Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application

IF 6.5 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-06-23 DOI:10.1016/j.carpta.2025.100906

Mahmoud Abbaszadeh , Nasser Arsalani , Fahimeh Kazeminava , Amin Mahoutforoush

{"title":"Incorporating halloysite nanotubes@malva extract into Starch-Hyaluronic acid nanocomposite films containing carbon quantum dots for antibacterial application","authors":"Mahmoud Abbaszadeh , Nasser Arsalani , Fahimeh Kazeminava , Amin Mahoutforoush","doi":"10.1016/j.carpta.2025.100906","DOIUrl":null,"url":null,"abstract":"<div><div>Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed >90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100906"},"PeriodicalIF":6.5000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymer Technologies and Applications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666893925002476","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Antibacterial polymer-based nanocomposite films have garnered increasing attention for their applications in wound dressing and tissue engineering. In this study, starch-hyaluronic acid (S-HA) nanocomposite films reinforced with halloysite nanotubes loaded with Malva extract (HNTs@M) and carbon quantum dots (CQDs) were prepared. The inclusion of HNTs improved tensile strength (up to 266.86 MPa for 100 mg HNTs), reduced swelling, and enabled controlled Malva extract release (about 60 for 48 h). CQDs acted as softeners and crosslinkers, enhancing flexibility. The films exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli (inhibition zones of 0.4 ± 0.1 cm and 0.3 ± 0.1 cm, respectively). Cytotoxicity assays showed >90 % HFFF cell viability after 24 and 48 h, revealing a good cytocompatibility of S-HA/HNTs@M/CQDs. These results suggest that the developed S-HA/HNTs@M/CQDs nanocomposite films are promising candidates for multifunctional wound dressings.

查看原文本刊更多论文

将高岭土nanotubes@malva萃取物加入含有碳量子点的淀粉-透明质酸纳米复合膜中用于抗菌

抗菌聚合物基纳米复合膜在伤口敷料和组织工程方面的应用越来越受到人们的关注。在这项研究中，制备了淀粉-透明质酸（S-HA）纳米复合膜，该膜由高岭土纳米管负载Malva提取物（HNTs@M）和碳量子点（CQDs）增强。加入HNTs可提高抗拉强度（100 mg HNTs可达266.86 MPa），减少肿胀，并可控制Malva提取物的释放（约60个48小时）。cqd作为柔软剂和交联剂，增强了柔韧性。该膜对金黄色葡萄球菌和大肠杆菌具有明显的抑菌活性（抑制区分别为0.4±0.1 cm和0.3±0.1 cm）。细胞毒性实验显示，24和48 h后HFFF细胞存活率为90%，表明S-HA/HNTs@M/CQDs具有良好的细胞相容性。这些结果表明，制备的S-HA/HNTs@M/CQDs纳米复合膜是多功能伤口敷料的理想候选材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Carbohydrate Polymer Technologies and Applications

CiteScore

8.70

自引率

0.00%

发文量