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Current challenges and potential directions towards nanotechnology in medicine and transformation 纳米技术在医学和转化中的当前挑战和潜在方向
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130011
Qianqian Ni , Xiaoyuan Chen
{"title":"Current challenges and potential directions towards nanotechnology in medicine and transformation","authors":"Qianqian Ni , Xiaoyuan Chen","doi":"10.26599/NTM.2022.9130011","DOIUrl":"10.26599/NTM.2022.9130011","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130011"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88040318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the organic semiconducting photosensitizers for hypoxia-tolerant type I photodynamic therapy 有机半导体光敏剂在耐缺氧I型光动力治疗中的应用
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130010
Xiaoming Hu , Caijun Zhu , Fengwei Sun , Jin Yang , Zejing Chen , Haiyong Ao , Cao Cui , Zhen Yang , Wei Huang
{"title":"Insights into the organic semiconducting photosensitizers for hypoxia-tolerant type I photodynamic therapy","authors":"Xiaoming Hu ,&nbsp;Caijun Zhu ,&nbsp;Fengwei Sun ,&nbsp;Jin Yang ,&nbsp;Zejing Chen ,&nbsp;Haiyong Ao ,&nbsp;Cao Cui ,&nbsp;Zhen Yang ,&nbsp;Wei Huang","doi":"10.26599/NTM.2022.9130010","DOIUrl":"10.26599/NTM.2022.9130010","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a promising approach to treat cancer and microbial infections due to its minimal invasiveness, high spatiotemporal selectivity, tissue specificity, and low toxicity. Depending on the reactive oxygen species generation mechanisms, PDT can be classified as type I and type II. To date, most reported photosensitizers are based on the type II PDT mechanism, which produces toxic singlet oxygen and requires an abundant and continuous supply of oxygen molecules. Unfortunately, in typical solid tumor microenvironments, vascular abnormalities and rapid metabolisms lead to oxygen deficiency, severely compromising type II PDT's effectiveness. To address this issue, type I PDT with less oxygen consumption has been developed as an effective way to overcome the limitations of traditional type II PDT. In this contribution, we focus on the recent advances in type I organic semiconducting photosensitizers (OSPs), including organic semiconducting small molecules, conjugated polymers, and covalent organic frameworks for advanced hypoxia-tolerant PDT. The conceptual framework and general properties of these OSPs are firstly introduced, followed by introducing OSPs with different chemical structures for type I PDT. Finally, the overall conclusion, insightful perspective, and future direction of the efforts of OSPs for advanced biological applications are outlined.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130010"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82478182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A success story in these challenging times 在这个充满挑战的时代，这是一个成功的故事
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130012
Andrew Sandham , Qingsong Ye
{"title":"A success story in these challenging times","authors":"Andrew Sandham ,&nbsp;Qingsong Ye","doi":"10.26599/NTM.2022.9130012","DOIUrl":"10.26599/NTM.2022.9130012","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130012"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78821111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of telomere biology and telomerase in mesenchymal stem cells 端粒生物学和端粒酶在间充质干细胞中的应用
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130007
Shuili Jing , Heng Zhou , Chen Zou , David P.C. Chen , Qingsong Ye , Yilong Ai , Yan He
{"title":"Application of telomere biology and telomerase in mesenchymal stem cells","authors":"Shuili Jing ,&nbsp;Heng Zhou ,&nbsp;Chen Zou ,&nbsp;David P.C. Chen ,&nbsp;Qingsong Ye ,&nbsp;Yilong Ai ,&nbsp;Yan He","doi":"10.26599/NTM.2022.9130007","DOIUrl":"10.26599/NTM.2022.9130007","url":null,"abstract":"<div><div>With the increasing understanding of mesenchymal stem cells (MSCs), their potential in tissue engineering and regenerative medicine has attracted more attention. However, some important problems need to be solved before clinical application, such as low amplification efficiency, inconsistent cell product quality, and unsatisfactory survival rate at the receptor site. Telomeres act as a clock, and they shorten when cells divide. The main mechanism for reversing telomere length is telomerase. Furthermore, telomerase is involved in antioxidation, antiapoptosis, immunological modulation, and other noncanonical processes in addition to proliferation-related tasks. Therefore, it is necessary to understand the telomere biology and telomerase of MSCs to improve their proliferation, performance stability, and antiscavenging ability. This review summarizes the progress of telomerase biological function and mechanism in MSCs, and discusses the current situation and deficiency of telomerase-related application in MSCs.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130007"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77737534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetically precipitated nanocrystalline hydroxyapatite 仿生沉淀的纳米羟基磷灰石
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130008
Ben Wan , Yan Ruan , Chenxi Shen , Gaoli Xu , Tymour Forouzanfar , Haiyan Lin , Gang Wu
{"title":"Biomimetically precipitated nanocrystalline hydroxyapatite","authors":"Ben Wan ,&nbsp;Yan Ruan ,&nbsp;Chenxi Shen ,&nbsp;Gaoli Xu ,&nbsp;Tymour Forouzanfar ,&nbsp;Haiyan Lin ,&nbsp;Gang Wu","doi":"10.26599/NTM.2022.9130008","DOIUrl":"10.26599/NTM.2022.9130008","url":null,"abstract":"<div><div>Nanocrystalline hydroxyapatite has been extensively used for biomedical field, such as drug carrier, antitumor agent, surface coating, and bone-regenerating material. The wet chemical method is one of the most commonly used methods in the synthesis of nanosized hydroxyapatite due to its relatively low costs and more customizable control of the final product. Herein, we updated the most recent advances in artificial nano-hydroxyapatite prepared from biomimetic precipitation throughout context. Furthermore, micron-sized particles and macro-sized scaffolds made of nano-hydroxyapatite deposition are introduced. Their outstanding physicochemical properties and potential clinical application are highlighted. This article reviews the latest progress on preparing biomimetic nano-hydroxyapatite and provides inspiration to promote new breakthrough in regenerative therapy and clinical translation.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130008"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77481574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in macrophage-derived exosomes as delivery vehicles 巨噬细胞来源外泌体作为递送载体的最新进展
Nano TransMed Pub Date : 2022-12-01 DOI: 10.26599/NTM.2022.9130013
Shumin Wang , Yajie Yang , Shenhua Li , Haibo Chen , Yongsheng Zhao , Jing Mu
{"title":"Recent advances in macrophage-derived exosomes as delivery vehicles","authors":"Shumin Wang ,&nbsp;Yajie Yang ,&nbsp;Shenhua Li ,&nbsp;Haibo Chen ,&nbsp;Yongsheng Zhao ,&nbsp;Jing Mu","doi":"10.26599/NTM.2022.9130013","DOIUrl":"10.26599/NTM.2022.9130013","url":null,"abstract":"<div><div>Macrophages are important members of the innate immune system that can be reversibly polarized by different microenvironment signals. Exosomes secreted from cells are lipid bilayer membrane vesicles carrying versatile biomolecules, which displays unique properties and biological functions. Recent studies have shown that macrophage derived exosomes as an extracellular vehicle can deliver diverse cargoes including small molecules, nanoparticles, and biological macromolecules to recipient cells, and thus affect the progression of cancers and other diseases. Moreover, exosomes secreted by different phenotypes of macrophages provide different therapeutic options. Thus, in this review, we summarized recent progress in the macrophage derived exosomes as carriers for delivering different types of cargos. Then the engineering principles and their applications are elaborated. In the end, challenges and prospects of macrophage derived exosomes for drug delivery and disease treatment are also discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130013"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75301664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The era of translational nanomedicine 转化纳米医学的时代
Nano TransMed Pub Date : 2022-03-01 DOI: 10.26599/NTM.2022.9130006
Qingsong Ye , Yu Shrike Zhang
{"title":"The era of translational nanomedicine","authors":"Qingsong Ye ,&nbsp;Yu Shrike Zhang","doi":"10.26599/NTM.2022.9130006","DOIUrl":"10.26599/NTM.2022.9130006","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 1","pages":"Article e9130006"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89756240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in porous inorganic nanomaterials for bone regeneration 骨再生用多孔无机纳米材料的研究进展
Nano TransMed Pub Date : 2022-03-01 DOI: 10.26599/NTM.2022.9130005
Huan Dai , Sepanta Hosseinpour , Shu Hua , Chun Xu
{"title":"Advances in porous inorganic nanomaterials for bone regeneration","authors":"Huan Dai ,&nbsp;Sepanta Hosseinpour ,&nbsp;Shu Hua ,&nbsp;Chun Xu","doi":"10.26599/NTM.2022.9130005","DOIUrl":"10.26599/NTM.2022.9130005","url":null,"abstract":"<div><div>Porous inorganic materials such as mesoporous silica nanoparticles (MSNs), mesoporous bioactive glasses (MBGs), porous calcium phosphates, and metal-organic frameworks (MOFs) are used for bone regeneration due to their osteoinductive and porous properties. The direct osteogenesis ability can be adjusted by the design and composition of those inorganic materials. With porous structure, adjustable pore size and high surface area, they are used as carriers to deliver various small molecular drugs, proteins, and genes locally to promote bone generation. The surface of those porous inorganic materials can be further functionalized to control the loading and release of drugs and modulate the behaviour of host cells. This review summarizes the recent advances of various porous inorganic nanomaterials for bone repairing with a focus on their performance as scaffolds and drug delivery systems. We also discuss the challenges and prospects of porous inorganic nanomaterials for the future clinical application for bone regeneration.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 1","pages":"Article e9130005"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87964666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin biomechanics: Breaking the dermal barriers with microneedles 皮肤生物力学：用微针打破真皮屏障
Nano TransMed Pub Date : 2022-03-01 DOI: 10.26599/NTM.2022.9130002
Masood Ali , Sarika Namjoshi , Heather A.E. Benson , Tushar Kumeria , Yousuf Mohammed
{"title":"Skin biomechanics: Breaking the dermal barriers with microneedles","authors":"Masood Ali ,&nbsp;Sarika Namjoshi ,&nbsp;Heather A.E. Benson ,&nbsp;Tushar Kumeria ,&nbsp;Yousuf Mohammed","doi":"10.26599/NTM.2022.9130002","DOIUrl":"10.26599/NTM.2022.9130002","url":null,"abstract":"<div><div>Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review, we discuss both the anatomical features and biomechanical properties of skin in order to understand the local environment and resistive forces relevant to μNDs insertion. Of particular importance are the factors that affect μND insertion, such as their geometry and material composition, as these can be manipulated in the design and development phase to optimise skin insertion. We review the research relevant to μND and how this interacts with skin properties. We have also reviewed the most commonly used skin drug diffusion modelling used to predict drug behaviour from μNDs, and discussed the current challenges faced by μNDs to enter clinical trials and provide positive clinical outcomes.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 1","pages":"Article e9130002"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80037481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evoking pyroptosis with nanomaterials for cancer immunotherapy: Current boom and novel outlook 纳米材料在肿瘤免疫治疗中的应用：现状与展望
Nano TransMed Pub Date : 2022-03-01 DOI: 10.26599/NTM.2022.9130001
Wen-Da Wang , Zhi-Jun Sun
{"title":"Evoking pyroptosis with nanomaterials for cancer immunotherapy: Current boom and novel outlook","authors":"Wen-Da Wang ,&nbsp;Zhi-Jun Sun","doi":"10.26599/NTM.2022.9130001","DOIUrl":"10.26599/NTM.2022.9130001","url":null,"abstract":"<div><h3>ABSTRACT</h3><div>Cancer immunotherapy, including immune checkpoint blockade, has emerged as a powerful and effective clinical strategy for the treatment of tumors. However, the low response rates or systemic adverse effects owing to the heterogeneity of the tumor microenvironment limit the efficacy of cancer immunotherapy. Pyroptosis, featuring inflammation and lysis, can promote the release of large amounts of proinflammatory agents that reprogram the tumor microenvironment and is expected to achieve the transition from “cold” tumors to “hot” tumors. Therefore, understanding how to particularly evoke tumor cell pyroptosis is crucial in overcoming the adverse effects associated with the tumor microenvironment. The development of emerging nanotechnology offers an avenue for tumor-targeted drug development. Nanomaterials that can trigger tumor-specific pyroptosis have promising applications in improving the efficacy of cancer immunotherapy while reducing systemic adverse effects. Herein, we review the fundamentals of pyroptosis, and summarize the strategies of pyroptosis-based nanomaterials that have been developed recently, with emphasis on their utility and benefits in cancer immunotherapy. Furthermore, we put forth our viewpoints regarding the investigation of nanomaterials and suggest future directions for this rapidly developing field.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 1","pages":"Article e9130001"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78678655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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