芹菜素的医学和生物学作用综述

Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-01-21 DOI:10.1016/j.prmcm.2025.100576

Mayukh Bhattacharya , Shyamapada Mandal

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引用次数: 0

摘要

黄酮结构类植物源性生物活性化合物包括APGN（芹菜素），4,5和7-三羟基黄酮。在中医中，APGN备受关注。本研究以综述为基础，旨在揭示APGN在其医学和生物学作用方面的各种观点，重点是抗感染和抗炎活性，考虑到各种含APGN的植物性中药配方。方法采用“中药”、“抗感染”、“炎症”、“中医”等关键词进行综合检索。在这篇综述中使用的其他几个关键词包括“秦皮堂”、“舒干湾”和“Lóng Dǎn Xiè Gān Tāng”。从NCBI-PubMed或b谷歌Scholar数据库中挖掘了1994年至2024年间在不同期刊上发表的有关上述领域的科学文章，以完成当前的审查。结果文献综述发现，APGN对多种炎症及细菌、真菌和病毒感染具有良好的治疗效果。作为中药使用的APGN的组合配方是这里破译的有价值的见解之一。化合物APGN具有广泛的治疗功效。阐述了富apgn的中药配方及其应用。它们显示出抗感染和抗炎的潜力。类似地，“蜀干湾”（SGW）和“Lóng Dǎn Xiè Gān Tāng”（LDZGT），包括其他一些，也在讨论中。APGN作为神经保护剂和免疫调节剂的作用是本综述强调的有价值的见解之一。讨论了如何解决APGN以纳米载体形式存在的生物利用度限制。本文给出了中医专用术语及其简要描述，以方便学术读者阅读。本文讨论了APGN的抗氧化和抗癌特性，并引用了各种临床试验。最后，对该领域存在的研究空白进行了综述。解决对APGN作为生物活性化合物的进一步研究需要，是更新APGN的医学和生物活性的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Medical and biological role of Apigenin: A comprehensive review

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Medical and biological role of Apigenin: A comprehensive review

Introduction

The plant-derived bioactive compounds from the flavone structural class include APGN (apigenin), the 4, 5, and 7-trihydroxyflavone. In the traditional Chinese medicine (TCM), APGN has drawn much attention. This review-based study aims to unveil various perspectives of APGN in connection to its medical and biological roles with emphasis on anti-infective and anti-inflammatory activities, considering various APGN containing plant-based TCM formulations.

Methods

A thorough review of literatures was performed using various combinations of keywords, including 'Chinese medicine,' 'APGN against infection,' 'inflammation,' and TCM. A few of the other keywords that were used in this review included 'Qin Pi Tang,' 'Shu Gan Wan,' and 'Lóng Dǎn Xiè Gān Tāng. The scientific articles on the mentioned fields, published between the years 1994 and 2024 in different journals, were mined from NCBI-PubMed or Google Scholar databases to accomplish the current review.

Results

The literature review found that APGN possesses promising therapeutic benefits against various inflammations and bacterial, fungal, and viral infections. Combinational formulations of APGN used as TCM are one of the valuable insights that were deciphered here.

Discussion

The compound APGN possesses a broad spectrum of therapeutic efficacy. APGN-rich TCM-specific formulations and their applications are elaborated. They revealed anti-infective and anti-inflammatory potential. Similarly, 'Shu Gan Wan’ (SGW) and 'Lóng Dǎn Xiè Gān Tāng’ (LDZGT) including a few others, are being discussed. The role of APGN as a neuro-protectant and immune-modulatory agent is one of the valuable insights highlighted in this review. The way to address the bioavailability limitations of APGN in the form of nano-carriers has been discussed. TCM-specific terms and their brief descriptions were given in this review for better accessibility to scholarly audiences. The anti-oxidative and anticancer properties of APGN were discussed, and various clinical trials were cited in this review. Finally, this review emphasized the existing research gaps in the field. Addressing the further need for study on APGN as a bioactive compound is essential to update the medical and biological activities of APGN.

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来源期刊

Pharmacological Research - Modern Chinese Medicine

CiteScore

1.60

自引率

0.00%

发文量