{"title":"Enhancing the flexibility and thermal properties of polylactic acid/thermoplastic starch blends through selective plasticization","authors":"Maedeh Zamani , Mohammad Fasihi , Sajad Rasouli","doi":"10.1016/j.carpta.2025.100780","DOIUrl":"10.1016/j.carpta.2025.100780","url":null,"abstract":"<div><div>This study investigates the impact of polyethylene glycol (PEG) and dioctyl terephthalate (DOTP) as plasticizers on the mechanical, microstructural, thermal, and crystalline properties of polylactic acid/thermoplastic starch (PLA/TPS) blends. While plasticization reduced tensile and Izod impact strengths by 60 %, it significantly improved ductility and impact strength by 268 % when using DOTP and lower molecular weight PEG (LWPEG), due to their lubrication capabilities and decreased frictional forces between polymer chains. This facilitated easier disentanglement before the chains ruptured under the load. Morphological analysis revealed a well-dispersed droplet-matrix structure with smaller droplet sizes (22.41 ± 4.9 μm for DOTP and 20.98 ± 4.7 μm for LWPEG) compared to pure PLA/TPS (49.97 ± 14.3 μm). Differential scanning calorimetry (DSC) showed reduced glass transition, crystalline, and melting temperatures, with plasticizers migrating to the TPS phase, enhancing crystallinity. DOTP, in particular, promoted β-type crystal formation, improving Young's modulus, ductility, and impact strength. Overall, DOTP demonstrated superior plasticization effects, yielding the best droplet-matrix morphology and highest crystallinity, making it the most effective plasticizer for enhancing PLA/TPS properties.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100780"},"PeriodicalIF":6.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.C. García-Laynez , M. Herrera , S.I. Molina , A. Sanz de León
{"title":"Chitin nanocrystals as bio-based adhesives for the development of sustainable cork composites","authors":"M.C. García-Laynez , M. Herrera , S.I. Molina , A. Sanz de León","doi":"10.1016/j.carpta.2025.100783","DOIUrl":"10.1016/j.carpta.2025.100783","url":null,"abstract":"<div><div>In this work, we demonstrate the potential of chitin nanocrystals (ChNCs), a sustainable and biobased nanomaterial, as an adhesive for valorizing cork waste and fabricating fully biobased composites through compression molding. SEM and XCT analyses confirmed that, when used at concentrations below 30 wt.%, ChNCs integrate homogeneously with cork by adhering uniformly to the cork cell walls, preserving its low density and inherent flexibility. Notably, composites containing 20 wt.% of ChNCs achieved superior mechanical properties (i.e. flexibility, strength and toughness) compared to composites with paraffin over a broad concentration range (5–70 wt.%). Unlike paraffin, which increases density by filling the cork cells, ChNCs maintain the porous structure while significantly enhancing compressive performance. These findings highlight the exceptional adhesive and reinforcing capabilities of ChNCs, paving the way for their use as a natural binder in developing sustainable cork composites and extending this approach to other agrowaste materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100783"},"PeriodicalIF":6.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Facile in situ synthesis of ZnO-infused caseinate/carboxymethyl cellulose films with antibacterial properties for cheddar cheese packaging","authors":"Bai Qu, Zhenlei Xiao, Yangchao Luo","doi":"10.1016/j.carpta.2025.100779","DOIUrl":"10.1016/j.carpta.2025.100779","url":null,"abstract":"<div><div>This study presents a green, one-step approach for the in situ synthesis of zinc oxide (ZnO) particles within a sodium caseinate (NaCas) and carboxymethyl cellulose (CMC) matrix, with functionality enhanced by thymol essential oil. Acting as a natural reducing agent, thymol facilitated ZnO synthesis within the NaCas-CMC matrix. The film prepared with 300 mg zinc nitrate and 100 mg thymol essential oil had a low swelling rate due to in situ ZnO formation, which regulated the microstructure and enhanced hydrophobicity. The ZnO-infused NaCas-CMC biocomposite films exhibited enhanced UV shielding and water resistance, attributed to the uniform dispersion of ZnO particles and their synergistic interaction with thymol. Antibacterial assays demonstrated strong inhibitory effects against key foodborne pathogens, including<em>Listeria monocytogenes</em> (<em>L. monocytogenes</em>) and <em>Escherichia coli</em> K-12 (<em>E. coli</em> K-12). When applied to cheddar cheese, the films significantly suppressed microbial growth and effectively prevented external contamination, maintaining product safety over 20 days of refrigerated storage. Overall, this research highlights the potential of a green synthesis approach to develop multifunctional packaging films that enhance food safety while supporting sustainable practices, offering a promising alternative to conventional food packaging materials. Notably, this is the first report to describe the in situ synthesis of ZnO within a self-assembled caseinate film containing thymol essential oil, employing a surfactant-free and environmentally friendly processing method.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100779"},"PeriodicalIF":6.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Profile and content of fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) compounds in wheat and rye wholegrain foods","authors":"Aleksandra M. Torbica , Uroš Miljić , Olja Todorić , Miona Belović , Tamara Erceg , Milorad Miljić , Miloš Radosavljević","doi":"10.1016/j.carpta.2025.100772","DOIUrl":"10.1016/j.carpta.2025.100772","url":null,"abstract":"<div><div>This study aimed to provide insight into the content and profile of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) found in various types of wheat and rye wholegrain products available on the market. As dietary fiber is recommended to be consumed at a minimum of 25 g per day for its beneficial health effects, wholegrain products are an important and affordable source of this staple nutrient. However, FODMAPs can have contrasting effects on the metabolism of healthy individuals and those suffering from gastrointestinal disorders, particularly irritable bowel syndrome. This has increased the multidisciplinary research into FODMAPs over the last two decades.</div><div>In 92 samples of cereal-based foods, the total fructan content was measured using a commercially enzymatic kit. The exsess of fructose, melibiose, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and sugar polyols were determined using HPAEC-PAD method.All the analyzed pasta samples, and 88.24 % of the bread samples can be characterized as high-FODMAP products, while cookies (26.67 %) and crackers (0.00 %) were predominantly low-FODMAP products. Observing the results of all analyzed samples it can be concluded that the variations of FODMAPs content could be due to grain type, variety, climate conditions, agricultural measures, grain processing techniques (mostly milling), and type of obtained flour, as well as type of fermentation and thermal processing in the food production (shaped by the dietary habits of different cultures and regions). It was also concluded that the content of total fructo-oligosaccharides instead of total fructans should be used for the definition of the FOS content. Furthermore, the GOS content was shown to contribute significantly to the total FODMAP content.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100772"},"PeriodicalIF":6.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellulose-based interdigitated electrodes for rivaroxaban apta-sensing in blood plasma","authors":"Rokhsareh Ebrahimi , Mohammad Hasanzadeh , Azadeh Nilghaz , Nasrin Shadjou","doi":"10.1016/j.carpta.2025.100778","DOIUrl":"10.1016/j.carpta.2025.100778","url":null,"abstract":"<div><div>Monitoring of Rivaroxaban (RIV) at trace levels in patients at risk of atrial fibrillation disorders (AFD) is of great importance. In this study, for the first time, a miniaturized interdigitated electrode (mIDE) biosensor was fabricated using superconducting silver nano ink for the detection of RIV in human plasma. The biosensor exhibited a linear detection range of 10–1000 nM with a lower limit of quantification of 10 nM. The specificity of the biosensor was also validated through square wave voltammetry in the presence of potential interfering compounds, confirming its selectivity and reliability. Based on obtained results, integration of biosensor technology and flexible electronics enhance the mIDE performance, making it a promising tool for real-time monitoring of RIV levels in clinical settings, especially for atrial fibrillation. This low-cost device shows great potential for the pharmaceutical analysis.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100778"},"PeriodicalIF":6.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Separation and characterization of high- and low-molecular-weight polysaccharides from Caulerpa lentillifera","authors":"Ratana Chaiklahan, Channarong Suaisom, Nattayaporn Chirasuwan, Thanyalak Srinorasing","doi":"10.1016/j.carpta.2025.100776","DOIUrl":"10.1016/j.carpta.2025.100776","url":null,"abstract":"<div><div><em>Caulerpa lentillifera</em> is a rich source of sulfated polysaccharides with potential applications in nutraceuticals, pharmaceuticals, and cosmeceuticals. However, limited information is available on low-molecular-weight polysaccharides (LMWPs) and the secondary metabolites bound to or associated with polysaccharides. This study aimed to separate high-molecular-weight polysaccharides (HMWPs) and LMWPs using 0.2 µm and 10 kDa membranes to yield retentate (R0.2) and R10 extracts, respectively. Furthermore, secondary metabolites in the R10 extract were analyzed using liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS/MS). The R0.2 extract (HMWP) contained high levels of total sugars (69.28 % of extract weight) and sulfates (13.49 %) as the major functional groups, whereas the R10 extract (LMWP) contained high levels of uronic acid (6.04 %) and phenolic compounds (11.52 mg gallic acid equivalent (GAE)/g extract). Fractionation using diethylaminoethyl (DEAE)-Sepharose fast flow and Sepharose 6B gel filtration columns revealed six HMWP fractions in the R0.2 extract, with molecular weights (MWs) of 1770, 2421, 1657, 1293, 1180, and 1187 kDa. In contrast, the five LMWP fractions in the R10 extract exhibited MWs of 8.6, 15.7, 37.9, 44.3, and 16.9 kDa. LC-ESI-QTOF-MS/MS analysis of the R10 extract identified several antioxidant compounds, including quercetagetin (<em>m/z</em> 319.2872 [M+H]<sup>+</sup>) and quercetin (<em>m/z</em> 301.0362 [M–H]<sup>–</sup>), which contributed to its potent antioxidant activity. These findings highlight the potential of the R10 extract for health promotion and disease prevention.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100776"},"PeriodicalIF":6.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proteomic analysis reveals a potential anticancer mechanism for a novel effervescent curcumin-ascorbic acid-polysaccharide-β-cyclodextrin inclusion complex towards colorectal cancer cells through modulation of ribosome biogenesis","authors":"Atthapan Morchang , Keerakarn Somsuan , Artitaya Rongjumnong , Churat Weeraphan , Sasivimon Pramual , Theetat Ruangjaroon , Daranee Chokchaichamnankit , Wuttichai Jaidee , Phateep Hankittichai , Chanatip Pramvichai , Rawiwan Charoensup , Arunothai Wanta , Chantragan Srisomsap , Jisnuson Svasti , Siripat Aluksanasuwan","doi":"10.1016/j.carpta.2025.100775","DOIUrl":"10.1016/j.carpta.2025.100775","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is a major global health issue due to its aggressiveness and high mortality rates. While curcumin, the bioactive compound from turmeric (<em>Curcuma longa</em> L.), exhibits anticancer properties, its low water solubility limits therapeutic potential. The present study developed a novel effervescent curcumin-ascorbic acid-polysaccharide-β-cyclodextrin (CUR-A-Poly-β-CD) inclusion complex to enhance solubility and evaluated its anticancer potential in CRC cell lines. The complex exhibited a zeta potential of -22.9 ± 1.1 mV, a particle size of 496.8 ± 1.9 nm, a solubility of 13.6 mg/L, and a pH of 4.5. CUR-A-Poly-β-CD was non-toxic to normal colon cells (CCD-841 CoN) but significantly reduced the viability of CRC cell lines HT-29, SW-48, and SW-480, with SW-480 cells being the most responsive. CUR-A-Poly-β-CD induced apoptosis and inhibited proliferation, clonogenicity, and migration of SW-480 cells. Proteomic analysis identified 105 altered proteins in SW-480 cells treated with CUR-A-Poly-β-CD, primarily involved in cell growth and ribosome biogenesis pathways. Western blot analysis confirmed increased levels of ribosomal proteins RPL13a and RPS3. In conclusion, the CUR-A-Poly-β-CD inclusion complex demonstrates anticancer effects against CRC by modulating ribosome biogenesis. These findings suggest its potential as a therapeutic approach to improve the effectiveness of CRC treatments.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100775"},"PeriodicalIF":6.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Horse chestnut starch: Structure, properties, modification and its applications-A review","authors":"Farhana Mehraj Allai , Jasia Nissar , Asima Shafi , Mehvish Bashir , Mehreen , Insha Zahoor , Tariq Ahmad Ganaie , Khalid Gul , Tehmeena Ahad","doi":"10.1016/j.carpta.2025.100755","DOIUrl":"10.1016/j.carpta.2025.100755","url":null,"abstract":"<div><div>Horse chestnut (<em>Aesculus indica</em>) is an underutilized nut, accounting for approximately 60 % of the total starch present in its seed. Horse chestnut has potentials as a source of commercially available starches since it is widely distributed in Asia, Japan, Europe, America and China with minimal input costs. As the major component of horse chestnut seeds, starch is considered as a cheap and sustainable carbohydrate source in comparison to other conventional sources. Herein, this review aims to highlight the composition, isolation methods, structural characteristics, functional properties and modifications as well as potential applications of horse chestnut starch. Horse chestnut starch has high amylose content (33.1 %) renders it a promising source of resistant and low digestible starch. The structural characteristics of horse chestnut starch differs from other common starches, influencing its swelling power, solubility, transparency, freeze-thaw stability, pasting, gelatinization and retrogradation. However, Horse chestnut starch exhibits distinctive structural profile with high short chains, which correlates with its pasting viscosity. To increase its versatility and applicability, horse chestnut starch has been modified by physical, chemical and enzymatic treatments. This review also provides a basis for utilizing horse chestnut starch in food and non-food fields. To expand its potential utilization, future research demands on horse chestnut starch are also discussed.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100755"},"PeriodicalIF":6.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huanyan Wang , Meihui Qin , Xianghui Wei , Bi Lv , Emily Sze Wan Wong , Jianwei Zhai , Keng Po Lai , Rong Li
{"title":"Fucoidan for potentially treating amblyopia: Autophagy-associated targets and therapeutic mechanisms","authors":"Huanyan Wang , Meihui Qin , Xianghui Wei , Bi Lv , Emily Sze Wan Wong , Jianwei Zhai , Keng Po Lai , Rong Li","doi":"10.1016/j.carpta.2025.100770","DOIUrl":"10.1016/j.carpta.2025.100770","url":null,"abstract":"<div><div>Amblyopia is a pediatric disorder characterized by reduced visual acuity and remains a major pediatric health challenge. Currently, effective drug therapies for amblyopia are limited. Therefore, screening and exploring potential bioactive compounds are promising strategies for treating amblyopia. Fucoidan, extracted from marine rockweed, exhibits significant pharmacological properties via the regulation of autophagy, including neuroprotective benefits. Therefore, the present study aims to identify the neuroprotective targets and pharmacological mechanisms of fucoidan against amblyopia via autophagy. Using a network pharmacology approach, 8 core target genes were identified, including MTOR, PIK3CA, PTPN11, PIK3CB, PIK3CG, TLR4, PDGFRA, and FLT3. GO and KEGG pathway analyses highlighted the role of these targets in association with brain and neuronal axon development, by targeting the ephrin receptor and brain-derived neurotrophic factor-receptor signaling pathways. Furthermore, spatial docking simulations revealed that fucoidan exhibits effective docking affinity for PIK3CA, PTPN11, and PDGFRA. Collectively, these preclinical findings provide key evidence for the neuroprotective targets and pharmacological mechanisms of fucoidan against amblyopia by regulating autophagy, thus concluding that fucoidan may be a potential therapeutic agent for managing amblyopia. The findings of the current study were derived from a systematic bioinformatics analysis; however, additional experimental and pre-clinical studies are necessary to confirm these results.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100770"},"PeriodicalIF":6.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahmoud Kamal , Lin Zhu , Mohamed E. Abd El-Hack , Muhammad Arif , Fengming Li , Yanfen Cheng
{"title":"Functional roles of mannan and chitosan oligosaccharides on animal health and nutrition: A review","authors":"Mahmoud Kamal , Lin Zhu , Mohamed E. Abd El-Hack , Muhammad Arif , Fengming Li , Yanfen Cheng","doi":"10.1016/j.carpta.2025.100764","DOIUrl":"10.1016/j.carpta.2025.100764","url":null,"abstract":"<div><div>Mannan-oligosaccharides (MOS) and chitosan-oligosaccharides (COS) are low-molecular-weight carbohydrates with 2 to 20 monosaccharides associated with glycosidic bonds positioned among monosaccharides and polysaccharides. They promote growth, regulate immunity, enhance gut microbiota structure, and exhibit anti-inflammatory and antioxidant properties. Due to the worldwide enforcement of antibiotic restriction policies, oligosaccharides (Olig) have garnered increased attention as novel green feed supplements. Based on how they digest, they can be put into two groups: functional COS and MOS, which are not easily absorbed and have specific physiological roles, and widespread Olig, like sucrose and maltose, which are easily absorbed by the intestine. The prevalent functional Olig comprise COS, MOS, fructo-oligosaccharides (FOS), and xylo-oligosaccharides (XOS), among others. Functional MOS and COS serve as a superior functional feed base, acting as nutritional fiber and prebiotics to enhance the diet, optimize gut microecology, and provide anticancer, antioxidant, anti-inflammatory, and lipid-lowering effects. This review examines the varieties of functional MOS and COS, their utilization in animal and poultry feeding, and the variables that have constrained their effectiveness in this century. This review establishes the theoretical foundation for upcoming studies on multifunctional MOS and COS and the prospective use of substitute antibiotics in the livestock and poultry sectors.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100764"},"PeriodicalIF":6.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}