脂质体包封疗法:炎性肺疾病的精准医学

Mohammad Arshad Javed Shaikh , Kavita Goyal , Muhammad Afzal , R. Roopashree , Mukesh Kumari , T. Krithiga , Rajashree Panigrahi , Suman Saini , Haider Ali , Mohd Imran , Abida , Tarun Patodia , Gaurav Gupta
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引用次数: 0

摘要

相对于其他纳米复合材料,脂质体已成为运输具有治疗潜力的各种疏水和亲水化合物的首选。这主要是由于它们特殊的降解能力、生物系统内的相容性和最小的免疫原性。脂质体已经证明了它们增强药物溶解度和分布的能力。此外,它们可以经过表面修饰,以实现持续、延长和有针对性的释放。炎症性肺部疾病,如哮喘、肺癌、肺损伤、肺结核、特发性肺纤维化(IPF)和慢性阻塞性肺疾病(COPD)极大地受益于脂质体独特的治疗和管理品质。本文概述了目前对脂质体系统在治疗肺部炎症性疾病的药物递送中的功效的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liposome-encapsulated therapies: Precision medicine for inflammatory lung disorders
Liposomes have emerged as the preferred choice over other nanocomposites for transporting a wide range of hydrophobic and hydrophilic compounds with therapeutic potential. This is primarily due to their exceptional degradation ability, compatibility within biological systems, and minimal immunogenicity. Liposomes have demonstrated their ability to enhance the solubility and distribution of medications. Moreover, they can undergo surface modifications to enable sustained, prolonged, and targeted release. Inflammatory lung disorders such as asthma, lung cancer, lung damage, tuberculosis, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) greatly benefit from liposomes' unique treatment and management qualities. This article provides an overview of the current understanding of liposomal systems' efficacy in drug delivery for managing pulmonary inflammatory diseases.
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