Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy (1/2025)

BMEMat Pub Date : 2025-03-31 DOI:10.1002/bmm2.70006
Jiao Zheng, Jian Zhang, Tian Zhang, Yongcun Yan, Sai Bi
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Abstract

In this article number 10.1002/bmm2.12125, Jiao Zheng, Jian Zhang and their co-workers developed an automatic metabolism modulator (auto-MMOD) to intervene in the mitochondrial glycolysis process for cascade antitumor therapy. In the engineered auto-MMOD, the co-encapsulated glucose oxidase (GOx) and DNA-silver nanoclusters (DNA-AgNCs) successfully activates the glycolytic intervention-induced release of Ag+, thereby enhancing tumor inhibition and providing the valuable insight into a biological metabolism-mediated antitumor strategy.

Abstract Image

自动代谢调节剂用于糖酵解干预诱导级联癌症治疗(1/2025)
在本文10.1002/bmm2.12125中,郑姣、张健等人开发了一种自动代谢调节剂(auto-MMOD),干预线粒体糖酵解过程,用于级联抗肿瘤治疗。在工程化的auto-MMOD中,共包被的葡萄糖氧化酶(GOx)和dna -银纳米簇(dna - agnc)成功激活糖酵解干预诱导的Ag+释放,从而增强肿瘤抑制作用,并为生物代谢介导的抗肿瘤策略提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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