Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis","authors":"Robin Raj ,&nbsp;Arpan Kumar Tripathi ,&nbsp;P. Saranya ,&nbsp;Jaskiran kaur ,&nbsp;Rashmi Saxena Pal ,&nbsp;Kuldeep Singh ,&nbsp;Divya Jain ,&nbsp;MVNL Chaitanya ,&nbsp;Shivendra Kumar","doi":"10.1016/j.prmcm.2024.100521","DOIUrl":"10.1016/j.prmcm.2024.100521","url":null,"abstract":"<div><h3>Introduction</h3><div>The escalating threat of drug-resistant tuberculosis (TB) necessitates urgent exploration of alternative treatment methods. Traditional Chinese medicinal (TCM) plants, rich in bioactive phytochemicals, present promising options for addressing this challenge. This review critically examines the molecular mechanisms underlying the therapeutic efficacy of phytochemicals derived from selected TCM against drug-resistant TB.</div></div><div><h3>Methods</h3><div>We searched Google Scholar, Scopus, PubMed, and Web of Science, among other search engines, to locate publications about natural compounds that may be utilised to treat multidrug-resistant tuberculosis (MDR TB). Studies from 2007 to 2023 were included, which addressed gaps in our current knowledge of tuberculosis (TB) and the potential of natural compounds. We employed various search terms such as \"Molecular targets and mechanisms,\" \"pathophysiology,\" \"nanotechnology,\" \"natural products,\" \"global statistics and multidrug-resistant TB,\" among others. We selected 108 of the 166 identified papers for evaluation. Only Traditional Chinese Medicinal Plant-Based Treatments for Multidrug-Resistant Tuberculosis were covered.</div></div><div><h3>Results</h3><div>Through an integrative analysis of recent research, we explored the multifaceted interactions between phytochemicals and various molecular targets within <em>Mycobacterium tuberculosis</em> (Mtb). We have highlighted prominent phytochemicals like curcumin from <em>Curcuma longa,</em> resveratrol from <em>Polygonum cuspidatum</em>, and berberine from Berberis spp., elucidating their mechanisms of action and potential synergistic effects with conventional anti-TB drugs. Additionally, we delved into the immunomodulatory properties of phytochemicals, emphasizing their ability to enhance host immune responses against TB infection.</div></div><div><h3>Discussion</h3><div>Innovative approaches such as network pharmacology and molecular docking (mannose receptor targets) are discussed for predicting and validating interactions between phytochemicals and Mtb targets. Moreover, we address challenges related to phytochemical bioavailability, pharmacokinetics, and formulation strategies, proposing methods to enhance their efficacy and clinical translation.</div></div><div><h3>Conclusion</h3><div>In conclusion, this review consolidating existing insights and identifying areas needing further research, this review offers a comprehensive framework for leveraging the therapeutic properties of phytochemicals from traditional medicinal plants, highlighting their potential as supplementary or alternative treatments for drug-resistant TB.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Hehuan Anshen decoction inhibits ferroptosis to ameliorate p-Chlorophenylalanine-induced insomnia by activating GPX4 pathway [Pharmacological Research-Modern Chinese Medicine volume 13 (2024) 100504]","authors":"Qing Deng ,&nbsp;Yanan Li ,&nbsp;Wenyun Kui ,&nbsp;Linting He ,&nbsp;Yuxia Wang ,&nbsp;Nana Li ,&nbsp;Jian Xu ,&nbsp;Kaiqiang Wang ,&nbsp;Chunchun Xue ,&nbsp;Zhongwei Sha","doi":"10.1016/j.prmcm.2024.100519","DOIUrl":"10.1016/j.prmcm.2024.100519","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100519"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological properties of Humulus scandens: Insights from the TCMSP database and existing understanding","authors":"De Xin Dang ,&nbsp;Desheng Li ,&nbsp;Shi Qi Xu ,&nbsp;Feng He ,&nbsp;Xinhua Xia ,&nbsp;Shaoyong Xu","doi":"10.1016/j.prmcm.2024.100518","DOIUrl":"10.1016/j.prmcm.2024.100518","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Humulus scandens</em> (HS) has been traditionally used in folk medicine for treating a wide spectrum of ailments. Despite its long history of use, its integration into modern medicine has been relatively limited. This review aims to summarize the existing understanding of the pharmacological effects of HS and explore its potential pharmacological benefits using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database.</div></div><div><h3>Methods</h3><div>we reviewed the pharmacological effects of HS by conducting a thorough literature search across databases like Google Scholar, CNKI, RISS, and J-Stage, as well as searching classical sources such as “Ben Cao Gang Mu” and “Ming Yi Bie Lu”. Furthermore, we used the TCMSP database to identify bioactive components of HS, focusing on those with oral bioavailability ≥ 30 % and drug-likeness ≥ 0.18, and explored the potential diseases associated with these components.</div></div><div><h3>Results</h3><div>HS as a traditional herbal medicine has been used to treat congestion, hematuria, strangury, watery diarrhea, and sores, as well as to enhance kidney function and promote urination. It has also served as a remedy for snake and scorpion bites. Modern experimental evidence suggests that HS exhibits efficacy in treating a wide range of conditions, including inflammation, and disorders of the respiratory system, urinary system, skin, gastrointestinal tract, nervous system, and cardiocerebral vascular system, as well as immunity-related diseases. Furthermore, it demonstrates promising properties in anti-cancer activity, hepatoprotection, lipid metabolism regulation, pain relief, alleviating diarrhea, and treating mental illness. Beyond these known effects, evidence from the TCMSP database highlights its potential in treating tumors, eye disorders, muscle disorders, diabetes, insomnia, and developmental disabilities.</div></div><div><h3>Discussion</h3><div>HS is a traditional herbal medicine with multiple pharmacological properties. However, while some pharmacological properties of HS have been validated through experiments, further research efforts are needed to explore its other effects. Such endeavors are crucial for a thorough understanding of HS and its potential therapeutic application.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100518"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Wild Chaga (Inonotus obliquus) modulates inflammation, neural cell survival and inhibits proliferation of cancer cells” [Pharmacological Research - Modern Chinese Medicine 9C (2023) /100328]","authors":"Susan SC Cheung ,&nbsp;Garyen Chong ,&nbsp;Ingrid Elisia ,&nbsp;David Hasman ,&nbsp;Martin Lee ,&nbsp;Linda Chang ,&nbsp;Ziliang Ao ,&nbsp;Djamel Khelifi ,&nbsp;Gerald Krystal ,&nbsp;Joseph Tai","doi":"10.1016/j.prmcm.2024.100515","DOIUrl":"10.1016/j.prmcm.2024.100515","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100515"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266714252400157X/pdfft?md5=3473fd105a21110d4dfd7501ee31da52&pid=1-s2.0-S266714252400157X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Syringic acid ameliorates testicular oxidative stress via the conservation of endogenous antioxidant markers and inhibition of the activated Nrf2-Keap1-NQO1-HO1 signaling in methyl cellosolve-administered rats” [Pharmacological Research - Modern Chinese Medicine 6C (2023) /100207]","authors":"Oluwatobi T. Somade ,&nbsp;Basiru O. Ajiboye ,&nbsp;Olukemi A. Osukoya ,&nbsp;Theophilus A. Jarikre ,&nbsp;Babatunji E. Oyinloye","doi":"10.1016/j.prmcm.2024.100513","DOIUrl":"10.1016/j.prmcm.2024.100513","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100513"},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001556/pdfft?md5=82f9a3266a2c0ae7e5f1d98029845fe6&pid=1-s2.0-S2667142524001556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Clinical efficacy and safety of Xuanfei Touxie Fang as a complementary medicine in the treatment of SARS-CoV-2 Omicron variant: A retrospective study” [Pharmacological Research - Modern Chinese Medicine 11C (2024) /100434]","authors":"Qingyuan Zhu,&nbsp;Baizhu Chen,&nbsp;Huixi Tong,&nbsp;Xiangyu Xu,&nbsp;Dongxiao Yang,&nbsp;Shuiyou Wang","doi":"10.1016/j.prmcm.2024.100516","DOIUrl":"10.1016/j.prmcm.2024.100516","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100516"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001581/pdfft?md5=7983fa3dc547ee9998f34d757e636c35&pid=1-s2.0-S2667142524001581-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Drosophila model and network pharmacology to explore novel targets and novel active components of chinese traditional medications for treating kidney stones” [Pharmacological Research - Modern Chinese Medicine 6C (2023) /100220]","authors":"Shiyu Zhang ,&nbsp;Jingnan Zhu ,&nbsp;Yingjie Ju ,&nbsp;Mingxia Lv ,&nbsp;Rongdian Yang ,&nbsp;Ying Li ,&nbsp;Yaodong Miao ,&nbsp;Yiwen Wang","doi":"10.1016/j.prmcm.2024.100517","DOIUrl":"10.1016/j.prmcm.2024.100517","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100517"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001593/pdfft?md5=d74da3e4564f073f5c8bdedfbf04e68b&pid=1-s2.0-S2667142524001593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory activity and molecular docking studies of the hydromethanolic leaf extract of Baphia longipedicellata brumitt in rats","authors":"Farouk Adedeji Oladoja ,&nbsp;Olufunsho Awodele ,&nbsp;Ibrahim A. Oreagba ,&nbsp;Emmanuel S. Irokosu ,&nbsp;Elijah O. Oyinloye ,&nbsp;Akanji A. Murtala","doi":"10.1016/j.prmcm.2024.100512","DOIUrl":"10.1016/j.prmcm.2024.100512","url":null,"abstract":"<div><div><strong>Background</strong>: Almost all Baphia species of the Fabaceae family have a long history in traditional China due to their potent anti-inflammatory properties <em>Baphia longipedicellata</em> (<em>B. longipedicellata</em>) is a relatively novel plant comprised mainly of stigmasterol, which has a rich history in Chinese medicine and is a principal active component in numerous Chinese herbs such as <em>maidong</em>, the <em>banxia-baizhu-tianma decoction</em> and <em>Qingfengteng</em> which are all native to China and well known for its use in inflammatory diseases, asthma and diabetes management.</div><div><strong>Aim of the study:</strong> The study was meticulously designed to evaluate the anti-inflammatory activity of <em>Baphia longipedicellata</em> in rats. What sets this study apart is its unique approach to predicting the mechanism of anti-inflammatory action through docking studies.</div><div><strong>Materials and Methods:</strong> Preliminary phytochemical screening and oral acute toxicity were carried out for the hydromethanolic extract of <em>Baphia longipedicellata</em> (HMBL). Phytocompounds in the extract were identified using high-performance Liquid Chromatography (HPLC). Carrageenan and egg albumin-induced paw edema models in rats were evaluated to ascertain the extract's anti-inflammatory potential.</div><div>Molecular docking experiments were carried out to evaluate the binding affinity of HPLC-selected compounds to cyclooxygenase-2 (COX-2) and tumour necrosis Factor-alpha (TNF-alpha).</div><div><strong>Results and Discussion:</strong> Preliminary phytochemical screening revealed the presence of saponin, tannins, cardiac glycosides, alkaloids, terpenoids, etc. Results obtained from this study showed that the LD50 was greater than 2000 mg/kg, and there were no observable toxic effects or mortality following its acute exposure.</div><div>HPLC of HMBL profiled, Curcumin, Lutein, Stigmasterol, Beta-Sitosterol, Chrysarobin, Quercetin, and Napabucasin,</div><div>HMBL extract at all treatment doses showed a significant reduction in both carrageenan and egg albumin-induced hind paw edema in a dose-dependent manner, comparable to the standard drug Diclofenac. Peak anti-oedematogenic activity was observed at the 6th-hour post-carrageenan injection with 28.50, 42.06, and 36.90 % inhibition for HMBL (100, 200, or 400 mg/kg) and 5th-hour post-egg-albumin injection with 61.22, 66.88, and 48.06 % inhibition.</div><div>The molecular docking study showed that all the isolated HPLC compounds inhibited COX-2 and TNF-alpha.</div><div><strong>Conclusion</strong> Ultimately, the hydro-methanolic leaf extract of <em>B. longipedicellata</em> exhibits potent anti-inflammatory activity via COX 2 and TNF-alpha inhibition. Thus, it would be a viable phytotherapeutic option for treating inflammatory conditions.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100512"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological effects of Berberine – A Chinese medicine, against xenobiotics toxicity","authors":"Annu Phogat,&nbsp;Jagjeet Singh,&nbsp;Vinay Malik","doi":"10.1016/j.prmcm.2024.100507","DOIUrl":"10.1016/j.prmcm.2024.100507","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine has used plant-derived natural antioxidants from herbs since ages. Berberine is an iso-quinoline-based alkaloid found in various medicinal herbs: <em>Coptis chinensis (Huanglian), Phellodendron amurense (Huangbai</em>) and used in traditional Chinese medicine as decoctions: ‘<em>Xie Xin</em>’ and ‘<em>Huanglian Jiedu</em>’. It has been used since long to treat inflammation, auto-immune diseases and dysentery. Studies have also confirmed its antioxidative, anti-inflammatory, anti-apoptotic, and pharmacological properties. Still, there is a gap between the preclinical significance and clinical efficacy of Berberine against organ toxicity. Thus, the present review summarises the ameliorative potential of Berberine against free radicals-mediated oxidative stress, cholinergic stress, inflammation, mitochondrial dysfunctions, and apoptosis.</div></div><div><h3>Methods</h3><div>Various scientific research articles in Google Scholar, PubMed, Scopus, Web of Science, and ScienceDirect, were explored to find the pharmacological effects of Berberine. More than 80 articles since 2010 were explored among which 40 were shortlisted with the keywords: Berberine followed by ‘mechanism,’ ‘ameliorative properties,’ ‘pharmacological properties,’ ‘antioxidant; Berberine against ‘pesticide toxicity’, ‘heavy metal toxicity’ ‘nephrotoxicity’ ‘hepatotoxicity’ ‘neurotoxicity’. The thus selected research articles were carefully read to summarise the latest and most recent developments in writing of this review.</div></div><div><h3>Results</h3><div>The structural and functional diversity of Berberine is responsible for the protective efficacy against organ toxicity. The molecular mechanism of Berberine suggests attenuation of oxidative stress, regulation of endogenous antioxidants, and activation of signaling pathways, including PPARɣ/PGC-1α, HNF4α/MTTP, PTEN/Akt, Nrf-2/HO-1/MnSOD, and SIRT1/P66Shc along with inhibition of NF-κB translocation; can ameliorate organ dysfunctioning.</div></div><div><h3>Discussion</h3><div>The current review summarises a baseline and preclinical evidence comprising their mechanistic bases, highlighting the ethnopharmacological applications of Berberine for both traditional Chinese medicine and modern therapeutics. This evaluation will give the crucial insight essential for toxicological and pharmacokinetic research on human models to verify the safety issues and confirm the effects of active components of Berberine in the body in a clinical context.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100507"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001490/pdfft?md5=cceb8eedb132a15c4a47e76fb0bba748&pid=1-s2.0-S2667142524001490-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma Oryzanol: A natural compound with potential for treating polycystic ovary syndrome","authors":"Sayantika Chakraborty,&nbsp;Navneet Khurana,&nbsp;Jaskiran Kaur,&nbsp;Meenu Mehta,&nbsp;Neha Sharma","doi":"10.1016/j.prmcm.2024.100506","DOIUrl":"10.1016/j.prmcm.2024.100506","url":null,"abstract":"<div><h3>Introduction</h3><p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Current management strategies only provide symptomatic relief, and there is a need for better treatments. Gamma-oryzanol, a dietary component found in rice bran oil, has been shown to be effective in increasing insulin sensitivity, reducing weight, and alleviating oxidative stress. In modern Chinese medicine, 香格里拉谷维素胶囊, 纯净谷维素软胶囊, and 诺特博谷维素片 are some of the medicines marketed in China that contain gamma-oryzanol. This study aims to evaluate the effects of gamma-oryzanol on clinical hallmarks of PCOS. Also to compare the efficacy of gamma-oryzanol alone versus in combination with clomifene citrate.</p></div><div><h3>Methods</h3><p>In this study, PCOS was induced in a rat model using estradiol valerate. Gamma-oryzanol was then administered both alone and in combination with clomifene citrate.</p></div><div><h3>Results</h3><p>The effects of gamma-oryzanol on estrous cyclicity, fertility, histopathological alterations, estradiol and testosterone levels, and oxidative parameters were evaluated. The results showed that gamma-oryzanol, both alone and in combination with clomifene citrate, had protective effects against the estradiol valerate-induced PCOS rat model. The combination of gamma-oryzanol and clomifene citrate was particularly effective, showing significantly better results than the standard treatment group (clomifene citrate alone).</p></div><div><h3>Discussion</h3><p>These results suggest that gamma-oryzanol could be used in combination with existing standard treatments to enhance the management of PCOS. However, further molecular and clinical studies are needed to confirm these findings.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"13 ","pages":"Article 100506"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001489/pdfft?md5=5f6bcca05a354f4ecd74b244470761fd&pid=1-s2.0-S2667142524001489-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}