巨噬细胞来源外泌体作为递送载体的最新进展

Shumin Wang , Yajie Yang , Shenhua Li , Haibo Chen , Yongsheng Zhao , Jing Mu
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引用次数: 0

摘要

巨噬细胞是先天免疫系统的重要成员,可以被不同的微环境信号可逆地极化。细胞分泌的外泌体是携带多种生物分子的脂质双层膜囊,具有独特的性质和生物学功能。最近的研究表明,巨噬细胞衍生的外泌体作为细胞外载体可以向受体细胞递送包括小分子、纳米颗粒和生物大分子在内的多种货物,从而影响癌症和其他疾病的进展。此外,不同表型巨噬细胞分泌的外泌体提供了不同的治疗选择。因此,在这篇综述中,我们总结了巨噬细胞衍生的外泌体作为运送不同类型货物的载体的最新进展。然后阐述了工程原理及其应用。最后,讨论了巨噬细胞来源的外泌体在药物传递和疾病治疗中的挑战和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in macrophage-derived exosomes as delivery vehicles
Macrophages are important members of the innate immune system that can be reversibly polarized by different microenvironment signals. Exosomes secreted from cells are lipid bilayer membrane vesicles carrying versatile biomolecules, which displays unique properties and biological functions. Recent studies have shown that macrophage derived exosomes as an extracellular vehicle can deliver diverse cargoes including small molecules, nanoparticles, and biological macromolecules to recipient cells, and thus affect the progression of cancers and other diseases. Moreover, exosomes secreted by different phenotypes of macrophages provide different therapeutic options. Thus, in this review, we summarized recent progress in the macrophage derived exosomes as carriers for delivering different types of cargos. Then the engineering principles and their applications are elaborated. In the end, challenges and prospects of macrophage derived exosomes for drug delivery and disease treatment are also discussed.
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