Nano TransMed最新文献_第2页

Plant-based nanotherapeutics: A new frontier in disease management and prevention 植物纳米疗法：疾病管理和预防的新前沿

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-05-08 DOI: 10.1016/j.ntm.2025.100086

Sumitha Elayaperumal , Yuvaraj Sivamani , Parth Agarwal , Nimmy Srivastava

{"title":"Plant-based nanotherapeutics: A new frontier in disease management and prevention","authors":"Sumitha Elayaperumal , Yuvaraj Sivamani , Parth Agarwal , Nimmy Srivastava","doi":"10.1016/j.ntm.2025.100086","DOIUrl":"10.1016/j.ntm.2025.100086","url":null,"abstract":"<div><div>Nanotechnology has emerged as a transformative force in the field of medicine, offering innovative solutions for the diagnosis, treatment, and prevention of diseases. Among the myriad sources of nanomaterials, plant-based nanotherapeutics stand out due to their biocompatibility, eco-friendliness, and potential for sustainable production. These nanomaterials show promise across a range of diseases, demonstrating significant anticancer activity and potent antimicrobial properties against bacterial, viral, and fungal infections. Additionally, their applications in managing diabetes, reducing inflammation, and promoting wound healing highlight their versatility and effectiveness. Despite challenges such as scaling up nanoparticle production, ensuring stability, and creating standardized regulatory frameworks, the future of plant-based nanotherapeutics is promising. As the field advances, plant-based nanotherapeutics have the potential to transform healthcare by providing more effective, safe, and eco-friendly treatment options. This review article delves into the burgeoning field of plant-based nanotherapeutics, highlighting their mechanisms of action, and diverse applications in disease treatment.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anticancer, antioxidant, and antimicrobial properties of zinc oxide nanoparticles: A comprehensive review 氧化锌纳米颗粒的抗癌、抗氧化和抗菌性能：综合综述

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-09-09 DOI: 10.1016/j.ntm.2025.100097

Aeshah M. Mohammed , Mohammed Mohammed , Jawad K. Oleiwi , Falah H. Ihmedee , Tijjani Adam , Bashir O. Betar , Subash C.B. Gopinath

{"title":"The anticancer, antioxidant, and antimicrobial properties of zinc oxide nanoparticles: A comprehensive review","authors":"Aeshah M. Mohammed , Mohammed Mohammed , Jawad K. Oleiwi , Falah H. Ihmedee , Tijjani Adam , Bashir O. Betar , Subash C.B. Gopinath","doi":"10.1016/j.ntm.2025.100097","DOIUrl":"10.1016/j.ntm.2025.100097","url":null,"abstract":"<div><div>This review provides a comprehensive analysis of Zinc Oxide Nanoparticles (ZnO NPs) in biomedical applications, focusing on their anticancer, antioxidant, and antimicrobial properties. ZnO NPs, distinguished by their unique physicochemical attributes, are increasingly recognized in nanomedicine for their potential in cancer therapy, oxidative stress management, and infection control. The synthesis and characterization of ZnO NPs, crucial for their functionality and safety, are discussed, emphasizing the impact of particle size, morphology, and purity. ZnO NPs exhibit promising capabilities in oncology through reactive oxygen species generation, apoptosis induction, and anti-proliferative effects. Their efficacy against diverse cancer types and insights from emerging clinical trials are evaluated. The review also highlights the antioxidant properties of ZnO NPs, comparing their effectiveness with conventional antioxidants and their role in combating oxidative stress-related diseases, supported by case studies. The antimicrobial potential of ZnO NPs is explored through their interaction with microbial cell structures and the generation of reactive oxygen species, demonstrating their broad-spectrum efficacy against bacteria, fungi, and viruses. Applications in healthcare and infection control are discussed. Furthermore, the review addresses biocompatibility and toxicity concerns, covering in vitro and in vivo studies, factors influencing toxicity, and regulatory perspectives. Challenges in clinical applications, including delivery systems and translational research obstacles, are examined. Finally, the review outlines future prospects, such as emerging research trends, potential in combined therapies, and advancements in nanotechnology, concluding with the pivotal role of ZnO NPs in advancing therapeutic solutions and their promising future in healthcare.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats 利用二氧化硅纳米颗粒嫁接抗坏血酸缓解大鼠氧化应激和脑活动受损

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-01-28 DOI: 10.1016/j.ntm.2025.100074

Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Marwa Kechnebbou , Salem Amara

{"title":"Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats","authors":"Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Marwa Kechnebbou , Salem Amara","doi":"10.1016/j.ntm.2025.100074","DOIUrl":"10.1016/j.ntm.2025.100074","url":null,"abstract":"<div><div>The brain has natural antioxidant defense systems, functioning through enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase, which neutralize reactive oxygen species (ROS). Once these defense systems are overwhelmed by poisoning, oxidative damage can occur in the brain. In this study, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) was used to induce oxidative stress. Ascorbic acid grafted to silica nanoparticles (SiO<sub>2</sub>-NPs@AA) was used as a therapeutic strategy aimed to reduce ROS levels and enhancing antioxidant defenses. The SiO<sub>2</sub>-NPs@AA were synthesized and characterized, showing efficient functionalization with ascorbic acid. The in-vitro, antioxidant assays revealed that SiO<sub>2</sub>-NPs@AA exhibited significant radical scavenging activity (DPPH and hydroxyl radicals) and high iron-chelating ability with enhanced stability compared to free ascorbic acid. Moreover, the in-vivo study demonstrated that SiO<sub>2</sub>-NPs@AA mitigated H<sub>2</sub>O<sub>2</sub>-induced effects in key enzymes, including superoxide dismutase, catalase, glutathione (GSH), and restore acetylcholinesterase (AChE) levels. Notably, malondialdehyde (MDA) levels, a marker of lipid peroxidation, were significantly reestablished in the frontal cortex and hippocampus following SiO<sub>2</sub>-NPs@AA. Overall, the study revealed that SiO<sub>2</sub>-NPs@AA corrected effectively nitric oxide (NO) and monoamine oxidase activities, which confirm their role to preserve neuronal function and mitigate neurotoxicity.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation 利用纳米颗粒技术进行头颈癌的精准医疗：靶向递送、免疫调节和临床转化

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-02-21 DOI: 10.1016/j.ntm.2025.100075

Karthikeyan Elumalai , Sivaneswari Srinivasan

{"title":"Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation","authors":"Karthikeyan Elumalai , Sivaneswari Srinivasan","doi":"10.1016/j.ntm.2025.100075","DOIUrl":"10.1016/j.ntm.2025.100075","url":null,"abstract":"<div><div>Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficiency and targeting. Researchers are studying different kinds of NPs, like liposomal, polymeric, dendritic, and gold nanoparticles (AuNPs), to see how they can improve drug delivery and change the tumour environment. To improve treatment results, we use specific strategies like targeting receptors, releasing substances inside cells in a controlled way, and adjusting the immune response. The review talks about how NPs focus on cancer-related fibroblasts, stop new blood vessel growth, and tackle problems in moving these treatments into real-world use. These issues include safety, toxicity, being able to produce them on a large scale, and following regulations. Finally, emerging trends, such as hybrid NPs and personalized nanomedicine, are proposed. Nanoparticle technology can greatly change how we treat head and neck cancer. It can improve how drugs are delivered, alter the environment around tumours, and tailor treatments to individual patients, which can make life better for them. This could lead to a new approach in cancer care.in cancer treatment.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations 抗氧化纳米配方减轻环境污染物的氧化应激毒性

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-05-09 DOI: 10.1016/j.ntm.2025.100087

Hamieh Goshtasbi , Nastaran Hashemzadeh , Marziyeh Fathi , Ali Movafeghi , Jaleh Barar , Yadollah Omidi

{"title":"Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations","authors":"Hamieh Goshtasbi , Nastaran Hashemzadeh , Marziyeh Fathi , Ali Movafeghi , Jaleh Barar , Yadollah Omidi","doi":"10.1016/j.ntm.2025.100087","DOIUrl":"10.1016/j.ntm.2025.100087","url":null,"abstract":"<div><div>Oxidative stress arising from reactive oxygen and nitrogen species (RONS) imposes a severe threat to living organisms by causing extensive cellular and subcellular damage. Environmental pollutants (e.g., xenoestrogens, pesticides, heavy metals, and polycyclic aromatic hydrocarbons) further amplify RONS generation, disrupting mitochondrial function and triggering chronic inflammation. Mitochondrial dysfunction not only hinders energy metabolism but also facilitates the release of pro-apoptotic factors (e.g., cytochrome c), ultimately leading to programmed cell death. Consequently, heightened oxidative stress and mitochondrial impairment are key contributors to a range of chronic illnesses, including metabolic, cardiovascular, endocrine, reproductive, neurodegenerative diseases like Alzheimer’s disease, and cancer. While exogenous antioxidants have shown potential in neutralizing RONS and alleviating oxidative damage, clinical applications are hampered by poor bioavailability, instability, and limited cellular uptake. Antioxidant nanoformulations, particularly those employing biodegradable lipidic and polymeric nanocarriers, offer a promising strategy to address these challenges. Formulated nanoscale delivery systems and bioengineered nanocarriers have been developed for the delivery of antioxidants, which have enhanced antioxidant stability and targeted delivery, and improved therapeutic outcomes. This review discusses the latest advances in nanocarrier-based antioxidant therapies, emphasizing their capacity to mitigate toxicities induced by environmental pollutants and oxidative stress, ultimately opening new prospects for disease management and preventive healthcare.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun based functional scaffolds for biomedical engineering: A review 生物医学工程中基于电纺丝的功能支架的研究进展

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.ntm.2024.100055

Laldinthari Suamte, Punuri Jayasekhar Babu

{"title":"Electrospun based functional scaffolds for biomedical engineering: A review","authors":"Laldinthari Suamte, Punuri Jayasekhar Babu","doi":"10.1016/j.ntm.2024.100055","DOIUrl":"10.1016/j.ntm.2024.100055","url":null,"abstract":"<div><div>Tissue engineering (TE) has made significant strides and progress in the development of functional biomaterials. Among different techniques that has been adopted, electrospinning is a versatile and widely adopted fabrication process for creating biomedical scaffolds. These intricate 3-dimensional matrices play a crucial role in various tissue engineering applications. Electrospinning is a technique commonly utilized in TE as it produces ultrafine fibres through an electric field to draw polymer solutions, melting them into thin fibres. These fibres form a scaffold with a high surface area-to-volume ratio, making them ideal for tissue engineering. This review discusses the various biomedical applications of electrospun scaffolds in different fields, such as dentistry, bone regeneration, wound healing, bone marrow regeneration, vascular tissue engineering, corneal regeneration and liver tissue engineering. Also, this review highlights the multiple parameters affecting the design of the scaffolds for tissue regeneration. As research in this field continues, electrospun scaffolds are likely to become more reliable and effective. Their ability to mimic natural tissue structures and promote cellular interactions positions them as a promising avenue for future biomedical advancements.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction 硒，银和金纳米颗粒：肝脏氧化应激和炎症减少的新策略

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-05-07 DOI: 10.1016/j.ntm.2025.100085

Karthik K Karunakar , Binoy Varghese Cheriyan , Dheena Babu , Devan P , Nandhini J , Suresh Kannan M , Lincy Yabase , Kunal Kataria

{"title":"Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction","authors":"Karthik K Karunakar , Binoy Varghese Cheriyan , Dheena Babu , Devan P , Nandhini J , Suresh Kannan M , Lincy Yabase , Kunal Kataria","doi":"10.1016/j.ntm.2025.100085","DOIUrl":"10.1016/j.ntm.2025.100085","url":null,"abstract":"<div><div>Liver failure, primarily driven by oxidative stress and inflammation, remains a significant clinical challenge. Conventional hepatoprotective strategies often fail to provide effective long-term protection, necessitating the exploration of novel therapeutic approaches. This review focuses on the hepatoprotective potential of selenium (SeNPs), silver (AgNPs), and gold nanoparticles (AuNPs), emphasizing their antioxidant, anti-inflammatory, and immunomodulatory mechanisms. SeNPs enhance antioxidant defenses by scavenging reactive oxygen species (ROS) and upregulating key enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). AgNPs exhibit anti-inflammatory effects by modulating cytokine expression, reducing lipid peroxidation, and preserving hepatic architecture. AuNPs demonstrate biocompatibility, fibrosis prevention, and immune modulation through NF-κB and Nrf2 signaling. Despite their therapeutic promise, concerns regarding nanoparticle biocompatibility, stability, and potential toxicity remain key challenges for clinical translation. This review aims to explore the role of (SeNPs), (AgNPs), and (AuNPs) in mitigating oxidative stress and inflammation in liver diseases, explore their mechanisms of hepatoprotection, assess the challenges associated with their biomedical applications, and provide insights into future directions for their clinical development. Addressing these gaps will be crucial in optimizing nanoparticle-based hepatoprotective therapies for safer and more effective liver disease management.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy based on EV biomarkers: A new frontier for early diagnosis and prognosis assessment of cancer at ESMO 2024 基于EV生物标志物的液体活检：癌症早期诊断和预后评估的新前沿

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1016/j.ntm.2025.100084

Zeping Shan , Xinming Su , Luqing Liu, Shiwei Duan

引用次数: 0

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines 用于药物递送的纳米颗粒：纳米药物在体外和体内的药物释放

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-04-24 DOI: 10.1016/j.ntm.2025.100083

Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie

{"title":"Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines","authors":"Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie","doi":"10.1016/j.ntm.2025.100083","DOIUrl":"10.1016/j.ntm.2025.100083","url":null,"abstract":"<div><div>Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles, methods of evaluating the drug release, <em>in vitro-in vivo</em> correlation, and regulatory challenges associated with nano-formulations. Nanoparticles have been classified into organic, inorganic, and hybrid nanoparticles. Several techniques, such as separated flow, continuous flow, and dialysis methods, have been utilized to assess nano-formulations' <em>in vitro</em> release. In <em>vivo</em> drug release evaluations in biological systems have also been demonstrated. Such evaluations often involve experimental models for the distribution of the nanoparticles, hematology, clearance, histopathology, and serum chemistry. Protein binding, enzymatic degradation, lipid absorption, carbohydrate absorption, and attachment to nucleic acid are some factors shown to affect drug release. <em>In vitro-in-vivo</em> correlation (IVIVC) involves the analysis of the drug release results and mathematical correlations. Factors such as the physicochemical properties of the nanoformulations, the subject’s physiological properties, and the formulation’s biopharmaceutical properties relative to the subject usually affect the correlation. Unlike previous reviews, this article uniquely combines mechanistic insights, production methods, stimuli-responsive systems, and regulatory considerations into a single reference, thereby offering a practical and translational perspective for researchers and formulators. This review also identifies current gaps in IVIVC standardization and highlights opportunities for advancing nanoformulation safety and efficacy.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in electrochemical biosensors for bacterial detection 用于细菌检测的电化学生物传感器研究进展

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-03-11 DOI: 10.1016/j.ntm.2025.100078

Yunyang Zhou , Qingcui Wang , Ting Xiang , Xiaohua Chen

{"title":"Recent advances in electrochemical biosensors for bacterial detection","authors":"Yunyang Zhou , Qingcui Wang , Ting Xiang , Xiaohua Chen","doi":"10.1016/j.ntm.2025.100078","DOIUrl":"10.1016/j.ntm.2025.100078","url":null,"abstract":"<div><div>Accurate and efficient bacterial detection remains a critical challenge in clinical diagnostics and public health. Conventional methods are often constrained by low sensitivity and labor-intensive workflows. In contrast, electrochemical sensors offer distinct advantages: high sensitivity, rapid response, cost-effectiveness, and ease of use. The advancement of electrochemical sensors for bacterial detection relies on the continuous optimization of fundamental sensing architectures and the integration of advanced technologies. This review adopts a dual foundation-to-frontier framework. Analyzing essential sensor components such as functional nanomaterials for interface engineering, precisely engineered biorecognition elements, and established electrochemical detection methodologies. Simultaneously, through an advanced technological lens, we explore cutting-edge interdisciplinary innovations such as dual-modal sensing systems, flexible sensor architectures, and artificial intelligence-driven analytical systems. By synthesizing foundational principles and technological innovations, this review not only informs rational sensor design but also delineates the transition toward miniaturized, intelligent, and high-throughput systems for precision medicine and environmental monitoring. This work aims to offer forward-looking guidance for the future development of bacterial detection technologies.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0