姜黄素:绿色提取方法和增溶途径的多方面综述,以最大限度地提高其食品和制药应用

IF 6.5 Q1 CHEMISTRY, ANALYTICAL
Teshome Degfie Beshah , Mariam Araby Fekry saad , Sally el Gazar , Mohamed A. Farag
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引用次数: 0

摘要

姜黄素是姜黄根茎中主要的多酚类物质,具有广泛的烹饪和药用价值。在医学上,姜黄素显示出潜在的健康益处,包括抗癌、抗菌、抗肿瘤、抗糖尿病、神经保护、抗氧化和心脏保护特性。此外,姜黄素在烹饪中通常用作香料、调味剂、色素和食品添加剂。考虑到姜黄素的潜在价值及其合成的难度,开发有效的提取和纯化技术从天然来源中回收姜黄素似乎是必要的。为了满足食品和营养保健行业的需求,有效的姜黄素提取工艺应遵循绿色化学原则,以确保效率、安全性、环境可持续性、最小污染物和成本效益。综述了姜黄素的几种分离方法,包括索氏法、浸渍法、溶剂萃取法等传统方法,以及超声辅助萃取法、酶辅助萃取法、加压液萃取法、超临界流体萃取法、脉冲电场萃取法、三相萃取法、深共晶溶剂萃取法等绿色先进技术。对不同的提取方法进行了比较,突出了它们的优点和局限性,以帮助未来的用户决定适合他们需要的最佳方法。最后,本研究还介绍了改善姜黄素溶解度的方法,以提高其生物利用度和最终疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications

Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications
Curcuminoids, chief polyphenols in Curcuma longa L. rhizome have extensive culinary and medicinal applications. In medicine, curcuminoids exhibit potential health benefits including anticancer, antimicrobial, antitumor, antidiabetic, neuroprotective, antioxidant, and cardioprotective properties. Additionally, curcuminoids are commonly used in culinary as a spice, flavoring agent, pigment, and food additive. Considering the potential value of curcuminoids and their difficulty to be synthesized, the development of effective extraction and purification techniques for their recovery from natural sources seems warranted. To meet the demands of food and nutraceutical industries, an effective curcuminoids’ extraction process should adhere to green chemistry principles in order to ensure efficiency, safety, environmental sustainability, minimal contaminants, and cost-effectiveness. This review focuses on several curcuminoids’ separation methods including traditional techniques, such as Soxhlet, maceration, and solvent extraction, as well as green advanced technologies including ultrasound-assisted extraction, enzyme-assisted extraction, extractions via pressurized liquid, supercritical fluid, pulsed electric field, three-phase partition, and deep eutectic solvents. A comparison is presented among the different extraction methods highlighting their advantages and limitations to aid future users in deciding on the best method that suit their needs. Lastly, approaches reported on improving curcuminoids’ solubility are also presented as part of this study to enhance their bioavailability and ultimate efficacy.
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