{"title":"Protocolo de indicaciones y profilaxis de la endocarditis infecciosa","authors":"A. González Leal, J.L. Zamorano Gómez","doi":"10.1016/j.med.2025.08.006","DOIUrl":"10.1016/j.med.2025.08.006","url":null,"abstract":"<div><div>Infective endocarditis is a serious disease usually caused by bacteria and, in rare cases, fungi. Proper management involves both preventive measures and specific therapeutic strategies. Infective endocarditis prophylaxis is indicated in patients at high risk, such as those with prosthetic heart valves, a history of previous endocarditis, or high-risk congenital heart disease and is mainly recommended in invasive dental procedures associated with bacteremia. The use of prophylactic antibiotics, such as amoxicillin, is a standard measure in these cases. Treatment of endocarditis is based on prolonged administration of intravenous antibiotics targeting the causative agent identified via blood cultures. In complicated situations, such as heart failure, abscesses, or infection of prosthetic heart valves, surgical management may be necessary. Early detection based on clinical and echocardiographic criteria is essential to improve the prognosis and reduce the serious complications of this disease.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 38","pages":"Pages 2337-2340"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ruiz-Saavedra, F. Luquero-Bachiller, A.J. Herruzo-León, J.A. Serpa-Morán, C. Tejada-González, A. Leandro-Barros, A. García-Lledó
{"title":"Estimación del riesgo cardiovascular: objetivos de control, pruebas de imagen y factores de riesgo emergentes","authors":"A. Ruiz-Saavedra, F. Luquero-Bachiller, A.J. Herruzo-León, J.A. Serpa-Morán, C. Tejada-González, A. Leandro-Barros, A. García-Lledó","doi":"10.1016/j.med.2025.08.012","DOIUrl":"10.1016/j.med.2025.08.012","url":null,"abstract":"<div><div>Assessing cardiovascular risk (CVR) makes it possible to estimate the risk that individuals in a given population have of different cardiovascular events in a given period of time. Performing an assessment requires the identification of risk factors, including age, sex, hypertension, hypercholesterolemia, diabetes, and smoking, in addition to other lifestyle-related risk factors (e.g., sedentary lifestyle), analytical determinations (lipoprotein A, C-reactive protein), or imaging tests (coronary calcium). Using risk assessment tools such as SCORE2, REGICOR, or the Framingham Risk Score, it is possible to obtain a snapshot of the risk of individuals whose risk factors are measured by means of systematic and/or opportunistic screening strategies. The objective of these actions is to help establish measures to prevent atherosclerosis, the basis of most cardiovascular diseases. A healthy lifestyle should be promoted in all individuals (Mediterranean diet, exercise, smoking cessation) and, depending on the estimated risk, personalized drug treatments. Factors such as frailty, family history, and socioeconomic status complement the assessment and help personalize risk management. Effective doctor-patient communication and treatment adherence are key to ensuring successful prevention and management of CVR.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 39","pages":"Pages 2372-2384"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protocolo terapéutico de la endocarditis infecciosa","authors":"A. González Leal, J.L. Zamorano Gómez","doi":"10.1016/j.med.2025.08.007","DOIUrl":"10.1016/j.med.2025.08.007","url":null,"abstract":"<div><div>Infective endocarditis is a serious disease. Its treatment is based on a multidisciplinary approach that combines targeted antimicrobial therapy and, in some cases, surgery. Early diagnosis, based on the Duke criteria and studies such as blood cultures and echocardiography, is essential to guide management. Antimicrobial therapy is chosen according to the causative microorganism. Bactericidal antibiotics, which are essential, are administered intravenously for a prolonged period, usually four to six weeks. In cases of infection by <em>Staphylococcus aureus</em>, enterococci, or resistant microorganisms, specific combinations of antibiotics are used. Cardiac surgery is indicated in patients with heart failure, uncontrolled infections, or presence of large vegetations with risk of embolization. This comprehensive approach improves survival and reduces complications such as septic embolism and heart valve dysfunction.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 38","pages":"Pages 2341-2346"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Varón de 81 años con EPOC e hipertensión arterial con soplo cardíaco aórtico y disnea","authors":"A. González Leal, J.L. Zamorano Gómez","doi":"10.1016/j.med.2025.08.008","DOIUrl":"10.1016/j.med.2025.08.008","url":null,"abstract":"","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 38","pages":"Pages 2347.e1-2347.e3"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ruiz-Saavedra, J. García-Pérez-Velasco, J.A. Serpa-Morán, C. Tejada-González, A. Leandro-Barros
{"title":"Protocolo terapéutico de la hipertensión arterial: población general y poblaciones especiales","authors":"A. Ruiz-Saavedra, J. García-Pérez-Velasco, J.A. Serpa-Morán, C. Tejada-González, A. Leandro-Barros","doi":"10.1016/j.med.2025.08.017","DOIUrl":"10.1016/j.med.2025.08.017","url":null,"abstract":"<div><div>Current recommendations for the management of hypertension (HT) include lifestyle changes such as following the Mediterranean diet, regular exercise, and restricting salt intake. When necessary, it is recommended to initiate pharmacological treatment with two antihypertensive drugs at low doses, preferably combined as a polypill. In resistant HT, options include spironolactone, renal denervation, and individualized treatments for special subgroups.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 39","pages":"Pages 2411-2416"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Tejada-González, A.J. Herruzo-León, F. Luquero-Bachiller, J. Serpa-Morán, A. Leandro-Barros, A. Ruiz-Saavedra, C. Torán-Martínez, A. García-Lledó
{"title":"Ateroesclerosis. Etiopatogenia. Placa estable y placa vulnerable. Rotura de placa. Resumen de las manifestaciones clínicas a nivel sistémico","authors":"C. Tejada-González, A.J. Herruzo-León, F. Luquero-Bachiller, J. Serpa-Morán, A. Leandro-Barros, A. Ruiz-Saavedra, C. Torán-Martínez, A. García-Lledó","doi":"10.1016/j.med.2025.08.009","DOIUrl":"10.1016/j.med.2025.08.009","url":null,"abstract":"<div><div>Atherosclerosis is a chronic disease characterized by the deposition of lipids in the intima layer of medium- and large-caliber arteries that causes the formation of atheromatous plaques. It is one of the main causes of morbidity and mortality worldwide. Risk factors include hypercholesterolemia, diabetes, hypertension, and unhealthy habits. The development of plaques, which is closely linked to risk factors, begins with endothelial dysfunction and the accumulation of oxidized LDL cholesterol followed by inflammation and cell migration. This generates a vicious cycle that increases the risk of cardiovascular events such as heart attacks and strokes. It is a phenomenon of lipid infiltration, inflammation, and repair whose balance depends on the stability of the plaques, which can be stable or vulnerable. Inflammation plays a central role in disease progression. It is mediated by macrophages and foam cells that secrete proinflammatory cytokines. Other mechanisms, such as hypoxia and reverse cholesterol transport, influence plaque stability. Clinical manifestations include ischemic heart disease, cerebrovascular disease, peripheral arterial disease, and renal and oncologic complications. The therapeutic approach includes primary and secondary prevention by controlling risk factors and specific therapies to stabilize plaques and reduce acute events.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 39","pages":"Pages 2349-2356"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Tejada-González, V. Bonilla-Jiménez, A. Leandro-Barros, J. Serpa-Morán, C. Tejada-González, A. Ruiz-Saavedra
{"title":"Factores de riesgo mal controlados, nuevo infarto asegurado","authors":"C. Tejada-González, V. Bonilla-Jiménez, A. Leandro-Barros, J. Serpa-Morán, C. Tejada-González, A. Ruiz-Saavedra","doi":"10.1016/j.med.2025.08.018","DOIUrl":"10.1016/j.med.2025.08.018","url":null,"abstract":"","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 39","pages":"Pages 2417.e1-2417.e3"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ruiz-Saavedra , J. García-Pérez-Velasco , J.A. Serpa-Morán , C. Tejada-González , A. Leandro-Barros , A. García-Lledó
{"title":"Hipertensión arterial: etiopatogenia, clínica, historia natural, complicaciones y tratamiento. Hipertensión arterial en el anciano y en el embarazo","authors":"A. Ruiz-Saavedra , J. García-Pérez-Velasco , J.A. Serpa-Morán , C. Tejada-González , A. Leandro-Barros , A. García-Lledó","doi":"10.1016/j.med.2025.08.013","DOIUrl":"10.1016/j.med.2025.08.013","url":null,"abstract":"<div><div>Hypertension (HT) is a complex disease characterized by a persistent increase in blood pressure associated with an increased risk of certain complications and premature death. This update provides an analysis of the fundamental concepts related to HT, including its etiology, etiopathogenic mechanisms, clinical manifestations, natural history of the disease, associated complications, and treatment strategies, with a particular focus on vulnerable groups such as older adults and pregnant people. In addition, risk factors and cardiovascular risk modifiers are studied. The importance of detecting resistant and secondary hypertension is emphasized as well as the effect of lifestyle habits and comorbidities on disease progression. Treatment includes, among other measures, lifestyle modifications, following a Mediterranean diet, reducing sodium intake, weight control, regular exercise, and a personalized pharmacological approach that combines angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers (ARBs), calcium channel blockers, and diuretics. New strategies such as renal denervation and the use of innovative agents such as GLP-1 receptor agonists and aldosterone synthase inhibitors are discussed.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 39","pages":"Pages 2385-2399"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protocolo diagnóstico y terapéutico de la valvulopatía aórtica en el anciano","authors":"A. González Leal, J.L. Zamorano Gómez","doi":"10.1016/j.med.2025.08.004","DOIUrl":"10.1016/j.med.2025.08.004","url":null,"abstract":"<div><div>Aortic valve disease, predominantly aortic stenosis, is a common condition in older adults due to aging and progressive calcification of the aortic valve. In this population, symptoms such as dyspnea, angina, and syncope are frequent and associated with a worse prognosis if not treated promptly. Diagnosis includes a detailed clinical evaluation together with echocardiographic studies, which are essential in order to determine the severity and hemodynamic repercussion of the disease. Other tools such as computed tomography may be useful to assess valve calcification. The treatment of older adults requires an individualized approach that considers frailty and comorbidities. Valve replacement, either by conventional surgery or transcatheter aortic valve implantation (TAVI), is the mainstay of treatment in patients with severe symptomatic stenosis. TAVI has emerged as a less invasive option and is currently the preferred choice in older adults at high surgical risk.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 38","pages":"Pages 2324-2330"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Valvulopatía mitral","authors":"A. González Leal, J.L. Zamorano Gómez","doi":"10.1016/j.med.2025.08.002","DOIUrl":"10.1016/j.med.2025.08.002","url":null,"abstract":"<div><div>The mitral valve is a complex structure responsible for directing flow from the left atrium to the left ventricle. Mitral valve disease can manifest mainly as mitral stenosis, mitral insufficiency, or a combination of both. Mitral stenosis, often associated with rheumatic fever, causes narrowing of the valve, making it difficult for blood to flow to the ventricle. On the other hand, mitral insufficiency is characterized by incomplete closure of the mitral valve, allowing blood to leak backward into the left atrium during ventricular systole. Both conditions generate hemodynamic overload; cardiac remodeling; and symptoms such as dyspnea, fatigue, and arrhythmias. Atrial fibrillation is also a common complication. Diagnosis is based on a clinical assessment and echocardiographic studies. In some cases, more advanced tests, such as cardiac magnetic resonance imaging or computed tomography, or invasive tests, such as cardiac catheterization, are required. Treatment ranges from medical management to relieve symptoms to surgical or percutaneous interventions such as valve replacement or repair. A comprehensive understanding of mitral valve disease is key to an effective approach and improving these patients’ quality of life.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 38","pages":"Pages 2304-2316"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}