Carbohydrate Polymer Technologies and Applications最新文献

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Blue-fluorescent cellulose nanofibers grafted with acridon-2-yl-alanine 接枝阿克啶-2-酰丙氨酸的蓝色荧光纤维素纳米纤维
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-24 DOI: 10.1016/j.carpta.2025.100917
Yuto Ito , Daisuke Sato , Noriko Kanai , Azusa Kikuchi , Izuru Kawamura
{"title":"Blue-fluorescent cellulose nanofibers grafted with acridon-2-yl-alanine","authors":"Yuto Ito ,&nbsp;Daisuke Sato ,&nbsp;Noriko Kanai ,&nbsp;Azusa Kikuchi ,&nbsp;Izuru Kawamura","doi":"10.1016/j.carpta.2025.100917","DOIUrl":"10.1016/j.carpta.2025.100917","url":null,"abstract":"<div><div>Cellulose nanofibers (CNFs) are ecofriendly biopolymers with remarkable thixotropic properties and Pickering emulsification stability due to their native amphiphilicity. In this study, we successfully synthesized Acd-CNF by covalently binding acridon-2-yl-alanine (Acd) to TEMPO-oxidized CNF (TOCNF), imparting blue fluorescence while maintaining its aqueous properties. The modified Acd-CNF displayed blue fluorescence at 424–447 nm and exhibited rheological properties similar to TOCNF, with enhanced viscosity and gel-like behavior. Furthermore, Acd-CNF functioned as a fluorescent stabilizer in Pickering emulsions. Confocal laser scanning microscopy (CLSM) demonstrated its interfacial localization in oil-in-water Pickering emulsions, facilitating Förster resonance energy transfer (FRET) to Nile Red-stained oil. Unlike conventional dyes prone to nonspecific adsorption, Acd-CNF enables direct fluorescence observation of CNFs, offering a reliable approach for emulsion microimaging. The modification enhances emulsion visualization and water dispersion behavior, broadening CNFs’ applications in fluorescence-based micro imaging and traceability.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100917"},"PeriodicalIF":6.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-performance azithromycin delivery via chitosan-tryptophan modified polyethersulfone transdermal membranes 壳聚糖-色氨酸改性聚醚砜透皮膜高效递送阿奇霉素
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-24 DOI: 10.1016/j.carpta.2025.100911
Mahya Samari , Soheila Kashanian , Sirus Zinadini , Hossein Derakhshankhah
{"title":"High-performance azithromycin delivery via chitosan-tryptophan modified polyethersulfone transdermal membranes","authors":"Mahya Samari ,&nbsp;Soheila Kashanian ,&nbsp;Sirus Zinadini ,&nbsp;Hossein Derakhshankhah","doi":"10.1016/j.carpta.2025.100911","DOIUrl":"10.1016/j.carpta.2025.100911","url":null,"abstract":"<div><div>This study investigates a novel asymmetric polyethersulfone (PES) membrane incorporated with chitosan-tryptophan (CS-W) for enhanced azithromycin delivery <em>in vitro</em> and <em>ex vivo</em>. Key fabrication parameters, including drug concentration (500 mg/L), membrane thickness (300 μm), modifier percentage (1.5 %), polymer percentage (17 %), and pore maker content (2 %), were optimized to improve membrane performance.</div><div>The optimized CS-W membrane (M4) achieved a drug release of 407 mg/L, compared to 240 mg/L for the unmodified membrane (M1), using a 500 mg/L azithromycin solution. Cell viability reached ∼80 %, and hemolysis was ∼4.6 %, confirming biocompatibility. The water vapor transmission rate increased by 9.25 %, supporting enhanced moisture handling. Long-term testing confirmed membrane reusability. Also the evaluations showed acceptable antibacterial activity.</div><div>The improved performance results from the membrane’s asymmetric structure: a dense top layer ensures sustained release, while a porous sub-layer acts as a drug reservoir. The drug release followed a zero-order kinetic model, making the membrane a promising candidate for sustained drug delivery applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100911"},"PeriodicalIF":6.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic nanoparticle as a new cutting-edge drug delivery and diagnostic platform: a review on its properties, synthesis, surface modification and applications 磁性纳米颗粒作为一种新的尖端药物传递和诊断平台:其性质、合成、表面改性和应用综述
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-24 DOI: 10.1016/j.carpta.2025.100905
Amrita Das , Prateep Sengupta , Jasmina Khanam , Robin Augustine , Avnesh S. Thakor , Sabu Thomas , Sudeep Roy , Kajal Ghosal
{"title":"Magnetic nanoparticle as a new cutting-edge drug delivery and diagnostic platform: a review on its properties, synthesis, surface modification and applications","authors":"Amrita Das ,&nbsp;Prateep Sengupta ,&nbsp;Jasmina Khanam ,&nbsp;Robin Augustine ,&nbsp;Avnesh S. Thakor ,&nbsp;Sabu Thomas ,&nbsp;Sudeep Roy ,&nbsp;Kajal Ghosal","doi":"10.1016/j.carpta.2025.100905","DOIUrl":"10.1016/j.carpta.2025.100905","url":null,"abstract":"<div><div>MNPs have extensive array of healthcare utilization, like targeted drug delivery, magnetic resonance imaging (MRI), hyperthermia therapy, and biosensing. The review paper aims to perform an in-depth detailing of MNPs as a therapeutic and diagonostic platform. The article discusses fundamental law governing magnetic targeting and explores most widely used synthesis methods like precipitation, co-precipitation, thermal decomposition, and green synthesis. It encompasses significant features of MNPs including surface chemistry and functionalization with various functional agents, such as polymer, bioactive molecules, inorganic metals and oxide and organic surfactant. Studies have found that coated MNPs are more biocompatible and protects it from quick elimination. It also highlights current researches for different applications of MNPs along with the commercially available magnetic products. It draws attentions to current challenges and future directions in the field of MNPs. All the current investigations summarized in the present review article has shown the potential of MNPs in personalized medicine with advancement in eco-friendly synthesis and surface functionalization ability.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100905"},"PeriodicalIF":6.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrodia elata polysaccharides: A comprehensive review of extraction, purification, characterization, structure-activity relationship and quality control applications 天麻多糖的提取、纯化、表征、构效关系及质量控制应用综述
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100909
Xinqin Kong , Zijia Zhang , Jiangyan Huo , Ningxin Li , Xinrui Yang , Huali Long , Yang Zhou , Jinjun Hou , Wanying Wu , De-an Guo
{"title":"Gastrodia elata polysaccharides: A comprehensive review of extraction, purification, characterization, structure-activity relationship and quality control applications","authors":"Xinqin Kong ,&nbsp;Zijia Zhang ,&nbsp;Jiangyan Huo ,&nbsp;Ningxin Li ,&nbsp;Xinrui Yang ,&nbsp;Huali Long ,&nbsp;Yang Zhou ,&nbsp;Jinjun Hou ,&nbsp;Wanying Wu ,&nbsp;De-an Guo","doi":"10.1016/j.carpta.2025.100909","DOIUrl":"10.1016/j.carpta.2025.100909","url":null,"abstract":"<div><div><em>Gastrodia elata</em> Blume (<em>G. elata</em>) has been utilized as homologous origin in medicine and food for over 2000 years. <em>Gastrodia elata</em> polysaccharides (GEP), the key bioactive components, have attracted increasing attention owing to their natural origin, potent bioactivities and low toxicity. Despite significant progress, multiple critical issues still need to be addressed. Current studies often summarize structural characterization and activities separately, with limited focus on advanced structures and structure-activity relationships. Moreover, the insufficient emphasis of GEP in the quality control of <em>G. elata</em> in the current pharmacopoeia has led to persistent challenges, including batch variability and lack of standardization of GEP. This review systematically summarizes recent advancements in the extraction, purification, and structural characterization of GEP, specifically to summarize the advanced structure of GEP and to introduce new techniques for structural elucidation. While we highlight relationships between structures and activities, and discuss their potential role in improving <em>G. elata</em> quality control. Looking forward, a dual chemical-biological quality control framework is proposed, alongside multidisciplinary approaches such as metabolomics, synthetic biology, and artificial intelligence (AI) to promote standardized production and clinical translation of GEP, thereby facilitating their broader application in medicine and functional foods.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100909"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodegradation mechanism of cellulose, hemicellulose, and lignin in bacteria-dominant aerobic composting from agricultural biomass waste:A review 纤维素、半纤维素和木质素在细菌主导的农业生物质废弃物好氧堆肥中的降解机理研究进展
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100879
Qin Gao , Li-na Guo , Shu-heng Li , Wang Wu , Jia wei Ding , Hong-jun Xu , Chao-bing Luo , Jun Li , De-qiang Li , Zun-qi Liu
{"title":"Biodegradation mechanism of cellulose, hemicellulose, and lignin in bacteria-dominant aerobic composting from agricultural biomass waste:A review","authors":"Qin Gao ,&nbsp;Li-na Guo ,&nbsp;Shu-heng Li ,&nbsp;Wang Wu ,&nbsp;Jia wei Ding ,&nbsp;Hong-jun Xu ,&nbsp;Chao-bing Luo ,&nbsp;Jun Li ,&nbsp;De-qiang Li ,&nbsp;Zun-qi Liu","doi":"10.1016/j.carpta.2025.100879","DOIUrl":"10.1016/j.carpta.2025.100879","url":null,"abstract":"<div><div>The conversion of abundantly produced agricultural waste has been the bottleneck and research hotspot in the development of the agricultural economy. Composting has been a sustainable treatment method for agricultural-sourced waste, in which aerobic fermentation promotes the decomposition of organic matter into stable humus and provides nutrients for plants. Due to the complex interactions among cellulose, hemicellulose, and lignin, the degradation of biomass during composting remains challenging. The aerobic fermentation relies on the interaction of various enzymes, which gradually cleavaged macromolecules into micromolecules or oligomers through a series of oxidation and hydrolysis processes, concurrently providing the nutrients needed for microbial growth, ultimately degrading lignocellulose. Generally speaking, the degradation efficiency of lignocellulose by fungi is higher than that by bacteria. However, fungi are sensitive to temperature, have poor adaptability to extreme environments, and have a long composting cycle. Therefore, this review mainly summarizes aerobic composting dominated by bacteria and clarifies the biodegradation mechanism of lignocellulose, viz., the multi-scale understanding of the degradation mechanism of lignocellulose. The dominant bacteria (e.g., <em>Bacillus, Pseudomonas, Rhodococcus, Enterobacter, Paenibacillus, Acinetobacter, Xantomonas, Aeromonas</em>, and <em>Pseudomonas</em>) and actinomycetes (e.g., <em>Micromonospora, Thermomonospora, Nocardia</em>, and <em>Streptomyces</em>) can be employed to develop efficient bacterial agents that consequently increase the degradation rate of lignocellulose and promote the harmless, resource utilization, and high-value utilization of agricultural waste.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100879"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a dual-phase solubilization system based on Hydroxypropyl-β-cyclodextrin /Eudragit® EPO for enhancing the dissolution of curcumin 基于羟丙基-β-环糊精/Eudragit®EPO的双相增溶体系的开发,以增强姜黄素的溶解
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100907
Minghui Hao , Chungang Zhang , Ti Wang , Fantong Yu
{"title":"Development of a dual-phase solubilization system based on Hydroxypropyl-β-cyclodextrin /Eudragit® EPO for enhancing the dissolution of curcumin","authors":"Minghui Hao ,&nbsp;Chungang Zhang ,&nbsp;Ti Wang ,&nbsp;Fantong Yu","doi":"10.1016/j.carpta.2025.100907","DOIUrl":"10.1016/j.carpta.2025.100907","url":null,"abstract":"<div><h3>Objective</h3><div>This research aims to establish a dual-phase solubilization system for curcumin by combining solid dispersion technology with cyclodextrin inclusion technology, in order to improve the dissolution of curcumin.</div></div><div><h3>Methods</h3><div>A composition of curcumin containing Eudragit® EPO (EPO) and Hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared using the solvent method, with the dissolution rate serving as the criterion for identifying the optimal formulation. The mechanism underlying this composition was analyzed through molecular docking, which were later corroborated using Fourier transform infrared spectroscopy (FTIR). Furthermore, various characterization techniques including scanning electron microscopy (SEM), polarized light microscopy (PLM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were employed to examine the characteristics of the curcumin composition.</div></div><div><h3>Results</h3><div>The investigations on dissolution revealed that the optimal formulation consists of curcumin:EPO:HP-β-CD in a ratio of 1:5:2, achieving an impressive 100 %. Molecular docking suggested that the incorporation of EPO enhances the interaction between curcumin and HP-β-CD, thereby stabilizing the system and facilitating improved dissolution. Characterization results affirmed that the composition is present in an amorphous form.</div></div><div><h3>Conclusion</h3><div>The synergistic use of EPO and HP-β-CD significantly enhanced the dissolution rate of curcumin, thereby potentially facilitating its clinical application.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100907"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application 将高岭土nanotubes@malva萃取物加入含有碳量子点的淀粉-透明质酸纳米复合膜中用于抗菌
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100906
Mahmoud Abbaszadeh , Nasser Arsalani , Fahimeh Kazeminava , Amin Mahoutforoush
{"title":"Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application","authors":"Mahmoud Abbaszadeh ,&nbsp;Nasser Arsalani ,&nbsp;Fahimeh Kazeminava ,&nbsp;Amin Mahoutforoush","doi":"10.1016/j.carpta.2025.100906","DOIUrl":"10.1016/j.carpta.2025.100906","url":null,"abstract":"<div><div>Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed &gt;90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100906"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shear-thinning dynamics and viscoelasticity of a novel Eremurus spectabilis glucomannan: Structural insights and implications for food/pharmaceutical applications 一种新型葡萄甘露聚糖的剪切变薄动力学和粘弹性:结构见解和对食品/制药应用的影响
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100910
Zahra Hoseinpour , Razieh Niazmand , Mahmut Ekrem Parlak , Mojtaba Heydari-Majd , Furkan Türker Saricaoglu
{"title":"Shear-thinning dynamics and viscoelasticity of a novel Eremurus spectabilis glucomannan: Structural insights and implications for food/pharmaceutical applications","authors":"Zahra Hoseinpour ,&nbsp;Razieh Niazmand ,&nbsp;Mahmut Ekrem Parlak ,&nbsp;Mojtaba Heydari-Majd ,&nbsp;Furkan Türker Saricaoglu","doi":"10.1016/j.carpta.2025.100910","DOIUrl":"10.1016/j.carpta.2025.100910","url":null,"abstract":"<div><div>This study aimed to isolate, purify, and characterize the principal water-soluble polysaccharide (ESRP) from <em>E. spectabilis</em> roots and evaluate its structural, thermal, emulsifying, and rheological properties. ESRP exhibited notable in vitro phenolic content and DPPH radical scavenging abilities. Thermal analysis via DSC revealed superior thermal stability, while FT-IR analysis indicated the presence of β-pyranose configuration in its main polysaccharide backbone. GC–MS and analyse revealed a composition of <span>d</span>-<em>glucose</em> (42.77 %), <span>d</span>-<em>mannose</em> (52.82 %), and <span>d</span>-<em>galactose</em> (4.43 %) and presence of degree of O-acetyl groups with a molecular weight of 19.1 kDa. The Zeta potential was negative (–20.97 mV), indicating an anionic nature of ESRP. The aqueous ESRP solutions showed shear thinning behaviour, with viscosity dependent on concentration and temperature. ESRP solutions exhibited pseudo-plastic properties, with lower moduli values compared to inulin. Overall, these findings suggest that ESRP, as a shear-thinning substance, has potential as a novel stabilizer or thickener in various industrial applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100910"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanofibrous scaffolds based on polyelectrolyte complexes of chitosan-alginate-COLLAGEN and chitosan-hyaluronic acid for tissue Engineering 基于壳聚糖-海藻酸-胶原和壳聚糖-透明质酸多电解质复合物的组织工程纳米纤维支架
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100915
Clarissa Ciarlantini , Rosa Barranco Garcia , Elisabetta Lacolla , Iolanda Francolini , Marta Fernández-García , Carolina Muñoz Nuñez , Alexandra Muñoz Bonilla , Antonella Piozzi
{"title":"Nanofibrous scaffolds based on polyelectrolyte complexes of chitosan-alginate-COLLAGEN and chitosan-hyaluronic acid for tissue Engineering","authors":"Clarissa Ciarlantini ,&nbsp;Rosa Barranco Garcia ,&nbsp;Elisabetta Lacolla ,&nbsp;Iolanda Francolini ,&nbsp;Marta Fernández-García ,&nbsp;Carolina Muñoz Nuñez ,&nbsp;Alexandra Muñoz Bonilla ,&nbsp;Antonella Piozzi","doi":"10.1016/j.carpta.2025.100915","DOIUrl":"10.1016/j.carpta.2025.100915","url":null,"abstract":"<div><div>Synthetic extracellular matrices have great potential for regenerative medicine. Among various scaffolding techniques, electrospinning has gained increasing interest in tissue engineering. Here, biomimetic nanofibrous scaffolds based on polyelectrolyte complexes consisting of chitosan (CS) and alginate (AL) or CS and hyaluronic acid (HA) at different concentrations were fabricated. Poly(vinyl alcohol) (PVA) was used as a fluid viscosity modulating agent. To improve the structural stability of the systems, the electrospun scaffolds were cross-linked using freeze-thaw processes and ethyl-dimethyl-aminopropyl carbodiimide (EDC) and N‑hydroxy-succinimide (NHS). Furthermore, the CS-AL scaffold was treated with different amounts of collagen to make it biomimetic. The collagen-containing matrices showed high thermal (T<sub>D</sub> increase of &gt;10 °C) and structural stability (swelling ratio 1.5–1.9). In contrast, HA-based matrices exhibited more homogeneous fibers (190–250 nm) and larger pore size (6–9 µm), but lower mechanical strength (0.5–1.1 GPa) and more swelling in water. Finally, it was verified that the electrospun scaffolds tested showed cell viability increased as the amount of collagen increased up to 85 %, whereas for scaffolds containing a high amount of HA, it decreased (71 %). However, the sample containing the lowest HA concentration exhibited a morphology more suitable for interaction with cells, demonstrating great potential in tissue engineering applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100915"},"PeriodicalIF":6.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biogenic synthesis of lipopolysaccharide facilitated silver nanoparticles (LPS-AgNPs) and its molecular mechanisms against systemic pathogens MRSA and Salmonella typhi, an in-vitro and in-vivo based approach 脂多糖促进银纳米颗粒(LPS-AgNPs)的生物合成及其对抗全身性病原体MRSA和伤寒沙门氏菌的分子机制——体外和体内研究
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI: 10.1016/j.carpta.2025.100912
Deepthi Ramya Ravindran , Suganya Kannan , Vimala Devi Veeranan , Shanmugaiah Vellasamy
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