Carbohydrate Polymer Technologies and Applications最新文献

{"title":"Spray-drying encapsulation of sunflower pollen peptides using carbohydrate polymers: Physicochemical, antioxidant, structural and morphological analysis","authors":"Amir Akbarmehr ,&nbsp;Seyed Hadi Peighambardoust ,&nbsp;Leila Pourhasan ,&nbsp;Khashayar Sarabandi","doi":"10.1016/j.carpta.2024.100622","DOIUrl":"10.1016/j.carpta.2024.100622","url":null,"abstract":"<div><div>Flower pollen collected by honey bees is a rich source of bioactive peptides (BPs). Different carriers such as maltodextrin (MD), gum Arabic (GA), and β-cyclodextrin (βCD) and their combinations were used for encapsulation of BPs from sunflower pollen protein (SPP). Different physicochemical, antioxidant, functional, structural and morphological properties of the obtained microparticles were evaluated. The amino acid composition of SPP and the derived peptides revealed a high proportion of hydrophobic (∼40%), antioxidant (∼18%), and essential (∼31%) amino acids, indicating their biological potential. Among the microencapsulated samples, the MD-βCD composition exhibited the highest production efficiency (∼65%) and improved physicochemical properties, such as microbial stability, density, flowability, wettability, and solubility, compared to the spray-dried free peptides (free SD-BPs) without a carrier. The encapsulation process helped to maintain the structural integrity of the microparticles and reduced moisture absorption. The SPP-derived peptides encapsulated in MD-βCD also demonstrated potent antioxidant activity, inhibiting ABTS⁺ (∼75%) and DPPH^- (∼69%) free radicals. The results suggest that the BPs obtained from sunflower pollen can be a valuable ingredient for enriching various food products due to their favorable nutritional, functional, and antioxidant properties.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100622"},"PeriodicalIF":6.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring cationic amylose inclusion complexes as a pioneering carrier for aroma molecules; fabrication, and characterization","authors":"Zohreh Mokhtari ,&nbsp;Seid Mahdi Jafari","doi":"10.1016/j.carpta.2024.100615","DOIUrl":"10.1016/j.carpta.2024.100615","url":null,"abstract":"<div><div>Amylose complexes are considered excellent carriers for flavor compounds (FCs), leading to their controlled release. Nevertheless, the utilization of native amylose for the creation of inclusion complexes (ICs) is constrained by its pronounced propensity for retrogradation (re-crystallization) and its limited water solubility. Therefore, chemical modification of amylose stands as an innovative approach to generate soluble ICs. This study focused on generating and evaluating ICs composed of cationic amylose sourced from sago and corn, which then loaded with FCs (menthol, thymol, and eugenol). The characteristics of ICs with FCs were characterized in terms of including X-ray diffraction (XRD), Complex Index, Fourier transform infrared/Raman spectroscopy, and scanning electron/atomic force microscopy. The XRD and the complex index findings suggested that cationizing the anhydroglucose units of amylose was accomplished without disrupting its helical structure, while also showing a promising ability to create ICs. Notably, sago amylose exhibited a significantly higher complex index compared to corn amylose (<em>p</em> &lt; 0.05). Morphological analysis of the cationized amylose-flavor ICs revealed the presence of spherical and lamellar crystalline structures, suggesting a well-organized assembly resulting from ICs. Also, due to its high hydrophobicity and low vapor pressure, menthol in the presence of ethanol was able to form more ICs with amylose compared to thymol and eugenol. Finally, the study highlighted the unique properties of sago amylose, including its high retrogradation tendency, which was further enhanced by cationization. These findings underscore the utility of cationized amylose, particularly from sago, as an advanced material for encapsulating hydrophobic compounds.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100615"},"PeriodicalIF":6.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of regenerated cellulose fibres by cork-derived suberin and the cutin fraction from grape skins","authors":"Kaniz Moriam ,&nbsp;Catarina Azevedo ,&nbsp;Sara Fateixa ,&nbsp;Fábio Bernardo ,&nbsp;Herbert Sixta ,&nbsp;Dmitry V. Evtuguin","doi":"10.1016/j.carpta.2024.100613","DOIUrl":"10.1016/j.carpta.2024.100613","url":null,"abstract":"<div><div>Regenerated cellulose fibres from dissolving pulp are a versatile alternative to cotton fibres on the path to the sustainable textile industry. In this study, cellulose fibres obtained by the Ioncell-F® process (Ioncell fibres) were modified by adding 10 % (w/w) of suberin compounds isolated from cork (SUB) or a cutin fraction from grape skins (CUT) in the spinning dope. Although both SUB and CUT modified fibres revealed higher hydrophobicity than unmodified fibres, fibres doped with CUT showed better waterproof performance than those doped with SUB. This was explained by the better retention of CUT than SUB on the regenerated fibres and by the higher hydrophobicity of CUT. Differences in the strength properties of Ioncell fibres obtained by pilot-scale dry-jet wet spinning were related to their physical structure, whereas dirt repellence and susceptibility to enzymatic hydrolysis depended on the occurrence and amounts of retained CUT or SUB.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100613"},"PeriodicalIF":6.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxymethyl chitosan oligosaccharide enzymatic hydroxylates with reactive oxygen species scavenging and anti-inflammatory activity for topical treatment of skin photodamage","authors":"Ziming Zhu ,&nbsp;Hui Li ,&nbsp;Xiansen Lv ,&nbsp;Yan Yang ,&nbsp;Baoqin Han ,&nbsp;Zhiwen Jiang","doi":"10.1016/j.carpta.2024.100612","DOIUrl":"10.1016/j.carpta.2024.100612","url":null,"abstract":"<div><div>Skin photodamage caused by ultraviolet (UV) radiation is a major public health concern. UVB rays penetrate the epidermis, inducing oxidative stress and compromising essential cellular components. The demand for natural ingredients with properties such as moisturization, anti-inflammatory effects, antioxidant protection, and compatibility is increasing to combat the impact of photodamage on the skin. Herein, the carboxymethyl chitosan oligosaccharide (CM-COS) enzymatic hydroxylates were used on the topical application of skin photodamage for the first time. CM-COS, the degradation product of carboxymethyl chitosan, has high water solubility and multiple biological activities. Results showed that CM-COS promoted human epidermal cell (HaCaT) migration without causing cytotoxicity. In photodamaged HaCaT cells, CM-COS maintained cell viability and cytoskeletal integrity while inhibiting reactive oxygen species accumulation, apoptosis, and cell cycle arrest. CM-COS regulates gene expression related to cell cycle, oxidative stress, and inflammation in UVB-radiated HaCaT based on transcriptomic and qPCR data. In UVB-exposed mice, topical treatment of CM-COS significantly alleviated redness and scab formation and increased the moisture content of photodamaged skin. Histological analyses revealed reduced epidermal thickness and increased collagen I and collagen III deposition in photodamaged skin following CM-COS treatment. Additionally, gene expression related to the cell cycle, extracellular matrix, and inflammation were significantly activated by CM-COS based on transcriptomic and qPCR data. CM-COS modulated the levels of collagen and inflammation-related proteins. Collectively, the data confirm the therapeutic effect of CM-COS against skin photodamage and highlight the potential of natural marine oligosaccharides for treating skin diseases such as aging, wounds, and burns.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100612"},"PeriodicalIF":6.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-based multimodal polymeric nanoparticles targeting pancreatic β-cells","authors":"Lorenzo Rossi ,&nbsp;Cataldo Pignatelli ,&nbsp;Krisztina Kerekes ,&nbsp;Francesca Cadamuro ,&nbsp;András Dinnyés ,&nbsp;Felix Lindheimer ,&nbsp;Jochen Seissler ,&nbsp;Magdalena Lindner ,&nbsp;Sibylle Ziegler ,&nbsp;Peter Bartenstein ,&nbsp;Yi Qiu ,&nbsp;Judit Kovács-Kocsi ,&nbsp;Zoltán Körhegyi ,&nbsp;Magdolna Bodnár ,&nbsp;Erika Fazekas ,&nbsp;Eszter Prépost ,&nbsp;Francesco Nicotra ,&nbsp;Laura Russo","doi":"10.1016/j.carpta.2024.100610","DOIUrl":"10.1016/j.carpta.2024.100610","url":null,"abstract":"<div><div>Multimodal in vivo imaging of pancreatic islets might improve monitoring of endocrine grafts upon implantation, helping clinical validation of new regenerative therapies based on the replacement of β-cells in type 1 diabetes affected patients. Herein, the generation of chitosan-based multimodal diagnostic nanoparticles (NPs) able to target β-cells is described. The NPs, composed of chitosan (CH) and γ-poly-glutamic-acid (γ-PGA) with different “clickable” functional groups were chemoselectively decorated at the surface with Exendin-4 (Ex4), a ligand of glucagon-like peptide 1 (GLP-1) β-cell receptors, and with a DOTA containing linker, to chelate diagnostic radioisotopes. Furthermore, the NPs were conjugated with IRDye®800CW for multispectral optoacoustic tomography (MSOT). The affinity of Ex4 decorated NPs towards GLP-1R was confirmed by competitive flow cytometry tests. The detectability of the NPs labeled with IRDye®800CW and Ex4 in MSOT experiments was demonstrated. In vivo biodistribution of Ex4 decorated NPs labelled with Ga-68 was studied with positron emission tomography (PET) experiments in mice. Specific binding to GLP-1 receptor expressing tissue was demonstrated in autoradiography experiments, showing potential of the multimodal NPs for specifically targeting β-cells.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100610"},"PeriodicalIF":6.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Lithium onto chitosan derivative using Taguchi method","authors":"Peter Osei Boamah ,&nbsp;Jacqueline Onumah ,&nbsp;Tayari Salifu ,&nbsp;John Hendrick Essel ,&nbsp;Benjamin Apam","doi":"10.1016/j.carpta.2024.100611","DOIUrl":"10.1016/j.carpta.2024.100611","url":null,"abstract":"<div><div>This study aimed to remove lithium from a water-based mixture using a low molecular weight chitosan derivative (LMWCHT-LA-GLA). Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and Nuclear Magnetic Resonance (NMR) spectroscopy were used to assess the sorbent. Lithium sorption capabilities were enhanced by LMWCHT-LA-GLA's functional groups OH, NH₂, and COOH. The initial concentration, sorbent dosage and pH had the biggest effects on sorption efficiency. At the ideal initial lithium content of 1 mg/L, sorbent quantity of 0.10 g and solution pH of 6, the percentage of removal was 62.75 %. The analysis of variance (ANOVA) revealed that the initial lithium concentration contributed the largest percentage (94.10 %) to the removal efficiency. Utilizing the Freundlich, Temkin and Langmuir sorption models, the experimental data were examined. The experimental data and the Langmuir isotherm agreed fairly well with a maximum sorption capacity of 7.00 mg/g. Pseudo-first- and pseudo-second-order kinetic models were used to analyze the kinetic data obtained at the optimal initial concentration. The pseudo-second-order model provided a good fit to the experimental data. Thermodynamic studies were used to determine the kind of lithium sorption. Overall results suggested that LMWCHT-LA-GLA is a promising sorbent for the removal of lithium from aqueous solution.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100611"},"PeriodicalIF":6.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of consumption of unsaturated alginate oligosaccharides on the gut microbiota and the intestinal mucosal immunity homeostasis in immunocompromised mice","authors":"Zhaopeng Shen ,&nbsp;Hua Yin ,&nbsp;Lu Sun ,&nbsp;Lu Chen ,&nbsp;Jiandong Li ,&nbsp;Xin Zhang ,&nbsp;Mingyong Zeng ,&nbsp;Xiaolu Jiang ,&nbsp;Junhong Yu","doi":"10.1016/j.carpta.2024.100604","DOIUrl":"10.1016/j.carpta.2024.100604","url":null,"abstract":"<div><div>Despite the well-known health benefits of unsaturated alginate oligosaccharides (UAOS), limited information exists on how they regulate the gut microbiota and intestinal mucosal immunity. In this study, UAOS was produced by alginate lyase degradation. Fourier transform infrared (FTIR), mass spectrometry (MS), and nuclear magnetic resonance (NMR) analyses showed that UAOS primarily consists of oligosaccharides, mainly pentamers, with a G/M ratio of 1.44 and unsaturated double bonds at the non-reducing end. UAOS exhibited good prebiotic effects; increased beneficial intestinal bacteria; improved the diversity, structure, and composition of the gut microbiota; and promoted the production of SCFAs. In particular, UAOS significantly increased the abundance of butyrate levels and their producing microbiota, such as <em>Lachnospiraceae, Alloprevotella</em>, and <em>Butyicicoccus</em>. Moreover, orally administered UAOS alleviated intestinal mucosal immunosuppression by upregulating the levels of the tight junction proteins occludin and ZO-1, enhancing the intestinal biochemical and immune barrier function by increasing levels of mucin-2 and SIgA, upregulating the CD4+/CD8+ ratio, regulating CD4+ <em>T</em> cell differentiation, and stimulated immune cytokine secretion and transcription factor production (T-bet/GATA-3). This process was related to TLR4/MyD88/NF-κB pathway. In summary, UAOS effectively regulates intestinal mucosal immune homeostasis by strengthening the intestinal barrier and regulating the intestinal microbiota and intestinal butyrate levels. Therefore, UAOS acts as a prebiotic and immune stimulator to improve host health.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100604"},"PeriodicalIF":6.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel chemical approach for the development of thioesterified cellulose derivatives","authors":"Md. Sadiqul Islam Sheikh ,&nbsp;Muhammed Shah Miran,&nbsp;Md. Abu Bin Hasan Susan,&nbsp;Md. Mominul Islam","doi":"10.1016/j.carpta.2024.100608","DOIUrl":"10.1016/j.carpta.2024.100608","url":null,"abstract":"<div><div>In this study, thioesterified cellulose was synthesized by grafting thiol moiety onto <em>α</em>-cellulose, which was first oxidized with different reactive oxygen species such as H₂O₂, Fenton reagent (FR), and peroxyacetic acid in aqueous solution. The thioesterification was done by refluxing oxidized cellulose with ethanedithiol in a mixture of toluene and water (4:1) at 85°C for 6 h. The modification of cellulose was evidenced by FTIR, Raman, solid-state ¹³C CP MAS NMR spectroscopy, conductometric titration, thermogravimetric analysis, X-ray diffraction, zeta potential measurement, molecular weight determination, and SEM analysis. The characteristic absorption bands for −C=O and −C(=O)−S− bonds in FTIR and Raman spectra were suggestive of the modification of cellulose. 20 % FR was the most efficient in introducing the highest amount (158.93 μmol g⁻¹) of the -COOH groups, while cleavage of cellulose backbone was found to take place as evidenced by the result of the degree of polymerization. The presence of new peaks in ¹³C CP MAS NMR spectra of thiol-functionalized cellulose ascertained the anchoring of thiol onto oxidized cellulose. Additionally, the significant decrease in the C6 signals for the amorphous region of thiol-modified cellulose provided information about successful modification. In addition, the degree of substitution was determined to be about 0.025. The efficacious functionalization was further supported by the measurement of zeta potential, wherein thioesterified cellulose exhibited the highest negative zeta potential due to increased hydrophobicity. This study would open up a new route for the development of important derivatives of cellulose, including cellulose dimer, containing the thioester group which is the backbone of many antibiotics and natural products.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100608"},"PeriodicalIF":6.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of cellulose nanocrystals from the waste banana (M. oranta) tree rachis fiber as a reinforcement to fabricate useful bionanocomposite","authors":"Md. Mahmudur Rahman ,&nbsp;Md. Elius Hosen Pk ,&nbsp;Md. Waliullah ,&nbsp;Md. Ismail Hossain ,&nbsp;Mohd. Maniruzzaman ,&nbsp;Bijoy Chandra Ghos","doi":"10.1016/j.carpta.2024.100607","DOIUrl":"10.1016/j.carpta.2024.100607","url":null,"abstract":"<div><div>It is crucial to produce CNCs from the waste biomass of secondary plants to reduce the extra pressure on primary plants which have other advantageous applications in many sectors. Whereas the useless banana (<em>M. oranta</em>) rachis after harvesting its edible part could be a very new and beneficial one. Meanwhile, several well-known methods could be conducted, namely water retting, scouring, alkali treatment, chlorite bleaching, and acid hydrolysis, to yield high-quality CNCs. The samples of all stages were characterized by several state-of-the-art techniques, namely FTIR-ATR, TGA, FESEM, XRD, UV–vis-NIR, DLS, and zeta potential analysis, for a better understanding of their structural properties/purity. However, obtained results recommended that the CNCs have shown extensive active edges, greater thermal improvement up to 700 °C, high crystallinity around 81.07±0.15% with JCPDS-ICDD card number (00-056-1718), a honeycomb-like porous microstructure, and promising spherical shapes along with an average size around 50 nm. Additionally, the newly produced CNCs were free from all impurities and coloring materials and revealed a higher negatively charged surface around -45 mV. Therefore, due to these outstanding features, banana rachis CNCs with a high yield (around 82.05±0.06%) would be beneficially used as promising reinforcement to fabricate useful bionanocomposite for various applications to replace fossil-based hazardous synthetic materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100607"},"PeriodicalIF":6.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbranched polylysine/oxidized carboxymethyl cellolose integrated gelatin composite for wound treatment","authors":"Fatemeh Hakimi ,&nbsp;Moein Kosari ,&nbsp;Parya Esmaeelnejad ,&nbsp;Shabnam Sattari ,&nbsp;Fahimeh Kazeminava ,&nbsp;Sheida Moradi ,&nbsp;Motaleb Ghasemian ,&nbsp;Mohsen Adeli ,&nbsp;Zainab Ahmadian","doi":"10.1016/j.carpta.2024.100606","DOIUrl":"10.1016/j.carpta.2024.100606","url":null,"abstract":"<div><div>Herein, we report the preparation and evaluation of a new composite consisting of gelatin matrix, oxidized carboxymethyl cellulose (OCMC), and hyperbranched polylysine (PL) components for full-thickness wound treatment. To enhance the antimicrobial activity of the gelatin matrix, OCMC/PL was successfully combined with this matrix via the Schiff base reaction. Moreover, allantoin (Alla) as a drug model was loaded by this composite and the optimal formulation for wound healing (PLOCG-Alla) was obtained. The structural properties, thermal stability, crystallinity and interactions between materials were investigated using SEM, TGA, XRD and FTIR techniques. Cytotoxicity and antibacterial capacity were evaluated by MTT assay and colony counting methods, respectively. The release behavior was investigated at two different pH values. Blood coagulation and wound healing potential were also evaluated <em>in vivo</em>. PLOCG-Alla exhibited high antibacterial capacity, pH-dependent release behavior, biocompatibility and high blood clotting ability. It also accelerated wound healing <em>in vivo</em>.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"8 ","pages":"Article 100606"},"PeriodicalIF":6.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}