Advances in Sample Preparation最新文献_第6页

Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) 涂布叶片喷雾质谱法测定完整脑肿瘤中的酰基肉碱

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2024.100146

Joanna Bogusiewicz , Karol Jaroch , Jacek Furtak , Marcin Birski , Krystyna Soszyńska , Anna Majdańska , Agata Ryfa , Marek Harat , Barbara Bojko

{"title":"Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS)","authors":"Joanna Bogusiewicz , Karol Jaroch , Jacek Furtak , Marcin Birski , Krystyna Soszyńska , Anna Majdańska , Agata Ryfa , Marek Harat , Barbara Bojko","doi":"10.1016/j.sampre.2024.100146","DOIUrl":"10.1016/j.sampre.2024.100146","url":null,"abstract":"<div><div>Potential biomarkers of cancerous alterations could be selected by profiling a wide range of analytes. For this purpose, analytical platforms enabling detailed analysis of different biological matrices are applied. However, after biomarker selection, it is essential to shorten the analysis time as much as possible to speed up the diagnostic process. Therefore, this study aimed to optimize and test the coated blade spray mass spectrometry (CBS-MS) method in analyzing potential biomarkers in brain tumor studies: acylcarnitine. Meningiomas with different mutation statuses in NF2 were studied due to the relation of NF2 mutation with the higher risk of malignant transformation and multiple meningiomas. The application of CBS-MS enabled the determination of acetylcarnitine concentration (AC C2:0) and propionylcarnitine (AC C3:0) in intact tumor tissue. However, it would be necessary to enlarge the study group to confirm the conclusions on the concentration of these analytes in NF2 mutant and wild-type meningiomas. Apart from qualitative analysis, the simultaneous detection of a wide range of acylcarnitines in untargeted analysis was also possible.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100146"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES 最大限度地提高柑橘叶的神经保护作用：从压缩流体和NADES的顺序提取过程中优化混合提取物

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100149

Victor M. Amador-Luna, Miguel Herrero, Marta Jiménez de la Parra, Ángel Gómez Arribas, Elena Ibáñez, Lidia Montero

{"title":"Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES","authors":"Victor M. Amador-Luna, Miguel Herrero, Marta Jiménez de la Parra, Ángel Gómez Arribas, Elena Ibáñez, Lidia Montero","doi":"10.1016/j.sampre.2025.100149","DOIUrl":"10.1016/j.sampre.2025.100149","url":null,"abstract":"<div><div><em>Citrus aurantium</em>, also known as bitter orange, and the by-products obtained during its processing are a rich source of bioactive compounds. In particular, leaves from the tree pruning and from fruits harvesting are considered an agrifood-related waste with high valorization potential. Considering the wide variety of bioactive compounds present in the leaves (carotenoids, terpenes and phenolic compounds), this study is focused on the valorization of <em>C. aurantium</em> pruning waste through a sequential three-step extraction process using green extraction techniques, i.e. supercritical fluid extraction (SFE), followed by pressurized liquid extraction (PLE) using natural deep eutectic solvents (NADES), and an antisolvent extraction to recover the remaining bioactive compounds adsorbed to the NADES and extraction residues. In this sense, this is the first time that PLE using NADES followed by an antisolvent step to re-extract the compounds from the PLE residue is presented. Moreover, different protocols to efficiently remove the NADES from the PLE extract were also studied for the first time. Due to the different nature and bioactivity of the obtained extracts, the mixture of the three fractions was optimized to enhance its overall preventive potential against neurodegenerative diseases. Finally, its scalability to a semi-pilot scale was evaluated, giving rise to increased bioactive values of the blended extract.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100149"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Supramolecular Deep Eutectic Solvents based extraction for bioactive phenolic compounds recovery from olive pomace 基于可持续超分子深共晶溶剂的萃取技术，用于从橄榄渣中回收生物活性酚类化合物

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100166

G. Pietrangeli , S. Della Posta , E. D'Alessandro , S.M. Giannitelli , M. Trombetta , C. Maggi , L. De Gara , C. Fanali

{"title":"Sustainable Supramolecular Deep Eutectic Solvents based extraction for bioactive phenolic compounds recovery from olive pomace","authors":"G. Pietrangeli , S. Della Posta , E. D'Alessandro , S.M. Giannitelli , M. Trombetta , C. Maggi , L. De Gara , C. Fanali","doi":"10.1016/j.sampre.2025.100166","DOIUrl":"10.1016/j.sampre.2025.100166","url":null,"abstract":"<div><div>Olive oil industries produce a large quantity of by-product, such as wastewater and olive pomace, which are characterized by a high concentration of phenolic compounds, which can be recovered and eventually reused in cosmeceutical and nutraceutical fields. The recovery of bioactive molecules from waste is usually carried out by common of organic solvents. To respect the principles of green chemistry, other solvents such as Deep Eutectic Solvents (DESs) have been evaluated. DESs are sustainable solvents involved in sample preparation. Recently, DESs have also been evaluated as extraction solvent with the addition of β-cyclodextrins (β-CDs) which are cyclic oligosaccharide molecules obtained from the enzymatic degradation of starch, and their characteristics allow them to be selective toward certain analytes. These innovative solvents, called Supramolecular Deep Eutectic Solvents (SupraDESs), seem to be excellent green solvents for the extraction of phenolic compounds and are a sustainable alternative to conventional solvents. The aim of this work was to develop and optimize an analytical procedure for the extraction of phenolic compounds from olive pomace, using a SupraDES composed by ammonium acetate - lactic acid (in a molar ratio of 1:7) with the addition of a certain amount of β-cyclodextrins as extraction solvent. The optimized extraction procedure, defined through Box-Behnken Design, is based on the best extraction time of 22 min, temperature of 43°C, solid-to-liquid ratio of 1:48 (g:mL) and β-CDs concentration of 1.8 % (w/w). The qualitative profile of the extracted phenolic compounds was determined through high performance liquid chromatography coupled with mass spectrometry.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100166"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications 姜黄素：绿色提取方法和增溶途径的多方面综述，以最大限度地提高其食品和制药应用

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100159

Teshome Degfie Beshah , Mariam Araby Fekry saad , Sally el Gazar , Mohamed A. Farag

{"title":"Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications","authors":"Teshome Degfie Beshah , Mariam Araby Fekry saad , Sally el Gazar , Mohamed A. Farag","doi":"10.1016/j.sampre.2025.100159","DOIUrl":"10.1016/j.sampre.2025.100159","url":null,"abstract":"<div><div>Curcuminoids, chief polyphenols in Curcuma longa L. rhizome have extensive culinary and medicinal applications. In medicine, curcuminoids exhibit potential health benefits including anticancer, antimicrobial, antitumor, antidiabetic, neuroprotective, antioxidant, and cardioprotective properties. Additionally, curcuminoids are commonly used in culinary as a spice, flavoring agent, pigment, and food additive. Considering the potential value of curcuminoids and their difficulty to be synthesized, the development of effective extraction and purification techniques for their recovery from natural sources seems warranted. To meet the demands of food and nutraceutical industries, an effective curcuminoids’ extraction process should adhere to green chemistry principles in order to ensure efficiency, safety, environmental sustainability, minimal contaminants, and cost-effectiveness. This review focuses on several curcuminoids’ separation methods including traditional techniques, such as Soxhlet, maceration, and solvent extraction, as well as green advanced technologies including ultrasound-assisted extraction, enzyme-assisted extraction, extractions via pressurized liquid, supercritical fluid, pulsed electric field, three-phase partition, and deep eutectic solvents. A comparison is presented among the different extraction methods highlighting their advantages and limitations to aid future users in deciding on the best method that suit their needs. Lastly, approaches reported on improving curcuminoids’ solubility are also presented as part of this study to enhance their bioavailability and ultimate efficacy.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100159"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener solvents for microelution solid phase extraction of proteins from biological fluids followed by their top-down CE-MS analysis 更环保的微洗脱溶剂，固相萃取生物液中的蛋白质，然后进行自上而下的CE-MS分析

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100160

Martina Opetová , Radovan Tomašovský , Katarína Maráková

{"title":"Greener solvents for microelution solid phase extraction of proteins from biological fluids followed by their top-down CE-MS analysis","authors":"Martina Opetová , Radovan Tomašovský , Katarína Maráková","doi":"10.1016/j.sampre.2025.100160","DOIUrl":"10.1016/j.sampre.2025.100160","url":null,"abstract":"<div><div>In recent years, there has been a growing demand for making the analytical processes sustainable and environmentally friendly. In proteomic analysis, sample preparation plays an important role, employing different extraction techniques to isolate proteins of interest from biological fluids to be able to analyze them. These techniques usually use large volumes of organic solvents, such as acetonitrile, which has been recognized as hazardous and difficult to dispense. According to green analytical chemistry principles, the environmental impact of the methods can be reduced either by miniaturizing the processes or by replacing organic solvents with less toxic alternatives. This work compares the effect of different greener solvents on the solid-phase extraction process of low molecular weight proteins spiked in biological fluids (pooled human serum, plasma, urine, and saliva) and suggests that ethanol (60 %, v/v) offers, when used as an elution solvent, comparable results to acetonitrile (75 % v/v) in terms of extraction recovery. The addition of acidic modifiers to the elution solvent did not improve the extraction recovery, and the nitrogen evaporation of the eluate resulted in a 17–53 % loss of the proteins compared to the simple dilution of the eluate.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100160"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated capillary electrophoresis analyses of dried blood samples after patient-centric volumetric absorptive microsampling 以病人为中心的体积吸收显微取样后干血样的自动毛细管电泳分析

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2024.100142

Richard Maršala , Miloš Dvořák , Pavel Kubáň

{"title":"Automated capillary electrophoresis analyses of dried blood samples after patient-centric volumetric absorptive microsampling","authors":"Richard Maršala , Miloš Dvořák , Pavel Kubáň","doi":"10.1016/j.sampre.2024.100142","DOIUrl":"10.1016/j.sampre.2024.100142","url":null,"abstract":"<div><div>An automated method for the analysis of dried blood samples collected by volumetric absorptive microsampling (VAMS) is presented for the first time. A single commercial capillary electrophoresis (CE) instrument (with no need for hardware or software modifications) was employed for the expeditious analyses of the dried material using several integral and novel features. These included the use of external pressure for sub-minute sample preparation from Mitra® VAMS polymeric tips, the use of the sampling tips as inherent micro-agitators for instant eluate homogenization, preparation/sampling at the CE outlet for more convenient capillary length adjustment, and short-end injection for sub-minute CE separation and quantification of lactate as a model analyte.</div><div>The operational parameters for the sample preparation and analysis were comprehensively evaluated resulting in a baseline separation of lactate from all endogenous matrix compounds. The optimized method demonstrated excellent intra- and inter-day repeatability of peak areas (RSD values ≤ 7.2 %), linearity (R² = 0.9990) over the clinically relevant concentration range (0.15 – 20 mM), the limits of detection and quantification at 0.03 and 0.1 mM, respectively, and a sample throughput ≥ 16 samples/hour. No ageing was observed for VAMS devices stored at ambient conditions for up to 14 days. Comparative analysis with a portable lactate analyser revealed slightly elevated concentrations in dried vs. liquid capillary blood due to the glycolysis of glucose during drying, nevertheless, lactate concentrations in Mitra® devices correlated well with those in blood plasma, which is typically used in clinical practice.</div><div>The present study offers a robust, accurate, and environmentally benign concept for the automated analyses of VAMS-collected blood samples with its potential application in patient-centric sampling, clinical diagnostics and research, and personalized healthcare.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100142"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DES modified silica gel as dispersing material for miniaturized matrix solid phase dispersion applied to triazoles determination DES改性硅胶作为分散材料，用于三唑类化合物的微型基质固相分散测定

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100153

Susanna Della Posta , Valeria Gallo , Emanuele Limiti , Marcella Trombetta , Monica Gherardi , Alessandra Gentili , Laura De Gara , Chiara Fanali

{"title":"DES modified silica gel as dispersing material for miniaturized matrix solid phase dispersion applied to triazoles determination","authors":"Susanna Della Posta , Valeria Gallo , Emanuele Limiti , Marcella Trombetta , Monica Gherardi , Alessandra Gentili , Laura De Gara , Chiara Fanali","doi":"10.1016/j.sampre.2025.100153","DOIUrl":"10.1016/j.sampre.2025.100153","url":null,"abstract":"<div><div>Matrix solid phase dispersion (MSPD) represents one of the most useful methods for pesticides determination in vegetables. This extraction method involves the use of a solid, dispersing material, which is homogenized together with the sample in a mortar and loaded into a cartridge for the analyte's elution with a suitable solvent. Innovative MSPDs involve the use, as dispersing material, of silica gel (SCG) impregnated with deep eutectic solvents (DESs). SCG high porosity can facilitate DES impregnation process due to hydrogen bonds or electrostatic interactions among them.</div><div>A miniaturized MSPD extraction for triazoles from tomato using as dispersant DES modified SCG, followed by HPLC-MS extracts analysis, was developed. Four DES modified SCGs were tested in the MSPD procedure and the best result in terms of extracted triazoles was obtained using a choline chloride – Propylene Glycol DES modified SCG. Ethyl Acetate was selected as MSPD procedure extractive solvent resulting more efficient than methanol, acetonitrile and chloroform. The optimization of the extraction procedure involved the study of SCG to DES ratio (w/v), sample to dispersing material ratio (w/w) and extractive solvent volume able to obtain the greatest recovery of triazoles from tomato. The optimized method was validated and maximum values of 3.6 % and 8.3 % were obtained for intra-day and inter-day precision respectively. For each analyte the calculated limit of quantification was similar or lower than their Maximum Residue Limit. Triazoles mean recovery ranged from 70 to 102 %.</div><div>The new ChCl-propylene glycol DES modified SCG represents a valid alternative to conventional dispersing material in MSPD procedure apply to pesticides determination.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100153"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The solvent-assisted dispersive solid-phase extraction method revisited. Application for the determination of anionic surfactants 对溶剂辅助分散固相萃取法进行了研究。阴离子表面活性剂的测定方法

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100162

Serhii Zaruba , Patrycja Makoś-Chełstowska , Vasil Andruch

{"title":"The solvent-assisted dispersive solid-phase extraction method revisited. Application for the determination of anionic surfactants","authors":"Serhii Zaruba , Patrycja Makoś-Chełstowska , Vasil Andruch","doi":"10.1016/j.sampre.2025.100162","DOIUrl":"10.1016/j.sampre.2025.100162","url":null,"abstract":"<div><div>A new approach in solvent-assisted dispersive solid-phase extraction (SA-DSPE) procedure using a supercooled liquid was developed. It demonstrates the first use of a supercooled liquid in this technique, in particular, and in chemical analysis in general. Moreover, to the best of our knowledge, this is the first work devoted to the determination of the total concentration of anionic surfactants (as LAS, Linear alkylbenzene sulfonate) using a micro-SPE technique. The method is based on the formation of an ion pair between astraphloxine (cationic dye) and an anionic surfactants, with subsequent extraction of the ion pair formed onto a benzophenone sorbent generated <em>in situ</em> after injection of its 5 % solution in an acetone:water 80:20 v/v mixture into an aqueous sample. The resulting turbidness was sedimented by centrifugation. The addition of a few crystals of benzophenone then leads to the solidification of a supercooled solution of the sorbent, which facilitates the separation. Afterwards, the bulk of the aqueous phase was easily decanted, and the resulting sediment was dissolved with 500 μL of acetone; absorbance measurements were carried out in a semi-microcuvette. The calibration plot was linear up to 0.5 µmol L<sup>−1</sup> of sodium dodecylbenzene sulfonate (SDBS). The LOD and LOQ, were 9.0 and 30 nmol L<sup>-1</sup> of SDBS, respectively. The developed procedure was applied for the determination of anionic surfactants in various real water samples.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100162"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of deep eutectic solvents for the determination of inorganic analytes 深共晶溶剂测定无机分析物的应用

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100158

Vasil Andruch , Viera Vojteková , Alina Kalyniukova , Gokhan Zengin , Ingrid Hagarová , Tanya Yordanova

引用次数: 0

Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients 金属-有机骨架在药物活性成分选择性固相萃取和色谱分离中的应用进展

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100151

Zhenyu Song , Bodong Liu , Zezhou Zang , Zeyi Li , Ying Jiang , Tiantian Si , Min Sun

{"title":"Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients","authors":"Zhenyu Song , Bodong Liu , Zezhou Zang , Zeyi Li , Ying Jiang , Tiantian Si , Min Sun","doi":"10.1016/j.sampre.2025.100151","DOIUrl":"10.1016/j.sampre.2025.100151","url":null,"abstract":"<div><div>Active pharmaceutical ingredients (APIs) constitute a fundamental component in the development and clinical application of pharmaceuticals, thereby playing an indispensable and pivotal role within the realm of biomedicine. In current research, metal-organic frameworks (MOFs) have garnered considerable attention for studying APIs, serving as effective adsorbents for the extraction of APIs or as stationary phases for their separation. Notably, MOFs composites have significantly enhanced the enrichment and selectivity for APIs by modifying their size, micropore structure, surface characteristics, and charge. The mechanisms underlying these improvements include hydrogen bonding, π-stacking interactions, electrostatic interactions, hydrophobic interactions, and hydrophilic interactions. This comprehensive review focuses on the latest advancements and breakthroughs in the application of MOFs for selective extraction, enrichment, and chromatographic separation of APIs within solid-phase extraction, solid-phase microextraction, and chromatographic stationary phases spanning the period from 2020 to 2024. Additionally, the review highlights the potential development of MOFs in sample preparation chromatographic separation for application, particularly for APIs derived from traditional Chinese medicine (TCM), providing valuable insights into the research and development of nanomaterials such as MOFs in using APIs.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100151"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0