Carbohydrate Polymer Technologies and Applications最新文献_第5页

Carboxymethyl chitosan oligosaccharide prevents the progression of chronic kidney disease as a Nrf2-dependent apoptosis inhibitor

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100728

Xiaozheng Yuan , Huan He , Youtao Xu, Xinru Chen, Jiawen Wu, Xianpeng Zhong, Xiyu Li, Jing Qiao

{"title":"Carboxymethyl chitosan oligosaccharide prevents the progression of chronic kidney disease as a Nrf2-dependent apoptosis inhibitor","authors":"Xiaozheng Yuan , Huan He , Youtao Xu, Xinru Chen, Jiawen Wu, Xianpeng Zhong, Xiyu Li, Jing Qiao","doi":"10.1016/j.carpta.2025.100728","DOIUrl":"10.1016/j.carpta.2025.100728","url":null,"abstract":"<div><div>Chronic Kidney Disease (CKD) has become a global public health problem, for which satisfactory treatments remain an urgent need. Carboxymethyl chitosan oligosaccharide (CMCOS) is a small molecule derivative of the natural product chitin, which is easy to absorb with variety of biological activities. Our previous research has demonstrated the renal protective effects of CMCOS, while the underlying mechanism is poorly understood. This study reports that the renal protective effects of CMCOS are associated with anti-apoptosis in glomerular podocytes and renal tubular epithelial cells, which maintains the integrity of renal structure and function. Furthermore, CMCOS suppresses tissue oxidative stress and intracellular accumulation of reactive oxygen species both in vitro and in vivo, demonstrating positive correlations with its apoptosis inhibition. Mechanistically, CMCOS enhances endogenous antioxidant defense and relieves oxidative stress in the renal microenvironment through activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Specific inhibition of Nrf2 abolishes the apoptosis-inhibitory effect of CMCOS, indicating a dependence on this pathway. In conclusion, CMCOS activates Nrf2/HO-1 signaling pathway to inhibited oxidative stress-related apoptosis in renal parenchymal cells, thereby alleviating the progression of CKD. Our findings provide a new basis for the medicinal development of carbohydrates.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100728"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored biopolymer films based on cellulose acetate and cobalt ferrite nanoparticles: Dye adsorption and antimicrobial activity

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100716

Mohamed S. Hasanin , Miroslawa El Fray , O.A. Al-Qabandi , Mohamed Bassyouni , N. Almutlaq , Qihui Zhou , Tomy Muringayil Joseph , Monica Toderaș , Sherief A. Al Kiey

{"title":"Tailored biopolymer films based on cellulose acetate and cobalt ferrite nanoparticles: Dye adsorption and antimicrobial activity","authors":"Mohamed S. Hasanin , Miroslawa El Fray , O.A. Al-Qabandi , Mohamed Bassyouni , N. Almutlaq , Qihui Zhou , Tomy Muringayil Joseph , Monica Toderaș , Sherief A. Al Kiey","doi":"10.1016/j.carpta.2025.100716","DOIUrl":"10.1016/j.carpta.2025.100716","url":null,"abstract":"<div><div>In this work, easy-collect adsorbent strips were developed based on the inclusion of cellulose acetate and poly(ԑ-caprolactone) (CA/PCL) as a template for cobalt ferrite nanoparticles (CoFe<sub>2</sub>O<sub>4</sub>NPs) with different concentrations (1, 3, and 5 %). The formulated strips and their parent components were characterized using FTIR and XRD. In addition, topographical analysis, including TEM for CoFe<sub>2</sub>O<sub>4</sub>NPs and SEM and EDX, was performed for formulated strips. The kinetics and the isotherm models were applied to explain the adsorption mechanism. The antimicrobial activity of the formulated strips was studied against the popular water-contaminated microorganism strains. The antimicrobial activity of the strips was presented as a broad spectrum antibacterial activity, and antifungal activity against unicellular and filaments was increased in parallel with CoFe<sub>2</sub>O<sub>4</sub>NPs concentration. The kinetics and isotherm models emphasized that the cationic dye was fitted with a pseudo-first-order and that the anionic dye was fitted with a pseudo-second-order. Moreover, the Langmuir and Freundlich isotherm models were fitted to cationic and anionic dyes. CA/PCL@CoFe<sub>2</sub>O<sub>4</sub>NPs (5 %) stripe recorded q<sub>m</sub> as 1567 and 908 mg g<sup>-1</sup> for methylene blue (MB) and methyl orange (MO), respectively. These findings recommended these stripes for multi-dye adsorption.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100716"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing the application of chitosan in the pharmaceutical field

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2024.100597

Luca Casettari

引用次数: 0

Cellulose oligomer synthesis: Primer effects on structural characteristics in the cellodextrin phosphorylase-catalyzed reverse reaction 纤维素低聚物的合成：引物对纤维糊精磷酸化酶催化的反向反应结构特征的影响

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100731

Tatsuhiro Konishi , Atsushi Sasaki , Ryosuke Kusumi , Masahisa Wada , Kayoko Kobayashi

{"title":"Cellulose oligomer synthesis: Primer effects on structural characteristics in the cellodextrin phosphorylase-catalyzed reverse reaction","authors":"Tatsuhiro Konishi , Atsushi Sasaki , Ryosuke Kusumi , Masahisa Wada , Kayoko Kobayashi","doi":"10.1016/j.carpta.2025.100731","DOIUrl":"10.1016/j.carpta.2025.100731","url":null,"abstract":"<div><div>The synthesis of cellulose oligomers catalyzed by cellodextrin phosphorylase (CDP) can easily yield microcrystals with functional groups exposed on their surfaces using glucose derivatives with various functional groups at the C1 position as primers. In this study, we examined and compared the effects of primers with various structures on the structural characteristics of the resulting synthetic products. The yield of the synthetic products positively correlated with the CDP activity toward the primer, whereas the degree of polymerization (DP) and molecular weight distribution showed an inverse correlation. However, deviations from these trends were observed, suggesting the influence of varying solubilities and crystallization behaviors due to the introduction of functional groups. The obtained microcrystals exhibited a primarily plate-like shape with a thickness increasing in proportion to the DP, resulting in larger plate-like crystals at higher DP values. These findings provide insights into strategies for controlling the structure of the resulting cellulose oligomers.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100731"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amorphous calcium phosphate reinforced alginate-dialdehyde-gelatin (ADA-GEL) bioink for biofabrication of bone tissue scaffolds

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100710

Abhishek Indurkar , Susanne Heid , Julian Bauer , Kristaps Rubenis , Oliver Friedrich , Janis Locs , Aldo R. Boccaccini

{"title":"Amorphous calcium phosphate reinforced alginate-dialdehyde-gelatin (ADA-GEL) bioink for biofabrication of bone tissue scaffolds","authors":"Abhishek Indurkar , Susanne Heid , Julian Bauer , Kristaps Rubenis , Oliver Friedrich , Janis Locs , Aldo R. Boccaccini","doi":"10.1016/j.carpta.2025.100710","DOIUrl":"10.1016/j.carpta.2025.100710","url":null,"abstract":"<div><div>The aim of this work was to develop a nanocomposite bioink closely resembling the nanostructure of bone incorporating amorphous calcium phosphate (ACP) as an inorganic counterpart, specifically, citrate stabilized ACP (ACP_CIT) and non-stabilized ACP (ACP_ACE) in an organic hydrogel matrix consisted of alginate dialdehyde-gelatin (ADA-GEL). The hydrogel's physical properties were evaluated, confirming the reinforcement effect of ACP. The frequency sweep analysis showed that G' and G\" of ADA-GEL were 99 ± 9 Pa and 9 ± 1 Pa, respectively. By the addition of ACP_ACE, G' and G\" increased. Overall, the viscoelastic and mechanical properties of ADA-GEL hydrogel were enhanced by ACP. ACP_CIT was more effective than ACP_ACE. Further, printing parameters were optimized. The bioink was formulated by embedding MC3T3-E1 cells in ADA-GEL and ACP-reinforced ADA-GEL hydrogels, followed by fabricating scaffolds at optimized printing parameters (pressure: 65 kPa, speed: 5 mm/s). Crosslinking was performed by immersing constructs in CaCl<sub>2</sub> and microbial transglutaminase solution. Post-printing analysis was performed using the printability index and average pore area analysis. The lowest structural stability was observed in ADA-GEL constructs. The highest structural stability was noted in ADA-GEL-ACP_CIT constructs. Epifluorescence and two-photon microscopy of Rhodamine/Phalloidin stained constructs confirmed the cytocompatibility of the bioinks.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100710"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxyapatites and nano-hydroxyapatites as scaffolds in drug delivery towards efficient bone regeneration: A review

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100692

Amir Hatami kaleshtari , Samira Farjaminejad , Melika Hasani , Rosana Farjaminejad , Amin Foroozandeh , Majid Abdouss , Mohammad Hasanzadeh

{"title":"Hydroxyapatites and nano-hydroxyapatites as scaffolds in drug delivery towards efficient bone regeneration: A review","authors":"Amir Hatami kaleshtari , Samira Farjaminejad , Melika Hasani , Rosana Farjaminejad , Amin Foroozandeh , Majid Abdouss , Mohammad Hasanzadeh","doi":"10.1016/j.carpta.2025.100692","DOIUrl":"10.1016/j.carpta.2025.100692","url":null,"abstract":"<div><div>Bone regeneration is a complex process that requires materials capable of supporting structural integrity, promoting cell proliferation, and enabling effective drug delivery. Nano-hydroxyapatite (nHA), with its biocompatibility and close resemblance to natural bone minerals, has emerged as a promising material in bone tissue engineering. nHA enhances osteoconductivity, mechanical strength, and drug-loading capacity, making it an effective tool for treating bone defects. Therefore, the potential of combining nHA with bioactive agents and polymers offers new opportunities for long-term, targeted treatments for bone diseases and injuries. This review highlights the role of nHA in drug-delivery systems for bone regeneration, focusing on its properties, synthesis methods, and interactions with bone tissue. Then, key challenges include optimizing scaffold porosity, controlling degradation rates, and improving mechanical stability. Next, advanced applications, such as gene therapy and intelligent drug delivery systems, are also explored. Additionally, some research gaps on the utilization of nHA in drug delivery of bone regeneration were surveyed. Finally, future perspectives on the nHA-based scaffolds for smart drug delivery in the reconstruction and repair of bone were discussed.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100692"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbohydrate polymers, fibers, and oligomers as surgical sutures and wound dressings

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100725

Jayantrao Shinde

引用次数: 0

Microwave assisted extraction of chitosan from Agaricus bisporus: techno-functional and microstructural properties 微波辅助提取双孢蘑菇壳聚糖：技术功能和微观结构特性

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-03-01 DOI: 10.1016/j.carpta.2025.100730

Adity Bahndral , Rafeeya Shams , Kshirod Kumar Dash , Pintu Chaudhary , Ayaz Mukarram Shaikh , Kovács Béla

{"title":"Microwave assisted extraction of chitosan from Agaricus bisporus: techno-functional and microstructural properties","authors":"Adity Bahndral , Rafeeya Shams , Kshirod Kumar Dash , Pintu Chaudhary , Ayaz Mukarram Shaikh , Kovács Béla","doi":"10.1016/j.carpta.2025.100730","DOIUrl":"10.1016/j.carpta.2025.100730","url":null,"abstract":"<div><div>Chitosan, a copolymer of glucosamine and N-acetyl glucosamine, is primarily derived from chitin. The present research was conducted to generate and analyze chitosan derived from white button mushroom waste (<em>Agaricus bisporus</em>) using microwave assisted extraction. Dried mushroom waste powder was demineralized in diluted acid using 3 M HCl in 1:10 w/v at 540 W for 8 min and deproteinated at 180 W using 10% NaOH in 1:10 w/v for 8 min to remove proteins and lipids. The extracted chitin was deacetylated using 50% NaOH in 1:20 w/v at 360 W to convert it into chitosan. Chitin from the aforesaid process was deacetylated in concentrated alkaline medium at 360 W for 8 min to yield chitosan by converting acetyl groups to -NH<sub>2</sub> groups. The pH and solubility of fresh chitosan were 7.5 and 75%, respectively. Extracted chitosan had maximum 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity of 53.97% and reducing power of 3.58. The microwave irradiation method produced chitosan having degree of deacetylation of 79.94% and crystallinity index of 1.09. The spectra bands confirmed existence of NH<sub>2</sub>, OH, C<img>O, CH, and C<img>N functional groups. The X-ray diffraction analysis of the chitosan sample discovered distinct peaks at 2θ values between 10 and 20 °, indicating its semi-crystalline nature.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100730"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun poly-ε-caprolactone fibers loaded with inclusion complex of sulfobutyl ether β-cyclodextrin with dexamethasone as potential drug release systems

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-02-28 DOI: 10.1016/j.carpta.2025.100726

Larisa Kobrina , Anton Tymoshyk , Mykola Monastyretskyi , Valentyna Boiko , Sergiy Polishchuk , Sergii Sinelnikov , Dmytro Klymchuk , Sergii Riabov

{"title":"Electrospun poly-ε-caprolactone fibers loaded with inclusion complex of sulfobutyl ether β-cyclodextrin with dexamethasone as potential drug release systems","authors":"Larisa Kobrina , Anton Tymoshyk , Mykola Monastyretskyi , Valentyna Boiko , Sergiy Polishchuk , Sergii Sinelnikov , Dmytro Klymchuk , Sergii Riabov","doi":"10.1016/j.carpta.2025.100726","DOIUrl":"10.1016/j.carpta.2025.100726","url":null,"abstract":"<div><div>The research focuses on the developing of electrospun poly-ε-caprolactone (PCL) fibers (mats) loaded with inclusion complex of sulfobutyl ether β-cyclodextrin sodium salt (SB-β-CD) with dexamethasone (Dex) as a known anti-inflammatory drug, and studying their structural characteristics and desorption properties in vitro (in saline and water solution). Initially, inclusion complex of SB-β-CD with Dex was prepared and complexation between these components was confirmed by FTIR-spectroscopy, differential scanning calorimetry, X-ray diffraction and thermal mass spectrometry. Both neat PCL fibers (mats) and those filled with the inclusion complex were produced via electrospinning technique from chloroform-DMSO solutions. PCL films and the films with incorporated inclusion complex as a references for comparison were casted from the same solvents. Features of the structural, morphological, thermophysical of the electrospun PCL mats were analyzed by XRD, scanning electron microscopy, DSC, and desorption behavior as well. >80 % of the fibers obtained have diameters in the range of 180–400 nm and the average diameter of unloaded fibers is found to be 380.47 nm, which is almost 2.5 times smaller than in loaded fibers. The data of the drug release kinetics evidence that the desorption of dexamethasone from PCL matrix is significantly accelerated in saline compared to the release this drug in water. The elaborated nanofiber materials could be considered as potential objects for further investigations as drug release systems.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100726"},"PeriodicalIF":6.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclodextrin metal-organic framework for efficient adsorption of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) residues from cultured meat

IF 6.2

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-02-26 DOI: 10.1016/j.carpta.2025.100727

Tahirou Sogore , Meimei Guo , Na Sun , Donglei Jiang , Donghong Liu , Mofei Shen , Tian Ding

{"title":"Cyclodextrin metal-organic framework for efficient adsorption of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) residues from cultured meat","authors":"Tahirou Sogore , Meimei Guo , Na Sun , Donglei Jiang , Donghong Liu , Mofei Shen , Tian Ding","doi":"10.1016/j.carpta.2025.100727","DOIUrl":"10.1016/j.carpta.2025.100727","url":null,"abstract":"<div><div>Cultured meat offers a promising solution to meet global protein demand using stem cells rather than traditional animal agriculture. The production relies on gel-based scaffold materials, requiring photoinitiators like lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) for crosslinking and forming the three-dimensional matrix. However, LAP residues in the final product pose potential health risks, necessitating efficient detection and removal strategies. In this study, we analyzed cultured fish meat samples, revealing LAP residues, then prepared an eco-friendly CD-MOF from edible materials and demonstrated its excellent LAP adsorption capabilities. The adsorption quantity was investigated using high-performance liquid chromatography (HPLC), and the method's versatility was validated by expanding the study to 2-Hydroxy-4′-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and 2,2-dimethoxy-2-phenylacetophenone (Irgacure 651). CD-MOF achieved maximum adsorption rates of 88.19 ± 3.65 mg/g for LAP, 60.88 ± 3.51 mg/g for Irgacure 2959, and 56.52 ± 3.28 mg/g for Irgacure 651. Spiked recoveries in cultured meat samples ranged from 84.36 % to 98.78 %, with RSDs between 2.16 % and 6.87 %, demonstrating high precision. These findings suggest CD-MOF's promise for detecting and removing photoinitiator residues in cultured meat production.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100727"},"PeriodicalIF":6.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0