Deciphering the skeletal interoceptive circuitry to control bone homeostasis (3/2025)

Abstract

This article, numbered 10.1002/bmm2.12138, introduces the skeletal interoceptive circuitry. It covers the ascending signals from bone tissues to the brain through sensory nerves (sensors), the central neural circuits that integrate the information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors). A better understanding of this circuitry will inform the development of novel therapies and biomaterials for the management of challenging bone-related disorders.