生物纳米材料:抗癌特性和治疗策略

Elias Emeka Elemike , Innocent Chukwujekwu Onunkwo , Odiri Ughumiakpor , Faith Alawuru , Anthony Mukoro , Peter Ishom , Faith Obarakpor , Ismail Hossain , Andrew E. Aziza
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引用次数: 0

摘要

癌症是人类最难治疗的疾病之一,其死亡率最近显著上升。纳米粒子被用于快速发展的癌症纳米医学领域,用于诊断和治疗癌症。由于纳米颗粒能够将通常被认为不溶性的药物释放到肿瘤的远近部位,传统疗法的全身效应现在已经降到最低。由于生物基纳米材料具有生物相容性、生物安全性、生物可降解性、协同性和自体治疗效应等优良特性和效果,在癌症治疗方面引起了人们极大的兴趣。核酸、多糖、多酚或酚类物质、蛋白质(也包括肽)、细胞和亚细胞组分以及脂质都是生物活性物质,已被广泛讨论和发现。这些生物活性物质在纳米制剂中的应用有望通过不同的肿瘤治疗策略来有效地治疗癌症。由于其结构特征、适应性特征、抗肿瘤过程和生物学性能,这些生物活性化合物已被专门用作复合纳米系统功能的例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bio-nanomaterials: Promising anticancer properties and treatment strategies
One of the most difficult diseases to treat in people is cancer, and its mortality rate has recently increased significantly. Nanoparticles are used in the rapidly developing field of cancer nanomedicine to diagnose and as well treat cancer. The often-systemic effects with conventional therapy have now been minimized by the ability of nanoparticles to release normally considered insoluble medicines to tumor locations both far and near. Due to their strong qualities and effects, which include biocompatibility, biosafety, biodegradability, synergistic and autologous therapeutic effects, biologically-based nanomaterials have drawn great interests with regards to cancer therapy. It has been extensively discussed and discovered that nucleic acid, polysaccharides, polyphenol or phenolics, proteins (also peptide), cell and subcellular fractions, as well as lipid are bioactive substances. The utilization of these biologically-active materials in nano-formulation is promising toward efficient treatment of cancer through by different oncological therapeutic strategies. As a result of their structural characterizations, adaptable characteristics, anti-tumor processes, and biological performances, these bioactive compounds have been specifically used as examples of the functions of composite nanosystems.
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