IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-06-21 DOI: 10.1002/bmm2.70013

Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang

{"title":"Layered double hydroxides-based nanozymes for effective biomedical applications: A review and future perspectives","authors":"Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang","doi":"10.1002/bmm2.70013","DOIUrl":"https://doi.org/10.1002/bmm2.70013","url":null,"abstract":"Nanozymes including noble metals, metal oxides, metal-organic frameworks, carbon-based nanomaterials, and layered double hydroxides (LDHs) have undergone rapid development in recent years. In addition to the cost-effectiveness, high stability, and superior catalytic capabilities of common nanozymes, LDHs have unique characteristics such as extensive surface area, anion exchange capacity, adjustable composition/structure, and low toxicity. Leveraging these properties, LDH-based nanozymes (LDHzymes) with enzyme-like activity demonstrate significant potential for applications, particularly in biomedicine. This review summarizes the preparation methods for LDHzymes with different morphology and elucidates their catalytic activities (including peroxidase-, oxidase-, superoxide dismutase-, and catalase-like activity) and mechanisms. Subsequently, the applications of LDHzymes across biomedical fields are examined, including biosensing and detection, antimicrobial properties, treatment of tumors, and reactive oxygen species-related diseases. Finally, future research directions for LDHzymes are proposed, including the design of high-performance LDHzymes, intelligent therapeutic applications, and the expansion of application fields, which provide a framework for the development of novel LDHzymes for biomedical applications.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional H2S-activated metal-organic framework systems for targeted colorectal cancer imaging and synergistic copper-induced tumor regression 多功能h2s激活的金属有机框架系统用于靶向结直肠癌成像和协同铜诱导的肿瘤消退

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-09-04 DOI: 10.1002/bmm2.70029

Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu

{"title":"Multifunctional H2S-activated metal-organic framework systems for targeted colorectal cancer imaging and synergistic copper-induced tumor regression","authors":"Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu","doi":"10.1002/bmm2.70029","DOIUrl":"https://doi.org/10.1002/bmm2.70029","url":null,"abstract":"Stimuli-responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics. Hydrogen sulfide (H2S) was found to be upregulated in colorectal cancer, which endows it with an ideal endogenous trigger for tumor targeting. Here, we introduce a novel class of H2S-activated metal-organic framework (MOF) systems specifically designed for targeted colorectal cancer imaging and synergistic copper-induced tumor regression. The Cu-MOF nanoplatform demonstrated a rapid response to H2S at the tumor site, producing copper sulfide with strong near infrared absorption and activated PA signals. In vivo studies demonstrated remarkable tumor inhibition in an orthotopic colon cancer model with minimal side effects. The copper-based MOFs theranostic nanosystem effectively reduced protein lipoylation and Fe-S cluster protein levels (FDX1), triggering cuproptosis. This study presents a novel strategy for designing multifunctional nanoparticles for synergistic PA/CDT/PTT/cuproptosis theranostics.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision modulation of tumor excitability: Targeting cell phenotypic heterogeneity for next-generation cancer therapy 肿瘤兴奋性的精确调节：针对下一代癌症治疗的细胞表型异质性

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2026-02-11 DOI: 10.1002/bmm2.70065

Zonghao Liu, Xingwu Jiang, Gang Liu, Jian Chen, Kun Song, Xu Li, Siew Yee Wong, Ruicheng Shi, Yanyan Liu, Wenbo Bu

{"title":"Precision modulation of tumor excitability: Targeting cell phenotypic heterogeneity for next-generation cancer therapy","authors":"Zonghao Liu, Xingwu Jiang, Gang Liu, Jian Chen, Kun Song, Xu Li, Siew Yee Wong, Ruicheng Shi, Yanyan Liu, Wenbo Bu","doi":"10.1002/bmm2.70065","DOIUrl":"https://doi.org/10.1002/bmm2.70065","url":null,"abstract":"Electrical excitability, long regarded as a defining property of neurons, is now increasingly recognized in cancer cells, particularly within phenotypically heterogeneous tumor subpopulations. A recent Nature study revealed that the neuroendocrine (NE) subpopulation of small cell lung cancer exhibits neuron-like excitability, capable of generating action potentials and forming intercellular signaling networks that enhance malignancy and metastasis. This discovery highlights how electrical excitability can arise in cancer cells through metabolic reprogramming and dynamic interactions within the tumor microenvironment. Moreover, heterogeneous tumor subpopulations may cooperate to sustain excitability via metabolic coupling. These findings challenge conventional views of tumor biology, establishing a new paradigm in which cancer heterogeneity drives electrophysiological diversity and functional plasticity, fundamentally reshaping our understanding of tumor behavior, communication, and progression.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers 后段眼病的纳米结构药物输送系统：克服眼屏障的策略

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-05-28 DOI: 10.1002/bmm2.70016

Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang

{"title":"Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers","authors":"Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang","doi":"10.1002/bmm2.70016","DOIUrl":"https://doi.org/10.1002/bmm2.70016","url":null,"abstract":"Posterior segment eye diseases (PSEDs) remain a leading cause of irreversible blindness, with the eye's dynamic and static barriers posing challenges to effective drug delivery through different administration routes. Currently, treatment options available for PSEDs are limited, with invasive intravitreal injection being the predominant choice. However, frequent injections carry a high risk of complications, and are associated with low patient compliance. The rapid advancement of nanomaterials has sparked intense interest in nanoconstructed drug delivery systems as potential solutions to overcome these bottlenecks. Experimental studies have demonstrated that diverse nanocarriers can accommodate different therapeutic agents and circumvent ocular barriers through multiple mechanisms, including prolonged drug residence, enhanced tissue permeability, to name a few. In addition, nanomaterial-based delivery systems also offer advantages in improving posterior segment drug delivery efficiency and therapeutic practicality. In this review, the multiple ocular barriers and traditional administration routes are presented first. Then, we focus on the promise held by nanoplatforms for barrier penetration and summarize key mechanisms involved. Meanwhile, the review highlights the value of nanocarriers in achieving efficient drug delivery and treatment of PSEDs with illustrative examples and tables. Finally, current challenges and future prospects are also discussed here to encourage basic research and clinical transformation.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional H2S-activated metal-organic framework systems for targeted colorectal cancer imaging and synergistic copper-induced tumor regression 多功能h2s激活的金属有机框架系统用于靶向结直肠癌成像和协同铜诱导的肿瘤消退

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-09-04 DOI: 10.1002/bmm2.70029

Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu

{"title":"Multifunctional H2S-activated metal-organic framework systems for targeted colorectal cancer imaging and synergistic copper-induced tumor regression","authors":"Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu","doi":"10.1002/bmm2.70029","DOIUrl":"https://doi.org/10.1002/bmm2.70029","url":null,"abstract":"Stimuli-responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics. Hydrogen sulfide (H2S) was found to be upregulated in colorectal cancer, which endows it with an ideal endogenous trigger for tumor targeting. Here, we introduce a novel class of H2S-activated metal-organic framework (MOF) systems specifically designed for targeted colorectal cancer imaging and synergistic copper-induced tumor regression. The Cu-MOF nanoplatform demonstrated a rapid response to H2S at the tumor site, producing copper sulfide with strong near infrared absorption and activated PA signals. In vivo studies demonstrated remarkable tumor inhibition in an orthotopic colon cancer model with minimal side effects. The copper-based MOFs theranostic nanosystem effectively reduced protein lipoylation and Fe-S cluster protein levels (FDX1), triggering cuproptosis. This study presents a novel strategy for designing multifunctional nanoparticles for synergistic PA/CDT/PTT/cuproptosis theranostics.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the skeletal interoceptive circuitry to control bone homeostasis (3/2025) 破解骨骼内感受回路控制骨骼稳态（3/2025）

IF 15.5

BMEMat Pub Date : 2025-09-25 DOI: 10.1002/bmm2.70036

Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai-Kwok Yeung, Wei Qiao

引用次数: 0

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities (3/2025) 揭示癌症细胞衰老的复杂性：从机制到治疗机会（3/2025）

IF 15.5

BMEMat Pub Date : 2025-09-25 DOI: 10.1002/bmm2.70037

Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu

引用次数: 0

Self-supervised denoising for medical imaging enhancement 医学影像增强的自监督去噪

IF 15.5

BMEMat Pub Date : 2025-06-30 DOI: 10.1002/bmm2.70018

Guoxun Zhang, Yuanyuan Wei, Ho-Pui Ho

{"title":"Self-supervised denoising for medical imaging enhancement","authors":"Guoxun Zhang, Yuanyuan Wei, Ho-Pui Ho","doi":"10.1002/bmm2.70018","DOIUrl":"https://doi.org/10.1002/bmm2.70018","url":null,"abstract":"Self-supervised denoising has emerged as a promising approach for enhancing the quality of medical imaging, particularly in modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and optical microscopy. Traditional supervised methods often require large datasets of paired noisy and clean images, which are challenging to acquire in clinical practice. In contrast, self-supervised strategies exploit the inherent redundancy and structure within the data itself, enabling effective noise reduction without the need for explicitly labeled training pairs. This Perspective synthesizes recent advances in self-supervised denoising techniques, outlining their underlying principles, algorithmic innovations, and practical applications across different imaging modalities. In MRI, these methods have been shown to improve contrast and detail resolution, while in CT, they contribute to reducing radiation dose by allowing lower signal acquisitions without compromising image quality. In optical microscopy, self-supervised denoising facilitates extracting high-fidelity cellular information from inherently low-light environments. Furthermore, these techniques have also proven effective in imaging of biomedical materials, such as tissue engineering scaffolds, drug delivery systems, and implants, improving the evaluation of their interactions with biological tissues. Collectively, the integration of these advanced denoising frameworks holds significant promise for improving diagnostic accuracy, streamlining clinical workflows, and ultimately enhancing patient outcomes.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"3 3","pages":""},"PeriodicalIF":15.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects (2/2025) 用于增强x射线引发的癌症治疗的纳米材料：进展和前景（2/2025）

BMEMat Pub Date : 2025-06-28 DOI: 10.1002/bmm2.70023

Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan

引用次数: 0

Liver organoids: From 3D printing to biomedical applications (2/2025) 类肝器官：从3D打印到生物医学应用（2/2025）

BMEMat Pub Date : 2025-06-28 DOI: 10.1002/bmm2.70024

Ying Shi, Xin Han, Zheng Zhang, Jiangtao Xu, Guozhen Liu

引用次数: 0

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