BMEMat最新文献 - Book学术

Nanomedicine hitchhiking on bacteria for treating tumors (4/2024)

BMEMat Pub Date : 2024-12-25 DOI: 10.1002/bmm2.12131

Shujing Zheng, Xingwei Li, Shutao Guo

引用次数: 0

A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (4/2024)

BMEMat Pub Date : 2024-12-25 DOI: 10.1002/bmm2.12132

He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang

引用次数: 0

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair (3/2024) 用于动态组织修复的扩散诱导相分离三维打印支架 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12119

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

引用次数: 0

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024) 基于感染反应多糖的载药纳米组件，用于抗耐药细菌肺部感染的双模式治疗 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12120

Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu

引用次数: 0

Is deep brain imaging on the brink of transformation with a bioluminescence molecule? 利用生物发光分子进行脑深部成像是否即将实现变革？

BMEMat Pub Date : 2024-08-16 DOI: 10.1002/bmm2.12115

Shumao Xu, Farid Manshaii, Jun Chen

引用次数: 0

Reverse thinking: Tumor nutritional therapy 逆向思维肿瘤营养疗法

BMEMat Pub Date : 2024-07-20 DOI: 10.1002/bmm2.12114

Binbin Ding, Ping'an Ma, Abdulaziz A. Al Kheraif, Jun Lin

引用次数: 0

Nano/genetically engineered cells for immunotherapy 用于免疫疗法的纳米/基因工程细胞

BMEMat Pub Date : 2024-07-17 DOI: 10.1002/bmm2.12112

Jingrui Shen, Yang Zhou, Lichen Yin

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引用次数: 0

Tissue clearing and its application in dental research 组织清理及其在牙科研究中的应用

BMEMat Pub Date : 2024-07-15 DOI: 10.1002/bmm2.12113

Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang

{"title":"Tissue clearing and its application in dental research","authors":"Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang","doi":"10.1002/bmm2.12113","DOIUrl":"https://doi.org/10.1002/bmm2.12113","url":null,"abstract":"For both animal and human tissues, translucence is an intrinsic property that gives them a milky appearance. This optical property arises due to the combined effects of light absorption and scattering and becomes the main impediment of deep imaging. To overcome these obstacles, the tissue‐clearing technique has experienced a resurgence over the past century and evolved from its initial use in neuroscience to encompass various samples due to the emergence of various clearing methods. Notably, these techniques unveil both macroscopic and microscopic details, offering valuable insights into tissue structures. In particular, the oral cavity is structured with both soft and hard tissues at the macroscopic level and is rich in neurovascular networks microscopically, providing a suitable application environment for tissue‐clearing techniques. Currently, tissue‐clearing techniques have provided a powerful tool for research on the dental pulp neurovascular system, oral tissue regeneration, dental implants, and maxillofacial surgical treatments. Hence, this review aims to give a general introduction to tissue‐clearing techniques and focus on their remarkable applications in dental research. At last, we will discuss the integration of tissue‐clearing methods with other techniques such as labeling and microscopy, hoping to offer valuable insights for the development of tissue‐clearing techniques in both bioscience and materials science.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"15 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine hitchhiking on bacteria for treating tumors

BMEMat Pub Date : 2024-06-25 DOI: 10.1002/bmm2.12110

Shujing Zheng, Xingwei Li, Shutao Guo

{"title":"Nanomedicine hitchhiking on bacteria for treating tumors","authors":"Shujing Zheng, Xingwei Li, Shutao Guo","doi":"10.1002/bmm2.12110","DOIUrl":"https://doi.org/10.1002/bmm2.12110","url":null,"abstract":"Nanomedicine has shown promising therapeutic potential in cancer treatment, with clinically approved formulations such as Doxil® and Abraxane® already providing tangible benefits to patients. However, challenges such as low targeting efficiency and poor tumor penetration limit its application. Bacteria have emerged as promising drug delivery carriers due to their capacity for autonomous navigation and deep penetration into hypoxic tumor parenchyma. Therefore, utilizing bacteria as carriers for nanomedicine can partially overcome the limitations of anti-tumor nanomedicine. Moreover, some bacteria, like Salmonella typhimurium and Escherichia coli, exhibit immunostimulatory and oncolytic effects and can synergistically enhance the anti-tumor effects of nanomedicine. This article summarizes common types of bacteria and nanomedicines and their respective advantages and challenges in cancer treatment. It elaborates on various strategies for combining bacteria and nanomedicine under different administration routes, outlining the clinical progress and challenges of bacterial anti-tumor therapy and outlooking for future applications of utilizing bacteria as carriers for nanomedicine in cancer treatment.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair 用于动态组织修复的扩散诱导相分离三维打印支架

BMEMat Pub Date : 2024-06-12 DOI: 10.1002/bmm2.12108

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

{"title":"Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair","authors":"Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi","doi":"10.1002/bmm2.12108","DOIUrl":"10.1002/bmm2.12108","url":null,"abstract":"Many hydrogen-bonded cross-linked hydrogels possess unique properties, but their limited processability hinders their potential applications. By incorporating a hydrogen bond dissociator (HBD) into these hydrogels, we developed injectable 3D printing inks termed diffusion-induced phase separation (DIPS) 3D printing inks. Upon extrusion into water and subsequent diffusion of HBD, these ink cure rapidly. The DIPS-printed scaffold retained most of the original hydrogel properties due to the regeneration of hydrogen bonds. Additionally, the reversible nature of hydrogen bonds provides DIPS 3D-printed scaffolds with exceptional recycling and reprinting capabilities, resulting in a reduction in the waste of valuable raw ink materials or additives. Postprocessing introduces new crosslinking methods that modulate the mechanical properties and degradation characteristics of DIPS scaffolds over a broad range. Based on its suitable mechanical properties and bioactivity, we successfully repaired and functionally reconstructed a complex defect in penile erectile tissue using the DIPS scaffold in a rabbit model. In summary, this approach is relevant for various hydrogen-bonded cross-linked hydrogels that offer mild printing conditions and enable the incorporation of bioactive agents. They can be used as scaffolds for dynamic tissue reconstruction, wearable devices, or soft robots.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0