Carbohydrate Polymer Technologies and Applications最新文献_第4页

Fabricating a chitosan-based human placenta extract–encapsulated elastic zonal-structured scaffold for osteochondral applications 基于壳聚糖的人胎盘提取物包封弹性带状结构骨软骨支架的制备

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.carpta.2025.101064

Hossein Shaygani , Mohammad Shahverdi , Mohamadreza Soltani , Mohammad Rezaei , Sona Zare , Amir Shamloo , Kaivan Mohammadi

{"title":"Fabricating a chitosan-based human placenta extract–encapsulated elastic zonal-structured scaffold for osteochondral applications","authors":"Hossein Shaygani , Mohammad Shahverdi , Mohamadreza Soltani , Mohammad Rezaei , Sona Zare , Amir Shamloo , Kaivan Mohammadi","doi":"10.1016/j.carpta.2025.101064","DOIUrl":"10.1016/j.carpta.2025.101064","url":null,"abstract":"<div><div>Articular cartilage is an avascular and multilayer tissue with limited self-regenerating properties. 3D printing offers a promising approach for fabricating intricate structures that closely replicate the architecture and functional properties of native cartilage. In this study, we fabricated a four-layer 3D-printed thermoplastic polyurethane (TPU) scaffold with varying porosities, ranging from the lowest porosity at the bottom to the highest at the top, to mimic the mechanical properties of cartilage layers from the deep zone to the transition zone. An injectable hydrogel consisting of chitosan (CS) and human placenta extract (HPE) was injected into the 3D-printed scaffold to provide a growth factor-loaded, extracellular matrix (ECM)-mimicking environment with suitable cytocompatibility, aiming to enhance the low cellular activity of the TPU scaffold. An electrospun layer was used as the superficial layer of the scaffold to replicate the longitudinal orientation of collagen fibers at the cartilage surface. Mechanical analysis demonstrated zonal strain distribution in the scaffold similar to native cartilage tissue. The antibacterial assay demonstrated the bactericidal effects of CS and HPE, showing an inhibition zone of (2.892 ± 0.103 mm). The MTT assay quantitatively evaluated the cellular functionality of scaffolds, demonstrating sustained cell viability over 7 days. These combined features make this scaffold design an exceptional candidate for cartilage tissue regeneration applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101064"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compatibilization strategies and mechanical performances of starch-based blends for sustainable packaging 可持续包装中淀粉基共混物的增容策略和机械性能

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.carpta.2025.101051

Sangwoo Kwon , Gunhee Park , Hyunho Jang , Su-il Park

{"title":"Compatibilization strategies and mechanical performances of starch-based blends for sustainable packaging","authors":"Sangwoo Kwon , Gunhee Park , Hyunho Jang , Su-il Park","doi":"10.1016/j.carpta.2025.101051","DOIUrl":"10.1016/j.carpta.2025.101051","url":null,"abstract":"<div><div>Starch-based biodegradable polymer blends are promising candidates for sustainable packaging, pairing renewability and biodegradability with reducing environmental burdens. However, thermoplastic starch is hindered by inherent hydrophilicity, limited mechanical strength, and high moisture sensitivity. Moreover, the intrinsic incompatibility between starch and biodegradable polymers such as poly(lactic acid) and poly(butylene adipate-co-terephthalate) leads to poor interfacial adhesion, phase separation, and reduced mechanical integrity. Addressing this interfacial disparity is therefore essential to achieving performance levels suitable for large-scale packaging applications. This review systematically evaluates recent advances in compatibilization strategies for starch-based biodegradable polymer blends, which are categorized into three major classes, namely, physical, reactive, and hybrid nanofiller-assisted approaches. Each strategy is analyzed in terms of its interfacial mechanisms and their effects on morphological evolution and overall mechanical performance. Emerging green compatibilization pathways, including deep eutectic solvent (DES)-assisted and bio-derived systems, are also assessed for their potential to reconcile environmental sustainability with industrial scalability. Reactive and hybrid methods generally provide superior interfacial stability and mechanical reinforcement, though challenges persist regarding processing control, scalability, and biodegradability preservation. Collectively, these insights establish a framework for designing high-performance starch-based blends that integrate structural functionality with sustainable processing, accelerating their transition from laboratory-scale concepts to practical, low-carbon packaging solutions.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101051"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring mechanical and functional properties of 3D-printed nanocellulose-alginate scaffolds via alternative ionic crosslinkers 通过替代离子交联剂定制3d打印纳米纤维素-海藻酸盐支架的机械和功能特性

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.carpta.2026.101084

Ana Peharda , Florian Lackner , Tobias Steindorfer , Julia Fink , Petra Kotzbeck , Rupert Kargl , Karin Stana Kleinscheck , Tamilselvan Mohan

{"title":"Tailoring mechanical and functional properties of 3D-printed nanocellulose-alginate scaffolds via alternative ionic crosslinkers","authors":"Ana Peharda , Florian Lackner , Tobias Steindorfer , Julia Fink , Petra Kotzbeck , Rupert Kargl , Karin Stana Kleinscheck , Tamilselvan Mohan","doi":"10.1016/j.carpta.2026.101084","DOIUrl":"10.1016/j.carpta.2026.101084","url":null,"abstract":"<div><div>Renewable polysaccharides combined with advanced 3D printing enable precise, biomimetic scaffolds for tissue engineering (TE). Alginate hydrogels offer excellent biocompatibility and rapid gelation but lack mechanical strength and bioactivity. Adding nanofibrillated cellulose (NFC) improves rheological and structural properties, yet research has mostly focused on conventional calcium-based crosslinking. This study evaluates insoluble divalent metal carbonate crosslinkers (Mg²⁺, Ca²⁺, Zn²⁺, Sr²⁺) in NFC–alginate inks printed via direct-ink-writing (DIW) 3D printing. Rheological tests confirmed shear-thinning behavior dominated by the polymer matrix, facilitating extrusion printing. Improved dimensional and mechanical stability resulted from gradual metal ion release and in situ crosslinking triggered by acetic acid in an ethanol–water medium. Sr²⁺-crosslinked scaffolds achieved the highest tensile strength (3.5 MPa) and modulus (16%), outperforming Ca²⁺, Mg²⁺, and Zn²⁺. Sr²⁺ and Ca²⁺ also showed superior ion retention (>75%) and dimensional stability. SEM/EDX analysis confirmed compact matrices with uniform ion distribution. Cytocompatibility assays revealed that Sr²⁺ and Ca²⁺ scaffolds maintained high human cell viability (>80%), while Zn²⁺ was cytotoxic (<30%). These results highlight Sr²⁺ carbonate crosslinking as optimal for mechanical performance and biocompatibility, advancing NFC–alginate bioinks for regenerative and functional biomaterial applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101084"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning the biological scaffolds’ performance by the combination of two antioxidant and antimicrobial chitosan derivatives 两种抗氧化和抗菌壳聚糖衍生物的组合调节生物支架的性能

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.carpta.2025.101069

C. Muñoz-Núñez , A. Barco-Martín , K. Deshpande , D.S. Schmidt , L. González-García , S. Trujillo , A. Muñoz-Bonilla , M. Fernández-García

{"title":"Tuning the biological scaffolds’ performance by the combination of two antioxidant and antimicrobial chitosan derivatives","authors":"C. Muñoz-Núñez , A. Barco-Martín , K. Deshpande , D.S. Schmidt , L. González-García , S. Trujillo , A. Muñoz-Bonilla , M. Fernández-García","doi":"10.1016/j.carpta.2025.101069","DOIUrl":"10.1016/j.carpta.2025.101069","url":null,"abstract":"<div><div>In this study novel polymeric materials based on chitosan (CS) were synthesized by chemically modifying CS with two bioactive moieties: eugenol and a compound containing a thiazolium group. These modifications aimed to impart antioxidant and antimicrobial properties to the matrix. Additionally, the scaffolds were reinforced with chitin nanowhiskers (Nw) to improve their mechanical strength and stability. Porous three-dimensional scaffolds were fabricated via the freeze-drying process, resulting in highly interconnected pore networks suitable for cell infiltration and nutrient transport. Biological characterization revealed that the incorporation of the two bioactive groups significantly enhanced the antioxidant activity and antimicrobial efficacy against both Gram-positive and Gram-negative bacteria to the scaffolds. Mechanical testing demonstrated that the Nw reinforcement increased scaffold stiffness and resilience without compromising porosity. In vitro biological assays using fibroblasts showed favorable cytocompatibility and promoted sustained cell proliferation over three weeks. Fluorescence microscopy confirmed fibroblast adhesion and morphological adaptation within the scaffold architecture. Additionally, the scaffolds were evaluated for their immunomodulatory effects using macrophage cultures, revealing a balanced immune response with reduced proinflammatory signaling, which is critical for successful integration and reduced fibrosis in vivo. These results indicate that those are promising candidates for tissue engineering and regenerative medicine applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101069"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerated chitin nanofiber-stabilized Pickering emulsions: Structure, rheology, and stability evaluation 再生几丁质纳米纤维稳定皮克林乳剂：结构、流变性和稳定性评价

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.carpta.2026.101097

Mingyang Fang , Xiaoxue Yin , RuLan Qi , Xuedong Wang , Wenping Ding , Beibei Ding

{"title":"Regenerated chitin nanofiber-stabilized Pickering emulsions: Structure, rheology, and stability evaluation","authors":"Mingyang Fang , Xiaoxue Yin , RuLan Qi , Xuedong Wang , Wenping Ding , Beibei Ding","doi":"10.1016/j.carpta.2026.101097","DOIUrl":"10.1016/j.carpta.2026.101097","url":null,"abstract":"<div><div>Developing sustainable and high-performance biobased stabilizers is essential for advancing Pickering emulsion technology. Chitin nanofibers, characterized by their unique structural properties, amphiphilic nature, and biocompatibility, have emerged as promising candidates for use as Pickering particles. However, current production methods are energy-intensive, costly, and environmentally harmful, thereby restricting their application in Pickering emulsions. This study developed regenerated chitin nanofibers (<em>Re</em>-ChNFs) using an alkali-urea dissolution-regeneration method and explored their structure and emulsion-stabilizing mechanisms. The <em>Re</em>-ChNFs showed superior wettability and a favorable surface charge under near-neutral conditions, which facilitated their adsorption at the oil-water interface. Moreover, they were observed to form dense interfacial layers and fibrillar networks, leading to reduced droplet sizes and improved rheological properties. This research underscores the advantages of dissolution-regeneration chitin nanofibers and provides valuable insights into their interfacial interactions, proposing a promising strategy for the development of biodegradable Pickering stabilizers.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101097"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of the structures, interactions, and mechanical properties of methacrylate-modified gellan gum 甲基丙烯酸酯改性结冷胶的结构、相互作用和力学性能的分子机制

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-11-27 DOI: 10.1016/j.carpta.2025.101057

Wei-Yuan Chiu , Wan-Ting Lee , Jiashing Yu , Chia-Ching Chou

{"title":"Molecular mechanisms of the structures, interactions, and mechanical properties of methacrylate-modified gellan gum","authors":"Wei-Yuan Chiu , Wan-Ting Lee , Jiashing Yu , Chia-Ching Chou","doi":"10.1016/j.carpta.2025.101057","DOIUrl":"10.1016/j.carpta.2025.101057","url":null,"abstract":"<div><div>Gellan gum is a highly biocompatible and mechanically tunable material for tissue engineering applications. Upon modification with N-succinimidyl methacrylate, gellan gum forms a photocrosslinkable hydrogel. Specifically, increasing concentration and the degree of methacrylate substitution strengthen both the mechanical properties and biological characteristics. In this study, we employed molecular dynamics simulations to investigate how concentrations and degrees of methacrylate substitution affect the molecular structure, interactions, and mechanical properties of methacrylate-modified gellan gum. Both unmodified and methacrylate-modified gellan gum chains adopted relatively extended conformations. However, higher concentrations favored denser, entangled structures. Increasing the methacrylate substitution from 16.7 % to 33.3 % promoted steric effects that reduced chain folding, yielding more extended conformations, and thus enhanced the mechanical property. At 50 % methacrylate substitution, the strong methacrylate interactions and increased crosslink density led to recoiled conformations, reduced load-transfer efficiency, and decreased mechanical performance. Hydrogen bonding analysis revealed that higher substitution increased intramolecular hydrogen bonding but reduced intermolecular interactions, especially at higher concentrations. These findings highlight the balance between molecular conformation, crosslinking density, and hydrogen bonding in determining the mechanical behavior of gellan gum. The results provide a molecular-level design mechanism for tuning methacrylate substitution to achieve desired properties in biomedical hydrogels for bioengineering applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101057"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p-Sulfonated calix[4]arene grafted on magnetic chitosan as efficient and recyclable multifunctional bio-nanocatalyst for various organic transformations 磁性壳聚糖接枝对磺酸杯芳烃作为多种有机转化的高效、可回收多功能生物纳米催化剂

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.carpta.2025.101074

Saied Shafiei Navid, Rahman Hosseinzadeh, Mohammad Salehi

{"title":"p-Sulfonated calix[4]arene grafted on magnetic chitosan as efficient and recyclable multifunctional bio-nanocatalyst for various organic transformations","authors":"Saied Shafiei Navid, Rahman Hosseinzadeh, Mohammad Salehi","doi":"10.1016/j.carpta.2025.101074","DOIUrl":"10.1016/j.carpta.2025.101074","url":null,"abstract":"<div><div>Biopolymers are abundant and sustainable materials that have various benefits, including reducing the development of secondary pollution because of their inherent environmental friendliness. For this reason, this study aims to prepare a chitosan-based magnetic nanocatalyst by grafting sulfonated calix[4]arene as a Brønsted acid moiety onto magnetic chitosan using isophorone diisocyanate as a linker. The prepared bio-based nanocatalyst, designated as SCA@MCS, was characterized using various analysis methods, including FT-IR, PXRD, TGA, SEM, EDS/MAPP, TEM, CHNS, VSM, and Zeta potential. The simultaneous presence of chitosan and <em>p</em>-sulfonated calix[4]arene endows SCA@MCS with both acidic and basic active sites, making it an effective multifunctional nanocatalyst. Consequently, the bio-based SCA@MCS was applied as a reusable heterogenous nanocatalyst for the efficient synthesis of various organic compounds, including dihydropyridine (89–98 %), dihydropyrimidine (82–98 %), dihydropyrrolone (89–95 %), and benzoate ester derivatives (98–99 %). The absence of toxic solvents, mild reaction conditions, simple work-up procedures, the use of a low amount of nanocatalyst, high reaction yields, and the reusability of the nanocatalyst are the key advantages of the introduced SCA@MCS magnetic nanocatalyst. These results demonstrate that the grafting of sulfonated calix[4]arene onto magnetic chitosan provides an efficient bio-based multifunctional nanocatalyst for the synthesis of various biologically active compounds and biodiesel production.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101074"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorizing date waste into functional bacterial nanocellulose with dual adsorption–antifouling properties for wastewater remediation 将枣泥废渣转化为具有双重吸附-防污性能的功能性细菌纳米纤维素用于废水修复

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.carpta.2025.101071

Jahirul Ahmed Mazumder , Aniss Kedjour , Adiba Akram , Mussarat Tasleem , Fawzi Banat

{"title":"Valorizing date waste into functional bacterial nanocellulose with dual adsorption–antifouling properties for wastewater remediation","authors":"Jahirul Ahmed Mazumder , Aniss Kedjour , Adiba Akram , Mussarat Tasleem , Fawzi Banat","doi":"10.1016/j.carpta.2025.101071","DOIUrl":"10.1016/j.carpta.2025.101071","url":null,"abstract":"<div><div>The valorization of agro-industrial byproducts is crucial for establishing circular bioeconomies. This study presents a novel approach to produce bacterial nanocellulose (BNC) using date seeds (DS) and pomace (DP) as sustainable, low-cost carbon feedstocks for <em>Komagataeibacter hansenii and</em> examines whether feedstock chemistry alone can program the functionality of BNC. DP and DS extracts presented contrasting soluble profiles, which translated into differences in BNC yield and function. DP-BNC showed superior production and hydration (WUC = 552 ± 31 % vs 480 ± 25 % for DS-BNC) and retained the cellulose I structure. Spectroscopic studies indicated the in situ incorporation of hydrophilic motifs, and ζ-potential measurements at pH 7 revealed a negative surface charge (∼ −25.6 mV) of BNC. Furthermore, DP-BNC functioned as a highly effective biosorbent, achieving adsorption capacities of 4.62 ± 0.26 mg/g for the cationic dye Crystal Violet (CV) and 3.85 ± 0.20 mg/g for Methyl Orange (MO), with pseudo-second-order kinetics and Langmuir equilibria; capacities were retained at ∼52 % for CV and ∼48 % for MO till the fifth cycle. Antifouling assays demonstrated 41.4 % lower BSA adsorption and 93.1 % lower <em>Escherichia coli</em> colonization on DP-BNC compared to DS-BNC. This research establishes a pragmatic pathway for transforming low-value dates residues into a high-performance biomaterial.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101071"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of nanocellulose composite materials: Manufacturing, properties, applications, current challenges and future outlooks 综述了纳米纤维素复合材料的制备、性能、应用、当前挑战和未来展望

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.carpta.2026.101093

Awoke Fenta Wodag , Aklilu Azanaw

{"title":"A review of nanocellulose composite materials: Manufacturing, properties, applications, current challenges and future outlooks","authors":"Awoke Fenta Wodag , Aklilu Azanaw","doi":"10.1016/j.carpta.2026.101093","DOIUrl":"10.1016/j.carpta.2026.101093","url":null,"abstract":"<div><div>This review research has focused on the state-of-the-art in nanocellulose composites, such as their inherent properties, various application areas, fabrication techniques, and ongoing challenges, along with future outlooks. The current research integrates its diverse sources and isolation methods, such as cellulose nanofibers, cellulose nanocrystals, and bacterial nanocellulose, and provides a detailed discussion of composite fabrication processes and surface functionalization strategies, unlike previous documented findings, which have focused mainly on specific nanocellulose types with their single application domains. Furthermore, it highlights the connection between the structural properties of nanocellulose and composite performance in a variety of applications, ranging from packaging and biomedical to sustainable building materials in a novel way. It has also assessed its present current challenges, such as the dispersion of nanocellulose in polymer matrices, the scalability of isolation procedures and issues with the functional composites' durability. Besides, by offering a thorough and integrative viewpoint that links fundamental nanocellulose science with next-generation composite material technologies, the review sets itself apart. It does this by combining recent developments and identifying knowledge gaps to propose possible innovative strategies for enhancing the sustainability and effectiveness of nanocellulose composite materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101093"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in Konjac Glucomannan-based self-healing hydrogels for effective wound management 魔芋葡甘露聚糖自愈水凝胶的研究进展

IF 6.5

Carbohydrate Polymer Technologies and Applications Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.carpta.2026.101106

Aaushi Pareek , Arpita Sahu , Pooja Malani , Anil Chuturgoon , Ashutosh Pareek

{"title":"Recent advances in Konjac Glucomannan-based self-healing hydrogels for effective wound management","authors":"Aaushi Pareek , Arpita Sahu , Pooja Malani , Anil Chuturgoon , Ashutosh Pareek","doi":"10.1016/j.carpta.2026.101106","DOIUrl":"10.1016/j.carpta.2026.101106","url":null,"abstract":"<div><div>The skin has an intrinsic capacity for regeneration and serves as a critical barrier against microbial invasion, mechanical damage, and environmental stress; this function is compromised in acute and chronic wounds, necessitating effective strategies for rapid repair. Hydrogel‑based dressings have gained prominence because they can absorb exudates, maintain a moist microenvironment, and support tissue regeneration. Konjac glucomannan (KGM), a biocompatible and biodegradable polysaccharide, has been increasingly explored as a matrix for advanced wound dressings due to its hydrophilicity and chemically tunable hydroxyl-rich backbone. Recent studies have reported KGM-based self-healing hydrogels constructed through reversible non-covalent interactions (for example, hydrogen bonding and metal coordination) and dynamic covalent linkages (including Schiff base and acylhydrazone bonds). These dynamic networks enable fast recovery after mechanical disruption, improving durability, injectability, and conformability on irregular or mechanically stressed wound sites. In parallel, KGM-based composite hydrogels integrating nanoparticles, exosomes, and antimicrobial agents have been developed to improve infection, oxidative stress, and impaired angiogenesis in complex wound microenvironments. This review summarises recent advances in the design, fabrication and biological performance of KGM-based self-healing hydrogels across acute and chronic wound models, and highlights key material-design challenges and translational considerations that should guide future technology development and clinical translation.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"13 ","pages":"Article 101106"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0