{"title":"将高岭土nanotubes@malva萃取物加入含有碳量子点的淀粉-透明质酸纳米复合膜中用于抗菌","authors":"Mahmoud Abbaszadeh , Nasser Arsalani , Fahimeh Kazeminava , Amin Mahoutforoush","doi":"10.1016/j.carpta.2025.100906","DOIUrl":null,"url":null,"abstract":"<div><div>Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed >90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100906"},"PeriodicalIF":6.5000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application\",\"authors\":\"Mahmoud Abbaszadeh , Nasser Arsalani , Fahimeh Kazeminava , Amin Mahoutforoush\",\"doi\":\"10.1016/j.carpta.2025.100906\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed >90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.</div></div>\",\"PeriodicalId\":100213,\"journal\":{\"name\":\"Carbohydrate Polymer Technologies and Applications\",\"volume\":\"11 \",\"pages\":\"Article 100906\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbohydrate Polymer Technologies and Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666893925002476\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymer Technologies and Applications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666893925002476","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application
Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed >90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.
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