BMEMat Pub Date : 2024-08-16 DOI: 10.1002/bmm2.12115

Shumao Xu, Farid Manshaii, Jun Chen

引用次数: 0

One-dimensional nanomaterials for nerve tissue engineering to repair spinal cord injury 用于神经组织工程修复脊髓损伤的一维纳米材料

BMEMat Pub Date : 2024-08-02 DOI: 10.1002/bmm2.12111

Bingqi Shi, Shan Lu, Hongru Yang, Shahid Mahmood, Chunhui Sun, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Syafiqah Saidin, Congcong Zhang

{"title":"One-dimensional nanomaterials for nerve tissue engineering to repair spinal cord injury","authors":"Bingqi Shi, Shan Lu, Hongru Yang, Shahid Mahmood, Chunhui Sun, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Syafiqah Saidin, Congcong Zhang","doi":"10.1002/bmm2.12111","DOIUrl":"https://doi.org/10.1002/bmm2.12111","url":null,"abstract":"In recent years, tissue engineering has emerged as a cutting-edge approach for the treatment of spinal cord injury (SCI) owing to its remarkable capabilities. It can create living tissues with robust vitality, achieve maximal tissue repair with minimal cell usage, and facilitate seamless reconstruction with unmatched plasticity, all while addressing immune rejection issues. Among these advancements, one-dimensional (1D) materials have garnered significant attention. Their morphology closely resembles the extracellular matrix environment, thereby fostering the elongation of dendrites and axons on neurons and greatly enhancing the prospects for SCI repair. With a keen focus on the latest advancements in the application of 1D nanomaterials in nerve tissue engineering for spinal nerve repair, this review delves into several key aspects. Firstly, it explores the “bottom-up” approach to synthesizing 1D nanomaterials. Secondly, it examines the mechanisms by which these nanomaterials influence neural tissue engineering. Thirdly, it presents various cutting-edge strategies aimed at optimizing the morphology and performance of 1D materials, thereby enhancing the efficiency of nerve tissue injury repair. Lastly, it discusses the current challenges and future prospects facing this fascinating field. We aspire that this comprehensive review will provide a profound understanding of the development of 1D materials in neural tissue engineering and inspire a wider audience with its potential.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse thinking: Tumor nutritional therapy 逆向思维肿瘤营养疗法

BMEMat Pub Date : 2024-07-20 DOI: 10.1002/bmm2.12114

Binbin Ding, Ping'an Ma, Abdulaziz A. Al Kheraif, Jun Lin

引用次数: 0

Nano/genetically engineered cells for immunotherapy 用于免疫疗法的纳米/基因工程细胞

BMEMat Pub Date : 2024-07-17 DOI: 10.1002/bmm2.12112

Jingrui Shen, Yang Zhou, Lichen Yin

{"title":"Nano/genetically engineered cells for immunotherapy","authors":"Jingrui Shen, Yang Zhou, Lichen Yin","doi":"10.1002/bmm2.12112","DOIUrl":"10.1002/bmm2.12112","url":null,"abstract":"Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such as cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency and off-target toxicity of immunotherapeutic drugs. Nano drug delivery systems offer improvements in drug biodistribution and release kinetics but still suffer from shortcomings such as high immunogenicity, poor penetration across biological barriers, and insufficient tissue permeability. Targeted delivery of drugs using living cells has become an emerging strategy that can take advantage of the inherent characteristics of cells to deal with the delivery defects of nano delivery systems. Furthermore, cells themselves can be genetically engineered into cellular drugs for enhanced immunotherapy. This review provides an in-depth exploration of cell-derived drug carriers, detailing their biological properties, functions, and commonly used drug loading strategies. In addition, the role of genetically modified cells in immunotherapy and their synergistic therapeutic effects with drug delivery are also introduced. By summarizing the main advancements and limitations in the field, this review offers insights into the potential of cell-based drug delivery systems to address the existing challenges in immunotherapy. The introduction to recent developments and evaluation of ongoing research will pave the way for the optimization and widespread adoption of nano/genetically engineered cells for immunotherapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue clearing and its application in dental research 组织清理及其在牙科研究中的应用

BMEMat Pub Date : 2024-07-15 DOI: 10.1002/bmm2.12113

Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang

{"title":"Tissue clearing and its application in dental research","authors":"Lingxi Meng, Xinyu Song, Junyi Wang, Wenxuan Shi, Liheng Gao, Xinquan Jiang, Wenjie Zhang","doi":"10.1002/bmm2.12113","DOIUrl":"10.1002/bmm2.12113","url":null,"abstract":"For both animal and human tissues, translucence is an intrinsic property that gives them a milky appearance. This optical property arises due to the combined effects of light absorption and scattering and becomes the main impediment of deep imaging. To overcome these obstacles, the tissue-clearing technique has experienced a resurgence over the past century and evolved from its initial use in neuroscience to encompass various samples due to the emergence of various clearing methods. Notably, these techniques unveil both macroscopic and microscopic details, offering valuable insights into tissue structures. In particular, the oral cavity is structured with both soft and hard tissues at the macroscopic level and is rich in neurovascular networks microscopically, providing a suitable application environment for tissue-clearing techniques. Currently, tissue-clearing techniques have provided a powerful tool for research on the dental pulp neurovascular system, oral tissue regeneration, dental implants, and maxillofacial surgical treatments. Hence, this review aims to give a general introduction to tissue-clearing techniques and focus on their remarkable applications in dental research. At last, we will discuss the integration of tissue-clearing methods with other techniques such as labeling and microscopy, hoping to offer valuable insights for the development of tissue-clearing techniques in both bioscience and materials science.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine hitchhiking on bacteria for treating tumors 搭载细菌治疗肿瘤的纳米医学

BMEMat Pub Date : 2024-06-25 DOI: 10.1002/bmm2.12110

Shujing Zheng, Xingwei Li, Shutao Guo

{"title":"Nanomedicine hitchhiking on bacteria for treating tumors","authors":"Shujing Zheng, Xingwei Li, Shutao Guo","doi":"10.1002/bmm2.12110","DOIUrl":"https://doi.org/10.1002/bmm2.12110","url":null,"abstract":"Nanomedicine has shown promising therapeutic potential in cancer treatment, with clinically approved formulations such as Doxil® and Abraxane® already providing tangible benefits to patients. However, challenges such as low targeting efficiency and poor tumor penetration limit its application. Bacteria have emerged as promising drug delivery carriers due to their capacity for autonomous navigation and deep penetration into hypoxic tumor parenchyma. Therefore, utilizing bacteria as carriers for nanomedicine can partially overcome the limitations of anti-tumor nanomedicine. Moreover, some bacteria, like Salmonella typhimurium and Escherichia coli, exhibit immunostimulatory and oncolytic effects and can synergistically enhance the anti-tumor effects of nanomedicine. This article summarizes common types of bacteria and nanomedicines and their respective advantages and challenges in cancer treatment. It elaborates on various strategies for combining bacteria and nanomedicine under different administration routes, outlining the clinical progress and challenges of bacterial anti-tumor therapy and outlooking for future applications of utilizing bacteria as carriers for nanomedicine in cancer treatment.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering strategies to mitigate toxicities associated with CAR-T cell therapy 减轻CAR-T细胞治疗相关毒性的工程策略

BMEMat Pub Date : 2024-06-22 DOI: 10.1002/bmm2.12109

Tyler Wolter, Yixin Wang, Quanyin Hu

{"title":"Engineering strategies to mitigate toxicities associated with CAR-T cell therapy","authors":"Tyler Wolter, Yixin Wang, Quanyin Hu","doi":"10.1002/bmm2.12109","DOIUrl":"https://doi.org/10.1002/bmm2.12109","url":null,"abstract":"Chimeric antigen receptor (CAR) T cell therapy is a form of adoptive cell therapy that has revolutionized the field of cancer immunotherapy. Owing to the unprecedented efficacy seen in the treatment of blood cancers, the FDA has now approved multiple CAR T cell products for the treatment of various hematologic malignancies. Despite the clinical success seen in hematologic malignancies, CAR T cell therapies have demonstrated only modest efficacy in the treatment of solid tumors. Thus, great efforts are underway to increase the treatment efficacy in solid tumors and further enhance the treatment of hematologic malignancies. However, irrespective of advancements in efficacy, there are still unmet needs for patients receiving CAR T cell therapies. CAR T cell therapies carry significant risks of potentially fatal toxicities, and few of these toxicities were predicted in the animal models used to advance these therapies to the clinic. Therefore, significant advancements are needed to help reduce the incidence and severity of these toxicities to ultimately enhance patient safety and quality of life. This review will provide a brief overview of some of the major toxicities associated with CAR T cell therapies and will discuss the various engineering strategies used to mitigate such toxicities in preclinical models and clinical studies.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair 用于动态组织修复的扩散诱导相分离三维打印支架

BMEMat Pub Date : 2024-06-12 DOI: 10.1002/bmm2.12108

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

{"title":"Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair","authors":"Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi","doi":"10.1002/bmm2.12108","DOIUrl":"10.1002/bmm2.12108","url":null,"abstract":"Many hydrogen-bonded cross-linked hydrogels possess unique properties, but their limited processability hinders their potential applications. By incorporating a hydrogen bond dissociator (HBD) into these hydrogels, we developed injectable 3D printing inks termed diffusion-induced phase separation (DIPS) 3D printing inks. Upon extrusion into water and subsequent diffusion of HBD, these ink cure rapidly. The DIPS-printed scaffold retained most of the original hydrogel properties due to the regeneration of hydrogen bonds. Additionally, the reversible nature of hydrogen bonds provides DIPS 3D-printed scaffolds with exceptional recycling and reprinting capabilities, resulting in a reduction in the waste of valuable raw ink materials or additives. Postprocessing introduces new crosslinking methods that modulate the mechanical properties and degradation characteristics of DIPS scaffolds over a broad range. Based on its suitable mechanical properties and bioactivity, we successfully repaired and functionally reconstructed a complex defect in penile erectile tissue using the DIPS scaffold in a rabbit model. In summary, this approach is relevant for various hydrogen-bonded cross-linked hydrogels that offer mild printing conditions and enable the incorporation of bioactive agents. They can be used as scaffolds for dynamic tissue reconstruction, wearable devices, or soft robots.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice 甲氨蝶呤和赛拉司琼的生物仿生触发释放胶束制剂可控制小鼠胶原诱导的关节炎

BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12104

He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang

{"title":"A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice","authors":"He Ren, Zewen Wu, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang, Yumiao Zhang","doi":"10.1002/bmm2.12104","DOIUrl":"10.1002/bmm2.12104","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co-loading the anti-inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)-conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)-micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front-line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM-micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro-inflammatory responses. B cell membrane coating enhanced accumulation of CeViM-micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen-induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next-generation targeted RA treatment.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges 牙科和骨科钛植入物的混合涂层：当前的进展与挑战

BMEMat Pub Date : 2024-06-10 DOI: 10.1002/bmm2.12105

Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Zhou Ye

{"title":"Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges","authors":"Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Zhou Ye","doi":"10.1002/bmm2.12105","DOIUrl":"10.1002/bmm2.12105","url":null,"abstract":"Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult-to-treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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