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Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects (2/2025) 用于增强x射线引发的癌症治疗的纳米材料：进展和前景（2/2025）
BMEMat Pub Date : 2025-06-28 DOI: 10.1002/bmm2.70023
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan
{"title":"Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects (2/2025)","authors":"Yuanchun Chen,&nbsp;Shijie Shangguan,&nbsp;Zhongyu Lin,&nbsp;Xuemei Zeng,&nbsp;Siew Yin Chan,&nbsp;Xian Qin,&nbsp;Shuangqian Yan","doi":"10.1002/bmm2.70023","DOIUrl":"https://doi.org/10.1002/bmm2.70023","url":null,"abstract":"<p>In article 10.1002/bmm2.12122, Yuanchun Chen and colleagues review recent progress in nanomaterials for X-ray-triggered cancer therapy. They emphasize the advantages of these systems, including targeted delivery, reduced side effects, and improved therapeutic efficacy. The article also discusses key challenges such as biosafety, limited clinical translation, and activation precision. By exploring future directions and potential solutions, this review provides valuable guidance for researchers and clinicians aiming to develop effective, X-ray-responsive strategies for precise and minimally invasive cancer treatment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver organoids: From 3D printing to biomedical applications (2/2025) 类肝器官：从3D打印到生物医学应用（2/2025）
BMEMat Pub Date : 2025-06-28 DOI: 10.1002/bmm2.70024
Ying Shi, Xin Han, Zheng Zhang, Jiangtao Xu, Guozhen Liu
{"title":"Liver organoids: From 3D printing to biomedical applications (2/2025)","authors":"Ying Shi,&nbsp;Xin Han,&nbsp;Zheng Zhang,&nbsp;Jiangtao Xu,&nbsp;Guozhen Liu","doi":"10.1002/bmm2.70024","DOIUrl":"https://doi.org/10.1002/bmm2.70024","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12129, Ying Shi, Xin Han, and colleagues comprehensively review advances in liver organoid culture techniques, including 3D printing and organ-on-chip systems. They highlight current and future applications while addressing key challenges and future perspectives to drive further progress in this field.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances of nanomaterials in imaging liver fibrosis (2/2025) 纳米材料在肝纤维化成像中的最新进展（2/2025）
BMEMat Pub Date : 2025-06-28 DOI: 10.1002/bmm2.70022
Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun
{"title":"Recent advances of nanomaterials in imaging liver fibrosis (2/2025)","authors":"Jin Cui,&nbsp;Shuxuan Zhang,&nbsp;Xueli Xu,&nbsp;Ke Ren,&nbsp;Mengzhen Dong,&nbsp;Zhaokun Nie,&nbsp;Yang Xu,&nbsp;Xiaohui Dai,&nbsp;Peng Xu,&nbsp;Shuo Sun,&nbsp;Xinya Zhao,&nbsp;Xiao Sun","doi":"10.1002/bmm2.70022","DOIUrl":"https://doi.org/10.1002/bmm2.70022","url":null,"abstract":"<p>Early diagnosis and accurate staging of liver fibrosis has emerged as a major focus and significant challenge in clinical research, attracting considerable scientific attention. In the review (DOI: 10.1002/bmm2.12123), Jin Cui, Xinya Zhao, and Xiao Sun systematically summarize current applications of various nanomaterials in liver fibrosis imaging, particularly utilization in targeting hepatic stellate cells and extracellular matrix components. Their work provides valuable insights and a robust reference framework for future developments in nanomaterials-based strategies for early detection and timely therapeutic intervention of liver fibrosis.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring (1/2025) 汗液驱动，皮肤粘附式多模态传感器，用于长期和实时汗液监测（1/2025）
BMEMat Pub Date : 2025-03-31 DOI: 10.1002/bmm2.70007
Xinxin He, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yuyang Zeng, Jialin Li, Chun Ki Yiu, Yawen Yang, Jingkun Zhou, Guoqiang Xu, Jiachen Wang, Jian Li, Zitong Xu, Zhenlin Chen, Yiming Liu, Yuyu Gao, Binbin Zhang, Guangyao Zhao, Zhan Gao, Pengcheng Wu, Rui Shi, Yuze Qiu, Hehua Zhang, Lung Chow, Denglin Ye, Ya Huang, Xinge Yu
{"title":"Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring (1/2025)","authors":"Xinxin He,&nbsp;Zhiyuan Li,&nbsp;Xingcan Huang,&nbsp;Qiang Zhang,&nbsp;Yuyang Zeng,&nbsp;Jialin Li,&nbsp;Chun Ki Yiu,&nbsp;Yawen Yang,&nbsp;Jingkun Zhou,&nbsp;Guoqiang Xu,&nbsp;Jiachen Wang,&nbsp;Jian Li,&nbsp;Zitong Xu,&nbsp;Zhenlin Chen,&nbsp;Yiming Liu,&nbsp;Yuyu Gao,&nbsp;Binbin Zhang,&nbsp;Guangyao Zhao,&nbsp;Zhan Gao,&nbsp;Pengcheng Wu,&nbsp;Rui Shi,&nbsp;Yuze Qiu,&nbsp;Hehua Zhang,&nbsp;Lung Chow,&nbsp;Denglin Ye,&nbsp;Ya Huang,&nbsp;Xinge Yu","doi":"10.1002/bmm2.70007","DOIUrl":"https://doi.org/10.1002/bmm2.70007","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12124, Xinxin He, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yuyang Zeng and their co-workers developed a novel multimodal sweat monitoring device, which operates on a sweat-activated battery, can continuously and real-time monitor sweat for pH values, glucose concentration, and chloride ion levels. It seamlessly integrates colorimetric and electrochemical sensors, storing and transmitting data wirelessly via NFC. This enables users to access and analyze health data through their smartphones, enhancing the precision and convenience of long-term health monitoring. The research also explores advancements in sensor adhesion and stability, crucial for improving accuracy and wearer comfort, and discusses the ongoing challenges and future prospects in the field of personalized health monitoring.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy (1/2025) 自动代谢调节剂用于糖酵解干预诱导级联癌症治疗（1/2025）
BMEMat Pub Date : 2025-03-31 DOI: 10.1002/bmm2.70006
Jiao Zheng, Jian Zhang, Tian Zhang, Yongcun Yan, Sai Bi
{"title":"Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy (1/2025)","authors":"Jiao Zheng,&nbsp;Jian Zhang,&nbsp;Tian Zhang,&nbsp;Yongcun Yan,&nbsp;Sai Bi","doi":"10.1002/bmm2.70006","DOIUrl":"https://doi.org/10.1002/bmm2.70006","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12125, Jiao Zheng, Jian Zhang and their co-workers developed an automatic metabolism modulator (auto-MMOD) to intervene in the mitochondrial glycolysis process for cascade antitumor therapy. In the engineered auto-MMOD, the co-encapsulated glucose oxidase (GOx) and DNA-silver nanoclusters (DNA-AgNCs) successfully activates the glycolytic intervention-induced release of Ag+, thereby enhancing tumor inhibition and providing the valuable insight into a biological metabolism-mediated antitumor strategy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing next-generation immune cell therapies with nanomaterials 利用纳米材料设计下一代免疫细胞疗法
BMEMat Pub Date : 2025-03-20 DOI: 10.1002/bmm2.70003
Kangfu Chen, Wenhan Wang, Zongjie Wang
{"title":"Designing next-generation immune cell therapies with nanomaterials","authors":"Kangfu Chen,&nbsp;Wenhan Wang,&nbsp;Zongjie Wang","doi":"10.1002/bmm2.70003","DOIUrl":"https://doi.org/10.1002/bmm2.70003","url":null,"abstract":"<p>Immune Cellular Therapies (ICT) have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors. Despite these successes, ICT faces significant challenges, including tumor accessibility, lengthy manufacturing turnaround, and limited long-term effectiveness. Recent advancements in nanomaterials, particularly nanoparticles, have offered promising solutions to these issues. This perspective introduces the current ICT manufacturing pipeline with a focus on solid tumors and showcases recent nanomaterial-mediated practices to enhance ICT. These efforts include the use of cell-targeting magnetic nanoparticles for non-invasive target identification, lipid nanoparticles for in vivo immune cell stimulation, as well as nanoparticle-mediated gene editing and cytokine delivery to enhance immune cell fitness. By better integrating nanoparticles into the design and manufacturing pipelines, we envision that the next generation of ICT could be faster, more efficient, and capable of targeting a broad spectrum of cancers and inflammatory diseases.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D-cultured BMSC exosomes improve cerebral ischemia/reperfusion injury-induced neuronal apoptosis by regulating the microglia polarization 3d培养BMSC外泌体通过调节小胶质细胞极化改善脑缺血再灌注损伤诱导的神经元凋亡
BMEMat Pub Date : 2025-03-05 DOI: 10.1002/bmm2.70000
Yuming Li, Hao Shang, Qiong Zhang, Xianyong Yin, Zihao Liu, Yuqing Fang, Kyubae Lee, Huayang Zhao, Zhihai Wang, Hongbo Zhao, Xiaofeng Wang, Shengjie Li, Shan Wang, Tao Xin
{"title":"3D-cultured BMSC exosomes improve cerebral ischemia/reperfusion injury-induced neuronal apoptosis by regulating the microglia polarization","authors":"Yuming Li,&nbsp;Hao Shang,&nbsp;Qiong Zhang,&nbsp;Xianyong Yin,&nbsp;Zihao Liu,&nbsp;Yuqing Fang,&nbsp;Kyubae Lee,&nbsp;Huayang Zhao,&nbsp;Zhihai Wang,&nbsp;Hongbo Zhao,&nbsp;Xiaofeng Wang,&nbsp;Shengjie Li,&nbsp;Shan Wang,&nbsp;Tao Xin","doi":"10.1002/bmm2.70000","DOIUrl":"https://doi.org/10.1002/bmm2.70000","url":null,"abstract":"<p>Microglial activation is a key driver of neuroinflammation following cerebral ischemic reperfusion injury (CIRI). Exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) can regulate microglia, causing a transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, thereby reducing neuronal apoptosis in post-reperfusion injuries. However, the generation of superior-quality exosomes remains a significant hurdle in this field. We performed three-dimensional (3D) cultivation of BMSCs using a gelatin methacryloyl (GelMA) hydrogel and collected the released exosomes. We conducted experiments using lipopolysaccharide (LPS)-induced BV2 cells, oxygen-glucose deprivation/reoxygenation (OGD/R)- induced HT22 cells, and CIRI mice to verify the effects of 3D-cultured exosomes in regulating microglial activation and alleviating neuronal apoptosis. Based on the cellular and animal experiments, we successfully demonstrated the remarkable efficacy of exosomes derived from 3D-cultured BMSC using a GelMA hydrogel in the context of CIRI. These exosomes effectively mitigated the conversion of microglia to the inflammatory phenotype and facilitated their transition to the anti-inflammatory phenotype, thereby reducing aseptic inflammatory reactions and neuronal apoptosis. This study demonstrated the effectiveness of GelMA-based 3D-cultured exosomes in treating CIRI and introduced innovative concepts and opportunities for addressing this condition with clinical applications.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic T-cell and local macrophage interactions mediate granule size-dependent biological hydroxyapatite foreign body reaction 全身t细胞和局部巨噬细胞相互作用介导颗粒大小依赖性生物羟基磷灰石异物反应
BMEMat Pub Date : 2025-01-09 DOI: 10.1002/bmm2.12133
Yixiong Lin, Yang Zou, Jieting Yang, Zongpu Han, Xinyu Guo, Xiaomeng Gao, Jieyun Xu, Zhuohong Gong, Ruizhi Li, Zhipeng Li, Baoxin Huang, Yin Xiao, Feilong Deng, Zetao Chen
{"title":"Systemic T-cell and local macrophage interactions mediate granule size-dependent biological hydroxyapatite foreign body reaction","authors":"Yixiong Lin,&nbsp;Yang Zou,&nbsp;Jieting Yang,&nbsp;Zongpu Han,&nbsp;Xinyu Guo,&nbsp;Xiaomeng Gao,&nbsp;Jieyun Xu,&nbsp;Zhuohong Gong,&nbsp;Ruizhi Li,&nbsp;Zhipeng Li,&nbsp;Baoxin Huang,&nbsp;Yin Xiao,&nbsp;Feilong Deng,&nbsp;Zetao Chen","doi":"10.1002/bmm2.12133","DOIUrl":"https://doi.org/10.1002/bmm2.12133","url":null,"abstract":"<p>Biological hydroxyapatite (BHA) has been widely used in alveolar bone augmentation, while unfavorable outcomes can still be encountered. Among several reasons, we noticed a chaotic granule size application issue. The principle behind the choice of proper granule size mainly lies in the fitness of defect shape and size. However, granule size has been shown to elicit significant biological effects, with the underlying mechanisms still unknown. BHA granules of five different sizes were first prepared and characterized to investigate their biological effects. We found that the biomimetic porous structure of BHA gradually disappeared with decreasing size, affecting the structure of the blood clot fibrin network, leading to different local immune microenvironments and foreign body reactions (FBRs). Among them, &lt;0.2 mm BHA granules completely lost their biomimetic porous structure and their fibrin network was loosened with strong immune response and strongest FBR. We found Gata3 (+)/Nfat3 (+) Th2 cells were recruited from activated systemic immune organs, inducing CD206 (+)/CD163 (low) M2 macrophages through direct contact with Ptprc-Mrc1, thereby promoting their fusion to form foreign body giant cells leading to strong FBR. This study expanded the understanding of the size effect of BHA granules from a biological perspective and unveiled the mechanisms of systemic immune towards BHA mediated FBR, providing regulatory targets to improve bone regeneration outcomes.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine hitchhiking on bacteria for treating tumors (4/2024) 搭载细菌的纳米医学治疗肿瘤（4/2024）
BMEMat Pub Date : 2024-12-25 DOI: 10.1002/bmm2.12131
Shujing Zheng, Xingwei Li, Shutao Guo
{"title":"Nanomedicine hitchhiking on bacteria for treating tumors (4/2024)","authors":"Shujing Zheng,&nbsp;Xingwei Li,&nbsp;Shutao Guo","doi":"10.1002/bmm2.12131","DOIUrl":"https://doi.org/10.1002/bmm2.12131","url":null,"abstract":"<p>Taking advantage of autonomous navigation and deep penetration capabilities of bacteria, the use of bacteria as carriers for nanomedicine has attracted significant attention. In the review (DOI: 10.1002/bmm2.12110), Shujing Zheng, Xingwei Li, and Shutao Guo have systematically summarized current strategies for integrating bacteria and nanomedicines through different administration routes, highlighting both the clinical progress and the challenges faced in bacterial-based anti-tumor therapies. They have provided a perspective on the future development of nanomedicine hitchhiking on bacteria for cancer treatment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (4/2024) 甲氨蝶呤和雷公藤红素的仿生触发释放胶束制剂控制胶原诱导的小鼠关节炎（4/2024）
BMEMat Pub Date : 2024-12-25 DOI: 10.1002/bmm2.12132
He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang
{"title":"A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (4/2024)","authors":"He Ren,&nbsp;Zewen Wu,&nbsp;Jingxuan Li,&nbsp;Nan Zhang,&nbsp;Coo Yee Nah,&nbsp;Jiexin Li,&nbsp;Jingyu Zhang,&nbsp;Jonathan F. Lovell,&nbsp;Liyun Zhang,&nbsp;Yumiao Zhang","doi":"10.1002/bmm2.12132","DOIUrl":"https://doi.org/10.1002/bmm2.12132","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12104, He Ren, Zewen Wu, Liyun Zhang, Yumiao Zhang and their co-authors designed an antirheumatic nanoparticle termed CeViM-micelle@B. A methotrexate-conjugated Pluronic F127 micelle was developed to encapsulate anti-inflammatory agent Celastrol (Cel) and the stabilizer Vitamin K (VK), which was further coated by B-cell membrane. The use of CeViM-micelle@B significantly increased drug accumulation at pathological synovial joints, potently inhibited immune cell activation, and effectively prevented erosion of bone and cartilage. This new nanoplatform holds potential for the next-generation targeted rheumatoid arthritis therapy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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