IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-05-14 DOI: 10.1002/bmm2.70014

Ruyue Li, Bo Liu, Cheng Wang, Zhencheng Sun, Shuyi Lv, Liang Tian, Minghui Xiao, Qinyang Zheng, Linqi Shi, Chunlei Zhu

{"title":"A pH-responsive charge-reversal liposome with enhanced biofilm penetration for multimodal synergistic therapy of bacterial infections","authors":"Ruyue Li, Bo Liu, Cheng Wang, Zhencheng Sun, Shuyi Lv, Liang Tian, Minghui Xiao, Qinyang Zheng, Linqi Shi, Chunlei Zhu","doi":"10.1002/bmm2.70014","DOIUrl":"10.1002/bmm2.70014","url":null,"abstract":"Biofilm infections pose a significant clinical challenge largely due to the limited penetration of a variety of antibacterial agents, making traditional antibiotic therapies ineffective. In this study, we develop a pH-responsive, charge-reversal liposomal system (TPA-ICN/LVF@Lipo-PyB) loaded with the phototherapeutic agent TPA-ICN and the antibiotic levofloxacin (LVF) for multimodal synergistic therapy of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections. The surface-grafted pyridine betaine group enables charge reversal of TPA-ICN/LVF@Lipo-PyB through rapid and efficient protonation to enhance its penetration capability in the acidic microenvironment of biofilms. Upon laser irradiation, the liposomal system exhibits both photodynamic and photothermal properties to inactivate bacteria within the biofilm. Simultaneously, the photothermal effect effectively disassembles the liposome due to the presence of thermosensitive phospholipids to trigger LVF release, ensuring the effective eradication of residual bacteria. Remarkably, the multimodal synergistic therapy demonstrates exceptional in vitro bacterial eradication, achieving a 99.99% reduction in MRSA biofilms. Furthermore, TPA-ICN/LVF@Lipo-PyB significantly accelerates the healing of MRSA-infected wounds by reducing inflammation, promoting angiogenesis, and enhancing collagen regeneration. These outstanding therapeutic results highlight the potential of this approach for the safe and effective clinical management of wound infections.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair HAp@MXene纳米复合材料程序性调控巨噬细胞极化促进骨修复

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-09-18 DOI: 10.1002/bmm2.70034

Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu

{"title":"Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair","authors":"Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu","doi":"10.1002/bmm2.70034","DOIUrl":"10.1002/bmm2.70034","url":null,"abstract":"Patients with large-area bone defects are highly prone to infection, which significantly hinders healing. This study presents an innovative strategy that combines exogenous physical signals with implantable materials to achieve programmed immune modulation by dynamically regulating macrophage M1/M2 polarization, striking a balance between antibacterial activity and bone regeneration. Specifically, we synthesized HAp@MXene nanocomposites by integrating hydroxyapatite nanorods with MXene nanosheets, resulting in multifunctional materials with unique magnetoelectric properties and controlled Ca2+ release. These nanocomposites exert their effects through cellular internalization, where magnetoelectric induction generates intracellular currents to promote macrophage M1 polarization, initiating a pro-inflammatory response to mitigate infection risk. Subsequently, calcium ions are released within lysosomes, driving macrophage M2 polarization to facilitate anti-inflammatory response and promote tissue regeneration. This dual-modality mechanism achieves the precise programmatic regulation of macrophages, accelerates and optimizes the process of bone defect repair, and underscores the immense potential of HAp@MXene nanocomposites in synergistic antibacterial and bone regeneration therapies.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D bioprinting in oral and craniomaxillofacial tissue regeneration: Progress, challenges, and future directions 3D生物打印在口腔和颅颌面组织再生中的应用：进展、挑战和未来方向

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-08-19 DOI: 10.1002/bmm2.70027

Huilu Zhan, Haohao Ni, Xingge Yu, Mazaher Gholipourmalekabadi, Tianqi Wang, Kaili Lin, Jinsong Pan, Changyong Yuan

{"title":"3D bioprinting in oral and craniomaxillofacial tissue regeneration: Progress, challenges, and future directions","authors":"Huilu Zhan, Haohao Ni, Xingge Yu, Mazaher Gholipourmalekabadi, Tianqi Wang, Kaili Lin, Jinsong Pan, Changyong Yuan","doi":"10.1002/bmm2.70027","DOIUrl":"10.1002/bmm2.70027","url":null,"abstract":"Oral and craniomaxillofacial tissues are essential for maintaining oral functions, including respiration, mastication, swallowing, and speech. They also play a pivotal role in facial aesthetics and overall health. However, the intricate anatomy, co-existence of diverse tissue types, and high demand for functional recovery make regeneration a challenging process. Traditional 3D printing technology is limited to fulfilling morphological requirements and cannot meet the complex demands of multi-tissue regeneration and functional restoration in the oral and craniomaxillofacial regions. In contrast, 3D bioprinting technology enables the creation of biologically functional cell-laden living scaffolds that are highly compatible with defect sites. This advanced approach effectively promotes post-transplantation tissue integration and significantly enhances therapeutic outcomes. This review focuses on the utilization of 3D bioprinting in oral and craniomaxillofacial tissue regeneration. It highlights advancements in biomaterial application and printing technology, and current achievements and challenges in preclinical and clinical research, aiming to facilitate the translational and innovative applications of this technology in oral and craniomaxillofacial repair and reconstruction.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ biomimetic materials for dentin repair 牙本质原位修复仿生材料

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-04-30 DOI: 10.1002/bmm2.70009

Jingjing Deng, Siyi Ren, Xuliang Deng, Yan Wei

{"title":"In situ biomimetic materials for dentin repair","authors":"Jingjing Deng, Siyi Ren, Xuliang Deng, Yan Wei","doi":"10.1002/bmm2.70009","DOIUrl":"10.1002/bmm2.70009","url":null,"abstract":"Dental defects, ranking among the most prevalent diseases globally, pose a serious threat to human health, with extensive defects involving dentin leading to complications such as pulp and periodontal diseases, as well as maxillofacial dysfunctions, significantly impairing quality of life. Current clinical treatments primarily rely on rigid materials such as metals, composite resins, and ceramics for macroscopic filling. However, their inherent limitations, differences in compositional and structural characteristics from natural dentin, mismatched mechanical properties, and interfacial adhesion instability, fail to meet the clinical demand for long-term and stable restoration of natural dentin. In situ dentin regeneration, inspired by the complex composition and hierarchical structure of natural dentin, aims to induce the autonomous repair of dentin. This approach effectively overcomes the traditional limitations, shifting from traditional passive filling to active regenerative repair. Based on the growth direction and mineralization pattern of the repair layer, current research focuses on three strategies: “inward growth”, “outward growth”, and “synchronized inward-outward growth”. This review primarily focuses on the roles and clinical applications of key bioactive materials in these strategies, providing a feasible basis for future material and performance optimization of dentin in situ regeneration.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing biophysical properties of cellular niches to enhance stem cell-derived extracellular vesicle function in musculoskeletal regeneration 优化细胞壁龛的生物物理特性以增强干细胞来源的细胞外囊泡在肌肉骨骼再生中的功能

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-05-27 DOI: 10.1002/bmm2.70012

Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang

{"title":"Optimizing biophysical properties of cellular niches to enhance stem cell-derived extracellular vesicle function in musculoskeletal regeneration","authors":"Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang","doi":"10.1002/bmm2.70012","DOIUrl":"10.1002/bmm2.70012","url":null,"abstract":"Extracellular vesicles (EVs) secreted by stem cells have become a promising cell-free approach in regenerative medicine, with significant potential for the repair and treatment of musculoskeletal tissues and disorders. However, the limited bioactivity and scalability of EV production pose significant challenges for commercial production and clinical translation. To overcome these challenges, researchers have started exploring how the cellular microenvironment can modulate EV characteristics and enhance their therapeutic efficacy. While the microenvironment's biochemical facets have been the primary focus of prior investigations, the influence of biophysical factors on EV characteristics remains relatively underexplored. This review consolidates the existing research investigating the effects of biophysical features of the cellular microenvironment on EV production and function, with a particular emphasis on applications in musculoskeletal regeneration. By providing a comprehensive understanding of how biophysical factors impact EVs, this review seeks to enhance the development of effective strategies that harness the power of EVs for large-scale production and their successful application in regenerative therapies for musculoskeletal disorders. Ultimately, such insights could greatly assist patients who require innovative, cell-free regenerative treatments, thereby propelling advancements in musculoskeletal tissue engineering and in regenerative medicine.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis 外泌体作为生物活性纳米囊泡在牙周炎诊断和治疗中的应用

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-06-04 DOI: 10.1002/bmm2.70017

Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han

{"title":"Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis","authors":"Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han","doi":"10.1002/bmm2.70017","DOIUrl":"10.1002/bmm2.70017","url":null,"abstract":"Periodontitis is a common and frequent oral disease which is characterized by persistent loss of periodontal supportive tissue and seriously affects the physical and psychological health. Existing clinical diagnostic indicators are incapable of accurately diagnosing periodontitis patients at an early stage, while traditional treatment methods are unable to promote the periodontal bone regeneration stably. It is vital to explore more sensitive methods for aided diagnosis and precise treatment to improve clinical efficacy. Exosomes are nano-sized extracellular vesicles that are produced by all kinds of cells. In recent years, many studies have revealed that exosomes are abundant in complex biogenetic materials that participate in cell signaling, immunomodulation, and tissue regeneration. Furthermore, their enormous potential in disease diagnosis and treatment is gradually explored. Here, we review the current impact of exosomes on the development and progression of periodontitis. We briefly describe some studies that discovered that the amount and component of exosomes are altered during the pathogenesis of periodontitis, demonstrating their potential as indicators for aided diagnosis. We also categorize the application of various cell and plant-derived exosomes, as well as the research progress of some novel engineered exosomes, which provides some new directions for designing personalized therapeutic strategies for periodontitis patients.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond 糖尿病伤口护理的前沿策略：纳米技术、生物工程等

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-09-30 DOI: 10.1002/bmm2.70033

Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra

{"title":"Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond","authors":"Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra","doi":"10.1002/bmm2.70033","DOIUrl":"10.1002/bmm2.70033","url":null,"abstract":"Diabetic wounds affect millions of people globally, posing significant clinical and socioeconomic challenges due to their prolonged healing times and risk of complications. This review provides a comprehensive examination of the pathophysiology underlying delayed wound healing in patients with diabetes, focusing on key mechanisms such as hyperglycemia, oxidative stress, vascular insufficiency, and chronic inflammation. Impairments in angiogenesis, growth factor signaling, and tissue regeneration create a complex therapeutic landscape that demands multifaceted approaches. Accordingly, this review critically examines current clinical interventions such as topical growth factors, antioxidant therapies, and hyperbaric oxygen. Furthermore, it explores innovative solutions, such as advanced wound dressings, bioengineered materials, and stem cell therapy, which offer enhanced wound healing outcomes. We provided a comprehensive analysis of innovative platforms, such as nanoparticle-loaded hydrogels and 3D printing, shedding light on their transformative potential to revolutionize wound care through personalized multifunctional therapies. This review concludes by identifying critical gaps and proposing a roadmap for future research and clinical innovations to enhance diabetic wound management and improve patient outcomes.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers 后段眼病的纳米结构药物输送系统：克服眼屏障的策略

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-05-28 DOI: 10.1002/bmm2.70016

Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang

{"title":"Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers","authors":"Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang","doi":"10.1002/bmm2.70016","DOIUrl":"https://doi.org/10.1002/bmm2.70016","url":null,"abstract":"Posterior segment eye diseases (PSEDs) remain a leading cause of irreversible blindness, with the eye's dynamic and static barriers posing challenges to effective drug delivery through different administration routes. Currently, treatment options available for PSEDs are limited, with invasive intravitreal injection being the predominant choice. However, frequent injections carry a high risk of complications, and are associated with low patient compliance. The rapid advancement of nanomaterials has sparked intense interest in nanoconstructed drug delivery systems as potential solutions to overcome these bottlenecks. Experimental studies have demonstrated that diverse nanocarriers can accommodate different therapeutic agents and circumvent ocular barriers through multiple mechanisms, including prolonged drug residence, enhanced tissue permeability, to name a few. In addition, nanomaterial-based delivery systems also offer advantages in improving posterior segment drug delivery efficiency and therapeutic practicality. In this review, the multiple ocular barriers and traditional administration routes are presented first. Then, we focus on the promise held by nanoplatforms for barrier penetration and summarize key mechanisms involved. Meanwhile, the review highlights the value of nanocarriers in achieving efficient drug delivery and treatment of PSEDs with illustrative examples and tables. Finally, current challenges and future prospects are also discussed here to encourage basic research and clinical transformation.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A targeted antiferromagnetic nanoprobe for ultra-sensitive magnetic resonance imaging detection of sub-millimeter esophageal tumors 一种靶向反铁磁纳米探针用于亚毫米级食道肿瘤的超灵敏磁共振成像检测

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-10-25 DOI: 10.1002/bmm2.70040

Wenkui Mo, Zeyu Liang, Bo Zhang, Lin Xiao, Xun Liu, Zhigao Yi, Shangzhi Xie, Qiyue Wang, Liang Shi, Taobo Luo, Feng Li, Leilei Wu, Yuanzhe Piao, Fangyuan Li, Jian Zeng, Daishun Ling

{"title":"A targeted antiferromagnetic nanoprobe for ultra-sensitive magnetic resonance imaging detection of sub-millimeter esophageal tumors","authors":"Wenkui Mo, Zeyu Liang, Bo Zhang, Lin Xiao, Xun Liu, Zhigao Yi, Shangzhi Xie, Qiyue Wang, Liang Shi, Taobo Luo, Feng Li, Leilei Wu, Yuanzhe Piao, Fangyuan Li, Jian Zeng, Daishun Ling","doi":"10.1002/bmm2.70040","DOIUrl":"10.1002/bmm2.70040","url":null,"abstract":"Early, non-invasive detection of esophageal cancer at sub-millimeter resolution is critical for tailoring precise therapeutic strategies. While ultra-high-field (UHF) magnetic resonance imaging (MRI) offers exceptional spatial resolution, the lack of optimized contrast agents capable of enhancing sensitivity for detecting microscopic tumors remains a significant challenge. Here, we report a cyclo-RGD peptide-conjugated antiferromagnetic nanoparticle (RANP) as a novel targeted T1 contrast agent, specifically designed to improve in vivo imaging of esophageal tumors at the micrometer scale. The RANP integrates an antiferromagnetic core with low magnetization, minimizing T2 decaying effects, while the cyclo-RGD peptide enhances its targeting ability by specifically binding to integrin αvβ3, a biomarker highly expressed on tumor vasculature. This targeted conjugation improves the probe's selective accumulation at the tumor site and facilitates superior T1 relaxation of water protons. Under 9 T MRI conditions, the RANP exhibits an r1 value of 1.88 mM−1 s−1 and a low r2/r1 ratio of 1.84, enabling the detection of primary esophageal tumors as small as 0.8 mm. This study significantly advances the sensitivity of current imaging techniques, pushing the detection limit of in vivo esophageal cancer diagnosis into the sub-millimeter range. Our results demonstrate the promising potential of RANP-enhanced UHF MRI for early detection, monitoring, and therapeutic intervention in esophageal cancer, offering a powerful tool for more effective clinical management.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defect-engineered iron single-site catalysts with tailored atomic coordination for enhanced mild photothermal therapy via triad modulation of apoptosis and ferroptosis 具有定制原子配位的缺陷工程铁单位点催化剂通过三合一调节细胞凋亡和铁凋亡来增强轻度光热治疗

IF 15.5

BMEMat Pub Date : 2026-03-27 Epub Date: 2025-11-28 DOI: 10.1002/bmm2.70051

Fanghua Zhang, Wendong Liu, Zhe Hao, Haijun Lu, Jinzheng Liu, Huajie Pang, Ruizhong Zhang, Xiyan Li, Zongjie Wang, Libing Zhang

{"title":"Defect-engineered iron single-site catalysts with tailored atomic coordination for enhanced mild photothermal therapy via triad modulation of apoptosis and ferroptosis","authors":"Fanghua Zhang, Wendong Liu, Zhe Hao, Haijun Lu, Jinzheng Liu, Huajie Pang, Ruizhong Zhang, Xiyan Li, Zongjie Wang, Libing Zhang","doi":"10.1002/bmm2.70051","DOIUrl":"10.1002/bmm2.70051","url":null,"abstract":"Mild photothermal therapy (MPTT) has emerged as a promising approach for cancer treatment. However, the rapid overexpression of heat shock proteins (HSPs) in cancer cells reduces its therapeutic efficacy. While strategies to suppress HSP expression or induce alternative cell death mechanisms, such as ferroptosis, show potential, overall outcomes remain suboptimal. In this study, we propose a triad material comprising defect-engineered single-site catalysts (DMOF), sodium nitroprusside, and HSP-targeting siRNA. Upon light exposure, this DMOF-SNP-siRNA (DSS) catalyst efficiently generates reactive species, suppresses HSP expression, and depletes intracellular glutathione, thereby inducing strong apoptotic and ferroptotic responses simultaneously. Compared to a defect-free metal-organic frameworks catalyst, the DSS single-site catalyst demonstrates significantly enhanced photothermal and catalytic properties, leading to remarkable tumor-killing capability while minimizing systemic toxicity. Notably, in a subcutaneously grafted tumor model, 60% of treated mice achieved complete remission after just two treatment sessions. Our findings establish a pioneering approach in the design of high-performance triad materials for advanced MPTT applications.","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"4 1","pages":""},"PeriodicalIF":15.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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