金属-有机骨架在药物活性成分选择性固相萃取和色谱分离中的应用进展

IF 6.5 Q1 CHEMISTRY, ANALYTICAL
Zhenyu Song , Bodong Liu , Zezhou Zang , Zeyi Li , Ying Jiang , Tiantian Si , Min Sun
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引用次数: 0

摘要

活性药物成分是药物开发和临床应用的基础成分,在生物医学领域中起着不可或缺的关键作用。在目前的研究中,金属有机骨架(MOFs)作为有效的吸附剂用于原料药的提取或作为固定相用于原料药的分离,在原料药的研究中受到了广泛的关注。值得注意的是,mof复合材料通过改变其尺寸、微孔结构、表面特征和电荷,显著提高了原料药的富集和选择性。这些改进的机制包括氢键、π堆积相互作用、静电相互作用、疏水相互作用和亲水相互作用。本文综述了2020年至2024年mof在固相萃取、固相微萃取和色谱固定相中选择性提取、富集和色谱分离原料药的最新进展和突破。此外,本文还强调了mof在样品制备色谱分离中的应用潜力,特别是在中药原料药的应用方面,为mof等纳米材料在原料药应用方面的研究和开发提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients

Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients
Active pharmaceutical ingredients (APIs) constitute a fundamental component in the development and clinical application of pharmaceuticals, thereby playing an indispensable and pivotal role within the realm of biomedicine. In current research, metal-organic frameworks (MOFs) have garnered considerable attention for studying APIs, serving as effective adsorbents for the extraction of APIs or as stationary phases for their separation. Notably, MOFs composites have significantly enhanced the enrichment and selectivity for APIs by modifying their size, micropore structure, surface characteristics, and charge. The mechanisms underlying these improvements include hydrogen bonding, π-stacking interactions, electrostatic interactions, hydrophobic interactions, and hydrophilic interactions. This comprehensive review focuses on the latest advancements and breakthroughs in the application of MOFs for selective extraction, enrichment, and chromatographic separation of APIs within solid-phase extraction, solid-phase microextraction, and chromatographic stationary phases spanning the period from 2020 to 2024. Additionally, the review highlights the potential development of MOFs in sample preparation chromatographic separation for application, particularly for APIs derived from traditional Chinese medicine (TCM), providing valuable insights into the research and development of nanomaterials such as MOFs in using APIs.
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