Carbohydrate Polymer Technologies and Applications最新文献_第2页

Formulation and statistical optimization of Salvia hispanica L. Seed Polysaccharide/ chitosan nanoparticles for targeted delivery of quercetin in osteosarcoma 鼠尾草种子多糖/壳聚糖纳米颗粒靶向递送槲皮素骨肉瘤的配方及统计优化

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-11-29 DOI: 10.1016/j.carpta.2025.101059

Sara Hasan , Nazrul Islam , Derek Richard , Tony Wang , Emad. L. Izake

{"title":"Formulation and statistical optimization of Salvia hispanica L. Seed Polysaccharide/ chitosan nanoparticles for targeted delivery of quercetin in osteosarcoma","authors":"Sara Hasan , Nazrul Islam , Derek Richard , Tony Wang , Emad. L. Izake","doi":"10.1016/j.carpta.2025.101059","DOIUrl":"10.1016/j.carpta.2025.101059","url":null,"abstract":"<div><div>Achieving controlled drug release within the tumour microenvironment remains a major barrier to effective chemotherapy. The present study demonstrates the development of a low-cost, biodegradable nanocarrier that responds selectively to acidic tumour conditions, providing a safer alternative to current delivery systems. The hybrid nanoparticles were developed by the self-assembly of chitosan and <em>Salvia hispanica</em> L. seed polysaccharide, which combines the biocompatibility of natural polymers with intrinsic pH sensitivity. A bioactive flavonoid, quercetin, was successfully encapsulated within chitosan and <em>Salvia hispanica</em> L. seed polysaccharide nanoparticles with an efficiency of 78.8 %. The fabricated nanoparticles had a size of 212 nm, an optimal size for passive tumour accumulation through the enhanced permeation and retention effect. A pH-responsive behaviour was observed, with significantly higher release calculated at pH 5.5 (acidic tumor microenvironment) compared to physiological pH 7.4. The kinetic modelling of release profile identified anomalous diffusion as the dominant mechanism under acidic conditions, while fickian diffusion was observed at physiological pH. The cell inhibition potential of quercetin loaded nanoparticles was assessed in U2OS osteosarcoma model. The cell viability assay confirmed that quercetin loaded nanoparticles retained potent metabolic inhibition, indicative of preserved bioactivity of quercetin post-encapsulation.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101059"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compatibilization strategies and mechanical performances of starch-based blends for sustainable packaging 可持续包装中淀粉基共混物的增容策略和机械性能

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.carpta.2025.101051

Sangwoo Kwon , Gunhee Park , Hyunho Jang , Su-il Park

{"title":"Compatibilization strategies and mechanical performances of starch-based blends for sustainable packaging","authors":"Sangwoo Kwon , Gunhee Park , Hyunho Jang , Su-il Park","doi":"10.1016/j.carpta.2025.101051","DOIUrl":"10.1016/j.carpta.2025.101051","url":null,"abstract":"<div><div>Starch-based biodegradable polymer blends are promising candidates for sustainable packaging, pairing renewability and biodegradability with reducing environmental burdens. However, thermoplastic starch is hindered by inherent hydrophilicity, limited mechanical strength, and high moisture sensitivity. Moreover, the intrinsic incompatibility between starch and biodegradable polymers such as poly(lactic acid) and poly(butylene adipate-co-terephthalate) leads to poor interfacial adhesion, phase separation, and reduced mechanical integrity. Addressing this interfacial disparity is therefore essential to achieving performance levels suitable for large-scale packaging applications. This review systematically evaluates recent advances in compatibilization strategies for starch-based biodegradable polymer blends, which are categorized into three major classes, namely, physical, reactive, and hybrid nanofiller-assisted approaches. Each strategy is analyzed in terms of its interfacial mechanisms and their effects on morphological evolution and overall mechanical performance. Emerging green compatibilization pathways, including deep eutectic solvent (DES)-assisted and bio-derived systems, are also assessed for their potential to reconcile environmental sustainability with industrial scalability. Reactive and hybrid methods generally provide superior interfacial stability and mechanical reinforcement, though challenges persist regarding processing control, scalability, and biodegradability preservation. Collectively, these insights establish a framework for designing high-performance starch-based blends that integrate structural functionality with sustainable processing, accelerating their transition from laboratory-scale concepts to practical, low-carbon packaging solutions.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101051"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring mechanical and functional properties of 3D-printed nanocellulose-alginate scaffolds via alternative ionic crosslinkers 通过替代离子交联剂定制3d打印纳米纤维素-海藻酸盐支架的机械和功能特性

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.carpta.2026.101084

Ana Peharda , Florian Lackner , Tobias Steindorfer , Julia Fink , Petra Kotzbeck , Rupert Kargl , Karin Stana Kleinscheck , Tamilselvan Mohan

{"title":"Tailoring mechanical and functional properties of 3D-printed nanocellulose-alginate scaffolds via alternative ionic crosslinkers","authors":"Ana Peharda , Florian Lackner , Tobias Steindorfer , Julia Fink , Petra Kotzbeck , Rupert Kargl , Karin Stana Kleinscheck , Tamilselvan Mohan","doi":"10.1016/j.carpta.2026.101084","DOIUrl":"10.1016/j.carpta.2026.101084","url":null,"abstract":"<div><div>Renewable polysaccharides combined with advanced 3D printing enable precise, biomimetic scaffolds for tissue engineering (TE). Alginate hydrogels offer excellent biocompatibility and rapid gelation but lack mechanical strength and bioactivity. Adding nanofibrillated cellulose (NFC) improves rheological and structural properties, yet research has mostly focused on conventional calcium-based crosslinking. This study evaluates insoluble divalent metal carbonate crosslinkers (Mg²⁺, Ca²⁺, Zn²⁺, Sr²⁺) in NFC–alginate inks printed via direct-ink-writing (DIW) 3D printing. Rheological tests confirmed shear-thinning behavior dominated by the polymer matrix, facilitating extrusion printing. Improved dimensional and mechanical stability resulted from gradual metal ion release and in situ crosslinking triggered by acetic acid in an ethanol–water medium. Sr²⁺-crosslinked scaffolds achieved the highest tensile strength (3.5 MPa) and modulus (16%), outperforming Ca²⁺, Mg²⁺, and Zn²⁺. Sr²⁺ and Ca²⁺ also showed superior ion retention (>75%) and dimensional stability. SEM/EDX analysis confirmed compact matrices with uniform ion distribution. Cytocompatibility assays revealed that Sr²⁺ and Ca²⁺ scaffolds maintained high human cell viability (>80%), while Zn²⁺ was cytotoxic (<30%). These results highlight Sr²⁺ carbonate crosslinking as optimal for mechanical performance and biocompatibility, advancing NFC–alginate bioinks for regenerative and functional biomaterial applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101084"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning the biological scaffolds’ performance by the combination of two antioxidant and antimicrobial chitosan derivatives 两种抗氧化和抗菌壳聚糖衍生物的组合调节生物支架的性能

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.carpta.2025.101069

C. Muñoz-Núñez , A. Barco-Martín , K. Deshpande , D.S. Schmidt , L. González-García , S. Trujillo , A. Muñoz-Bonilla , M. Fernández-García

{"title":"Tuning the biological scaffolds’ performance by the combination of two antioxidant and antimicrobial chitosan derivatives","authors":"C. Muñoz-Núñez , A. Barco-Martín , K. Deshpande , D.S. Schmidt , L. González-García , S. Trujillo , A. Muñoz-Bonilla , M. Fernández-García","doi":"10.1016/j.carpta.2025.101069","DOIUrl":"10.1016/j.carpta.2025.101069","url":null,"abstract":"<div><div>In this study novel polymeric materials based on chitosan (CS) were synthesized by chemically modifying CS with two bioactive moieties: eugenol and a compound containing a thiazolium group. These modifications aimed to impart antioxidant and antimicrobial properties to the matrix. Additionally, the scaffolds were reinforced with chitin nanowhiskers (Nw) to improve their mechanical strength and stability. Porous three-dimensional scaffolds were fabricated via the freeze-drying process, resulting in highly interconnected pore networks suitable for cell infiltration and nutrient transport. Biological characterization revealed that the incorporation of the two bioactive groups significantly enhanced the antioxidant activity and antimicrobial efficacy against both Gram-positive and Gram-negative bacteria to the scaffolds. Mechanical testing demonstrated that the Nw reinforcement increased scaffold stiffness and resilience without compromising porosity. In vitro biological assays using fibroblasts showed favorable cytocompatibility and promoted sustained cell proliferation over three weeks. Fluorescence microscopy confirmed fibroblast adhesion and morphological adaptation within the scaffold architecture. Additionally, the scaffolds were evaluated for their immunomodulatory effects using macrophage cultures, revealing a balanced immune response with reduced proinflammatory signaling, which is critical for successful integration and reduced fibrosis in vivo. These results indicate that those are promising candidates for tissue engineering and regenerative medicine applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101069"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerated chitin nanofiber-stabilized Pickering emulsions: Structure, rheology, and stability evaluation 再生几丁质纳米纤维稳定皮克林乳剂：结构、流变性和稳定性评价

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.carpta.2026.101097

Mingyang Fang , Xiaoxue Yin , RuLan Qi , Xuedong Wang , Wenping Ding , Beibei Ding

{"title":"Regenerated chitin nanofiber-stabilized Pickering emulsions: Structure, rheology, and stability evaluation","authors":"Mingyang Fang , Xiaoxue Yin , RuLan Qi , Xuedong Wang , Wenping Ding , Beibei Ding","doi":"10.1016/j.carpta.2026.101097","DOIUrl":"10.1016/j.carpta.2026.101097","url":null,"abstract":"<div><div>Developing sustainable and high-performance biobased stabilizers is essential for advancing Pickering emulsion technology. Chitin nanofibers, characterized by their unique structural properties, amphiphilic nature, and biocompatibility, have emerged as promising candidates for use as Pickering particles. However, current production methods are energy-intensive, costly, and environmentally harmful, thereby restricting their application in Pickering emulsions. This study developed regenerated chitin nanofibers (<em>Re</em>-ChNFs) using an alkali-urea dissolution-regeneration method and explored their structure and emulsion-stabilizing mechanisms. The <em>Re</em>-ChNFs showed superior wettability and a favorable surface charge under near-neutral conditions, which facilitated their adsorption at the oil-water interface. Moreover, they were observed to form dense interfacial layers and fibrillar networks, leading to reduced droplet sizes and improved rheological properties. This research underscores the advantages of dissolution-regeneration chitin nanofibers and provides valuable insights into their interfacial interactions, proposing a promising strategy for the development of biodegradable Pickering stabilizers.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101097"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of the structures, interactions, and mechanical properties of methacrylate-modified gellan gum 甲基丙烯酸酯改性结冷胶的结构、相互作用和力学性能的分子机制

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-11-27 DOI: 10.1016/j.carpta.2025.101057

Wei-Yuan Chiu , Wan-Ting Lee , Jiashing Yu , Chia-Ching Chou

{"title":"Molecular mechanisms of the structures, interactions, and mechanical properties of methacrylate-modified gellan gum","authors":"Wei-Yuan Chiu , Wan-Ting Lee , Jiashing Yu , Chia-Ching Chou","doi":"10.1016/j.carpta.2025.101057","DOIUrl":"10.1016/j.carpta.2025.101057","url":null,"abstract":"<div><div>Gellan gum is a highly biocompatible and mechanically tunable material for tissue engineering applications. Upon modification with N-succinimidyl methacrylate, gellan gum forms a photocrosslinkable hydrogel. Specifically, increasing concentration and the degree of methacrylate substitution strengthen both the mechanical properties and biological characteristics. In this study, we employed molecular dynamics simulations to investigate how concentrations and degrees of methacrylate substitution affect the molecular structure, interactions, and mechanical properties of methacrylate-modified gellan gum. Both unmodified and methacrylate-modified gellan gum chains adopted relatively extended conformations. However, higher concentrations favored denser, entangled structures. Increasing the methacrylate substitution from 16.7 % to 33.3 % promoted steric effects that reduced chain folding, yielding more extended conformations, and thus enhanced the mechanical property. At 50 % methacrylate substitution, the strong methacrylate interactions and increased crosslink density led to recoiled conformations, reduced load-transfer efficiency, and decreased mechanical performance. Hydrogen bonding analysis revealed that higher substitution increased intramolecular hydrogen bonding but reduced intermolecular interactions, especially at higher concentrations. These findings highlight the balance between molecular conformation, crosslinking density, and hydrogen bonding in determining the mechanical behavior of gellan gum. The results provide a molecular-level design mechanism for tuning methacrylate substitution to achieve desired properties in biomedical hydrogels for bioengineering applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101057"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p-Sulfonated calix[4]arene grafted on magnetic chitosan as efficient and recyclable multifunctional bio-nanocatalyst for various organic transformations 磁性壳聚糖接枝对磺酸杯芳烃作为多种有机转化的高效、可回收多功能生物纳米催化剂

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.carpta.2025.101074

Saied Shafiei Navid, Rahman Hosseinzadeh, Mohammad Salehi

{"title":"p-Sulfonated calix[4]arene grafted on magnetic chitosan as efficient and recyclable multifunctional bio-nanocatalyst for various organic transformations","authors":"Saied Shafiei Navid, Rahman Hosseinzadeh, Mohammad Salehi","doi":"10.1016/j.carpta.2025.101074","DOIUrl":"10.1016/j.carpta.2025.101074","url":null,"abstract":"<div><div>Biopolymers are abundant and sustainable materials that have various benefits, including reducing the development of secondary pollution because of their inherent environmental friendliness. For this reason, this study aims to prepare a chitosan-based magnetic nanocatalyst by grafting sulfonated calix[4]arene as a Brønsted acid moiety onto magnetic chitosan using isophorone diisocyanate as a linker. The prepared bio-based nanocatalyst, designated as SCA@MCS, was characterized using various analysis methods, including FT-IR, PXRD, TGA, SEM, EDS/MAPP, TEM, CHNS, VSM, and Zeta potential. The simultaneous presence of chitosan and <em>p</em>-sulfonated calix[4]arene endows SCA@MCS with both acidic and basic active sites, making it an effective multifunctional nanocatalyst. Consequently, the bio-based SCA@MCS was applied as a reusable heterogenous nanocatalyst for the efficient synthesis of various organic compounds, including dihydropyridine (89–98 %), dihydropyrimidine (82–98 %), dihydropyrrolone (89–95 %), and benzoate ester derivatives (98–99 %). The absence of toxic solvents, mild reaction conditions, simple work-up procedures, the use of a low amount of nanocatalyst, high reaction yields, and the reusability of the nanocatalyst are the key advantages of the introduced SCA@MCS magnetic nanocatalyst. These results demonstrate that the grafting of sulfonated calix[4]arene onto magnetic chitosan provides an efficient bio-based multifunctional nanocatalyst for the synthesis of various biologically active compounds and biodiesel production.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101074"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of nanocellulose composite materials: Manufacturing, properties, applications, current challenges and future outlooks 综述了纳米纤维素复合材料的制备、性能、应用、当前挑战和未来展望

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.carpta.2026.101093

Awoke Fenta Wodag , Aklilu Azanaw

{"title":"A review of nanocellulose composite materials: Manufacturing, properties, applications, current challenges and future outlooks","authors":"Awoke Fenta Wodag , Aklilu Azanaw","doi":"10.1016/j.carpta.2026.101093","DOIUrl":"10.1016/j.carpta.2026.101093","url":null,"abstract":"<div><div>This review research has focused on the state-of-the-art in nanocellulose composites, such as their inherent properties, various application areas, fabrication techniques, and ongoing challenges, along with future outlooks. The current research integrates its diverse sources and isolation methods, such as cellulose nanofibers, cellulose nanocrystals, and bacterial nanocellulose, and provides a detailed discussion of composite fabrication processes and surface functionalization strategies, unlike previous documented findings, which have focused mainly on specific nanocellulose types with their single application domains. Furthermore, it highlights the connection between the structural properties of nanocellulose and composite performance in a variety of applications, ranging from packaging and biomedical to sustainable building materials in a novel way. It has also assessed its present current challenges, such as the dispersion of nanocellulose in polymer matrices, the scalability of isolation procedures and issues with the functional composites' durability. Besides, by offering a thorough and integrative viewpoint that links fundamental nanocellulose science with next-generation composite material technologies, the review sets itself apart. It does this by combining recent developments and identifying knowledge gaps to propose possible innovative strategies for enhancing the sustainability and effectiveness of nanocellulose composite materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101093"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in Konjac Glucomannan-based self-healing hydrogels for effective wound management 魔芋葡甘露聚糖自愈水凝胶的研究进展

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.carpta.2026.101106

Aaushi Pareek , Arpita Sahu , Pooja Malani , Anil Chuturgoon , Ashutosh Pareek

{"title":"Recent advances in Konjac Glucomannan-based self-healing hydrogels for effective wound management","authors":"Aaushi Pareek , Arpita Sahu , Pooja Malani , Anil Chuturgoon , Ashutosh Pareek","doi":"10.1016/j.carpta.2026.101106","DOIUrl":"10.1016/j.carpta.2026.101106","url":null,"abstract":"<div><div>The skin has an intrinsic capacity for regeneration and serves as a critical barrier against microbial invasion, mechanical damage, and environmental stress; this function is compromised in acute and chronic wounds, necessitating effective strategies for rapid repair. Hydrogel‑based dressings have gained prominence because they can absorb exudates, maintain a moist microenvironment, and support tissue regeneration. Konjac glucomannan (KGM), a biocompatible and biodegradable polysaccharide, has been increasingly explored as a matrix for advanced wound dressings due to its hydrophilicity and chemically tunable hydroxyl-rich backbone. Recent studies have reported KGM-based self-healing hydrogels constructed through reversible non-covalent interactions (for example, hydrogen bonding and metal coordination) and dynamic covalent linkages (including Schiff base and acylhydrazone bonds). These dynamic networks enable fast recovery after mechanical disruption, improving durability, injectability, and conformability on irregular or mechanically stressed wound sites. In parallel, KGM-based composite hydrogels integrating nanoparticles, exosomes, and antimicrobial agents have been developed to improve infection, oxidative stress, and impaired angiogenesis in complex wound microenvironments. This review summarises recent advances in the design, fabrication and biological performance of KGM-based self-healing hydrogels across acute and chronic wound models, and highlights key material-design challenges and translational considerations that should guide future technology development and clinical translation.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101106"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly tunable chitosan and carboxymethylated dextran hydrogels crosslinked with NHS/EDC with potential application for preventing postoperative adhesions 高度可调的壳聚糖和羧甲基化右旋糖酐水凝胶与NHS/EDC交联，具有预防术后粘连的潜在应用

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.carpta.2026.101101

Vaiana Moreau , Benoît Liberelle , Faranak Baniahmad , Nick Virgilio , Gregory De Crescenzo

{"title":"Highly tunable chitosan and carboxymethylated dextran hydrogels crosslinked with NHS/EDC with potential application for preventing postoperative adhesions","authors":"Vaiana Moreau , Benoît Liberelle , Faranak Baniahmad , Nick Virgilio , Gregory De Crescenzo","doi":"10.1016/j.carpta.2026.101101","DOIUrl":"10.1016/j.carpta.2026.101101","url":null,"abstract":"<div><div>Postoperative adhesions (POA) are a complication arising after surgery, causing pain and inflammation. Their treatment leads to significant costs, a considerable financial strain on both patients and healthcare systems. To address this issue, we have developed fully biocompatible hydrogels composed of chitosan (CHI) and carboxymethylated dextran (CMD), chemically crosslinked with carbodiimide chemistry (i.e. NHS/EDC) and producing no undesired side-reactions, as a potential surgical aid and physical barrier against POA. Of interest, CHI is used without any chemical modification, since the addition of sodium bicarbonate to the formulation promotes both its solubilisation at nearly neutral or slightly alkaline pH, and inhibits CHI uncontrolled complexation and precipitation with CMD, yielding uniform and transparent hydrogels. We tested a wide range of CHI:CMD mixtures for their gelling kinetics. Those were shown to be tuned with temperature, ranging from approx. 1 min at 37 °C, to over 30 min at 4 °C - making these hydrogels injectable and/or moldable. Ultimately, we showed that the crosslinking chemistry using NHS/EDC can be used with pristine CHI and any biopolymer containing carboxylic groups, making this approach accessible, well-defined and highly versatile for the preparation of hydrogels destined to the prevention of POA, and for biomedical applications in general.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101101"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0