Advanced Materials Interfaces最新文献

Culinary Chemistry as a Platform for Interfacial Materials Design 烹饪化学作为界面材料设计的平台

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-14 DOI: 10.1002/admi.70705

Josep Moreno, I. Brian Becerril-Castro, Irene Calderon-Gonzalez, Jaslyn Ru Ting Chen, Zhiming Wang, Alexander O. Govorov, José Manuel Romo-Herrera, Neus Feliu, Wolfgang J. Parak, Miguel A. Correa-Duarte, In Yee Phang, Xing Yi Ling, Ramón A. Alvarez-Puebla

{"title":"Culinary Chemistry as a Platform for Interfacial Materials Design","authors":"Josep Moreno, I. Brian Becerril-Castro, Irene Calderon-Gonzalez, Jaslyn Ru Ting Chen, Zhiming Wang, Alexander O. Govorov, José Manuel Romo-Herrera, Neus Feliu, Wolfgang J. Parak, Miguel A. Correa-Duarte, In Yee Phang, Xing Yi Ling, Ramón A. Alvarez-Puebla","doi":"10.1002/admi.70705","DOIUrl":"https://doi.org/10.1002/admi.70705","url":null,"abstract":"This Review examines culinary systems as experimentally accessible models of interfacial materials design. Culinary operations, including emulsification, foaming, gelation, spherification, controlled heating, smoking, and dehydration, govern gas-liquid, oil-water, solid-liquid, polymer-nanoparticle, and hydrogel-analyte interfaces, thereby coupling microstructure to transport, mechanics, optical response, and sensory performance. We then analyze how programmable heated high-shear mixers, pressure cookers, food-derived hydrocolloids, protein fibrils, metal-phenolic networks, anthocyanins, and plasmonic nanostructures can support functional materials, sensing, and potentially more sustainable processing. Original Au/agar-agar and Ag/agar-agar experiments are presented as bounded proof-of-concept demonstrations of this translation. The Review closes by identifying constraints in safety classification, regulatory acceptance, reproducibility, stability, scale-up, and end-of-life assessment. This interface-centered framework positions culinary chemistry not merely as applied chemistry, but as a source of processing concepts and structure-property relationships for advanced materials.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose Surface Modification Effects on Equilibrium and Non-Equilibrium Wetting by Water 纤维素表面改性对水分平衡和非平衡润湿的影响

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-07 DOI: 10.1002/admi.70698

Jakob Wohlert, Lars Berglund

{"title":"Cellulose Surface Modification Effects on Equilibrium and Non-Equilibrium Wetting by Water","authors":"Jakob Wohlert, Lars Berglund","doi":"10.1002/admi.70698","DOIUrl":"https://doi.org/10.1002/admi.70698","url":null,"abstract":"Chemical modification is an important route to tuning interactions between nanocellulose and its surrounding media. Specifically, it affects the wetting characteristics, which in turn affect water transport, moisture sensitivity, and liquid processability. Wetting at the nanoscale is difficult to characterize experimentally, which is why molecular simulation is an attractive method for investigating these phenomena. However, simulations are sensitive to choice of interaction parameters and methodology. Here, we investigate wetting of both native and surface modified (acetylated and TEMPO oxidized) cellulose substrates by water in molecular dynamics simulations. Two complementary methods are compared: simulation of explicit droplet spreading, and an indirect method where the equilibrium wetting angle is given by the solid-liquid work of adhesion computed from the potential of mean force. In addition, the dynamics of wetting is analyzed within the framework of molecular kinetic theory. Our results clearly show the effects of surface modification on both the equilibrium contact angle and the wetting dynamics where hydrophobization decreases, and oxidation increases, the wetting efficiency. In addition, it is shown that contact line friction is the dominating energy dissipation mechanism for cellulose wetting at the nanometer scale.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Reusable Nanocomposite Membranes for Highly Efficient Arsenite and Arsenate Dual Removal From Water” 更正“高效去除水中砷酸盐和砷酸盐的可重复使用纳米复合膜”

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-07 DOI: 10.1002/admi.70689

引用次数: 0

Ionic Liquid (IL) Compatibilization of Macropore-Infused Nanocomposite Emulsion Thermosets (MINETs) for Structural Ion Transport 离子液体（IL）对大孔注入纳米复合乳液热固性材料（MINETs）结构离子传输的增容作用

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-05 DOI: 10.1002/admi.70681

Bryan Llumiquinga, Iris You, Nare Cho, Madhuri Deb, Jordan C. Pierce, Kevin M. Miller, Jonathan P. Singer

{"title":"Ionic Liquid (IL) Compatibilization of Macropore-Infused Nanocomposite Emulsion Thermosets (MINETs) for Structural Ion Transport","authors":"Bryan Llumiquinga, Iris You, Nare Cho, Madhuri Deb, Jordan C. Pierce, Kevin M. Miller, Jonathan P. Singer","doi":"10.1002/admi.70681","DOIUrl":"https://doi.org/10.1002/admi.70681","url":null,"abstract":"Macropore-infused nanocomposite emulsion thermosets (MINETs) offer a novel approach for multifunctional monoliths and carbon fiber composites (CFCs), leveraging tunable porosity and material compatibility to meet the demands of aerospace and energy applications. Using 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF4) and a propylene glycol-ionic liquid (IL) triblock copolymer surfactant, we successfully stabilized an epoxy-IL emulsion with compatibility with particles such as silica, super-activated carbon (SAC), and graphene. Optimal surfactant levels (5.11% for SAC and graphene and 3.46% for silica) facilitated continuous IL phases, enhancing porosity and ionic conductivity, as confirmed by mass loss, mercury porosimetry, and ionic conductivity analyses. SEM revealed well-defined nanostructures, while resin content adjustments highlighted a balance between mechanical integrity and conductivity. These advancements provide a strong foundation for integrating IL-MINETs into multifunctional composites for structural power storage and flame-resistant materials, with significant potential in aerospace and renewable energy systems. Ongoing work focuses on fluorinated IL surfactants to enhance conductivity and stability, as well as designing layered MINET composites for multifunctional applications.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-05 DOI: 10.1002/admi.70676

Harshal V. Barkale, Anakhi Hazarika, Nilanjan Dey

{"title":"Mapping Correlated Environmental Landscapes in the Fluorescence Response of a Pyrenylated Charge-Transfer Probe via Data-Driven Nonlinear Regression","authors":"Harshal V. Barkale, Anakhi Hazarika, Nilanjan Dey","doi":"10.1002/admi.70676","DOIUrl":"https://doi.org/10.1002/admi.70676","url":null,"abstract":"Here, we report the design and detailed photophysical investigation of a pyrene aniline-based donor–acceptor probe (compound 1) that displays pronounced sensitivity to multiple environmental factors. Steady-state and time-resolved fluorescence studies reveal strong solvatochromism, viscosity-enhanced emission following the Förster Hoffmann relationship over a broad range (≈1.9–100 cP), concentration-dependent aggregation effects, and thermally activated fluorescence quenching without changes in the emissive electronic state. Dynamic light scattering and density functional theory calculations establish a sterically twisted donor–acceptor architecture that supports intramolecular charge transfer while remaining highly responsive to microenvironmental constraints. Building on this experimentally validated framework, machine learning (ML) was employed as a computational extension of fluorescence spectroscopy to reconstruct continuous fluorescence–environment relationships from discrete datasets. Nonlinear regression models, particularly random forest and Gaussian process regression (GPR), accurately capture parameter-specific response topologies, outperforming linear approaches. Correlated viscosity with temperature and viscosity with concentration intensity maps reveal regime-dependent fluorescence behavior that cannot be inferred from single-parameter trends alone. Point-wise experimental validation confirms agreement in relative intensity ordering under combined parameter variation. Together, this work demonstrates a data-curated strategy for integrating supramolecular photophysics with ML, enabling physically consistent interpretation of complex fluorescence responses without extrapolation beyond experimental control.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interface Engineering of Porous Transport Layer-Catalyst Layer in Proton Exchange Membrane Water Electrolyzers: A Comprehensive Review 质子交换膜水电解槽多孔传输层-催化剂层界面工程综述

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-06 DOI: 10.1002/admi.70684

Aobo Wan, Zhengkai Tu

{"title":"Interface Engineering of Porous Transport Layer-Catalyst Layer in Proton Exchange Membrane Water Electrolyzers: A Comprehensive Review","authors":"Aobo Wan, Zhengkai Tu","doi":"10.1002/admi.70684","DOIUrl":"https://doi.org/10.1002/admi.70684","url":null,"abstract":"A proton exchange membrane water electrolyzer (PEMWE) represents one of the most promising technologies for green hydrogen production. Within the membrane electrode assembly (MEA), the interface between the porous transport layer (PTL) and the catalyst layer (CL) exerts a decisive influence on overall electrolyzer performance. The PTL–CL interface governs not only electron conduction efficiency and ohmic contact resistance, but also proton transport, oxygen bubble evacuation, liquid water supply, and the utilization of catalytically active sites. This review systematically examines the functional roles and resistance sources at the PTL–CL interface, and surveys recent advances in noble metal and non-noble metal coatings, mechanical and chemical surface treatments, assembly compression optimization, microporous layer (MPL) and gradient porous structures, wettability engineering, and CL microstructure and composition optimization. Further discussion addresses future challenges including interfacial durability under ultra-low iridium (Ir) loading, standardization of accelerated stress test (AST) protocols, and scale-up manufacturing and engineering integration. This review aims to provide guidance for the design of high-performance, low-cost PTL–CL interfaces with practical scale-up potential in PEMWE.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Where Precursor Loading Stops Making a Difference: Resolving an Operational Infiltration Limit for Nanoparticle Synthesis Using Dual Quantification of Reverse Micelle Nanoreactors 前驱体负载停止产生差异：解决使用双定量反胶束纳米反应器的纳米颗粒合成的操作渗透限制

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-07 DOI: 10.1002/admi.70682

Linan Cui, Pedro Q. Oliveira, Kyla N. Sask, Ayse Z. Turak

{"title":"Where Precursor Loading Stops Making a Difference: Resolving an Operational Infiltration Limit for Nanoparticle Synthesis Using Dual Quantification of Reverse Micelle Nanoreactors","authors":"Linan Cui, Pedro Q. Oliveira, Kyla N. Sask, Ayse Z. Turak","doi":"10.1002/admi.70682","DOIUrl":"https://doi.org/10.1002/admi.70682","url":null,"abstract":"Achieving precise control over nanoparticle formation remains a fundamental challenge in nanofabrication, particularly for template-mediated synthesis. Reverse micelle deposition (RMD), using diblock copolymer nanoreactors, enables the synthesis of highly uniform nanoparticles with tunable dimensions. Directly quantifying precursor loading within these nanoreactors remains challenging, as existing techniques are often indirect or chemically specific. Here, we combine PeakForce Quantitative Nanomechanics (QNM) and Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) to independently examine precursor loading of poly(styrene)-b-poly(2-vinyl pyridine) (PS-b-P2VP) reverse micelles. Despite probing different physical responses, both techniques exhibit the same loading-dependent evolution, reaching a common plateau at a nominal loading ratio of ∼0.6. AFM measurements of etched nanoparticles reveal a corresponding plateau in particle size, indicating that nanoparticle formation exhibits the same loading threshold. Rather than simply demonstrating that these quantities vary with precursor loading, the independent convergence of nanomechanical, mass, and nanoparticle size measurements on the same loading threshold establishes a quantitative framework for identifying operational precursor loading limits in reverse micelle nanoreactors. As it relies on generic physical responses rather than chemically specific detection, this dual-quantification framework should be broadly transferable across templated nanoparticle synthesis, providing an experimentally accessible strategy for comparing precursor loading behaviors and optimizing synthesis conditions.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rubber-Glass-Crystal Triple Phase Transition in Polyacrylamide Hydrogels and Environment-Adaptive Shape Memory Effect 聚丙烯酰胺水凝胶中的橡胶-玻璃晶体三相转变及环境自适应形状记忆效应

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-07 DOI: 10.1002/admi.70697

Shuai Xu, Han Li, Wenjing Lu, Yiheng Xue, Jincheng Lei, Linchun He, Yu Chai, Zishun Liu

{"title":"Rubber-Glass-Crystal Triple Phase Transition in Polyacrylamide Hydrogels and Environment-Adaptive Shape Memory Effect","authors":"Shuai Xu, Han Li, Wenjing Lu, Yiheng Xue, Jincheng Lei, Linchun He, Yu Chai, Zishun Liu","doi":"10.1002/admi.70697","DOIUrl":"https://doi.org/10.1002/admi.70697","url":null,"abstract":"Phase transition dramatically affects the stretchability, conductivity, and other key properties of hydrogels, thereby limiting their application in various fields. Precise control of the phase transition is of profound significance to advance their applications. By combining in situ and ex situ experiments and molecular simulations, this study reveals that the polymer networks in polyacrylamide hydrogels markedly suppress water crystallization, while the water in turn hinders the glass transition of polymer networks. We demonstrate that, driven by changes in hydrogen-bonding interaction mode and free volume, a hydrogel can switch among the rubbery, glassy, and crystalline states under the coupled temperature and moisture stimuli. Leveraging the Rubber-Glass-Crystal transitions, we propose an environment-adaptive shape memory strategy for hydrogels. Notably, this shape memory behavior is programmed by temperature and moisture, rather than by manual mechanical programming as in conventional shape memory polymers, and the shape recovery occurs extremely rapidly, in contrast to existing water-triggered systems that depend on slow solvent diffusion. In addition, a constitutive theory is developed to capture the glass-rubber-crystal transitions and to guide the design of soft machines. This work deepens the fundamental understanding of hydrogel phase transitions and paves the way for their application in intelligent actuators and sensors.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications 石墨烯层作为功能性生物材料。从制造和表征到生物应用

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-09-30 DOI: 10.1002/admi.70585

Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei

{"title":"Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications","authors":"Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei","doi":"10.1002/admi.70585","DOIUrl":"https://doi.org/10.1002/admi.70585","url":null,"abstract":"The present study explores the influence of graphene layer number on the adhesion, proliferation, and differentiation of L-929 fibroblast cells. Double- and multi-layer graphene was fabricated using CVD on Cu and then transferred to other types of substrates by the electrochemical delamination method. Scanning electron microscopy and Raman spectroscopy confirmed the formation of a uniform and continuous graphene film. Four-point probe measurement of double-layer graphene revealed a higher sheet resistance. SEM and fluorescence microscopy results revealed a higher density of L-929 cells on multi-layer graphene, suggesting that multilayer graphene supported a significantly greater number of cells compared with double-layer graphene. Immunofluorescence assays, focusing on vinculin and α-SMA detection, reveal a robust cellular adhesion and extensive proliferation on the multi-layer substrate and suggest that this has the ability to stimulate the transformation of fibroblasts into myofibroblasts, highlighting its beneficial impact on cellular function. This analysis suggests an innovative approach that demonstrates that layer-number-dependent structural features of pristine graphene directly modulate cell adhesion and cytoskeletal behavior, highlighting multilayer graphene as a more effective biointerface for early fibroblast activation.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody-Precomplexed Hemagglutinin Constructs Multivalently Bind Sialylated Glycan Receptors with Variable Valencies 抗体预络合血凝素构建多价结合可变价唾液化聚糖受体

IF 4.5 3区材料科学

Advanced Materials Interfaces Pub Date : 2026-11-06 Epub Date: 2026-10-05 DOI: 10.1002/admi.70691

Daniel Y. E. L. Tambuwun, María Ríos Carrasco, Elif Uslu, Geert-Jan P. H. Boons, Nadia J. Mokiem, Albert J. R. Heck, Victor C. Yin, Robert P. de Vries, Jurriaan Huskens

{"title":"Antibody-Precomplexed Hemagglutinin Constructs Multivalently Bind Sialylated Glycan Receptors with Variable Valencies","authors":"Daniel Y. E. L. Tambuwun, María Ríos Carrasco, Elif Uslu, Geert-Jan P. H. Boons, Nadia J. Mokiem, Albert J. R. Heck, Victor C. Yin, Robert P. de Vries, Jurriaan Huskens","doi":"10.1002/admi.70691","DOIUrl":"https://doi.org/10.1002/admi.70691","url":null,"abstract":"Antibody precomplexation is a well-known method to enhance the valency and affinity of hemagglutinin (HA), thus allowing their use in various tests, such as hemagglutination assays. How antibody precomplexation regulates the valency of HAs from monovalent to multivalent and thus enhances their affinity, however, remains elusive. Here, we analyze the binding of antibody-precomplexed HA constructs to glycan-containing supported lipid bilayers (SLBs) with controlled receptor density to assess the effects of valency on affinity. Although precomplexation of HA increases hemagglutination with red blood cells (RBCs), mass photometry data shows a heterogeneous mixture of components with variable HA valencies. The ΔDn/-ΔFn ratios (i.e., the acoustic ratios) from quartz crystal microbalance with dissipation monitoring (QCM-D) confirm the heterogeneity of complexes also at the surface. Using QCM-D combined in situ with spectroscopic ellipsometry (SE), we observed an avidity enhancement of precomplexed HA from the micromolar to the nanomolar range. Despite the distribution in valencies, precomplexed HA shows superselective binding responses to varying surface receptor densities. Orientation of the binding sites and the rigidity of the precomplexed HA structures affect the binding in different ways depending on the presentation of the receptors, i.e., 2D on a flat surface and 3D in solution.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"13 21","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.70691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0