{"title":"Protocolo terapéutico de la insuficiencia respiratoria aguda","authors":"M. Longás, D. Romero, B. Sánchez, D. Laorden","doi":"10.1016/j.med.2026.10.005","DOIUrl":"10.1016/j.med.2026.10.005","url":null,"abstract":"<div><div>Acute respiratory failure (ARF) requires an early intervention aimed at ensuring adequate gas exchange and reducing the work ofbreathing. This protocol proposes a stepwise management approach in the hospital setting based on rapid identification of the phenotype (hypoxemic, hypercapnic, or mixed), setting oxygenation targets (SpO<sub>2</sub> 92%-96% in patients without a risk of hypercapnia and 88%-92% in patients at risk), and close reassessment. The choice of initial support is tailored to the phenotype and severity: conventional oxygen therapy is used for mild-to-moderate hypoxemic ARF while high-flow oxygen therapy is recommended for moderate-to-severe hypoxemic ARF. In hypercapnic ARF with acidosis (as well as in acute cardiogenic pulmonary edema or hypoventilation due to neuromuscular/chest wall disease), noninvasive mechanical ventilation is the first-line treatment. Emphasis is placed on early detection of failure of noninvasive support, simultaneous etiological treatment, and general supportive care.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3916-3920"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Arteaga, E. De Dios, C. Carpio, M. Hidalgo, R. Álvarez-Sala
{"title":"Fisiopatología de la ventilación y del intercambio gaseoso","authors":"M. Arteaga, E. De Dios, C. Carpio, M. Hidalgo, R. Álvarez-Sala","doi":"10.1016/j.med.2026.10.001","DOIUrl":"10.1016/j.med.2026.10.001","url":null,"abstract":"<div><div>Pathophysiology of ventilation and gas exchange Respiratory physiology integrates ventilatory mechanics, gas exchange, and neural control of breathing to ensure adequate tissue oxygenation and carbon dioxide elimination. Pulmonary mechanics depend on the elastic properties of the lungs and the thoracic cage as well as airway resistance, which determine respiratory effort and ventilatory efficiency. Lung volumes and capacities allow for identifying obstructive and restrictive patterns with important diagnostic and prognostic implications.</div><div>Gas exchange is primarily determined by the ventilation-perfusion ratio. An imbalance in this ratio is the most common mechanism of hypoxemia in most respiratory diseases. Alveolar-capillary diffusion has a large functional reserve under normal conditions, but can be impaired in the presence of interstitial diseases, emphysema, intense exercise, or exposure to high altitudes. Respiratory control integrates chemical and mechanical signals that modulate ventilation in chronic obstructive pulmonary disease and obstructive sleep apnea.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3881-3888"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Navarro, C. García-Quero, M.A. Gómez-Mendieta, E. Zamarrón
{"title":"Protocolo de monitorización y seguimiento ambulatorio del paciente con insuficiencia respiratoria crónica. Criterios de alarma","authors":"S. Navarro, C. García-Quero, M.A. Gómez-Mendieta, E. Zamarrón","doi":"10.1016/j.med.2026.10.008","DOIUrl":"10.1016/j.med.2026.10.008","url":null,"abstract":"<div><div>Chronic respiratory failure (CRF) is a highly complex disease that requires structured outpatient follow-up to improve quality of life and enable early detection of exacerbations. This protocol defines the management of patients receiving home long-term oxygen therapy (LTOT) and home mechanical ventilation (HMV), including prescribing criteria, periodic follow-up, adherence, and discontinuation of treatment. HMV monitoring is tailored to the degree of ventilatory dependence and prioritizes the safety and education of patients and caregivers. Telemedicine is proposed as a complementary tool to improve accessibility and early detection of clinical deterioration, along with clear alarm criteria to prevent hospital readmissions.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3931-3934"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Romero, D. Corchado, D. Velasco, C. Prados, A. Pérez-Figuera
{"title":"Insuficiencia respiratoria: concepto, etiopatogenia, clasificación y diagnóstico","authors":"B. Romero, D. Corchado, D. Velasco, C. Prados, A. Pérez-Figuera","doi":"10.1016/j.med.2026.10.003","DOIUrl":"10.1016/j.med.2026.10.003","url":null,"abstract":"<div><div>Respiratory failure is a clinical pathophysiological syndrome characterized by impaired gas exchange that leads to hypoxemia, hypercapnia, or both. It is defined by an arterial oxygen pressure (PaO<sub>2</sub>) below 60<!--> <!-->mm Hg and/or an arterial carbon dioxide pressure (PaCO<sub>2</sub>) above 45<!--> <!-->mm Hg under baseline conditions at sea level. Its origin is related to abnormalities in the main mechanisms of respiratory physiology, including ventilation/perfusion imbalance, intrapulmonary shunting, alveolar hypoventilation, diffusion limitation, and decreased fraction of inspired oxygen pressure. From a pathophysiological perspective, it is classified into hypoxemic and hypercapnic forms with acute, chronic, and acute-on-chronic presentations, each with specific prognostic and therapeutic implications. Arterial blood gas analysis is the gold standard for diagnosis, severity stratification, and assessment of acid-base balance. An integrated approach based on a clinical and physiological evaluation is essential for early recognition, individualized decision making regarding treatment, and optimization of clinical outcomes.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3900-3907"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Aponte, A. Iglesias, S. Alcolea, Y. Martínez-Abad, L. Esteban
{"title":"Protocolo de tratamiento de la insuficiencia respiratoria en urgencias","authors":"C. Aponte, A. Iglesias, S. Alcolea, Y. Martínez-Abad, L. Esteban","doi":"10.1016/j.med.2026.10.007","DOIUrl":"10.1016/j.med.2026.10.007","url":null,"abstract":"<div><div>Acute respiratory failure is a common cause for presenting to the emergency department and is associated with high morbidity and mortality. Its management requires early assessment and a structured approach to identify the severity, pathophysiological mechanism, and underlying etiology. With the aim of improving clinical decision-making, this protocol reviews the diagnostic approach and main strategies for respiratory support—ranging from conventional oxygen therapy to noninvasive ventilation—as well as etiological treatment.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3926-3930"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Martínez-Redondo, A. Pérez Figuera, D. Romera, A. Mangas
{"title":"Síndrome de platipnea-ortodeoxia como causa infrecuente de insuficiencia respiratoria grave en el adulto mayor, a propósito de un caso","authors":"M. Martínez-Redondo, A. Pérez Figuera, D. Romera, A. Mangas","doi":"10.1016/j.med.2026.10.009","DOIUrl":"10.1016/j.med.2026.10.009","url":null,"abstract":"","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3935.e1-3935.e3"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Galera, R. Casitas, F. García Río, C. Crespo, M. Bonet
{"title":"Pruebas de función respiratoria","authors":"R. Galera, R. Casitas, F. García Río, C. Crespo, M. Bonet","doi":"10.1016/j.med.2026.10.002","DOIUrl":"10.1016/j.med.2026.10.002","url":null,"abstract":"<div><div>This update provides a simple, educational overview of the main respiratory function tests used in clinical practice: spirometry, the utility of the bronchodilator test, measurement of respiratory volumes, diffusing capacity of the lungs for carbon monoxide (DLCO), cardiopulmonary exercise test, and arterial blood gas analysis, focusing on their physiological basis, techniques for performing them, indications, and clinical interpretation.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3889-3899"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Selles, B. Sanz-Sanjosé, V. Arnalich, J. Fernández-Lahera, A. Santiago
{"title":"Oxigenoterapia y ventilación mecánica","authors":"J. Selles, B. Sanz-Sanjosé, V. Arnalich, J. Fernández-Lahera, A. Santiago","doi":"10.1016/j.med.2026.10.004","DOIUrl":"10.1016/j.med.2026.10.004","url":null,"abstract":"<div><div>This document reviews the essential principles of oxygen therapy and ventilatory support. Oxygen therapy is indicated to correct hypoxemia and can be administered via low- or high-flow systems, among which high-flow nasal cannula (HFNC) stands out for its ability to generate positive end-expiratory pressure (PEEP), improve CO<sub>2</sub> clearance, humidify the air, and reduce respiratory effort. It describes adjustments based on the underlying condition and highlights the importance of cannula design.</div><div>Noninvasive ventilation (NIV) includes continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP), and advanced modes such as average volume-assured pressure support (AVAPS). It is particularly useful in acute exacerbations of chronic obstructive pulmonary disease (COPD) and in acute pulmonary edema. Criteria for success and failure as well as risks such as patient-self-inflicted lung injury (P-SILI) are detailed. Invasive mechanical ventilation (IMV) is reserved for severe respiratory failure. Lung-protective ventilation is emphasized and common complications such as ventilator-associated pneumonia (VAP), barotrauma, and delirium are listed.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3908-3915"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protocolo terapéutico de la insuficiencia respiratoria crónica","authors":"M. Aguilar, P. Mariscal, L. Gómez, I. Fernández","doi":"10.1016/j.med.2026.10.006","DOIUrl":"10.1016/j.med.2026.10.006","url":null,"abstract":"<div><div>Respiratory failure (RF) is a clinical syndrome characterized by the respiratory system's inability to perform its functions: oxygenating the blood and eliminating carbon dioxide. Chronic respiratory failure (CRF) is defined by the development of adaptive mechanisms. Its management includes general measures focused on smoking cessation, vaccination, nutritional supplementation, disease control, and respiratory rehabilitation. Home long-term oxygen therapy (LTOT) has been shown to increase survival in patients with CRF secondary to chronic obstructive pulmonary disease (COPD). Home mechanical ventilation (HMV) also increases long-term survival. However, pharmacological treatment with acetazolamide remains controversial.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 63","pages":"Pages 3921-3925"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D.F. Febres Panez, J.J. Arechederra Calderón, N. Bassy Iza, V.E. Landaeta Ribera, H.D. Villa Alvarado, P.M. Duluc Escobar
{"title":"Malnutrición, disfagia, anorexia, sarcopenia y obesidad sarcopénica","authors":"D.F. Febres Panez, J.J. Arechederra Calderón, N. Bassy Iza, V.E. Landaeta Ribera, H.D. Villa Alvarado, P.M. Duluc Escobar","doi":"10.1016/j.med.2026.09.003","DOIUrl":"10.1016/j.med.2026.09.003","url":null,"abstract":"<div><div>Malnutrition and its determinants (anorexia of aging, dysphagia, and sarcopenia, including sarcopenic obesity) are highly prevalent geriatric syndromes with significant clinical, functional, and prognostic implications for older adults. This update reviews the current evidence on the screening, diagnosis, and comprehensive management of malnutrition in older adults from a clinical and functional perspective. It also reviews the main nutritional screening tools in geriatrics and their integration with the GLIM diagnostic criteria. It analyzes anorexia of aging and dysphagia as key nutritional risk factors as well as sarcopenia and sarcopenic obesity, including their assessment using body composition techniques and their relationship to functional decline, dependency, and mortality. Finally, it summarizes the principles of management, which are based on multimodal interventions focused on personalized nutrition, multicomponent exercise, and a selective use of emerging pharmacological therapies. Systematic nutritional assessment, integrated into comprehensive geriatric assessment, is essential for the early identification and treatment of malnutrition and its determinants. A multidimensional and individualized approach improves functional status and reduces dependence and mortality in older adults.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 62","pages":"Pages 3835-3845"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}