Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Anticoagulant peptides derived from animal-sourced traditional Chinese medicine and their pharmacological effects","authors":"Ran Liu ,&nbsp;Yichen Ding ,&nbsp;Xinyan Jiang ,&nbsp;Ruijuan Dong ,&nbsp;Yuting Zhang ,&nbsp;Yutong Hua ,&nbsp;Cong Gai ,&nbsp;Peng Wei","doi":"10.1016/j.prmcm.2024.100529","DOIUrl":"10.1016/j.prmcm.2024.100529","url":null,"abstract":"<div><h3>Introduction</h3><div>Peptide drugs are highly regarded for their therapeutic versatility, safety, and efficacy in treating conditions like cancer, hepatitis, and diabetes. Animal-derived Traditional Chinese Medicines (TCMs) are promising peptide sources, often outperforming plant-based alternatives. The therapeutic effects of leeches, earthworms, and <em>Eupolyphaga sinensis Walkers</em> in thrombosis and blood stasis have been clinically validated, with anticoagulant peptides as key components; however, their pharmacological mechanisms remain unclear. This review categorizes and summarizes anticoagulant peptides from animal-derived TCMs by species.</div></div><div><h3>Methods</h3><div>This study explores the important role of anticoagulant peptides from animal-sourced medicine in treating thrombosis-related diseases. A literature search using keywords like “anticoagulant peptides,” “leech peptides,” and “earthworm peptides” yielded over 120 articles, of which 85 were selected. Priority was given to studies from the past 20 years, while significant historical research was also noted. Articles lacking specific information on the animal sources of these peptides were excluded. Data were obtained from a diverse range of references, including both ancient and modern texts, the Chinese Pharmacopoeia, Web of Science, PubMed, ScienceDirect, Google Scholar, Springer, and CNKI.</div></div><div><h3>Conclusion</h3><div>This study reviews six promising animal-derived anticoagulant drugs currently in clinical use: leeches, earthworms, scorpions, <em>Eupolyphaga sinensis Walkers</em>, and centipedes. Key peptides under development include hirudin (<em>Hirudo nipponica</em>), WP-30 (<em>Whitmania pigra</em>), Lomburkinase (<em>Eisenia foetida</em>). These peptides exhibit potent anticoagulant, antiplatelet, and anti-inflammatory effects, rendering them valuable in the treatment of cardiovascular diseases, stroke, amenorrhea, cerebral thrombosis, and atherosclerosis.</div></div><div><h3>Discussion</h3><div>This study critically evaluates the therapeutic mechanisms of anticoagulant peptides in animal-sourced medicines, emphasizing the potential of peptide-based therapies across different strains of the same species for traditional Chinese medicine and modern clinical use. Despite promising potential, challenges such as low bioavailability, difficulties in peptide identification, pharmacological evaluation, and toxicity assessment persist. Addressing these issues will facilitate deeper exploration and development of peptide-based therapies.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100529"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer","authors":"Karthik K Karunakar ,&nbsp;Binoy Varghese Cheriyan ,&nbsp;Ramaiyan Velmurugan ,&nbsp;Meenaloshini Gopalakrishnan ,&nbsp;Karthikha VS","doi":"10.1016/j.prmcm.2024.100527","DOIUrl":"10.1016/j.prmcm.2024.100527","url":null,"abstract":"<div><h3>Background</h3><div>Hinokitiol (β-thujaplicin), a naturally occurring tropolone derivative, exhibits multifaceted pharmacological properties. The aim of this review is to explore the medicinal potential of hinokitiol in different biological systems.</div></div><div><h3>Objectives</h3><div>To systematically investigate hinokitiol's anti-inflammatory, antimicrobial, and antineoplastic properties; explore its molecular mechanisms of action; determine its toxicological profile; and future research.</div></div><div><h3>Methods</h3><div>We conducted a search on PubMed, Scopus, and Web of Science for research publications. Initially, we recognized 300 studies. Following a comprehensive analysis, 186 studies reported the pharmacological properties of hinokitiol. We excluded articles that either lacked experimental rigor or provided insufficient mechanistic insight.</div></div><div><h3>Results</h3><div>Hinokitiol demonstrates significant anti-inflammatory effects through modulation of NF-κB, MAPK, and associated signaling cascades. Its broad-spectrum antimicrobial activity has bactericidal, fungicidal, and antiviral properties, with unique mechanisms of action that may circumvent conventional resistance pathways. Anticancer effects have been observed in multiple neoplastic cell lines and animal models, including breast, lung, endometrial, and hepatocellular carcinomas, mediated through induction of apoptosis, cell cycle arrest, and modulation of autophagic processes. Additional studies indicate antioxidant, neuroprotective, and dermatological benefits. Toxicological assessments suggest favorable tolerability at therapeutic doses, though comprehensive human safety data remain limited.</div></div><div><h3>Conclusions</h3><div>Hinokitiol shows significant potential for treating infections, inflammation, and cancers by targeting key cellular pathways. However, further research is needed to optimize its dosage, ensure safety, and improve bioavailability for clinical use. While promising, more studies are required to translate its preclinical success into effective therapies.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Note on “Salvianolic acids for injection alleviates cerebral ischemia-induced neurodegeneration by inhibiting endoplasmic reticulum stress and neuroinflammation” [PRMCM, 6 (2023) 100211]","authors":"Wen Zhang ,&nbsp;Sen Zhang ,&nbsp;Haiguang Yang ,&nbsp;Yangyang He ,&nbsp;Xue Zhang ,&nbsp;Rong Yan ,&nbsp;Junke Song ,&nbsp;Xiaobin Pang ,&nbsp;Guanhua Du","doi":"10.1016/j.prmcm.2024.100526","DOIUrl":"10.1016/j.prmcm.2024.100526","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of echinoside on MPTP-induced Parkinson's disease mouse model by activation of NRF2/HO-1 pathway","authors":"Zimeng Li ,&nbsp;Hongyan Li","doi":"10.1016/j.prmcm.2024.100525","DOIUrl":"10.1016/j.prmcm.2024.100525","url":null,"abstract":"<div><div>Echinacoside, a principal active compound derived from <em>Cistanche deserticola</em> Ma, is recognized in traditional Chinese medicine for its anti-aging, immunomodulatory, endocrine-regulating, and neuroprotective properties. However, the specific neuroprotective mechanisms of echinacoside remain largely unclear. This study aims to investigate whether the neuroprotective effects of echinacoside in a mouse model of Parkinson's disease (PD) are mediated through the Nrf2/HO-1 signaling pathway by mitigating inflammatory responses. Mice were divided into four groups: control, model, positive control, and echinacoside-treated groups. PD mouse model was induced through intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) over the course of one week, followed by three weeks of oral administration of echinacoside. The results demonstrated that echinacoside significantly improved motor function impairments caused by MPTP in PD mice. Immunohistochemical analysis revealed that echinacoside enhanced the expression of tyrosine hydroxylase in the substantia nigra of PD mice. Furthermore, assays of inflammatory cytokines indicated that echinacoside effectively reduced the levels of IL-6 and TNF-α in brain tissues. Western blot analysis further confirmed that echinacoside intervention upregulated the expression of Nrf2 and HO-1 in the brain tissues of PD mice. These findings suggest that echinacoside exerts neuroprotective effects in the PD mouse model, likely through the activation of the Nrf2/HO-1 signaling pathway. Therefore, echinacoside may be considered a potential therapeutic strategy for the treatment of PD.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Xiaoshuan Tongluo recipe alleviated acute hyperglycemia-enhanced hemorrhagic transformation by regulating microglia polarization in thromboembolic stroke rats” [Pharmacological Research - Modern Chinese Medicine (2023) 100315]","authors":"Zirong Pan ,&nbsp;Nannan Liu ,&nbsp;Guodong Ma ,&nbsp;Sen Zhang ,&nbsp;Chengdi Liu ,&nbsp;Ziyuan Zhao ,&nbsp;Linglei Kong ,&nbsp;Guanhua Du","doi":"10.1016/j.prmcm.2024.100520","DOIUrl":"10.1016/j.prmcm.2024.100520","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100520"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Investigating the mechanisms of Xiaoyaosan on premenstrual dysphoric disorder using metabolomics technology” [Pharmacological Research - Modern Chinese Medicine 10C (2024) /100398] 2","authors":"Mengbai Xu ,&nbsp;Yueyun Liu ,&nbsp;Chenyue Liu ,&nbsp;Zhe Xue ,&nbsp;Jianbei Chen ,&nbsp;Yanfen Liu ,&nbsp;Jiaxu Chen","doi":"10.1016/j.prmcm.2024.100514","DOIUrl":"10.1016/j.prmcm.2024.100514","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100514"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative study to determine the anti-tumor role and mechanism of Chouchunpi San in colorectal cancer","authors":"Nuolin Shi ,&nbsp;Mingjie Li ,&nbsp;Xuehui Li ,&nbsp;Xinxin Hou ,&nbsp;Mingzhu Wang ,&nbsp;Zhongya Ni ,&nbsp;Shan Lin ,&nbsp;Liang Hu ,&nbsp;Fuwen Yuan","doi":"10.1016/j.prmcm.2024.100524","DOIUrl":"10.1016/j.prmcm.2024.100524","url":null,"abstract":"<div><h3>Introduction</h3><div>The herbal formula Chouchunpi San (CCPS) is a traditional formula that has been widely used and proven effective in various clinical cancer treatments. However, the mechanism of its anticancer effect remains unclear. This study aims to determine the anti-tumor effect of CCPS on colorectal cancer (CRC) <em>in vivo</em> and <em>in vitro</em> and to explore the underlying molecular mechanisms.</div></div><div><h3>Methods</h3><div>Cell counting kit-8 assays, colony-forming assays, and flow cytometry for cell cycle and apoptosis assays were employed to determine the anti-tumor roles of CCPS. Liquid chromatography-mass spectrometry (LC-MS), network pharmacology, molecular docking, analysis of real-world clinical datasets of CRC, and western blotting were conducted to explore the molecular mechanism of CCPS on CRC. CRC xenografted mouse model, western blotting, and public CRC data analysis were conducted to evaluate the anti-tumor efficacy and mechanisms of CCPS on CRC.</div></div><div><h3>Results</h3><div>CCPS suppresses the growth of CRC cells and increases the number of apoptotic cells dose-dependently. CCPS targets and significantly downregulates RPA1 and enhances the phosphorylation of its downstream effectors, ATR and CHK1, which are critical for CRC progression. Additionally, CCPS shows a comparable anti-tumor effect in CRC xenografted mouse models compared to Capecitabine, a chemotherapy drug commonly used in clinics.</div></div><div><h3>Discussion</h3><div>Our findings demonstrate the potential use of CCPS in cancer treatment by suppressing cancer cell growth and modulating the RPA1/ATR/CHK1 signaling pathway in CRC. Further investigations on the application of CCPS in cancer therapies could be extended to evaluate the potential <em>in vivo</em> toxicity and adverse events, as well as the synergistic effect of CCPS in combination with other chemotherapeutic agents.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100524"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of inhibitory potential of the flavonoid-rich fraction of Myrica esculenta Buch.-Ham. ex D. Don against DSS-induced colonic inflammation in mice","authors":"Monika Joshi ,&nbsp;Manju Pandey ,&nbsp;Akash Ved","doi":"10.1016/j.prmcm.2024.100523","DOIUrl":"10.1016/j.prmcm.2024.100523","url":null,"abstract":"<div><h3>Objective</h3><div>Myrica esculenta (family Myricaceae), a valuable plant species in China and India, has been traditionally used by many tribes and local communities to manage gut disorders. Scientific validation of its anti-ulcerative colitis activity was aimed.</div></div><div><h3>Methods</h3><div>The ethyl acetate fraction of Myrica esculenta (MeEa) was prepared and evaluated for its potency against DSS-induced ulcerative colitis (UC) in mice at 200 and 400 mg/kg BW oral dose. The effective dose of MeEa was determined through its effect on DSS-induced UC and was further analyzed through its effects on disease activity index (DAI), colon length, colon weight/length ratio, spleen weight, serum and colon tissue cytokine level, cell count and hemoglobin content. Further, the effect was determined through histopathology and FITC-dextran-induced membrane permeability assay.</div></div><div><h3>Results</h3><div>Between the two doses, MeEa at 400 mg/kg BW was found to be the most effective dose in terms of reduced DAI scores, protected colon length from shortening, decreased colon weight/length ratio, reduced spleen weight, decreased pro-inflammatory cytokine level and stabilized the anti-inflammatory cytokine level in serum and colon tissue. MeEa 400 reduced cell counts and increased hemoglobin content and platelet count. MeEa 400 also prevented the colon by protecting epithelial cells and crypts. MeEa 400 provided significant protection from intestinal leakage and reduced FITC dextran level in serum.</div></div><div><h3>Discussion</h3><div>MeEa 400 possesses significant anti-inflammatory potential and acts via attenuation of DSS-induced UC and inhibition of DAI scores. It reduces pro-inflammatory cytokines and stabilizes anti-inflammatory cytokine levels, reduces cell count, and protects epithelial tissue and crypts in the colon, as well as intestinal membrane leakage that occurred due to FITC-dextran administration in mice.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100523"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the therapeutic potential of traditional Chinese medicine Rhizome Coptidis: A comprehensive review","authors":"Kuldeep Singh ,&nbsp;Jeetendra Kumar Gupta ,&nbsp;Divya Jain ,&nbsp;Alka N Chaudhary ,&nbsp;Shivendra Kumar ,&nbsp;Mukesh Chandra Sharma ,&nbsp;Bhupendra Singh","doi":"10.1016/j.prmcm.2024.100522","DOIUrl":"10.1016/j.prmcm.2024.100522","url":null,"abstract":"<div><h3>Introduction</h3><div><em>R. coptidis</em>, also known as Huang Lian in Chinese, has been a cornerstone of TCM for centuries. Its bitter and cold properties make it a versatile herb for treating various ailments. While traditionally used to clear heat, eliminate dampness, and alleviate toxicity, recent scientific investigations have revealed various pharmacological activities beyond its traditional applications.</div></div><div><h3>Methods</h3><div>A Comprehensive review of scientific databases, including PubMed, Web of Science, and Chinese medical literature databases, was conducted to gather comprehensive insights. The keywords used included \"<em>R. coptidis</em>,\" \"Huang Lian,\" \"pharmacological properties,\" \"therapeutic applications,\" and \"Traditional Chinese Medicine.\" Studies from both <em>in vitro</em> and <em>in vivo</em> experiments were considered, ensuring a well-rounded evaluation of the herb's effects.</div></div><div><h3>Results</h3><div>The pharmacological properties of <em>R. coptidis</em> are attributed to its main bioactive component, berberine. In various studies, Berberine has demonstrated antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Furthermore, its effects on metabolic disorders, cardiovascular health, and neuroprotection have sparked interest in its potential therapeutic applications.</div></div><div><h3>Discussion</h3><div>The diverse pharmacological effects of <em>R. coptidis</em> stem from its interactions with multiple molecular targets. Berberine's ability to modulate signaling pathways and gene expression has garnered attention as a promising candidate for drug development. However, challenges such as bioavailability and potential herb-drug interactions warrant further investigation.</div></div><div><h3>Conclusion</h3><div>In conclusion, <em>R. coptidis</em> holds immense promise as a therapeutic agent beyond its traditional uses in TCM. The rich pharmacological profile of berberine suggests its potential in addressing various health conditions. Nonetheless, rigorous clinical trials and translational research are necessary to bridge the gap between traditional wisdom and modern medical applications. As research continues, <em>R. coptidis</em> may emerge as a fundamental herb in TCM and contemporary medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100522"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis","authors":"Robin Raj ,&nbsp;Arpan Kumar Tripathi ,&nbsp;P. Saranya ,&nbsp;Jaskiran kaur ,&nbsp;Rashmi Saxena Pal ,&nbsp;Kuldeep Singh ,&nbsp;Divya Jain ,&nbsp;MVNL Chaitanya ,&nbsp;Shivendra Kumar","doi":"10.1016/j.prmcm.2024.100521","DOIUrl":"10.1016/j.prmcm.2024.100521","url":null,"abstract":"<div><h3>Introduction</h3><div>The escalating threat of drug-resistant tuberculosis (TB) necessitates urgent exploration of alternative treatment methods. Traditional Chinese medicinal (TCM) plants, rich in bioactive phytochemicals, present promising options for addressing this challenge. This review critically examines the molecular mechanisms underlying the therapeutic efficacy of phytochemicals derived from selected TCM against drug-resistant TB.</div></div><div><h3>Methods</h3><div>We searched Google Scholar, Scopus, PubMed, and Web of Science, among other search engines, to locate publications about natural compounds that may be utilised to treat multidrug-resistant tuberculosis (MDR TB). Studies from 2007 to 2023 were included, which addressed gaps in our current knowledge of tuberculosis (TB) and the potential of natural compounds. We employed various search terms such as \"Molecular targets and mechanisms,\" \"pathophysiology,\" \"nanotechnology,\" \"natural products,\" \"global statistics and multidrug-resistant TB,\" among others. We selected 108 of the 166 identified papers for evaluation. Only Traditional Chinese Medicinal Plant-Based Treatments for Multidrug-Resistant Tuberculosis were covered.</div></div><div><h3>Results</h3><div>Through an integrative analysis of recent research, we explored the multifaceted interactions between phytochemicals and various molecular targets within <em>Mycobacterium tuberculosis</em> (Mtb). We have highlighted prominent phytochemicals like curcumin from <em>Curcuma longa,</em> resveratrol from <em>Polygonum cuspidatum</em>, and berberine from Berberis spp., elucidating their mechanisms of action and potential synergistic effects with conventional anti-TB drugs. Additionally, we delved into the immunomodulatory properties of phytochemicals, emphasizing their ability to enhance host immune responses against TB infection.</div></div><div><h3>Discussion</h3><div>Innovative approaches such as network pharmacology and molecular docking (mannose receptor targets) are discussed for predicting and validating interactions between phytochemicals and Mtb targets. Moreover, we address challenges related to phytochemical bioavailability, pharmacokinetics, and formulation strategies, proposing methods to enhance their efficacy and clinical translation.</div></div><div><h3>Conclusion</h3><div>In conclusion, this review consolidating existing insights and identifying areas needing further research, this review offers a comprehensive framework for leveraging the therapeutic properties of phytochemicals from traditional medicinal plants, highlighting their potential as supplementary or alternative treatments for drug-resistant TB.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}