BMEMat最新文献

{"title":"Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities","authors":"Qiuming Pan,&nbsp;Ye Zhu,&nbsp;Zhi Ye,&nbsp;Huayang Zhang,&nbsp;Junxi Wang,&nbsp;Guozhong Yi,&nbsp;Zhiyong Li,&nbsp;Rongyang Xu,&nbsp;Luyao Wang,&nbsp;Zhenzhen Wu,&nbsp;Songtao Qi,&nbsp;Guanglong Huang,&nbsp;Shanqiang Qu","doi":"10.1002/bmm2.12137","DOIUrl":"https://doi.org/10.1002/bmm2.12137","url":null,"abstract":"<p>Cellular senescence is characterized by a sustained and irreversible cessation of cell proliferation in response to diverse environmental stimuli. However, senescent cells exhibit strong metabolic activity and release a range of cytokines and inflammatory mediators into the tumor microenvironment, collectively referred to as the senescence-associated secretory phenotype (SASP). In recent years, to develop new therapies for cancers, researchers have conducted extensive studies on the mechanism of cancer cell senescence and revealed that induction of cancer cell senescence could effectively suppress cancer progression. However, it has been documented that cellular senescence not only inhibits cancer initiation but also contributes significantly to cancer progression in some cases. Hence, it is imperative to comprehend the correlation between cellular senescence and tumorigenesis, and discuss the potential utilization of cellular senescence mechanisms to suppress cancer progression, which lays a theoretical foundation for new drugs to treat cancers. In this review, we first provide an overview of the discovery of cellular senescence and its key milestone events. Meanwhile, this review examines the major stimulus for the induction of senescence, and provides an overview of the categorization of cellular senescence. Subsequently, an examination of the primary regulatory mechanisms of cellular senescence is discussed, followed by a summary of the control of the SASP expression and its dual biological roles in cancers. Additionally, we also provide an overview of common biomarkers utilized in the identification of cellular senescence. Finally, this review investigates the efficacy of the “One-Two punch” sequential treatment approach for cancers, and examines the emerging challenges of this novel approach.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial hydrogel: The sniper of chronic wounds","authors":"Shengtai Bian,&nbsp;Huijun Ye,&nbsp;Pan Wang,&nbsp;Changxing Li,&nbsp;Xutao Guo,&nbsp;Ming Guan,&nbsp;Shilun Feng","doi":"10.1002/bmm2.12135","DOIUrl":"https://doi.org/10.1002/bmm2.12135","url":null,"abstract":"<p>Chronic wounds are wounds that are difficult to heal or do not follow the normal healing process. These include pressure ulcers, diabetic ulcers, venous ulcers, and arterial incomplete ulcers. Unlike acute wounds, chronic wounds are often difficult to heal or even do not heal. Its pathogenesis involves many factors; bacterial infection is the main cause of chronic wound. With the increase in population aging, the incidence of chronic wounds has become a critical issue in the current medical and health field. Management of chronic wounds is faced with the problems of long treatment time, difficulty, high cost, repeated attacks and high disability rate, which seriously threaten patients' ability to take care of themselves in normal life and cause a heavy burden to individuals, families and society. Over the past few years, the development of antibacterial hydrogels for the treatment of bacterial infections has received a lot of attention. Since antibacterial hydrogels not only have the mechanical properties of hydrogels, high biocompatibility and adjustable functional structure, but also have excellent antibacterial properties, they may be an ideal dressing to solve the problem of chronic wound healing. This article introduces the types of chronic wounds, their healing characteristics, and the challenges faced in treating chronic wounds. It classifies antimicrobial hydrogels based on their antimicrobial modes and further discusses the advancements in smart antimicrobial hydrogels along with the benefits and obstacles of using antimicrobial hydrogels in the treatment of chronic wounds. This article also explores the development directions of antimicrobial hydrogels for chronic wound management.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural electrodes for brain-computer interface system: From rigid to soft","authors":"Dan Yang,&nbsp;Gongwei Tian,&nbsp;Jianhui Chen,&nbsp;Yan Liu,&nbsp;Esha Fatima,&nbsp;Jichuan Qiu,&nbsp;Nik Ahmad Nizam Nik Malek,&nbsp;Dianpeng Qi","doi":"10.1002/bmm2.12130","DOIUrl":"https://doi.org/10.1002/bmm2.12130","url":null,"abstract":"<p>Brain-computer interface (BCI) is an advanced technology that establishes a direct connection between the brain and external devices, enabling high-speed and real-time information exchange. In BCI systems, electrodes are key interface devices responsible for transmitting signals between the brain and external devices, including recording electrophysiological signals and electrically stimulating nerves. Early BCI electrodes were mainly composed of rigid materials. The mismatch in Young's modulus between rigid electrodes and soft biological tissue can lead to rejection reactions within the biological system, resulting in electrode failure. Furthermore, rigid electrodes are prone to damaging biological tissues during implantation and use. Recently, flexible electrodes have garnered attention in the field of brain science research due to their better adaptability to the softness and curvature of the brain. The design of flexible electrodes can effectively reduce mechanical damage to neural tissue and improve the accuracy and stability of signal transmission, providing new tools and methods for exploring brain function mechanisms and developing novel neural interface technologies. Here, we review the research advancements in neural electrodes for BCI systems. This paper emphasizes the importance of neural electrodes in BCI systems, discusses the limitations of traditional rigid neural electrodes, and introduces various types of flexible neural electrodes in detail. In addition, we also explore practical application scenarios and future development trends of BCI electrode technology, aiming to offer valuable insights for enhancing the performance and user experience of BCI systems.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic T-cell and local macrophage interactions mediate granule size-dependent biological hydroxyapatite foreign body reaction","authors":"Yixiong Lin,&nbsp;Yang Zou,&nbsp;Jieting Yang,&nbsp;Zongpu Han,&nbsp;Xinyu Guo,&nbsp;Xiaomeng Gao,&nbsp;Jieyun Xu,&nbsp;Zhuohong Gong,&nbsp;Ruizhi Li,&nbsp;Zhipeng Li,&nbsp;Baoxin Huang,&nbsp;Yin Xiao,&nbsp;Feilong Deng,&nbsp;Zetao Chen","doi":"10.1002/bmm2.12133","DOIUrl":"https://doi.org/10.1002/bmm2.12133","url":null,"abstract":"<p>Biological hydroxyapatite (BHA) has been widely used in alveolar bone augmentation, while unfavorable outcomes can still be encountered. Among several reasons, we noticed a chaotic granule size application issue. The principle behind the choice of proper granule size mainly lies in the fitness of defect shape and size. However, granule size has been shown to elicit significant biological effects, with the underlying mechanisms still unknown. BHA granules of five different sizes were first prepared and characterized to investigate their biological effects. We found that the biomimetic porous structure of BHA gradually disappeared with decreasing size, affecting the structure of the blood clot fibrin network, leading to different local immune microenvironments and foreign body reactions (FBRs). Among them, &lt;0.2 mm BHA granules completely lost their biomimetic porous structure and their fibrin network was loosened with strong immune response and strongest FBR. We found Gata3 (+)/Nfat3 (+) Th2 cells were recruited from activated systemic immune organs, inducing CD206 (+)/CD163 (low) M2 macrophages through direct contact with Ptprc-Mrc1, thereby promoting their fusion to form foreign body giant cells leading to strong FBR. This study expanded the understanding of the size effect of BHA granules from a biological perspective and unveiled the mechanisms of systemic immune towards BHA mediated FBR, providing regulatory targets to improve bone regeneration outcomes.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering antibodies with cancer-associated binding sites","authors":"Yinqi Tian,&nbsp;Yumeng Pan,&nbsp;Yingchun Zhang,&nbsp;Fangling Wang,&nbsp;Zejun Wang","doi":"10.1002/bmm2.12134","DOIUrl":"https://doi.org/10.1002/bmm2.12134","url":null,"abstract":"<p>Cancer immunotherapy has appeared as a prospective therapeutic modality. Therapeutic antibodies induced in an in vitro expression system act as “targeting missiles” against tumor-associated binding sites, and subsequently, immune system attack on tumors is restored or boosted. These antibody regimens are engineered towards enhanced Fc efficacy, humanization, and fragmentation to specifically recognize and bind to effective tumor-associated targets. The challenge lies in obtaining efficient therapeutic regimens with low response rates, acquisition of resistance, and immune-related undesirable effects of artificially designed therapeutic antibodies, which is crucial for enhancing clinical efficacy. This review provides an in-depth introduction to antibodies that perform direct/indirect roles in cancer treatment by binding to immune checkpoints, co-stimulatory receptors, and extracellular membrane receptors. It also discusses how antibodies kill tumors and modulate microenvironment of tumor through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different specificities. Understanding antibody sources, ongoing evaluation of engineered antibodies, and tumor-associated antigen research pave the way for designing appropriate antibody-based immunotherapy regimens.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine hitchhiking on bacteria for treating tumors (4/2024)","authors":"Shujing Zheng,&nbsp;Xingwei Li,&nbsp;Shutao Guo","doi":"10.1002/bmm2.12131","DOIUrl":"https://doi.org/10.1002/bmm2.12131","url":null,"abstract":"<p>Taking advantage of autonomous navigation and deep penetration capabilities of bacteria, the use of bacteria as carriers for nanomedicine has attracted significant attention. In the review (DOI: 10.1002/bmm2.12110), Shujing Zheng, Xingwei Li, and Shutao Guo have systematically summarized current strategies for integrating bacteria and nanomedicines through different administration routes, highlighting both the clinical progress and the challenges faced in bacterial-based anti-tumor therapies. They have provided a perspective on the future development of nanomedicine hitchhiking on bacteria for cancer treatment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (4/2024)","authors":"He Ren,&nbsp;Zewen Wu,&nbsp;Jingxuan Li,&nbsp;Nan Zhang,&nbsp;Coo Yee Nah,&nbsp;Jiexin Li,&nbsp;Jingyu Zhang,&nbsp;Jonathan F. Lovell,&nbsp;Liyun Zhang,&nbsp;Yumiao Zhang","doi":"10.1002/bmm2.12132","DOIUrl":"https://doi.org/10.1002/bmm2.12132","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12104, He Ren, Zewen Wu, Liyun Zhang, Yumiao Zhang and their co-authors designed an antirheumatic nanoparticle termed CeViM-micelle@B. A methotrexate-conjugated Pluronic F127 micelle was developed to encapsulate anti-inflammatory agent Celastrol (Cel) and the stabilizer Vitamin K (VK), which was further coated by B-cell membrane. The use of CeViM-micelle@B significantly increased drug accumulation at pathological synovial joints, potently inhibited immune cell activation, and effectively prevented erosion of bone and cartilage. This new nanoplatform holds potential for the next-generation targeted rheumatoid arthritis therapy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver organoids: From 3D printing to biomedical applications","authors":"Ying Shi,&nbsp;Xin Han,&nbsp;Zheng Zhang,&nbsp;Jiangtao Xu,&nbsp;Guozhen Liu","doi":"10.1002/bmm2.12129","DOIUrl":"https://doi.org/10.1002/bmm2.12129","url":null,"abstract":"<p>The liver is an immune organ, especially an immune tolerance organ. The critical shortage of donor organs and disease models for the treatment of end-stage liver failure underscores the urgent need for the generation of liver organoids from human induced pluripotent stem cells (iPSCs). Notably, significant advancements have been made in the study of liver organoids over the past decade. The construction of liver organoids has transitioned from single cell type to multicellular models, and from two-dimensional to three-dimensional cultures. Here we provide the progress surrounding the different liver organoids culture techniques from 3D printing to organ-on-chip, as well as focuses on the present and future applications of liver organoids, and then to present challenges and perspectives ahead for further advancement.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple approach to biophysical profiling of blood cells in extranodal NK/T cell lymphoma patients using deep learning-integrated image cytometry","authors":"Seongcheol Park,&nbsp;Sang Eun Yoon,&nbsp;Youngho Song,&nbsp;Changyu Tian,&nbsp;Changi Baek,&nbsp;Hyunji Cho,&nbsp;Won Seog Kim,&nbsp;Seok Jin Kim,&nbsp;Soo-Yeon Cho","doi":"10.1002/bmm2.12128","DOIUrl":"https://doi.org/10.1002/bmm2.12128","url":null,"abstract":"<p>Extranodal NK/T cell lymphoma (ENKTL) poses significant challenges in efficient treatment processes due to its aggressive nature and high recurrence rates. There is a critical need to develop a robust statistical model to predict treatment efficacy by dynamically quantifying biomarkers tailored to various stages of lymphoma. Recent analytics such as sequencing and microbiome tests have only been utilized to understand lymphoma progression and treatment response in clinical settings. However, these methods are limited by their quantitative analysis capabilities, long turnaround times, and lack of single-cell resolution, which are essential for understanding the heterogeneous nature of lymphoma. In this study, we developed a deep learning-enhanced image cytometry (DLIC) to investigate biophysical heterogeneities in peripheral blood mononuclear cells (PBMCs) from newly diagnosed (ND) ENKTL patients. We established a substantial cohort of 23 ND ENKTL patients, categorizing them into interim of treatment (<i>n</i> = 21) and end of treatment (<i>n</i> = 19) stages along their serial treatment timelines. Using a basic optical microscope and a commercial microchip, we analyzed over 270,000 single PBMCs in high-throughput, profiling their size, eccentricity, and refractive index in a completely label-free and quantified manner through AI-based nanophotonic computation. We observed distinct heterogeneity variations in these three biophysical indicators across treatment stages and relapse statuses, revealing solid mechanistic correlations among the phenotypes. We established a three-dimensional single-cell distribution map for ENKTL patients and created a standard for quantifying the change in occupational volume. Leveraging this extensive database, DLIC offers on-site analytics in clinical settings, facilitating treatment assessment and prognosis prediction through label-free biophysical analysis of patient PBMCs, extracted directly without additional sample preparation.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjugated polymers as photocatalysts for hydrogen therapy","authors":"Feixue Mi,&nbsp;Ningjing Zhao,&nbsp;Lingyue Jin,&nbsp;Ziyi Zhang,&nbsp;Xinyu Wang,&nbsp;Xiaofeng Fang,&nbsp;Wenting Li,&nbsp;Zhao Liu,&nbsp;Peng Shu,&nbsp;Xuanjun Zhang,&nbsp;Changfeng Wu","doi":"10.1002/bmm2.12126","DOIUrl":"https://doi.org/10.1002/bmm2.12126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Hydrogen as a therapeutic agent has attracted a great deal of attention because of its superior therapeutic outcome on many diseases, including inflammatory injury, tumors, metabolic disorders, and neurological diseases. Photocatalytic hydrogen evolution has emerged as a promising strategy for hydrogen production and delivery. This review article presents the recent developments in the design and synthesis of conjugated polymer materials, including linear polymers and crosslinked conjugated materials, for photocatalytic hydrogen evolution. Particularly, we focus this review on the development of conjugated polymers as photocatalysts and the resulting hydrogen therapy in the fields of anti-inflammatory, free radical scavenging, and cancer treatment. Finally, this article discusses the future research and perspective of conjugated polymer materials for hydrogen evolution and the potential clinical applications of hydrogen as a therapeutic agent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}