Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Emerging trends in pharmacological and therapeutic potential of glycyrrhizic acids: Traditional and nanotechnological approach","authors":"Priyanka Jurel,&nbsp;Shiv Bahadur,&nbsp;Meenakshi Bajpai","doi":"10.1016/j.prmcm.2024.100461","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100461","url":null,"abstract":"<div><h3>Introduction</h3><p>Glycyrrhizic acid which is the most important active ingredient extracted from the licorice root shows great potential as a carrier material in traditional chinese medicine. Nanotechnologies hold tremendous potential as an effective drug delivery system. Recent studies have indicated that the combination of glycyrrhizic acid and nanotechnology had better therapeutic effects.</p></div><div><h3>Materials and methods</h3><p>Literatures were searched from various databases such as PubMed, Web of Science, Scopus, Academic Journals Embase, Google Scholar and Science Direct by using keywords including like “Glycyrrhizic Acid” paired with “Traditional Chinese medicine”, “Pharmacological activities”, “Anti-tumor”, “Anti-viral”, “Hepatoprotective”, “Anti-psoriatic”, “Anti-Inflammatory”, “Nanotechnology”, or “Nanoemulsions” and their combinations, mainly from 2004 to 2024. According to the research reports, glycyrrhizic acid have a wide range of biological activities, containing anti-inflammatory, antiviral, antioxidant, gastro-protective effects, anti-obesity effects, nephroprotective effect, cardiovascular effects and hepatoprotective activity and so on.</p></div><div><h3>Results</h3><p>This article highlights the pharmacological properties of glycyrrhizic acid and its various potential therapeutic applications. The nanoformulation including polymeric nanoparticles, solid lipid nanoparticles, phytosomes, liposomes, nanofibers, nanoemulsions, and hydrogels, have been explored to enhance their therapeutic efficacy. These formulations may offer enhanced solubility and absorption, as well as controlled and sustained release of glycyrrhizic acid.</p></div><div><h3>Conclusions</h3><p>This review highlights on the recent studies for the pharmacological activities and therapeutic potential of glycyrrhizic acid, nanotechnology based drug delivery and major safety and toxicity issues glycyrrhizic acid also have been discussed.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100461"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001039/pdfft?md5=deb40b1a51bae2face3a77655a0afefb&pid=1-s2.0-S2667142524001039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daidzein in traditional Chinese medicine: A deep dive into its Ethnomedicinal and therapeutic applications","authors":"Neelam Singla ,&nbsp;Gaurav Gupta ,&nbsp;Rashi Kulshrestha ,&nbsp;Komal Sharma ,&nbsp;Asif Ahmad Bhat ,&nbsp;Riya Mishra ,&nbsp;Neeraj Patel ,&nbsp;Riya Thapa ,&nbsp;Haider Ali ,&nbsp;Anurag Mishra ,&nbsp;Rajesh Shukla ,&nbsp;Kumud Pant ,&nbsp;Saurabh Gupta","doi":"10.1016/j.prmcm.2024.100460","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100460","url":null,"abstract":"<div><h3>Introduction</h3><p>Daidzein, a secondary metabolite found in Soybean (Glycine max L.) and Pueraria lobata (Willd.), plays a pivotal role in various therapeutic applications, including its potential as an anticancer agent, particularly in estrogen-dependent breast cancer, along with anti-allergic, anti-inflammatory, cardiovascular, antidiabetic, antioxidative, and neurogenerative effects. Daidzein's ability to traverse the blood-brain barrier enhances cognition, reduces aggression, and promotes locomotor activity. Its structural resemblance to estrogens positions it as a potential remedy for menopausal osteoporosis.</p></div><div><h3>Methodology</h3><p>The methodology for the comprehensive review on Daidzein entailed a literature search utilising keywords such as \"Daidzein\" and various therapeutic activities, including “Antioxidant,” “Anti-inflammatory,” “Anticancer,” “Antiviral,” “Antiobesity,” “Antidiabetic,” “Nephrotoxicity,” “Cardiovascular,” “Neuroprotective,” “Osteoporosis,” “Menopausal Symptoms,” “Aging,” “Cognitive Activities”. Academic databases such as PubMed, Google Scholar, Scopus, and Web of Science were employed for the search, considering articles published within the last 20 years to capture recent research while encompassing significant historical studies.</p></div><div><h3>Results</h3><p>The results provide insights into the diverse effects of daidzein across various health domains, including its antioxidant, anti-inflammatory, anticancer, antiviral, antiobesity, antidiabetic, nephrotoxicity, cardiovascular, neuroprotective, osteoporosis, menopausal symptoms, ageing, and cognitive activities.</p></div><div><h3>Discussion</h3><p>: The discussion section critically analyses the collective evidence gathered from the studies. It explores the mechanisms underlying daidzein's therapeutic effects and discusses the implications of these findings for both Traditional Chinese Medicine and modern healthcare practices. However, challenges related to its low bioavailability and toxicity necessitate further research, providing a foundation for future studies on daidzein's potential applications.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100460"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001027/pdfft?md5=366b01986a412d6eb099f244810b30f2&pid=1-s2.0-S2667142524001027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Behavioral rescue: Naringenin's neuroprotective effects against PTZ-induced seizures by mitigating oxidative stress and neuroinflammation in zebrafish larvae\"","authors":"Ravikumar Manish,&nbsp;Durairaj Brindha,&nbsp;Uvarajan Deenathayalan","doi":"10.1016/j.prmcm.2024.100459","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100459","url":null,"abstract":"<div><h3>Introduction</h3><p>Epilepsy is a complex neurological disorder affecting approximately 70 million people worldwide, accounting for about 1 % of the global population. Despite significant advancements in pharmaceutical therapies, the molecular mechanisms underlying epileptogenesis remain poorly understood, leading to symptomatic treatment being ineffective for about 30 % of patients. Recent evidence implicates oxidative stress and neuroinflammation in the pathophysiology of epilepsy. Traditional Chinese Medicine (TCM) has been used for millennia across Asia and beyond to treat conditions such as cancer, cardiovascular disorders, and neurological diseases, owing to its proven effectiveness. Naringenin is a traditional Chinese component commonly found in citrus fruits and is a naturally occurring flavonoid.</p></div><div><h3>Methods</h3><p>The present investigation aimed to examine the neuroprotective properties of Naringenin in mitigating PTZ-induced seizures in zebrafish larvae. Zebrafish were administered Naringenin (50 µM) for 24 h at 6 days post-fertilization (dpf), followed by exposure to 15 mM PTZ for 30 min. The study assessed c-fos expression and synaptic activity, oxidative damage, antioxidant defence mechanisms, apoptosis, and levels of <em>nrf2, ho-1, and nqo-1</em> in the head regions of zebrafish larvae. Additionally, the expression of inflammatory cytokines (cox-2, <em>tnfα, il-1β,</em> and <em>il-6</em>) was evaluated.</p></div><div><h3>Results</h3><p>Naringenin pretreatment restored c-fos expression and synaptic activity in epileptic zebrafish larvae. The study observed high levels of oxidative damage, reduced antioxidant defences, and increased apoptosis in the larvae with epilepsy. Specifically, levels of <em>nrf2, ho-1, and nqo-1</em> were decreased in the head regions of the epileptic zebrafish larvae. Naringenin administration mitigated oxidative stress, reduced neuronal apoptosis, and increased the expression <em>of nrf2, ho-1, and nqo-1</em>. Additionally, during seizures, inflammatory cytokines such as <em>cox-2, tnfα, il-1β, and il-6</em> were upregulated, but naringenin pretreatment was shown to mitigate this effect.</p></div><div><h3>Discussion</h3><p>The findings collectively underscore the potential neuroprotective effects of Naringenin against PTZ-induced seizures. Naringenin modulates behavioural patterns, reduces oxidative stress, and dampens neuroinflammation, highlighting its promise as a therapeutic agent in epilepsy management. The comprehensive findings of this study serve as a foundation for further research into the mechanisms through which Naringenin confers its protective effects. Furthermore, it paves the way for exploring the potential clinical applications of Naringenin in treating epilepsy.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001015/pdfft?md5=29d2a4f12ab6f79e0d26be7fbc09ffc7&pid=1-s2.0-S2667142524001015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research of the mechanism of spatholobi caulis for immune-inflammatory of osteoarthritis based on clinical data mining,network pharmacology and cell experiment verification","authors":"Mingyu He,&nbsp;Jian Liu,&nbsp;Yanyan Fang,&nbsp;Yanqiu Sun,&nbsp;Fanfan Wang,&nbsp;Xu Li,&nbsp;Qi Han","doi":"10.1016/j.prmcm.2024.100454","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100454","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese medicine is widely used in the treatment of osteoarthritis. This study explores the therapeutic effect of Traditional Chinese Medicine (TCM) on osteoarthritis (OA), as well as the mechanism by which Spatholobi Caulis (SPC) improves the immune-Inflammatory response of OA.</p></div><div><h3>Methods</h3><p>The clinical data mining techniques to evaluate the efficacy of Caulis spatholobi in treating OA, and elucidated its mechanism of action using network pharmacology, molecular docking, and cell experiments. The random walk model was applied to systematically evaluate the therapeutic efficacy of Chinese herbal medicine on OA.</p></div><div><h3>Results</h3><p>The evaluation based on the clinical data mining showed that TCM is effective in improving ESR, CRP, C3, C4, and PLT. Data mining results showed significant OA treatment. Network analysis results showed that it may fight OA by targeting JUN, ESR1 and PPARG; molecular docking results showed good JUN, ESR1, PPARG and active component formononetin. Finally, <em>in vitro</em> experiments conducted the preliminary validation of formononetin for the core target of FLS. Cell proliferation was measured by CCK-8, and JUN, ESR1, PPARG protein, and mRNA expression was measured by quantitative real-time RCR at 48 h after drug intervention.</p></div><div><h3>Conclusion</h3><p>The present study demonstrated that the SPC effectively relieved immune inflammation indicators in OA patients. Formononetin, the main active component of the chicken blood vine, acts to reduce the immune validation response in OA patients by reducing the expression of ESR1, JUN, and PPARG.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100454"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000964/pdfft?md5=40abcd37c536fef0d2a7bbee0bf6a6e3&pid=1-s2.0-S2667142524000964-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical assessment, elemental composition, and biological kinetics of Foeniculum vulgare Mill. stalks","authors":"Covenant E. Ogbonna ,&nbsp;Doga Kavaz ,&nbsp;Yemi A. Adekunle ,&nbsp;David B. Olawade","doi":"10.1016/j.prmcm.2024.100453","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100453","url":null,"abstract":"<div><h3>Introduction</h3><p>The essential oil of <em>Foeniculum vulgare</em> (Fennel) has been extensively studied for phytochemical and elemental compositions, biochemical significance, and biological activities. However, the literature has a dearth of information on the Fennel stalk as a potential source of antioxidant and antibacterial agents. This study aimed to evaluate the phytochemical and elemental composition of Fennel stalks and also, to investigate the kinetic DPPH scavenging property and antibacterial activity of Fennel stalk extracts.</p></div><div><h3>Methods</h3><p>Fennel aqueous extract (FVAE) was prepared by mixing of powdered fennel stalks with sterile distilled water, followed by heating and filtration. Methanol (FVME) and ethanol (FVEE) extracts of <em>F. vulgare</em> were prepared by macerating the stalk with respective solvents, followed by filtration. Gas chromatography-mass spectrometry (GC–MS) analysis, Fourier Transform Infrared Spectroscopy (FTIR), determination of total phenols, and X-ray fluorescence were conducted to analyze the chemical composition of the extracts. Biological activities, including DPPH scavenging and antimicrobial activity against Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and <em>Escherichia coli</em>, were evaluated through spectrophotometric methods and well diffusion assay, respectively.</p></div><div><h3>Results</h3><p>The GCMS analysis revealed 15 compounds including anozol, myristyl iodine, flexiricin, dutadrupine, cycloheptaciloxane, neophytadiene, phthalic acid, and ribitol. Some of these compounds have not been reported from this plant before. FTIR analysis suggested hydroxyl (OH), alkane (CH), carbonyl (C = O), aromatic (C = C), and ether (CO) functional groups in the Fennel extracts. X-ray fluorescence identified elements including titanium, chromium, manganese, iron, nickel, copper, zinc, rubidium, and strontium. The ethanol extract had higher total phenolic content (72.45±0.01 mg GAE/g) than the aqueous (54.3 ± 0.01 mg GAE/g) and methanol (51.3 ± 0.01 mg GAE/g) extracts. In addition, a high% DPPH scavenging activity was observed in the ethanol extract (85.1 %) compared to that of ascorbic acid (96.2 %). Fennel's stalks methanol extract showed significant inhibition against the growth of <em>E. coli</em> 0157 and Methicillin-resistant <em>Staphylococcus aureus</em> B-4420, having zones of inhibition diameters of 16 mm and 13 mm, respectively. This is similar to what was observed for chloramphenicol and azithromycin.</p></div><div><h3>Conclusion</h3><p>The current study has demonstrated that Fennel stalks contain potentially useful antioxidant and antibacterial properties, in addition to the well-studied essential oil of its fruits and seeds.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100453"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000952/pdfft?md5=5ffbffdbeae988318e2cbbe7127edbfd&pid=1-s2.0-S2667142524000952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review","authors":"Kuldeep Singh ,&nbsp;Jeetendra Kumar Gupta ,&nbsp;Divya Jain ,&nbsp;Shivendra Kumar ,&nbsp;Talever Singh ,&nbsp;Sunam Saha","doi":"10.1016/j.prmcm.2024.100448","DOIUrl":"10.1016/j.prmcm.2024.100448","url":null,"abstract":"<div><h3>Introduction</h3><p>Chinese medicine, rooted in a rich history dating back thousands of years, offers a holistic approach to healthcare that has endured the test of time. This comprehensive review explores the ancient wisdom and modern relevance of Chinese medicine, shedding light on its principles, practices, and adaptability in contemporary healthcare.</p></div><div><h3>Methods</h3><p>This review employs a multidisciplinary approach, drawing upon ancient texts, modern scientific research, and clinical studies to elucidate the core tenets of Chinese medicine. A comprehensive literature search was conducted in various databases, including PubMed, Web of Science, and traditional Chinese medical databases, to identify relevant articles, books, and historical documents.</p></div><div><h3>Results</h3><p>The review synthesizes the fundamental concepts of Chinese medicine, such as Qi, Yin-Yang, the five elements, and meridian system, while examining their physiological and clinical significance in the context of modern medicine. It also delves into the integration of Chinese Medicine into mainstream healthcare systems worldwide, highlighting its growing acceptance and utilization in the treatment of various conditions, including chronic pain, mental health disorders, and complementary cancer care.</p></div><div><h3>Discussion</h3><p>The discussion section explores the synergy between traditional Chinese medicine and contemporary medical practices, emphasizing the potential for a complementary approach that bridges the gap between Eastern and Western healthcare. It addresses the challenges and opportunities in integrating Chinese medicine into evidence-based medicine, emphasizing the importance of rigorous research and standardization.</p></div><div><h3>Conclusion</h3><p>In conclusion, this review underscores the enduring wisdom of Chinese medicine, showcasing its adaptability and relevance in the modern healthcare landscape. It advocates for continued collaboration between traditional Chinese medicine and conventional medical systems, fostering a more holistic and patient-centered approach to healthcare. By embracing the ancient wisdom of Chinese medicine alongside modern medical advancements, we can pave the way for a healthier and more balanced future.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100448"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000903/pdfft?md5=e48f46d486591d33ab18609fadd731ef&pid=1-s2.0-S2667142524000903-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141140120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the miRNAs-regulated mechanisms by which natural plant polysaccharides control apoptosis","authors":"Chong Wang ,&nbsp;Xueqin Duan ,&nbsp;Huicong Li ,&nbsp;Siyu Zeng ,&nbsp;Yang Yang ,&nbsp;Weimin Zhang ,&nbsp;Yingqiu Liu ,&nbsp;Wuren Ma ,&nbsp;Lin Ma ,&nbsp;Yunpeng Fan","doi":"10.1016/j.prmcm.2024.100456","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100456","url":null,"abstract":"<div><h3>Instruction</h3><p>Plant polysaccharides are important components of Chinese herbal medicine. Many polysaccharides, such as <em>Astragalus</em> polysaccharide and <em>Lycium barbarum</em> polysaccharide, have important functions such as tumor growth inhibition, antioxidant, anti-aging and immune regulation.</p></div><div><h3>Methods</h3><p>Literature searches were conducted on the following databases: Pubmed, ACS website, Elsevier, Google Scholar, Web of Science and CNKI database. Keywords such as “plant polysaccharides”, “apoptosis”, “miRNA”, “apoptosis pathway” and “regulation of apoptosis” were used to search relevant journals and contents, and some irrelevant contents were excluded. In this review, the effects of plant polysaccharides on cell apoptosis and how to regulate miRNA expression were reviewed, which provided the basis for further research on the mechanism of polysaccharide action.</p></div><div><h3>Results</h3><p>Plant polysaccharides regulated apoptosis probably by regulating the expression of mirnas, and the expression of certain downstream signaling factors of miRNA were changed. Some of these factors could directly act on apoptosis-related signals, activate or inhibit signaling pathways, and thus regulate cell apoptosis.</p></div><div><h3>Discussion and conclusion</h3><p>In this review, we discussed the regulatory effects of plant polysaccharides on apoptosis and their possible molecular mechanisms. However, most of the current studies lack clinical experimental data, so it is still necessary to further study the specific mechanism of plant polysaccharides affecting cell miRNA expression and apoptosis, so that plant polysaccharides can be more widely used in clinical and practical aspects.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100456"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000988/pdfft?md5=c556a37bd7508e88ec275788917375e1&pid=1-s2.0-S2667142524000988-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of Madhuca longifolia in traditional Chinese medicine for the management of kidney stones and various diseases: A review","authors":"Dilip Kumar Chanchal,&nbsp;Satish Kumar Sharma","doi":"10.1016/j.prmcm.2024.100452","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100452","url":null,"abstract":"<div><h3>Introduction</h3><p>Kidney stones (renal calculi), are a common urological problem affecting millions worldwide. <em>Madhuca longifolia</em> (<em>M. longifolia</em>), commonly known as Mahua, has a rich history of medicinal use in various traditional systems, including Traditional Chinese Medicine (TCM). This review aims to explore the therapeutic potential of <em>M. longifolia</em> in the management of kidney stones through the lens of TCM.</p></div><div><h3>Methods</h3><p>Examination of the therapeutic efficacy of <em>M. longifolia</em> in the context of TCM for the treatment of kidney stones was undertaken by performing an exhaustive literature review via internet-based databases, such as PubMed, Scopus, and Google Scholar. Keywords such as \"<em>Madhuca longifolia</em>,\" \"Mahua,\" \"kidney stones,\" \"renal calculi,\" \"Pharmacological activity,\" and \"Traditional Chinese Medicine\" were used to ensure the inclusivity of relevant literature. Studies published between 1972 and 2019 were considered. Inclusion criteria were peer-reviewed articles, systematic reviews, focusing on the health impacts of plant-based diets. Information on the subspecies and cultivars of common names and the scientific names was verified using the Plant List (www.theplantlist.org) database. We retrieved and utilised it for the review of 80 articles.</p></div><div><h3>Results</h3><p>The literature review revealed several studies highlighting the potential therapeutic effects of <em>M. longifolia</em> in the management of kidney stones. The bioactive compounds present in <em>M. longifolia</em>, including flavonoids, phenolic compounds, and saponins, exhibit diuretic, anti-inflammatory, and litholytic properties, which contribute to the dissolution and prevention of kidney stones. Furthermore, <em>Madhuca longifolia</em> demonstrates various pharmacognostic activities, reducing the risk of renal damage associated with kidney stone formation.</p></div><div><h3>Discussion</h3><p>Traditional Chinese Medicine recognizes <em>M. longifolia</em> as a valuable botanical resource for the medical management of kidney calculi. It presents a natural and comprehensive strategy for managing the intricacies associated with kidney stones.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100452"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000940/pdfft?md5=4b2dcd586836bec8e6befc9216b211f5&pid=1-s2.0-S2667142524000940-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety of 16 Chinese patent medicines in combination with benzodiazepines/non-benzodiazepines for the treatment of chronic insomnia in adults: A multiple-treatment meta-analysis","authors":"Ciyan Peng ,&nbsp;Jing Chen ,&nbsp;Sini Li ,&nbsp;Boyin Huang ,&nbsp;Wei Cui ,&nbsp;Jianhe Li ,&nbsp;Liubao Peng","doi":"10.1016/j.prmcm.2024.100449","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100449","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic insomnia in adults affects the health and quality of life of patients. Chinese patent medicines (CPMs) combined with benzodiazepines/non-benzodiazepines (BZDs/N-BZDs) are used frequently in routine clinical practice. However, evidence on the efficacy and safety of these combined interventions is lacking. A multiple treatment meta-analysis (MTMA) was conducted to evaluate the comparative efficacy and safety of 16 CPMs combined with BZDs/N-BZDs for the treatment of chronic insomnia in adults.</p></div><div><h3>Methodology</h3><p>We systematically reviewed 171 randomized controlled trials (RCTs) involving 16,874 participants (8506 in intervention groups and 8368 in control groups) from the inception of several databases to 2023. This review encompassed electronic databases, regulatory-agency websites, and international registers of published trials involving adult patients with chronic insomnia who received CPM + BZDs/N-BZDs therapies. A random-effects MTMA was undertaken using Stata/MP17, RevMan (5.3), and R. Outcome measures were the Pittsburgh Sleep Quality Index (PSQI), overall efficacy rate, as well as the incidence of dry mouth, dizziness, and somnolence.</p></div><div><h3>Results</h3><p>Our MTMA showed that BZD/N-BZD therapy as a co-intervention for Tianmengjiaonang (TMJN) was likely to be the optimal option for improving the PSQI (surface under the cumulative sorting curve (SUCRA) = 95.00 %), whereas shensongyangxinjiaonang (SSYXJN) had the highest probability of improving overall effectiveness (SUCRA = 88.20 %). Jiaotaiwan (JTW), Bailemian (BLMJN), and Wulinjiaonang (WLJN) had the highest probability of reducing the incidence of somnolence (SUCRA = 90.00 %), dry mouth (SUCRA = 72.90 %), and dizziness (SUCRA = 84.40 %).</p></div><div><h3>Conclusions</h3><p>All CPMs in combination with BZDs/N-BZDs were more efficacious and safer than using BZDs/N-BZDs alone in adults with chronic insomnia. SSYXJN + BZDs/N-BZDs and TMJN + BZDs/N-BZDs are likely to be optimal CPMs because they improve overall efficacy and sleep quality and reduce the risk of adverse effects. However, the effects of these interventions may vary from person to person. Hence, patients, carers, and clinicians should carefully consider the efficacy, safety, and risk–benefit profile of all active interventions for patients with insomnia based on real-world data.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100449"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000915/pdfft?md5=e38344e0c94ae4d145c73273952c7038&pid=1-s2.0-S2667142524000915-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational investigation of Y. aloifolia variegate as anti-Human Immunodeficiency Virus (HIV) targeting HIV-1 protease: A multiscale in-silico exploration","authors":"Riyan Alifbi Putera Irsal ,&nbsp;Gusnia Meilin Gholam ,&nbsp;Maheswari Alfira Dwicesaria ,&nbsp;Fernanda Chairunisa","doi":"10.1016/j.prmcm.2024.100451","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100451","url":null,"abstract":"<div><h3>Introduction</h3><p>Human Immunodeficiency Virus (HIV) is a global challenge for the health sector due to the absence of a definitive cure. More than 38 million people are affected by the disease worldwide, with approximately 1.5 million new cases reported annually. This situation has spurred continued efforts in searching for drug candidates. Meanwhile, rutin, luteolin, and quercetin are compounds known for efficacy in treating infectious diseases. The compounds have also been detected in <em>Yucca aloifolia</em> (絲蘭) variegate L. Therefore, this study aimed to conduct a computational investigation utilizing multiscale <em>in silico</em> exploration to assess the potential of <em>Y. aloifolia</em> as an anti-HIV agent targeting HIV-1 Protease (H1P).</p></div><div><h3>Methods</h3><p>For the <em>in silico</em> study, the three-dimensional structure of H1P (PDB: 5V4Y) was retrieved and prepared using YASARA Structure. The binding pockets were identified using Cavity Plus server, and ligands were obtained from <em>Y. aloifolia</em> leaves alcohol extract. Furthermore, molecular docking was conducted with YASARA Structure to predict binding energies, followed by QSAR analysis for activity prediction. Density Functional Theory (DFT) analysis was performed to assess stability and reactivity, while toxicity was evaluated using ProTox 3.0. Molecular dynamics (MD) simulation and Molecular Mechanics Poisson–Boltzmann Surface Area (MM-PBSA) calculation were also conducted for further analysis.</p></div><div><h3>Results</h3><p>The results showed that Ramachandran plot analysis indicated favorable residue distribution based on the evaluation of enzyme preparation quality. Cavity Plus identified potential binding sites, with cavity no.2 showing the highest druggability. Molecular docking showed rutin and isorhamnetin-3-<em>O</em>-rutinoside as top binders to H1P, with favorable binding energies. Moreover, post-docking analysis produced specific interactions between ligands and the receptor. PASS prediction indicated the potential of rutin and isorhamnetin-3-<em>O</em>-rutinoside (narcissin) as H1P inhibitors. DFT analysis assessed stability, showing comparable values for the investigated compounds. Toxicity analysis suggested both compounds to be non-toxic. Finally, MD simulation demonstrated the superior stability and binding affinity of rutin compared to isorhamnetin-3-<em>O</em>-rutinoside and the control drug, grl-09510.</p></div><div><h3>Discussion</h3><p>Rutin, hecogenin, and isorhamnetin-3-<em>O</em>-rutinoside from <em>Y. aloifolia</em> (絲蘭) leaves showed potential as H1P inhibitors through <em>in silico</em> study. Docking simulations indicated that rutin had the most favorable binding interactions, while MD simulation showed only the rutin-H1P complex to be stable, signifying the potential for further drug development. Rutin was identified as a promising lead for H1P inhibition due to its strong binding, stability, and predicted safety prope","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100451"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000939/pdfft?md5=11f313250fc19dedeb0cfafe0ceb9846&pid=1-s2.0-S2667142524000939-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}