Synthesis and characterization of zeolitic imidazolate framework-8 -MOF hybrid bionanocomposite based on Alyssum homolocarpum hydrogel

A new hybrid bionanocomposite (HBNC) was successfully synthesized by adding 25 mg Zeolitic imidazolate framework-8 (ZIF-8), a zinc-based metal-organic framework (MOF), into a 1% A. homolocarpum seeds gum (AHSG) solution (MOF@AHSG-HBNC). Both FESEM and TEM confirmed that Zn-MOF were successfully incorporated into the hydrogel. The average zeta potential values of MOF@AHSG-HBNC and Zn-MOF were -44.93 ± 2.19 and 27.45 ± 1.08 mV, respectively. FTIR and XRD results confirming successful creation of MOF@AHSG-HBNC. The Vibrating-sample magnetometry (VSM) revealed the ferromagnetism of the bionanocomposite. The results also illustrated the radical scavenging capacity for both Zn-MOF and the bionanocomposite increasing from 28.47 ± 3.01 to 82.01± 5.37% and from 6.58 ± 0.31% to 38.51± 2.69%, respectively, as the concentration increased from 125 to 1000 μg.mL^-1. Zn-MOF and bionanocomposite showed 2, 2-diphenyl-1-picrylhydrazyl (DPPH) with the half-maximal inhibitory concentration (IC₅₀) values of 286.94 and 1313.48 μg.mL^-1, respectively, and anti-inflammatory IC₅₀ values of 1507.74 ± 0.41 μg.mL^-1 and 3288.42 ± 1.66 μg. mL^-1. The gram-positive bacteria were more susceptible to Zn-MOF. As Zn-MOF was integrated in the hydrogel, no antibacterial effect was observed in MOF@AHSG-HBNC. The weight loss percentage and the degradation rate of the hybrid bionanocomposite were 13% during 5 h and 22% during 300 h, respectively.