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Self-Adaptive Quantum Kernel Principal Component Analysis for Compact Readout of Chemiresistive Sensor Arrays (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570102
Zeheng Wang, Timothy van der Laan, Muhammad Usman
{"title":"Self-Adaptive Quantum Kernel Principal Component Analysis for Compact Readout of Chemiresistive Sensor Arrays (Adv. Sci. 15/2025)","authors":"Zeheng Wang,&nbsp;Timothy van der Laan,&nbsp;Muhammad Usman","doi":"10.1002/advs.202570102","DOIUrl":"https://doi.org/10.1002/advs.202570102","url":null,"abstract":"<p><b>Quantum Machine Learning</b></p><p>In article number 2411573, Zeheng Wang, Timothy van der Laan, and Muhammad Usman introduce a quantum algorithm-driven framework to compress chemiresistive sensor data. By employing a self-adaptive quantum kernel (SAQK), classical data are mapped into a quantum state space, where quantum principal component analysis (qPCA) is used to achieve significant dimensionality reduction. This innovative method not only minimizes information loss but also improves the subsequent AI-driven readout accuracy. The work highlights the synergy of quantum algorithms and AI, paving the way for efficient IoT data handling on noisy intermediate-scale quantum (NISQ) devices.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaseous Synergistic Self-Assembly and Arraying to Develop Bio-Organic Photocapacitors for Neural Photostimulation (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570103
Xinyuan Fan, Yiming Tang, Jiahao Zhang, Kang Ma, Zhengyu Xu, Yuying Liu, Bin Xue, Yi Cao, Deqing Mei, Wei Wang, Guanghong Wei, Kai Tao
{"title":"Gaseous Synergistic Self-Assembly and Arraying to Develop Bio-Organic Photocapacitors for Neural Photostimulation (Adv. Sci. 15/2025)","authors":"Xinyuan Fan,&nbsp;Yiming Tang,&nbsp;Jiahao Zhang,&nbsp;Kang Ma,&nbsp;Zhengyu Xu,&nbsp;Yuying Liu,&nbsp;Bin Xue,&nbsp;Yi Cao,&nbsp;Deqing Mei,&nbsp;Wei Wang,&nbsp;Guanghong Wei,&nbsp;Kai Tao","doi":"10.1002/advs.202570103","DOIUrl":"https://doi.org/10.1002/advs.202570103","url":null,"abstract":"<p><b>Neural Photostimulation</b></p><p>In article number 2410471, Kai Tao, Guanghong Wei, and co-workers develop a gaseous organization strategy using the physical vapor deposition technology to achieve synergistic self-assembly and arraying of bio-organic architectures. This enables Fmoc-FF molecules to self-assemble into unpredicted microspheres, offering programmable optoelectronic properties for bio-machine interfaces. The cover artwork illustrates a bio-photocapacitor engineered with these spherical arrays, designed for noninvasive and non-genetic neural photostimulation, showcasing a promising potential in biomedical engineering and neural interfacing applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570108
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong
{"title":"The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ (Adv. Sci. 15/2025)","authors":"Xiaofang Luo,&nbsp;Biao Huang,&nbsp;Ping Xu,&nbsp;Hao Wang,&nbsp;Baozhen Zhang,&nbsp;Li Lin,&nbsp;Jiujiang Liao,&nbsp;Mingyu Hu,&nbsp;Xiyao Liu,&nbsp;Jiayu Huang,&nbsp;Yong Fu,&nbsp;Mark D. Kilby,&nbsp;Rodney E. Kellems,&nbsp;Xiujun Fan,&nbsp;Yang Xia,&nbsp;Philip N. Baker,&nbsp;Hongbo Qi,&nbsp;Chao Tong","doi":"10.1002/advs.202570108","DOIUrl":"https://doi.org/10.1002/advs.202570108","url":null,"abstract":"<p><b>Fetal Growth Restriction</b></p><p>Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus participate in the transcriptional regulation of downstream genes, which is not identical to that of endogenous PPARγ in preadipocytes. Compromised PPARγ in the placenta causes deficient adipogenesis in the fetus and intruterine growth restriction but can be rescued by placenta-targeted activation of PPARγ. More details can be found in article number 2404983 by Hongbo Qi, Chao Tong, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570104
Yuhang Guo, Shihua Luo, Sinian Liu, Chao Yang, Weifeng Lv, Yuxin Liang, Tingting Ji, Wenbin Li, Chunchen Liu, Xin Li, Lei Zheng, Ye Zhang
{"title":"Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection (Adv. Sci. 15/2025)","authors":"Yuhang Guo,&nbsp;Shihua Luo,&nbsp;Sinian Liu,&nbsp;Chao Yang,&nbsp;Weifeng Lv,&nbsp;Yuxin Liang,&nbsp;Tingting Ji,&nbsp;Wenbin Li,&nbsp;Chunchen Liu,&nbsp;Xin Li,&nbsp;Lei Zheng,&nbsp;Ye Zhang","doi":"10.1002/advs.202570104","DOIUrl":"https://doi.org/10.1002/advs.202570104","url":null,"abstract":"<p><b>Accurate Gastric Cancer Detection</b></p><p>In this study a bimodal EV-circRNA analyzer (BEISA) for detecting circular RNA in gastric cancerderived extracellular vesicles (EVs) is developed. BEISA employs RF-HCR to generate dual fluorescent and electrochemical signals in situ. Combined with machine learning, it can effectively differentiate early gastric cancer patients from healthy donors. More details can be found in article number 2409202 by Lei Zheng, Ye Zhang, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570110
Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan
{"title":"LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease (Adv. Sci. 15/2025)","authors":"Fuji Yang,&nbsp;Yifei Chen,&nbsp;Guojun Zheng,&nbsp;Kefeng Gu,&nbsp;Lin Fan,&nbsp;Tingfen Li,&nbsp;Ling Zhu,&nbsp;Yongmin Yan","doi":"10.1002/advs.202570110","DOIUrl":"https://doi.org/10.1002/advs.202570110","url":null,"abstract":"<p><b>Dysfunction-Associated Steatotic Liver Disease</b></p><p>High-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis. LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH. More details can be found in article number 2415941 by Yongmin Yan and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570107
Ninan Zhang, Ruifan Lin, Wenya Gao, Honglin Xu, Yuejia Li, Xiahe Huang, Yingchun Wang, Xianghong Jing, Wenxiang Meng, Qi Xie
{"title":"Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response (Adv. Sci. 15/2025)","authors":"Ninan Zhang,&nbsp;Ruifan Lin,&nbsp;Wenya Gao,&nbsp;Honglin Xu,&nbsp;Yuejia Li,&nbsp;Xiahe Huang,&nbsp;Yingchun Wang,&nbsp;Xianghong Jing,&nbsp;Wenxiang Meng,&nbsp;Qi Xie","doi":"10.1002/advs.202570107","DOIUrl":"https://doi.org/10.1002/advs.202570107","url":null,"abstract":"<p><b><i>Curcuma aromatica</i></b></p><p>This frontispiece features <i>Curcuma aromatica</i> (Yu Jin), a traditional Chinese medicine used for over 2000 years in China to treat epilepsy and other diseases. In article number 2405263, Wenxiang Meng, Qi Xie, and co-workers reveal its molecular mechanism in regulating neuroinflammation and m6A RNA modification. Image drawn by artist Ding Han.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of Graphene Polyhedra: Unveiling New Structures, Forms, and Properties (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570106
Joong Yeon Lim, Seonghwan Kim, Muhammad Toyabur Rahman, Young-Seong Kim
{"title":"Fabrication of Graphene Polyhedra: Unveiling New Structures, Forms, and Properties (Adv. Sci. 15/2025)","authors":"Joong Yeon Lim,&nbsp;Seonghwan Kim,&nbsp;Muhammad Toyabur Rahman,&nbsp;Young-Seong Kim","doi":"10.1002/advs.202570106","DOIUrl":"https://doi.org/10.1002/advs.202570106","url":null,"abstract":"<p><b>Fabrication of Graphene Polyhedra</b></p><p>The metal-doped nanoporous carbon material exhibits magnetoelectric coupling properties, with spin polarization increasing under a strong electric field. Notably, in magnetic force microscopy, spin polarization varies depending on the approach direction of the tip. More details can be found in article number 2414108 by Joong Yeon Lim, Young-Seong Kim, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570105
{"title":"Issue Information: (Adv. Sci. 15/2025)","authors":"","doi":"10.1002/advs.202570105","DOIUrl":"https://doi.org/10.1002/advs.202570105","url":null,"abstract":"","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Microalgae-Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570101
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang
{"title":"Oral Microalgae-Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma (Adv. Sci. 15/2025)","authors":"Cheng Zeng,&nbsp;Shiyuan Hua,&nbsp;Jiayu Zhou,&nbsp;Tangye Zeng,&nbsp;Jianke Chen,&nbsp;Lijian Su,&nbsp;Angfeng Jiang,&nbsp;Min Zhou,&nbsp;Zhe Tang","doi":"10.1002/advs.202570101","DOIUrl":"https://doi.org/10.1002/advs.202570101","url":null,"abstract":"<p><b>Irreversible Electroporation Immunotherapy</b></p><p>In article number 2409381, Min Zhou, Zhe Tang, and co-workers present a microalgae-based drug delivery system, showcasing the oral administration of engineered microalgae carrying immunomodulators for liver cancer treatment. In synergy with irreversible electroporation technology, it activates systemic anti-tumor immunity. Through innovative collaboration between biomaterials and physiotherapy, it breaks through the limitations of traditional treatments and provides a new paradigm for precise immunotherapy of liver cancer.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis (Adv. Sci. 15/2025)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2025-04-17 DOI: 10.1002/advs.202570109
Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning
{"title":"Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis (Adv. Sci. 15/2025)","authors":"Yin Zhu,&nbsp;Yurui Liu,&nbsp;Xiangtao Wang,&nbsp;Zhifeng Chen,&nbsp;Baojian Chen,&nbsp;Bingxin Hu,&nbsp;Tiane Tang,&nbsp;Haoran Cheng,&nbsp;Xinglong Liu,&nbsp;Yunshan Ning","doi":"10.1002/advs.202570109","DOIUrl":"https://doi.org/10.1002/advs.202570109","url":null,"abstract":"<p><b>Endoplasmic Reticulum Stress Response</b></p><p>Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function. These actions provoke endoplasmic reticulum (ER) stress and activate the unfolded protein response within tumor cells. This, in turn triggers the UBA6-UBE2ZFBXW7 ubiquitin cascade, enhancing ER stress-associated ubiquitylation and degradation of EZH2 and MYC, ultimately resulting in tumor growth arrest. More details can be found in article number 2413120 by Yunshan Ning and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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