Nano TransMed最新文献

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines 用于药物递送的纳米颗粒：纳米药物在体外和体内的药物释放

Nano TransMed Pub Date : 2025-04-24 DOI: 10.1016/j.ntm.2025.100083

Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie

{"title":"Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines","authors":"Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie","doi":"10.1016/j.ntm.2025.100083","DOIUrl":"10.1016/j.ntm.2025.100083","url":null,"abstract":"<div><div>Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles, methods of evaluating the drug release, <em>in vitro-in vivo</em> correlation, and regulatory challenges associated with nano-formulations. Nanoparticles have been classified into organic, inorganic, and hybrid nanoparticles. Several techniques, such as separated flow, continuous flow, and dialysis methods, have been utilized to assess nano-formulations' <em>in vitro</em> release. In <em>vivo</em> drug release evaluations in biological systems have also been demonstrated. Such evaluations often involve experimental models for the distribution of the nanoparticles, hematology, clearance, histopathology, and serum chemistry. Protein binding, enzymatic degradation, lipid absorption, carbohydrate absorption, and attachment to nucleic acid are some factors shown to affect drug release. <em>In vitro-in-vivo</em> correlation (IVIVC) involves the analysis of the drug release results and mathematical correlations. Factors such as the physicochemical properties of the nanoformulations, the subject’s physiological properties, and the formulation’s biopharmaceutical properties relative to the subject usually affect the correlation. Unlike previous reviews, this article uniquely combines mechanistic insights, production methods, stimuli-responsive systems, and regulatory considerations into a single reference, thereby offering a practical and translational perspective for researchers and formulators. This review also identifies current gaps in IVIVC standardization and highlights opportunities for advancing nanoformulation safety and efficacy.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposome-encapsulated therapies: Precision medicine for inflammatory lung disorders 脂质体包封疗法：炎性肺疾病的精准医学

Nano TransMed Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100082

Mohammad Arshad Javed Shaikh , Kavita Goyal , Muhammad Afzal , R. Roopashree , Mukesh Kumari , T. Krithiga , Rajashree Panigrahi , Suman Saini , Haider Ali , Mohd Imran , Abida , Tarun Patodia , Gaurav Gupta

引用次数: 0

Boron delivery agents in BNCT: A mini review of current developments and emerging trends 硼在BNCT中的输送剂：目前的发展和新趋势的一个小回顾

Nano TransMed Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100081

Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero Jr.

{"title":"Boron delivery agents in BNCT: A mini review of current developments and emerging trends","authors":"Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero Jr.","doi":"10.1016/j.ntm.2025.100081","DOIUrl":"10.1016/j.ntm.2025.100081","url":null,"abstract":"<div><div>Boron Neutron Capture Therapy (BNCT) is a highly targeted form of radiation therapy offering significant potential for treating hard-to-manage cancers such as glioblastoma, head and neck cancer, and recurrent melanoma <span><span>[1]</span></span>. Its effectiveness relies on the selective accumulation of boron-10 within tumor cells, enabling localized high-linear-energy transfer (high-LET) damage through neutron capture reactions. Despite the promise of this therapeutic approach, the development of efficient boron delivery agents remains a critical challenge. This review explores the evolution of boron delivery agents over three generations, highlighting their advancements, limitations, and emerging trends. Early first-generation agents, such as sodium tetraborate, faced issues with tumor specificity and retention, leading to the introduction of second-generation agents like boronophenylalanine (BPA) and sodium borocaptate (BSH). While these agents improved therapeutic outcomes, they exhibited limitations in tumor uptake mechanisms, selectivity, and retention. Recent advancements have resulted in third-generation agents that integrate nanotechnology, monoclonal antibodies, and multifunctional frameworks, significantly enhancing tumor specificity and therapeutic efficiency. These innovative agents utilize targeted delivery, imaging capabilities, and theranostic functionalities to optimize treatment outcomes. However, challenges remain in overcoming tumor heterogeneity, ensuring regulatory compliance, and scaling up production. This review provides a comprehensive analysis of current developments in boron delivery systems, offering insights into their potential to transform BNCT into a more effective and accessible cancer therapy.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses 生态友好的纳米颗粒植物合成通过植物提取物：机械的见解，最近的进展，和多方面的用途

Nano TransMed Pub Date : 2025-03-21 DOI: 10.1016/j.ntm.2025.100080

Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery

{"title":"Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses","authors":"Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery","doi":"10.1016/j.ntm.2025.100080","DOIUrl":"10.1016/j.ntm.2025.100080","url":null,"abstract":"<div><div>This review explores the phytosynthesis of nanoparticles (NPs) using plant extracts, emphasizing mechanistic insights, recent advancements, and their diverse applications. The green and cost-effective nature of phytosynthesis makes it an attractive alternative to conventional nanoparticle synthesis, with phytochemicals such as flavonoids, phenolics, and alkaloids facilitating metal ion reduction and stabilization. The review highlights key medical applications, including the anticancer potential of gold nanoparticles, which have demonstrated apoptosis induction in cancer cells, and their use in theranostic structures for simultaneous diagnosis and treatment. In environmental science, phytosynthesized iron and silver nanoparticles have shown over 90 % efficiency in heavy metal adsorption and pollutant degradation, contributing to sustainable remediation strategies. In agriculture, nanofertilizers synthesized via phytosynthesis have enhanced crop yields by up to 30 % while reducing chemical fertilizer dependence. Despite these advancements, obstacles persist in scaling up production, ensuring batch-to-batch reproducibility, and fully elucidating nanoparticle interactions at the molecular level. Standardizing synthesis protocols, optimizing plant metabolite compositions, and conducting extensive in vivo studies will be crucial in translating laboratory findings into real-world applications. By resolving these difficulties through interdisciplinary collaborations, phytosynthesized nanoparticles can revolutionize nanomedicine, agriculture, and environmental sustainability, paving the way for the next generation of eco-friendly technological innovations.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and recent progress of MXene-based bioactive materials in wound management mxeni基生物活性材料在伤口治疗中的应用及最新进展

Nano TransMed Pub Date : 2025-03-17 DOI: 10.1016/j.ntm.2025.100079

Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li

{"title":"Application and recent progress of MXene-based bioactive materials in wound management","authors":"Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li","doi":"10.1016/j.ntm.2025.100079","DOIUrl":"10.1016/j.ntm.2025.100079","url":null,"abstract":"<div><div>Wound management is one of the major challenges in the biomedical field, where wound ulceration and bacterial infections cause systemic inflammatory reactions or scarring in patients, seriously affecting the quality of life and causing great economic pressure. Smart bioactive materials offer new therapeutic strategies for wound management and monitoring, providing a tailored option for wound repair. MXene, as a 2D functional and tunable material, exhibits unique advantages and enormous potential in promoting cell growth, angiogenesis, recruiting immune cells, avoiding infections, and biological signal transmission. This review details the benefits of MXene-based materials in the field of tissue repair and addresses the key challenges faced by different wounds, reflecting excellent bioactivity and organismal suitability. Notably, MXene can function as a smart surrogate device, enabling precise assessments for wound monitoring and care. This development signifies a paradigm shift towards a novel era of non-invasive monitoring of the healing cycle. Nevertheless, strategies for regenerative tissue engineering employing MXene-based materials encounter certain challenges and difficulties, which include ensuring long-term bioactive function, developing novel material types, and meeting individual clinical needs. Finally, the future research directions and technological developments of MXene-based materials in wound management were briefly discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in electrochemical biosensors for bacterial detection 用于细菌检测的电化学生物传感器研究进展

Nano TransMed Pub Date : 2025-03-11 DOI: 10.1016/j.ntm.2025.100078

Yunyang Zhou , Qingcui Wang , Ting Xiang , Xiaohua Chen

{"title":"Recent advances in electrochemical biosensors for bacterial detection","authors":"Yunyang Zhou , Qingcui Wang , Ting Xiang , Xiaohua Chen","doi":"10.1016/j.ntm.2025.100078","DOIUrl":"10.1016/j.ntm.2025.100078","url":null,"abstract":"<div><div>Accurate and efficient bacterial detection remains a critical challenge in clinical diagnostics and public health. Conventional methods are often constrained by low sensitivity and labor-intensive workflows. In contrast, electrochemical sensors offer distinct advantages: high sensitivity, rapid response, cost-effectiveness, and ease of use. The advancement of electrochemical sensors for bacterial detection relies on the continuous optimization of fundamental sensing architectures and the integration of advanced technologies. This review adopts a dual foundation-to-frontier framework. Analyzing essential sensor components such as functional nanomaterials for interface engineering, precisely engineered biorecognition elements, and established electrochemical detection methodologies. Simultaneously, through an advanced technological lens, we explore cutting-edge interdisciplinary innovations such as dual-modal sensing systems, flexible sensor architectures, and artificial intelligence-driven analytical systems. By synthesizing foundational principles and technological innovations, this review not only informs rational sensor design but also delineates the transition toward miniaturized, intelligent, and high-throughput systems for precision medicine and environmental monitoring. This work aims to offer forward-looking guidance for the future development of bacterial detection technologies.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The delivery and transmembrane transport mechanism of SVCV nanovaccine SVCV纳米疫苗的传递和跨膜转运机制

Nano TransMed Pub Date : 2025-03-03 DOI: 10.1016/j.ntm.2025.100077

Han Zhang , Pan-pan Zhang , Xin-Xin Liu , Hai-hua Peng , Qun Liu , Jun Wang , Bin Zhu , Yong-Can Zhou , Yun Sun , Chen Zhang

{"title":"The delivery and transmembrane transport mechanism of SVCV nanovaccine","authors":"Han Zhang , Pan-pan Zhang , Xin-Xin Liu , Hai-hua Peng , Qun Liu , Jun Wang , Bin Zhu , Yong-Can Zhou , Yun Sun , Chen Zhang","doi":"10.1016/j.ntm.2025.100077","DOIUrl":"10.1016/j.ntm.2025.100077","url":null,"abstract":"<div><div>Spring viremia of carp virus (SVCV) is a fatal microorganism for a variety of cyprinid fish species, sparking off enormous economic losses in freshwater fish aquaculture. For alleviating losses, immersion vaccination is an extremely promising maneuver to prevent and curb on SVCV infection. In our previous research, we designed a modular immersion nanovaccine (LSG-TDH) targeting SVCV, and found that it could induce not merely mucosal immunity but systemic immune responses in zebrafish. Nevertheless, our previous research was unable to elaborate on how LSG-TDH were taken up by the cells. Thereby, this study aimed to investigate its transmembrane transport mechanism <em>in vitro</em> using epithelioma papulosum cyprini (EPC) cells and macrophages as models. The transmembrane transport mechanism of LSG-TDH on EPC cells and macrophages was analyzed by cell fluorescence, flow cytometry and chemical inhibitor experiments. The results showed that the entry of LSG-TDH into cells was time-dependent and energy-dependent. Chlorpromazine significantly inhibited the transmembrane transport of LSG-TDH. The contents of LSG-TDH into EPC cells and macrophages after treated with chlorpromazine decreased by 80 % and 71 %, respectively. It is indicated that the transmembrane transport of LSG-TDH was mainly achieved through clathrin-mediated endocytosis pathway. This study provides a reference for the delivery mechanism of aquatic nanovaccine, which has important scientific significance and application prospect.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation 利用纳米颗粒技术进行头颈癌的精准医疗：靶向递送、免疫调节和临床转化

Nano TransMed Pub Date : 2025-02-21 DOI: 10.1016/j.ntm.2025.100075

Karthikeyan Elumalai , Sivaneswari Srinivasan

{"title":"Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation","authors":"Karthikeyan Elumalai , Sivaneswari Srinivasan","doi":"10.1016/j.ntm.2025.100075","DOIUrl":"10.1016/j.ntm.2025.100075","url":null,"abstract":"<div><div>Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficiency and targeting. Researchers are studying different kinds of NPs, like liposomal, polymeric, dendritic, and gold nanoparticles (AuNPs), to see how they can improve drug delivery and change the tumour environment. To improve treatment results, we use specific strategies like targeting receptors, releasing substances inside cells in a controlled way, and adjusting the immune response. The review talks about how NPs focus on cancer-related fibroblasts, stop new blood vessel growth, and tackle problems in moving these treatments into real-world use. These issues include safety, toxicity, being able to produce them on a large scale, and following regulations. Finally, emerging trends, such as hybrid NPs and personalized nanomedicine, are proposed. Nanoparticle technology can greatly change how we treat head and neck cancer. It can improve how drugs are delivered, alter the environment around tumours, and tailor treatments to individual patients, which can make life better for them. This could lead to a new approach in cancer care.in cancer treatment.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-nanomaterials: Promising anticancer properties and treatment strategies 生物纳米材料：抗癌特性和治疗策略

Nano TransMed Pub Date : 2025-02-21 DOI: 10.1016/j.ntm.2025.100076

Elias Emeka Elemike , Innocent Chukwujekwu Onunkwo , Odiri Ughumiakpor , Faith Alawuru , Anthony Mukoro , Peter Ishom , Faith Obarakpor , Ismail Hossain , Andrew E. Aziza

{"title":"Bio-nanomaterials: Promising anticancer properties and treatment strategies","authors":"Elias Emeka Elemike , Innocent Chukwujekwu Onunkwo , Odiri Ughumiakpor , Faith Alawuru , Anthony Mukoro , Peter Ishom , Faith Obarakpor , Ismail Hossain , Andrew E. Aziza","doi":"10.1016/j.ntm.2025.100076","DOIUrl":"10.1016/j.ntm.2025.100076","url":null,"abstract":"<div><div>One of the most difficult diseases to treat in people is cancer, and its mortality rate has recently increased significantly. Nanoparticles are used in the rapidly developing field of cancer nanomedicine to diagnose and as well treat cancer. The often-systemic effects with conventional therapy have now been minimized by the ability of nanoparticles to release normally considered insoluble medicines to tumor locations both far and near. Due to their strong qualities and effects, which include biocompatibility, biosafety, biodegradability, synergistic and autologous therapeutic effects, biologically-based nanomaterials have drawn great interests with regards to cancer therapy. It has been extensively discussed and discovered that nucleic acid, polysaccharides, polyphenol or phenolics, proteins (also peptide), cell and subcellular fractions, as well as lipid are bioactive substances. The utilization of these biologically-active materials in nano-formulation is promising toward efficient treatment of cancer through by different oncological therapeutic strategies. As a result of their structural characterizations, adaptable characteristics, anti-tumor processes, and biological performances, these bioactive compounds have been specifically used as examples of the functions of composite nanosystems.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100076"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats 利用二氧化硅纳米颗粒嫁接抗坏血酸缓解大鼠氧化应激和脑活动受损

Nano TransMed Pub Date : 2025-01-28 DOI: 10.1016/j.ntm.2025.100074

Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Marwa Kechnebbou , Salem Amara

{"title":"Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats","authors":"Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Marwa Kechnebbou , Salem Amara","doi":"10.1016/j.ntm.2025.100074","DOIUrl":"10.1016/j.ntm.2025.100074","url":null,"abstract":"<div><div>The brain has natural antioxidant defense systems, functioning through enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase, which neutralize reactive oxygen species (ROS). Once these defense systems are overwhelmed by poisoning, oxidative damage can occur in the brain. In this study, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) was used to induce oxidative stress. Ascorbic acid grafted to silica nanoparticles (SiO<sub>2</sub>-NPs@AA) was used as a therapeutic strategy aimed to reduce ROS levels and enhancing antioxidant defenses. The SiO<sub>2</sub>-NPs@AA were synthesized and characterized, showing efficient functionalization with ascorbic acid. The in-vitro, antioxidant assays revealed that SiO<sub>2</sub>-NPs@AA exhibited significant radical scavenging activity (DPPH and hydroxyl radicals) and high iron-chelating ability with enhanced stability compared to free ascorbic acid. Moreover, the in-vivo study demonstrated that SiO<sub>2</sub>-NPs@AA mitigated H<sub>2</sub>O<sub>2</sub>-induced effects in key enzymes, including superoxide dismutase, catalase, glutathione (GSH), and restore acetylcholinesterase (AChE) levels. Notably, malondialdehyde (MDA) levels, a marker of lipid peroxidation, were significantly reestablished in the frontal cortex and hippocampus following SiO<sub>2</sub>-NPs@AA. Overall, the study revealed that SiO<sub>2</sub>-NPs@AA corrected effectively nitric oxide (NO) and monoamine oxidase activities, which confirm their role to preserve neuronal function and mitigate neurotoxicity.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0