Carbohydrate Polymer Technologies and Applications最新文献_第2页

In-situ anchoring an Ag-based metal-organic framework onto carboxymethylcellulose hydrogel film: A potential bio-platform for antibiotic-free wound dressing 在羧甲基纤维素水凝胶膜上原位锚定银基金属有机框架：无抗生素伤口敷料的潜在生物平台

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-15 DOI: 10.1016/j.carpta.2025.100943

Amin Hashemi Aghdam, Siamak Javanbakht, Reza Mohammadi

{"title":"In-situ anchoring an Ag-based metal-organic framework onto carboxymethylcellulose hydrogel film: A potential bio-platform for antibiotic-free wound dressing","authors":"Amin Hashemi Aghdam, Siamak Javanbakht, Reza Mohammadi","doi":"10.1016/j.carpta.2025.100943","DOIUrl":"10.1016/j.carpta.2025.100943","url":null,"abstract":"<div><div>An efficient method for preventing bacterial infections of wounds is to prepare an antibacterial agent with the right mechanical, antibiotic, and water vapor permeability features. In this work, a novel method was applied to develop a nanocomposite bio-platform by in-situ anchoring of silver-based metal-organic frameworks (Ag-MOFs) onto the carboxymethylcellulose (CMC) hydrogel film. In this regard, CMC films were prepared using citric acid and glycerol as a crosslinker and plasticizer, respectively. Subsequently, Ag-MOFs were synthesized directly on the film surface via immersion-coordination of Ag⁺ ions with 2-aminoterephthalic acid, eliminating the need for additional stabilizers. Various techniques (i.e., FT-IR, XRD, SEM, EDX-mapping, AFM, etc.) were utilized that verify the successful synthesis of CMC/Ag-MOF nanocomposite. The results of in-vitro cytotoxicity and antibacterial assays demonstrated that the CMC/Ag-MOF nanocomposite exhibited acceptable cytocompatibility, maintaining cell viability above 60 % at a concentration of 8 mg/mL against human skin fibroblast cells (HFF-2). Moreover, it showed significantly enhanced antibacterial performance, with inhibition zones against <em>S. aureus</em> and <em>Escherichia coli</em> increasing by approximately 66.7 % and 87.5 %, respectively, compared to the pure CMC film. The obtained results recommended CMC/Ag-MOF hydrogel films as a potential antimicrobial dressing.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100943"},"PeriodicalIF":6.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction and characterization of cellulose and cellulose nanocrystals from the stalks of Marrubium vulgare plant 从凡夫兰茎中提取纤维素及纤维素纳米晶的研究

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-15 DOI: 10.1016/j.carpta.2025.100947

Muhammad Naveed Khan , Aftab Ahmad , Noor Rehman , Seda Kelestemur , Muhammad Tariq , Abdul Khaliq Jan , Shujaat Ahmad , Dorthe M. Eisele , Wajid Syed , Mahmood Basil A Al-Rawi

{"title":"Extraction and characterization of cellulose and cellulose nanocrystals from the stalks of Marrubium vulgare plant","authors":"Muhammad Naveed Khan , Aftab Ahmad , Noor Rehman , Seda Kelestemur , Muhammad Tariq , Abdul Khaliq Jan , Shujaat Ahmad , Dorthe M. Eisele , Wajid Syed , Mahmood Basil A Al-Rawi","doi":"10.1016/j.carpta.2025.100947","DOIUrl":"10.1016/j.carpta.2025.100947","url":null,"abstract":"<div><div>In this study, we report on how cellulose and nanocellulose can be extracted and prepared, respectively, from the <em>Marrubium vulgare</em> plant by employing environmentally friendly multistep chemical procedures. These multistep procedures include soxhlet extraction, alkaline treatment, and entirely chlorine-free bleaching methods. Specifically, soxhlet extraction is employed for the removal of pectin, cutin, waxes and other extractives, while alkaline treatment is employed to eliminate hemicellulose and lignin and, finally, bleaching methods are utilized for the delignification of the cellulosic biomaterial. Fourier transform infrared (FTIR) provided evidence on successful elimination of hemicellulose, lignin, and other non-cellulosic material. X-ray Diffraction (XRD) analysis revealed crystallinity of the extracted cellulosic material; hence the Segal method was utilized to determine the level of crystallinity of 63.58±5 %. Additionally, the Scherrer equation was employed to determine the thickness of the crystals of about 32.5 ± 10 Å. Thermogravimetric analysis (TGA) revealed the cellulosic materials’ thermal degradation behavior. Lastly, the acid hydrolysis of cellulosic material with sulfuric acid led to the formation of nanocellulose as characterized via transmission electron microscopy (TEM). It was observed that the extracted nanocellulose exhibited an average length of 409.3 ± 0.42 nm and width of 55.7 ± 0.36 nm with an average aspect ratio of 7.34 ± 0.05.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100947"},"PeriodicalIF":6.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Static and dynamic behavior of loose sand and silty sand treated with guar and agar gums (Micro and macro study) 瓜尔胶和琼脂胶处理松散砂和粉砂的静态和动态特性（微观和宏观研究）

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-13 DOI: 10.1016/j.carpta.2025.100944

Parviz Maleki , Mehdi Gharib , Saman Soleimani Kutanaei , Hossein Ghasemnejad , Nima Ranjbar Malidarreh

{"title":"Static and dynamic behavior of loose sand and silty sand treated with guar and agar gums (Micro and macro study)","authors":"Parviz Maleki , Mehdi Gharib , Saman Soleimani Kutanaei , Hossein Ghasemnejad , Nima Ranjbar Malidarreh","doi":"10.1016/j.carpta.2025.100944","DOIUrl":"10.1016/j.carpta.2025.100944","url":null,"abstract":"<div><div>This study evaluates the impact of guar gum and agar gum on the enhancement of mechanical, shear, and liquefaction resistance properties of loose sand and silty sand. Various tests, including indirect tensile strength (ITS), unconfined compressive strength (UCS), unconsolidated undrained triaxial (UU), direct shear test (DST), ultrasonic pulse velocity (UPV), scanning electron microscopy (SEM) and consolidated undrained cyclic triaxial (CCU), were conducted on sand soil and silty sand treated with various contents (0.5 %, 1 %, and 2 % by dry weight of soil) of agar gum and guar gum. The results showed a significant increase in strength with biopolymer stabilization. The UCS of untreated soils showed negligible resistance (UCS≈0 kPa), while treated with 2 % agar and guar gum, the UCS reached 2322 and 1911 kPa in sandy soil, and 3189 and 2522 kPa in silty sand, respectively. In contrast, increasing the biopolymer content led to a decrease in the drained internal friction angle. The liquefaction resistance of sand and silty sand was substantially improved with agar gum stabilization. At a cyclic stress ratio (CSR) of 0.2, stabilization with 2 % agar gum increased the number of cycles to liquefaction (NL) in sandy soil by 440 %.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100944"},"PeriodicalIF":6.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun PVA/alginate/cellulose nanofibers for probiotic delivery: Fabrication, stability, and in vitro viability of probiotics 用于益生菌输送的静电纺丝PVA/海藻酸盐/纤维素纳米纤维：制备、稳定性和益生菌的体外生存能力

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-11 DOI: 10.1016/j.carpta.2025.100938

Asad Nawaz , Sana Irshad , Xiaofang Luo , Zuodong Qin , Noman Walayat , Mohammad Rizwan Khan , Rizwan Tahir , Noor Akram , Gholamreza Abdi

{"title":"Electrospun PVA/alginate/cellulose nanofibers for probiotic delivery: Fabrication, stability, and in vitro viability of probiotics","authors":"Asad Nawaz , Sana Irshad , Xiaofang Luo , Zuodong Qin , Noman Walayat , Mohammad Rizwan Khan , Rizwan Tahir , Noor Akram , Gholamreza Abdi","doi":"10.1016/j.carpta.2025.100938","DOIUrl":"10.1016/j.carpta.2025.100938","url":null,"abstract":"<div><div>In this research, PVA/SA/CL based nanosheets were fabricated to encapsulate <em>Lactobacillus rhamnosus</em> GG (ATCC 53,103) using different ratios of PVA (polyvinyl alcohol), sodium alginate (SA) and carboxymethyl cellulose (CL), prepared nanosheets were characterized by encapsulation efficiency (EE %), mechanical properties, microstructure, molecular characterizations, thermal stability and <em>in vitro</em> viability under simulated conditions. Results show that PVA/SA/CL composites have potential as polymers for probiotic encapsulation, with an EE of 82.06 %. The zeta potential showed the small particle size recorded as - 11.49 ± 0.655 (mV). The secondary structure by Fourier transform infrared (FTIR) spectra showed strong bonding between encapsulating materials and probiotics, which was evidenced by successful loading of probiotics among scanning electron microscopy (SEM). The findings of <em>in vitro</em> GI analysis publicized the significantly (<em>p</em> < 0.05) improved survival of encapsulated probiotics from 11.01 to 5.32 and 13.84 to 8.69 (Log CFU/ml) at pH 2 and 7, respectively. Moreover, thermal analysis revealed that at 82 °C, probiotics were effectively protected with 94 % of nanosheet weight retention.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100938"},"PeriodicalIF":6.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential, formulation strategies and cancer treatment applications of ripe papaya pectin (Carica papaya L.): A comprehensive review 成熟木瓜果胶的治疗潜力、配方策略及抗癌应用综述

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-11 DOI: 10.1016/j.carpta.2025.100942

Hrushikesh Wagh, Sankha Bhattacharya

{"title":"Therapeutic potential, formulation strategies and cancer treatment applications of ripe papaya pectin (Carica papaya L.): A comprehensive review","authors":"Hrushikesh Wagh, Sankha Bhattacharya","doi":"10.1016/j.carpta.2025.100942","DOIUrl":"10.1016/j.carpta.2025.100942","url":null,"abstract":"<div><div>This review presents a critical appraisal of ripe papaya pectin <em>(Carica papaya L.)</em> (RPP) as a multifaceted biopolymer for cancer treatment, highlighting its structural complexity, bioactivity, and pharmaceutical potential. RPP, with its high molecular weight polysaccharide composition of galacturonic acid and homogalacturonan rhamnogalacturonan domains, possesses significant antitumor activity through galectin-3 inhibition, activation of caspase-3, and immunomodulatory release of cytokines. The review examines cutting-edge extraction techniques, i.e., microwave-assisted extraction (MAE), enzymatic hydrolysis, and solvent systems and how they extensively influence the molecular weight distribution (20–150 kDa), methylation level, and bioavailability. This review recognizes major formulation challenges to the clinical usefulness of ripe papaya pectin (RPP), specifically to delivering pH-responsive, target-specific drug release with low systemic toxicity. RPP-derived nanocarriers micelles, hydrogels, and liposomes exhibit improved cellular uptake, sustained release, and physicochemical stability. Methods such as FTIR, HPLC, and NMR reveal structural properties associated with therapeutic performance. Preclinical experiments validate RPP's selective cytotoxicity against tumour cells with minimal effect on healthy tissue. This paper suggests that RPP, optimally tailored through biofunctionalization and refined delivery design, spans nutraceutical potential and oncological use, and presents robust translational capacity as a low-toxicity, biocompatible foundation in future cancer therapeutics.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100942"},"PeriodicalIF":6.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen 人类精液中高度聚焦的n -聚糖的结构和位点特异性表征

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-09 DOI: 10.1016/j.carpta.2025.100941

Miaomiao Xin , Yintai Xu , Shanshan You , Cheng Li , Jiechen Shen , Bojing Zhu , Qiaohong Zhao , Juanzi Shi , Shisheng Sun

{"title":"Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen","authors":"Miaomiao Xin , Yintai Xu , Shanshan You , Cheng Li , Jiechen Shen , Bojing Zhu , Qiaohong Zhao , Juanzi Shi , Shisheng Sun","doi":"10.1016/j.carpta.2025.100941","DOIUrl":"10.1016/j.carpta.2025.100941","url":null,"abstract":"<div><div>Heavy fucosylation (fucose residues ≥ 6 per glycan) has been previously reported in human semen with unclear precise site-specific glycan structures. In current study, we characterized heavily fucosylated glycoproteins as a distinctive feature of human spermatozoa (HS) and seminal plasma (HSP), with a precise definition of glycan structural features at the glycosite-specific level. There were 49 unique heavily fucosylated intact glycopeptides (IGPs) at 15 <em>N-</em>glycosites from 12 glycoproteins identified in HS, and 188 unique heavily fucosylated IGPs at 58 <em>N-</em>glycosites from 37 glycoproteins in HSP. Among these heavily fucosylated glycoproteins, 10 were shared in HS and HSP, 2 were detected only in HS and 17 only in HSP. Almost all heavily fucosylated glycans were complex <em>N-</em>glycans with core fucosylation and Lewis antennary, among which CLU were glycosylated by ten and nine fucoses per glycan in HS and HSP, respectively. Moreover, these heavily fucosylated glycans varied from tri- to hexa-antennas. Notably, the <em>N-</em>glycan structures on shared heavily fucosylated glycoproteins were more complex in HSP than in HS. These heavily fucosylated glycoproteins identified in human semen represent a valuable and distinctive resource for glycopeptide studies, offering significant potential for advancing glycoproteomic methodologies and clinical research into male infertility.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100941"},"PeriodicalIF":6.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of tartaric acid and castor oil on the characteristics of low-density polyethylene/thermoplastic starch composite films 酒石酸和蓖麻油对低密度聚乙烯/热塑性淀粉复合薄膜性能的影响

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-08 DOI: 10.1016/j.carpta.2025.100898

Narges Jannatiha , Nasser Sedaghat , Seyed Mohammad Ali Razavi

{"title":"Effect of tartaric acid and castor oil on the characteristics of low-density polyethylene/thermoplastic starch composite films","authors":"Narges Jannatiha , Nasser Sedaghat , Seyed Mohammad Ali Razavi","doi":"10.1016/j.carpta.2025.100898","DOIUrl":"10.1016/j.carpta.2025.100898","url":null,"abstract":"<div><div>Low-density polyethylene (LDPE) and thermoplastic starch (TPS) films containing varying concentrations of tartaric acid (0, 1.5, and 3 %) and castor oil (0, 1, and 2 %) were produced using an extrusion process. Field-emission scanning electron microscopy images confirmed a smooth and homogeneous surface with the combination of tartaric acid (TA) and castor oil (CO), indicating good compatibility between the polymer components. The formation of starch ester bonds with TA and CO was observed in the Fourier transform infrared spectroscopy spectrum. Dynamic mechanical thermal analysis results demonstrated that the addition of TA and CO to the LDPE/TPS films resulted in a decrease in the glass transition temperature and a positive change in the storage modulus. The sample with the highest biodegradability percentage was LDPE/TPS/TA3 %/CO1 %, which achieved a biodegradability rate of 34.46 %. This was attributed to acid hydrolysis and a reduction in the polymer's molecular weight over a six-month period of storage in soil. The water solubility, contact angle, and water vapor permeability of the sample LDPE/TPS/TA3 %/CO1 % were measured at 9 %, 88.35°, and 3.51 × 10<sup>–6</sup> gs<sup>-1</sup>m<sup>-1</sup>Pa<sup>-1</sup> respectively. The mechanical properties of the composite films improved with the addition of TA and CO due to the cross-linking effect; specifically, the tensile strength, elongation at break, and heat seal strength of LDPE/TPS/TA3 %/CO1 % were 9.77 MPa, 8.48 %, and 8.45 MPa, respectively. The highest opacity value was recorded for the sample LDPE/TPS/TA3 %/CO2 %, which measured 12.55, surpassing the other samples. The melt flow index of the sample LDPE/TPS/TA3 %/CO1 % was determined to be 6.27 g/10 min, while the sample LDPE/TPS/TA3 % had a melt flow index of 9.70 g/10 min. The addition of TA and CO also enhanced the oxygen barrier properties of the films.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100898"},"PeriodicalIF":6.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization and anti-inflammatory activity of a polysaccharide extracted from the root of Tripterygium wilfordii 雷公藤根提取多糖的结构表征及抗炎活性

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-08 DOI: 10.1016/j.carpta.2025.100939

Yonghong Miao , Yunhui Zhang , Xiaoyue Zhang , Chunling Li , Xin Liu , Jinchu Yang , Yi Zheng , Na Li , Jiaqi Wang , Zichao Wang , Lemei An

{"title":"Structural characterization and anti-inflammatory activity of a polysaccharide extracted from the root of Tripterygium wilfordii","authors":"Yonghong Miao , Yunhui Zhang , Xiaoyue Zhang , Chunling Li , Xin Liu , Jinchu Yang , Yi Zheng , Na Li , Jiaqi Wang , Zichao Wang , Lemei An","doi":"10.1016/j.carpta.2025.100939","DOIUrl":"10.1016/j.carpta.2025.100939","url":null,"abstract":"<div><div><em>Tripterygium wilfordii</em>, a traditional Chinese medicine, is widely utilized in the treatment of rheumatoid arthritis; however, the anti-inflammatory activity and potential applications of its polysaccharides have been less explored. In the present study, a water-soluble polysaccharide, designated TWP, was extracted from the roots of <em>T. wilfordii</em>, and its structural features and anti-inflammatory activity were investigated. The yield of TWP was 3.91 % ± 0.24 %, with carbohydrate and protein contents of 90.77 % ± 2.06 % and 2.67 % ± 0.81 %, respectively. Monosaccharide analysis revealed that TWP comprised rhamnose, arabinose, galactose, glucose, xylose, mannose, and glucuronic acid in a molar ratio of 16.0967: 8.3376: 27.925: 16.378: 0.5017: 0.4017: 6.4507. The weight-averaged (Mw) and number-averaged (Mn) molecular weights of TWP were 6713.24 kDa and 3188.86 kDa, respectively, with a polydispersity index (PDI) of 2.105. In vitro antioxidant assays demonstrated that TWP could scavenge hydroxyl, superoxide, DPPH, and ABTS radicals. Furthermore, TWP significantly reduced the levels of inflammation-related factors (NO, TNF-α, IL-6, and IL-1β) and the expression of their corresponding genes in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in a concentration-dependent manner. Additionally, TWP markedly enhanced the activities of SOD, CAT, and GSH-Px, while reducing MDA level in LPS-induced RAW 264.7 macrophages.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100939"},"PeriodicalIF":6.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing Aureobasidium pullulans β-Glucan water solubility by carboxymethylation modification and its characterization study 羧甲基化修饰提高普鲁兰毛霉β-葡聚糖水溶性及其表征研究

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-08 DOI: 10.1016/j.carpta.2025.100940

Wenchao Li, Mengzhen Wang, Tao Xu, Yanchun Zhang, Cheng Zhong

引用次数: 0

Sugar nanocluster adhesive boosts wound healing in diabetic mice 糖纳米团簇粘合剂促进糖尿病小鼠伤口愈合

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-07-08 DOI: 10.1016/j.carpta.2025.100933

Asila Osman , Young Hoon Song , Muneeb Ullah , Yeongjun Kim , Heetak Lee , Jin-Wook Yoo , Dong Soo Hwang , Jeong Hyun Seo

{"title":"Sugar nanocluster adhesive boosts wound healing in diabetic mice","authors":"Asila Osman , Young Hoon Song , Muneeb Ullah , Yeongjun Kim , Heetak Lee , Jin-Wook Yoo , Dong Soo Hwang , Jeong Hyun Seo","doi":"10.1016/j.carpta.2025.100933","DOIUrl":"10.1016/j.carpta.2025.100933","url":null,"abstract":"<div><div>In this study, we developed levan-catechol iron oxide (LC-IO) nanoclusters as multifunctional bioadhesive agents with strong tissue adhesion, antibacterial activity, and regenerative potential. The nanoclusters were fabricated via electrospray, yielding uniform, stable particles with catechol-mediated surface functionalization. Antibacterial evaluation using <em>Escherichia coli</em> (BL21) transformed with pTH-GFPuv showed a prolonged bacterial lag phase and reduced growth, indicating effective microbial suppression.</div><div>LC-IO nanoclusters demonstrated strong adhesive performance even at low concentrations (5 mg/mL), with lap shear stress and adhesion energy values of 30.13 kPa and 0.74 kJ/ m<sup>3</sup>, respectively more than double those of commercial fibrin glue (13.47 kPa and 0.33 kJ/m<sup>3</sup>).</div><div>Transcriptomic analysis of treated human dermal fibroblasts showed upregulation of genes related to extracellular matrix remodeling, angiogenesis, and cell migration. <em>In vivo</em> wound healing studies demonstrated that after 7 days, LC-IO–treated wounds achieved 86 % closure compared to 60 % in untreated controls. In a diabetic mouse model, 92 % of the wound area was healed by day 14 <em>versus</em> 62 % in untreated wounds.</div><div>These findings support LC-IO nanoclusters as a promising platform for wound healing applications, integrating strong adhesion, antimicrobial efficacy, and regenerative stimulation. Their ability to accelerate healing, particularly in diabetic wounds, highlights their potential for advanced wound care.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100933"},"PeriodicalIF":6.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0