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Reverse thinking: Tumor nutritional therapy 逆向思维肿瘤营养疗法
BMEMat Pub Date : 2024-07-20 DOI: 10.1002/bmm2.12114
Binbin Ding, Ping’an Ma, A. A. A. Kheraif, Jun Lin
{"title":"Reverse thinking: Tumor nutritional therapy","authors":"Binbin Ding, Ping’an Ma, A. A. A. Kheraif, Jun Lin","doi":"10.1002/bmm2.12114","DOIUrl":"https://doi.org/10.1002/bmm2.12114","url":null,"abstract":"Tumor cells often exhibit metabolic abnormalities to meet the needs of rapid proliferation, and targeting tumor metabolism has become one of the effective strategies for cancer treatment. However, most of the current methods targeting metabolism focus on inhibiting hyperactivated metabolic pathways, hindering their further application. A recent innovative work, proposed a nutrient‐based strategy to reactivate metabolism for tumor therapy by targeting suppressed metabolic pathways. This approach through delivering nutrients to tumor cells directly using nanotechnology indicates that specific nutrients can serve as potent activators of metabolic pathways. As a new direction along the reverse thinking, this study suggests that this nutrient‐based metabolism reactivation strategy will inspire broad applications in the treatment of other diseases associated with metabolic disorders, besides tumor.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano/genetically engineered cells for immunotherapy 用于免疫疗法的纳米/基因工程细胞
BMEMat Pub Date : 2024-07-17 DOI: 10.1002/bmm2.12112
Jingrui Shen, Yang Zhou, Lichen Yin
{"title":"Nano/genetically engineered cells for immunotherapy","authors":"Jingrui Shen, Yang Zhou, Lichen Yin","doi":"10.1002/bmm2.12112","DOIUrl":"https://doi.org/10.1002/bmm2.12112","url":null,"abstract":"Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such as cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency and off‐target toxicity of immunotherapeutic drugs. Nano drug delivery systems offer improvements in drug biodistribution and release kinetics but still suffer from shortcomings such as high immunogenicity, poor penetration across biological barriers, and insufficient tissue permeability. Targeted delivery of drugs using living cells has become an emerging strategy that can take advantage of the inherent characteristics of cells to deal with the delivery defects of nano delivery systems. Furthermore, cells themselves can be genetically engineered into cellular drugs for enhanced immunotherapy. This review provides an in‐depth exploration of cell‐derived drug carriers, detailing their biological properties, functions, and commonly used drug loading strategies. In addition, the role of genetically modified cells in immunotherapy and their synergistic therapeutic effects with drug delivery are also introduced. By summarizing the main advancements and limitations in the field, this review offers insights into the potential of cell‐based drug delivery systems to address the existing challenges in immunotherapy. The introduction to recent developments and evaluation of ongoing research will pave the way for the optimization and widespread adoption of nano/genetically engineered cells for immunotherapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue clearing and its application in dental research 组织清理及其在牙科研究中的应用
BMEMat Pub Date : 2024-07-15 DOI: 10.1002/bmm2.12113
Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang
{"title":"Tissue clearing and its application in dental research","authors":"Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang","doi":"10.1002/bmm2.12113","DOIUrl":"https://doi.org/10.1002/bmm2.12113","url":null,"abstract":"For both animal and human tissues, translucence is an intrinsic property that gives them a milky appearance. This optical property arises due to the combined effects of light absorption and scattering and becomes the main impediment of deep imaging. To overcome these obstacles, the tissue‐clearing technique has experienced a resurgence over the past century and evolved from its initial use in neuroscience to encompass various samples due to the emergence of various clearing methods. Notably, these techniques unveil both macroscopic and microscopic details, offering valuable insights into tissue structures. In particular, the oral cavity is structured with both soft and hard tissues at the macroscopic level and is rich in neurovascular networks microscopically, providing a suitable application environment for tissue‐clearing techniques. Currently, tissue‐clearing techniques have provided a powerful tool for research on the dental pulp neurovascular system, oral tissue regeneration, dental implants, and maxillofacial surgical treatments. Hence, this review aims to give a general introduction to tissue‐clearing techniques and focus on their remarkable applications in dental research. At last, we will discuss the integration of tissue‐clearing methods with other techniques such as labeling and microscopy, hoping to offer valuable insights for the development of tissue‐clearing techniques in both bioscience and materials science.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy (2/2024) 金属配位驱动组装用于肿瘤化疗免疫疗法的干扰素基因激活纳米颗粒 (2/2024)
BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12106
Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui
{"title":"Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy (2/2024)","authors":"Guiqiang Zhang,&nbsp;Ning Wang,&nbsp;Yuan Ma,&nbsp;Shumei Zhai,&nbsp;To Ngai,&nbsp;Shilei Ni,&nbsp;Xinyi Jiang,&nbsp;Jianwei Jiao,&nbsp;Jiwei Cui","doi":"10.1002/bmm2.12106","DOIUrl":"https://doi.org/10.1002/bmm2.12106","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12077, Guiqiang Zhang, Ning Wang and their co-workers developed stimulator of interferon genes (STING)-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist and a phenolic chemotherapeutic drug. These nanoparticles could efficiently accumulate in tumors, leading to potent STING pathway activation, induction of immunogenic cell death, and regulation of amino acid metabolism. The antitumor immunity induced by nanoparticles could significantly inhibit the growth of primary, recurrent, and metastatic tumors, providing a novel paradigm for tumor chemo-immunotherapy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines (2/2024) 基于聚合物纳米药物的癌症联合免疫疗法的先进战略 (2/2024)
BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12107
Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li, Chao Feng, Lei Wang, Kuikun Yang
{"title":"Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines (2/2024)","authors":"Kaisheng You,&nbsp;Qi Wang,&nbsp;Mohamed Syazwan Osman,&nbsp;Dongpyo Kim,&nbsp;Qian Li,&nbsp;Chao Feng,&nbsp;Lei Wang,&nbsp;Kuikun Yang","doi":"10.1002/bmm2.12107","DOIUrl":"https://doi.org/10.1002/bmm2.12107","url":null,"abstract":"<p>Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines have been timely, concisely and fully discussed in this article number 10.1002/bmm2.12067, with an outlook on the current challenges and potential solutions.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications 用于生物医学应用的仿贻贝多糖注射水凝胶
BMEMat Pub Date : 2024-05-24 DOI: 10.1002/bmm2.12089
Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang
{"title":"Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications","authors":"Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang","doi":"10.1002/bmm2.12089","DOIUrl":"https://doi.org/10.1002/bmm2.12089","url":null,"abstract":"With high biocompatibility and degradability, polysaccharide‐based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials are inconvenient to handle with fixed morphology, unable to closely match the wounds, and easy to detach due to insufficient adhesion. Inspired by the superior wet adhesive properties of marine mussels, researchers have used mussel‐inspired chemistry to create mussel‐mimetic injectable polysaccharide‐based hydrogels that are simple to operate, controllable in shape, and highly adhesive, and have significantly extended their applications such as tissue adhesives, delivery vehicles, tissue engineering scaffolds, and wearable sensors. However, there are few comprehensive reviews on polysaccharide‐based hydrogels with both mussel‐mimetic adhesion and injectability, and few critical analyses of these hydrogels' preparation methods and applications. This review fills this gap and systematically summarizes the preparation strategies for novel mussel‐mimetic injectable polysaccharide‐based hydrogels, including modifying polysaccharides with catechol‐ or pyrogallol‐containing small molecules and leveraging different interactions between catechol‐/pyrogallol‐modified polysaccharides and other substances to form crosslinked hydrogels. Furthermore, recent biomedical applications of injectable catechol‐/pyrogallol‐modified polysaccharide‐based hydrogels are discussed, and their future challenges and research trends are proposed.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intelligent textiles make life wirelessly energetic by coupling radiation energy and human 智能纺织品通过将辐射能量与人类生活相结合，使生活充满无线能量
BMEMat Pub Date : 2024-05-16 DOI: 10.1002/bmm2.12090
Dan Zhou, Zhenfang Zhang, Yitong Li, Tianyi Ma, Haijun He, Haoxuan Li
{"title":"Intelligent textiles make life wirelessly energetic by coupling radiation energy and human","authors":"Dan Zhou,&nbsp;Zhenfang Zhang,&nbsp;Yitong Li,&nbsp;Tianyi Ma,&nbsp;Haijun He,&nbsp;Haoxuan Li","doi":"10.1002/bmm2.12090","DOIUrl":"10.1002/bmm2.12090","url":null,"abstract":"<p>By innovatively coupling human body and functional fibers, recent inspiring research achieves radiation energy capture, signal transmission and digital visualization while retains flexibilities, softness and durability of textiles and their large-scale fabrications. The single coupled human-fiber system provides absolutely new mechanism and fibrous method to design and produce intelligent textiles and promises to offer more potential applications in home and daily lives.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Ferritin-based drug delivery system for tumor therapy” 更正 "基于铁蛋白的肿瘤治疗药物输送系统"
BMEMat Pub Date : 2024-05-14 DOI: 10.1002/bmm2.12092
{"title":"Correction to “Ferritin-based drug delivery system for tumor therapy”","authors":"","doi":"10.1002/bmm2.12092","DOIUrl":"10.1002/bmm2.12092","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.</p><p>This should be corrected to “Xing-Jie Liang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases” 对 "用于预防和治疗心脏病的三电纳米发电机和压电纳米发电机 "的更正
BMEMat Pub Date : 2024-05-14 DOI: 10.1002/bmm2.12094
{"title":"Correction to “Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases”","authors":"","doi":"10.1002/bmm2.12094","DOIUrl":"10.1002/bmm2.12094","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.</p><p>This should be corrected to “Changyong Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for the error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Prosthetic heart valves for transcatheter aortic valve replacement” 更正 "用于经导管主动脉瓣置换术的人工心脏瓣膜"
BMEMat Pub Date : 2024-05-14 DOI: 10.1002/bmm2.12097
{"title":"Correction to “Prosthetic heart valves for transcatheter aortic valve replacement”","authors":"","doi":"10.1002/bmm2.12097","DOIUrl":"10.1002/bmm2.12097","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.</p><p>This should be corrected to “Changyou Gao is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interest.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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