{"title":"Is deep brain imaging on the brink of transformation with a bioluminescence molecule?","authors":"Shumao Xu, Farid Manshaii, Jun Chen","doi":"10.1002/bmm2.12115","DOIUrl":null,"url":null,"abstract":"<p>Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12115","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMEMat","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bmm2.12115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
