BMEMat Pub Date : 2023-09-26 DOI: 10.1002/bmm2.12048

Hayoung Song, Moohyun Kim, Enji Kim, Jakyoung Lee, Inhea Jeong, Kyeonghee Lim, Seoung Young Ryu, Myoungjae Oh, Younhee Kim, Jang-Ung Park

{"title":"Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments","authors":"Hayoung Song, Moohyun Kim, Enji Kim, Jakyoung Lee, Inhea Jeong, Kyeonghee Lim, Seoung Young Ryu, Myoungjae Oh, Younhee Kim, Jang-Ung Park","doi":"10.1002/bmm2.12048","DOIUrl":"10.1002/bmm2.12048","url":null,"abstract":"The peripheral nervous system (PNS) is a fascinatingly complex and crucial component of the human body, responsible for transmitting vital signals throughout the body's intricate network of nerves. Its efficient functioning is paramount to our health, with any dysfunction often resulting in serious medical conditions, including motor disorders, neurological diseases, and psychiatric disorders. Recent strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health issues. Neuromodulation involves modifying nerve activity using a range of techniques, such as electrical, chemical, optical, and mechanical stimulation. Bioelectronics plays a critical role in this effort, allowing for precise, controlled, and sustained stimulation of the PNS. This paper provides an overview of the PNS, discusses the current state of neuromodulation devices, and presents emerging trends in the field, including advances in wireless power transfer and materials, that are shaping the future of neuromodulation.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy 用于增强癌症催化治疗的多金属基纳米酶的最新进展

BMEMat Pub Date : 2023-09-19 DOI: 10.1002/bmm2.12043

Mingjin Cui, Bo Xu, Lianhui Wang

{"title":"Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy","authors":"Mingjin Cui, Bo Xu, Lianhui Wang","doi":"10.1002/bmm2.12043","DOIUrl":"10.1002/bmm2.12043","url":null,"abstract":"Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing natural enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest and exploration in the utilization of nanozymes for targeted cancer treatment. Recent advancements in interdisciplinary research, nanotechnology, biotechnology, and catalytic technology have led to the emergence of multi-metallic-based nanozymes, which exhibit tremendous potential for further development. This review focuses on investigating the synergistic effects of multi-metallic-based nanozymes, aiming to enhance our understanding of their catalytic activities and facilitate their broader applications. We comprehensively survey the remarkable achievements in the synthesis, catalytic mechanisms, and the latest applications of multi-metallic-based nanozymes in cancer catalytic therapy. Furthermore, we identify the current limitations and prospects of multi-metallic-based nanozymes in the development of new materials and the application of novel technologies, along with the potential challenges associated with catalytic cancer therapy. This review underscores the significance of multi-metallic-based nanozymes and emphasizes the need for continued exploration as well as their potential impact on the development of novel materials and the realization of breakthroughs in catalytic tumor therapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135015258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in sensor developments for cell culture monitoring 用于细胞培养监测的传感器开发进展

BMEMat Pub Date : 2023-09-19 DOI: 10.1002/bmm2.12047

Ka Ram Kim, Woon-Hong Yeo

引用次数: 1

Review on carbon dots: Synthesis and application in biology field 碳点综述：合成及在生物领域的应用

BMEMat Pub Date : 2023-09-08 DOI: 10.1002/bmm2.12045

Xueting Li, Lidong Yu, Mingyue He, Ce Chen, Zewen Yu, Shanshan Jiang, Yi Wang, Li Li, Bingsheng Li, Guixue Wang, Aidong Shen, Jianglin Fan

{"title":"Review on carbon dots: Synthesis and application in biology field","authors":"Xueting Li, Lidong Yu, Mingyue He, Ce Chen, Zewen Yu, Shanshan Jiang, Yi Wang, Li Li, Bingsheng Li, Guixue Wang, Aidong Shen, Jianglin Fan","doi":"10.1002/bmm2.12045","DOIUrl":"10.1002/bmm2.12045","url":null,"abstract":"As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size, stable chemical properties, excellent photoluminescence characteristics, but also exhibit good biocompatibility and low toxicity. It has attracted considerable attention in the field of nanotechnology and biological science. CDs contain abundant functional groups on the surface, which not only retain part of the properties of raw materials, but also may have new photoelectric, catalytic, biomedical, and other functions. In this review, we systematically summarize the synthesis methods, modifications, optical properties, and main biological functions of CDs in recent years. The application of functionalized modified CDs in biological detection, biological imaging, photodynamic therapy, photothermal therapy, targeted therapy, drug delivery, gene delivery, protein delivery, and other biomedical fields is introduced. The latest progress of CDs with its own biomedical function in antioxidant, anti-pathogen, and disease treatment is summarized. Finally, we discuss some problems in the practical application of CDs and look forward to the future development trend of self-functional CDs combined with surface modification to achieve multimodal treatment of diseases.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88845060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced strategies of scaffolds design for bone regeneration 骨再生支架设计的先进策略

BMEMat Pub Date : 2023-09-02 DOI: 10.1002/bmm2.12046

Jian Song, Longfei Li, Lei Fang, Enshuo Zhang, Yu Zhang, Zhuxuan Zhang, Pranav Vangari, Yaqin Huang, Feng Tian, Yu Zhao, Wei Chen, Jiajia Xue

引用次数: 4

The progress of fabrication designs of polymeric microneedles and related biomedical applications 聚合物微针的制造设计进展及相关生物医学应用

BMEMat Pub Date : 2023-08-29 DOI: 10.1002/bmm2.12044

Xue Jiang, Wen Zhang, Richard Terry, Wei Li

引用次数: 1

Recent advancements in biomedical application of polylactic acid/graphene nanocomposites: An overview 聚乳酸/石墨烯纳米复合材料在生物医学应用方面的最新进展：综述

BMEMat Pub Date : 2023-08-21 DOI: 10.1002/bmm2.12042

Gbolahan Joseph Adekoya, Anthony Chidi Ezika, Oluwasegun Chijioke Adekoya, Emmanuel Rotimi Sadiku, Yskandar Hamam, Suprakas Sinha Ray

{"title":"Recent advancements in biomedical application of polylactic acid/graphene nanocomposites: An overview","authors":"Gbolahan Joseph Adekoya, Anthony Chidi Ezika, Oluwasegun Chijioke Adekoya, Emmanuel Rotimi Sadiku, Yskandar Hamam, Suprakas Sinha Ray","doi":"10.1002/bmm2.12042","DOIUrl":"10.1002/bmm2.12042","url":null,"abstract":"Polylactic acid (PLA)-graphene nanocomposites have attracted significant attention in the biomedical field because of their biodegradability, biocompatibility, and excellent mechanical properties. This review provides a comprehensive summary of the recent developments in the biomedical applications of PLA/graphene nanocomposites. The discussed applications include tissue engineering, drug delivery, biomedical imaging and sensing, antimicrobial and anticancer treatments, and photothermal and photodynamic therapies. The properties and synthesis of these nanocomposites are also addressed. This review shows that although significant advancements have been made in the development of biomedical applications for PLA/graphene nanocomposites, further research is still required to overcome the existing challenges and limitations, such as improving biocompatibility and biodegradability and optimizing synthesis and processing methods. Despite these challenges, the potential of PLA/graphene nanocomposites in the biomedical field is significant and holds promise for future advancements.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88548567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy 载入抗坏血酸钙的介孔聚多巴胺纳米平台用于放大氧化和光热联合癌症疗法

BMEMat Pub Date : 2023-08-11 DOI: 10.1002/bmm2.12041

Meng Zhang, Siyi Ran, Xueling Yin, Jiting Zhang, Xiao Sun, Wei Sun, Zhihong Zhu

{"title":"Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy","authors":"Meng Zhang, Siyi Ran, Xueling Yin, Jiting Zhang, Xiao Sun, Wei Sun, Zhihong Zhu","doi":"10.1002/bmm2.12041","DOIUrl":"10.1002/bmm2.12041","url":null,"abstract":"Destruction of cellular redox homeostasis to induce cancer cell apoptosis is an emerging tumor therapeutic strategy. To achieve this goal, elevating exogenous oxidative stress or impairing the antioxidant defense system of cancer cells is an effective method. Herein, we firstly report a biocompatible and versatile nanoplatform based on mesoporous polydopamine (MpDA) nanoparticles and a phase-change material (PCM) for delivering calcium ascorbate (Vc-Ca), simultaneously enabling combination therapy of hyperthermia, reactive oxygen species (ROS) generation, and suppression of tumor antioxidant capability. In this design, Vc-Ca encapsulated in MpDA using PCM is controllably released due to the melting of PCM matrix in response to photothermal heating upon near-infrared irradiation. Vc-Ca is proved to be a pro-oxidant that can promote the production of ROS (H2O2) in the tumor site. Remarkably, MpDA can not only act as a photothermal agent but also can break the redox balance of cancer cells through depleting the primary antioxidant glutathione, thus amplifying Vc-Ca-mediated oxidative therapy. Both in vitro and in vivo results demonstrate the significantly enhanced antitumor activity of boosted ROS combined with local hyperthermia. This study highlights the potential applications of Vc-Ca in cancer treatment, and the prepared multifunctional nanoplatform provides a novel paradigm for high-efficiency oxidation-photothermal therapy.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90581859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform 单细胞微流体平台实时筛选细胞因子研究氧化锌纳米棒阵列对乳腺癌症细胞的抑制作用

BMEMat Pub Date : 2023-08-11 DOI: 10.1002/bmm2.12040

Ping Li, Chao Wang, Jiaoyan Qiu, Fangteng Song, Yuzhen Huang, Yunhong Zhang, Kai Zhang, Hao Ji, Yuanhua Sang, Jonny J. Blaker, Yu Zhang, Lin Han

{"title":"Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform","authors":"Ping Li, Chao Wang, Jiaoyan Qiu, Fangteng Song, Yuzhen Huang, Yunhong Zhang, Kai Zhang, Hao Ji, Yuanhua Sang, Jonny J. Blaker, Yu Zhang, Lin Han","doi":"10.1002/bmm2.12040","DOIUrl":"https://doi.org/10.1002/bmm2.12040","url":null,"abstract":"Zinc oxide nanorods have been extensively studied for the specific killing of breast cancer (BC) cells, and their killing mechanism and anticancer effects have been initially demonstrated. However, systematic studies at the single-cell level are still necessary to explore cellular functions in detail. In this work, a hydrothermal method was used to synthesize zinc oxide nanorod arrays (ZnO NRs). Their effect on BC cells was demonstrated at single-cell resolution for the first time through microfluidic chips and a single-cell analysis platform. The inhibitory effects of ZnO NRs were observed. First, ZnO NRs suppressed cell proliferation and migration abilities. Moreover, Interferon-γ, Tumor Necrosis Factor-α, and Granzyme B in BC cells turned out to be antitumor instead of tumorigenic under ZnO NRs stimulation. Furthermore, ZnO NRs inhibition altered cellular functions and thus weakened intercellular and intercluster correlations. More importantly, MDA-MB-231 cells (strongly metastatic) showed much greater resistance to ZnO NRs than MCF-7 cells (nonmetastatic). The experiments complemented the findings at the single-cell level and provided a more comprehensive consideration of the potential risks and applications of ZnO NRs in breast cancer therapy, which is of great importance for biomedical research on nanomaterials.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50128197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biomaterials for in situ cell therapy 用于原位细胞治疗的生物材料

BMEMat Pub Date : 2023-07-19 DOI: 10.1002/bmm2.12039

Chang Wang, Siyu Wang, Diana D. Kang, Yizhou Dong

引用次数: 6

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