{"title":"揭示癌症细胞衰老的复杂性：从机制到治疗机会（3/2025）","authors":"Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu","doi":"10.1002/bmm2.70037","DOIUrl":null,"url":null,"abstract":"<p>In this article number 10.1002/bmm2.12137, Shanqiang Qu, Guanglong Huang, and co-authors delves into the paradoxical roles of cellular senescence in cancer biology, bridging mechanistic insights to therapeutic innovation. The work systematically unpacks senescence-inducing stimuli, regulatory pathways, and the dual-edged biological consequences of the senescence-associated secretory phenotype (SASP). Furthermore, it recapitulates advances in senescence-associated biomarkers and evaluates the \"one-two punch\" therapeutic paradigm.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70037","citationCount":"0","resultStr":"{\"title\":\"Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities (3/2025)\",\"authors\":\"Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu\",\"doi\":\"10.1002/bmm2.70037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this article number 10.1002/bmm2.12137, Shanqiang Qu, Guanglong Huang, and co-authors delves into the paradoxical roles of cellular senescence in cancer biology, bridging mechanistic insights to therapeutic innovation. The work systematically unpacks senescence-inducing stimuli, regulatory pathways, and the dual-edged biological consequences of the senescence-associated secretory phenotype (SASP). Furthermore, it recapitulates advances in senescence-associated biomarkers and evaluates the \\\"one-two punch\\\" therapeutic paradigm.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":100191,\"journal\":{\"name\":\"BMEMat\",\"volume\":\"3 3\",\"pages\":\"\"},\"PeriodicalIF\":15.5000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70037\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMEMat\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bmm2.70037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMEMat","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bmm2.70037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities (3/2025)
In this article number 10.1002/bmm2.12137, Shanqiang Qu, Guanglong Huang, and co-authors delves into the paradoxical roles of cellular senescence in cancer biology, bridging mechanistic insights to therapeutic innovation. The work systematically unpacks senescence-inducing stimuli, regulatory pathways, and the dual-edged biological consequences of the senescence-associated secretory phenotype (SASP). Furthermore, it recapitulates advances in senescence-associated biomarkers and evaluates the "one-two punch" therapeutic paradigm.
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