{"title":"破解骨骼内感受回路控制骨骼稳态（3/2025）","authors":"Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai-Kwok Yeung, Wei Qiao","doi":"10.1002/bmm2.70036","DOIUrl":null,"url":null,"abstract":"<p>This article, numbered 10.1002/bmm2.12138, introduces the skeletal interoceptive circuitry. It covers the ascending signals from bone tissues to the brain through sensory nerves (sensors), the central neural circuits that integrate the information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors). A better understanding of this circuitry will inform the development of novel therapies and biomaterials for the management of challenging bone-related disorders.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70036","citationCount":"0","resultStr":"{\"title\":\"Deciphering the skeletal interoceptive circuitry to control bone homeostasis (3/2025)\",\"authors\":\"Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai-Kwok Yeung, Wei Qiao\",\"doi\":\"10.1002/bmm2.70036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This article, numbered 10.1002/bmm2.12138, introduces the skeletal interoceptive circuitry. It covers the ascending signals from bone tissues to the brain through sensory nerves (sensors), the central neural circuits that integrate the information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors). A better understanding of this circuitry will inform the development of novel therapies and biomaterials for the management of challenging bone-related disorders.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":100191,\"journal\":{\"name\":\"BMEMat\",\"volume\":\"3 3\",\"pages\":\"\"},\"PeriodicalIF\":15.5000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70036\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMEMat\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bmm2.70036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMEMat","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bmm2.70036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Deciphering the skeletal interoceptive circuitry to control bone homeostasis (3/2025)
This article, numbered 10.1002/bmm2.12138, introduces the skeletal interoceptive circuitry. It covers the ascending signals from bone tissues to the brain through sensory nerves (sensors), the central neural circuits that integrate the information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors). A better understanding of this circuitry will inform the development of novel therapies and biomaterials for the management of challenging bone-related disorders.
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