BMEMat Pub Date : 2024-03-01 DOI: 10.1002/bmm2.12074

Min Hao, Wenhan Wang, Anil Kumar, Wan Hairul Anuar Kamaruddin, Syafiqah Saidin, Nik Ahmad Nizam Nik Malek, Jerome Claverie, Hong Liu

引用次数: 0

Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti-inflammation, and regeneration 用于改善骨关节炎的水凝胶：机械调节、抗炎和再生

BMEMat Pub Date : 2024-03-01 DOI: 10.1002/bmm2.12078

Xuwei Jiang, Yuxiang Sun, Yuanning Lyu, Heemin Kang, Jianyang Zhao, Kunyu Zhang, Liming Bian

{"title":"Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti-inflammation, and regeneration","authors":"Xuwei Jiang, Yuxiang Sun, Yuanning Lyu, Heemin Kang, Jianyang Zhao, Kunyu Zhang, Liming Bian","doi":"10.1002/bmm2.12078","DOIUrl":"10.1002/bmm2.12078","url":null,"abstract":"Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis and develop treatments against OA. Hydrogels, designed with a striking resemblance to the extracellular matrix, offer a biomimetic interaction with biological tissues, presenting a promising avenue for OA amelioration. As a result, biocompatible hydrogels have been erected incorporating on-demand bioactivities to optimize the intra-articular microenvironment, thereby alleviating OA symptoms and fostering the eventual regeneration of articular joints. This review highlights the collaborative objectives underlying the establishment of this tissue microenvironment, encompassing mechanical modulation, anti-inflammation, and tissue regeneration. Specifically, we consolidate recent advances in hydrogel-based biomaterials, serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent-loaded vehicles to combat localized inflammation. Additionally, hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage regeneration. Finally, this review outlines the prospective directions for hydrogel-mediated OA therapies.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy 金属配位驱动组装用于肿瘤化疗免疫疗法的干扰素基因激活剂纳米粒子

BMEMat Pub Date : 2024-02-27 DOI: 10.1002/bmm2.12077

Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui

{"title":"Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy","authors":"Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui","doi":"10.1002/bmm2.12077","DOIUrl":"10.1002/bmm2.12077","url":null,"abstract":"Activating the stimulator of interferon genes (STING) signaling pathway is critical for enhancing antitumor immunity and remodeling the immunosuppressive tumor microenvironment (TME). Herein, we report the preparation of STING-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist (i.e., SR717) and a chemotherapeutic drug (i.e., curcumin). After intravenous administration, the assembled nanoparticles could efficiently accumulate in tumors to improve the bioavailability of SR717 and trigger potent STING pathway activation for effective immune responses. Meanwhile, the released curcumin evokes immunogenic cell death in tumors and regulates amino acid metabolism by inhibiting the activation of indoleamine 2,3-dioxygenase 1, leading to the reversal of the immunosuppressive TME. The antitumor immunity induced by nanoparticles significantly inhibits the growth of primary, recurrent, and metastatic tumors. The assembled nanoparticles are promising for the co-delivery of STING agonists and drugs in improved tumor chemo-immunotherapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of novel carbon-based biomedical platforms for intervention in xenotoxicant-induced Parkinson's disease onset 开发新型碳基生物医学平台，用于干预异毒素诱发的帕金森病发病

BMEMat Pub Date : 2024-01-27 DOI: 10.1002/bmm2.12072

Jyotish Kumar, Armando Varela-Ramirez, Mahesh Narayan

{"title":"Development of novel carbon-based biomedical platforms for intervention in xenotoxicant-induced Parkinson's disease onset","authors":"Jyotish Kumar, Armando Varela-Ramirez, Mahesh Narayan","doi":"10.1002/bmm2.12072","DOIUrl":"10.1002/bmm2.12072","url":null,"abstract":"Chronic exposure to herbicides, weedicides, and pesticides is associated with the onset and progress of neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Here, we have investigated whether quinic- and chlorogenic-acid-derived Carbon Quantum Dots (QACQDs and ChACQDs, respectively) protect against a (pesticide) paraquat-insult model of PD. Our results indicated that both types of CQDs intervened in the soluble-to-toxic transformation of the amyloid-forming model protein Hen Egg White Lysozyme (HEWL). Furthermore, QACQDs and ChACQDs demonstrated antioxidant activity while remaining biocompatible in a human neuroblastoma-derived cell line (SH-SY5Y) up to 5 mg/ml and protected the cell line from the environmental neurotoxicant (paraquat). Importantly, both CQDs were found to protect dopaminergic neuronal ablation in a paraquat model of Parkinson's disease using the nematode C. elegans. Our results are significant because both plant-derived organic acids cross the blood–brain barrier, making them attractive for developing CQD architectures. Furthermore, since the synthesis of these CQDs was performed using green chemistry methods from precursor acids that cross the BBB, these engineered bionanomaterial platforms are tantalizing candidates for preventing neurodegenerative disorders associated with exposure to environmental neurotoxicants.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post-surgery 用于预防结肠直肠癌术后复发的黏附性和防污性 Janus 多糖薄膜

BMEMat Pub Date : 2024-01-22 DOI: 10.1002/bmm2.12071

Jaebeom Lee, Hee Seung Seo, Chun Gwon Park, Mikyung Shin

{"title":"Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post-surgery","authors":"Jaebeom Lee, Hee Seung Seo, Chun Gwon Park, Mikyung Shin","doi":"10.1002/bmm2.12071","DOIUrl":"10.1002/bmm2.12071","url":null,"abstract":"Colorectal cancer is one of the most common cancers, and current treatment options include surgery, chemotherapy, and radiation therapy. Most patients undergo surgery, which often requires extensive resection of the colon to prevent recurrence and metastasis of residual malignant tumor cells, leading to postoperative pain and discomfort in daily routines. Although versatile therapeutic patches have been developed to induce tumor apoptosis, achieving both great adhesiveness on the mucus layers of the colon tissue and anti-cell/tissue adhesion to other surrounding organs remains a challenge. Herein, we report a Janus polysaccharide film comprising two polymers: mussel-inspired catechol-conjugated chitosan (Chi-C) with muco-adhesiveness, and alginate (Alg) with anti-adhesion property. The Chi-C and Alg polymers form a stably entangled bilayer film via electrostatic interactions. The Janus film shows a strong tissue adhesive strength of ∼10 kPa for the Chi-C layer and weak strength of ∼1 kPa for the Alg layer. Particularly, the Janus film encapsulating an anti-cancer drug exhibits a directional release profile to the tumor site, which is effective for triggering tumor death in in vivo colorectal tumor resection model. Ultimately, such anti-cancer material strategies using bilayered structures are promising for advanced tumor therapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing diaphragmatic defect repair and regeneration: How biomaterials leading the way to progress? 加强膈肌缺损修复和再生：生物材料如何引领进步？

BMEMat Pub Date : 2024-01-21 DOI: 10.1002/bmm2.12070

Mojtaba Farahani, Przemysław Gnatowski, Raziyeh Najafloo, Tina Navaei, Edyta Piłat, Justyna Kucińska-Lipka, Mohammad Reza Saeb, Masoud Mozafari

{"title":"Enhancing diaphragmatic defect repair and regeneration: How biomaterials leading the way to progress?","authors":"Mojtaba Farahani, Przemysław Gnatowski, Raziyeh Najafloo, Tina Navaei, Edyta Piłat, Justyna Kucińska-Lipka, Mohammad Reza Saeb, Masoud Mozafari","doi":"10.1002/bmm2.12070","DOIUrl":"10.1002/bmm2.12070","url":null,"abstract":"Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations. Diaphragmatic hernias, such as Morgagni, Bochdalek, and Hiatus hernias, can result in congenital lesions that are often undiagnosed until the appearance of symptoms (bleeding, anemia, and acid reflux). Therefore, substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics. Recent research indicates promising mid-term performance for both natural and synthetic materials. However, studies exploring their application in diaphragm regeneration are limited and remain in the early research stages. Additionally, further investigation is required to address the constraints in human tissue supply for clinical implementation. This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration. It emphasizes biomaterials, including biomimetic polymers used in technological solutions. This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissue-engineered patches for clinical use.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139610143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory mechanisms and regeneration strategies of the soft–hard tissue interface in the human periodontium 人类牙周软硬组织界面的调节机制和再生策略

BMEMat Pub Date : 2024-01-13 DOI: 10.1002/bmm2.12069

Gao-peng Dang, Yu Wei, Qian-qian Wan, Jun-ting Gu, Kai-yan Wang, Mei-chen Wan, Chen-yu Wang, Jing-han Song, Zhao Mu, Franklin R. Tay, Li-na Niu

{"title":"Regulatory mechanisms and regeneration strategies of the soft–hard tissue interface in the human periodontium","authors":"Gao-peng Dang, Yu Wei, Qian-qian Wan, Jun-ting Gu, Kai-yan Wang, Mei-chen Wan, Chen-yu Wang, Jing-han Song, Zhao Mu, Franklin R. Tay, Li-na Niu","doi":"10.1002/bmm2.12069","DOIUrl":"10.1002/bmm2.12069","url":null,"abstract":"The soft-hard tissue interface of the human periodontium is responsible for periodontal homeostasis and is essential for normal oral activities. This soft-hard tissue interface is formed by the direct insertion of fibrous ligaments into the bone tissue. It differs from the unique four-layer structure of the fibrocartilage interface. This interface is formed by a combination of physical, chemical, and biological factors. The physiological functions of this interface are regulated by different signaling pathways. The unique structure of this soft-hard tissue interface has inspired scientists to construct biomimetic gradient structures. These biomimetic systems include nanofiber scaffolds, cell sheets, and hydrogels. Exploring methods to repair this soft-hard tissue interface can help solve clinically unresolved problems. The present review examines the structure of the soft-hard tissue interface of the periodontium and the factors that influence the development of this interface. Relevant regulatory pathways and biomimetic reconstruction methods are also presented to provide ideas for future research on interfacial tissue engineering.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines 基于聚合物纳米药物的癌症联合免疫疗法的先进策略

BMEMat Pub Date : 2024-01-12 DOI: 10.1002/bmm2.12067

Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li, Chao Feng, Lei Wang, Kuikun Yang

{"title":"Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines","authors":"Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li, Chao Feng, Lei Wang, Kuikun Yang","doi":"10.1002/bmm2.12067","DOIUrl":"10.1002/bmm2.12067","url":null,"abstract":"Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression, long-term protection from recurrence as well as minimized side effects, the low response rate significantly limits the clinical application of immunotherapy in board types of solid tumors. In order to improve the therapeutic efficacy, conventional therapies including radiotherapy, chemotherapy, phototherapy and chemodynamic therapy are employed to combine with immunotherapy to elicit stronger antitumor immune responses. Polymer nanomedicines are frequently utilized in synergistic immunotherapy and other therapies owing to their tunable physiochemical properties, high drug loading capacity, ease of modification and low toxicity. With elaborate design and tailored properties, polymer nanomedicines can significantly enhance antitumor efficacy by enhancing tumor specificity, priming immune cells and amplifying immune responses in tumors. However, until now, there is no review solely dedicated to the comprehensive development of polymer-based platforms for combinational immunotherapy of cancers. Herein, this paper summarizes latest advances in the design, fabrication and application of polymer nanomedicines in combinational immunotherapy and traditional antitumor strategies including radiotherapy, chemotherapy, photothermal therapy, photodynamic therapy and other therapies. An outlook on the trajectory and potential challenges of polymer nanomedicines in bridging the gap between immunotherapy and conventional therapies is also discussed.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-bio interactions between 2D nanomaterials and mononuclear phagocyte system cells 二维纳米材料与单核吞噬系统细胞之间的纳米生物相互作用

BMEMat Pub Date : 2024-01-10 DOI: 10.1002/bmm2.12066

Jing Zhao, Zheng Chen, Shanbiao Liu, Pin Li, Shiyi Yu, Daishun Ling, Fangyuan Li

{"title":"Nano-bio interactions between 2D nanomaterials and mononuclear phagocyte system cells","authors":"Jing Zhao, Zheng Chen, Shanbiao Liu, Pin Li, Shiyi Yu, Daishun Ling, Fangyuan Li","doi":"10.1002/bmm2.12066","DOIUrl":"10.1002/bmm2.12066","url":null,"abstract":"Two-dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly in the realms of immunotherapy for tissue engineering and tumor therapy. These applications necessitate a thorough assessment of the potential influence of 2D nanomaterials on immune cells. Notably, the mononuclear phagocyte system (MPS) cells, which play pivotal roles in both innate and adaptive immunity, are essential for maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to the prevention of foreign body invasion and the elimination of dead or senescent cells. Furthermore, MPS cells, including macrophages and dendritic cells, serve as vital bridges between innate and adaptive immune responses. Therefore, understanding the nano-bio interactions between 2D nanomaterials and MPS cells is imperative. These nano-bio interactions including cellular uptake, cytocompatibility, and immunological impact are invaluable for the purposeful design of 2D nanomaterials. Herein, we provide an overview of the latest advancements in understanding the nano-bio interactions between 2D nanomaterials and MPS cells, and discuss the current challenges and future prospects of employing 2D nanomaterials in the field of nanomedicine.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hexagonal boron nitride nanomaterials for biomedical applications 用于生物医学应用的六方氮化硼纳米材料

BMEMat Pub Date : 2024-01-03 DOI: 10.1002/bmm2.12068

Congling Wang, Yanyang Long, Yuxian Deng, Yuxin Han, Daria Tishkevich, Minh Ngoc Ha, Qunhong Weng

引用次数: 0

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