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Analgesic nanomedicines for the treatment of chronic pain 用于治疗慢性疼痛的镇痛纳米药物
BMEMat Pub Date : 2023-10-05 DOI: 10.1002/bmm2.12049
Hao Liu, Hongjun Zhuang, Ya Wang, Yuen Yee Cheng, Feixiang Chen, Jian Chen, Xinglei Song, Run Zhang, Yanyan Liu, Wenbo Bu
{"title":"Analgesic nanomedicines for the treatment of chronic pain","authors":"Hao Liu,&nbsp;Hongjun Zhuang,&nbsp;Ya Wang,&nbsp;Yuen Yee Cheng,&nbsp;Feixiang Chen,&nbsp;Jian Chen,&nbsp;Xinglei Song,&nbsp;Run Zhang,&nbsp;Yanyan Liu,&nbsp;Wenbo Bu","doi":"10.1002/bmm2.12049","DOIUrl":"10.1002/bmm2.12049","url":null,"abstract":"<p>Chronic pain is a major cause of suffering that often accompanies diseases and therapies, affecting approximately 20% of individuals at some point in their lives. However, current treatment modalities, such as anesthetic and antipyretic analgesics, have limitations in terms of efficacy and side effects. Nanomedical technology offers a promising avenue to overcome these challenges and introduce new therapeutic mechanisms. This article reviews the recent research on nanomedicine analgesics, integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic pain. Furthermore, it explores potential future strategies using nanomaterials, aiming to provide a roadmap for new analgesic development and improved clinical pain management. By leveraging nanotechnology, these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stretching boundaries in neurophysiological monitoring 拓展神经生理学监测的边界
BMEMat Pub Date : 2023-09-29 DOI: 10.1002/bmm2.12054
Bo Hou, Xiaogang Liu
{"title":"Stretching boundaries in neurophysiological monitoring","authors":"Bo Hou,&nbsp;Xiaogang Liu","doi":"10.1002/bmm2.12054","DOIUrl":"10.1002/bmm2.12054","url":null,"abstract":"<p>The most prevalent among nervous system tumors significantly jeopardize patient health. For nerve integrity preservation after tumor removal, continuous intraoperative neurophysiological monitoring (CINM) is indispensable during microsurgery. The paper highlights the articles about the development of a system that employs soft and stretchable organic electronic materials for CINM. This innovative system harnesses soft and stretchable organic electronic materials and deploys conductive polymer electrodes with low impedance and modulus. These electrodes facilitate uninterrupted near-field action potential recording during surgery, resulting in enhanced signal-to-noise ratios and reduced invasiveness. Additionally, the system's multiplexing capabilities enable precise nerve localization, even in the absence of anatomical landmarks.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform (3/2023) 氧化锌纳米棒阵列通过单细胞微流体平台实时筛选细胞因子对乳腺癌症细胞的抑制作用(3/2023)
BMEMat Pub Date : 2023-09-28 DOI: 10.1002/bmm2.12050
Ping Li, Chao Wang, Jiaoyan Qiu, Fangteng Song, Yuzhen Huang, Yunhong Zhang, Kai Zhang, Hao Ji, Yuanhua Sang, Jonny J. Blaker, Yu Zhang, Lin Han
{"title":"Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform (3/2023)","authors":"Ping Li,&nbsp;Chao Wang,&nbsp;Jiaoyan Qiu,&nbsp;Fangteng Song,&nbsp;Yuzhen Huang,&nbsp;Yunhong Zhang,&nbsp;Kai Zhang,&nbsp;Hao Ji,&nbsp;Yuanhua Sang,&nbsp;Jonny J. Blaker,&nbsp;Yu Zhang,&nbsp;Lin Han","doi":"10.1002/bmm2.12050","DOIUrl":"https://doi.org/10.1002/bmm2.12050","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12040, Ping Li, Chao Wang and their co-workers systematically studied the inhibitory effects of zinc oxide nanorods (ZnO NRs) on breast cancer cells. They found that the ZnO NRs inhibited the migration and growth of cell populations, as well as suppressed the secretion of multiple cytokines through a microfluidic platform. Subsequently, they utilized a single-cell chip to explore the cell heterogeneity before and after the inhibition. Based on the different behaviors exhibited by the cells, they reclassified cell clusters and ultimately discovered that ZnO NRs had a weaker inhibitory effect on highly invasive and metastatic cell populations. This offers a reasonable risk analysis for the potential application of ZnO NRs in cancer therapy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50147072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aptamer-ased Strategies Against SARS-CoV-2 Viruses (3/2023) 针对严重急性呼吸系统综合征冠状病毒2型病毒的基于适体的策略(3/2023)
BMEMat Pub Date : 2023-09-28 DOI: 10.1002/bmm2.12051
Yihao Huang, Ximing Chen, Jialu Zhang, Wenhai Tian, Siwen Liu, Rachel Chun-Yee Tam, Chaoyong Yang, Yanling Song
{"title":"Aptamer-ased Strategies Against SARS-CoV-2 Viruses (3/2023)","authors":"Yihao Huang,&nbsp;Ximing Chen,&nbsp;Jialu Zhang,&nbsp;Wenhai Tian,&nbsp;Siwen Liu,&nbsp;Rachel Chun-Yee Tam,&nbsp;Chaoyong Yang,&nbsp;Yanling Song","doi":"10.1002/bmm2.12051","DOIUrl":"https://doi.org/10.1002/bmm2.12051","url":null,"abstract":"<p>In article number 10.1002/bmm2.12024, Yihao Huang, Ximing Chen, and their co-workers have comprehensively summarized the aptamers against SARS-CoV-2. They have described the aptamer-based diagnostic and therapeutic tools for SARS-CoV-2. In addition, they have discussed the introduction of nanostructures to improve the properties of aptamers and broaden their applications in sensing, therapeutics, mechanistic studies and vaccine design. Finally, they have provided a perspective on the future development of aptamers against SARS-CoV-2 or other virus.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50146886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments 外周神经系统的神经调节:生物电子技术与未来发展
BMEMat Pub Date : 2023-09-26 DOI: 10.1002/bmm2.12048
Hayoung Song, Moohyun Kim, Enji Kim, Jakyoung Lee, Inhea Jeong, Kyeonghee Lim, Seoung Young Ryu, Myoungjae Oh, Younhee Kim, Jang-Ung Park
{"title":"Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments","authors":"Hayoung Song,&nbsp;Moohyun Kim,&nbsp;Enji Kim,&nbsp;Jakyoung Lee,&nbsp;Inhea Jeong,&nbsp;Kyeonghee Lim,&nbsp;Seoung Young Ryu,&nbsp;Myoungjae Oh,&nbsp;Younhee Kim,&nbsp;Jang-Ung Park","doi":"10.1002/bmm2.12048","DOIUrl":"10.1002/bmm2.12048","url":null,"abstract":"<p>The peripheral nervous system (PNS) is a fascinatingly complex and crucial component of the human body, responsible for transmitting vital signals throughout the body's intricate network of nerves. Its efficient functioning is paramount to our health, with any dysfunction often resulting in serious medical conditions, including motor disorders, neurological diseases, and psychiatric disorders. Recent strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health issues. Neuromodulation involves modifying nerve activity using a range of techniques, such as electrical, chemical, optical, and mechanical stimulation. Bioelectronics plays a critical role in this effort, allowing for precise, controlled, and sustained stimulation of the PNS. This paper provides an overview of the PNS, discusses the current state of neuromodulation devices, and presents emerging trends in the field, including advances in wireless power transfer and materials, that are shaping the future of neuromodulation.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy 用于增强癌症催化治疗的多金属基纳米酶的最新进展
BMEMat Pub Date : 2023-09-19 DOI: 10.1002/bmm2.12043
Mingjin Cui, Bo Xu, Lianhui Wang
{"title":"Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy","authors":"Mingjin Cui,&nbsp;Bo Xu,&nbsp;Lianhui Wang","doi":"10.1002/bmm2.12043","DOIUrl":"10.1002/bmm2.12043","url":null,"abstract":"<p>Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing natural enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest and exploration in the utilization of nanozymes for targeted cancer treatment. Recent advancements in interdisciplinary research, nanotechnology, biotechnology, and catalytic technology have led to the emergence of multi-metallic-based nanozymes, which exhibit tremendous potential for further development. This review focuses on investigating the synergistic effects of multi-metallic-based nanozymes, aiming to enhance our understanding of their catalytic activities and facilitate their broader applications. We comprehensively survey the remarkable achievements in the synthesis, catalytic mechanisms, and the latest applications of multi-metallic-based nanozymes in cancer catalytic therapy. Furthermore, we identify the current limitations and prospects of multi-metallic-based nanozymes in the development of new materials and the application of novel technologies, along with the potential challenges associated with catalytic cancer therapy. This review underscores the significance of multi-metallic-based nanozymes and emphasizes the need for continued exploration as well as their potential impact on the development of novel materials and the realization of breakthroughs in catalytic tumor therapy.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135015258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in sensor developments for cell culture monitoring 用于细胞培养监测的传感器开发进展
BMEMat Pub Date : 2023-09-19 DOI: 10.1002/bmm2.12047
Ka Ram Kim, Woon-Hong Yeo
{"title":"Advances in sensor developments for cell culture monitoring","authors":"Ka Ram Kim,&nbsp;Woon-Hong Yeo","doi":"10.1002/bmm2.12047","DOIUrl":"10.1002/bmm2.12047","url":null,"abstract":"<p>Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135107677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Review on carbon dots: Synthesis and application in biology field 碳点综述:合成及在生物领域的应用
BMEMat Pub Date : 2023-09-08 DOI: 10.1002/bmm2.12045
Xueting Li, Lidong Yu, Mingyue He, Ce Chen, Zewen Yu, Shanshan Jiang, Yi Wang, Li Li, Bingsheng Li, Guixue Wang, Aidong Shen, Jianglin Fan
{"title":"Review on carbon dots: Synthesis and application in biology field","authors":"Xueting Li,&nbsp;Lidong Yu,&nbsp;Mingyue He,&nbsp;Ce Chen,&nbsp;Zewen Yu,&nbsp;Shanshan Jiang,&nbsp;Yi Wang,&nbsp;Li Li,&nbsp;Bingsheng Li,&nbsp;Guixue Wang,&nbsp;Aidong Shen,&nbsp;Jianglin Fan","doi":"10.1002/bmm2.12045","DOIUrl":"10.1002/bmm2.12045","url":null,"abstract":"<p>As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size, stable chemical properties, excellent photoluminescence characteristics, but also exhibit good biocompatibility and low toxicity. It has attracted considerable attention in the field of nanotechnology and biological science. CDs contain abundant functional groups on the surface, which not only retain part of the properties of raw materials, but also may have new photoelectric, catalytic, biomedical, and other functions. In this review, we systematically summarize the synthesis methods, modifications, optical properties, and main biological functions of CDs in recent years. The application of functionalized modified CDs in biological detection, biological imaging, photodynamic therapy, photothermal therapy, targeted therapy, drug delivery, gene delivery, protein delivery, and other biomedical fields is introduced. The latest progress of CDs with its own biomedical function in antioxidant, anti-pathogen, and disease treatment is summarized. Finally, we discuss some problems in the practical application of CDs and look forward to the future development trend of self-functional CDs combined with surface modification to achieve multimodal treatment of diseases.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88845060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced strategies of scaffolds design for bone regeneration 骨再生支架设计的先进策略
BMEMat Pub Date : 2023-09-02 DOI: 10.1002/bmm2.12046
Jian Song, Longfei Li, Lei Fang, Enshuo Zhang, Yu Zhang, Zhuxuan Zhang, Pranav Vangari, Yaqin Huang, Feng Tian, Yu Zhao, Wei Chen, Jiajia Xue
{"title":"Advanced strategies of scaffolds design for bone regeneration","authors":"Jian Song,&nbsp;Longfei Li,&nbsp;Lei Fang,&nbsp;Enshuo Zhang,&nbsp;Yu Zhang,&nbsp;Zhuxuan Zhang,&nbsp;Pranav Vangari,&nbsp;Yaqin Huang,&nbsp;Feng Tian,&nbsp;Yu Zhao,&nbsp;Wei Chen,&nbsp;Jiajia Xue","doi":"10.1002/bmm2.12046","DOIUrl":"10.1002/bmm2.12046","url":null,"abstract":"<p>Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects. In this review article, we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair, especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli. We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment. Finally, we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds, aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76283125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The progress of fabrication designs of polymeric microneedles and related biomedical applications 聚合物微针的制造设计进展及相关生物医学应用
BMEMat Pub Date : 2023-08-29 DOI: 10.1002/bmm2.12044
Xue Jiang, Wen Zhang, Richard Terry, Wei Li
{"title":"The progress of fabrication designs of polymeric microneedles and related biomedical applications","authors":"Xue Jiang,&nbsp;Wen Zhang,&nbsp;Richard Terry,&nbsp;Wei Li","doi":"10.1002/bmm2.12044","DOIUrl":"10.1002/bmm2.12044","url":null,"abstract":"<p>Microneedles (MNs) have been broadly used for transdermal delivery of a variety of drugs, ranging from small chemicals to biological macromolecules, due to the properties of increased drug permeability, minimal invasiveness and improved patient compliance. Despite these MNs can be made of different materials, such as metal, silicon, and glass, polymers have attracted the most attention as a microneedle (MN) matrix because of their excellent biocompatibility and biodegradability, which eliminates the requirement of MN removal after drug release. To satisfy different needs of transdermal drug delivery, polymeric MNs have been fabricated with several special designs. In this review, we summarize the advancement of the fabrication designs of polymeric MNs, including integrated MNs, two-segment MNs, core-shell or multi-layered MNs, and arrowhead MNs. The related biomedical applications of MNs with these different specific designs are also discussed. Finally, we provide our perspectives on the future development of polymeric MNs.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82842525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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