Advances in Sample Preparation最新文献_第2页

Monitoring of 12 DBPs in drinking water using a microextraction TD-GC-MS method

IF 5.2

Advances in Sample Preparation Pub Date : 2025-03-03 DOI: 10.1016/j.sampre.2025.100168

Photini Papaioakeim , Efstathios A. Elia , Agapios Agapiou

{"title":"Monitoring of 12 DBPs in drinking water using a microextraction TD-GC-MS method","authors":"Photini Papaioakeim , Efstathios A. Elia , Agapios Agapiou","doi":"10.1016/j.sampre.2025.100168","DOIUrl":"10.1016/j.sampre.2025.100168","url":null,"abstract":"<div><div>Disinfection of drinking water is essential for ensuring public health; however, it leads to the formation of various undesirable disinfection by-products (DBPs). To comply with the recent European Union (EU) drinking water directive legislation (EU 2020/2184), a headspace HiSorb thermal desorption-gas chromatography-mass spectrometry (HS-HiSorb-TD-GC-MS) method was developed and validated for the quantification of 12 DBPs in drinking water. The HS-HiSorb-TD-GC-MS method presented high sensitivity and selectivity, linearity (1–120 ppb), limit of detection (LOD) 0.33–3.33 ppb, and limit of quantification (LOQ) 1–10 ppb. The method's accuracy was verified at three different concentrations, showing good repeatability (intra-day) and reproducibility (inter-day), ranging from 1.3 to 10 % and 3.3–15 %, respectively. Additionally, the method's recovery rates, at 10 ppb and 50 ppb, were estimated between 80 and 120 %. Water sample stability was also examined at various temperatures (4°C, 25°C, -20°C). The HS-HiSorb-TD-GC-MS method was used to investigate the presence of DBPs in tap water samples, highlighting its applicability to drinking water monitoring. The development of a green analytical method based on a sorbent-based sample preparation technique, contributes to sustainable and green analytical chemistry.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"14 ","pages":"Article 100168"},"PeriodicalIF":5.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the greenness of molecularly imprinted polymers used in sample preparation 评估用于样品制备的分子印迹聚合物的绿色环保性

IF 5.2

Advances in Sample Preparation Pub Date : 2025-03-02 DOI: 10.1016/j.sampre.2025.100167

Mariusz Marć , A. Martín-Esteban

{"title":"Assessment of the greenness of molecularly imprinted polymers used in sample preparation","authors":"Mariusz Marć , A. Martín-Esteban","doi":"10.1016/j.sampre.2025.100167","DOIUrl":"10.1016/j.sampre.2025.100167","url":null,"abstract":"<div><div>It is now widely accepted that the incorporation of molecularly imprinted polymers (MIPs) into sample preparation techniques has enabled unprecedented selectivity performance of analytical methods for the determination of a wide range of analytes in biological, food and environmental samples. However, according to the Principles of Green Chemistry and the subsequent Principles of Green Sample Preparation, it is clear that MIPs are far from being considered green materials, both due to the common harmful reagents and the experimental conditions used for their synthesis. Accordingly, new greener routes for MIP synthesis have been proposed in recent years. However, although the titles of some of the published papers include terms such as 'green MIP' or 'sustainable MIP', such improved properties have only been assessed intuitively and it is therefore unclear whether such claimed green or sustainable MIPs are actually so. Therefore, in the present review, published papers using apparently green MIPs in sample preparation were evaluated using the recently developed metric tool AGREEMIP. Such a tool is based on the assessment of 12 criteria related to the greenness of the different reagents used, energy requirements and other aspects of MIP synthesis procedures. The final values of performed AGREEMIP assessment ranged from 0.28 to 0.80. The scores obtained after the AGREEMIP assessment clearly show that, although slight improvements have been achieved in terms of greenness, there is an abuse of the use of green-related terms and further development is needed. In this context, some guidelines for greening MIPs are provided.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"14 ","pages":"Article 100167"},"PeriodicalIF":5.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener Solvents in Extraction of Proteins and Peptides

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-25 DOI: 10.1016/j.sampre.2025.100165

Katarína Maráková

{"title":"Greener Solvents in Extraction of Proteins and Peptides","authors":"Katarína Maráková","doi":"10.1016/j.sampre.2025.100165","DOIUrl":"10.1016/j.sampre.2025.100165","url":null,"abstract":"<div><div>The sample pretreatment still represents a fundamental aspect of any analytical workflow, and the implementation of sustainable and efficient extraction of proteins is essential to satisfy the increasing requirements for high-quality extraction of proteins from their natural sources. Proteins, with their unique structural and functional characteristics, are utilized in several industries such as pharmaceuticals, biomedicine, cosmetics, and food. Traditional methods for protein extraction depend predominantly on hazardous organic solvents, thereby presenting both environmental and health-related risks. Recent progress has been directed towards developing environmentally benign alternative extraction approaches. Ionic liquids and deep eutectic solvents have demonstrated in the recent decade great potential as green solvents for protein extraction, thanks to their tunable properties that can be customized to various extraction protocols; thus, they are characterized by high selectivity. At the same time, they usually cause minimal denaturation of proteins, which is essential for normal functioning of proteins. However, the industrial implementation of these solvents still encounters obstacles, such as the knowledge gaps about their solvating characteristics, complexity in their synthesis (especially for ionic liquids), and potential for their reusability. The present review paper deals with the recent advances in the extraction of proteins and peptides with ionic liquids and deep eutectic solvents, discusses the influence of solvent characteristics on the extraction process, describes various extraction methods, and presents prospective future directions in this field.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100165"},"PeriodicalIF":5.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Click Analytical Chemistry Index as a novel concept and framework, supported with open source software to assess analytical methods

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-23 DOI: 10.1016/j.sampre.2025.100164

Fotouh R. Mansour , Alaa Bedair , Marcello Locatelli

{"title":"Click Analytical Chemistry Index as a novel concept and framework, supported with open source software to assess analytical methods","authors":"Fotouh R. Mansour , Alaa Bedair , Marcello Locatelli","doi":"10.1016/j.sampre.2025.100164","DOIUrl":"10.1016/j.sampre.2025.100164","url":null,"abstract":"<div><div>Click analytical chemistry (CAC) is a novel approach inspired by the principles of click chemistry, emphasizing simplicity, efficiency, and reliability. While click chemistry revolutionized synthetic methods, CAC aims to enhance chemical analysis by providing a framework for method assessment from a different perspective, focusing on improving the practicality and applicability of analytical techniques. In this work, we present the Click Analytical Chemistry Index (CACI) as a practical and user-friendly tool that provides both a metric and software solution for evaluating analytical methods. The software is available as an open source at <span><span>bit.ly/CACI2025</span><svg><path></path></svg></span>. The CACI system allows for objective and unbiased comparisons between techniques, encouraging the development of methods that are easier to implement without sacrificing performance. By promoting simplicity and practicality in method design, CACI supports the development of analytical procedures that not only meet rigorous performance standards but also simplify the analytical process. This work explores the principles and methodology of CAC and presents case studies that demonstrate its practical applications in advancing chemical analysis towards more efficient method development and evaluation.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"14 ","pages":"Article 100164"},"PeriodicalIF":5.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-graphene oxide aerogel for in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2024.100144

Ziyi Jiang, Yanan Bu, Juanjuan Feng, Min Sun

{"title":"Polydopamine-graphene oxide aerogel for in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons","authors":"Ziyi Jiang, Yanan Bu, Juanjuan Feng, Min Sun","doi":"10.1016/j.sampre.2024.100144","DOIUrl":"10.1016/j.sampre.2024.100144","url":null,"abstract":"<div><div>Due to the wide distribution and potential carcinogenicity, teratogenicity and mutagenicity, polycyclic aromatic hydrocarbons (PAHs) have attracted much attention, requiring efficient and sensitive methods for detection. In order to improve the stability and extraction performance of graphene oxide aerogel, polydopamine was introduced to functionalize it. Polydopamine-hybridized graphene oxide aerogel was in-situ fabricated on the surface of titanium wire. The composite material was characterized by SEM and FT-IR. Three aerogel-coated wires were filled in a polyetheretherketone tube for in-tube solid-phase microextraction. Coupled with high performance liquid chromatography, the tube showed good extraction performance for several PAHs. Under the optimal conditions (sampling volume of 60 mL, sampling rate of 1.50 mL/min, sample pH of 7.3, 0.5 % (v/v) of methanol and 1.0 % (w/v) of NaCl in sample, desorption time of 1.0 min), an online analytical method was developed for determining trace PAHs from water samples, with low detection limits (0.01–0.05 μg/L), wide linear ranges (0.03–50 μg/L, 0.15–100 μg/L) with correlation coefficients (0.9953–0.9992) and satisfactory repeatability (RSDs, 0.22 %-4.42 % for intra-day, 1.42 %-5.18 % for inter-day). The method was applied to analyze some water samples including leaching solutions of coal ash and paper food box, some targets were found. The recoveries in these samples with different spiked levels (2.0 and 10.0 μg/L) were in the range of 81–117 %.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100144"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrogen-rich covalent organic polymers for efficient solid phase extraction of nonsteroidal anti-inflammatory drugs from water samples

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100148

Yuqi Cheng , Jia Li , Xiaochen Xiu , Xinghua Teng , Wen Zhang , Lei Ji , Leilei Wang

{"title":"Nitrogen-rich covalent organic polymers for efficient solid phase extraction of nonsteroidal anti-inflammatory drugs from water samples","authors":"Yuqi Cheng , Jia Li , Xiaochen Xiu , Xinghua Teng , Wen Zhang , Lei Ji , Leilei Wang","doi":"10.1016/j.sampre.2025.100148","DOIUrl":"10.1016/j.sampre.2025.100148","url":null,"abstract":"<div><div>Non-steroidal anti-inflammatory drugs (NSAIDs) have received increasing attention owing to their ubiquitous occurrence in environmental water systems and adverse effects. In order to monitor trace levels of NSAIDs from complex water samples, development of facile and efficient sample pretreatment is of great significance. Herein, a nitrogen-rich covalent organic polymer containing phenyl, triazine and amine groups was fabricated via solvent-free copolymerization. Then, utilizing nitrogen-rich covalent organic polymer as adsorbent for solid phase extraction cartridges, the pretreatment method was combined with high-performance liquid chromatography-diode array detection to quantify five representative NSAIDs (ketoprofen, carprofen, flurbiprofen, diclofenac and mefenamic acid) in environmental water samples. Under the optimal extraction conditions (adsorbent amount: 40 mg; NaCl concentration: 0%; pH 6; extraction time: 20min; eluent solvent: 4 mL of formic acid/acetonitrile (5%, v/v)), the proposed method provided low detection limits (0.06–0.2 μg L<sup>-1</sup>), wide linear ranges (0.2–100 μg L<sup>-1</sup>) with correlation coefficients (0.9991–0.9997) and acceptable precision (RSDs, 6.6–8.5% for intra-day, 7.2–9.5% for inter-day). The practical application of the method was confirmed through the successful determination of NSAIDs in tap water, surface water, and sewage. The recoveries in these samples at the four NSAIDs concentration levels ranged from 81.3% to 109.8%, with the RSDs lower than 7.8%.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100148"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS)

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2024.100146

Joanna Bogusiewicz , Karol Jaroch , Jacek Furtak , Marcin Birski , Krystyna Soszyńska , Anna Majdańska , Agata Ryfa , Marek Harat , Barbara Bojko

{"title":"Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS)","authors":"Joanna Bogusiewicz , Karol Jaroch , Jacek Furtak , Marcin Birski , Krystyna Soszyńska , Anna Majdańska , Agata Ryfa , Marek Harat , Barbara Bojko","doi":"10.1016/j.sampre.2024.100146","DOIUrl":"10.1016/j.sampre.2024.100146","url":null,"abstract":"<div><div>Potential biomarkers of cancerous alterations could be selected by profiling a wide range of analytes. For this purpose, analytical platforms enabling detailed analysis of different biological matrices are applied. However, after biomarker selection, it is essential to shorten the analysis time as much as possible to speed up the diagnostic process. Therefore, this study aimed to optimize and test the coated blade spray mass spectrometry (CBS-MS) method in analyzing potential biomarkers in brain tumor studies: acylcarnitine. Meningiomas with different mutation statuses in NF2 were studied due to the relation of NF2 mutation with the higher risk of malignant transformation and multiple meningiomas. The application of CBS-MS enabled the determination of acetylcarnitine concentration (AC C2:0) and propionylcarnitine (AC C3:0) in intact tumor tissue. However, it would be necessary to enlarge the study group to confirm the conclusions on the concentration of these analytes in NF2 mutant and wild-type meningiomas. Apart from qualitative analysis, the simultaneous detection of a wide range of acylcarnitines in untargeted analysis was also possible.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100146"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100149

Victor M. Amador-Luna, Miguel Herrero, Marta Jiménez de la Parra, Ángel Gómez Arribas, Elena Ibáñez, Lidia Montero

{"title":"Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES","authors":"Victor M. Amador-Luna, Miguel Herrero, Marta Jiménez de la Parra, Ángel Gómez Arribas, Elena Ibáñez, Lidia Montero","doi":"10.1016/j.sampre.2025.100149","DOIUrl":"10.1016/j.sampre.2025.100149","url":null,"abstract":"<div><div><em>Citrus aurantium</em>, also known as bitter orange, and the by-products obtained during its processing are a rich source of bioactive compounds. In particular, leaves from the tree pruning and from fruits harvesting are considered an agrifood-related waste with high valorization potential. Considering the wide variety of bioactive compounds present in the leaves (carotenoids, terpenes and phenolic compounds), this study is focused on the valorization of <em>C. aurantium</em> pruning waste through a sequential three-step extraction process using green extraction techniques, i.e. supercritical fluid extraction (SFE), followed by pressurized liquid extraction (PLE) using natural deep eutectic solvents (NADES), and an antisolvent extraction to recover the remaining bioactive compounds adsorbed to the NADES and extraction residues. In this sense, this is the first time that PLE using NADES followed by an antisolvent step to re-extract the compounds from the PLE residue is presented. Moreover, different protocols to efficiently remove the NADES from the PLE extract were also studied for the first time. Due to the different nature and bioactivity of the obtained extracts, the mixture of the three fractions was optimized to enhance its overall preventive potential against neurodegenerative diseases. Finally, its scalability to a semi-pilot scale was evaluated, giving rise to increased bioactive values of the blended extract.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100149"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100159

Teshome Degfie Beshah , Mariam Araby Fekry saad , Sally el Gazar , Mohamed A. Farag

{"title":"Curcuminoids: A multi-faceted review of green extraction methods and solubilization approaches to maximize their food and pharmaceutical applications","authors":"Teshome Degfie Beshah , Mariam Araby Fekry saad , Sally el Gazar , Mohamed A. Farag","doi":"10.1016/j.sampre.2025.100159","DOIUrl":"10.1016/j.sampre.2025.100159","url":null,"abstract":"<div><div>Curcuminoids, chief polyphenols in Curcuma longa L. rhizome have extensive culinary and medicinal applications. In medicine, curcuminoids exhibit potential health benefits including anticancer, antimicrobial, antitumor, antidiabetic, neuroprotective, antioxidant, and cardioprotective properties. Additionally, curcuminoids are commonly used in culinary as a spice, flavoring agent, pigment, and food additive. Considering the potential value of curcuminoids and their difficulty to be synthesized, the development of effective extraction and purification techniques for their recovery from natural sources seems warranted. To meet the demands of food and nutraceutical industries, an effective curcuminoids’ extraction process should adhere to green chemistry principles in order to ensure efficiency, safety, environmental sustainability, minimal contaminants, and cost-effectiveness. This review focuses on several curcuminoids’ separation methods including traditional techniques, such as Soxhlet, maceration, and solvent extraction, as well as green advanced technologies including ultrasound-assisted extraction, enzyme-assisted extraction, extractions via pressurized liquid, supercritical fluid, pulsed electric field, three-phase partition, and deep eutectic solvents. A comparison is presented among the different extraction methods highlighting their advantages and limitations to aid future users in deciding on the best method that suit their needs. Lastly, approaches reported on improving curcuminoids’ solubility are also presented as part of this study to enhance their bioavailability and ultimate efficacy.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100159"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Supramolecular Deep Eutectic Solvents based extraction for bioactive phenolic compounds recovery from olive pomace 基于可持续超分子深共晶溶剂的萃取技术，用于从橄榄渣中回收生物活性酚类化合物

IF 5.2

Advances in Sample Preparation Pub Date : 2025-02-01 DOI: 10.1016/j.sampre.2025.100166

G. Pietrangeli , S. Della Posta , E. D'Alessandro , S.M. Giannitelli , M. Trombetta , C. Maggi , L. De Gara , C. Fanali

{"title":"Sustainable Supramolecular Deep Eutectic Solvents based extraction for bioactive phenolic compounds recovery from olive pomace","authors":"G. Pietrangeli , S. Della Posta , E. D'Alessandro , S.M. Giannitelli , M. Trombetta , C. Maggi , L. De Gara , C. Fanali","doi":"10.1016/j.sampre.2025.100166","DOIUrl":"10.1016/j.sampre.2025.100166","url":null,"abstract":"<div><div>Olive oil industries produce a large quantity of by-product, such as wastewater and olive pomace, which are characterized by a high concentration of phenolic compounds, which can be recovered and eventually reused in cosmeceutical and nutraceutical fields. The recovery of bioactive molecules from waste is usually carried out by common of organic solvents. To respect the principles of green chemistry, other solvents such as Deep Eutectic Solvents (DESs) have been evaluated. DESs are sustainable solvents involved in sample preparation. Recently, DESs have also been evaluated as extraction solvent with the addition of β-cyclodextrins (β-CDs) which are cyclic oligosaccharide molecules obtained from the enzymatic degradation of starch, and their characteristics allow them to be selective toward certain analytes. These innovative solvents, called Supramolecular Deep Eutectic Solvents (SupraDESs), seem to be excellent green solvents for the extraction of phenolic compounds and are a sustainable alternative to conventional solvents. The aim of this work was to develop and optimize an analytical procedure for the extraction of phenolic compounds from olive pomace, using a SupraDES composed by ammonium acetate - lactic acid (in a molar ratio of 1:7) with the addition of a certain amount of β-cyclodextrins as extraction solvent. The optimized extraction procedure, defined through Box-Behnken Design, is based on the best extraction time of 22 min, temperature of 43°C, solid-to-liquid ratio of 1:48 (g:mL) and β-CDs concentration of 1.8 % (w/w). The qualitative profile of the extracted phenolic compounds was determined through high performance liquid chromatography coupled with mass spectrometry.</div></div>","PeriodicalId":100052,"journal":{"name":"Advances in Sample Preparation","volume":"13 ","pages":"Article 100166"},"PeriodicalIF":5.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0