发布求助
文献互助 智能选刊 最新文献

Medicine - Programa de Formación Médica Continuada Acreditado最新文献

筛选
英文 中文
Trombosis en el paciente con cáncer
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.02.007
P. Freijido-Álvarez, N. González-García, N. Fernández-Díaz, J. Ruíz-Bañobre, C. Fernández-Reino, L. León-Mateos, U. Anido-Herranz, R. López-López
{"title":"Trombosis en el paciente con cáncer","authors":"P. Freijido-Álvarez,&nbsp;N. González-García,&nbsp;N. Fernández-Díaz,&nbsp;J. Ruíz-Bañobre,&nbsp;C. Fernández-Reino,&nbsp;L. León-Mateos,&nbsp;U. Anido-Herranz,&nbsp;R. López-López","doi":"10.1016/j.med.2025.02.007","DOIUrl":"10.1016/j.med.2025.02.007","url":null,"abstract":"<div><div>Oncological diseases significantly increase the risk of thrombosis, which is especially high in certain types of cancer (pancreatic, gastric, cerebral) and therapies (cisplatin, tamoxifen, antiangiogenic drugs). Antithrombotic prophylaxis in oncology patients depends on individual risk and may include both low-molecular-weight heparins and oral anticoagulants (individualized according to patient characteristics). Hospitalized patients who are immobile should receive prophylaxis if they are not at high risk of bleeding. For major surgeries, prophylaxis is started 12<!--> <!-->hours afterwards and can be extended up to four weeks. In outpatients, the Khorana score is used to assess risk. The duration of treatment varies (in general it is maintained for at least six months) and, in cases of recurrence, the dosage is adjusted or the type of anticoagulant is changed. Catheter-associated thrombosis requires anticoagulation, avoiding catheter removal if the catheter is functioning and not infected</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 26","pages":"Pages 1562-1565"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumores germinales
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.02.003
M. Giráldez-Martínez, N. Fernández-Díaz, N. González-García, C. Fernández-Reino, U. Anido-Herranz, J. Ruíz-Bañobre, L. León-Mateos, R. López-López
{"title":"Tumores germinales","authors":"M. Giráldez-Martínez,&nbsp;N. Fernández-Díaz,&nbsp;N. González-García,&nbsp;C. Fernández-Reino,&nbsp;U. Anido-Herranz,&nbsp;J. Ruíz-Bañobre,&nbsp;L. León-Mateos,&nbsp;R. López-López","doi":"10.1016/j.med.2025.02.003","DOIUrl":"10.1016/j.med.2025.02.003","url":null,"abstract":"<div><div>Germ cell tumors are a heterogeneous group of neoplasms that originate from germ cells, the precursor cells of the gametes. These tumors can occur in various anatomical locations, both in the gonads (testes and ovaries) and in extragonadal sites (mediastinum, retroperitoneum, and central nervous system). The etiopathogenesis of germ cell tumors involves a combination of genetic and environmental factors. They are classified into two main categories: seminomatous and nonseminomatous germ cell tumors, each with specific subtypes. This text addresses the predisposing factors, classification, natural history, forms of onset, patterns of progression, complications, special situations, diagnosis, staging, and treatment of germ cell tumors. The aim of this analysis is to provide a comprehensive vision that facilitates the understanding of these tumors and the optimization of therapeutic strategies.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 26","pages":"Pages 1534-1540"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocolo diagnóstico y terapéutico de la sarcopenia en los tumores gastrointestinales
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.018
M. Cruz Gómez , A. Villalba Yllán , M.J. Rodríguez Troyano , R. Molina Villaverde
{"title":"Protocolo diagnóstico y terapéutico de la sarcopenia en los tumores gastrointestinales","authors":"M. Cruz Gómez ,&nbsp;A. Villalba Yllán ,&nbsp;M.J. Rodríguez Troyano ,&nbsp;R. Molina Villaverde","doi":"10.1016/j.med.2025.01.018","DOIUrl":"10.1016/j.med.2025.01.018","url":null,"abstract":"<div><div>Sarcopenia is an age-related muscle disease characterized by a decrease in skeletal muscle mass, strength, and functionality. The prevalence is very high in patients with gastrointestinal tumors due to the direct involvement of swallowing and digestion. Despite a lack of consensus, it is recommended to screen for nutritional risk at the time the tumor is diagnosed and to develop an individualized treatment plan. The diagnosis of sarcopenia will be made taking into account the low strength and muscle mass according to the criteria proposed by the European Working Group on Sarcopenia in Older People (EWGSOP/EWGSOP2). Early multifactorial treatment based on nutritional and pharmacological therapy together with physical exercise has been shown to decrease the incidence of sarcopenia throughout the course of the disease. Sarcopenia is an independent prognostic factor of tumor disease because it decreases the efficacy of oncological treatments, which increases the rate of tumor recurrence and, in general terms, entails a decrease in survival.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1516-1520"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143322475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paciente varón de 51 años con ictericia indolora, coluria, acolia y prurito de dos semanas de evolución
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.019
J.C. Jiménez Jiménez , M. Herrero Fernández , R. Molina Villaverde
{"title":"Paciente varón de 51 años con ictericia indolora, coluria, acolia y prurito de dos semanas de evolución","authors":"J.C. Jiménez Jiménez ,&nbsp;M. Herrero Fernández ,&nbsp;R. Molina Villaverde","doi":"10.1016/j.med.2025.01.019","DOIUrl":"10.1016/j.med.2025.01.019","url":null,"abstract":"","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1521.e1-1521.e5"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143357297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actualización del cáncer gástrico
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.011
R. Molina Villaverdde , J.I. Busteros , A. Villalba Molina , M. Álvarez-Mon Soto
{"title":"Actualización del cáncer gástrico","authors":"R. Molina Villaverdde ,&nbsp;J.I. Busteros ,&nbsp;A. Villalba Molina ,&nbsp;M. Álvarez-Mon Soto","doi":"10.1016/j.med.2025.01.011","DOIUrl":"10.1016/j.med.2025.01.011","url":null,"abstract":"<div><div>Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor worldwide and is the fourth leading cause of death due to cancer. There are different risk factors that predispose individuals to its onset. Most cases are sporadic, although between 5%–10% of cases have familial aggregation. Histologically, more than 90% are adenocarcinomas. It should be managed through a multidisciplinary approach. In localized and locally advanced stages, a perioperative chemotherapy strategy has been shown to be effective in several randomized studies. In disseminated disease, combinations of chemotherapy with or without immunotherapy are currently used, as well as the combination with trastuzumab in tumors that overexpress HER2 (human epidermal growth factor receptor 2).</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1469-1476"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143357298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actualización del cáncer colorrectal
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.012
B. Martínez-Amores Martínez , A. López Alfonso , M. Durán Poveda , R. Molina Villaverde
{"title":"Actualización del cáncer colorrectal","authors":"B. Martínez-Amores Martínez ,&nbsp;A. López Alfonso ,&nbsp;M. Durán Poveda ,&nbsp;R. Molina Villaverde","doi":"10.1016/j.med.2025.01.012","DOIUrl":"10.1016/j.med.2025.01.012","url":null,"abstract":"<div><div>Colorectal cancer is the most common tumor in Spain and is the second leading cause of death due to cancer after lung cancer. There are well-established risk factors for tumor development, including hereditary syndromes, inflammatory bowel disease, and obesity. The initial clinical symptoms and early detection campaigns make it possible to diagnose this cancer in curable stages in many patients. In localized tumors, surgery is still considered the curative treatment for the disease, although recurrence occurs in a high percentage of patients, which justifies the indication of adjuvant and neoadjuvant therapies. Certain novel strategies, such as intensive follow-up without surgery in localized rectal cancer, have been gaining momentum in recent years, so a change in the future outlook is predicted. In metastatic disease, treatment with chemotherapy, the addition of biologic therapies, immunotherapy in select patients, and salvage surgery achieve long survival times of up to 30–36 months in patients.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1477-1485"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143357299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actualización del cáncer de páncreas
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.013
A. López Alfonso , B. Martínez-Amores , N. Herradón , R. Molina Villaverde
{"title":"Actualización del cáncer de páncreas","authors":"A. López Alfonso ,&nbsp;B. Martínez-Amores ,&nbsp;N. Herradón ,&nbsp;R. Molina Villaverde","doi":"10.1016/j.med.2025.01.013","DOIUrl":"10.1016/j.med.2025.01.013","url":null,"abstract":"<div><div>Exocrine pancreatic cancer is a highly lethal malignant neoplasm. It is the fourth leading cause of death due to cancer in developed countries and, given the gradual increase in incidence, it is expected to become the second leading cause of death due to cancer in the coming years. Surgical resection is the only curative treatment. Since the disease detected in advanced stages in most patients, few will be candidates for a pancreatectomy. Despite this, only 10% of patients will potentially be cured, due to the poor prognosis of this disease and the high proportion of relapses. New treatments have been added in recent years to the small therapeutic arsenal for this disease, which has led to longer survival times. More research is needed to improve this disease's grim prognosis.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1486-1494"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143357301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocolo de prevención y diagnóstico precoz de los tumores digestivos II: cáncer de páncreas y colorrectal
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.01.017
I. Bartolomé Oterino, S. Redondo Evangelista, P. García Centeno, M. Sierra Morales, I. Gala Moreno, A. Santos Rodríguez, N. Hernanz Ruiz
{"title":"Protocolo de prevención y diagnóstico precoz de los tumores digestivos II: cáncer de páncreas y colorrectal","authors":"I. Bartolomé Oterino,&nbsp;S. Redondo Evangelista,&nbsp;P. García Centeno,&nbsp;M. Sierra Morales,&nbsp;I. Gala Moreno,&nbsp;A. Santos Rodríguez,&nbsp;N. Hernanz Ruiz","doi":"10.1016/j.med.2025.01.017","DOIUrl":"10.1016/j.med.2025.01.017","url":null,"abstract":"<div><div>The incidence of pancreatic and colorectal cancers is increasing globally and causes significant morbidity and mortality in our setting. Diagnosis in early stages is one of the most relevant prognostic factors. Early diagnosis is essential in order to improve the prognosis, which is why screening programs have become of particular interest.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 25","pages":"Pages 1511-1515"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143322442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cáncer de próstata
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.02.004
N. González García, N. Fernández-Díaz, P. Freijido-Álvarez, C. Fernández-Reino, M. Giráldez-Martínez, J. Ruíz-Bañobre, L. León-Mateos, U. Anido-Herranz
{"title":"Cáncer de próstata","authors":"N. González García,&nbsp;N. Fernández-Díaz,&nbsp;P. Freijido-Álvarez,&nbsp;C. Fernández-Reino,&nbsp;M. Giráldez-Martínez,&nbsp;J. Ruíz-Bañobre,&nbsp;L. León-Mateos,&nbsp;U. Anido-Herranz","doi":"10.1016/j.med.2025.02.004","DOIUrl":"10.1016/j.med.2025.02.004","url":null,"abstract":"<div><div>Prostate cancer is one of the most common neoplasms in men, with a high incidence worldwide and significant mortality. The disease has a variable course; it usually presents in a fulminant manner, although there are cases of rapidly progressing disease with a very poor prognosis. Most tumors are adenocarcinomas. Its etiology is multifactorial, involving genetic, hormonal, and environmental factors. In 5%-10% of cases, it is associated with germline mutations of genes such as <em>BRCA1, BRCA2,</em> and <em>ATM</em>, and it is described within Lynch syndrome. Prostate cancer staging uses the TNM and Gleason systems to define tumor stage and aggressiveness as well as the best treatment strategy to follow. Treatment ranges from active surveillance in low risk cases, radical treatment with radiotherapy or surgery along with androgen deprivation therapy in localized higher risk stages, the use of hormone therapy for palliative purposes in cases of unresectable recurrence or hormone sensitive metastatic disease, or the use of cytotoxic drugs such as taxane-based chemotherapy in cases of metastatic disease refractory to castration. In some specific cases, treatments such as lutetium, radium, PARP inhibitors, or immunotherapy are considered. Close follow-up is key in order to avoid overdiagnosis and overtreatment.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 26","pages":"Pages 1541-1551"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocolo diagnóstico y terapéutico de la hipercalcemia en el paciente oncológico
Medicine - Programa de Formación Médica Continuada Acreditado Pub Date : 2025-02-01 DOI: 10.1016/j.med.2025.02.006
N. Fernández-Díaz, P. Freijido-Álvarez, P. Pita-López, U. Anido-Herranz, J. Ruíz-Bañobre, L. León-Mateos, R. López-López
{"title":"Protocolo diagnóstico y terapéutico de la hipercalcemia en el paciente oncológico","authors":"N. Fernández-Díaz,&nbsp;P. Freijido-Álvarez,&nbsp;P. Pita-López,&nbsp;U. Anido-Herranz,&nbsp;J. Ruíz-Bañobre,&nbsp;L. León-Mateos,&nbsp;R. López-López","doi":"10.1016/j.med.2025.02.006","DOIUrl":"10.1016/j.med.2025.02.006","url":null,"abstract":"<div><div>Hypercalcemia is a common and serious complication in patients with cancer, especially in cancers with bone metastases. Symptoms range from mild to severe, such as confusion and muscle weakness. The diagnosis is based on the measurement of calcium levels and differentiation from other causes. Treatment includes hydration, bisphosphonates, or denosumab and, in severe cases, hemodialysis. It is essential to treat the underlying malignancy in order to provide long-term control of hypercalcemia and to improve the patient's quality of life.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 26","pages":"Pages 1557-1561"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信