Advanced Science最新文献

{"title":"Voltage-Reconfigurable Magneto-Ionic Nanolayers in Dot Arrays for Probabilistic, Materials-Engineered Security Primitives","authors":"Irena Spasojevic,&nbsp;Federica Celegato,&nbsp;Alessandro Magni,&nbsp;Paola Tiberto,&nbsp;Jordi Sort","doi":"10.1002/advs.76814","DOIUrl":"10.1002/advs.76814","url":null,"abstract":"<p>The Big Data revolution demands advanced security solutions that are energy-efficient, scalable, and resistant to emerging threats. Conventional encryption, based on algorithmic complexity, is resource-intensive and increasingly vulnerable. To safeguard sensitive information, it is essential to develop innovative anti-hacking and anti-counterfeiting technologies that provide material-level protection embedded at the smallest length scales. Here, we present a <i>selective magneto-ionic strategy for hardware-level security</i> that exploits voltage-controlled N^3– ion migration within pre-defined paramagnetic FeCoN dot arrays. This enables the creation of reconfigurable sub-15 nm ferromagnetic sublayers with deterministic or probabilistic (single-domain↔vortex) states and voltage-tunable probabilities. These states facilitate robust magnetic fingerprinting and constitute self-protected primitives suitable for physical unclonable functions and in-memory probabilistic inference, while their stochastic orientation and chirality provide a platform for true random number generation. This architecture combines tamper resistance, low power consumption, and scalability, representing a significant leap toward next-generation hardware security rooted in ion-spin control at the nanoscale.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9-CD36 Axis in Obesity-Associated Pancreatic Adenocarcinoma","authors":"Kaidi Chen,&nbsp;Rong Chen,&nbsp;Wei Li,&nbsp;Bin Song,&nbsp;Ruiying Zhang,&nbsp;Lewei Dai,&nbsp;Yuwei Qi,&nbsp;Ruqian Chen,&nbsp;Yifan Xu,&nbsp;Hangbin Li,&nbsp;Jingyi Huang,&nbsp;Fangping Wu,&nbsp;Jianan Peng,&nbsp;Xinyu Wang,&nbsp;Yang Xiong,&nbsp;Chaofeng Mu,&nbsp;Guilin Cheng,&nbsp;Zhaoshen Li,&nbsp;Shanming Ruan,&nbsp;Lei Huang,&nbsp;Mancang Gu","doi":"10.1002/advs.202515759","DOIUrl":"10.1002/advs.202515759","url":null,"abstract":"<p>Pancreatic adenocarcinoma (PAAD), characterized by an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, exhibits a dismal prognosis further exacerbated by obesity. This study demonstrates the potent immunomodulatory and antitumor effects of coixenolide, a bioactive fatty acid ester from Coix lacryma-jobi L., particularly in obesity-associated PAAD. Utilizing high-fat diet (HFD)-fed mouse models, we found that coixenolide significantly inhibited tumor growth in HFD mice compared to control diet (CD) mice, correlating with enhanced intra-tumoral CD8⁺ T cell infiltration and cytotoxicity, reduced regulatory T cells (Tregs), and increased tumor cell apoptosis. Single-cell RNA sequencing (scRNA-seq) of PAAD tissues revealed that coixenolide specifically expanded and activated cytotoxic CD8⁺ T cells within the TME of HFD mice. Further analysis identified distinct malignant epithelial cell clusters enriched in HFD tumors, characterized by high expression of <i>S100a8/a9</i> and stemness potential. Coixenolide treatment significantly reduced these <i>S100a8/a9</i>-expressing tumor cell populations and suppressed <i>S100a8/a9</i> protein expression and secretion. Cell–cell communication analysis and functional assays revealed that tumor cell-derived <i>S100a8/a9</i> interacted with <i>Cd36</i> on CD8⁺ T cells. This interaction promoted CD36-mediated fatty acid uptake, leading to lipid peroxidation, ferroptosis, and functional exhaustion of CD8⁺ T cells. Coixenolide disrupted this axis by inhibiting tumor cell <i>S100a8/a9</i>, thereby downregulating CD36 on CD8⁺ T cells, reducing lipid peroxidation and ferroptosis, and restoring CD8⁺ T cell cytotoxicity. Genetic knockout (<i>S100a9</i> KO) of tumor cells mimicked coixenolide's effects, enhancing CD8⁺ T cell function and suppressing tumor growth in vivo, especially in HFD mice. Clinical data confirmed elevated S100A8/A9 expression in human PAAD tumors correlated with poor survival, advanced stage, and higher histological grade, and scRNA-seq of patient samples showed S100A8/A9 expression in malignant ductal cells. Collectively, these results identify coixenolide as an immune-metabolic modulator that attenuates obesity-driven immunosuppression in PAAD at least in significant part through inhibition of the S100A8/A9-CD36 axis, with lipid peroxidation and ferroptosis of CD8⁺ T cells reduced. Other mechanisms potentially involving regulatory T cells warrant further investigation in the future. These findings suggest S100A8/A9-CD36-mediated intercellular crosstalk as a therapeutically actionable immune-metabolic vulnerability in obesity-associated PAAD.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydopamine-Wool Textiles for Sustainable Interfacial Solar Vapor Generation","authors":"Kyuin Park,&nbsp;Jintong Gao,&nbsp;Hansadi Jayamaha,&nbsp;Yipu Wang,&nbsp;Mia Bressler,&nbsp;Lenan Zhang,&nbsp;Larissa M. Shepherd","doi":"10.1002/advs.77609","DOIUrl":"10.1002/advs.77609","url":null,"abstract":"<p>Interfacial solar vapor generation (ISVG), which harnesses sunlight for water distillation, presents a promising strategy to address global water scarcity. While conventional 3D evaporators offer high evaporation performance, their widespread implementation remains constrained by material selection, cost, and fabrication methods. Herein, we present a nature-inspired, polydopamine (PDA)-dyed wool textile as a 2.5D evaporator for ISVG, leveraging its double-sided evaporating surfaces to maximize overall evaporation performance. The inherent fibrous architecture of wool textiles enables efficient water transport via natural capillary and exhibits effective solar absorption through photothermal PDA dyeing. The hierarchical nanostructure on micro-scale fibers, created by subsequent plasma etching, further amplifies the light trapping and moisture wicking capabilities. Under 1-Sun illumination, the PDA-wool and ultrablack PDA-wool textiles achieve evaporation rates of 2.21 and 2.43 kg/m²/h, respectively. In modeled calculations, both outperform the commercial baseline, with ultrablack-wool exceling in low-solar regions. The all-natural composition eliminates concerns regarding the leaching of microplastics or hazardous nanomaterials. Furthermore, the system maintains a stable evaporation rate for 10 h of continuous operation without salt-accumulation. This approach opens new opportunities for natural textiles and offers a cost-effective route toward deployment of textile-based solar-driven water purification systems with strong practical viability in off-grid and socially vulnerable communities.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion","authors":"Sanjana Srikant,&nbsp;Pouyan Keshavarz Motamed,&nbsp;Thomas Borrillo,&nbsp;Lielle Ronen,&nbsp;Gabriel Siebiger,&nbsp;Guillermo Garza,&nbsp;Hesam Abouali,&nbsp;Md Fahim Al Fattah,&nbsp;Ines Jaber,&nbsp;Dayan Ban,&nbsp;Marcelo Cypel,&nbsp;Mingyao Liu,&nbsp;Shaf Keshavjee,&nbsp;Andrew T. Sage,&nbsp;Mahla Poudineh","doi":"10.1002/advs.77123","DOIUrl":"10.1002/advs.77123","url":null,"abstract":"<p>Organ transplantation provides a life-saving intervention for patients with end-stage lung disease; however, access to this treatment remains limited by the shortage of donor organs. <i>Ex vivo</i> lung perfusion (EVLP) is a platform that enables surgeons to assess extended-criteria for donor lungs prior to transplantation and has safely expanded the donor pool. Yet current EVLP biochemical assessments rely on intermittent manual sampling and fail to capture dynamic metabolic changes. Here we present MetaboSense, a first-of-its-kind microfluidic platform for continuous, real-time, multiplexed monitoring of glucose and lactate—key metabolites that report on donor lung metabolism—during EVLP. The system integrates a bead-based, quantum dot-mediated aptamer assay with modular microfluidics for in-line biomarker measurement. MetaboSense achieves limits of detection of 0.74 mM (glucose) and 1.19 mM (lactate) with analytical precision (R² &gt; 0.97). Clinical validation across eleven EVLP cases demonstrates strong correlation with gold-standard arterial blood gas measurements. In-line deployment within an EVLP circuit during perfusion of porcine lungs confirms MetaboSense's ability to track metabolite fluctuations with 60-s temporal resolution. This platform eliminates labor-intensive sampling and provides unprecedented granularity in lung metabolomics during EVLP, representing an important step toward real-time EVLP analytics and improved organ selection and transplant outcomes.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the NR1D1–IGF2BP2–V-ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis-Induced Immunosuppression","authors":"Lang Chen,&nbsp;Wenyi Lin,&nbsp;Lang Jiang,&nbsp;Xuehui Gao,&nbsp;Chenyan Yu,&nbsp;Jili Han,&nbsp;Zhenping Liu,&nbsp;Xuefeng Li,&nbsp;Mei He,&nbsp;Chang Li,&nbsp;Qilan Li,&nbsp;Chaoying Song,&nbsp;Jiqian Xu,&nbsp;You Shang","doi":"10.1002/advs.77366","DOIUrl":"10.1002/advs.77366","url":null,"abstract":"<p>Patients with sepsis exhibit circadian disruption and persistent immunosuppression. However, the molecular mechanisms linking them remain unclear. Integration of multi-cohort transcriptomic and single-cell datasets shows that circadian gene dysregulation in patients with sepsis and septic mice correlates with disease severity and immunosuppressive states, with monocytes/macrophages emerging as a principal affected population. Sustained endotoxin stimulation elevates the core clock repressor NR1D1 in macrophages, which occupies the Igf2bp2 promoter and suppresses its transcription. Loss of IGF2BP2 destabilizes the V-ATPase subunit transcripts Atp6v1b2 and Atp6v0c through an m⁶A-dependent mechanism, disrupting phagolysosomal acidification rhythms and pathogen clearance. siRNA-mediated NR1D1 knockdown restores IGF2BP2 expression, circadian oscillations, and phagolysosomal function during the development of endotoxin tolerance. To achieve therapeutic delivery, we engineer hybrid membrane nanovesicles (siNR1D1@HM-LNP) that reverse circadian and immune dysregulation in septic mice, enhance bacterial clearance, and markedly improve survival. These findings establish an NR1D1-mediated circadian-immune coupling mechanism and provide a therapeutic strategy for targeting sepsis-induced immunosuppression.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion (Adv. Sci. 62/2026)","authors":"Sanjana Srikant,&nbsp;Pouyan Keshavarz Motamed,&nbsp;Thomas Borrillo,&nbsp;Lielle Ronen,&nbsp;Gabriel Siebiger,&nbsp;Guillermo Garza,&nbsp;Hesam Abouali,&nbsp;Md Fahim Al Fattah,&nbsp;Ines Jaber,&nbsp;Dayan Ban,&nbsp;Marcelo Cypel,&nbsp;Mingyao Liu,&nbsp;Shaf Keshavjee,&nbsp;Andrew T. Sage,&nbsp;Mahla Poudineh","doi":"10.1002/advs.78413","DOIUrl":"https://doi.org/10.1002/advs.78413","url":null,"abstract":"<p><b>MetaboSense</b></p><p>MetaboSense combines quantum dot-mediated aptamer sensing with modular microfluidics to continuously monitor glucose and lactate during ex vivo lung perfusion in human lungs being assessed for transplant suitability. Validated using clinical biospecimens, the platform captures metabolic fluctuations at 60-second resolution, offering a unique window into lung metabolism for advanced pre-transplant organ evaluation. More details can be found in the Research Article by Andrew T. Sage, Mahla Poudineh, and co-workers (DOI: 10.1002/advs.77123).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.78413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149369453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physics-Aware Machine-Learning-Driven Inverse Design of Broadband Ultra-Open Acoustic Metamaterials","authors":"Zhiwei Yang,&nbsp;Mengyu Li,&nbsp;Xiaohang Xie,&nbsp;Ao Chen,&nbsp;Thomas G. Bifano,&nbsp;Xin Zhang","doi":"10.1002/advs.76894","DOIUrl":"10.1002/advs.76894","url":null,"abstract":"<p>Ventilated acoustic silencers combining strong sound attenuation with high ventilation are pivotal for advanced noise control. However, balancing attenuation, bandwidth, openness, and thickness remains a high-dimensional challenge. Here, we present a physics-aware machine-learning-driven inverse design framework for broadband ultra-open acoustic silencers (UAS). Based on Green's function parameterization, the design space is physically decoupled into spectral and radial space, ensuring physical interpretability while reducing complexity. A two-stage coarse-to-fine surrogate model captures both broadband envelopes and sharp resonant features. Coupled with a population-based, hybrid-objective parallel (PHP) inverse strategy, our framework enables rapid exploration of non-convex landscapes, identifying hundreds of optimized candidates within seconds each. Crucially, this framework reveals the intrinsic relationship among thickness, ventilation, and spectral response, and uncovers hidden linear design rules that serve as geometric proxies for impedance-matching. We experimentally validate multiple architectures: UAS-2 represents the monolithic, single-mode design with high ventilation, whereas UAS-3 exploits multi-mode interference for improved spectral performance. To circumvent the trade-off ceiling of single-unit resonators, a parallel-composite architecture (UAS-4) is introduced to enhance performance. Results confirm a broadband bandwidth exceeding 830 Hz within 1000-2000 Hz, with ultra-thin profile (0.1–0.2λ, 4–8 cm) and 80% ventilation. This work establishes a data-driven paradigm for discovering design principles in functional metamaterials.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27-mediated ACLY Ubiquitination and Lipid Metabolism","authors":"Kang-Ping Xiong,&nbsp;Fei Liu,&nbsp;Wang Wang,&nbsp;Gang Wang,&nbsp;Kai-Yu Qian,&nbsp;Sheng Tu,&nbsp;Si-Ming Chen,&nbsp;Hui-Min Xu,&nbsp;Shan-Shan Zhang,&nbsp;Yong Li,&nbsp;Xing-Huan Wang,&nbsp;Hong Weng","doi":"10.1002/advs.77394","DOIUrl":"10.1002/advs.77394","url":null,"abstract":"<p>Prostate cancer (PCa) is a prevalent malignancy in men, and lipid metabolic reprogramming contributes to its progression and therapeutic resistance. However, the drivers of lipid metabolic dysregulation in PCa remain incompletely defined. Through transcriptomic sequencing of PCa patient tissues, we identified glutathione S-transferase mu 4 (GSTM4) as a novel regulator of lipid metabolism. GSTM4 was significantly downregulated in PCa tissues and negatively correlated with triglyceride content. Functionally, GSTM4 overexpression inhibited PCa cell proliferation and migration, thereby suppressing tumor development and bone metastasis. Mechanistically, GSTM4 acted independently of its classical detoxification activity by interacting with tripartite motif-containing 27 (TRIM27) and ATP citrate lyase (ACLY), a key enzyme in de novo lipid synthesis. GSTM4 promoted TRIM27-mediated ubiquitination and degradation of ACLY at lysine 554, reducing acetyl-CoA production and lipid accumulation. This inhibition of lipid synthesis suppressed PCa growth and metastasis in vitro and in subcutaneous, orthotopic, and bone metastasis models. Moreover, ETC-1002 (bempedoic acid), a clinically approved ACLY inhibitor, showed therapeutic potential against PCa. These findings reveal a non-canonical GSTM4-TRIM27-ACLY axis that regulates lipid metabolism and represents a promising therapeutic target for advanced PCa.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data","authors":"Maximilian Krebs,&nbsp;Herre Jelger Risselada","doi":"10.1002/advs.76899","DOIUrl":"10.1002/advs.76899","url":null,"abstract":"<p>Membrane-targeting peptide motifs recognize characteristic features of biological membrane targets through specific interactions with their lipid composition. To elucidate the complex relationship between binding sequences and lipid composition, an alternative computational framework to leverage limited sequence activity data by combining genetic algorithms with coarse-grained molecular dynamics simulations is proposed. As demonstrated through evolutionary optimization of model membranes containing mammalian lipid compositions, four true-positive and four false-positive antimicrobial peptide sequences contain sufficient signal to tune membrane properties that maximize the separation in insertion behavior between true positives (deep insertion) and false positives (shallow insertion) in coarse-grained molecular dynamics simulations. This yields a robust discriminative performance comparable to that of large data-driven classification methods on the balanced, small dataset tested. This finding reveals how subtle differences in lipid composition precisely control the selective binding of membrane-associated proteins, thereby regulating their trafficking, aggregation, and function within living cells. The used methodology reconstructs lipidomic profiles from limited sequence data, uniquely revealing targeting patterns for therapeutic peptides and the selectivity mechanisms of membrane-associated proteins.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmable Sequential 4D Actuation in Multistable Kirigami Metamaterials (Adv. Sci. 62/2026)","authors":"Eui-Hyun Kim,&nbsp;Minsung Kim,&nbsp;Hyunsik Yoon,&nbsp;Keun Park","doi":"10.1002/advs.78407","DOIUrl":"https://doi.org/10.1002/advs.78407","url":null,"abstract":"<p><b>Multistable 4D Kirigami Metamaterials</b></p><p>Inspired by the geometric motifs of traditional Korean <i>Dancheong</i> patterns, the cover image reimagines the decorated façade of a Korean temple using the multistable kirigami metamaterials developed in this work. Upon exposure to sunlight, the kirigami panels on the illuminated side undergo a thermally triggered 4D transformation, forming an outward-curved surface that visualizes the thermally programmed bridging mechanism demonstrated in the study. The image bridges traditional architectural aesthetics with programmable 4D-printed metamaterials, highlighting their potential for thermally responsive and adaptive structures. Further details can be found in article number ADVS77412 by Keun Park and co-workers (DOI: 10.1002/advs.77412).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.78407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149369501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}