Carbohydrate Polymer Technologies and Applications最新文献

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Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-04-04 DOI: 10.1016/j.carpta.2025.100787
Puja Gangurde , Zahra Gounani , Jacopo Zini , Roberta Teixeira Polez , Monika Österberg , Patrick Lauren , Tatu Lajunen , Timo Laaksonen
{"title":"Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery","authors":"Puja Gangurde ,&nbsp;Zahra Gounani ,&nbsp;Jacopo Zini ,&nbsp;Roberta Teixeira Polez ,&nbsp;Monika Österberg ,&nbsp;Patrick Lauren ,&nbsp;Tatu Lajunen ,&nbsp;Timo Laaksonen","doi":"10.1016/j.carpta.2025.100787","DOIUrl":"10.1016/j.carpta.2025.100787","url":null,"abstract":"<div><div>Stimuli-responsive nanoparticles have gained attention for their ability to control drug release via external signals. However, challenges like biodegradation and toxicity hinder their applications. This study introduces a system by integrating light-activated liposomes with cellulose nanofiber (CNF) hydrogel, creating a controlled release system where liposomes act as drug reservoirs, protecting drug molecules and preventing unwanted cargo leakage for on-demand localized drug delivery. Our surface interaction study between cationic liposomes and nanocellulose shows that the liposomes, while not uniformly distributed, are bound to the nanocellulose hydrogel due to strong electrostatic interactions and fiber networks, thus forming a depot-like drug reservoir system.</div><div>We evaluated hydrogel thickness and light dose to optimize the cargo release. Upon activation with near-infrared light (808 nm, 1 W/cm<sup>2</sup>), the photosensitizer inside the bilayer of thermosensitive liposome generates heat, which makes liposome leaky, resulting in on-demand cargo release. We observed up to 50 % release at low dose (20 J/cm<sup>2</sup>) of light, which increased to 80 % after exposure to higher dose of light (80 J/cm<sup>2</sup>), highlighting the sensitivity of the system. This dual-platform combines the biocompatibility of nanocellulose with tunability of light-activated liposomes, presenting promising approach for on-demand drug delivery with significant potential for personalized medicine.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100787"},"PeriodicalIF":6.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable development of chitosan-gelatin composite films for food packaging using crude chitosan extracted from American lobster (Homarus americanus) shell waste
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-04-04 DOI: 10.1016/j.carpta.2025.100788
Abhinav Jain , Beth Mason , Marianne Su-Ling Brooks
{"title":"Sustainable development of chitosan-gelatin composite films for food packaging using crude chitosan extracted from American lobster (Homarus americanus) shell waste","authors":"Abhinav Jain ,&nbsp;Beth Mason ,&nbsp;Marianne Su-Ling Brooks","doi":"10.1016/j.carpta.2025.100788","DOIUrl":"10.1016/j.carpta.2025.100788","url":null,"abstract":"<div><div>In this study, crude chitosan extracted from American lobster shells (<em>Homarus americanus</em>) was used to develop bio-based films. These films were prepared using solvent casting at various drying temperatures (37, 60, and 80 °C) and enhanced by blending with sunflower oil and gelatin from fish skin. Structural and thermal analyses (FT-IR, XRD, and TGA) demonstrated excellent compatibility between the extracted chitosan and fish gelatin. A 1:1 blend of these biopolymers resulted in films with increased flexibility and reduced water vapor permeation compared to pure chitosan films. Adding 10 % (w/w polymer) sunflower oil improved surface hydrophobicity and reduced swelling without compromising strength. Higher drying temperatures increased swelling, stretchability, and opacity, but decreased tensile strength and vapor permeability. Films prepared at 80 °C exhibited the best elasticity (100.4 %) and the lowest vapor permeability (1.2 g.mm/kPa.h.m<sup>2</sup>) while maintaining adequate tensile strength (27 MPa). This study demonstrates a sustainable approach for developing chitosan-gelatin composite films using renewable marine processing byproducts. In particular, the applicability of crude chitosan extracted from waste lobster shells (without additional purification steps) as a cost-effective and sustainable feedstock is highlighted, offering an eco-friendly alternative to conventional plastic food packaging.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100788"},"PeriodicalIF":6.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of delignification and mercerization processes for high-purity cellulose extraction from Semantan bamboo (Gigantochloa scortechinii) using Response Surface Modelling
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-31 DOI: 10.1016/j.carpta.2025.100784
Jameelah Alhadi Salih Othman , R.A. Ilyas , Abu Hassan Nordin , Norzita Ngadi , M.F.M. Alkbir , Victor Feizal Knight , Mohd Nor Faiz Norrrahim
{"title":"Optimization of delignification and mercerization processes for high-purity cellulose extraction from Semantan bamboo (Gigantochloa scortechinii) using Response Surface Modelling","authors":"Jameelah Alhadi Salih Othman ,&nbsp;R.A. Ilyas ,&nbsp;Abu Hassan Nordin ,&nbsp;Norzita Ngadi ,&nbsp;M.F.M. Alkbir ,&nbsp;Victor Feizal Knight ,&nbsp;Mohd Nor Faiz Norrrahim","doi":"10.1016/j.carpta.2025.100784","DOIUrl":"10.1016/j.carpta.2025.100784","url":null,"abstract":"<div><div>Bamboo (<em>Gigantochloa scortechinii</em>) is increasingly recognized as an abundant, eco-friendly resource with immense potential in sustainable material development. Central to its utilization is the extraction of high-purity cellulose, a material prized for its exceptional strength, light weight, and biodegradability. This cellulose has broad applications in the production of nanocellulose, paper, adsorbents, textiles, and more. However, optimizing the delignification and mercerization processes for maximum cellulose yield and quality remains a challenge. This study aimed to optimize the delignification and mercerization processes to extract high-quality cellulose from bamboo fiber using Response Surface Methodology (RSM). The key parameters—sodium chlorite (NaClO₂) concentration (12–20 % w/w), temperature (60–80 °C), and reaction time (3–5 h)—were systematically varied to maximize cellulose yield and quality. The optimal conditions were found to be 16 % NaClO₂, 70 °C, and a 4-hour treatment, yielding 45.9 % cellulose. Structural analysis revealed an increase in crystallinity from 57.87 % in untreated fibers to 64.29 % in treated fibers, confirming the effectiveness of the optimized processes. These findings demonstrate the potential of Semantan bamboo for industrial applications, where high-purity cellulose is required.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100784"},"PeriodicalIF":6.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial and bioadhesive characteristics of mussel-inspired hyaluronic acid hydrogels encapsulated with sea urchin-shaped copper-coated silicon dioxide nanoparticles
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-30 DOI: 10.1016/j.carpta.2025.100781
Hye Jin Hong , Kihak Gwon , Gisang Park , Jeong-Hoon Yu , Seonhwa Lee , Jong-Sung Yu , Do Nam Lee
{"title":"Antibacterial and bioadhesive characteristics of mussel-inspired hyaluronic acid hydrogels encapsulated with sea urchin-shaped copper-coated silicon dioxide nanoparticles","authors":"Hye Jin Hong ,&nbsp;Kihak Gwon ,&nbsp;Gisang Park ,&nbsp;Jeong-Hoon Yu ,&nbsp;Seonhwa Lee ,&nbsp;Jong-Sung Yu ,&nbsp;Do Nam Lee","doi":"10.1016/j.carpta.2025.100781","DOIUrl":"10.1016/j.carpta.2025.100781","url":null,"abstract":"<div><div>The urgent need to mitigate the deadly effects of infectious diseases underscores the significance of incorporating antibacterial properties into wound-healing treatments. Hydrogel systems have gained substantial attention as wound-dressing patches owing to their superior fluid absorption, versatility in chemical and physical properties, capacity for biomolecule entrapment, and excellent biocompatibility. Many research efforts have focused on embedding antibacterial agents into hydrogel networks to develop effective and reliable wound-dressing solutions. Therefore, this study aims to investigate antibacterial and bioadhesive hydrogels crafted by embedding sea urchin-shaped copper-coated silicon dioxide nanoparticles (Cu@SiO<sub>2</sub>) into catechol-modified and photopolymerizable hyaluronic acid (HA) hydrogels. Inspired by marine mussels, whose foot proteins enable strong adhesion to various surfaces, we chemically modified materials with catechol groups to introduce bioadhesive properties. This modification was characterized using Nuclear Magnetic Resonance (NMR), Fourier-Transform Infrared (FT-IR), and Powder X-ray Diffraction (PXRD) spectroscopy. The bioadhesive strength of the modified surfaces was validated through lap-shear testing. Incorporating Cu@SiO<sub>2</sub> into the catechol-modified HA-based hydrogel enhanced their antibacterial activity and mechanical integrity. The bactericidal efficacy of the hydrogel was tested against three distinct bacterial strains, while its biocompatibility was evaluated using mouse embryonic fibroblasts (MEFs). These outstanding properties position the Cu@SiO<sub>2</sub>-hydrogel as a strong candidate for use in wound-dressing patches and other biomedical applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100781"},"PeriodicalIF":6.2,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dual antioxidant chitosan oligosaccharides regulate the transdifferentiation of lung effector cells in the management of idiopathic pulmonary fibrosis
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-28 DOI: 10.1016/j.carpta.2025.100782
Huan He, Youtao Xu, Xinru Chen, Jiawen Wu, Xianpeng Zhong, Xiyu Li, Jing Qiao
{"title":"The dual antioxidant chitosan oligosaccharides regulate the transdifferentiation of lung effector cells in the management of idiopathic pulmonary fibrosis","authors":"Huan He,&nbsp;Youtao Xu,&nbsp;Xinru Chen,&nbsp;Jiawen Wu,&nbsp;Xianpeng Zhong,&nbsp;Xiyu Li,&nbsp;Jing Qiao","doi":"10.1016/j.carpta.2025.100782","DOIUrl":"10.1016/j.carpta.2025.100782","url":null,"abstract":"<div><div>Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with limited treatment options. This study investigates the therapeutic potential of chitosan oligosaccharides (COS), a natural carbohydrate with antioxidant properties, in comparison to the FDA-approved drug pirfenidone (PFD). Both <em>in vivo</em> and <em>in vitro</em>, COS effectively alleviates IPF progression by inhibiting epithelial-mesenchymal transition and fibroblast-myofibroblast transition through a dual antioxidant mechanism. This mechanism combines direct reactive oxygen species (ROS) scavenging with nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated enhancement of endogenous defenses, disrupting the ROS-TGF-β1 feedback loop and preserving mitochondrial function. In bleomycin-induced IPF mice, COS significantly reduces collagen deposition by 73.33 % and restores superoxide dismutase activity to 65.30 % of control levels, outperforming PFD in mitigating oxidative stress. Importantly, COS exhibits no cytotoxicity at concentrations up to 3000 μg/mL, contrasting sharply with PFD's toxicity. These findings highlight COS's superior safety profile and therapeutic efficacy, positioning it as a promising candidate for clinical development. Future studies should explore its potential in other fibrotic diseases and investigate combinatorial therapies to maximize clinical impact. This work not only advances our understanding of COS's antifibrotic mechanisms but also lays the foundation for a new class of carbohydrate-based therapeutics targeting the root causes of fibrosis.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100782"},"PeriodicalIF":6.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the flexibility and thermal properties of polylactic acid/thermoplastic starch blends through selective plasticization
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-28 DOI: 10.1016/j.carpta.2025.100780
Maedeh Zamani , Mohammad Fasihi , Sajad Rasouli
{"title":"Enhancing the flexibility and thermal properties of polylactic acid/thermoplastic starch blends through selective plasticization","authors":"Maedeh Zamani ,&nbsp;Mohammad Fasihi ,&nbsp;Sajad Rasouli","doi":"10.1016/j.carpta.2025.100780","DOIUrl":"10.1016/j.carpta.2025.100780","url":null,"abstract":"<div><div>This study investigates the impact of polyethylene glycol (PEG) and dioctyl terephthalate (DOTP) as plasticizers on the mechanical, microstructural, thermal, and crystalline properties of polylactic acid/thermoplastic starch (PLA/TPS) blends. While plasticization reduced tensile and Izod impact strengths by 60 %, it significantly improved ductility and impact strength by 268 % when using DOTP and lower molecular weight PEG (LWPEG), due to their lubrication capabilities and decreased frictional forces between polymer chains. This facilitated easier disentanglement before the chains ruptured under the load. Morphological analysis revealed a well-dispersed droplet-matrix structure with smaller droplet sizes (22.41 ± 4.9 μm for DOTP and 20.98 ± 4.7 μm for LWPEG) compared to pure PLA/TPS (49.97 ± 14.3 μm). Differential scanning calorimetry (DSC) showed reduced glass transition, crystalline, and melting temperatures, with plasticizers migrating to the TPS phase, enhancing crystallinity. DOTP, in particular, promoted β-type crystal formation, improving Young's modulus, ductility, and impact strength. Overall, DOTP demonstrated superior plasticization effects, yielding the best droplet-matrix morphology and highest crystallinity, making it the most effective plasticizer for enhancing PLA/TPS properties.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100780"},"PeriodicalIF":6.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitin nanocrystals as bio-based adhesives for the development of sustainable cork composites
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-28 DOI: 10.1016/j.carpta.2025.100783
M.C. García-Laynez , M. Herrera , S.I. Molina , A. Sanz de León
{"title":"Chitin nanocrystals as bio-based adhesives for the development of sustainable cork composites","authors":"M.C. García-Laynez ,&nbsp;M. Herrera ,&nbsp;S.I. Molina ,&nbsp;A. Sanz de León","doi":"10.1016/j.carpta.2025.100783","DOIUrl":"10.1016/j.carpta.2025.100783","url":null,"abstract":"<div><div>In this work, we demonstrate the potential of chitin nanocrystals (ChNCs), a sustainable and biobased nanomaterial, as an adhesive for valorizing cork waste and fabricating fully biobased composites through compression molding. SEM and XCT analyses confirmed that, when used at concentrations below 30 wt.%, ChNCs integrate homogeneously with cork by adhering uniformly to the cork cell walls, preserving its low density and inherent flexibility. Notably, composites containing 20 wt.% of ChNCs achieved superior mechanical properties (i.e. flexibility, strength and toughness) compared to composites with paraffin over a broad concentration range (5–70 wt.%). Unlike paraffin, which increases density by filling the cork cells, ChNCs maintain the porous structure while significantly enhancing compressive performance. These findings highlight the exceptional adhesive and reinforcing capabilities of ChNCs, paving the way for their use as a natural binder in developing sustainable cork composites and extending this approach to other agrowaste materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100783"},"PeriodicalIF":6.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facile in situ synthesis of ZnO-infused caseinate/carboxymethyl cellulose films with antibacterial properties for cheddar cheese packaging
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-26 DOI: 10.1016/j.carpta.2025.100779
Bai Qu, Zhenlei Xiao, Yangchao Luo
{"title":"Facile in situ synthesis of ZnO-infused caseinate/carboxymethyl cellulose films with antibacterial properties for cheddar cheese packaging","authors":"Bai Qu,&nbsp;Zhenlei Xiao,&nbsp;Yangchao Luo","doi":"10.1016/j.carpta.2025.100779","DOIUrl":"10.1016/j.carpta.2025.100779","url":null,"abstract":"<div><div>This study presents a green, one-step approach for the in situ synthesis of zinc oxide (ZnO) particles within a sodium caseinate (NaCas) and carboxymethyl cellulose (CMC) matrix, with functionality enhanced by thymol essential oil. Acting as a natural reducing agent, thymol facilitated ZnO synthesis within the NaCas-CMC matrix. The film prepared with 300 mg zinc nitrate and 100 mg thymol essential oil had a low swelling rate due to in situ ZnO formation, which regulated the microstructure and enhanced hydrophobicity. The ZnO-infused NaCas-CMC biocomposite films exhibited enhanced UV shielding and water resistance, attributed to the uniform dispersion of ZnO particles and their synergistic interaction with thymol. Antibacterial assays demonstrated strong inhibitory effects against key foodborne pathogens, including<em>Listeria monocytogenes</em> (<em>L. monocytogenes</em>) and <em>Escherichia coli</em> K-12 (<em>E. coli</em> K-12). When applied to cheddar cheese, the films significantly suppressed microbial growth and effectively prevented external contamination, maintaining product safety over 20 days of refrigerated storage. Overall, this research highlights the potential of a green synthesis approach to develop multifunctional packaging films that enhance food safety while supporting sustainable practices, offering a promising alternative to conventional food packaging materials. Notably, this is the first report to describe the in situ synthesis of ZnO within a self-assembled caseinate film containing thymol essential oil, employing a surfactant-free and environmentally friendly processing method.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100779"},"PeriodicalIF":6.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile and content of fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) compounds in wheat and rye wholegrain foods
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-24 DOI: 10.1016/j.carpta.2025.100772
Aleksandra M. Torbica , Uroš Miljić , Olja Todorić , Miona Belović , Tamara Erceg , Milorad Miljić , Miloš Radosavljević
{"title":"Profile and content of fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) compounds in wheat and rye wholegrain foods","authors":"Aleksandra M. Torbica ,&nbsp;Uroš Miljić ,&nbsp;Olja Todorić ,&nbsp;Miona Belović ,&nbsp;Tamara Erceg ,&nbsp;Milorad Miljić ,&nbsp;Miloš Radosavljević","doi":"10.1016/j.carpta.2025.100772","DOIUrl":"10.1016/j.carpta.2025.100772","url":null,"abstract":"<div><div>This study aimed to provide insight into the content and profile of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) found in various types of wheat and rye wholegrain products available on the market. As dietary fiber is recommended to be consumed at a minimum of 25 g per day for its beneficial health effects, wholegrain products are an important and affordable source of this staple nutrient. However, FODMAPs can have contrasting effects on the metabolism of healthy individuals and those suffering from gastrointestinal disorders, particularly irritable bowel syndrome. This has increased the multidisciplinary research into FODMAPs over the last two decades.</div><div>In 92 samples of cereal-based foods, the total fructan content was measured using a commercially enzymatic kit. The exsess of fructose, melibiose, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and sugar polyols were determined using HPAEC-PAD method.All the analyzed pasta samples, and 88.24 % of the bread samples can be characterized as high-FODMAP products, while cookies (26.67 %) and crackers (0.00 %) were predominantly low-FODMAP products. Observing the results of all analyzed samples it can be concluded that the variations of FODMAPs content could be due to grain type, variety, climate conditions, agricultural measures, grain processing techniques (mostly milling), and type of obtained flour, as well as type of fermentation and thermal processing in the food production (shaped by the dietary habits of different cultures and regions). It was also concluded that the content of total fructo-oligosaccharides instead of total fructans should be used for the definition of the FOS content. Furthermore, the GOS content was shown to contribute significantly to the total FODMAP content.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100772"},"PeriodicalIF":6.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellulose-based interdigitated electrodes for rivaroxaban apta-sensing in blood plasma
IF 6.2
Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-24 DOI: 10.1016/j.carpta.2025.100778
Rokhsareh Ebrahimi , Mohammad Hasanzadeh , Azadeh Nilghaz , Nasrin Shadjou
{"title":"Cellulose-based interdigitated electrodes for rivaroxaban apta-sensing in blood plasma","authors":"Rokhsareh Ebrahimi ,&nbsp;Mohammad Hasanzadeh ,&nbsp;Azadeh Nilghaz ,&nbsp;Nasrin Shadjou","doi":"10.1016/j.carpta.2025.100778","DOIUrl":"10.1016/j.carpta.2025.100778","url":null,"abstract":"<div><div>Monitoring of Rivaroxaban (RIV) at trace levels in patients at risk of atrial fibrillation disorders (AFD) is of great importance. In this study, for the first time, a miniaturized interdigitated electrode (mIDE) biosensor was fabricated using superconducting silver nano ink for the detection of RIV in human plasma. The biosensor exhibited a linear detection range of 10–1000 nM with a lower limit of quantification of 10 nM. The specificity of the biosensor was also validated through square wave voltammetry in the presence of potential interfering compounds, confirming its selectivity and reliability. Based on obtained results, integration of biosensor technology and flexible electronics enhance the mIDE performance, making it a promising tool for real-time monitoring of RIV levels in clinical settings, especially for atrial fibrillation. This low-cost device shows great potential for the pharmaceutical analysis.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100778"},"PeriodicalIF":6.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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