminalia catappa</em> uses MMP-9 and MAPK to inhibit spread, while <em>Chelidonium majus, Lycopodium clavatum</em>, and <em>Myrica cerifera</em> induce apoptosis and cell cycle arrest. Zhidai Decoction and Guizhi-Fuling-decoction suggest traditional Chinese medicine can treat HPV and cervical cancer.</p></div><div><h3>Discussion</h3><p><em>Scutellaria baicalensis, Curcuma longa, Ganoderma lucidum, Camptotheca acuminata, Antrodia cinnamomea, Terminalia catappa, Chelidonium majus, Lycopodium clavatum,</em> and <em>Myrica cerifera</em> possess bioactive substances effective against cancer. They work through mechanisms like inhibiting cell growth, altering signaling pathways, and inducing apoptosis. Traditional Chinese medicine formulations like Zhidai Decoction and Guizhi-Fuling-decoction show potential in treating HPV and cervical cancer.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100497"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001398/pdfft?md5=14758494117125aece7dcfd515fc3b1d&pid=1-s2.0-S2667142524001398-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo components analysis of Shenhua tablets active in IgA nephropathy","authors":"Huiqiang Liu ,&nbsp;Ping Li ,&nbsp;Fengting Yin ,&nbsp;Hui Sun ,&nbsp;Ying Zheng ,&nbsp;Chang Liu ,&nbsp;Xiangmei Chen ,&nbsp;Xiaotong Yan ,&nbsp;Xijun Wang","doi":"10.1016/j.prmcm.2024.100493","DOIUrl":"10.1016/j.prmcm.2024.100493","url":null,"abstract":"<div><h3>Introduction</h3><p>Shenhua Tablet (SH), a traditional Chinese medicine (TCM) formulation with seven herbs, is widely used in the clinical treatment of Immunoglobulin A (IgA) nephropathy. Despite its effectiveness, the specific active components of SH <em>in vivo</em> remain unidentified, presenting a challenge for further research on its pharmacodynamic material basis.</p></div><div><h3>Methods</h3><p>A rat model of IgA nephropathy was treated with Shenhua Tablet (SH) to evaluate its potential in protecting kidney function. UHPLC-Q/Orbitrap/LTQ MS was utilized to identify active components of SH <em>in vivo</em> under the active condition for intervening IgA.</p></div><div><h3>Results</h3><p>SH significantly ameliorated Thy-1 antibody-induced IgA nephropathy by decreasing glomerular injury, suppressing pro-inflammatory factor secretion, and inhibiting mesangial cell proliferation. 83 kinds of prototypal compounds absorbed into the blood were comprehensively characterized, along with 145 metabolites arising from Phase I and Phase II metabolic reactions. and the metabolic pathways of these metabolites were elucidated for the first time. 10 active components were found to be correlated with the effectiveness of SH, including Atractylenolide I, chlorogenic acid, ferulic acid, salidroside+SO₃, calycosin+<em>O</em>, furanodiene, paeoniflorin-H₂, germacron+<em>O</em>, formononetin+C₆H₈O₆, and calycosin.</p></div><div><h3>Discussion</h3><p>The results fill the current research gap on the active components of SH and examine its potential renoprotective effects on IgA nephropathy. This study provides valuable references and insights for elucidating the active components and mechanisms of action of SH in treating IgA nephropathy.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100493"},"PeriodicalIF":0.0,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001350/pdfft?md5=acdeea7ae0f37e0488f016b9fe6b437a&pid=1-s2.0-S2667142524001350-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of bioactivity validation as quality control approach: Panax notoginseng dominated scientific-driven new TCM formulae-BPAid from laboratory to industrial scale","authors":"Wan Yin Tew ,&nbsp;Yean Chun Loh ,&nbsp;Chong Seng Yan ,&nbsp;Hui Wei Loh ,&nbsp;Chen Jingying ,&nbsp;Chen Ying ,&nbsp;Lee Suan Chua ,&nbsp;Guo Longgang ,&nbsp;Xu Wen ,&nbsp;Xu Wei ,&nbsp;Mun Fei Yam","doi":"10.1016/j.prmcm.2024.100496","DOIUrl":"10.1016/j.prmcm.2024.100496","url":null,"abstract":"<div><h3>Background</h3><p>In the realm of Chinese medicine, quality control and pharmacodynamics are crucial to ensure the consistency in scaled-up process from the laboratory to commercial operations. This study aims to analyse bioactivity consistency between laboratory observations and commercial processes.</p></div><div><h3>Method</h3><p>The preparation of BPAid (5: 2: 9: 1 for <em>Uncaria rhynchophylla</em> (UR): <em>Pueraria thomsonii</em> (PT): <em>Panax notoginseng</em> (PN): <em>Alisma orientale</em> (AO) was divided into three methods: laboratory-scale maceration (BPAidM), industrial-scale flash extract method (BPAidFE), decoction method (BPAidD). The vasodilatory and antihypertensive effects of the extracts were examined through <em>ex vivo</em> and <em>in vivo</em> studies. The chemical fingerprint of each extract was analysed using tri-step FTIR spectroscopy, and UPLC-MS/MS was used for standard marker quantification.</p></div><div><h3>Results</h3><p>BPAidM exhibited the highest vasodilatory effect, followed by BPAidFE, and BPAidD with EC₅₀ values of 11.25 ± 2.30 mg/mL, 39.23 ± 12.55 mg/mL, 24.33 ± 6.26 mg/mL, and 198.71 ± 127.21 mg/mL: R_MAX values of 106.53 ± 7.95%, 82.92 ± 5.22%, 76.35 ± 4.51%, and 60.62 ± 5.7%, respectively. In <em>in vivo</em> antihypertensive studies, all extracts significantly reduced the blood pressure of Spontaneously Hypertensive rats (SHRs). The tri-step FTIR revealed the presence of phenolic compounds, esters, and saccharides in BPAid extracts. BPAidM contained the highest total standard marker in the UPLC-MS/MS quantification, followed by BPAidFE, and BPAidD.</p></div><div><h3>Conclusion</h3><p>Ultimately, the flash extract technique is recommended to produce BPAid to meet the global demand.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100496"},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001386/pdfft?md5=13cb2b806d032797a7ae97de11115685&pid=1-s2.0-S2667142524001386-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the therapeutic potential and nanotechnological approaches for the delivery of tanshinone IIA","authors":"Diya Arora,&nbsp;Vanshita,&nbsp;Keshav Bansal","doi":"10.1016/j.prmcm.2024.100494","DOIUrl":"10.1016/j.prmcm.2024.100494","url":null,"abstract":"<div><h3>Introduction</h3><p>Phytochemicals, as dietary ingredients, are being extensively studied for the treatment and prevention of many illnesses. Tanshinone IIA, a plant-derived diterpene quinone has demonstrated various therapeutic effects. However, limitations like low solubility, bioavailability and stability, weak targeting biodistribution, and short half-life make Tan IIA an unlikely candidate for effective therapy. Nanoformulations based on natural substances are gaining interest as a treatment approach for various human diseases, as they provide an effective alternative to conventional approaches, which are frequently linked with a number of adverse effects and complications.</p></div><div><h3>Methods</h3><p>The study comprises a thorough assessment of existing research findings from a variety of sources in order to collect data on Tan IIA therapeutic properties and innovative delivery systems. Literature was compiled from various databases, including Scopus, Embase, PubMed, and Google Scholar, using keywords such as \"Tanshinone IIA\" or \"diterpenes\" in combination with \"Traditional Chinese medicine\", \"Therapeutic potential\", \"Neuroprotection\", \"Anti-cancer\", \"Cardioprotection\", \"Nanocarriers\", or \"Liposomes\".</p></div><div><h3>Results</h3><p>The findings demonstrated that Tan IIA possesses a broad array of pharmacological effects including its antidiabetic, anticancer, antioxidant, and anti-inflammatory activities. Tan IIA nanoformulations have shown good encapsulation efficiency, sustained release, stability, extended circulation duration, increased accumulation at diseased sites, and improved therapeutic efficacy, leading to improved therapeutic effectiveness for a plethora of disorders.</p></div><div><h3>Discussion</h3><p>Nanostructured particles provide several benefits in addressing issues such as limited bioavailability and the stability of phytochemicals by overcoming biological barriers. Certainly, the use of nano-drug delivery carriers for plant products is the current trend. Furthermore, the therapeutic applications of these nanoformulations must be studied in humans. Such investigation, as well as thorough evaluation and dosage optimization, may pave the way for Tanshinone IIA's commercial feasibility.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001362/pdfft?md5=ad2729d280ed1e0f3f6e3d617332dc7a&pid=1-s2.0-S2667142524001362-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrobium nobile alkaloids modulate calcium dysregulation and neuroinflammation in Alzheimer's disease: A bioinformatic analysis","authors":"Iman Touati ,&nbsp;Yassir Boulaamane ,&nbsp;Mohammed Reda Britel ,&nbsp;Amal Maurady","doi":"10.1016/j.prmcm.2024.100495","DOIUrl":"10.1016/j.prmcm.2024.100495","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Dendrobium nobile</em> Lindl alkaloids, or DNLA for short, are the most active ingredients found in <em>D.nobile</em>, a top grade plant in Shen Nong Ben Cao Jing, with an extensive history of medicinal use in Chinese traditional medicine (TCM) as a multifunctional therapeutic agent. Recent evidence has emerged linking the neuroprotective and anti-aging effects of DNLA to their involvement in promoting autophagy of toxic amyloid-β (Aβ) plaques and modulation of key enzymes involved in the hyperphosphorylation of Tau proteins. Although amyloid buildup and the aggregation of Tau proteins are central to the onset of Alzheimer's disease (AD), evidence on how DNLA relate to other overlooked dysregulated AD-associated pathways is still lacking.</p></div><div><h3>Methods</h3><p>We intend on deciphering the underlying mechanisms driving the anti-AD effect of DNLA, using a combination of network analysis based on differentially expressed genes found in AD patients, target fishing, centrality analysis, enrichment analysis and hub genes identification.</p></div><div><h3>Results</h3><p>In total, 2069 genes were found differentially expressed in SRP181886 and a PPI network constructed with common targets between DNLA and AD. Five hub genes were identified having a discriminatory power greater than 0.7; <em>HTR2A, GRIN2B, GABRA1, HTR2C, GRIN2A</em>, with the former being the top bottleneck node in the network. Enrichment analysis found that DNLA exert an anti-AD effect through the regulation of the calcium signaling pathway and the serotonergic system, by modulating key receptors implicated in excitatory/inhibitory neurotransmission. Additionally, DNLA were found to modulate two subunits of NMDA receptor involved in the release of pro-inflammatory cytokines, underlying the possible involvement of DNLA in neuroinflammation.</p></div><div><h3>Discussion</h3><p>This further emphasizes the therapeutic value of <em>D.nobile</em> and the multi-target, multi-pathway potential of DNLA to counteract the deleterious effects of calcium dysregulation and excitatory toxicity in AD, while providing evidence-based rationale behind the traditional use of <em>D. nobile</em> in TCM.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100495"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001374/pdfft?md5=30a5fa8d546223c2b51f20a917fcf638&pid=1-s2.0-S2667142524001374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of cellular stress response pathway system of Rhizoma coptidis","authors":"Alok Batt ,&nbsp;Kuldeep Singh ,&nbsp;Jeetendra Kumar Gupta ,&nbsp;Dilip Kumar Chanchal ,&nbsp;Kamlesh Kumar ,&nbsp;Anubhav Dubey ,&nbsp;Shivendra Kumar ,&nbsp;Divya Jain","doi":"10.1016/j.prmcm.2024.100491","DOIUrl":"10.1016/j.prmcm.2024.100491","url":null,"abstract":"<div><h3>Introduction</h3><p>Cellular stress responses play a crucial role in maintaining cellular homeostasis and combating various pathological conditions. Understanding the stress response mechanisms triggered by <em>R. coptidis</em> is critical for harnessing its therapeutic potential. This herb is widely used, but the precise cellular mechanisms through which it exerts its therapeutic effects remain less explored. This review aims to elucidate how <em>R. coptidis</em> affects key cellular pathways and its potential as a therapeutic agent.</p></div><div><h3>Method</h3><p>This review examines existing evidence on the cellular mechanisms and stress response pathways influenced by <em>R. coptidis</em>. The analysis focuses on the regulation of NF-κB, MAPK, PI3K-Akt, AMPK, ERS, and oxidative stress pathways. Sources include peer-reviewed articles, clinical studies, and traditional Chinese medicine (TCM) literature.</p></div><div><h3>Results</h3><p>Evidence indicates that <em>R. coptidis</em> exerts beneficial effects on various diseases by modulating the NF-κB, MAPK, PI3K-Akt, AMPK, ERS, and oxidative stress pathways. By targeting these pivotal pathways, <em>R. coptidis</em> mitigates cellular damage and restores homeostasis under pathological conditions.</p></div><div><h3>Conclusion</h3><p>Understanding the cellular stress response and molecular mechanisms of <em>R. coptidis</em> highlights its multifaceted therapeutic potential. These findings underscore the importance of integrating TCM approaches into modern therapeutic strategies for combating complex diseases. Further investigations into the molecular targets and clinical efficacy of <em>R. coptidis</em> are needed to fully realize its therapeutic potential.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100491"},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001337/pdfft?md5=56129e86139784f8c1959fd95b3a5e35&pid=1-s2.0-S2667142524001337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Exploring the potential mechanism of Dayuanyin in treating acute lung injury: A network pharmacology and experimental verification approach” [Pharmacological Research - Modern Chinese Medicine, Volume 12, September 2024, 100483]","authors":"Bei Huang ,&nbsp;Wen Zhang ,&nbsp;Rui Li ,&nbsp;Yifei Xie ,&nbsp;Haiguang Yang ,&nbsp;Junke Song ,&nbsp;Xiaobin Pang ,&nbsp;Guanhua Du","doi":"10.1016/j.prmcm.2024.100489","DOIUrl":"10.1016/j.prmcm.2024.100489","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001313/pdfft?md5=3fb71bba380ed22f4b4004d3d835b373&pid=1-s2.0-S2667142524001313-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of Hibiscus sabdariffa var. altissima on cerebral ischemia‒Reperfusion injury in rats","authors":"Adjia Hamadjida ,&nbsp;Saida Nkuketgnigni Njemguie ,&nbsp;Rigobert Espoir Ayissi Mbomo ,&nbsp;Stephen Nkengbang Foudjih ,&nbsp;Véronique France Prisca Amayapa ,&nbsp;Jean Pierre Kilekoung Mingoas ,&nbsp;Fidèle Ntchapda","doi":"10.1016/j.prmcm.2024.100485","DOIUrl":"10.1016/j.prmcm.2024.100485","url":null,"abstract":"<div><h3>Background</h3><p><em>Hibiscus sabdariffa</em> var. <em>altissima</em>, which is known for its high-quality fiber, is commonly used in Traditional Chinese Medicine (TCM) for its diuretic, choleretic, analgesic, antitussive, and hypotensive effects. Furthermore, the flowers have been used to treat diabetes, hypertension, atherosclerosis, and obesity. However, there are no studies assessing its neuroprotective effects on cerebral ischemia, unlike the <em>sabdariffa</em> variety known for its neuroprotective effects. Therefore, this study was aimed to investigate the potential efficacy of <em>Hibiscus sabdariffa</em> var. <em>altissima</em> extract (HAS) and its underlying mechanism on oxidative stress and neuroinflammation during cerebral ischemia-reperfusion (I/R) injury.</p></div><div><h3>Methods</h3><p>A model of cerebral ischemia was established in male Wistar rats through middle cerebral artery occlusion (MCAO) and reperfusion. Rats were randomly divided into the sham, IR, IR + HSA100, IR + HSA200, IR + HSA400 and IR + Eda groups and were treated for 14 consecutive days. The neurological deficit score and the cylinder test were performed to assess neurological impairment. Oxidative stress was determined by measuring the levels of malondialdehyde (MDA) and antioxidant markers such as reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were measured to evaluate antioxidant activities. In addition, the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), were also determined.</p></div><div><h3>Results</h3><p>Our results demonstrated that HSA significantly ameliorated neurological impairment and reduced the volume of brain infarct. HSA also decreased the levels of MDA and enhanced the antioxidant activities of GSH, SOD and CAT in brain tissues. Furthermore, HSA decreased the expression of the proinflammatory cytokines TNF-α, IL-1β and IL-6 in the serum.</p></div><div><h3>Conclusion</h3><p>These findings demonstrated that HSA exhibited a potential neuroprotective effect against cerebral I/R injury, possibly by improving oxidative stress and attenuating inflammatory responses. Therefore, HSA could be used as a potential therapeutic option for cerebral ischemic injuries.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100485"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001271/pdfft?md5=643326dce8d822fdffb9460f41429f24&pid=1-s2.0-S2667142524001271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective action of hordenine against the Aluminium Chloride (AlCl3) induced Alzheimer's diseases & associated memory impairment in experimental rats","authors":"Mohit Agrawal ,&nbsp;Manmohan Singhal ,&nbsp;Bhupesh Chander Semwal ,&nbsp;Swamita Arora ,&nbsp;Bhoopendra Singh ,&nbsp;Vandana Sikarwar ,&nbsp;Pranshul Sethi ,&nbsp;Hema Chaudhary ,&nbsp;Wasim Akram ,&nbsp;Samir Bhargva ,&nbsp;Bhavna Kumar ,&nbsp;Sunam Saha ,&nbsp;Shivendra Kumar","doi":"10.1016/j.prmcm.2024.100492","DOIUrl":"10.1016/j.prmcm.2024.100492","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the neuroprotective action of hordenine against the cognitive dysfunction induced by aluminium chloride (AlCl₃) in Wistar rats</p></div><div><h3>Methodology</h3><p>Rats were given oral doses of hordenine (25 and 50 mg/kg), donepezil (5 mg/kg), and AlCl₃ (175 mg/kg) for 28 days. During the study, neurobehavioral parameters included Morris water maze (MWM), open field test (OFT), and novel object recognition test <strong>(</strong>NORT) to assess the cognitive effect. On the 29th day rats were sacrificed and brain tissues removed for biochemical and histopathological analyses.</p></div><div><h3>Results</h3><p>AlCl₃ rats exhibited altered neurobehavioral patterns and cognitive impairment in experimental rats. Although AlCl₃ raised the levels of mid-brain acetylcholinesterase (AChE), lipid peroxidation (LPO), nitrite, tumour necrosis factor-α (TNF-α), interleukin-β (IL-β), nuclear factor-kappa B (NF-κB), brain-derived neurotrophic factor (BDNF), and it decreased the levels of antioxidants including glutathione (GSH), catalase, superoxide dismutase (SOD), and body weight. In cortical and hippocampal slices, AlCl₃ also revealed anatomical alterations that resulted in a decrease in the density of microglia. But donepezil and hordenine reversed these alterations to normal while demonstrating a neuroprotective effect against AD which is caused by AlCl₃.</p></div><div><h3>Conclusion</h3><p>Hordenine improved memory and other cognitive functions, demonstrating a neuroprotective effect against AlCl₃-induced Alzheimer's disease. These findings imply that hordenine may be able to reverse the effects of oxidative stress and neuroinflammation, improve cognitive decline, and protect the brain's histological structure.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001349/pdfft?md5=77b08aefd70644a1a3f91ac83de4b82b&pid=1-s2.0-S2667142524001349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “The efficacy of Panax ginseng in obesity and the related metabolic disorders” [Pharmacological Research - Modern Chinese Medicine, Volume 1, December 2021, 100013]","authors":"Charalampia Amerikanou,&nbsp;Andriana C. Kaliora,&nbsp;Aristea Gioxari","doi":"10.1016/j.prmcm.2024.100490","DOIUrl":"10.1016/j.prmcm.2024.100490","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100490"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001325/pdfft?md5=21c5d04f345ef28af340c24a931e1157&pid=1-s2.0-S2667142524001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}