基于感染反应多糖的载药纳米组件,用于抗耐药细菌肺部感染的双模式治疗 (3/2024)

BMEMat Pub Date : 2024-09-24 DOI:10.1002/bmm2.12120
Lin Han, Zhonghua Yuan, Hui-Min Ren, Weizhuo Song, Ruonan Wu, Jie Li, Zhaoyan Guo, Bingran Yu, Shun Duan, Fu-Jian Xu
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引用次数: 0

摘要

本文编号为10.1002/bmm2.12120,通过带负电荷的多糖与带正电荷的季铵盐聚合物之间的静电作用,研制出一种感染反应性载药纳米组件STQ12。STQ12 可快速穿透粘液层,到达感染部位的酸性微环境,释放出负载的药物和 QPEI-C6,实现对多重耐药菌的联合抗感染治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024)

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024)

In this article number 10.1002/bmm2.12120, a kind of infection-responsive drug-loaded nano-assembly, STQ12, was developed by the electrostatic interaction between negatively charged polysaccharide and positively charged quaternized ammonium salt polymer. STQ12 could penetrate the mucus layer rapidly and reach the acidic microenvironment at the infected site, releasing the loaded drug and QPEI-C6 to realize combined anti-infection therapy against multi-drug resistant bacteria.

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