BMEMat Pub Date : 2024-04-24 DOI: 10.1002/bmm2.12076

Shuai Guo, Hui Tang, Yahui Zhang, Zhouyu Wang, Swee Ching Tan

引用次数: 0

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection 基于感染响应性多糖的载药纳米组件，用于抗耐药细菌肺部感染的双模式治疗

BMEMat Pub Date : 2024-04-24 DOI: 10.1002/bmm2.12082

Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu

{"title":"Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection","authors":"Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu","doi":"10.1002/bmm2.12082","DOIUrl":"10.1002/bmm2.12082","url":null,"abstract":"The escalating issue of lung infections induced by multi-drug resistant (MDR) bacteria is threatening human health. Thus, the development of efficient drug delivery systems is essential to eliminate MDR bacterial lung infections effectively. Herein, we designed inhalable drug-loaded nano-assemblies by the electrostatic interaction between negatively charged sodium alginate and a positively charged antibacterial polymer, quaternized polyethyleneimine (QPEI-C6), as well as a kind of typical antibiotic for therapy of lung infection, azithromycin (AZT). By adjusting the feed ratios, we optimized the size of the nano-assembly to approximately 200 nm (STQ12), which was beneficial for penetration through the mucus layer and biofilm. In the slightly acidic environment of the infected site, the nano-assembly could dissemble responsively and release AZT and QPEI-C6. Because of the combined bactericidal effect, STQ12 exhibited high bactericidal efficiency against MDR bacteria. In animal experiments, STQ12 showed notable efficacy against MDR bacterial lung infection. Gene transcriptomic results showed that the main effects of STQ12 against bacteria were through influencing the bacterial cell components and metabolic processes, and affecting their growth and reproduction. This work provides a promising strategy to treat MDR bacterium-induced lower respiratory tract infections.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of a nonclassical liposomal nanoscale drug delivery system for innovative cancer therapy 合理设计用于创新癌症疗法的非经典脂质体纳米级给药系统

BMEMat Pub Date : 2024-04-15 DOI: 10.1002/bmm2.12083

Chunjie Wang, Xiaoqi Sun, Liangzhu Feng, Zhuang Liu

{"title":"Rational design of a nonclassical liposomal nanoscale drug delivery system for innovative cancer therapy","authors":"Chunjie Wang, Xiaoqi Sun, Liangzhu Feng, Zhuang Liu","doi":"10.1002/bmm2.12083","DOIUrl":"10.1002/bmm2.12083","url":null,"abstract":"Advanced drug delivery systems are widely considered to be powerful approaches for treating cancer and many other diseases because of their superior ability to improve pharmacokinetics, promote lesion-targeted delivery efficacy, and/or reduce the toxic effects of diverse therapeutics. Owing to the unique biomimetic structure of lipid bilayers surrounding aqueous cavities, liposomes have been found to encapsulate various therapeutics, ranging from small molecules with different hydrophobicities to biomacromolecules. With the advent of surface PEGylation, stealth liposomes with excellent in vivo long-circulating behaviors have been generated, thus these liposomes have been extensively explored for the development of liposomal drugs with greatly improved in vivo pharmacokinetic behaviors by functioning as delivery vehicles. Inspired by their successes in clinical practice, stealth liposomes have recently been utilized as the main building scaffold or surface coating layers of other nanoparticulate formulations, which are coined as nonclassical liposomal nanoscale drug delivery systems (NDDSs) in this review, to enable the rational design of next-generation liposomal nanomedicine. Therefore, after overviewing the latest progress in the development of conventional liposome-based nanomedicine, we will introduce the development of these nonclassical liposomal NDDSs as well as their innovative cancer treatment strategies. We will subsequently provide a critical perspective on the future development of new cancer nanomedicines based on these rationally designed nonclassical liposomal NDDSs.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for co‐immobilization of multiple enzymes 共同固定多种酶的纳米材料

BMEMat Pub Date : 2024-03-12 DOI: 10.1002/bmm2.12080

Jingyu Zhang, Jonathan F. Lovell, Jiafu Shi, Yumiao Zhang

引用次数: 0

Regulated cell death-amplified sonodynamic anti-tumor immune nanotherapeutics

BMEMat Pub Date : 2024-03-04 DOI: 10.1002/bmm2.12079

Liqiang Zhou, Yangmengfan Chen, Dong Xie, Kun Li, Xinwu Cui, Christoph F. Dietrich, Andreas K. Nüssler, Xuanjun Zhang

{"title":"Regulated cell death-amplified sonodynamic anti-tumor immune nanotherapeutics","authors":"Liqiang Zhou, Yangmengfan Chen, Dong Xie, Kun Li, Xinwu Cui, Christoph F. Dietrich, Andreas K. Nüssler, Xuanjun Zhang","doi":"10.1002/bmm2.12079","DOIUrl":"https://doi.org/10.1002/bmm2.12079","url":null,"abstract":"Nanomedicine-assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages of high penetration, non-radiation, and excellent oxidative stress effect, but has always suffered from the self-protection mechanism and apoptosis resistance characteristics of evolutionarily mutated cancer cells. Regulated cell death (RCD) has received increasing attention in precision cancer treatments because of its significant role in synergistically sensitizing apoptosis and reversing the immunosuppressive microenvironment during SDT nanomedicine-triggered immunogenic cell death. Herein, paradigmatic research of RCD-augmented sonodynamic tumor immunotherapeutics are typically introduced, such as autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, and the coordinated anti-tumor mechanisms are discussed in detail. Multiple analysis focusing on the currently unsolved problems and future development prospects of RCD-based SDT nano-oncology medicine are also discussed and prospected to further strengthen and expand the scope of its therapeutic applications.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired photonic crystals: Tailoring the dielectric building blocks to control the light propagation (1/2024) 生物启发光子晶体：定制电介质构件以控制光传播 (1/2024)

BMEMat Pub Date : 2024-03-01 DOI: 10.1002/bmm2.12073

Cun Zhu, Lei Tian, Wei Cheng, Zhongze Gu

引用次数: 0

Magnetic hydroxyapatite nanobelt-stem cell hybrid spheroids for remotely patterning bone tissues (1/2024) 磁性羟基磷灰石纳米带-干细胞杂交球体用于远程模式化骨组织 (1/2024)

BMEMat Pub Date : 2024-03-01 DOI: 10.1002/bmm2.12074

Min Hao, Wenhan Wang, Anil Kumar, Wan Hairul Anuar Kamaruddin, Syafiqah Saidin, Nik Ahmad Nizam Nik Malek, Jerome Claverie, Hong Liu

引用次数: 0

Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti-inflammation, and regeneration 用于改善骨关节炎的水凝胶：机械调节、抗炎和再生

BMEMat Pub Date : 2024-03-01 DOI: 10.1002/bmm2.12078

Xuwei Jiang, Yuxiang Sun, Yuanning Lyu, Heemin Kang, Jianyang Zhao, Kunyu Zhang, Liming Bian

{"title":"Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti-inflammation, and regeneration","authors":"Xuwei Jiang, Yuxiang Sun, Yuanning Lyu, Heemin Kang, Jianyang Zhao, Kunyu Zhang, Liming Bian","doi":"10.1002/bmm2.12078","DOIUrl":"10.1002/bmm2.12078","url":null,"abstract":"Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis and develop treatments against OA. Hydrogels, designed with a striking resemblance to the extracellular matrix, offer a biomimetic interaction with biological tissues, presenting a promising avenue for OA amelioration. As a result, biocompatible hydrogels have been erected incorporating on-demand bioactivities to optimize the intra-articular microenvironment, thereby alleviating OA symptoms and fostering the eventual regeneration of articular joints. This review highlights the collaborative objectives underlying the establishment of this tissue microenvironment, encompassing mechanical modulation, anti-inflammation, and tissue regeneration. Specifically, we consolidate recent advances in hydrogel-based biomaterials, serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent-loaded vehicles to combat localized inflammation. Additionally, hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage regeneration. Finally, this review outlines the prospective directions for hydrogel-mediated OA therapies.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy 金属配位驱动组装用于肿瘤化疗免疫疗法的干扰素基因激活剂纳米粒子

BMEMat Pub Date : 2024-02-27 DOI: 10.1002/bmm2.12077

Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui

{"title":"Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy","authors":"Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui","doi":"10.1002/bmm2.12077","DOIUrl":"10.1002/bmm2.12077","url":null,"abstract":"Activating the stimulator of interferon genes (STING) signaling pathway is critical for enhancing antitumor immunity and remodeling the immunosuppressive tumor microenvironment (TME). Herein, we report the preparation of STING-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist (i.e., SR717) and a chemotherapeutic drug (i.e., curcumin). After intravenous administration, the assembled nanoparticles could efficiently accumulate in tumors to improve the bioavailability of SR717 and trigger potent STING pathway activation for effective immune responses. Meanwhile, the released curcumin evokes immunogenic cell death in tumors and regulates amino acid metabolism by inhibiting the activation of indoleamine 2,3-dioxygenase 1, leading to the reversal of the immunosuppressive TME. The antitumor immunity induced by nanoparticles significantly inhibits the growth of primary, recurrent, and metastatic tumors. The assembled nanoparticles are promising for the co-delivery of STING agonists and drugs in improved tumor chemo-immunotherapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of novel carbon-based biomedical platforms for intervention in xenotoxicant-induced Parkinson's disease onset 开发新型碳基生物医学平台，用于干预异毒素诱发的帕金森病发病

BMEMat Pub Date : 2024-01-27 DOI: 10.1002/bmm2.12072

Jyotish Kumar, Armando Varela-Ramirez, Mahesh Narayan

{"title":"Development of novel carbon-based biomedical platforms for intervention in xenotoxicant-induced Parkinson's disease onset","authors":"Jyotish Kumar, Armando Varela-Ramirez, Mahesh Narayan","doi":"10.1002/bmm2.12072","DOIUrl":"10.1002/bmm2.12072","url":null,"abstract":"Chronic exposure to herbicides, weedicides, and pesticides is associated with the onset and progress of neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Here, we have investigated whether quinic- and chlorogenic-acid-derived Carbon Quantum Dots (QACQDs and ChACQDs, respectively) protect against a (pesticide) paraquat-insult model of PD. Our results indicated that both types of CQDs intervened in the soluble-to-toxic transformation of the amyloid-forming model protein Hen Egg White Lysozyme (HEWL). Furthermore, QACQDs and ChACQDs demonstrated antioxidant activity while remaining biocompatible in a human neuroblastoma-derived cell line (SH-SY5Y) up to 5 mg/ml and protected the cell line from the environmental neurotoxicant (paraquat). Importantly, both CQDs were found to protect dopaminergic neuronal ablation in a paraquat model of Parkinson's disease using the nematode C. elegans. Our results are significant because both plant-derived organic acids cross the blood–brain barrier, making them attractive for developing CQD architectures. Furthermore, since the synthesis of these CQDs was performed using green chemistry methods from precursor acids that cross the BBB, these engineered bionanomaterial platforms are tantalizing candidates for preventing neurodegenerative disorders associated with exposure to environmental neurotoxicants.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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