Nano TransMed最新文献

{"title":"Corrigendum to “SNEDDS delivery of black sticky rice extract: Hepatoprotective and antioxidant potential” [Nano TransMed 5 (2026) 100111]","authors":"Anggun Hari Kusumawati , Elfahmi Elfahmi , Afrillia Nuryanti Garmana , Rachmat Mauludin","doi":"10.1016/j.ntm.2026.100114","DOIUrl":"10.1016/j.ntm.2026.100114","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SNEDDS delivery of black sticky rice extract: Hepatoprotective and antioxidant potential","authors":"Anggun Hari Kusumawati ,&nbsp;Elfahmi Elfahmi ,&nbsp;Afrillia Nuryanti Garmana ,&nbsp;Rachmat Mauludin","doi":"10.1016/j.ntm.2025.100111","DOIUrl":"10.1016/j.ntm.2025.100111","url":null,"abstract":"<div><div>Black sticky rice (<em>Oryza sativa</em> var. <em>glutinosa</em> Blanco) Extract (BSRE) contains a high concentration of polyphenols, flavonoids, and anthocyanins with known antioxidant and hepatoprotective effects. Nevertheless, its clinical application is limited by poor water solubility and low bioavailability. This study is intended to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) formulations of BSRE to enhance its antioxidant and hepatoprotective effects. The systems are characterized for their physicochemical properties and evaluated <em>in vitro</em> and <em>in vivo</em> in carbon tetrachloride (CCl₄)-induced liver damage in rats. Ethanolic maceration extraction was performed, followed by phytochemical and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS)/MS fingerprinting. SNEDDS was formulated with corn oil, Tween 80, and propylene glycol and optimized through pseudo-ternary phase diagrams. The optimized system was then adsorbed onto Neusilin® US2 to produce S-SNEDDS. Both systems were characterized for droplet size, emulsification time, zeta potential, and thermodynamic stability. Dissolution and antioxidant activity (DPPH assay) were measured <em>in vitro</em>, while <em>in vivo</em> efficacy was tested in the CCl₄-induced hepatotoxicity rat model. BSRE was found to have high cyanidin-3-O-glucoside (13.87 ± 0.12 mg/g) and quercetin (24.10 ± 1.34 mg/g) content. SNEDDS produced nano-sized droplets (∼15 nm) with fast emulsification and enhanced solubility at pH 1.2, 4.5, and 6.8. Antioxidant activity was markedly improved in SNEDDS-BSRE (IC₅₀: 32.6 µg/mL) compared to crude BSRE (IC₅₀: 47.4 µg/mL). SNEDDS-BSRE at 100 and 200 mg/kg body weight (BW) significantly lowered serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT), alkaline phosphatase (ALP), and bilirubin (BIL) and normalized albumin (ALB) level. Histopathological analysis confirmed reduced hepatic necrosis and inflammation. This investigation illustrates that SNEDDS-based delivery system profoundly improves the physicochemical stability, antioxidant activity, and hepatoprotective effect of BSRE, favoring its development as a functional nutraceutical. Additional pharmacokinetic and clinical studies are necessary to establish its translational feasibility.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic activity of photoactivated curcumin-derived nanocomplexes in combination with antibiotics against planktonic and biofilm bacterial cells","authors":"Humberto Antonio Salazar-Sesatty ,&nbsp;Edeer Iván Montoya-Hinojosa ,&nbsp;Luis D. Terrazas-Armendariz ,&nbsp;Cynthia A. Alvizo-Baez ,&nbsp;Daniel Salas-Treviño ,&nbsp;Paola Bocanegra-Ibarias ,&nbsp;Adrián Camacho-Ortiz ,&nbsp;Itza E. Luna-Cruz ,&nbsp;Juan M. Alcocer-González ,&nbsp;Samantha Flores-Treviño","doi":"10.1016/j.ntm.2025.100110","DOIUrl":"10.1016/j.ntm.2025.100110","url":null,"abstract":"<div><h3>Background</h3><div>Alternative antimicrobial strategies such as antimicrobial photodynamic therapy (aPDT) and curcumin-derived nanocomplexes were assessed in this study against biofilm cells of Gram-positive and Gram-negative clinical isolates.</div></div><div><h3>Methods</h3><div>Curcumin-derived nanocomplexes (curcumin-chitosan magnetic nanoparticles [Cur-Chi-MNPs], carbon magnetic-nanoparticles [Cur-C-MNPs] and Curcumin-derived carbon quantum dots [Cur-QDs] were synthetized and characterized using scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and dynamic light scattering. The antimicrobial activity of photoactivated curcumin-derived nanocomplexes after blue light (400 −470 nm), green light (495 −570 nm), and red light (620 −750 nm) exposure was assessed on biofilm bacterial cells of clinical isolates of Gram-negative and Gram-positive bacteria.</div></div><div><h3>Results</h3><div>Photoactivation of curcumin by green, red light and blue light increased the antibiofilm activity against Gram-positive isolates and Gram-negative isolates, but the effect was higher in Gram-positive pathogens. Green light photoactivation of Cur-Chi-MNPs and Cur-QDs yielded antibiofilm activity against <em>Staphylococcus lugdunensis</em>, whilst Cur-C-MNPs showed antibiofilm activity only against <em>Stenotrophomonas maltophilia</em> regardless of photoactivation.</div></div><div><h3>Conclusions</h3><div>Photoactivated curcumin-derived nanocomplexes showed antimicrobial and antibiofilm properties against some Gram-positive and Gram-negative bacterial strains. Nanocurcumin-mediated aPDT could be a potential treatment option for biofilm eradication of clinical drug-resistant infections.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation injectable hydrogels: Advanced crosslinking strategies, multi-stimuli responsiveness, and translational advances for precision regenerative medicine","authors":"Govindaraj Sabarees,&nbsp;Yobu Sam Jebaraj,&nbsp;Elumalai Ezhilarasan,&nbsp;Yuvaraj Dravid Ragul","doi":"10.1016/j.ntm.2025.100109","DOIUrl":"10.1016/j.ntm.2025.100109","url":null,"abstract":"<div><div>Injectable hydrogels represent a transformative platform in biomaterials, enabling minimally invasive delivery and precise therapeutic localization with biomimetic structural and functional properties. Recent innovations in chemistry and crosslinking ranging from photopolymerization, click chemistry, and Schiff’s base formation to enzyme-mediated catalysis and supramolecular assemblies allow finely tuned gelation kinetics, mechanical strength, degradation, and responsive bioactivity under physiological conditions. This comprehensive review systematically examines next-generation injectable hydrogels, highlighting chemical and physical crosslinking mechanisms and integration of multi-stimuli responsiveness including temperature, pH, light, and enzymatic triggers to achieve spatiotemporal control of tissue regeneration and drug delivery. We critically evaluate translational advances across diverse tissue engineering domains such as bone, cartilage, cardiac, neural, skin, liver, pancreas, vascular, and periodontal tissues. Challenges in scalability, reproducibility, sterilization, and regulatory approval remain, yet ongoing progress in biofunctionalization and injectable biofabrication underpins their promise for personalized regenerative medicine. Bridging fundamental materials science and clinical translation, injectable hydrogels are poised to revolutionize minimally invasive therapies and precision medicine in the decade ahead.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-mediated cardiotoxicity and nanomedicine interventions in cancer treatment","authors":"Emmanuel O. Oisakede ,&nbsp;Olawunmi O. Oyedeji ,&nbsp;Olabanke Florence Olawuyi ,&nbsp;John Oluwatosin Alabi ,&nbsp;Raphael Igbarumah Ayo Daniel ,&nbsp;David B. Olawade","doi":"10.1016/j.ntm.2026.100113","DOIUrl":"10.1016/j.ntm.2026.100113","url":null,"abstract":"<div><div>Nanoparticle-based therapies have emerged as transformative tools in oncology, offering targeted drug delivery, improved pharmacokinetics, and minimised systemic toxicity. However, accumulating evidence suggests that whilst nanomedicines enhance therapeutic efficacy, they may inadvertently induce cardiotoxic effects through mechanisms including oxidative stress, mitochondrial dysfunction, immune activation, endothelial injury, and off-target accumulation in cardiac tissues. This narrative review synthesises current literature on the cardiotoxic potential of various nanoparticle classes, including liposomes, polymeric nanoparticles, metallic nanostructures, dendrimers, and carbon-based materials. Following an established narrative review framework, we examined how nanoparticle physicochemical properties, administration parameters, and patient-specific factors contribute to cardiac risks, evaluated current and emerging methodologies for detecting nanoparticle-induced cardiotoxicity, and explored mitigation strategies through nanomedicine design innovations and artificial intelligence integration. The assessment of nanoparticle-induced cardiotoxicity faces significant challenges, including absent standardised evaluation protocols, limited sensitivity of traditional diagnostic tools, and difficulties isolating nanoparticle-specific effects from concurrent cancer therapies. Promising solutions encompass advanced in vitro cardiac models (organoids, heart-on-a-chip), novel biomarkers (microRNAs, extracellular vesicles), molecular imaging technologies, and computational modelling. Preventative strategies involve surface modification, biodegradable or biomimetic materials, co-delivery of cardioprotective agents, and stimuli-responsive drug delivery systems. Artificial intelligence is enhancing nanoparticle design optimisation, toxicity prediction, and personalised monitoring through digital twin models and AI-assisted imaging. As nanomedicine advances cancer care, addressing cardiotoxic risks through interdisciplinary collaboration, improved regulatory frameworks, and precision cardio-oncology strategies is imperative for ensuring safe, effective nanoparticle use in cancer treatment.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin poly D-L lactide nanoparticles demonstrate superior antiplasmodial Efficacy and multi-target binding compared with dihydroartemisinin: Integrative in vivo and in silico analyses","authors":"Olorunfemi Abraham Eseyin ,&nbsp;Aniekan Stephen Ebong ,&nbsp;Ekarika Clement Johnson ,&nbsp;Emmanuel Olorunsola ,&nbsp;Imaobong Etti ,&nbsp;Grace Essien ,&nbsp;Johnny Imoh ,&nbsp;Ekaete Akpabio ,&nbsp;Emmanuel I. Etim ,&nbsp;Grace Effiong ,&nbsp;Sheryar Afzal","doi":"10.1016/j.ntm.2025.100112","DOIUrl":"10.1016/j.ntm.2025.100112","url":null,"abstract":"<div><h3>Background</h3><div>The urgent rise of drug-resistant malaria underscores the need for innovative antimalarial agents with multi-targeting capabilities. Curcumin, a polyphenolic compound derived from turmeric, is known for its extensive pharmacological properties; however, its low bioavailability hinders its clinical application. This study compared the antiplasmodial activity, safety profile, and multitarget binding potential of curcumin and its nanoparticle formulations with those of dihydroartemisinin (DHA).</div></div><div><h3>Methods</h3><div>Curcumin nanoparticles were produced using a modified emulsion-solvent evaporation technique and were characterized through Fourier-transform infrared spectroscopy (FTIR) and dynamic light scattering methods. Acute oral toxicity assessments were conducted in mice following the OECD Guideline 423. Swiss albino mice infected with <em>P. berghei</em> NK-65 were treated with varying doses of curcumin, nanocurcumin, DHA, or distilled water. The parasitemia level was evaluated using Giemsa-stained blood smears. Additionally, molecular docking studies were conducted using AutoDock Vina to target key proteins of <em>P. falciparum</em>, with the visualisation of protein-ligand interactions carried out in Discovery Studio.</div></div><div><h3>Results</h3><div>Both curcumin and nanocurcumin exhibited a dose-dependent increase in parasite clearance, significantly surpassing DHA. Notably, nanocurcumin at lower doses achieved over 90 % reduction in parasitemia. Acute toxicity evaluation indicated no fatalities or severe adverse effects at doses up to 5000 mg/kg. Curcumin exhibited superior binding affinities and more comprehensive interactions with various parasite targets compared with DHA.</div></div><div><h3>Conclusion</h3><div>Curcumin, especially in its nanoparticle form, displays potent multi-target antiplasmodial activity and a favourable safety profile in mice, outperforming DHA. These findings advocate for the continued development of curcumin-based therapeutic strategies for malaria, particularly against strains exhibiting drug resistance.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mini-review on the multimodal applications of engineered magnetic nanoparticles in diagnosis and therapy","authors":"Jagabandhu Bag ,&nbsp;Rudradeep Hazra ,&nbsp;Rupam Mahish ,&nbsp;Avijit Kumar Dey ,&nbsp;Dishani Sukul ,&nbsp;Ashok Kumar S K ,&nbsp;Sourav De","doi":"10.1016/j.ntm.2025.100100","DOIUrl":"10.1016/j.ntm.2025.100100","url":null,"abstract":"<div><div>The magnetic nanoparticles (MNPs) have emerged as multifunctional tools in recent medicine by virtue of their tunable size, larger surface area, and characteristic magnetic properties. Engineered MNPs have been well investigated in the recent two decades for diagnostic imaging, targeted drug delivery, hyperthermia, and multifunctional therapeutic applications. Their efficacy is profoundly dependent on controlled synthesis, surface functionalization, and biocompatibility, significantly influencing stability, biodistribution, and clinical efficacy. Recent work demonstrates their potential for imaging sensitivity enhancement, precise drug targeting, and therapeutic efficacy improvement through multifunctional integration of diagnostic and therapeutic functions. Despite aggregation, toxicity, and scalability challenges, continuous innovation in synthesis methodology and surface engineering is enhancing their translational potential. This review provides current developments in the design and biomedical applications of engineered MNPs, which emphasize their value in promoting personalized medicine and theranostics. Ultimately, MNPs are a revolutionary platform that integrates diagnosis and therapy, opening up new avenues toward effective and minimally invasive patient care.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Platelet lysate promotes proliferation and angiogenic activity of dental pulp stem cells via store-operated Ca2+ entry” [Nano TransMed 2 (2023) 100021]","authors":"Xiangyan Liao ,&nbsp;Min Chen ,&nbsp;Yuan Zhang ,&nbsp;Shengcun Li ,&nbsp;Yejian Li ,&nbsp;Yan He ,&nbsp;Yanteng Zhao ,&nbsp;Lihua Luo","doi":"10.1016/j.ntm.2025.100094","DOIUrl":"10.1016/j.ntm.2025.100094","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposome-encapsulated therapies: Precision medicine for inflammatory lung disorders","authors":"Mohammad Arshad Javed Shaikh ,&nbsp;Kavita Goyal ,&nbsp;Muhammad Afzal ,&nbsp;R. Roopashree ,&nbsp;Mukesh Kumari ,&nbsp;T. Krithiga ,&nbsp;Rajashree Panigrahi ,&nbsp;Suman Saini ,&nbsp;Haider Ali ,&nbsp;Mohd Imran ,&nbsp;Abida ,&nbsp;Tarun Patodia ,&nbsp;Gaurav Gupta","doi":"10.1016/j.ntm.2025.100082","DOIUrl":"10.1016/j.ntm.2025.100082","url":null,"abstract":"<div><div>Liposomes have emerged as the preferred choice over other nanocomposites for transporting a wide range of hydrophobic and hydrophilic compounds with therapeutic potential. This is primarily due to their exceptional degradation ability, compatibility within biological systems, and minimal immunogenicity. Liposomes have demonstrated their ability to enhance the solubility and distribution of medications. Moreover, they can undergo surface modifications to enable sustained, prolonged, and targeted release. Inflammatory lung disorders such as asthma, lung cancer, lung damage, tuberculosis, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) greatly benefit from liposomes' unique treatment and management qualities. This article provides an overview of the current understanding of liposomal systems' efficacy in drug delivery for managing pulmonary inflammatory diseases.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression [Nano TransMed 3C (2024) 100049]","authors":"Vinotha Mani ,&nbsp;Keerthana Shrri Gopinath ,&nbsp;Nithya Varadharaju ,&nbsp;Dapkupar Wankhar ,&nbsp;Arjunan Annavi","doi":"10.1016/j.ntm.2025.100098","DOIUrl":"10.1016/j.ntm.2025.100098","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}