BMEMat最新文献 - Book学术

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair (3/2024) 用于动态组织修复的扩散诱导相分离三维打印支架 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12119

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

引用次数: 0

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024) 基于感染反应多糖的载药纳米组件，用于抗耐药细菌肺部感染的双模式治疗 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12120

Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu

引用次数: 0

Is deep brain imaging on the brink of transformation with a bioluminescence molecule? 利用生物发光分子进行脑深部成像是否即将实现变革？

BMEMat Pub Date : 2024-08-16 DOI: 10.1002/bmm2.12115

Shumao Xu, Farid Manshaii, Jun Chen

引用次数: 0

Reverse thinking: Tumor nutritional therapy 逆向思维肿瘤营养疗法

BMEMat Pub Date : 2024-07-20 DOI: 10.1002/bmm2.12114

Binbin Ding, Ping'an Ma, Abdulaziz A. Al Kheraif, Jun Lin

引用次数: 0

Nano/genetically engineered cells for immunotherapy 用于免疫疗法的纳米/基因工程细胞

BMEMat Pub Date : 2024-07-17 DOI: 10.1002/bmm2.12112

Jingrui Shen, Yang Zhou, Lichen Yin

{"title":"Nano/genetically engineered cells for immunotherapy","authors":"Jingrui Shen, Yang Zhou, Lichen Yin","doi":"10.1002/bmm2.12112","DOIUrl":"https://doi.org/10.1002/bmm2.12112","url":null,"abstract":"Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such as cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency and off‐target toxicity of immunotherapeutic drugs. Nano drug delivery systems offer improvements in drug biodistribution and release kinetics but still suffer from shortcomings such as high immunogenicity, poor penetration across biological barriers, and insufficient tissue permeability. Targeted delivery of drugs using living cells has become an emerging strategy that can take advantage of the inherent characteristics of cells to deal with the delivery defects of nano delivery systems. Furthermore, cells themselves can be genetically engineered into cellular drugs for enhanced immunotherapy. This review provides an in‐depth exploration of cell‐derived drug carriers, detailing their biological properties, functions, and commonly used drug loading strategies. In addition, the role of genetically modified cells in immunotherapy and their synergistic therapeutic effects with drug delivery are also introduced. By summarizing the main advancements and limitations in the field, this review offers insights into the potential of cell‐based drug delivery systems to address the existing challenges in immunotherapy. The introduction to recent developments and evaluation of ongoing research will pave the way for the optimization and widespread adoption of nano/genetically engineered cells for immunotherapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue clearing and its application in dental research 组织清理及其在牙科研究中的应用

BMEMat Pub Date : 2024-07-15 DOI: 10.1002/bmm2.12113

Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang

{"title":"Tissue clearing and its application in dental research","authors":"Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang","doi":"10.1002/bmm2.12113","DOIUrl":"https://doi.org/10.1002/bmm2.12113","url":null,"abstract":"For both animal and human tissues, translucence is an intrinsic property that gives them a milky appearance. This optical property arises due to the combined effects of light absorption and scattering and becomes the main impediment of deep imaging. To overcome these obstacles, the tissue‐clearing technique has experienced a resurgence over the past century and evolved from its initial use in neuroscience to encompass various samples due to the emergence of various clearing methods. Notably, these techniques unveil both macroscopic and microscopic details, offering valuable insights into tissue structures. In particular, the oral cavity is structured with both soft and hard tissues at the macroscopic level and is rich in neurovascular networks microscopically, providing a suitable application environment for tissue‐clearing techniques. Currently, tissue‐clearing techniques have provided a powerful tool for research on the dental pulp neurovascular system, oral tissue regeneration, dental implants, and maxillofacial surgical treatments. Hence, this review aims to give a general introduction to tissue‐clearing techniques and focus on their remarkable applications in dental research. At last, we will discuss the integration of tissue‐clearing methods with other techniques such as labeling and microscopy, hoping to offer valuable insights for the development of tissue‐clearing techniques in both bioscience and materials science.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"15 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair 用于动态组织修复的扩散诱导相分离三维打印支架

BMEMat Pub Date : 2024-06-12 DOI: 10.1002/bmm2.12108

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

{"title":"Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair","authors":"Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi","doi":"10.1002/bmm2.12108","DOIUrl":"10.1002/bmm2.12108","url":null,"abstract":"<p>Many hydrogen-bonded cross-linked hydrogels possess unique properties, but their limited processability hinders their potential applications. By incorporating a hydrogen bond dissociator (HBD) into these hydrogels, we developed injectable 3D printing inks termed diffusion-induced phase separation (DIPS) 3D printing inks. Upon extrusion into water and subsequent diffusion of HBD, these ink cure rapidly. The DIPS-printed scaffold retained most of the original hydrogel properties due to the regeneration of hydrogen bonds. Additionally, the reversible nature of hydrogen bonds provides DIPS 3D-printed scaffolds with exceptional recycling and reprinting capabilities, resulting in a reduction in the waste of valuable raw ink materials or additives. Postprocessing introduces new crosslinking methods that modulate the mechanical properties and degradation characteristics of DIPS scaffolds over a broad range. Based on its suitable mechanical properties and bioactivity, we successfully repaired and functionally reconstructed a complex defect in penile erectile tissue using the DIPS scaffold in a rabbit model. In summary, this approach is relevant for various hydrogen-bonded cross-linked hydrogels that offer mild printing conditions and enable the incorporation of bioactive agents. They can be used as scaffolds for dynamic tissue reconstruction, wearable devices, or soft robots.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy (2/2024) 金属配位驱动组装用于肿瘤化疗免疫疗法的干扰素基因激活纳米颗粒 (2/2024)

BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12106

Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui

引用次数: 0

Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines (2/2024) 基于聚合物纳米药物的癌症联合免疫疗法的先进战略 (2/2024)

BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12107

Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li, Chao Feng, Lei Wang, Kuikun Yang

引用次数: 0

Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications 用于生物医学应用的仿贻贝多糖注射水凝胶

BMEMat Pub Date : 2024-05-24 DOI: 10.1002/bmm2.12089

Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang

{"title":"Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications","authors":"Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang","doi":"10.1002/bmm2.12089","DOIUrl":"https://doi.org/10.1002/bmm2.12089","url":null,"abstract":"With high biocompatibility and degradability, polysaccharide‐based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials are inconvenient to handle with fixed morphology, unable to closely match the wounds, and easy to detach due to insufficient adhesion. Inspired by the superior wet adhesive properties of marine mussels, researchers have used mussel‐inspired chemistry to create mussel‐mimetic injectable polysaccharide‐based hydrogels that are simple to operate, controllable in shape, and highly adhesive, and have significantly extended their applications such as tissue adhesives, delivery vehicles, tissue engineering scaffolds, and wearable sensors. However, there are few comprehensive reviews on polysaccharide‐based hydrogels with both mussel‐mimetic adhesion and injectability, and few critical analyses of these hydrogels' preparation methods and applications. This review fills this gap and systematically summarizes the preparation strategies for novel mussel‐mimetic injectable polysaccharide‐based hydrogels, including modifying polysaccharides with catechol‐ or pyrogallol‐containing small molecules and leveraging different interactions between catechol‐/pyrogallol‐modified polysaccharides and other substances to form crosslinked hydrogels. Furthermore, recent biomedical applications of injectable catechol‐/pyrogallol‐modified polysaccharide‐based hydrogels are discussed, and their future challenges and research trends are proposed.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"7 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0