Nano TransMed最新文献

{"title":"Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract","authors":"Megha B. Abbigeri ,&nbsp;Bothe Thokchom ,&nbsp;Sapam Riches Singh ,&nbsp;Santosh Mallikarjun Bhavi ,&nbsp;B.P. Harini ,&nbsp;Ramesh Babu Yarajarla","doi":"10.1016/j.ntm.2025.100070","DOIUrl":"10.1016/j.ntm.2025.100070","url":null,"abstract":"<div><div>The weed <em>Martynia annua</em> traditionally known as Kakanasika is annual herbaceous plant known for its multiple medicinal properties such as anthelmintic, analgesic, antipyretic, antibacterial, anti-convulsant, anti-fertility, antinociceptive, antioxidant, CNS depressant and wound healing activity. The aqueous root extract of <em>M. annua</em> was subjected to qualitative analysis, revealing the presence of terpeniods, indicative of its rich phytochemicals composition. Utilizing a green synthesis approach, silver nanoparticles (AgNPs) were successfully synthesized from the plant extract. Characterization through UV-Visible spectroscopy, FTIR, DLS, and SEM/EDX confirmed the formation of AgNPs with polygonal morphology and an average size of 64 nm, with the PDI of 0.385. Additionally, the AgNPs demonstrated moderate stability, evidenced by a zeta potential of −21.6 mV. Evaluation of the synthesized AgNPs focused on their anti-diabetic potential. The green synthesized R-AgNPs were potent antioxidant agents. They exhibited significant inhibition of alpha amylase, a pivotal enzyme in carbohydrate metabolism, suggesting their efficacy as anti-diabetic agents. Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. This study highlights the pharmacological importance of <em>M.annua</em>, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. Further investigation into the mechanism of action and clinical efficacy of these AgNPs in diabetes management is warranted.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocarriers in skin cancer treatment: Emerging drug delivery approaches and innovations","authors":"Laxmi A. Jadhav,&nbsp;Satish K. Mandlik","doi":"10.1016/j.ntm.2024.100068","DOIUrl":"10.1016/j.ntm.2024.100068","url":null,"abstract":"<div><h3>Background</h3><div>Skin cancer is a growing global health issue, with rising incidence rates, particularly among Caucasian populations. It is the most common malignancy, contributing significantly to mortality and decreased quality of life worldwide. While surgical interventions remain the primary treatment, there is a pressing need for innovative strategies to reduce the morbidity and mortality associated with the disease. As the burden of skin cancer continues to grow, the medical community is increasingly exploring novel therapeutic approaches to improve patient outcomes.</div></div><div><h3>Main body</h3><div>Nanotechnology has introduced new possibilities for treating skin cancer, offering advantages in targeted drug delivery, advanced imaging, and diagnostics. Nanomaterials are especially useful in dermatology, as they enhance the penetration and retention of therapeutic agents while minimizing side effects. Various nanomaterials have been studied for their potential in treating skin disorders, including cancer. This review examines the role of nanotechnology in skin cancer treatment, focusing on the development and design of nanocarriers for the precise delivery of drugs. We also discuss the advantages of nanotechnology over traditional treatments, such as improved bioavailability and targeted action. Additionally, we explore clinical trials, patents and FDA approved products related to nanocarrier-based treatments for cancer and skin cancer, highlighting advancements in the field.</div></div><div><h3>Conclusion</h3><div>Nanotechnology holds significant promise in revolutionizing skin cancer treatment. As research progresses, it is expected that more effective, personalized therapies will emerge, ultimately improving patient outcomes. Integrating nanotechnology into clinical practice could elevate the standard of care, offering new hope in managing skin cancer.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano delivery systems in stem cell therapy: Transforming regenerative medicine and overcoming clinical challenges","authors":"Aswini Rajendran,&nbsp;Rithi Angelin Rajan,&nbsp;Saranya Balasubramaniyam,&nbsp;Karthikeyan Elumalai","doi":"10.1016/j.ntm.2024.100069","DOIUrl":"10.1016/j.ntm.2024.100069","url":null,"abstract":"<div><div>Stem cell therapy has emerged as a promising approach in regenerative medicine, offering potential treatments for various degenerative diseases and injuries. However, the clinical application of stem cell therapy faces challenges such as low cell viability, inefficient delivery to target sites, and immune rejection. Nanodelivery systems (NDS) have the potential to address these limitations and enhance the efficacy of stem cell-based treatments. This review looks at how NDS can help stem cell therapy work well by creating a safe environment, allowing targeted delivery, and making it easier to control the release of therapeutic factors. The article discusses various types of NDS, including liposomes, polymeric nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, and magnetic nanoparticles, highlighting their unique properties and advantages in stem cell therapy applications. Furthermore, the review examines the potential of NDS in specific areas of regenerative medicine, such as cardiovascular regeneration, neurodegenerative diseases, musculoskeletal tissue repair, and wound healing. The article also addresses the challenges and limitations associated with NDS, such as biocompatibility, toxicity, manufacturing scalability, and regulatory hurdles. Finally, the article explores the future trajectory of nanotechnology in stem cell therapy, discussing the utilization of intelligent nanoparticles, precision genetic modifications, and the benefits of personalized nanomedicine.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression","authors":"Vinotha Mani ,&nbsp;Keerthana Shrri Gopinath ,&nbsp;Nithya Varadharaju ,&nbsp;Dapkupar Wankhar ,&nbsp;Arjunan Annavi","doi":"10.1016/j.ntm.2024.100049","DOIUrl":"10.1016/j.ntm.2024.100049","url":null,"abstract":"<div><h3>Background</h3><div>Integrating nanomedicines for targeted cancer treatment and pursuing medicinally valuable components from nature are crucial for sustainable, potent alternatives to synthetic drugs in combating fatal diseases like cancer. Hence, a green synthesis of nickel oxide (NiO NPs) and zinc oxide nanoparticles (ZnO NPs) has been carried out by using the leaf extract of medicinally important plant <em>Abutilonindicum</em>. This sustainable approach to medical developments not only reduces the environmental effect of standard synthesis methods and offers new options for novel cancer therapeutics, but it also advances public health by using natural resources in a sustainable manner.</div></div><div><h3>Methods</h3><div>The synthesized nanoparticles were characterized by employing spectro-analytical techniques like UV–vis, FT-IR, SEM and powder XRD. Synthesized nanparticles were evaluated in the human cervical cancer cells (HeLa).</div></div><div><h3>Results</h3><div>Ni-O stretching vibrations were observed at 402 cm⁻¹, whereas that of Zn-O stretching was observed at 409 cm⁻¹in the FT-IR spectrum, confirming the formation of nanoparticles. The XRD pattern revealed the crystallite size range of 1.35–2.84 nm for NiO NPs and 7.71–56.80 nm for ZnO NPs. The morphology of the nanoparticles, as indicated by the SEM images, was rod-like for NiO NPs and rock-shaped for ZnO NPs. Further, the cancer cell growth inhibition activity of the nanoparticles was examined by MTT assay against human cervical cancer cells (HeLa) proliferation and compared with <em>cisplatin</em>. MTT assay elucidated the significant anticancer efficacy of the synthesized nanoparticles, showcasing low IC₅₀ values of 29±0.5 µg/ml for NiO NPs and 32±0.7 µg/ml for ZnO NPs. Furthermore, the anticancer activity of the NiO NPs was investigated using the Trypan blue dye exclusion technique, emphasizing the pronounced cytotoxic impact of NiO NPs on cancer cell viability. The outcomes underscore the notable anticancer properties of plant extract mediated metal nanoparticles as promising contenders for advancing cancer treatment modalities.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoindentation: Introduction and applications of a non-destructive analysis","authors":"Zaid H. Mahmoud ,&nbsp;H.N.K. AL-Salman ,&nbsp;Ehsan Kianfar","doi":"10.1016/j.ntm.2024.100057","DOIUrl":"10.1016/j.ntm.2024.100057","url":null,"abstract":"<div><div>Nanoindentation test is known as a powerful method for non-destructive characterization and analysis of mechanical properties of nanoscale materials. In this method, the indenting tip penetrates the surface of the sample by applying a force of several millinewtons to the extent of several nanometers, and the resulting force-displacement curve is used as the output of the test to calculate the mechanical characteristics of the sample, including hardness and elastic modulus, as well as to identify various mechanical phenomena such as Creep, strain hardening, surface cracking, phase transformations, creep and fracture toughness of the material are used. In this article, the Nanoindentation method is briefly introduced and its principles and basics are discussed. The application of this method is valid for analyzing the mechanical properties of a wide range of materials. The purpose of this article is to familiarize researchers and experts in engineering fields with the nanoindentation method as a non-destructive analysis and its effective use in their respective fields of application.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology-based advancements for effective delivery of phytoconstituents for Ocular diseases","authors":"Venkateshwaran Krishnaswami ,&nbsp;Dhilin Pathayappurakkal Mohanan ,&nbsp;S.A. Jacob Raja ,&nbsp;Balakrishnan Natarajan ,&nbsp;Shankarananth Velusamy","doi":"10.1016/j.ntm.2024.100056","DOIUrl":"10.1016/j.ntm.2024.100056","url":null,"abstract":"<div><div>Phytomedicines has been globally utilized in ancient times. Phytoconstituents such as flavonoids, glycosides, peptides, carbohydrates, lipids, alkaloids, tannins, and terpenoids are holding medicinal properties. Previous reports have documented the various therapeutic activities of plant extracts/isolated fractions/pure phytoconstituents especially at in vitro levels. But the relevance towards the in vivo level and upmost towards the clinical trials for these phytomedicines was facing numerous challenges in the current scenario. The challenges associated with phytomedicines are standardization issues, ineffective against serious ailments, poor reproducibility of biological activities and interferences with associated phytoconstituents. But recently nanoscale based phytomedicine is paving more interest towards the scientific community for ocular delivery. In order to overcome these issues the nanoscale base phytomedicines delivery systems are recently developed by researchers. Nanoscale delivery systems of various phytoconstituents may potentiate the therapeutic effect, improves the bioavailability, reduces adverse effects and decreases the effective dose. The scope of this paper will focus towards the nanotechnology based phytomedicine delivery systems for various therapeutic applications in eye. The various phytomedicine loaded nanoscale delivery systems such as nanoparticles, nanomicelles, nanodispersions, lipid based nanoparticles for various ocular diseases has been reviewed. Special focus has been emphasized towards the carriers utilized for those delivery systems. Additionally, the future perspectives relating to development of novel phytomedicine based nano formulations has been discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer lipid-based drug delivery systems: Basic knowledge and recent applications","authors":"Mohamed M. Shehata","doi":"10.1016/j.ntm.2024.100054","DOIUrl":"10.1016/j.ntm.2024.100054","url":null,"abstract":"<div><div>Cancer is a complicated disease that thrives on certain features collectively known as cancer hallmarks (e.g. growth signals autonomy, evading apoptosis, evading immune system, ability of metastasis, etc.). Anticancer drugs suffer from low bioavailability and severe side effects due to the arsenal of barriers (e.g. tumor microenvironment, efflux proteins, etc.) cancer have to hinder their delivery. Consequently, passive and active targeting of anticancer drugs is a necessity. Lipid based nano drug delivery systems (DDS) (e.g. liposomes, niosomes, self-emulsifying DDS, solid lipid nanoparticles and nanostructured lipid carriers), emerges as an approach of smart delivery of the anticancer drug. Therefore, achieving targetability, safety and efficacy. Lipid based DDS proved applicability and did not stop at the point of delivering anticancer drugs. They extended their mission to fighting anticancer multiple drug resistance, protection of cancer vaccination agents and therapeutic nucleic acids molecules. Furthermore, they achieved additional diagnostic roles (i.e. theranostics) and showed flexibility to be formulated for different routes of administration. They combined physical stimuli responsive therapy with pharmacological therapy, to name a few.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and enterprise standard for producing and monitoring of quality extracellular vesicles /exosomes derived from human mesenchymal stem cells","authors":"Qilong Cao ,&nbsp;Rui Zhang ,&nbsp;Association & Enterprise Standard Drafting Committee,&nbsp;Qingsong Ye","doi":"10.1016/j.ntm.2024.100058","DOIUrl":"10.1016/j.ntm.2024.100058","url":null,"abstract":"<div><div>This document is drafted in accordance with GB/T 1.1–2020 \"<em>Standardization work guidelines Part 1: Structure and drafting rules for standardization documents</em>\" to specify the identification methods, inspection rules, label, package,storage, transportation and waste disposal requirement of extracellular vesicles (EVs)/exosomes derived from human mesenchymal stem cells. Please note that certain contents of this document may refer to patents, and the issuing institution of this document does not assume responsibility for identifying patents. This document is led by Qingdao Haier Biotechnology Co. Ltd. in collaboration with other 80 biological companies, institutions and hospitals in China. This document is collectively contributed by 122 experts in stem cell field, and officially released by China Food and Drug Corporation Quality and Safety Promotion Association. Publication of this document in current version has been approved by the group leader Qingdao Haier Biotechnology Co, Ltd.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death","authors":"Astha Sharma ,&nbsp;Jiachen Yan ,&nbsp;Prakrit Siwakoti ,&nbsp;Ayad Saeed ,&nbsp;Vipul Agarwal ,&nbsp;Zhi Ping Xu ,&nbsp;Ran Wang ,&nbsp;Tushar Kumeria","doi":"10.1016/j.ntm.2024.100053","DOIUrl":"10.1016/j.ntm.2024.100053","url":null,"abstract":"<div><div>Encapsulation of drugs into nanocarriers is proven to be highly promising approach in reducing drug toxicity and enhancing therapeutic efficacy. However, controlling the loading efficiency and capacity, and release of therapeutics at specific disease site has remained a key challenge, particularly for toxic chemotherapeutic drugs. This work explored the effect of treatment with empty silica nanoparticles (SNPs) and a chemotherapeutic drug either together (i.e. co-treatment) or in tandem (i.e. temporally spaced) on the cell ablation ability of the drug. The study also investigated whether the efficacy of the drug in response to these treatments was dependent on the morphology of particles. SNPs of four different morphologies (solid: SSNPs, dendritic: DSNPs, mesoporous: MSNPs, and rod: RSNP) were used, while cisplatin (CisPt) served as model chemotherapeutic. The efficacy of CisPt as a function of SNPs morphology and temporal treatment strategy was tested in HeLa cells. The results indicated that the morphology of particles as well as treatment strategy (i.e. co-incubation and post treatment) had an impact on not only the cell viability but also the cell death pathways, as evidenced by varying IC50 values and the flow cytometry analysis. Interestingly, co-treatment of SNPs with CisPt resulted in an across-the-board lower IC50 value compared to when the cells were first treated with SNPs for 24 h followed by CisPt treatment and even when CisPt was loaded into the particles for most of the SNPs.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic silver nanoparticles from Simarouba glauca DC leaf extract: Synthesis, characterization, and anticancer efficacy in lung cancer cells with protective effects in Caenorhabditis elegans","authors":"Santosh Mallikarjun Bhavi ,&nbsp;Akshata Choudhari Padti ,&nbsp;Bothe Thokchom ,&nbsp;Sapam Riches Singh ,&nbsp;Shivanand S. Bhat ,&nbsp;Sukesh Kumar Bajire ,&nbsp;Rajesh P. Shastry ,&nbsp;B.S. Srinath ,&nbsp;Sushma Subraya Gummani ,&nbsp;B.P. Harini ,&nbsp;Ramesh Babu Yarajarla","doi":"10.1016/j.ntm.2024.100052","DOIUrl":"10.1016/j.ntm.2024.100052","url":null,"abstract":"<div><div>This study explores the synthesis, characterization, and biomedical applications of silver nanoparticles (AgNPs) synthesized using <em>Simarouba glauca</em> leaf extract. The biogenic AgNPs were characterized through UV–visible spectroscopy, X-ray diffraction (XRD), particle size analysis, zeta potential analysis, energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The nanoparticles exhibited a distinct absorbance peak at 413.5 nm, confirming their synthesis and surface plasmon resonance. XRD and HR-TEM analyses revealed a face-centered cubic structure with an average size of 12.45 nm, while AFM indicated a mean particle size of 18.34 nm. The particles demonstrated moderate stability with a zeta potential of −41.4 mV and exhibited various elemental compositions as confirmed by EDX. In the biomedical evaluation, the anticancer potential of SG-AgNPs was tested on L-132 and A549 cell lines using MTT, live/dead, and DNA damage assays. Results showed dose-dependent cytotoxicity, with significant effects observed at higher concentrations, particularly against A549 cells. Additionally, the protective effects of SG-AgNPs were assessed in <em>Caenorhabditis elegans</em> using survival and paralysis assays. The nanoparticles significantly improved survival rates and reduced paralysis in worms infected with <em>Pseudomonas aeruginosa</em> PAO1 and <em>Staphylococcus aureus</em>. These findings highlight the potential of biogenic SG-AgNPs as effective agents with both anticancer and antimicrobial properties. Future research should focus on elucidating the mechanisms underlying these effects and optimizing their therapeutic applications.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}