BMEMat最新文献

{"title":"Recent advances of nanomaterials in imaging liver fibrosis (2/2025)","authors":"Jin Cui,&nbsp;Shuxuan Zhang,&nbsp;Xueli Xu,&nbsp;Ke Ren,&nbsp;Mengzhen Dong,&nbsp;Zhaokun Nie,&nbsp;Yang Xu,&nbsp;Xiaohui Dai,&nbsp;Peng Xu,&nbsp;Shuo Sun,&nbsp;Xinya Zhao,&nbsp;Xiao Sun","doi":"10.1002/bmm2.70022","DOIUrl":"https://doi.org/10.1002/bmm2.70022","url":null,"abstract":"<p>Early diagnosis and accurate staging of liver fibrosis has emerged as a major focus and significant challenge in clinical research, attracting considerable scientific attention. In the review (DOI: 10.1002/bmm2.12123), Jin Cui, Xinya Zhao, and Xiao Sun systematically summarize current applications of various nanomaterials in liver fibrosis imaging, particularly utilization in targeting hepatic stellate cells and extracellular matrix components. Their work provides valuable insights and a robust reference framework for future developments in nanomaterials-based strategies for early detection and timely therapeutic intervention of liver fibrosis.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expertise-inspired artificial intelligence pipeline for clinically applicable reconstruction of tooth-centric radial planes: Development and multicenter validation","authors":"Zhuohong Gong,&nbsp;Gengbin Cai,&nbsp;Jiayang Zeng,&nbsp;Beichen Wen,&nbsp;Hengyi Liu,&nbsp;Jiahong Lin,&nbsp;Xiaofei Meng,&nbsp;Peisheng Zeng,&nbsp;Jiamin Shi,&nbsp;Rui Xie,&nbsp;Yang Yu,&nbsp;Yin Xiao,&nbsp;Mengru Shi,&nbsp;Ruixuan Wang,&nbsp;Zetao Chen","doi":"10.1002/bmm2.70010","DOIUrl":"https://doi.org/10.1002/bmm2.70010","url":null,"abstract":"<p>Owing to the tooth-centered nature of most oral diseases, the tooth-centric radial plane of cone-beam computed tomography (CBCT) depicts the anatomical and pathological features along the long axis of the tooth, serving as a crucial imaging modality in the diagnosis, treatment planning, and prognosis of multiple oral diseases. However, reconstructing these standard planes from CBCT is labor-intensive, time-consuming, and error-prone due to anatomical variances and multi-center discrepancies. This study proposes an expertise-inspired artificial intelligence (AI) pipeline for the reconstruction of the tooth-centric radial plane. By emulating expert's workflow, this AI pipeline acquires the optimized maxillary and mandibular cross sections, segments the teeth for dental arch curve depiction, and reconstructs dental arch-defined tooth-centric radial planes. A total of 420 CBCT scans from two independent centers, comprising both healthy and diseased subjects, were collected for model development and validation. Teeth on the optimized cross sections were explicitly segmented even in the presence of various complex diseases, resulting in precise dental arch curve depictions. The AI-reconstructed tooth-centric radial planes for all teeth exhibited low angular and distance errors compared with the ground truth planes. In terms of clinical utility, the AI-reconstructed planes demonstrated high image quality, accurately represented anatomical and pathological features, and facilitated precise dental biometrics measurement by both clinicians and downstream AI diagnostic tools. The expertise-inspired AI pipeline showcases outstanding performance in reconstructing tooth-centric radial planes and offers significant clinical utility for intelligent oral health management with high interpretability, robustness and generalization capabilities.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead-free transparent nanocomposite for efficient clinical X-ray shielding","authors":"Xiangzhou Zhang,&nbsp;Yeqi Liu,&nbsp;Xiaojia Wang,&nbsp;Nik Ahmad Nizam Nik Malek,&nbsp;Wan Hairul Anuar Kamaruddin,&nbsp;Liang-Jin Xu,&nbsp;Yaxing Wang,&nbsp;Zhaolai Chen,&nbsp;Yuhai Zhang","doi":"10.1002/bmm2.70008","DOIUrl":"https://doi.org/10.1002/bmm2.70008","url":null,"abstract":"<p>The increasing use of X-ray imaging in the medical field has generated a growing need for efficient shielding materials to protect healthcare personnel, especially those interventional surgeons, from radiation exposure risks. Conventional lead-based materials suffer from a high bio-toxicity and low transparency, which hinders their application in interventional surgeries. Herein, we report a lead-free nanocomposite of LaF₃ particles and poly(vinyl alcohol). Due to the low refractive-index contrast, the monolayer composite exhibits a high optical transparency of up to 86% in the visible light region with a fluoride-ceramic content of up to ∼70 wt%. Importantly, the transparency of the composite remains at 81% after stacking up 23 monolayers in a layer-by-layer manner. Due to the characteristic K-edge absorption of lanthanide element, the heavy-loading nanocomposite has showcased an effective X-ray attenuation ability (<i>μ</i> = 46.1 cm⁻¹ @ 50 kV) in the clinical range, which is 2.3 times that of the reported Pb-based glass. The shielding performance is further tested in a real clinical scenario, showing a 66% blocking efficacy for an 80-keV X-ray source. Our work provides an efficient approach for developing the next generation of biocompatible and transparent radiation shielding materials, which could benefit personal protection in fields involving interventional surgery, space-suit design, and the nuclear industry.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aminated graphene nanosheet stimulates the maturation of hiPSCs-derived cardiomyocytes in vitro and enhances their survival in vivo","authors":"Yin Xu,&nbsp;Xvdong Wang,&nbsp;Zihao Wang,&nbsp;Qi Chen,&nbsp;Donghui Zhang,&nbsp;Nianguo Dong,&nbsp;Jianglin Wang","doi":"10.1002/bmm2.70005","DOIUrl":"https://doi.org/10.1002/bmm2.70005","url":null,"abstract":"<p>Graphene-mediated niches with excellent electroconductibility, good flexibility and convenient modification play a central role in manipulating the cardiogenesis of stem cells. Herein, the graphene derivative matrix of aminated graphene (G-NH₂) was synthesized as a substrate niche to modulate cardiac differentiation of human induced pluripotent stem cells (hiPSCs). The conductivity of G-NH₂ matrix was close to that of native myocardium while the surface roughness of G-NH₂ matrix was much low to present a suitable interface for the adhesion of hiPSCs. The G-NH₂ matrix effectively elevated the maturation of hiPSCs-derived cardiomyocytes based on the evaluation of cardiomyocyte contraction, sarcomere patterns and length, and the content of NCAD (N-cadherin). The molecular mechanism of cardiomyocyte maturation was highly associated with the signaling pathway of PDGF-β. The mature cardiomyocytes derived from G-NH₂ were transplanted into the groin of immunodeficient mice to reveal the better survival and rapid angiogenesis. More importantly, in situ injection into rat hearts of differentiated mature cardiomyocytes exhibited the better performance on residence, survival and proliferation. Consequently, we created an instructive stem cell niche of G-NH₂ matrix that can electrically stimulate various cellular behaviors of hiPSCs in vitro, and the enhanced maturation of hiPSCs-cardiomyocytes manifests favorable activity and function in vivo.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweat-powered, skin-adhesive multimodal sensor for long-term and real-time sweat monitoring (1/2025)","authors":"Xinxin He,&nbsp;Zhiyuan Li,&nbsp;Xingcan Huang,&nbsp;Qiang Zhang,&nbsp;Yuyang Zeng,&nbsp;Jialin Li,&nbsp;Chun Ki Yiu,&nbsp;Yawen Yang,&nbsp;Jingkun Zhou,&nbsp;Guoqiang Xu,&nbsp;Jiachen Wang,&nbsp;Jian Li,&nbsp;Zitong Xu,&nbsp;Zhenlin Chen,&nbsp;Yiming Liu,&nbsp;Yuyu Gao,&nbsp;Binbin Zhang,&nbsp;Guangyao Zhao,&nbsp;Zhan Gao,&nbsp;Pengcheng Wu,&nbsp;Rui Shi,&nbsp;Yuze Qiu,&nbsp;Hehua Zhang,&nbsp;Lung Chow,&nbsp;Denglin Ye,&nbsp;Ya Huang,&nbsp;Xinge Yu","doi":"10.1002/bmm2.70007","DOIUrl":"https://doi.org/10.1002/bmm2.70007","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12124, Xinxin He, Zhiyuan Li, Xingcan Huang, Qiang Zhang, Yuyang Zeng and their co-workers developed a novel multimodal sweat monitoring device, which operates on a sweat-activated battery, can continuously and real-time monitor sweat for pH values, glucose concentration, and chloride ion levels. It seamlessly integrates colorimetric and electrochemical sensors, storing and transmitting data wirelessly via NFC. This enables users to access and analyze health data through their smartphones, enhancing the precision and convenience of long-term health monitoring. The research also explores advancements in sensor adhesion and stability, crucial for improving accuracy and wearer comfort, and discusses the ongoing challenges and future prospects in the field of personalized health monitoring.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic metabolism modulator for glycolytic intervention-induced cascade cancer therapy (1/2025)","authors":"Jiao Zheng,&nbsp;Jian Zhang,&nbsp;Tian Zhang,&nbsp;Yongcun Yan,&nbsp;Sai Bi","doi":"10.1002/bmm2.70006","DOIUrl":"https://doi.org/10.1002/bmm2.70006","url":null,"abstract":"<p>In this article number 10.1002/bmm2.12125, Jiao Zheng, Jian Zhang and their co-workers developed an automatic metabolism modulator (auto-MMOD) to intervene in the mitochondrial glycolysis process for cascade antitumor therapy. In the engineered auto-MMOD, the co-encapsulated glucose oxidase (GOx) and DNA-silver nanoclusters (DNA-AgNCs) successfully activates the glycolytic intervention-induced release of Ag+, thereby enhancing tumor inhibition and providing the valuable insight into a biological metabolism-mediated antitumor strategy.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood clot inspired pore-gradient nanofiber sponge with “outer filtration” and “inner adsorption” bifunction for rapid stop of uncontrolled hemorrhage","authors":"Fujin Zhou,&nbsp;Yong Yang,&nbsp;Yixuan Li,&nbsp;Ruolin Cao,&nbsp;Zheng Chen,&nbsp;Zhi Wang,&nbsp;Naiwen Tan,&nbsp;Lei Tian,&nbsp;Botao Song","doi":"10.1002/bmm2.70002","DOIUrl":"https://doi.org/10.1002/bmm2.70002","url":null,"abstract":"<p>Effectively controlling deep non-compressible bleeding remains a major challenge. In this study, by mimicking nanofiber structure and netting blood cells function of fibrin network in blood clots, we develop a novel bioinspired quaternized chitosan nanofiber sponge with distinct blood cells filtration and blood plasma absorption bifunction for rapid hemostasis. The quaternized chitosan nanofiber sponge possesses a unique gradient pore structure with small pores on the outer surface and large pores in the inner part. The outer small pores effectively capture blood cells with a filtration efficiency as high as 91.7%, while the inner large pores endow with an ultrahigh liquid absorption capacity (93 g/g), surpassing previously reported literature records. The quaternized chitosan nanofiber sponge demonstrates a hemostasis time 2.5 times faster than that of the commercial gelatin® hemostatic sponge when treating the rat liver defect bleeding (noncompressible hemorrhage model). When applied to the rabbit arterial injury bleeding (lethal arterial hemorrhage model), the bioinspired nanofiber sponge achieves bleeding control within only 61.6 s, while both commercial gelatin® hemostatic sponge and commercial collagen® hemostatic sponge fail to stop bleeding even after 240 s. This bioinspired nanofiber sponge derived from the physiological coagulation process may hold great potential for pre-hospital and battlefield first aid.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing next-generation immune cell therapies with nanomaterials","authors":"Kangfu Chen,&nbsp;Wenhan Wang,&nbsp;Zongjie Wang","doi":"10.1002/bmm2.70003","DOIUrl":"https://doi.org/10.1002/bmm2.70003","url":null,"abstract":"<p>Immune Cellular Therapies (ICT) have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors. Despite these successes, ICT faces significant challenges, including tumor accessibility, lengthy manufacturing turnaround, and limited long-term effectiveness. Recent advancements in nanomaterials, particularly nanoparticles, have offered promising solutions to these issues. This perspective introduces the current ICT manufacturing pipeline with a focus on solid tumors and showcases recent nanomaterial-mediated practices to enhance ICT. These efforts include the use of cell-targeting magnetic nanoparticles for non-invasive target identification, lipid nanoparticles for in vivo immune cell stimulation, as well as nanoparticle-mediated gene editing and cytokine delivery to enhance immune cell fitness. By better integrating nanoparticles into the design and manufacturing pipelines, we envision that the next generation of ICT could be faster, more efficient, and capable of targeting a broad spectrum of cancers and inflammatory diseases.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-cultured BMSC exosomes improve cerebral ischemia/reperfusion injury-induced neuronal apoptosis by regulating the microglia polarization","authors":"Yuming Li,&nbsp;Hao Shang,&nbsp;Qiong Zhang,&nbsp;Xianyong Yin,&nbsp;Zihao Liu,&nbsp;Yuqing Fang,&nbsp;Kyubae Lee,&nbsp;Huayang Zhao,&nbsp;Zhihai Wang,&nbsp;Hongbo Zhao,&nbsp;Xiaofeng Wang,&nbsp;Shengjie Li,&nbsp;Shan Wang,&nbsp;Tao Xin","doi":"10.1002/bmm2.70000","DOIUrl":"https://doi.org/10.1002/bmm2.70000","url":null,"abstract":"<p>Microglial activation is a key driver of neuroinflammation following cerebral ischemic reperfusion injury (CIRI). Exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) can regulate microglia, causing a transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, thereby reducing neuronal apoptosis in post-reperfusion injuries. However, the generation of superior-quality exosomes remains a significant hurdle in this field. We performed three-dimensional (3D) cultivation of BMSCs using a gelatin methacryloyl (GelMA) hydrogel and collected the released exosomes. We conducted experiments using lipopolysaccharide (LPS)-induced BV2 cells, oxygen-glucose deprivation/reoxygenation (OGD/R)- induced HT22 cells, and CIRI mice to verify the effects of 3D-cultured exosomes in regulating microglial activation and alleviating neuronal apoptosis. Based on the cellular and animal experiments, we successfully demonstrated the remarkable efficacy of exosomes derived from 3D-cultured BMSC using a GelMA hydrogel in the context of CIRI. These exosomes effectively mitigated the conversion of microglia to the inflammatory phenotype and facilitated their transition to the anti-inflammatory phenotype, thereby reducing aseptic inflammatory reactions and neuronal apoptosis. This study demonstrated the effectiveness of GelMA-based 3D-cultured exosomes in treating CIRI and introduced innovative concepts and opportunities for addressing this condition with clinical applications.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the skeletal interoceptive circuitry to control bone homeostasis","authors":"Yefeng Wu,&nbsp;Jiusi Guo,&nbsp;Zhen Chen,&nbsp;Fengwei Zhang,&nbsp;Billy Kwok Chong Chow,&nbsp;Zhuofan Chen,&nbsp;Kelvin Wai-Kwok Yeung,&nbsp;Wei Qiao","doi":"10.1002/bmm2.12138","DOIUrl":"https://doi.org/10.1002/bmm2.12138","url":null,"abstract":"<p>Bone tissue is richly innervated, and the influence of the nervous system on the physiological and pathological status of bone tissue has emerged as a significant research focus. The recent discovery of the skeletal interoceptive circuits further emphasizes the crucial role of the central nervous system in the control of bone homeostasis. Skeletal interoception represents one of the most intricate mechanisms in the human body for maintaining bone homeostasis, as it involves the orchestrated efforts of skeletal, nervous, immune, and endocrine systems. In this review, we comprehensively introduce the three primary components of the skeletal interoceptive circuitry, including the ascending pathways that perceive and convey signals to the central nervous system, the central neural pathways that process and interpret these signals, and the descending pathways that mediate the regulatory effects on bone tissue. We also discuss how innovative therapeutic strategies can be developed to modulate bone homeostasis by leveraging the most updated findings on skeletal interoceptive circuitry. We anticipate that the application of knowledge on skeletal interoception will lead to a paradigm shift in the field of orthopaedics and biomaterials.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}