Advances in Sample Preparation最新文献_第3页

DES modified silica gel as dispersing material for miniaturized matrix solid phase dispersion applied to triazoles determination

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100153

Susanna Della Posta , Valeria Gallo , Emanuele Limiti , Marcella Trombetta , Monica Gherardi , Alessandra Gentili , Laura De Gara , Chiara Fanali

{"title":"DES modified silica gel as dispersing material for miniaturized matrix solid phase dispersion applied to triazoles determination","authors":"Susanna Della Posta , Valeria Gallo , Emanuele Limiti , Marcella Trombetta , Monica Gherardi , Alessandra Gentili , Laura De Gara , Chiara Fanali","doi":"10.1016/j.sampre.2025.100153","DOIUrl":"10.1016/j.sampre.2025.100153","url":null,"abstract":"<div><div>Matrix solid phase dispersion (MSPD) represents one of the most useful methods for pesticides determination in vegetables. This extraction method involves the use of a solid, dispersing material, which is homogenized together with the sample in a mortar and loaded into a cartridge for the analyte's elution with a suitable solvent. Innovative MSPDs involve the use, as dispersing material, of silica gel (SCG) impregnated with deep eutectic solvents (DESs). SCG high porosity can facilitate DES impregnation process due to hydrogen bonds or electrostatic interactions among them.</div><div>A miniaturized MSPD extraction for triazoles from tomato using as dispersant DES modified SCG, followed by HPLC-MS extracts analysis, was developed. Four DES modified SCGs were tested in the MSPD procedure and the best result in terms of extracted triazoles was obtained using a choline chloride – Propylene Glycol DES modified SCG. Ethyl Acetate was selected as MSPD procedure extractive solvent resulting more efficient than methanol, acetonitrile and chloroform. The optimization of the extraction procedure involved the study of SCG to DES ratio (w/v), sample to dispersing material ratio (w/w) and extractive solvent volume able to obtain the greatest recovery of triazoles from tomato. The optimized method was validated and maximum values of 3.6 % and 8.3 % were obtained for intra-day and inter-day precision respectively. For each analyte the calculated limit of quantification was similar or lower than their Maximum Residue Limit. Triazoles mean recovery ranged from 70 to 102 %.</div><div>The new ChCl-propylene glycol DES modified SCG represents a valid alternative to conventional dispersing material in MSPD procedure apply to pesticides determination.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100153"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated capillary electrophoresis analyses of dried blood samples after patient-centric volumetric absorptive microsampling

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2024.100142

Richard Maršala , Miloš Dvořák , Pavel Kubáň

{"title":"Automated capillary electrophoresis analyses of dried blood samples after patient-centric volumetric absorptive microsampling","authors":"Richard Maršala , Miloš Dvořák , Pavel Kubáň","doi":"10.1016/j.sampre.2024.100142","DOIUrl":"10.1016/j.sampre.2024.100142","url":null,"abstract":"<div><div>An automated method for the analysis of dried blood samples collected by volumetric absorptive microsampling (VAMS) is presented for the first time. A single commercial capillary electrophoresis (CE) instrument (with no need for hardware or software modifications) was employed for the expeditious analyses of the dried material using several integral and novel features. These included the use of external pressure for sub-minute sample preparation from Mitra® VAMS polymeric tips, the use of the sampling tips as inherent micro-agitators for instant eluate homogenization, preparation/sampling at the CE outlet for more convenient capillary length adjustment, and short-end injection for sub-minute CE separation and quantification of lactate as a model analyte.</div><div>The operational parameters for the sample preparation and analysis were comprehensively evaluated resulting in a baseline separation of lactate from all endogenous matrix compounds. The optimized method demonstrated excellent intra- and inter-day repeatability of peak areas (RSD values ≤ 7.2 %), linearity (R² = 0.9990) over the clinically relevant concentration range (0.15 – 20 mM), the limits of detection and quantification at 0.03 and 0.1 mM, respectively, and a sample throughput ≥ 16 samples/hour. No ageing was observed for VAMS devices stored at ambient conditions for up to 14 days. Comparative analysis with a portable lactate analyser revealed slightly elevated concentrations in dried vs. liquid capillary blood due to the glycolysis of glucose during drying, nevertheless, lactate concentrations in Mitra® devices correlated well with those in blood plasma, which is typically used in clinical practice.</div><div>The present study offers a robust, accurate, and environmentally benign concept for the automated analyses of VAMS-collected blood samples with its potential application in patient-centric sampling, clinical diagnostics and research, and personalized healthcare.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100142"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener solvents for microelution solid phase extraction of proteins from biological fluids followed by their top-down CE-MS analysis

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100160

Martina Opetová , Radovan Tomašovský , Katarína Maráková

{"title":"Greener solvents for microelution solid phase extraction of proteins from biological fluids followed by their top-down CE-MS analysis","authors":"Martina Opetová , Radovan Tomašovský , Katarína Maráková","doi":"10.1016/j.sampre.2025.100160","DOIUrl":"10.1016/j.sampre.2025.100160","url":null,"abstract":"<div><div>In recent years, there has been a growing demand for making the analytical processes sustainable and environmentally friendly. In proteomic analysis, sample preparation plays an important role, employing different extraction techniques to isolate proteins of interest from biological fluids to be able to analyze them. These techniques usually use large volumes of organic solvents, such as acetonitrile, which has been recognized as hazardous and difficult to dispense. According to green analytical chemistry principles, the environmental impact of the methods can be reduced either by miniaturizing the processes or by replacing organic solvents with less toxic alternatives. This work compares the effect of different greener solvents on the solid-phase extraction process of low molecular weight proteins spiked in biological fluids (pooled human serum, plasma, urine, and saliva) and suggests that ethanol (60 %, v/v) offers, when used as an elution solvent, comparable results to acetonitrile (75 % v/v) in terms of extraction recovery. The addition of acidic modifiers to the elution solvent did not improve the extraction recovery, and the nitrogen evaporation of the eluate resulted in a 17–53 % loss of the proteins compared to the simple dilution of the eluate.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100160"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The solvent-assisted dispersive solid-phase extraction method revisited. Application for the determination of anionic surfactants

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100162

Serhii Zaruba , Patrycja Makoś-Chełstowska , Vasil Andruch

{"title":"The solvent-assisted dispersive solid-phase extraction method revisited. Application for the determination of anionic surfactants","authors":"Serhii Zaruba , Patrycja Makoś-Chełstowska , Vasil Andruch","doi":"10.1016/j.sampre.2025.100162","DOIUrl":"10.1016/j.sampre.2025.100162","url":null,"abstract":"<div><div>A new approach in solvent-assisted dispersive solid-phase extraction (SA-DSPE) procedure using a supercooled liquid was developed. It demonstrates the first use of a supercooled liquid in this technique, in particular, and in chemical analysis in general. Moreover, to the best of our knowledge, this is the first work devoted to the determination of the total concentration of anionic surfactants (as LAS, Linear alkylbenzene sulfonate) using a micro-SPE technique. The method is based on the formation of an ion pair between astraphloxine (cationic dye) and an anionic surfactants, with subsequent extraction of the ion pair formed onto a benzophenone sorbent generated <em>in situ</em> after injection of its 5 % solution in an acetone:water 80:20 v/v mixture into an aqueous sample. The resulting turbidness was sedimented by centrifugation. The addition of a few crystals of benzophenone then leads to the solidification of a supercooled solution of the sorbent, which facilitates the separation. Afterwards, the bulk of the aqueous phase was easily decanted, and the resulting sediment was dissolved with 500 μL of acetone; absorbance measurements were carried out in a semi-microcuvette. The calibration plot was linear up to 0.5 µmol L<sup>−1</sup> of sodium dodecylbenzene sulfonate (SDBS). The LOD and LOQ, were 9.0 and 30 nmol L<sup>-1</sup> of SDBS, respectively. The developed procedure was applied for the determination of anionic surfactants in various real water samples.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100162"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100151

Zhenyu Song , Bodong Liu , Zezhou Zang , Zeyi Li , Ying Jiang , Tiantian Si , Min Sun

{"title":"Advances in applications of metal-organic frameworks for selective solid-phase extraction and chromatographic separation of active pharmaceutical ingredients","authors":"Zhenyu Song , Bodong Liu , Zezhou Zang , Zeyi Li , Ying Jiang , Tiantian Si , Min Sun","doi":"10.1016/j.sampre.2025.100151","DOIUrl":"10.1016/j.sampre.2025.100151","url":null,"abstract":"<div><div>Active pharmaceutical ingredients (APIs) constitute a fundamental component in the development and clinical application of pharmaceuticals, thereby playing an indispensable and pivotal role within the realm of biomedicine. In current research, metal-organic frameworks (MOFs) have garnered considerable attention for studying APIs, serving as effective adsorbents for the extraction of APIs or as stationary phases for their separation. Notably, MOFs composites have significantly enhanced the enrichment and selectivity for APIs by modifying their size, micropore structure, surface characteristics, and charge. The mechanisms underlying these improvements include hydrogen bonding, π-stacking interactions, electrostatic interactions, hydrophobic interactions, and hydrophilic interactions. This comprehensive review focuses on the latest advancements and breakthroughs in the application of MOFs for selective extraction, enrichment, and chromatographic separation of APIs within solid-phase extraction, solid-phase microextraction, and chromatographic stationary phases spanning the period from 2020 to 2024. Additionally, the review highlights the potential development of MOFs in sample preparation chromatographic separation for application, particularly for APIs derived from traditional Chinese medicine (TCM), providing valuable insights into the research and development of nanomaterials such as MOFs in using APIs.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100151"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener and rapid magnetic solid phase microextraction method using Fe3O4@Al2O3/AC for chromatographic determination of neonicotinoid pesticides in vegetable oils

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100152

Musiiwa V. Sengane , Masixole Sihlahla , Philiswa N. Nomngongo , Nomvano Mketo

{"title":"Greener and rapid magnetic solid phase microextraction method using Fe3O4@Al2O3/AC for chromatographic determination of neonicotinoid pesticides in vegetable oils","authors":"Musiiwa V. Sengane , Masixole Sihlahla , Philiswa N. Nomngongo , Nomvano Mketo","doi":"10.1016/j.sampre.2025.100152","DOIUrl":"10.1016/j.sampre.2025.100152","url":null,"abstract":"<div><div>A greener sample preparation method based on magnetic solid phase microextraction (MSPμE) was developed for the preconcentration of neonicotinoid pesticides (acetamiprid, imidacloprid, thiacloprid and thiamethoxam) in vegetable oil samples followed by separation and quantification using high performance liquid chromatography with diode array detector (HPLC-DAD). Different characterisation techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Powder X-ray diffraction analysis (PXRD), Thermogravimetric Analysis (TGA), Transmission electron microscopy (TEM), and scanning electron microscope and energy-dispersive X-ray spectroscopy (SEM-EDS) confirmed the synthesised magnetic nano adsorbents (Fe<sub>3</sub>O<sub>4</sub>, Fe<sub>3</sub>O<sub>4</sub>@Al<sub>2</sub>O<sub>3</sub> and Fe<sub>3</sub>O<sub>4</sub>@Al<sub>2</sub>O<sub>3</sub>/AC). The most influential parameters affecting MSPμE of NEOs by Fe<sub>3</sub>O<sub>4</sub>@Al<sub>2</sub>O<sub>3</sub>/AC were examined using a multivariate optimisation approach and 8 min extraction time, 13 pH, 9 mg adsorbent mass, and 0.5 mL eluent volume were optimal parameters. The proposed Fe3O4@Al2O3/AC method showed high accuracy (80–119.21%) and precision (≤10 %) for all the investigated NEOs. Additionally, the obtained limit of detection (LOD) ranged from 0.5–1.76 ng µL<sup>-1</sup>, the limit of quantification (LOQ) ranged from 1.87–6.62 ng µL<sup>-1</sup> and satisfactory high preconcentration factors (73.02- 407.0) were comparable with literature reported studies. The Analytical GREEness calculator AGREE, BAGI and NEMI analysis confirmed greenness of MSPμE. After that, the validated MSPμE method was applied to real vegetable oil samples (avocado, canola, olive and sunflower), and fortunately, all the investigated NEOs were below LODs of the proposed MSPμE /HPLC-DAD methods.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100152"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of deep eutectic solvents for the determination of inorganic analytes

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100158

Vasil Andruch , Viera Vojteková , Alina Kalyniukova , Gokhan Zengin , Ingrid Hagarová , Tanya Yordanova

引用次数: 0

Vial-coated thin film microextraction for perfluoroalkyl carboxylic acids (PFCAs) determination in water by GC–MS

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100147

J․Mabel Luna-Díaz , Luz O․ Leal-Quezada , Laura Ferrer , Edwin Palacio

{"title":"Vial-coated thin film microextraction for perfluoroalkyl carboxylic acids (PFCAs) determination in water by GC–MS","authors":"J․Mabel Luna-Díaz , Luz O․ Leal-Quezada , Laura Ferrer , Edwin Palacio","doi":"10.1016/j.sampre.2025.100147","DOIUrl":"10.1016/j.sampre.2025.100147","url":null,"abstract":"<div><div>Perfluoroalkyl carboxylic acids (PFCAs), a subclass of perfluoroalkyl substances (PFAs) commonly detected in water, are of increasing concern due to their persistence, bioaccumulative nature, and harmful effects on health. Determining PFCAs in environmental matrices is challenging because they are typically present at ng L⁻¹ levels and tend to adsorb onto materials like filtration membranes, causing significant losses during analysis. To address these challenges, a thin-film microextraction (TFME)-coated vial was designed for PFCA (C5–C10) extraction, coupled with gas chromatography-mass spectrometry (GC–MS). Glass was selected as the support material due to its low adsorption rate and superior chemical resistance compared to other polymers. The TFME coating, made from a weak anion exchange resin and polyacrylonitrile (10 % w/w) as a binder polymer, effectively extracts analytes from complex matrices while minimizing co-extraction of interfering macromolecules. The method eliminates the need for sample filtration, preventing PFCA loss in filtration membranes. Under optimal conditions, the extraction efficiency ranged from 70 to 100 %. Detection and quantification limits were 0.13–2.1 ng L⁻¹ and 0.42–7.1 ng L⁻¹, respectively. Intra- and inter-assay relative standard deviations (% RSD) were 4.9–2.2 % and 4.8–2.3 %, respectively, with a linear working range of 10–1000 ng L⁻¹ for the TFME-coated device. This method is suitable for PFCA determination in drinking water and complies with the Directive 2020/2184, which sets a maximum allowable limit of 500 ng L⁻¹ for total PFAs.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100147"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an automated sorptive extraction system for trace analysis in water

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100156

Frank Jacobs , Dr. Klaus Kerpen , Dr. Eike Kleine-Benne , PD Dr. Ursula Telgheder

{"title":"Development of an automated sorptive extraction system for trace analysis in water","authors":"Frank Jacobs , Dr. Klaus Kerpen , Dr. Eike Kleine-Benne , PD Dr. Ursula Telgheder","doi":"10.1016/j.sampre.2025.100156","DOIUrl":"10.1016/j.sampre.2025.100156","url":null,"abstract":"<div><div>Stir bar sorptive extraction (SBSE) is an established microextraction technique developed in the early 2000s. It has gained widespread use in laboratories around the world, but always had one drawback in that it was a manual sample preparation technique. The newly developed system presented in this study aims to combine the well-known characteristics of SBSE with fully automated sample preparation. The presented system is based on a novel sample probe design, which uses the same dimensions and materials of sorbent phase as the commercially available Gerstel Twister® SBSE technology. To test the performance of this system, pesticides were extracted from pure water as well as river water. Limits of detection (4.5 ng/L to 53.6 ng/L) and quantification (15.7 ng/L to 327.6 ng/L) as well as standard method deviation (3.2 % to 37.6 %) were determined for 21 pesticides based on DIN EN ISO 27,108, part of the water framework directive (WFR). Standard addition was used to quantify pesticides in river water matrix. To check the performance of the new development, it was compared to established methods like manual SBSE, thin film micro extraction (TFME) and SPME-Arrow. The results are comparable between automated sorptive extraction (ASE) and SBSE (average of 84 % compared to automated system), as expected. Performance compared to TFME (65 %) and SPME-Arrow (3 %) was significantly better, especially to the latter. These results show that the automated sorptive extraction system developed in this paper is competitive with already established techniques.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100156"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New trends in bioanalysis sampling and pretreatment: How modern microsampling is revolutionising the field

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100161

Michele Protti , Elisa Milandri , Roberta Di Lecce , Laura Mercolini , Roberto Mandrioli

{"title":"New trends in bioanalysis sampling and pretreatment: How modern microsampling is revolutionising the field","authors":"Michele Protti , Elisa Milandri , Roberta Di Lecce , Laura Mercolini , Roberto Mandrioli","doi":"10.1016/j.sampre.2025.100161","DOIUrl":"10.1016/j.sampre.2025.100161","url":null,"abstract":"<div><div>Microsampling technologies are revolutionising bioanalysis by enabling minimally invasive, decentralized sample collection, offering significant advantages over traditional methods in terms of patient compliance, cost-effectiveness, and analytical efficiency. This review explores the latest advancements in microsampling devices, including microfluidic and quantitative dried blood spot systems (mfDBS and qDBS, respectively), calibrated capillary-based devices, volumetric absorptive microsampling (VAMS) technologies, microneedle-based microsampling, radial-based DBS devices, membrane-based plasma separation technologies and vacuum-assisted blood collection systems. By addressing pre-analytical variability, enhancing analyte stability, and supporting decentralized workflows, these technologies align with modern and green analytical chemistry principles. The unique capabilities of these emerging microsampling technologies and devices further demonstrate their transformative potential. However, challenges remain, including haematocrit dependency for some parameters, user variability, and standardisation across devices. This review highlights ongoing innovations and their implications for expanding to high-quality bioanalytical testing.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100161"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0