Advanced Science最新文献

Preserving Motor Features by Alternative Re-Referencing to Remove Heart Artifact on the Stentrode. 保留运动特征的选择性再参照去除支架上的心脏伪影。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-04 DOI: 10.1002/advs.76647

Ariel K Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E Yoo, Raul G Nogueira, Jennifer L Collinger, Nicholas L Opie, Thomas J Oxley, David F Putrino, Douglas J Weber

{"title":"Preserving Motor Features by Alternative Re-Referencing to Remove Heart Artifact on the Stentrode.","authors":"Ariel K Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E Yoo, Raul G Nogueira, Jennifer L Collinger, Nicholas L Opie, Thomas J Oxley, David F Putrino, Douglas J Weber","doi":"10.1002/advs.76647","DOIUrl":"https://doi.org/10.1002/advs.76647","url":null,"abstract":"Vascular electrocorticography (vECoG) has shown great promise as a less-invasive alternative to penetrating electrode arrays for neural signal acquisition. This study investigates the signal quality of the Stentrode device, a leading vECoG platform, by contrasting artifact persistence with the preservation of low frequency motor cortical activity. Typical (re-)referencing schemes, including a monopolar stent-mounted reference, a common average reference, and a Laplacian reference, are shown to significantly reduce the presence of electrocardiogram (ECG) artifacts compared to a distal monopolar reference. However, resting state beta activity is also significantly diminished when employing these techniques. By using Band-Limited Independent Component Analysis (BL-ICA), a type of spatial filter that allows weighting of the noise on each electrode differently, ECG artifacts are easily separated from vECoG recordings. With this cleaning methodology, signals are reconstructed without the ECG component and the reduction in cross-channel correlation is evaluated, as well as the increase in relative entropy between rest and go distributions. To ensure that low-frequency motor features are preserved, beta bursts features are evaluated in both the source space and reconstructed signal space. BL-ICA is an effective technique to remove widespread ECG artifacts while maintaining typical motor-related features in beta band activity.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e76647"},"PeriodicalIF":14.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Imprinted Chirality in Nanomaterials: From Principles to Applications 纳米材料的光印迹手性：从原理到应用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-07-30 DOI: 10.1002/advs.202524331

Xinru Jin, Emiliano Cortés, Alexander O. Govorov, Tao Ding

{"title":"Light-Imprinted Chirality in Nanomaterials: From Principles to Applications","authors":"Xinru Jin, Emiliano Cortés, Alexander O. Govorov, Tao Ding","doi":"10.1002/advs.202524331","DOIUrl":"10.1002/advs.202524331","url":null,"abstract":"Light-induced chirality represents a transformative paradigm for fabricating chiral nanostructures, offering unique advantages over traditional approaches including chemical synthesis, self-assembly, and lithography. This review provides a comprehensive framework encompassing light-based strategies for imprinting and tuning chirality in nanomaterials, which includes laser direct writing, optical manipulation, CPL-induced symmetry breaking with the assistance of surface plasmons, optical vortex structuring, and momentum transfer. We critically compare different optical approaches, providing clear selection guidelines based on resolution, scalability, material compatibility, and equipment requirements. We also examine dynamic light-modulated chirality for switchable and reconfigurable structures, and highlight their emerging applications in biomedicine, sensing, polarization optics, and chiral displays. Finally, we conclude this review with current challenges and future directions. By establishing light-induced chirality as the most promising route for scalable chiral nanofabrication, this review guides researchers in harnessing light to create next-generation functional materials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Hermitian Stealthy Hyperuniformity (Adv. Sci. 49/2026) 非厄米隐形超均匀性（科学通报49/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77255

Gitae Lee, Seungmok Youn, Ikbeom Lee, Kunwoo Park, Duhwan Hwang, Seungkyun Park, Xianji Piao, Namkyoo Park, Sunkyu Yu

引用次数: 0

Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis. 白细胞介素-1α介导急性和慢性胰腺炎的胰腺成纤维细胞活化，调节免疫细胞募集和纤维化。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77558

Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler

{"title":"Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis.","authors":"Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler","doi":"10.1002/advs.77558","DOIUrl":"https://doi.org/10.1002/advs.77558","url":null,"abstract":"Pancreatitis is a life-threatening inflammatory disease of the pancreas. The cytokine interleukin-1α has been demonstrated to act as an alarmin released by necrotic cells. In the present study, we investigated the influence of IL-1α on the immune response during acute and chronic pancreatitis. Following tissue injury, pancreatic acinar cells released IL-1α, which activates tissue-resident fibroblasts to differentiate toward a pro-inflammatory phenotype. By secreting chemokines and cytokines such as CXCL5, CCL2, and IL-6, these fibroblasts recruit immune cells to the pancreas. The absence of IL-1α reduces disease severity in acute pancreatitis and chemokine release. Furthermore, IL-1α primes fibroblasts to enhance the production of extracellular matrix-components by the up-regulation of pro-fibrotic receptors such as Il4ra, Il13ra1, and Tgfbr3. Therefore, the deletion of IL-1α significantly reduced the development of tissue fibrosis. A therapeutic blockade of the IL1R1-signaling by i.p. administration of the IL-1-receptor antagonist Anakinra showed the same effect; the severity of acute pancreatitis and fibrogenesis during chronic pancreatitis were reduced. In conclusion, the crosstalk between necrotic acinar cells and fibroblasts mediated by IL-1α plays a crucial role in acute inflammation of the pancreas and fibrogenic signaling. Blockade of IL1R1-signaling by Anakinra is therefore a promising therapeutic intervention for both acute and chronic pancreatitis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77558"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis. 胸腺素α -1通过参与食欲素受体HCRTR1抑制神经元坏死提供直接的神经保护。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.202522372

Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu

{"title":"Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis.","authors":"Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu","doi":"10.1002/advs.202522372","DOIUrl":"https://doi.org/10.1002/advs.202522372","url":null,"abstract":"Communication between the immune system and the brain is critical for neuronal health, yet the molecular signals that mediate this crosstalk are not fully understood. Here, we uncover an unexpected and direct neuroprotective axis linking the thymus to the central nervous system (CNS). We show that the thymus-derived peptide Thymosin alpha-1 (Tα1) functions as a non-canonical ligand for the Hypocretin (Orexin) Receptor 1 (HCRTR1), a classical neuropeptide receptor on neurons. This engagement shields neurons from cell death by suppressing the activity of Receptor-Interacting Protein Kinase 3 (RIPK3), a central executioner of necroptosis. The physiological relevance of this pathway is highlighted in ischemic stroke, where we found that circulating Tα1 levels were significantly reduced in patients and mice, strongly correlating with disease severity. Genetic deletion of the Tα1-encoding gene Ptma exacerbated stroke injury, whereas therapeutic administration of Tα1 conferred robust neuroprotection and improved functional recovery. Our findings identify a novel thymus-brain signaling pathway, revealing a new neuroprotective function for an immune peptide and an unexpected role for a canonical neuronal receptor. This work establishes Tα1 as a promising dual-action therapeutic candidate, capable of both direct neuronal protection and systemic immunomodulation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e22372"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Direct Magnetoelectric Effect in Nanocomposite CoFe₂O₄:PVDF-TrFE Thin Films. 纳米复合CoFe2O4:PVDF-TrFE薄膜的巨直接磁电效应

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77469

Muireann de H-Óra, Lynette Keeney, Rui Miguel Gonçalves Carvalho, Aliona Nicolenco, Tuhin Maity, Jordi Sort, Luís Amorim, Pedro Martins, Judith MacManus-Driscoll

{"title":"Giant Direct Magnetoelectric Effect in Nanocomposite CoFe2O4:PVDF-TrFE Thin Films.","authors":"Muireann de H-Óra, Lynette Keeney, Rui Miguel Gonçalves Carvalho, Aliona Nicolenco, Tuhin Maity, Jordi Sort, Luís Amorim, Pedro Martins, Judith MacManus-Driscoll","doi":"10.1002/advs.77469","DOIUrl":"https://doi.org/10.1002/advs.77469","url":null,"abstract":"Polymer-based magnetoelectric (ME) materials are at the forefront of modern materials science. They have immense potential in a wide range of technological applications, including sensors, energy harvesters, and advanced memory and logic devices. Thus, the combination of magnetostrictive (MS) nanomaterials with lightweight flexible piezoelectric (PE) polymers enables the development of multifunctional systems suitable for versatile applications in the mechanical, electrical, and magnetic domains. Here, a novel three-step fabrication process was employed to create a uniquely structured MS/PE nanocomposite. First, a vertically aligned nanocomposite (VAN) thin film of MS CoFe2O4 (CFO) nanopillars, self-assembled in a benign MgO matrix phase, was grown. Then, wet chemical etching of the benign MgO phase was undertaken. Finally, the CFO nanopillars were coated with a ferroelectric (FE) polymer. The high interfacial area, highly crystalline nanocomposite system enabled efficient strain-mediated coupling between the magnetic and electric order parameters. Thus, a significantly enhanced magnetoelectric coefficient ( <math><msubsup><mi>α</mi> <mn>33</mn> <mrow><mi>D</mi> <mi>M</mi> <mi>E</mi></mrow> </msubsup> </math> ) of 10 ± 1 V cm- 1Oe- 1 was achieved at room temperature, nearly two orders of magnitude higher than similar composite thin film systems previously reported. Our method offers a simple, versatile, and scalable approach to fabricating very high-performance ME thin film devices.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77469"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrically Tunable Graphene-Metal Hybrid Metasurfaces for High-Efficiency, Broadband Mid-Infrared Transmission Modulation. 用于高效率宽带中红外传输调制的电可调谐石墨烯-金属混合超表面。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77550

Heonhak Ha, Jinseok Kong, Junhyung Kim, Jiwon Kang, Min Seok Jang

{"title":"Electrically Tunable Graphene-Metal Hybrid Metasurfaces for High-Efficiency, Broadband Mid-Infrared Transmission Modulation.","authors":"Heonhak Ha, Jinseok Kong, Junhyung Kim, Jiwon Kang, Min Seok Jang","doi":"10.1002/advs.77550","DOIUrl":"https://doi.org/10.1002/advs.77550","url":null,"abstract":"Transmissive active metasurfaces are essential for ultra-compact on-chip optical systems and are widely used in sensing, imaging, and spectroscopy. However, these devices generally suffer from lower efficiency and greater design complexity compared to their reflective counterparts. In this work, an electrically tunable transmission filter based on single-layer graphene integrated with a capacitive gold grating on a mid-IR transparent CaF2 substrate is demonstrated. By employing an ionic gel gating scheme to induce a high Fermi level in graphene, the device achieves a high transmission modulation efficiency of 73.3% for TM-polarized light, along with a broad operational bandwidth of 742 cm-1. Furthermore, by modifying the device structure, an ultrawide operational bandwidth of 1949 cm-1 can be achieved at the expense of reducing the modulation efficiency to 44%, outperforming previously reported electrically tunable mid-IR transmissive metasurfaces. Equivalent circuit model analysis reveals that this extraordinary modulation and bandwidth arise from the dynamic formation of a parallel LC resonance between the tunable inductive response of highly doped graphene and the metal grating's capacitive response. Furthermore, leveraging the spectral diversity generated by this Fermi-level modulation, the platform is computationally demonstrated to operate as a single-pixel mid-IR spectrometer. These results provide a platform for ultra-compact mid-IR applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77550"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Low-Melting-Point and High-Conductivity Molten Salts via High-Entropy Strategy with Demonstration in Thermal Batteries. 利用高熵策略解锁低熔点高导电性熔盐及其在热电池中的应用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.76847

Binchao Shi, Ting Sun, Fushan Yu, Yi Zhang, Gaowu Wang, Ting Quan, Yan-Li Zhu

引用次数: 0

6.1% Volumetric Negative Thermal Expansion Induced by the Reversible Reconstructive Phase Transition in Pb-Free Bi_1- _xLn_xCoO₃ (Ln: Lanthanoid). 无铅Bi1- xLnxCoO3 （Ln: Lanthanoid）可逆重构相变诱导的6.1%体积负热膨胀

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77022

Yuki Sakai, Kazuki Takahashi, Shogo Wakazaki, Takumi Nishikubo, Jun Miyake, Takehiro Koike, Teppei Nagase, Takafumi Yamamoto, Kano Hatayama, Masaichiro Mizumaki, Masaki Azuma

{"title":"6.1% Volumetric Negative Thermal Expansion Induced by the Reversible Reconstructive Phase Transition in Pb-Free Bi1- xLnxCoO3 (Ln: Lanthanoid).","authors":"Yuki Sakai, Kazuki Takahashi, Shogo Wakazaki, Takumi Nishikubo, Jun Miyake, Takehiro Koike, Teppei Nagase, Takafumi Yamamoto, Kano Hatayama, Masaichiro Mizumaki, Masaki Azuma","doi":"10.1002/advs.77022","DOIUrl":"10.1002/advs.77022","url":null,"abstract":"Negative thermal expansion (NTE) materials, which can compensate for the thermal expansion of structural materials, have attracted much attention in the field of nanoscale electronics and optical devices requiring precise positioning. The present paper demonstrates a reversible colossal NTE in the perovskite-type oxide lanthanoid-substituted BiCoO3. The 6.1% volume shrinkage in Bi0.82Nd0.18CoO3 is the largest ever observed in Pb-free NTE materials. Synchrotron X-ray diffraction and Co L-edge soft X-ray absorption spectroscopy measurements and machine learning force field molecular dynamics simulations confirm that the origin of the NTE is the coordination change from the CoO5 pyramid with high-spin Co3+ to the CoO6 octahedron with the LaCoO3-type Co3+ spin state (intermediate-spin state or mixture of high-spin and low-spin states) due to melting of the dxy orbital ordering in the d6 electron configuration. The NTE properties as functions of ionic radius and concentration of substituting Ln ions are well explained by the nucleation mechanism of the reconstructive martensitic phase transition. The present results offer a new strategy for developing large-NTE materials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77022"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation” 更正“POU2F1通过减弱PPP1R11乳酸化介导的MDR2降解促进结直肠癌细胞的化疗耐药”。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-07-30 DOI: 10.1002/advs.76815

引用次数: 0