Nano TransMed最新文献

Redox-sensitive camptothecin prodrug: A promising drug delivery strategy with ultrahigh drug loading and tunable drug release 氧化还原敏感喜树碱前药：一种具有超高载药量和可调药物释放的有前途的药物递送策略

Nano TransMed Pub Date : 2025-05-11 DOI: 10.1016/j.ntm.2025.100088

Shiwei Fu , Vanessa Puche , Bowen Zhao , Xiao Zhang , Victoria A.A. McKenzie , Sophia Garcia , Fuwu Zhang

{"title":"Redox-sensitive camptothecin prodrug: A promising drug delivery strategy with ultrahigh drug loading and tunable drug release","authors":"Shiwei Fu , Vanessa Puche , Bowen Zhao , Xiao Zhang , Victoria A.A. McKenzie , Sophia Garcia , Fuwu Zhang","doi":"10.1016/j.ntm.2025.100088","DOIUrl":"10.1016/j.ntm.2025.100088","url":null,"abstract":"<div><div>Small molecular drugs play a critical role in cancer therapy but face challenges like poor solubility, severe side effects, and inefficient delivery. Polymeric micellar-based drug delivery systems show promise but struggle with low drug loading, instability, and premature drug release partly due to the incompatible physicochemical properties. Here, we report a simple and efficient method to develop redox-sensitive camptothecin (CPT) prodrug by conjugating alkyl chains to CPT via a disulfide linker. By conjugating alkyl chains of varying lengths to CPT via a disulfide linker, we achieved high drug-loading efficiency and loading capacity, controlled responsive drug release, due to enhanced hydrophobic interaction and miscibility with the carrier. The prodrug loaded NPs exhibited slower drug release for more hydrophobic ones with longer alky chains. In vitro cytotoxicity assays against cancer cells confirmed the prodrugs' potency and the critical role of the disulfide bond in maintaining anticancer activity. These findings highlight the importance of tuning prodrug hydrophobicity and GSH sensitivity in drug delivery. This prodrug engineering strategy, which involves conjugating a hydrophobic alkyl chain to modulate the drug's physicochemical properties, offers a straightforward approach for designing and optimizing drug delivery systems for a wide range of therapeutic agents, whether hydrophilic or hydrophobic.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations 抗氧化纳米配方减轻环境污染物的氧化应激毒性

Nano TransMed Pub Date : 2025-05-09 DOI: 10.1016/j.ntm.2025.100087

Hamieh Goshtasbi , Nastaran Hashemzadeh , Marziyeh Fathi , Ali Movafeghi , Jaleh Barar , Yadollah Omidi

{"title":"Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations","authors":"Hamieh Goshtasbi , Nastaran Hashemzadeh , Marziyeh Fathi , Ali Movafeghi , Jaleh Barar , Yadollah Omidi","doi":"10.1016/j.ntm.2025.100087","DOIUrl":"10.1016/j.ntm.2025.100087","url":null,"abstract":"<div><div>Oxidative stress arising from reactive oxygen and nitrogen species (RONS) imposes a severe threat to living organisms by causing extensive cellular and subcellular damage. Environmental pollutants (e.g., xenoestrogens, pesticides, heavy metals, and polycyclic aromatic hydrocarbons) further amplify RONS generation, disrupting mitochondrial function and triggering chronic inflammation. Mitochondrial dysfunction not only hinders energy metabolism but also facilitates the release of pro-apoptotic factors (e.g., cytochrome c), ultimately leading to programmed cell death. Consequently, heightened oxidative stress and mitochondrial impairment are key contributors to a range of chronic illnesses, including metabolic, cardiovascular, endocrine, reproductive, neurodegenerative diseases like Alzheimer’s disease, and cancer. While exogenous antioxidants have shown potential in neutralizing RONS and alleviating oxidative damage, clinical applications are hampered by poor bioavailability, instability, and limited cellular uptake. Antioxidant nanoformulations, particularly those employing biodegradable lipidic and polymeric nanocarriers, offer a promising strategy to address these challenges. Formulated nanoscale delivery systems and bioengineered nanocarriers have been developed for the delivery of antioxidants, which have enhanced antioxidant stability and targeted delivery, and improved therapeutic outcomes. This review discusses the latest advances in nanocarrier-based antioxidant therapies, emphasizing their capacity to mitigate toxicities induced by environmental pollutants and oxidative stress, ultimately opening new prospects for disease management and preventive healthcare.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based nanotherapeutics: A new frontier in disease management and prevention 植物纳米疗法：疾病管理和预防的新前沿

Nano TransMed Pub Date : 2025-05-08 DOI: 10.1016/j.ntm.2025.100086

Sumitha Elayaperumal , Yuvaraj Sivamani , Parth Agarwal , Nimmy Srivastava

{"title":"Plant-based nanotherapeutics: A new frontier in disease management and prevention","authors":"Sumitha Elayaperumal , Yuvaraj Sivamani , Parth Agarwal , Nimmy Srivastava","doi":"10.1016/j.ntm.2025.100086","DOIUrl":"10.1016/j.ntm.2025.100086","url":null,"abstract":"<div><div>Nanotechnology has emerged as a transformative force in the field of medicine, offering innovative solutions for the diagnosis, treatment, and prevention of diseases. Among the myriad sources of nanomaterials, plant-based nanotherapeutics stand out due to their biocompatibility, eco-friendliness, and potential for sustainable production. These nanomaterials show promise across a range of diseases, demonstrating significant anticancer activity and potent antimicrobial properties against bacterial, viral, and fungal infections. Additionally, their applications in managing diabetes, reducing inflammation, and promoting wound healing highlight their versatility and effectiveness. Despite challenges such as scaling up nanoparticle production, ensuring stability, and creating standardized regulatory frameworks, the future of plant-based nanotherapeutics is promising. As the field advances, plant-based nanotherapeutics have the potential to transform healthcare by providing more effective, safe, and eco-friendly treatment options. This review article delves into the burgeoning field of plant-based nanotherapeutics, highlighting their mechanisms of action, and diverse applications in disease treatment.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction 硒，银和金纳米颗粒：肝脏氧化应激和炎症减少的新策略

Nano TransMed Pub Date : 2025-05-07 DOI: 10.1016/j.ntm.2025.100085

Karthik K Karunakar , Binoy Varghese Cheriyan , Dheena Babu , Devan P , Nandhini J , Suresh Kannan M , Lincy Yabase , Kunal Kataria

{"title":"Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction","authors":"Karthik K Karunakar , Binoy Varghese Cheriyan , Dheena Babu , Devan P , Nandhini J , Suresh Kannan M , Lincy Yabase , Kunal Kataria","doi":"10.1016/j.ntm.2025.100085","DOIUrl":"10.1016/j.ntm.2025.100085","url":null,"abstract":"<div><div>Liver failure, primarily driven by oxidative stress and inflammation, remains a significant clinical challenge. Conventional hepatoprotective strategies often fail to provide effective long-term protection, necessitating the exploration of novel therapeutic approaches. This review focuses on the hepatoprotective potential of selenium (SeNPs), silver (AgNPs), and gold nanoparticles (AuNPs), emphasizing their antioxidant, anti-inflammatory, and immunomodulatory mechanisms. SeNPs enhance antioxidant defenses by scavenging reactive oxygen species (ROS) and upregulating key enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). AgNPs exhibit anti-inflammatory effects by modulating cytokine expression, reducing lipid peroxidation, and preserving hepatic architecture. AuNPs demonstrate biocompatibility, fibrosis prevention, and immune modulation through NF-κB and Nrf2 signaling. Despite their therapeutic promise, concerns regarding nanoparticle biocompatibility, stability, and potential toxicity remain key challenges for clinical translation. This review aims to explore the role of (SeNPs), (AgNPs), and (AuNPs) in mitigating oxidative stress and inflammation in liver diseases, explore their mechanisms of hepatoprotection, assess the challenges associated with their biomedical applications, and provide insights into future directions for their clinical development. Addressing these gaps will be crucial in optimizing nanoparticle-based hepatoprotective therapies for safer and more effective liver disease management.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy based on EV biomarkers: A new frontier for early diagnosis and prognosis assessment of cancer at ESMO 2024 基于EV生物标志物的液体活检：癌症早期诊断和预后评估的新前沿

Nano TransMed Pub Date : 2025-05-06 DOI: 10.1016/j.ntm.2025.100084

Zeping Shan , Xinming Su , Luqing Liu, Shiwei Duan

引用次数: 0

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines 用于药物递送的纳米颗粒：纳米药物在体外和体内的药物释放

Nano TransMed Pub Date : 2025-04-24 DOI: 10.1016/j.ntm.2025.100083

Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie

{"title":"Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines","authors":"Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie","doi":"10.1016/j.ntm.2025.100083","DOIUrl":"10.1016/j.ntm.2025.100083","url":null,"abstract":"<div><div>Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles, methods of evaluating the drug release, <em>in vitro-in vivo</em> correlation, and regulatory challenges associated with nano-formulations. Nanoparticles have been classified into organic, inorganic, and hybrid nanoparticles. Several techniques, such as separated flow, continuous flow, and dialysis methods, have been utilized to assess nano-formulations' <em>in vitro</em> release. In <em>vivo</em> drug release evaluations in biological systems have also been demonstrated. Such evaluations often involve experimental models for the distribution of the nanoparticles, hematology, clearance, histopathology, and serum chemistry. Protein binding, enzymatic degradation, lipid absorption, carbohydrate absorption, and attachment to nucleic acid are some factors shown to affect drug release. <em>In vitro-in-vivo</em> correlation (IVIVC) involves the analysis of the drug release results and mathematical correlations. Factors such as the physicochemical properties of the nanoformulations, the subject’s physiological properties, and the formulation’s biopharmaceutical properties relative to the subject usually affect the correlation. Unlike previous reviews, this article uniquely combines mechanistic insights, production methods, stimuli-responsive systems, and regulatory considerations into a single reference, thereby offering a practical and translational perspective for researchers and formulators. This review also identifies current gaps in IVIVC standardization and highlights opportunities for advancing nanoformulation safety and efficacy.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposome-encapsulated therapies: Precision medicine for inflammatory lung disorders 脂质体包封疗法：炎性肺疾病的精准医学

Nano TransMed Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100082

Mohammad Arshad Javed Shaikh , Kavita Goyal , Muhammad Afzal , R. Roopashree , Mukesh Kumari , T. Krithiga , Rajashree Panigrahi , Suman Saini , Haider Ali , Mohd Imran , Abida , Tarun Patodia , Gaurav Gupta

引用次数: 0

Boron delivery agents in BNCT: A mini review of current developments and emerging trends 硼在BNCT中的输送剂：目前的发展和新趋势的一个小回顾

Nano TransMed Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100081

Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero Jr.

{"title":"Boron delivery agents in BNCT: A mini review of current developments and emerging trends","authors":"Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero Jr.","doi":"10.1016/j.ntm.2025.100081","DOIUrl":"10.1016/j.ntm.2025.100081","url":null,"abstract":"<div><div>Boron Neutron Capture Therapy (BNCT) is a highly targeted form of radiation therapy offering significant potential for treating hard-to-manage cancers such as glioblastoma, head and neck cancer, and recurrent melanoma <span><span>[1]</span></span>. Its effectiveness relies on the selective accumulation of boron-10 within tumor cells, enabling localized high-linear-energy transfer (high-LET) damage through neutron capture reactions. Despite the promise of this therapeutic approach, the development of efficient boron delivery agents remains a critical challenge. This review explores the evolution of boron delivery agents over three generations, highlighting their advancements, limitations, and emerging trends. Early first-generation agents, such as sodium tetraborate, faced issues with tumor specificity and retention, leading to the introduction of second-generation agents like boronophenylalanine (BPA) and sodium borocaptate (BSH). While these agents improved therapeutic outcomes, they exhibited limitations in tumor uptake mechanisms, selectivity, and retention. Recent advancements have resulted in third-generation agents that integrate nanotechnology, monoclonal antibodies, and multifunctional frameworks, significantly enhancing tumor specificity and therapeutic efficiency. These innovative agents utilize targeted delivery, imaging capabilities, and theranostic functionalities to optimize treatment outcomes. However, challenges remain in overcoming tumor heterogeneity, ensuring regulatory compliance, and scaling up production. This review provides a comprehensive analysis of current developments in boron delivery systems, offering insights into their potential to transform BNCT into a more effective and accessible cancer therapy.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses 生态友好的纳米颗粒植物合成通过植物提取物：机械的见解，最近的进展，和多方面的用途

Nano TransMed Pub Date : 2025-03-21 DOI: 10.1016/j.ntm.2025.100080

Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery

{"title":"Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses","authors":"Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery","doi":"10.1016/j.ntm.2025.100080","DOIUrl":"10.1016/j.ntm.2025.100080","url":null,"abstract":"<div><div>This review explores the phytosynthesis of nanoparticles (NPs) using plant extracts, emphasizing mechanistic insights, recent advancements, and their diverse applications. The green and cost-effective nature of phytosynthesis makes it an attractive alternative to conventional nanoparticle synthesis, with phytochemicals such as flavonoids, phenolics, and alkaloids facilitating metal ion reduction and stabilization. The review highlights key medical applications, including the anticancer potential of gold nanoparticles, which have demonstrated apoptosis induction in cancer cells, and their use in theranostic structures for simultaneous diagnosis and treatment. In environmental science, phytosynthesized iron and silver nanoparticles have shown over 90 % efficiency in heavy metal adsorption and pollutant degradation, contributing to sustainable remediation strategies. In agriculture, nanofertilizers synthesized via phytosynthesis have enhanced crop yields by up to 30 % while reducing chemical fertilizer dependence. Despite these advancements, obstacles persist in scaling up production, ensuring batch-to-batch reproducibility, and fully elucidating nanoparticle interactions at the molecular level. Standardizing synthesis protocols, optimizing plant metabolite compositions, and conducting extensive in vivo studies will be crucial in translating laboratory findings into real-world applications. By resolving these difficulties through interdisciplinary collaborations, phytosynthesized nanoparticles can revolutionize nanomedicine, agriculture, and environmental sustainability, paving the way for the next generation of eco-friendly technological innovations.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and recent progress of MXene-based bioactive materials in wound management mxeni基生物活性材料在伤口治疗中的应用及最新进展

Nano TransMed Pub Date : 2025-03-17 DOI: 10.1016/j.ntm.2025.100079

Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li

{"title":"Application and recent progress of MXene-based bioactive materials in wound management","authors":"Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li","doi":"10.1016/j.ntm.2025.100079","DOIUrl":"10.1016/j.ntm.2025.100079","url":null,"abstract":"<div><div>Wound management is one of the major challenges in the biomedical field, where wound ulceration and bacterial infections cause systemic inflammatory reactions or scarring in patients, seriously affecting the quality of life and causing great economic pressure. Smart bioactive materials offer new therapeutic strategies for wound management and monitoring, providing a tailored option for wound repair. MXene, as a 2D functional and tunable material, exhibits unique advantages and enormous potential in promoting cell growth, angiogenesis, recruiting immune cells, avoiding infections, and biological signal transmission. This review details the benefits of MXene-based materials in the field of tissue repair and addresses the key challenges faced by different wounds, reflecting excellent bioactivity and organismal suitability. Notably, MXene can function as a smart surrogate device, enabling precise assessments for wound monitoring and care. This development signifies a paradigm shift towards a novel era of non-invasive monitoring of the healing cycle. Nevertheless, strategies for regenerative tissue engineering employing MXene-based materials encounter certain challenges and difficulties, which include ensuring long-term bioactive function, developing novel material types, and meeting individual clinical needs. Finally, the future research directions and technological developments of MXene-based materials in wound management were briefly discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0