BMEMat最新文献

{"title":"Liver organoids: From 3D printing to biomedical applications","authors":"Ying Shi,&nbsp;Xin Han,&nbsp;Zheng Zhang,&nbsp;Jiangtao Xu,&nbsp;Guozhen Liu","doi":"10.1002/bmm2.12129","DOIUrl":"https://doi.org/10.1002/bmm2.12129","url":null,"abstract":"<p>The liver is an immune organ, especially an immune tolerance organ. The critical shortage of donor organs and disease models for the treatment of end-stage liver failure underscores the urgent need for the generation of liver organoids from human induced pluripotent stem cells (iPSCs). Notably, significant advancements have been made in the study of liver organoids over the past decade. The construction of liver organoids has transitioned from single cell type to multicellular models, and from two-dimensional to three-dimensional cultures. Here we provide the progress surrounding the different liver organoids culture techniques from 3D printing to organ-on-chip, as well as focuses on the present and future applications of liver organoids, and then to present challenges and perspectives ahead for further advancement.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple approach to biophysical profiling of blood cells in extranodal NK/T cell lymphoma patients using deep learning-integrated image cytometry","authors":"Seongcheol Park,&nbsp;Sang Eun Yoon,&nbsp;Youngho Song,&nbsp;Changyu Tian,&nbsp;Changi Baek,&nbsp;Hyunji Cho,&nbsp;Won Seog Kim,&nbsp;Seok Jin Kim,&nbsp;Soo-Yeon Cho","doi":"10.1002/bmm2.12128","DOIUrl":"https://doi.org/10.1002/bmm2.12128","url":null,"abstract":"<p>Extranodal NK/T cell lymphoma (ENKTL) poses significant challenges in efficient treatment processes due to its aggressive nature and high recurrence rates. There is a critical need to develop a robust statistical model to predict treatment efficacy by dynamically quantifying biomarkers tailored to various stages of lymphoma. Recent analytics such as sequencing and microbiome tests have only been utilized to understand lymphoma progression and treatment response in clinical settings. However, these methods are limited by their quantitative analysis capabilities, long turnaround times, and lack of single-cell resolution, which are essential for understanding the heterogeneous nature of lymphoma. In this study, we developed a deep learning-enhanced image cytometry (DLIC) to investigate biophysical heterogeneities in peripheral blood mononuclear cells (PBMCs) from newly diagnosed (ND) ENKTL patients. We established a substantial cohort of 23 ND ENKTL patients, categorizing them into interim of treatment (<i>n</i> = 21) and end of treatment (<i>n</i> = 19) stages along their serial treatment timelines. Using a basic optical microscope and a commercial microchip, we analyzed over 270,000 single PBMCs in high-throughput, profiling their size, eccentricity, and refractive index in a completely label-free and quantified manner through AI-based nanophotonic computation. We observed distinct heterogeneity variations in these three biophysical indicators across treatment stages and relapse statuses, revealing solid mechanistic correlations among the phenotypes. We established a three-dimensional single-cell distribution map for ENKTL patients and created a standard for quantifying the change in occupational volume. Leveraging this extensive database, DLIC offers on-site analytics in clinical settings, facilitating treatment assessment and prognosis prediction through label-free biophysical analysis of patient PBMCs, extracted directly without additional sample preparation.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjugated polymers as photocatalysts for hydrogen therapy","authors":"Feixue Mi,&nbsp;Ningjing Zhao,&nbsp;Lingyue Jin,&nbsp;Ziyi Zhang,&nbsp;Xinyu Wang,&nbsp;Xiaofeng Fang,&nbsp;Wenting Li,&nbsp;Zhao Liu,&nbsp;Peng Shu,&nbsp;Xuanjun Zhang,&nbsp;Changfeng Wu","doi":"10.1002/bmm2.12126","DOIUrl":"https://doi.org/10.1002/bmm2.12126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Hydrogen as a therapeutic agent has attracted a great deal of attention because of its superior therapeutic outcome on many diseases, including inflammatory injury, tumors, metabolic disorders, and neurological diseases. Photocatalytic hydrogen evolution has emerged as a promising strategy for hydrogen production and delivery. This review article presents the recent developments in the design and synthesis of conjugated polymer materials, including linear polymers and crosslinked conjugated materials, for photocatalytic hydrogen evolution. Particularly, we focus this review on the development of conjugated polymers as photocatalysts and the resulting hydrogen therapy in the fields of anti-inflammatory, free radical scavenging, and cancer treatment. Finally, this article discusses the future research and perspective of conjugated polymer materials for hydrogen evolution and the potential clinical applications of hydrogen as a therapeutic agent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of extracellular RNA and its derived biomaterials in disease management","authors":"Yu Wei,&nbsp;Zhangyi Wang,&nbsp;Zixuan Qin,&nbsp;Qianqian Wan,&nbsp;Yutao Li,&nbsp;Franklin R. Tay,&nbsp;Chenyu Wang,&nbsp;Tong Zhang,&nbsp;Lina Niu","doi":"10.1002/bmm2.12127","DOIUrl":"https://doi.org/10.1002/bmm2.12127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used as indicators of disease status or the physiological health of an organism. A large number of RNA-based biomaterials have been developed by simulating the biological function and structure of natural RNA molecules. The structural programmability of RNA-based biomaterials provides the spur for scientists to pioneer new approaches in disease detection and prevention. Nevertheless, the link between exRNA function and the design of RNA-based biomaterials has not been fully understood. Understanding the biological structure and function of exRNA will contribute to the clinical translation of this novel biotechnology. The present review discusses the research progress associated with exRNA and their derivatives to bridge the gap between natural exRNA and RNA-based biomaterials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects","authors":"Yuanchun Chen,&nbsp;Shijie Shangguan,&nbsp;Zhongyu Lin,&nbsp;Xuemei Zeng,&nbsp;Siew Yin Chan,&nbsp;Xian Qin,&nbsp;Shuangqian Yan","doi":"10.1002/bmm2.12122","DOIUrl":"https://doi.org/10.1002/bmm2.12122","url":null,"abstract":"<p>X-rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X-ray efficacy remains a critical challenge due to issues such as radiation resistance and damage to surrounding health tissues. Recent advancements in nanotechnology have introduced new opportunities and challenges in cancer diagnosis and treatment. This review summarizes the latest progress in nanomaterials for X-ray-triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, metal sulfides, metal fluorides, rare earth oxides, cluster compounds, metal-organic frameworks, and nanohybrids, enhance the effectiveness of X-ray-triggered treatments. Furthermore, we address the current challenges and future prospects of efficient X-ray-triggered cancer therapy, aiming to provide a comprehensive overview for researchers and clinicians in the field.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring","authors":"Xinxin He,&nbsp;Zhiyuan Li,&nbsp;Xingcan Huang,&nbsp;Qiang Zhang,&nbsp;Yuyang Zeng,&nbsp;Jialin Li,&nbsp;Chun Ki Yiu,&nbsp;Yawen Yang,&nbsp;Jingkun Zhou,&nbsp;Guoqiang Xu,&nbsp;Jiachen Wang,&nbsp;Jian Li,&nbsp;Zitong Xu,&nbsp;Zhenlin Chen,&nbsp;Yiming Liu,&nbsp;Yuyu Gao,&nbsp;Binbin Zhang,&nbsp;Guangyao Zhao,&nbsp;Zhan Gao,&nbsp;Pengcheng Wu,&nbsp;Rui Shi,&nbsp;Yuze Qiu,&nbsp;Hehua Zhang,&nbsp;Lung Chow,&nbsp;Denglin Ye,&nbsp;Ya Huang,&nbsp;Xinge Yu","doi":"10.1002/bmm2.12124","DOIUrl":"https://doi.org/10.1002/bmm2.12124","url":null,"abstract":"<p>The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearable devices for physiological and biochemical monitoring, critical issues of power management and device/skin interfacial properties restrict the advancement of personalized healthcare and early disease detection. Here, we report a multimodal sweat monitoring device featuring a real-time display and long-term data analysis based on self-powered format of sweat-activated batteries (SABs). The polyvinyl alcohol-sucrose (PVA-Suc) hydrogel serves as the key component for the SAB, offering not only great long-term adhesive properties for conformable wearability but also significant power generation capabilities. A maximum current density of 44.06 mA cm⁻² and a maximum power density of 21.89 mW cm⁻² can be realized for the hydrogel based SAB. The resulting device integrates an advanced colorimetric and electrochemical sensor array to measure pH levels, glucose concentrations, and chloride ion levels in human sweat, with data wirelessly transmitted by Near Field Communication. The self-powering features and multiple mode sensing function offer sufficient power to support real-time monitoring of metabolic biomarkers in sweat, with the ability to visually observe changes in the colorimetric sensors for long-term data monitoring.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy","authors":"Jiao Zheng,&nbsp;Jian Zhang,&nbsp;Tian Zhang,&nbsp;Yongcun Yan,&nbsp;Sai Bi","doi":"10.1002/bmm2.12125","DOIUrl":"https://doi.org/10.1002/bmm2.12125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Effective intervention in glycolytic metabolism is a promising way to inhibit tumor malignant invasion. However, the inherent hypoxia environment and unitary regulating model subsequently compromise its therapeutic efficacy. Herein, a facile way to design an automatic metabolism modulator (auto-MMOD) is developed by loading glucose oxidase (GOx) and DNA-templated silver nanoclusters (DNA-AgNCs) into a pH-responsive zeolitic imidazolate frameworks-8 (ZIF-8) nanocarrier, which can activate a cascaded metal ion-killing effect during GOx-regulated glycolysis metabolism. When the acidic lysosome microenvironment induces ZIF-8 decomposition, the released GOx can effectively consume glucose and generate H₂O₂, thus inhibiting Adenosine Triphosphate synthesis and accelerating tumor starvation. Moreover, the released Ag⁺ in response to H₂O₂ can disturb bioenergy metabolism to inhibit tumor proliferation, which further enhances the tumor-killing effect in hypoxic microenvironments. This study achieves effective tumor suppression in vitro and in vivo by integrating ion therapy into glycolysis intervention, which establish a promising strategy for nano-theranostics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances of nanomaterials in imaging liver fibrosis","authors":"Jin Cui,&nbsp;Shuxuan Zhang,&nbsp;Xueli Xu,&nbsp;Ke Ren,&nbsp;Mengzhen Dong,&nbsp;Zhaokun Nie,&nbsp;Yang Xu,&nbsp;Xiaohui Dai,&nbsp;Peng Xu,&nbsp;Shuo Sun,&nbsp;Xinya Zhao,&nbsp;Xiao Sun","doi":"10.1002/bmm2.12123","DOIUrl":"https://doi.org/10.1002/bmm2.12123","url":null,"abstract":"<p>Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix. If left untreated, it can progress to cirrhosis, liver failure, and even liver cancer. There is currently no efficient and accurate clinical diagnostic method for early liver fibrosis. Therefore, there is an urgent need to address the challenge of accurate staging and early diagnosis of liver fibrosis in clinical practice. Recently, nanomaterials have demonstrated significant potential for enhancing the diagnosis of liver fibrosis. Nanomaterials possess the ability to precisely identify and target the microenvironment associated with liver fibrosis. By enhancing their enrichment in the target area, nanomaterials can improve imaging contrast of fibrosis lesions in the liver, thereby enabling accurate diagnosis of liver fibrosis. Accordingly, this review delves into the latest research and advancements concerning nanomaterials in liver fibrosis diagnosis.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacrificial strategy towards the formation of vascular-like networks in volumetric tissue constructs","authors":"Christian Buckley,&nbsp;Rana Ibrahim,&nbsp;Felicia Giordano,&nbsp;Nuo Xu,&nbsp;Brandon Sems,&nbsp;Hongjun Wang","doi":"10.1002/bmm2.12118","DOIUrl":"https://doi.org/10.1002/bmm2.12118","url":null,"abstract":"<p>The fields of tissue engineering and regenerative medicine have made astounding progress in recent years, evidenced by cutting-edge 4D printing technologies, precise gene editing tools, and sustained long-term functionality of engineered tissue grafts. Despite these fantastic feats, the clinical success of tissue-engineered constructs so far remains limited to only those relatively simple types of tissues such as thin bilayer skin equivalents or avascular cartilage. On the other hand, volumetric tissues (larger than a few millimeters in all dimensions), which are highly desirable for clinical utility, suffer from poor oxygen supply due to limited dimensional diffusion. Notably, large, complex tissues typically require a vascular network to supply the growing cells with nutrients for metabolic demands to prolong viability and support tissue formation. In recognition, extensive efforts have been made to create vascular-like networks in order to facilitate mass exchange through volumetric scaffolds. This review underlines the urgent need for continued research to create more complex and functional vascular networks, which is crucial for generating viable volumetric tissues, and highlights the recent advances in sacrificial template-enabled formation of vascular-like networks.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning integrated graphene oxide-based diagnostics, drug delivery, analytical approaches to empower cancer diagnosis","authors":"Suparna Das,&nbsp;Hirak Mazumdar,&nbsp;Kamil Reza Khondakar,&nbsp;Ajeet Kaushik","doi":"10.1002/bmm2.12117","DOIUrl":"https://doi.org/10.1002/bmm2.12117","url":null,"abstract":"<p>Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)-based devices with ML techniques. The production techniques and functionalization tactics used to modify the physicochemical characteristics of GO for specific drug delivery are explained at the outset of the investigation. GO is a great option for treating cancer because of its natural biocompatibility and capacity to absorb medicinal chemicals. Then, complicated biological data are analyzed using ML algorithms, which make it possible to identify the best medicine formulations and individualized treatment plans depending on each patient's particular characteristics. The study also looks at optimizing and predicting the interactions between GO carriers and cancer cells using ML. Predictive modeling helps ensure effective payload release and therapeutic efficacy in the design of customized drug delivery systems. Furthermore, tracking treatment outcomes in real time is made possible by ML algorithms, which permit adaptive modifications to therapy regimens. By optimizing medication doses and delivery settings, the combination of ML and GO in cancer therapy not only decreases adverse effects but also enhances treatment accuracy.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}