BMEMat最新文献

{"title":"Prosthetic heart valves for transcatheter aortic valve replacement","authors":"Xinman Hu,&nbsp;Shifen Li,&nbsp;Pai Peng,&nbsp;Beiduo Wang,&nbsp;Wenxing Liu,&nbsp;Xiaofei Dong,&nbsp;Xiayan Yang,&nbsp;Miroslav Karabaliev,&nbsp;Qifeng Yu,&nbsp;Changyou Gao","doi":"10.1002/bmm2.12026","DOIUrl":"https://doi.org/10.1002/bmm2.12026","url":null,"abstract":"<p>Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long-term implantation. Therefore, the anti-calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti-calcification modification strategies. Besides, the development of new polymeric valves is included, with special attention to representative cases, such as polysiloxane, polytetrafluorethylene, poly(styrene-block-isobutylene-block-styrene), and polyurethane-based materials. Finally, the challenges and future perspectives of artificial heart valve materials are discussed.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50144483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aconitum carmichaelii triggers neurotoxicity and Parkinson-like symptoms through initiation of ROS-mitochondrial apoptosis and the Nox5/DJ-1 signaling pathway","authors":"Meijun Pang,&nbsp;Xin Song,&nbsp;Yaodong Miao,&nbsp;Yiwen Wang,&nbsp;Chang Zhou,&nbsp;Zihan Geng,&nbsp;Jiayin Du,&nbsp;Bernard Moussian,&nbsp;Yanfang Su,&nbsp;Xiuyun Liu,&nbsp;Dong Ming","doi":"10.1002/bmm2.12019","DOIUrl":"https://doi.org/10.1002/bmm2.12019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>\u0000 <i>Aconitum carmichaelii</i>, the mother root of <i>Aconitum</i>, has a long-applied history for treating many diseases in China. Increased use of it has prompted significant concerns regarding its extensive cardiotoxicity and neurotoxicity. The molecular mechanisms underlying <i>A. carmichaelii</i>-induced neurotoxicity are poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We took advantage of the zebrafish model to investigate the neurotoxic mechanism of <i>A. carmichaelii</i>. In addition to the behavior and neuronal activity testing, gene expression of neuronal oxidative stress, and apoptosis levels were also analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In contrast to the excitatory effect of low-dose <i>A. carmichaelii</i> decoction, hypoactivity of locomotor behavior, and neural activity, especially telencephalon, were detected in the 20 mg/mL group. High doses of <i>A. carmichaelii</i> induced excessive ROS by downregulating <i>DJ-1</i> and activating <i>Nox5</i>, and further triggered cell apoptosis through the <i>bax/bcl2a-caspase-9</i> pathway in zebrafish larva. Mitochondrial protection-related genes <i>PinK1</i> and <i>Parkin</i> were upregulated to protect against mitochondrial dysfunction during cellular stress. The ROS scavenger-NAC significantly alleviated neurotoxicity in the 20 mg/mL group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study reveals the potential mechanism of <i>A. carmichaelii</i>-induced neurotoxicity and provides new insights into a significant risk marker of <i>A. carmichaelii</i> poisoning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50123047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced near-infrared light approaches for neuroimaging and neuromodulation","authors":"Hongqiang Yin,&nbsp;Wuqiao Jiang,&nbsp;Yongyang Liu,&nbsp;Dongyang Zhang,&nbsp;Feng Wu,&nbsp;Yejun Zhang,&nbsp;Chunyan Li,&nbsp;Guangcun Chen,&nbsp;Qiangbin Wang","doi":"10.1002/bmm2.12023","DOIUrl":"https://doi.org/10.1002/bmm2.12023","url":null,"abstract":"<p>Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to brain diseases and disorders. Therefore, it' is greatly meaningful and urgent for scientists to have a better understanding of brain structure and function. Optical approaches can provide powerful tools for imaging and modulating physiological processes of the brain. In particular, optical approaches in the near-infrared (NIR) window (700–1700 nm) exhibit excellent prosperities of deep tissue penetration and low tissue scattering and absorption compared with those of visible windows (400–700 nm), which provides a promising approach for scientists to develop desired methods of neuroimaging and neuromodulation in deep brain tissues. In this review, variable types of NIR light approaches for imaging and modulating neural ions, membrane potential, neurotransmitters, and other critical molecules for brain functions and diseases are summarized. In particular, the latest breakthrough research of brain imaging and brain regulation in the NIR-II window (1000–1700 nm) are highlighted. Finally, we conclude the challenges and prospects of NIR light-based neuroimaging and neuromodulation for both basic brain research and further clinical translation.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50132543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin-based drug delivery system for tumor therapy","authors":"Zaiqian Tu,&nbsp;Peter Timashev,&nbsp;Junge Chen,&nbsp;Xing-Jie Liang","doi":"10.1002/bmm2.12022","DOIUrl":"https://doi.org/10.1002/bmm2.12022","url":null,"abstract":"<p>Ferritin has been widely used in drug delivery in recent years due to its unique spherical nanocage structure. In addition, the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery system. Therefore, ferritin has shown a broad application prospect in the field of nanomedicine. In this perspective, we will describe ferritin-based drug delivery system, ferritin-based drug delivery system for tumor treatment, and future challenges in ferritin development. Hopefully, this perspective may inspire the future development of ferritin-based drug delivery systems for tumor treatment.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50143947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases","authors":"Luming Zhao,&nbsp;Siew Yee Wong,&nbsp;Jia Yu Sim,&nbsp;Jin Zhou,&nbsp;Xu Li,&nbsp;Changyong Wang","doi":"10.1002/bmm2.12020","DOIUrl":"https://doi.org/10.1002/bmm2.12020","url":null,"abstract":"<p>Heart diseases pose a serious threat to human health, and their incidence has been increasing in recent years. In past decades, many strategies have been developed to decrease the mortality and morbidity of heart diseases, among them, strategies involving cardiac electronic devices (CEDs) have been effective in treating and preventing heart diseases. To allow the CEDs to work continuously without the need to replace batteries and to meet the requirements of convenience and comfort in the process of use, nanogenerator (NG)-based CEDs were proposed, widely studied, continuously optimized in recent years owing to their advantages of small dimensions, self-powering ability, and good biocompatibility. In this review, recent improvements of NG-based CEDs of two typical types (i.e., triboelectric nanogenerator [TENG] and piezoelectric nanogenerator [PENG]) and their structures and functions are summarized and discussed. The demands, remaining challenges, and future development trends of NG-based CEDs are also discussed.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50133263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive hydrogel dressings for intelligent wound management","authors":"Suxi Wang,&nbsp;Wen-Ya Wu,&nbsp;Jayven Chee Chuan Yeo,&nbsp;Xiang Yun Debbie Soo,&nbsp;Warintorn Thitsartarn,&nbsp;Songlin Liu,&nbsp;Beng Hoon Tan,&nbsp;Ady Suwardi,&nbsp;Zibiao Li,&nbsp;Qiang Zhu,&nbsp;Xian Jun Loh","doi":"10.1002/bmm2.12021","DOIUrl":"https://doi.org/10.1002/bmm2.12021","url":null,"abstract":"<p>Due to global aging problems, the rising number of patients suffering from chronic or hard-to-heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a complicated and dynamic physiological process with distinct molecular and cellular levels at each phase. Despite numerous strategies and advanced wound dressings being developed, successful wound management through smart dressing materials that can adapt to changing wound microenvironments and address the needs of wounds at different stages remains a big challenge. Over the last decade, hydrogel-based dressings have emerged as one of the most potent biomaterials for wound treatment with favorable biological characteristics and a high potential for active intervention during the wound-curing process. In the current contribution, we present the most recent progress in smart hydrogel dressings that can regulate the release of therapeutics in response to external stimuli (such as light) as well as endogenous changes in wound environments (e.g., temperature, pH, glucose, and reactive oxygen species) to facilitate wound healing. We also introduce the cutting-edge technologies of intelligent “sense-and-treat” dressings through a combination of built-in sensors or sensing molecules with responsive hydrogels, which enable real-time monitoring of wound conditions and prompt on-demand therapy.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50133262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advances in non-viral gene delivery systems: Liposomes versus extracellular vesicles","authors":"Zakia Belhadj,&nbsp;Yunkai Qie,&nbsp;Randy P. Carney,&nbsp;Yuanpei Li,&nbsp;Guangjun Nie","doi":"10.1002/bmm2.12018","DOIUrl":"https://doi.org/10.1002/bmm2.12018","url":null,"abstract":"<p>In the past decade, nucleic acid-based drugs have emerged as an extremely promising approach for silencing specific disease-related genes and targeting undruggable ones. However, most nucleic acid drug therapies have not advanced to clinical practice due to their poor stability against serum enzyme degradation and cytotoxicity. Nanoscale drug delivery vehicles show potential to improve efficacy of nucleic acid drugs via targeted delivery to disease-causing genes, yet, safe and efficient nanocarriers remain elusive. Lipid-based nanoparticles such as liposomes (LSs) and extracellular vesicles (EVs) are among the most extensively exploited nanoscale vehicles for therapeutic cargo delivery. LS-based nucleic acid therapies have been used for several years, with many already adopted to the clinic. More recently, EVs hold considerable promise as nucleic acid delivery vehicles due to their high biocompatibility, low immunogenicity, and the inherent abilities to interact with target cells and cross biological barriers. Moreover, a novel LS/EV hybrid gene delivery system has been engineered to preserve the benefits of both systems and generate an advanced drug delivery system. The current review focuses specifically on LS- and EV-based gene therapies and provides the key advantages and shortcomings of these systems with particular emphasis on their potential use as therapeutic vectors.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50139210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optofluidic identification of single microorganisms using fiber-optical-tweezer-based Raman spectroscopy with artificial neural network (BMEMat 1/2023)","authors":"Chenghong Lin,&nbsp;Xiaofeng Li,&nbsp;Tianli Wu,&nbsp;Jiaqi Xu,&nbsp;Zhiyong Gong,&nbsp;Taiheng Chen,&nbsp;Baojun Li,&nbsp;Yuchao Li,&nbsp;Jinghui Guo,&nbsp;Yao Zhang","doi":"10.1002/bmm2.12015","DOIUrl":"https://doi.org/10.1002/bmm2.12015","url":null,"abstract":"<p>Pathogenic microorganisms that cause diseases are like the hateful monsters in <i>Journey to the West</i>. With strong mobility, they keep wandering everywhere, making it very difficult to identify them in a great variety of species using conventional microscopes. In article number 10.1002/bmm2.12007, Y. Zhang et al. develop an optofluidic method for identifying single microorganisms in microfluidic channels using fiber-optical-tweezer-based Raman spectroscopy with artificial neural network. Such a method is just like Sun Wukong (also called the Great Sage Equalling Heaven in the same fiction) who owns the super power of “Immobilization Spell” that traps the pathogenic microorganisms and “Piercing Eyes” that rapidly and accurately identify the microbial species.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50116540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Powered High-Resolution Smart Insole System for Plantar Pressure Mapping (BMEMat 1/2023)","authors":"Qiuqun Zheng,&nbsp;Xingyi Dai,&nbsp;Yinghui Wu,&nbsp;Qihua Liang,&nbsp;Yongpeng Wu,&nbsp;Jingkun Yang,&nbsp;Biqin Dong,&nbsp;Guojun Gao,&nbsp;Qi Qin,&nbsp;Long-Biao Huang","doi":"10.1002/bmm2.12016","DOIUrl":"https://doi.org/10.1002/bmm2.12016","url":null,"abstract":"<p>In article number 10.1002/bmm2.12008, Xingyi Dai, Qi Qin, Long-Biao Huang, and co-workers report a self-powered wearable plantar pressure mapping system with a high spatial resolution. The smart insole system with 44-pixel sensor array based on triboelectric nanogenerators (TENGs) can be used to accurately monitor the plantar pressure. Different gaits and motion states can be discriminated.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50116538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-II absorbing organic nanoagents for photoacoustic imaging and photothermal therapy (BMEMat 1/2023)","authors":"Wei Shao,&nbsp;Fulai Zhao,&nbsp;Jinhong Xue,&nbsp;Lingling Huang","doi":"10.1002/bmm2.12014","DOIUrl":"https://doi.org/10.1002/bmm2.12014","url":null,"abstract":"<p>In article number 10.1002/bmm2.12009, Wei Shao, Lingling Huang, and their co-workers have systematically summarized the current advances in NIR-II absorbing organic nanoagents (ONAs) for phototheranostics. They have described the NIR-II photoacoustic imaging (PAI) of ONAs for tumors, stem cells, and vasculature. In addition, they have also discussed the NIR-II photothermal therapy (PTT) of ONAs for tumors, bacteria, and rheumatoid arthritis.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50116541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}