Carbohydrate Polymer Technologies and Applications最新文献_第9页

Unlocking the potential of cellulose-based composite materials for supercapacitors and sensing technologies: A Review 释放纤维素基复合材料在超级电容器和传感技术中的潜力：综述

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-27 DOI: 10.1016/j.carpta.2025.100926

Tekalign Aregu Tikish , Abera Demeke Ambaye , Touhami Mokrani , Eno E. Ebenso

{"title":"Unlocking the potential of cellulose-based composite materials for supercapacitors and sensing technologies: A Review","authors":"Tekalign Aregu Tikish , Abera Demeke Ambaye , Touhami Mokrani , Eno E. Ebenso","doi":"10.1016/j.carpta.2025.100926","DOIUrl":"10.1016/j.carpta.2025.100926","url":null,"abstract":"<div><div>Cellulose aerogels exhibit a specific surface area (10–975 m² <em>g</em><sup>−1</sup>), porosity (84.0–99.9 %), and density (0.0005–0.35 g cm-³) comparable to synthetic polymer aerogels, but uniquely offer higher compressive strength (5.2 kPa–16.67 MPa) alongside superior biodegradability. Cellulose-based aerogels have experienced significant growth in research interest over the past decade. Publications in this field have dramatically increased from 19 in 2010 to over 385 in 2024, highlighting their unique physicochemical characteristics. Renowned for their porous structure, low thermal conductivity, low density, and exceptional adsorption capabilities for water and organic solvents, cellulose aerogels hold substantial promise for high-performance materials. This review, therefore, aims to illustrate three key aerogel processing routes: dispersion, regeneration, and cellulose derivative methods, alongside five prominent modification techniques for aerogel composites. Furthermore, it briefly discusses the application of cellulose aerogels as a core component in supercapacitors (electrodes, separators, and electrolytes), showcasing examples like fluorine-treated CNF achieving 409 F g⁻¹ specific capacitance with 91 % retention after 10,000 cycles. The review also examines the utilization of these aerogels in electrochemical, pressure, piezoelectric, humidity, and environmental sensors, concluding with a discussion of their potential future implications and applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100926"},"PeriodicalIF":6.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhalation toxicity of cellulose nanofibrils: A review of key findings and future directions 纤维素纳米原纤维的吸入毒性：主要发现和未来发展方向的综述

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-27 DOI: 10.1016/j.carpta.2025.100913

Katsuhide Fujita, Akihiro Moriyama

{"title":"Inhalation toxicity of cellulose nanofibrils: A review of key findings and future directions","authors":"Katsuhide Fujita, Akihiro Moriyama","doi":"10.1016/j.carpta.2025.100913","DOIUrl":"10.1016/j.carpta.2025.100913","url":null,"abstract":"<div><div>Cellulose nanofibrils (CNFs) have attracted increasing research attention as sustainable and biodegradable nanomaterials with applications across diverse industrial sectors, including packaging, agriculture, and biomedical engineering. However, owing to their ultrafine size and fibrous morphology, concerns have emerged regarding their potential inhalation toxicity and long-term health effects. This review examines recent studies addressing CNF-induced lung inflammation, pulmonary distribution, retention, clearance, phagocytosis by alveolar macrophages, and <em>in vitro</em> cytotoxicity. Key findings indicate that short-term exposure to CNFs generally induces mild pulmonary inflammation, which is less severe compared to that caused by other fibrous nanomaterials such as carbon nanotubes (CNTs). The fiber length and diameter of CNFs significantly influence their pulmonary distribution and the severity of inflammatory responses. CNFs exhibit prolonged retention in the lung tissue and are phagocytosed by alveolar macrophages, although no significant cytotoxicity has been observed <em>in vitro</em>. Biological impurities, including bacterial endotoxins, are often present in CNF suspensions and may influence toxicity outcomes; however, their exact contributions remain unclear. Due to variations in source materials and processing methods, CNFs require case-by-case inhalation toxicity assessment. This review also highlights the need for standardized characterization, advanced exposure models, and appropriate safety and regulatory measures for their responsible use.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100913"},"PeriodicalIF":6.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers -环糊精在感染性疾病治疗中的作用：其功能超越了简单的药物载体

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-27 DOI: 10.1016/j.carpta.2025.100921

Amine Pochet , Priscille Brodin , Ruxandra Gref , Arnaud Machelart

{"title":"Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers","authors":"Amine Pochet , Priscille Brodin , Ruxandra Gref , Arnaud Machelart","doi":"10.1016/j.carpta.2025.100921","DOIUrl":"10.1016/j.carpta.2025.100921","url":null,"abstract":"<div><div>Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dCDs) have attracted significant interest due to their remarkable versatility and distinctive physicochemical properties. Among them, beta-cyclodextrins (βCDs) and their derivatives (dβCDs) have emerged as particularly promising tools in the fight against infectious diseases, not only as drug delivery systems but also as active agents that modulate host-pathogen interactions. Recent studies have revealed their ability to modulate immune responses, disrupt microbial membranes, and interfere with quorum sensing, thereby limiting biofilm formation and related antimicrobial resistance. Therefore, in this review, we focus on the intrinsic properties of β-cyclodextrins and their derivatives in the context of infectious diseases. βCD-based compounds possess inherent biological activities that are increasingly being exploited for therapeutic purposes, including host-directed therapies, antimicrobial action, biofilm disruption, and vaccine development.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100921"},"PeriodicalIF":6.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of poly(ethylene glycol)-based cross-linker length on the physicochemical and rheological properties of hyaluronic acid hydrogels potentially applicable in the biomedical field 聚乙二醇基交联剂长度对生物医学领域潜在应用透明质酸水凝胶理化和流变性能的影响

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-27 DOI: 10.1016/j.carpta.2025.100908

Fabiana Cordella , Giuseppe Alonci , Gaetano Angelici , Roberto Mocchi , Martina Savona , Giulia Grimaldi , Giulia Galasso , Sabrina Sommatis , Celia Duce , Elena Pulidori , Elisa Martinelli , Nicola Zerbinati

{"title":"Effect of poly(ethylene glycol)-based cross-linker length on the physicochemical and rheological properties of hyaluronic acid hydrogels potentially applicable in the biomedical field","authors":"Fabiana Cordella , Giuseppe Alonci , Gaetano Angelici , Roberto Mocchi , Martina Savona , Giulia Grimaldi , Giulia Galasso , Sabrina Sommatis , Celia Duce , Elena Pulidori , Elisa Martinelli , Nicola Zerbinati","doi":"10.1016/j.carpta.2025.100908","DOIUrl":"10.1016/j.carpta.2025.100908","url":null,"abstract":"<div><div>The development of safe and effective hyaluronic acid-based materials is one of the main research focuses for biomedical applications. However, so far, an investigation of the influence of the cross-linker chain length on the physicochemical, mechanical, and rheological properties of the material has never been reported. Therefore, in the present work, a polydisperse poly(ethylene glycol) diglycidyl ether (PEGDE) and six monodisperse PEGDE with a well-defined length were successfully synthesized by a simple method and used as cross-linkers of hyaluronic acid to obtain hydrogels which differed only for the length of the cross-linker. Our results indicate that the cross-linking density, determined by using Flory-Rehner equation, and the total content of the cross-linker in the formulation, determined by <sup>1</sup>H NMR, decrease with PEGDE length. However, the formulations with the longer polydisperse PEGDEs (<em>n</em> ≥ 6) exhibits a higher storage modulus (<em>G</em>' = 110.4–114.7 Pa) and a stiffer mechanical behaviour, indicating that cross-linker chain length influences significantly the rheological properties of hydrogels.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100908"},"PeriodicalIF":6.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of ethyl cellulose-coated urea for high-performance controlled release 乙基纤维素包被尿素高效控释工艺优化

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-26 DOI: 10.1016/j.carpta.2025.100920

Yuanfang Zhou, Han Li, Sen Zhao, Sihui Yan, Juan Li , Xiangdong Yang

{"title":"Optimization of ethyl cellulose-coated urea for high-performance controlled release","authors":"Yuanfang Zhou, Han Li, Sen Zhao, Sihui Yan, Juan Li , Xiangdong Yang","doi":"10.1016/j.carpta.2025.100920","DOIUrl":"10.1016/j.carpta.2025.100920","url":null,"abstract":"<div><div>The development of controlled-release urea (CRU) using ethyl cellulose (EC) represents a significant strategy for advancing the green and sustainable development of agriculture. However, limited research on EC-coated urea preparation was reported before. This study employed EC/ethanol to develop CRU through fluidized bed technology and investigated the effects of the coating processes, material plasticization modification and surface treatment on the film structure and nitrogen release properties of CRU. The results demonstrated that the fluidizing gas temperature significantly influenced both the film structure and release performance. When the coating temperature was 50 °C, a continuous and uniform dense film was formed, resulting in optimal controlled-release performance lasting up to 7 days. Additionally, the effects of the peristaltic pump rate and coating liquid concentration were minimal. The plasticization effect of DBS was validated through XRD analysis, which demonstrated a reduction in the crystallinity of the EC, an enhanced fracture elongation of the film, and an extended controlled-release performance to 10 days. Furthermore, surface treatment with 1 % and 2 % paraffin wax improved the water barrier properties of the film, increasing its water contact angle from 100° to 130°. Consequently, the controlled-release period of the coated urea was extended to 50 days, meeting the ISO 18644:2016 standard. This study is valuable for fertilizer production and provides a reference for cellulose-coated fertilizers.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100920"},"PeriodicalIF":6.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel carbohydrate-based nanomedicine: A pH-responsive cyclodextrin/Zein/TiO₂ nanoemulsion for sustained release and enhanced anti-cancer effects of quercetin 新型碳水化合物纳米药物：一种ph响应的环糊精/玉米蛋白/ tio2纳米乳，用于槲皮素的缓释和增强抗癌作用

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-26 DOI: 10.1016/j.carpta.2025.100874

Mansour Bahadori , Mehrab Pourmadadi , Majid Abdouss , Seyed Hassan Jafari

{"title":"Novel carbohydrate-based nanomedicine: A pH-responsive cyclodextrin/Zein/TiO₂ nanoemulsion for sustained release and enhanced anti-cancer effects of quercetin","authors":"Mansour Bahadori , Mehrab Pourmadadi , Majid Abdouss , Seyed Hassan Jafari","doi":"10.1016/j.carpta.2025.100874","DOIUrl":"10.1016/j.carpta.2025.100874","url":null,"abstract":"<div><div>Nanocarriers derived from carbohydrate polymers offer a promising approach to overcoming the limitations of conventional cancer therapies, particularly by enhancing tumor targeting and enabling sustained drug release. A novel nanoemulsion based on Cyclodextrin, Zein, and TiO<sub>2</sub> nanoparticles was developed and loaded with Quercetin as the therapeutic agent to address these challenges. The interactions among the nanoemulsion components were characterized using FTIR spectroscopy, while XRD provided insights into their crystallinity. The nanoemulsion exhibited a spherical morphology with a size range between 80–120 nm, confirmed by SEM and DLS. Zeta potential results indicated higher stability in blood circulation with around -50 mV surface charge. High loading and encapsulation efficiency showed the impact of TiO<sub>2</sub> in nanoemulsion by improving LE % and EE % to 47.5 % and 87.75 %, respectively. The in vitro release results in different pH circumstances (7.4 and 5.4) indicated controlled, pH-sensitive release behavior over 96 h. The experimental data fitted into various release kinetic models and determined the best release mechanisms. The MTT assay demonstrated the nanocarrier's selective toxicity on A549 and L929 cell lines, as cancerous and normal cells, respectively. The results indicate the biocompatibility of Quercetin-loaded nanoemulsion and its positive effect on higher A549 cellular inhibition by a controlled higher release rate of Quercetin in the target site. These results suggest that the developed nanocarrier holds promise for addressing the challenges associated with conventional lung cancer treatments through controlled and targeted drug delivery.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100874"},"PeriodicalIF":6.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steamed root of Rehmannia glutinosa Libosch. relieves methotrexate-induced intestinal mucositis in mice with manninotriose as a core mediator 地黄蒸根。以甘露糖为核心介质缓解甲氨蝶呤诱导的小鼠肠黏膜炎

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-25 DOI: 10.1016/j.carpta.2025.100919

Ling Wei , Yujing Sun , Yujiao Li , Cory J. Xian , Xue-Sen Wen

{"title":"Steamed root of Rehmannia glutinosa Libosch. relieves methotrexate-induced intestinal mucositis in mice with manninotriose as a core mediator","authors":"Ling Wei , Yujing Sun , Yujiao Li , Cory J. Xian , Xue-Sen Wen","doi":"10.1016/j.carpta.2025.100919","DOIUrl":"10.1016/j.carpta.2025.100919","url":null,"abstract":"<div><div>Chemotherapy-induced intestinal mucositis is a serious complication with few effective treatment options. In Traditional Chinese Medicine (TCM), this toxicity is attributed to Qi and Yin deficiencies, and the steamed root of <em>Rehmannia glutinosa</em> Libosch. (SRR) is commonly prescribed for its therapeutic benefits. This study aimed to evaluate SRR’s effects on methotrexate (MTX)-induced mucositis by modulating the gut microbiota. Mice were administered MTX (300 mg/kg) and SRR (1.56 g/kg), and gut microbiota changes were analysed by 16S rRNA sequencing. Network pharmacology was employed to identify SRR’s active components. SRR alleviated MTX-induced fatigue, diarrhea, weight loss, and intestinal villous damage, and modulated gut microbiota by reducing <em>Clostridium</em> levels, adjusting the <em>Firmicutes/Bacteroidetes</em> ratio, and promoting Gram-positive bacteria. SRR also reduced oxidative damage and inflammation markers (MDA, iNOS and NF-κB) without affecting MTX blood levels. Manninotriose was identified as one of the key active constituents. In conclusion, SRR alleviates MTX-induced intestinal mucositis by exerting antioxidative, anti-inflammatory, and gut microbiota-modulating effects.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100919"},"PeriodicalIF":6.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of self-healing process and strength of biopolymer-stabilized silty sand: Comparison of Xanthan and Persian gum in geotechnical engineering 生物聚合物稳定粉砂自愈过程及强度的研究：黄原胶与波斯胶在岩土工程中的比较

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-25 DOI: 10.1016/j.carpta.2025.100914

Farhad Askari , Mehdi Gharib , Nima Ranjbar Malidarreh , Mojtaba Esmaeilnia Amiri , Saman Soleimani Kutanaei

{"title":"Investigation of self-healing process and strength of biopolymer-stabilized silty sand: Comparison of Xanthan and Persian gum in geotechnical engineering","authors":"Farhad Askari , Mehdi Gharib , Nima Ranjbar Malidarreh , Mojtaba Esmaeilnia Amiri , Saman Soleimani Kutanaei","doi":"10.1016/j.carpta.2025.100914","DOIUrl":"10.1016/j.carpta.2025.100914","url":null,"abstract":"<div><div>This study investigates the self-healing behavior and strength development of silty sand stabilized with two natural biopolymers: Persian gum (PG), a plant-based biopolymer with a relatively linear structure, and Xanthan gum (XG), a microbially derived biopolymer with a branched molecular structure. The biopolymers were used at contents of 0.5 %, 1 %, and 2 % by dry weight of soil. Cylindrical samples were cured under different conditions and then intentionally damaged to evaluate healing after 7, 28, and 90 days. Mechanical performance was assessed using unconfined compressive strength (UCS) and ultrasonic pulse velocity (UPV), and microstructural changes were examined via SEM and AFM. Results showed that the highest strength gains occurred with 2 % biopolymer content after 28 days of curing. UCS reached 950 kPa for PG and 1193.6 kPa for XG. XG-stabilized samples showed greater healing capacity (38 % UCS recovery after 90 days) but also higher strength loss over time. PG, while offering slightly lower strength, provided more stable performance and lower sensitivity to moisture-induced damage. A strong correlation (R² = 0.9561) was observed between UCS and UPV, confirming UPV as a reliable non-destructive method for assessing self-healing. Overall, PG is proposed as a sustainable and effective alternative for long-term stabilization of silty sands.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100914"},"PeriodicalIF":6.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of chitosan thin barrier layers on the oxygen permeability and optical properties of poly(lactic acid) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) multilayers 壳聚糖薄阻隔层对聚乳酸和聚3-羟基丁酸-co-3-羟基戊酸多层膜透氧性和光学性能的影响

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-25 DOI: 10.1016/j.carpta.2025.100918

I. Bernabé Vírseda , M.U. de la Orden , J. Martínez Urreaga

{"title":"Effects of chitosan thin barrier layers on the oxygen permeability and optical properties of poly(lactic acid) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) multilayers","authors":"I. Bernabé Vírseda , M.U. de la Orden , J. Martínez Urreaga","doi":"10.1016/j.carpta.2025.100918","DOIUrl":"10.1016/j.carpta.2025.100918","url":null,"abstract":"<div><div>Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(lactic acid) (PLA) are highly promising biobased and biodegradable polymers in food packaging industry due to their mechanical and optical properties, and improved sustainability. Nevertheless, some properties like O<sub>2</sub> permeability need improvement. In this work we have prepared and tested bilayers from PLA and blends of PLA and PHBV, with an additional thin layer of chitosan (CH) to reduce the oxygen transmission rate (OTR) without compromising optical properties. In these materials, the poor compatibility between hydrophilic CH and hydrophobic biopolymers is a serious handicap, as it leads to weak adhesion between the layers. The hydrophobic polymer surfaces were activated with aqueous NaOH at room temperature for different times, which increased hydrophilic character. Considering that biopolyesters can undergo NaOH-catalised hydrolytic degradation, the effect of NaOH treatment on the structure of the polymers was also studied by using FT-IR spectroscopy, scanning electron microscopy (FE-SEM), microhardness and contact angle measurements. Both the use of PHBV and a thin layer of CH lead to significant decreases in O<sub>2</sub> permeability. The decrease is greater in the case of the inner CH layer, which also reduces UV transmittance without significantly affecting the transparency of the film.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100918"},"PeriodicalIF":6.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocellulose polymorphs for biomedical applications: Recent advances, prospects and challenges - A review 纳米纤维素多晶型物在生物医学上的应用：最新进展、前景和挑战综述

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-24 DOI: 10.1016/j.carpta.2025.100916

S.M Israk Arman Rafee , MD Sami-Ul Alim , Shafqat Alam , Khandoker Samaher Salem

{"title":"Nanocellulose polymorphs for biomedical applications: Recent advances, prospects and challenges - A review","authors":"S.M Israk Arman Rafee , MD Sami-Ul Alim , Shafqat Alam , Khandoker Samaher Salem","doi":"10.1016/j.carpta.2025.100916","DOIUrl":"10.1016/j.carpta.2025.100916","url":null,"abstract":"<div><div>In the modern era, biodegradable and eco-friendly products are crucial for ensuring a sustainable future. Nanocellulose, derived from cellulose, is widely adopted for modern applications due to its versatility, sustainability, and biodegradability. Nanocellulose polymorphs, such as Cellulose Nanocrystals (CNC), Cellulose Nanofibrils (CNF), and Bacterial Nanocellulose (BNC), have found successful utilization in biomedicine due to their high strength and rigidity (CNC), toughness and flexibility (CNF), and superior biocompatibility and water retention (BNC); all while being lightweight, sustainable, and outperforming synthetic polymers, metals, and traditional cellulose in specialized applications. Nanocellulose excels in biomedicine due to its anisotropic strength, customizable porosity, and biocompatibility, which presents challenges, such as balancing surface functionalization with immunogenicity, optimizing enzymatic biodegradation kinetics, and navigating ISO-compliant manufacturing protocols for clinical-grade reproducibility. This paper encompasses literature published from 2006 to 2025, focusing on the applications of nanocellulose in the medical sector, including drug delivery systems, tissue engineering, wound healing, biosensors, medical implants, and dialysis membranes. This review also highlights the challenges of commercializing and utilizing nanocellulose in clinical settings. Some key issues include scaling up production processes, ensuring reproducibility, meeting regulatory and safety standards, assessing its environmental impact, potential cytotoxicity, and the lack of standardized protocols for characterization and testing.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100916"},"PeriodicalIF":6.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0