BMEMat Pub Date : 2024-10-30 DOI: 10.1002/bmm2.12127

Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu

{"title":"The contribution of extracellular RNA and its derived biomaterials in disease management","authors":"Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu","doi":"10.1002/bmm2.12127","DOIUrl":"https://doi.org/10.1002/bmm2.12127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used as indicators of disease status or the physiological health of an organism. A large number of RNA-based biomaterials have been developed by simulating the biological function and structure of natural RNA molecules. The structural programmability of RNA-based biomaterials provides the spur for scientists to pioneer new approaches in disease detection and prevention. Nevertheless, the link between exRNA function and the design of RNA-based biomaterials has not been fully understood. Understanding the biological structure and function of exRNA will contribute to the clinical translation of this novel biotechnology. The present review discusses the research progress associated with exRNA and their derivatives to bridge the gap between natural exRNA and RNA-based biomaterials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects 用于增强x射线引发的癌症治疗的纳米材料：进展与前景

BMEMat Pub Date : 2024-10-25 DOI: 10.1002/bmm2.12122

Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan

{"title":"Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects","authors":"Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan","doi":"10.1002/bmm2.12122","DOIUrl":"https://doi.org/10.1002/bmm2.12122","url":null,"abstract":"<p>X-rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X-ray efficacy remains a critical challenge due to issues such as radiation resistance and damage to surrounding health tissues. Recent advancements in nanotechnology have introduced new opportunities and challenges in cancer diagnosis and treatment. This review summarizes the latest progress in nanomaterials for X-ray-triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, metal sulfides, metal fluorides, rare earth oxides, cluster compounds, metal-organic frameworks, and nanohybrids, enhance the effectiveness of X-ray-triggered treatments. Furthermore, we address the current challenges and future prospects of efficient X-ray-triggered cancer therapy, aiming to provide a comprehensive overview for researchers and clinicians in the field.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring 汗液驱动，皮肤粘附多模态传感器，用于长期和实时汗液监测

BMEMat Pub Date : 2024-10-22 DOI: 10.1002/bmm2.12124

Xinxin He, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yuyang Zeng, Jialin Li, Chun Ki Yiu, Yawen Yang, Jingkun Zhou, Guoqiang Xu, Jiachen Wang, Jian Li, Zitong Xu, Zhenlin Chen, Yiming Liu, Yuyu Gao, Binbin Zhang, Guangyao Zhao, Zhan Gao, Pengcheng Wu, Rui Shi, Yuze Qiu, Hehua Zhang, Lung Chow, Denglin Ye, Ya Huang, Xinge Yu

{"title":"Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring","authors":"Xinxin He, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yuyang Zeng, Jialin Li, Chun Ki Yiu, Yawen Yang, Jingkun Zhou, Guoqiang Xu, Jiachen Wang, Jian Li, Zitong Xu, Zhenlin Chen, Yiming Liu, Yuyu Gao, Binbin Zhang, Guangyao Zhao, Zhan Gao, Pengcheng Wu, Rui Shi, Yuze Qiu, Hehua Zhang, Lung Chow, Denglin Ye, Ya Huang, Xinge Yu","doi":"10.1002/bmm2.12124","DOIUrl":"https://doi.org/10.1002/bmm2.12124","url":null,"abstract":"<p>The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearable devices for physiological and biochemical monitoring, critical issues of power management and device/skin interfacial properties restrict the advancement of personalized healthcare and early disease detection. Here, we report a multimodal sweat monitoring device featuring a real-time display and long-term data analysis based on self-powered format of sweat-activated batteries (SABs). The polyvinyl alcohol-sucrose (PVA-Suc) hydrogel serves as the key component for the SAB, offering not only great long-term adhesive properties for conformable wearability but also significant power generation capabilities. A maximum current density of 44.06 mA cm<sup>−2</sup> and a maximum power density of 21.89 mW cm<sup>−2</sup> can be realized for the hydrogel based SAB. The resulting device integrates an advanced colorimetric and electrochemical sensor array to measure pH levels, glucose concentrations, and chloride ion levels in human sweat, with data wirelessly transmitted by Near Field Communication. The self-powering features and multiple mode sensing function offer sufficient power to support real-time monitoring of metabolic biomarkers in sweat, with the ability to visually observe changes in the colorimetric sensors for long-term data monitoring.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy 糖酵解干预诱导级联癌症治疗的自动代谢调节剂

BMEMat Pub Date : 2024-10-22 DOI: 10.1002/bmm2.12125

Jiao Zheng, Jian Zhang, Tian Zhang, Yongcun Yan, Sai Bi

{"title":"Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy","authors":"Jiao Zheng, Jian Zhang, Tian Zhang, Yongcun Yan, Sai Bi","doi":"10.1002/bmm2.12125","DOIUrl":"https://doi.org/10.1002/bmm2.12125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Effective intervention in glycolytic metabolism is a promising way to inhibit tumor malignant invasion. However, the inherent hypoxia environment and unitary regulating model subsequently compromise its therapeutic efficacy. Herein, a facile way to design an automatic metabolism modulator (auto-MMOD) is developed by loading glucose oxidase (GOx) and DNA-templated silver nanoclusters (DNA-AgNCs) into a pH-responsive zeolitic imidazolate frameworks-8 (ZIF-8) nanocarrier, which can activate a cascaded metal ion-killing effect during GOx-regulated glycolysis metabolism. When the acidic lysosome microenvironment induces ZIF-8 decomposition, the released GOx can effectively consume glucose and generate H<sub>2</sub>O<sub>2</sub>, thus inhibiting Adenosine Triphosphate synthesis and accelerating tumor starvation. Moreover, the released Ag<sup>+</sup> in response to H<sub>2</sub>O<sub>2</sub> can disturb bioenergy metabolism to inhibit tumor proliferation, which further enhances the tumor-killing effect in hypoxic microenvironments. This study achieves effective tumor suppression in vitro and in vivo by integrating ion therapy into glycolysis intervention, which establish a promising strategy for nano-theranostics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances of nanomaterials in imaging liver fibrosis 纳米材料在肝纤维化成像中的最新进展

BMEMat Pub Date : 2024-10-16 DOI: 10.1002/bmm2.12123

Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun

{"title":"Recent advances of nanomaterials in imaging liver fibrosis","authors":"Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun","doi":"10.1002/bmm2.12123","DOIUrl":"https://doi.org/10.1002/bmm2.12123","url":null,"abstract":"<p>Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix. If left untreated, it can progress to cirrhosis, liver failure, and even liver cancer. There is currently no efficient and accurate clinical diagnostic method for early liver fibrosis. Therefore, there is an urgent need to address the challenge of accurate staging and early diagnosis of liver fibrosis in clinical practice. Recently, nanomaterials have demonstrated significant potential for enhancing the diagnosis of liver fibrosis. Nanomaterials possess the ability to precisely identify and target the microenvironment associated with liver fibrosis. By enhancing their enrichment in the target area, nanomaterials can improve imaging contrast of fibrosis lesions in the liver, thereby enabling accurate diagnosis of liver fibrosis. Accordingly, this review delves into the latest research and advancements concerning nanomaterials in liver fibrosis diagnosis.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sacrificial strategy towards the formation of vascular-like networks in volumetric tissue constructs 体积组织结构中血管样网络形成的牺牲策略

BMEMat Pub Date : 2024-10-10 DOI: 10.1002/bmm2.12118

Christian Buckley, Rana Ibrahim, Felicia Giordano, Nuo Xu, Brandon Sems, Hongjun Wang

{"title":"Sacrificial strategy towards the formation of vascular-like networks in volumetric tissue constructs","authors":"Christian Buckley, Rana Ibrahim, Felicia Giordano, Nuo Xu, Brandon Sems, Hongjun Wang","doi":"10.1002/bmm2.12118","DOIUrl":"https://doi.org/10.1002/bmm2.12118","url":null,"abstract":"<p>The fields of tissue engineering and regenerative medicine have made astounding progress in recent years, evidenced by cutting-edge 4D printing technologies, precise gene editing tools, and sustained long-term functionality of engineered tissue grafts. Despite these fantastic feats, the clinical success of tissue-engineered constructs so far remains limited to only those relatively simple types of tissues such as thin bilayer skin equivalents or avascular cartilage. On the other hand, volumetric tissues (larger than a few millimeters in all dimensions), which are highly desirable for clinical utility, suffer from poor oxygen supply due to limited dimensional diffusion. Notably, large, complex tissues typically require a vascular network to supply the growing cells with nutrients for metabolic demands to prolong viability and support tissue formation. In recognition, extensive efforts have been made to create vascular-like networks in order to facilitate mass exchange through volumetric scaffolds. This review underlines the urgent need for continued research to create more complex and functional vascular networks, which is crucial for generating viable volumetric tissues, and highlights the recent advances in sacrificial template-enabled formation of vascular-like networks.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning integrated graphene oxide-based diagnostics, drug delivery, analytical approaches to empower cancer diagnosis 机器学习集成了基于氧化石墨烯的诊断、药物输送和分析方法，从而增强了癌症诊断的能力

BMEMat Pub Date : 2024-09-28 DOI: 10.1002/bmm2.12117

Suparna Das, Hirak Mazumdar, Kamil Reza Khondakar, Ajeet Kaushik

{"title":"Machine learning integrated graphene oxide-based diagnostics, drug delivery, analytical approaches to empower cancer diagnosis","authors":"Suparna Das, Hirak Mazumdar, Kamil Reza Khondakar, Ajeet Kaushik","doi":"10.1002/bmm2.12117","DOIUrl":"https://doi.org/10.1002/bmm2.12117","url":null,"abstract":"<p>Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)-based devices with ML techniques. The production techniques and functionalization tactics used to modify the physicochemical characteristics of GO for specific drug delivery are explained at the outset of the investigation. GO is a great option for treating cancer because of its natural biocompatibility and capacity to absorb medicinal chemicals. Then, complicated biological data are analyzed using ML algorithms, which make it possible to identify the best medicine formulations and individualized treatment plans depending on each patient's particular characteristics. The study also looks at optimizing and predicting the interactions between GO carriers and cancer cells using ML. Predictive modeling helps ensure effective payload release and therapeutic efficacy in the design of customized drug delivery systems. Furthermore, tracking treatment outcomes in real time is made possible by ML algorithms, which permit adaptive modifications to therapy regimens. By optimizing medication doses and delivery settings, the combination of ML and GO in cancer therapy not only decreases adverse effects but also enhances treatment accuracy.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair (3/2024) 用于动态组织修复的扩散诱导相分离三维打印支架 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12119

Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi

引用次数: 0

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024) 基于感染反应多糖的载药纳米组件，用于抗耐药细菌肺部感染的双模式治疗 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI: 10.1002/bmm2.12120

Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu

引用次数: 0

Principles of lipid nanoparticle design for mRNA delivery 用于mRNA递送的脂质纳米颗粒设计原理

BMEMat Pub Date : 2024-09-19 DOI: 10.1002/bmm2.12116

Yiran Zhang, Xinyue Zhang, Yongsheng Gao, Shuai Liu

{"title":"Principles of lipid nanoparticle design for mRNA delivery","authors":"Yiran Zhang, Xinyue Zhang, Yongsheng Gao, Shuai Liu","doi":"10.1002/bmm2.12116","DOIUrl":"https://doi.org/10.1002/bmm2.12116","url":null,"abstract":"<p>mRNA therapeutics have significantly evolved within the life sciences, particularly in applications such as vaccines, tumor immunotherapy, protein replacement, gene editing, and monoclonal antibody therapy. To fully realize the potential of mRNA drugs and mitigate the adverse effects, substantial vector materials have been developed for delivery of these pharmaceutical agents. Lipid nanoparticles (LNPs) represent the most clinically advanced mRNA carriers, recognized by U.S. Food and Drug Administration approved mRNA vaccines and numerous clinical trials. Diverse therapeutic applications necessitate tailored design of LNPs. Herein, we outline the principles of LNP design for mRNA delivery, focusing specifically on their effectiveness, targeting capabilities, safety profiles, and nanoparticle stability. Additionally, we present the latest advancements in mRNA-LNP technology. This review aims to elucidate the benefits and design principles of LNP delivery systems for mRNA therapeutics, providing insights into breakthroughs and innovative ideas for further enhancing these advantages. These summaries are dedicated to promoting the broader applications of LNP-mRNA drugs, aiming to advance the treatment of serious diseases in an effective and safe manner.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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