Jiao Zheng, Jian Zhang, Tian Zhang, Yongcun Yan, Sai Bi
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Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy (1/2025)
In this article number 10.1002/bmm2.12125, Jiao Zheng, Jian Zhang and their co-workers developed an automatic metabolism modulator (auto-MMOD) to intervene in the mitochondrial glycolysis process for cascade antitumor therapy. In the engineered auto-MMOD, the co-encapsulated glucose oxidase (GOx) and DNA-silver nanoclusters (DNA-AgNCs) successfully activates the glycolytic intervention-induced release of Ag+, thereby enhancing tumor inhibition and providing the valuable insight into a biological metabolism-mediated antitumor strategy.
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