BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12104

He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang

{"title":"A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice","authors":"He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang","doi":"10.1002/bmm2.12104","DOIUrl":"10.1002/bmm2.12104","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co-loading the anti-inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)-conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)-micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front-line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM-micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro-inflammatory responses. B cell membrane coating enhanced accumulation of CeViM-micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen-induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next-generation targeted RA treatment.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges 牙科和骨科钛植入物的混合涂层：当前的进展与挑战

BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12105

Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Zhou Ye

{"title":"Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges","authors":"Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Zhou Ye","doi":"10.1002/bmm2.12105","DOIUrl":"10.1002/bmm2.12105","url":null,"abstract":"Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult-to-treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy (2/2024) 金属配位驱动组装用于肿瘤化疗免疫疗法的干扰素基因激活纳米颗粒 (2/2024)

BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12106

Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui

引用次数: 0

Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines (2/2024) 基于聚合物纳米药物的癌症联合免疫疗法的先进战略 (2/2024)

BMEMat Pub Date : 2024-06-07 DOI: 10.1002/bmm2.12107

Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li, Chao Feng, Lei Wang, Kuikun Yang

引用次数: 0

Mussel-mimetic polysaccharide-based injectable hydrogels for biomedical applications 用于生物医学应用的仿贻贝多糖注射水凝胶

BMEMat Pub Date : 2024-05-24 DOI: 10.1002/bmm2.12089

Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang

{"title":"Mussel-mimetic polysaccharide-based injectable hydrogels for biomedical applications","authors":"Yawen Fan, Lu Zheng, Min Jin, Xiaoyun Li, Zhong Alan Li, Xiaoying Wang","doi":"10.1002/bmm2.12089","DOIUrl":"10.1002/bmm2.12089","url":null,"abstract":"With high biocompatibility and degradability, polysaccharide-based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials are inconvenient to handle with fixed morphology, unable to closely match the wounds, and easy to detach due to insufficient adhesion. Inspired by the superior wet adhesive properties of marine mussels, researchers have used mussel-inspired chemistry to create mussel-mimetic injectable polysaccharide-based hydrogels that are simple to operate, controllable in shape, and highly adhesive, and have significantly extended their applications such as tissue adhesives, delivery vehicles, tissue engineering scaffolds, and wearable sensors. However, there are few comprehensive reviews on polysaccharide-based hydrogels with both mussel-mimetic adhesion and injectability, and few critical analyses of these hydrogels' preparation methods and applications. This review fills this gap and systematically summarizes the preparation strategies for novel mussel-mimetic injectable polysaccharide-based hydrogels, including modifying polysaccharides with catechol- or pyrogallol-containing small molecules and leveraging different interactions between catechol-/pyrogallol-modified polysaccharides and other substances to form crosslinked hydrogels. Furthermore, recent biomedical applications of injectable catechol-/pyrogallol-modified polysaccharide-based hydrogels are discussed, and their future challenges and research trends are proposed.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications 光热镧系纳米材料：从基本原理到治疗应用

BMEMat Pub Date : 2024-05-17 DOI: 10.1002/bmm2.12088

Zhuo Li, Jiacheng Gong, Shan Lu, Xingjun Li, Xiaobo Gu, Jin Xu, Jawairia Umar Khan, Dayong Jin, Xueyuan Chen

{"title":"Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications","authors":"Zhuo Li, Jiacheng Gong, Shan Lu, Xingjun Li, Xiaobo Gu, Jin Xu, Jawairia Umar Khan, Dayong Jin, Xueyuan Chen","doi":"10.1002/bmm2.12088","DOIUrl":"10.1002/bmm2.12088","url":null,"abstract":"Photothermal lanthanide nanomaterials with unique photophysical properties have been innovatively explored for diagnostics and non-invasive therapies, and hold great promise for precision theranostics. In this review, we start from the basic principles of excited-state dynamics and provide a thorough comprehension of the main pathways for photothermal conversion in lanthanide nanocrystals. Aspects influencing the photothermal effect such as lanthanide-doping concentration, particle size, and crystal structure have been fully discussed. Hybrid strategies for the design of efficient lanthanide-based photothermal agents, including dye sensitization to break the absorption limit and semiconductor combination to add cross-relaxation pathways, have also been summarized. Furthermore, we highlight the cutting-edge applications of photothermal lanthanide nanoplatforms with optical diagnosis and temperature feedback in photothermia-associated theranostics. Lastly, the current challenges and future eﬀorts for clinical applications are proposed. This review is expected to offer a better understanding of photothermal mechanisms and inspire efforts for designing versatile lanthanide theranostic nanoplatforms.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent textiles make life wirelessly energetic by coupling radiation energy and human 智能纺织品通过将辐射能量与人类生活相结合，使生活充满无线能量

BMEMat Pub Date : 2024-05-16 DOI: 10.1002/bmm2.12090

Dan Zhou, Zhenfang Zhang, Yitong Li, Tianyi Ma, Haijun He, Haoxuan Li

引用次数: 0

Thickening tissue by thinning electrospun scaffolds for skeletal muscle tissue engineering 通过减薄电纺支架增厚组织，用于骨骼肌组织工程

BMEMat Pub Date : 2024-05-15 DOI: 10.1002/bmm2.12084

Shuo Wang, Xinhuan Wang, Minxuan Jia, Wenli Liu, Qi Gu

{"title":"Thickening tissue by thinning electrospun scaffolds for skeletal muscle tissue engineering","authors":"Shuo Wang, Xinhuan Wang, Minxuan Jia, Wenli Liu, Qi Gu","doi":"10.1002/bmm2.12084","DOIUrl":"10.1002/bmm2.12084","url":null,"abstract":"Electrospun scaffolds with aligned fiber orientation are widely used in tissue engineering, such as muscle, heart, nerve, tendon, and cartilage, due to their ability to guide cell morphology and induce cellular functions. However, the dense fibrous structure of the scaffolds poses a critical obstacle to engineering highly cellular and thick 3D tissues, as it prevents cell infiltration. While many techniques have been developed to increase the pore size of electrospun scaffolds and improve cell infiltration/migration, it often leads to a decrease in direct cell-cell contact, compromising cell differentiation and tissue maturation. This study presents an alternative approach by reducing the thickness of scaffolds to the cellular scale and stacking or rolling the cell-scaffold complex into 3D constructs. We devise a series of novel tools to fabricate, characterize, and manipulate ultra-thin electrospun scaffolds, which demonstrate high reproducibility, resolution, and cellularity. Our study provides a solution to the cell infiltration issue in muscle tissue engineering and is highly versatile, and can be applied to various fields that require structures with high-resolution gradients in a layered pattern or complex spatial distribution in a rolled pattern.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Ferritin-based drug delivery system for tumor therapy” 更正 "基于铁蛋白的肿瘤治疗药物输送系统"

BMEMat Pub Date : 2024-05-14 DOI: 10.1002/bmm2.12092

引用次数: 0

Correction to “Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases” 对 "用于预防和治疗心脏病的三电纳米发电机和压电纳米发电机 "的更正

BMEMat Pub Date : 2024-05-14 DOI: 10.1002/bmm2.12094

引用次数: 0

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