材料科学最新文献

{"title":"Sequential-Photocuring-Assisted Transformation of Planar Multilayer Structures into Curved Geometries","authors":"Daihyun Hwang,Jeonghyo Lee,Yeonseo Lee,Yougyoung Lee,Sungjun Han,Hosun Lim,Jung Ah Lim,Heesuk Kim,Wonbin Hong,Min Sang Kwon","doi":"10.1021/acsami.6c13437","DOIUrl":"https://doi.org/10.1021/acsami.6c13437","url":null,"abstract":"The integration of functional electronic structures into curved geometries remains challenging, as conventional approaches rely on post-shaping or adhesive-assisted assembly that separate structure formation from shape definition. Here, we present a sequential-photocuring-assisted fabrication strategy that transforms planar multilayer structures into curved forms within a single material system. A wavelength-selective acrylate–epoxy resin is designed to create a deformable intermediate state under visible light, followed by a fixation-enabled final state through UV-triggered curing. A gradient-like curing strategy, involving time-dependent evolution of conversion during sequential irradiation, allows controlled partial epoxy conversion and provides both processability and subsequent reactivity. The second curing step induces simultaneous interfacial bonding and structural stiffening, enabling adhesive-free integration and fixation of the mold-imposed geometry. A multilayer patch antenna operating at 28 GHz is fabricated and transformed from planar to curved geometry while maintaining its performance. This approach provides a material-based framework for integrating planar-fabricated structures into three-dimensional form factors without thermoforming or adhesives.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"56 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprotonation Kinetics Engineering of Aramid Nanofiber Hydrogel Electrolytes for Aqueous Zinc-Ion Batteries","authors":"Yuseung Choi,Gilyong Shin,Jihun Lee,Sang Won Kim,Hoyeon Lee,Byeong Jun So,Hyeong Jun Kim,Ju Hwan Lee,Jei Gyeong Jeon,U Hyeok Choi,Hyunseong Shin,Tae June Kang","doi":"10.1021/acsami.6c16229","DOIUrl":"https://doi.org/10.1021/acsami.6c16229","url":null,"abstract":"Aqueous zinc-ion batteries are promising next-generation energy-storage systems owing to their intrinsic safety and cost-effectiveness. However, dendrite formation and parasitic reactions at Zn metal anodes limit long-term cycling stability. Here, aramid nanofiber (ANF) hydrogel electrolytes are engineered by controlling the acid identity and solution pH during reprotonation. These variables regulate reprotonation kinetics, thereby shaping hydrogen-bond formation, molecular ordering, and the through-thickness morphology of the ANF network. The selected ANF hydrogel electrolyte exhibits a Young’s modulus of 1.1 MPa while maintaining an ionic conductivity of 30.8 mS cm–1. Its mechanically robust and ionically conductive network promotes compact Zn deposition and resists dendrite penetration. Consequently, Zn||Zn symmetric cells sustain stable plating/stripping for over 2000 h at 1.0 mA cm–2 with an areal capacity of 1.0 mAh cm–2. Compared with conventional glass-fiber-based cells, Zn||hydrated vanadium oxide full cells also exhibit improved high-rate capacity retention and retain over 88% of their initial capacity after 2000 cycles at 1.0 A g–1. These findings establish reprotonation kinetics as a practical design parameter for balancing mechanical robustness, ion transport, and interfacial stability in hydrogel electrolytes for durable aqueous zinc-ion batteries.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"291 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Stimulus-Responsive Gold Nanorods for Synergistic Chemo–Photothermal Cancer Therapy","authors":"Maryam Deinavizadeh,ALI reza Kiasat,Roya Mirzajani,Fateme Khalili,Ashkan Zandi,Nasrin Hooshmand","doi":"10.1039/d6nr02234k","DOIUrl":"https://doi.org/10.1039/d6nr02234k","url":null,"abstract":"Cancer is a multifactorial disease characterized by a unique and dynamic tumor microenvironment (TME), along with disrupted tissue architecture and abnormal cellular organization. Conventional anticancer drugs often require high doses for systemic administration, leading to nonspecific tissue distribution and serious side effects. Nanomaterials have significantly impacted cancer treatment by enabling the loading of anticancer drugs into nanocarriers. These nanocarriers can minimize unnecessary systemic toxicity and provide sustained drug release in response to various exogenous (photo/light, temperature) or endogenous (pH, enzymes) stimuli. This approach has led to the development of environment-responsive nanocarriers, designed to ensure targeted delivery of anticancer drugs to specific lesion sites. These nanocarriers enable effective drug release, help overcome the biological barriers that limit conventional treatments, and reduce the required drug dose. Among cancer therapies, conventional chemotherapy (CHT) is a direct treatment method but often causes unintended side effects due to its nonspecific action on both tumor and normal cells. In contrast, patient-friendly photothermal therapy (PTT) offers the potential to treat tumors embedded in vital regions with minimal invasion, though it may not guarantee complete cancer removal. The combination of CHT and PTT, however, presents a promising approach for direct cancer treatment with reduced side effects. In this context, nanostructured materials such as gold nanorods, with optimized size and surface characteristics, play a crucial role in enhancing heating capacity and facilitating active or passive drug delivery to tumor sites. This review summarizes pioneering work on the synergistic combination of chemotherapy and photothermal therapy, with a focus on recent advances in stimulus-responsive nanocarriers for combinational cancer treatment. Additionally, we highlight strategies that enhance gold nanorod-assisted photothermal therapy through its integration with chemotherapeutic agents.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"18 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recyclable Poly(urethane-urea) Covalent Adaptable Network Foams via Catalyst-, Isocyanate-, and Additive-Free Synthesis","authors":"Jihong Lyu,&nbsp;Chanyeong Jeong,&nbsp;Jun Young Jo,&nbsp;Nam Jung Heo,&nbsp;Young Il Park,&nbsp;Hyocheol Jung,&nbsp;Hyoung Eun Bae,&nbsp;Hiep Dinh Le,&nbsp;Young-Jae Jin,&nbsp;Ji-Eun Jeong,&nbsp;Jin Chul Kim","doi":"10.1021/acsami.6c12906","DOIUrl":"10.1021/acsami.6c12906","url":null,"abstract":"<p>For decades, poly(urethane-urea) (PUU) foam production has relied on hazardous isocyanates and a complex array of external catalysts and blowing agents, resulting in chemically persistent materials that defy recycling. Herein, we break this convention by reporting the first-ever synthesis of high-performance PUU foams through an entirely autonomous, isocyanate-free, and additive-free pathway. By leveraging the ring-opening of thiazolidin-2-one with multifunctional amines, we establish a streamlined reaction that simultaneously constructs a covalent adaptable network (CAN) and triggers <em>in situ</em> CO₂ evolution. This chemistry bypasses traditional reagents; instead, internal thiol groups react with ethylene carbonate to drive foaming under entirely catalyst-free conditions. By precisely tuning the tris(2-aminoethyl)amine ratio, we synchronize gas expansion with matrix vitrification, overcoming the structural collapse typical of nontraditional systems. The resulting foams feature hindered urea linkages that impart dissociative CAN behavior, enabling full chemical reprocessability and structural recovery over multiple cycles without compromising mechanical integrity. With an open-cell architecture and acoustic performance comparable to those of the tested commercial reference materials under the present measurement conditions, this work provides a promising strategy for designing circular cellular materials that contribute to a zero-waste chemical economy.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56092–56104"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core-Shell Microneedle Patches Co-Loaded with Gymnema Sylvestre Extract and IL-4 Accelerate Diabetic Wound Repair via Inflammatory Microenvironment Remodeling","authors":"Jingye Yao,&nbsp;Qingrong Zhang,&nbsp;Mengnan Zhang,&nbsp;Zhao Zhou,&nbsp;Shentian Zou,&nbsp;Shixuan Chen,&nbsp;Yuhui Cai,&nbsp;Yi Zhang","doi":"10.1021/acsami.6c14857","DOIUrl":"10.1021/acsami.6c14857","url":null,"abstract":"<p>Chronic wound healing remains a persistent challenge clinically, particularly in diabetic wounds, where hyperglycemia drives sustained activation of the AGE–RAGE-associated signaling within the wound bed, precipitating excessive ROS generation and persistent inflammation that together stall tissue repair and erode quality of life. To address this, we developed a core–shell microneedle (GS + IL-4@MN) patch loading Gymnema sylvestre (GS) extract and interleukin-4 (IL-4) as a promising therapeutic strategy. The patch comprised a 10 × 10 array of conical needles and the optimized shell-loading concentration of GS was determined to be 1.0 mg/mL. The GS-loaded outer shell can suppress the release of pro-inflammatory mediators, scavenge ROS, and strengthen antioxidant defenses, thereby attenuating local inflammation; the IL-4-encapsulated core induces macrophage polarization toward the M2 phenotype, mitigates the pro-inflammatory microenvironment, and modulates T-cell immunity, while enhancing cellular proliferation and migration to support tissue regeneration. In diabetic wound models, GS + IL-4@MN achieved wound-closure rates of 64.72 ± 6.3% at day 3 and 85.80 ± 3.6% at day 7, and re-epithelialization reached 91.52 ± 2.1% by day 14. Moreover, collagen deposition increased to 79.38 ± 4.3%, CD31-positive neovascularization reached 70.50 ± 3.7%, and the M1/M2 ratio decreased to 0.3, indicating marked inflammatory resolution and regenerative activation. In summary, this core–shell MN system achieves multidimensional regulation of the pathological microenvironment of diabetic wounds through a dual mechanism: outer-layer inflammatory suppression and inner-layer microenvironment reset, and offers a new avenue for promoting diabetic wound healing.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55930–55945"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BODIPY-Based Fluorescent Probes for Selected Hazardous Chemicals: Multilevel Regulation of Sensing Performance","authors":"Gege Wang,&nbsp;Min Qiao,&nbsp;Yujia Li,&nbsp;Yuyang Chen,&nbsp;Deqing Baima,&nbsp;Qi Zhang,&nbsp;Liping Ding,&nbsp;Xiaolin Zhu,&nbsp;Yu Fang","doi":"10.1021/acsami.6c17906","DOIUrl":"10.1021/acsami.6c17906","url":null,"abstract":"<p>The rapid and reliable detection of hazardous chemicals in complex environments remains an important challenge in fluorescence sensing. BODIPY dyes and related boron-difluoride fluorophores have attracted considerable attention because of their excellent photophysical properties and highly tunable molecular structures. However, sensing performance depends not only on analyte recognition but also on excited-state processes, intermolecular interactions, aggregation behavior, analyte transport, and practical signal readout. This review examines BODIPY-based fluorescent sensing of selected hazardous chemicals at the molecular level, supramolecular and aggregated-state level, and sensing material and device level, focusing on how regulation at different levels addresses different performance limitations. At the molecular level, recognition unit design, conformational regulation, and boron-center transformation regulate analyte recognition and signal transduction. At the supramolecular and aggregated-state level, noncovalent interactions, aggregation-state regulation, and molecular packing influence emission behavior and signal stability. At the sensing material and device level, interfacial and transport regulation, sensing material construction, and device integration and signal readout improve analyte accessibility and practical detection performance. This review provides a systematic framework for understanding the factors that govern BODIPY-based fluorescence sensing. This multilevel classification facilitates the identification of major factors limiting sensing performance and the corresponding regulation strategies, thereby providing guidance for the rational design and optimization of BODIPY-based fluorescent sensing systems.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55735–55752"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ionic liquid-integrated poly(vinylidene fluoride--hexafluoropropylene)/LiLaZrO composite membrane for high-performance quasi-solid-state Li-ion batteries","authors":"Ai-Yin Wang,Chun-Han Kuo,Hao-Yu Liu,Feng-Qi Lu,Yen-Lin Chen,Chien-Hao Yeh,Tseng-Lung Chang,Ching-Kai Kao,Han-Yi Chen","doi":"10.1039/d6nr02835g","DOIUrl":"https://doi.org/10.1039/d6nr02835g","url":null,"abstract":"Lithium-ion batteries (LIBs) with organic liquid electrolytes face safety and stability challenges. Solid-state electrolytes are promising but hindered by low ionic conductivity and poor interfacial contact. This study demonstrates an integrated additive strategy to enhance the performance of composite polymer electrolytes (CPEs). By incorporating a dispersant poly(4-styrenesulfonic acid) lithium salt (PSSLi), a plasticizer (succinonitrile, SN), and an ionic liquid (N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide, Pyr14TFSI) into a (poly(vinylidene fluoride-co-hexafluoropropylene), PVDF-HFP)/Li7La3Zr2O12 (LLZO) polymer matrix, a multicomponent hybrid electrolyte system was developed. The addition of SN and Pyr14TFSI effectively disrupts the polymer crystallinity and reduces interfacial impedance, facilitating efficient lithium-ion transport. As a result, the optimized CPE achieves an ionic conductivity of 4.40 × 10−4 S cm−1 at room temperature. The LiFePO4 (LFP)//Li cell delivers an initial specific capacity of 157 mAh g−1, demonstrating an excellent capacity retention of 95% after 100 cycles at 0.1C and room temperature. Moreover, the assembled commercial LiNi0.8Co0.1Mn0.1O2 (NCM-811)//SiO@C full cell exhibits an impressive specific capacity of 188 mAh g−1, retaining 74.4% of its capacity under identical conditions. These findings underscore the potential of this multicomponent system for high-performance quasi-solid-state battery applications.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"35 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divide and Conquer Strategy Using Piezoelectric Nanofiber Scaffolds for Stage-Specific Delivery of Bone-Targeted Exosome Mimetics with Ago/AntagomiR-126","authors":"Jeong In Kim,Subin Park,Soonchul Lee","doi":"10.1021/acsnano.6c10518","DOIUrl":"https://doi.org/10.1021/acsnano.6c10518","url":null,"abstract":"Bone regeneration is a temporally regulated process requiring stage-specific biochemical cues and biomechanical stimulation; however, current scaffold-based delivery systems largely rely on passive release and fail to adapt to the dynamic healing phases. While previous PVDF-based scaffolds have focused on enhancing piezoelectric output or osteoconductive properties, they primarily function as passive materials without the dynamic regulation of therapeutic activity. Here, we present a multifunctional piezoelectric scaffold that enables mechanically triggered, temporally controlled delivery of bone-targeted exosome mimetics (EMs) loaded with AgomiR or AntagomiR-126. The scaffold features a three-dimensional piezoelectric architecture that generates electromechanical activation under physiological loading, allowing for coupling between mechanical stimulation and therapeutic release. In addition, these components are functionally integrated to coordinate phase-specific miRNA activity during the repair. Alendronate-functionalized EMs enable bone-selective localization, while AgomiR-126 promotes early angiogenesis and progenitor recruitment and AntagomiR-126 enhances late-stage osteogenic differentiation. In vivo studies demonstrated that this system significantly improved bone repair. Rather than introducing a new component, this work establishes a mechanically gated, temporally programmed miRNA delivery strategy for phase-specific bone regeneration.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"75 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Bioadhesives for Gastrointestinal Hemostasis and Healing: Integrating Artificial Intelligence for Precision Design and Application","authors":"Menglu Wu,Xianglong Xing,Xiang Ling,Juncen Zhou,Malcolm Xing,Donghui Zhu","doi":"10.1021/acsnano.6c13279","DOIUrl":"https://doi.org/10.1021/acsnano.6c13279","url":null,"abstract":"Gastrointestinal (GI) bleeding and mucosal injury remain clinically challenging because most bioadhesives lose performance under acidic, enzymatic, and peristaltic conditions. Nanotechnology has advanced adhesive design by enhancing mechanical integrity, degradation control, and antimicrobial activity; however, translating these gains into consistently favorable clinical outcomes is still difficult. Artificial intelligence (AI) offers a route to accelerate and derisk development. Here, we identify predictive, multiobjective materials design as the AI domain most critical for GI nanobioadhesives because adhesion, hemostasis, degradation, biosafety, and healing must be optimized simultaneously. Predictive modeling, molecular simulations, and high-throughput experimentation enable rational control of adhesion strength, degradation kinetics, and biocompatibility, while machine-learning models expedite the discovery of optimal polymeric nanoparticle formulations. Emerging strategies such as digital twins and closed-loop optimization further support patient-specific and adaptive adhesive systems. By integrating AI-guided design with nanotechnology platforms, next-generation GI bioadhesives could unify rapid hemostasis, antimicrobial protection, and regenerative functions, thereby improving reliability and clinical translation. This review outlines the synergy between AI and nanotechnology and highlights priorities for advancing GI adhesive therapies from bench to bedside.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"12 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-Activated ROS/NO Cascade Nanocomposite Rewires Bacterial Redox Defense for Synergistic Eradication of Pseudomonas aeruginosa Wound Infection","authors":"Feng-xia Liu,Lin Qu,Ting-ting Chen,Rong Huang","doi":"10.1021/acsami.6c17153","DOIUrl":"https://doi.org/10.1021/acsami.6c17153","url":null,"abstract":"Pseudomonas aeruginosa wound infections remain difficult to eradicate because biofilm formation and bacterial redox-adaptive defenses weaken antibacterial efficacy and delay tissue repair. In this study, we reported a near-infrared (NIR)-activated reactive oxygen species (ROS)/ nitric oxide (NO) cascade nanocomposite, UCeSi-L@CA, designed to amplify oxidative/nitrosative antibacterial stress while promoting infected wound healing. UCeSi-L@CA was constructed from Ce6-loaded mesoporous silica-coated upconversion nanoparticles, with L-arginine conjugated through surface carboxyl groups and cinnamaldehyde loaded into the mesopores. Upon NIR irradiation, upconversion nanoparticles activated Ce6 to generate abundant ROS. Cinnamaldehyde exerted direct antibacterial activity and inhibited glutathione-mediated ROS scavenging, thereby sustaining ROS accumulation and weakening bacterial antioxidant defense. The accumulated ROS further triggered NO production from L-arginine, establishing a ROS/NO cascade in which ROS and NO cooperatively damaged bacterial membranes, enhanced lipid peroxidation, and induced efficient bacterial killing. Beyond antibacterial activity, NO also contributed to infected tissue repair. In vitro, UCeSi-L@CA + NIR showed excellent killing against planktonic P. aeruginosa, effectively inhibited biofilm formation, eradicated bacteria within established biofilms, and suppressed biofilm regrowth. In the P. aeruginosa-infected wound model, UCeSi-L@CA + NIR markedly reduced local bacterial burden, attenuated infection-associated inflammation, accelerated wound closure, and promoted tissue repair, with favorable biocompatibility in vitro and in vivo. This nanocomposite presents a non-antibiotic nanotherapeutic strategy integrating NIR-triggered ROS generation, cinnamaldehyde-mediated GSH-defense inhibition, and L-arginine-derived NO release for treating refractory biofilm-associated wound infections.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"56 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}