Advanced Science最新文献

Artificial Intelligence-Assisted Urine Cytology for Noninvasive Detection of Muscle-Invasive Urothelial Carcinoma: A Multi-Center Diagnostic Study with Prospective Validation. 人工智能辅助尿细胞学无创检测肌肉侵袭性尿路上皮癌：一项前瞻性多中心诊断研究。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202508977

Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu

{"title":"Artificial Intelligence-Assisted Urine Cytology for Noninvasive Detection of Muscle-Invasive Urothelial Carcinoma: A Multi-Center Diagnostic Study with Prospective Validation.","authors":"Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu","doi":"10.1002/advs.202508977","DOIUrl":"https://doi.org/10.1002/advs.202508977","url":null,"abstract":"Accurate preoperative diagnosis of muscle invasion (MI) is critical for urothelial carcinoma (UC) management. The aim is to evaluate whether artificial intelligence (AI) model based on urine cytology can accurately detect MIUC and compare its performance with radiologist assessments. UC patients underwent liquid-based urine cytology from four centers are included for model development/validation. Performance of the precision urine cytology AI solution for MI (PUCAS-M) is validated across multicenter cohorts and compared to radiologists' assessments (including CT/MR, MR accounted for 40.7%). Clinical utility is assessed for initial diagnosis, recurrence detection, and neoadjuvant therapy. PUCAS-M achieves an area under the receiver operation curve (AUROC) of 0.857 (95% CI: 0.820-0.895) in the whole validation cohort, which is significantly higher (P-value = 0.005) than radiologists (0.773, 95% CI: 0.727-0.818). The integration of radiologists' diagnosis and PUCAS-M (mPUCAS-M) significantly increases the sensitivity of radiologists from 63.9% to 83.3% in bladder cancer and from 76.9% to 90.3% in upper-tract UC. Lastly, in the neoadjuvant therapy subgroups, mPUCAS-M maintains an improved AUROC (ranging from 0.857-0.865), whereas radiologist assessments' performance decline. PUCAS-M provides accurate, non-invasive MI detection method, particularly valuable for equivocal imaging. Integration with clinical data enhances diagnostic precision, offering a scalable solution for UC management.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08977"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular Polarimetric Imaging with a Metamaterial Integrated Long-Wavelength Infrared Focal Plane Array. 基于超材料集成长波红外焦平面阵列的圆偏振成像。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202509292

Tianyun Zhu, Ling Wang, Wenji Jing, Jie Deng, Jiexian Ye, Yujie Zhang, Zeshi Chu, Jing Zhou, Xiaoshuang Chen, Xiangyang Li, Wei Lu, Xuechu Shen

{"title":"Circular Polarimetric Imaging with a Metamaterial Integrated Long-Wavelength Infrared Focal Plane Array.","authors":"Tianyun Zhu, Ling Wang, Wenji Jing, Jie Deng, Jiexian Ye, Yujie Zhang, Zeshi Chu, Jing Zhou, Xiaoshuang Chen, Xiangyang Li, Wei Lu, Xuechu Shen","doi":"10.1002/advs.202509292","DOIUrl":"https://doi.org/10.1002/advs.202509292","url":null,"abstract":"Long-wavelength infrared (LWIR) circular polarimetric imaging plays an important role in many areas. The immediacy of polarimetric imaging and the miniaturization of devices drive considerable efforts to division-of-focal-plane-array (DoFPA) circular polarimeters. However, the realization of such detectors is hampered by low polarization discrimination, reduced absorption in the detection material, and fabrication complexity. The situation becomes more serious in the LWIR range since the pixel size is only a few wavelengths of the incident light. Here, a quantum well infrared photodetector based LWIR DoFPA circular polarimeter featuring a 320 × 256 pixel array integrated with a chiral meta-mirror array is established. The spectral range of this detector is from 10 to 11 µm. Taking advantage of the dual polarization selection, a CPER of 23.3 is achieved for the pixels integrated with the same chiral meta-mirror structure, and a CPER of 5.67 for the pixels integrated with left- and right-handed chiral meta-mirror structures in a checkerboard pattern. The peak responsivity is improved by a factor of 9.13 compared to a standard reference device. With the LWIR DoFPA circular polarimeter, Stokes parameter S3 imaging is achieved with a noise equivalent S3 difference of 1.16×10-4, and demonstrate background suppression and target highlighting.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09292"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Role of MDK-SDC4 Interaction in Pancreatic Cancer-Associated New-Onset Diabetes by Single-Cell Transcriptomic Analysis. 通过单细胞转录组学分析揭示MDK-SDC4相互作用在胰腺癌相关新发糖尿病中的作用

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202409987

Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu

{"title":"Unraveling the Role of MDK-SDC4 Interaction in Pancreatic Cancer-Associated New-Onset Diabetes by Single-Cell Transcriptomic Analysis.","authors":"Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu","doi":"10.1002/advs.202409987","DOIUrl":"https://doi.org/10.1002/advs.202409987","url":null,"abstract":"Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer-associated new-onset diabetes (PCAND) and new-onset type 2 diabetes mellitus (T2DM) holds promise for enabling an earlier diagnosis of pancreatic cancer. Nevertheless, the absence of effective biomarkers for distinguishing PCAND from the more prevalent new-onset T2DM persists, primarily because of the elusive pathogenesis of PCAND. In this study, the intricate intercellular communication is comprehensively elucidated through single-cell RNA sequencing. The findings identified Midkine (MDK) as a potential mediator of the interaction between tumor and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin production and secretion. Notably, the plasma levels of MDK are higher in patients with PCAND than in those with T2DM. In conclusion, MDK has emerged as a pivotal driver of PCAND pathogenesis and may function as a blood-based biomarker for discriminating between PCAND and T2DM in populations with new-onset diabetes, thereby facilitating the advancement of early detection strategies for pancreatic cancer.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09987"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Assisted Synthesis of Cu/Co-Based Nanoheterostructures for High-Efficiency Alcohol Oxidation. 微波辅助合成Cu/ co基纳米异质结构用于高效醇氧化。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505581

Xuesong Zhang, Jaume Gázquez, Arturo Pajares, Dino Tonti, Pablo Guardia

{"title":"Microwave-Assisted Synthesis of Cu/Co-Based Nanoheterostructures for High-Efficiency Alcohol Oxidation.","authors":"Xuesong Zhang, Jaume Gázquez, Arturo Pajares, Dino Tonti, Pablo Guardia","doi":"10.1002/advs.202505581","DOIUrl":"https://doi.org/10.1002/advs.202505581","url":null,"abstract":"Hybrid water splitting, using methanol or ethanol oxidation reactions (MOR and EOR) at the counter electrode during electrochemical hydrogen generation, offers an efficient alternative to the sluggish oxygen evolution reaction (OER). This study reports Cu/Co-based core-shell nanocrystals (NCs) showing excellent performance for both MOR and EOR. The structure, composition and size of the NCs can be controlled by adjusting the synthesis parameters in a one-pot microwave-assisted process. The electrocatalytic performance of the NCs shows lower potentials for both MOR and EOR compared to the OER. They consist of a copper-rich metallic core initially encapsulated by a shell composed of cobalt oxide and cobalt carbide. This nanoheterostructure evolves to a copper oxide core surrounded by an oxide shell consisting of small cobalt- and copper-oxide nanodomains upon chronopotentiometry experiments. The excellent performance in both MOR and EOR is attributed to the oxidation of the NCs and a concomitant diffusion process that forms small oxide clusters. The final structure provided NCs with high mass activities for both alcohol oxidation reactions, producing formic and acetic acid as products (for MOR and EOR, respectively). Finally, the NCs are tested for hybrid water electrolysis, demonstrating high hydrogen production along with high stability.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05581"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprinted Organoids: An Innovative Engine in Biomedicine. 生物打印类器官：生物医学的创新引擎。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202507317

Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan

{"title":"Bioprinted Organoids: An Innovative Engine in Biomedicine.","authors":"Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan","doi":"10.1002/advs.202507317","DOIUrl":"https://doi.org/10.1002/advs.202507317","url":null,"abstract":"Bioprinted organoids integrate bioprinting technology with organoid research, enabling the simultaneous reconstruction of human tissue morphology and physiological function in vitro. This approach offers distinct advantages in organoid fabrication, particularly in terms of structural precision, tissue mimicry, and functional fidelity. By leveraging the complementary strengths of both technologies, bioprinted organoids allow for the fabrication of personalized, architecturally engineered models that more accurately replicate organogenesis, physiological processes, and disease progression. Herein, this review outlines the key advantages of bioprinted organoids, with a focus on their ability to precisely control morphology, dimensions, and spatial organization. Bioprinted organoids are further categorized into three types based on their cellular origins and summarize recent progress in their application for human tissue modeling. Finally, ongoing challenges and future possibilities are sketched out, offering insights for potential innovation and research directions in the field. Bioprinted organoids not only propel the advancement of organoid research but also drive the evolution of bioprinting technologies. This integrated approach represents a powerful synergy between biomanufacturing and clinical medicine to pave the way for a new era in biomedical science and personalized healthcare.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07317"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca²⁺ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. 溶酶体逆行运输的激活触发溶酶体-内质网MCSs的TPC1-IP3R1 Ca2+串扰，导致内质网钙的致命消耗。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202415313

Meng-Yuan Zhu, Yong-Jian Guo, Yu-Qi Zhu, Hong-Zheng Wang, Hai-di Wang, Hong-Yu Chen, Yue-Xin Jiang, Hui Li, Hui Hui

{"title":"Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.","authors":"Meng-Yuan Zhu, Yong-Jian Guo, Yu-Qi Zhu, Hong-Zheng Wang, Hai-di Wang, Hong-Yu Chen, Yue-Xin Jiang, Hui Li, Hui Hui","doi":"10.1002/advs.202415313","DOIUrl":"https://doi.org/10.1002/advs.202415313","url":null,"abstract":"Inter-organellar signaling linkages in oncology are increasingly elucidated. However, the impact of lysosome-endoplasmic reticulum (ER) interaction on tumor cell fate remains relatively unexplored. A novel interaction between lysosomes and the ER, mediated by the flavonoid LW-213 through targeting LIMP2 (lysosomal integral membrane protein type 2)to activate a lysosomal repair pathway, is identified in acute myeloid leukemia (AML). This leads to activated RAB7A activity, enhancing lysosomal retrograde transport to the perinuclear region and increasing contact at lysosome-ER membrane contact sites (MCSs). Close proximity of TPC1 to IP3R1 at these sites generates a concentrated calcium microdomain, triggering Ca2+-induced Ca2+ release, which causes cytoplasmic calcium turbulence and two distinct calcium tides. This excessive calcium efflux depletes ER calcium stores, triggering lethal ER stress-induced apoptosis. Interestingly, altering TPC1 expression levels in HeLa cells affected these calcium dynamics, replicating AML-specific mechanisms when overexpressed. Subsequent studies using BALB/c xenograft models with wild-type and LIMP2-knockout THP1 cells, along with ICR mice toxicity models, confirmed LW-213's significant tumor growth inhibition with minimal toxicity. These findings underscore the potential of targeting lysosomal-ER calcium crosstalk as an innovative approach to cancer treatment, highlighting the therapeutic promise of LW-213 in managing tumor cell fate through modulating organellar interactions.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15313"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast Li₂O₂ Electrochemistry Enabled by Co-N_x/Co (111) with Optimized Intermediate Adsorption. 优化中间吸附的Co- nx /Co（111）实现Li₂O₂快速电化学

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202510256

Lili Liu, Chen Wang, Luxin Zhao, Yayun Xiao, Weiwei Fang, Lanling Zhao, Faxing Wang, Yuping Wu

{"title":"Fast Li₂O₂ Electrochemistry Enabled by Co-Nx/Co (111) with Optimized Intermediate Adsorption.","authors":"Lili Liu, Chen Wang, Luxin Zhao, Yayun Xiao, Weiwei Fang, Lanling Zhao, Faxing Wang, Yuping Wu","doi":"10.1002/advs.202510256","DOIUrl":"https://doi.org/10.1002/advs.202510256","url":null,"abstract":"The practical development of Li-O2 batteries (LOBs) urgently needs to explore robust cathode catalysts to boost the sluggish Li2O2 reaction kinetics and parasitic reactions despite their theoretically high specific energy. Profound understanding of the cathode properties and the battery performance is rather critical in developing rational-designed electrocatalysts. In this study, a Co-Nx/Co (111) decorated N-doped hierarchical carbon framework (Co-Nx/Co@NHCF) is proposed as an efficient cathode in LOBs. Spectroscopic analysis coupled with experimental results suggests that the Co-Nx/Co (111) catalytic center can significantly reduce the battery overpotential, and meanwhile, the hierarchical carbon framework ensures rapid mass transportation and provides sufficient space to accommodate Li2O2 deposition. Density functional theory calculations reveal that the incorporated Co (111) facet can effectively regulate the electronic distribution of N-carbon, optimize the adsorption of desirable intermediates, and eventually facilitate oxygen reduction reaction/oxygen evolution reaction kinetics. As expected, the Co-Nx/Co@NHCF catalyzed LOBs deliver a high discharge/charge capacity of 6.15/ 6.22 mAh cm-2 with a columbic efficiency of 98.9%, along with a high rate cycling of 700 h at 0.3 mA cm-2. This work provides valuable instruction for the rational design of efficient catalysts for high-performance LOBs via optimization of the crystal structure and the adsorption of intermediates.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e10256"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia. 血浆代谢谱与机器学习揭示病理性近视的独特诊断和生物学特征。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505861

Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu

{"title":"Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia.","authors":"Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu","doi":"10.1002/advs.202505861","DOIUrl":"https://doi.org/10.1002/advs.202505861","url":null,"abstract":"Pathologic myopia (PM), characterized by serious myopic macular degeneration (MMD), is a detrimental subtype of high myopia (HM) and has become one of the leading causes of blindness worldwide. In this concern, precise and high-throughput molecular diagnosis and further pathologic insights are urgently needed. Here, through the combined strategy of nanoparticle-enhanced laser desorption/ionization mass spectrometry-based rapid metabolic analysis (<30 s) and machine learning, a precise molecular diagnostic approach of PM (HM with MMD grade ≥ 2) is proposed, which achieves areas under the curve of 0.874 and 0.889 for diagnosing PM and early-stage PM, respectively. Further, the biomarkers indicate the PM-associated systemic metabolic reprogramming of amino acid and lipid metabolism, which may mediate dysfunctional oxidative stress, inflammation, hormone/neurotransmitter systems, and energy metabolism. Notably, MMD grade 4, featuring characteristic macula atrophy, exhibits specificity in this metabolic reprogramming. Of these biomarkers, azelaic acid shows a significant protective effect in the ARPE-19 cells under abnormal oxidative stress, which may be involved in PM development as a key antioxidative active metabolite. This work will contribute to PM molecular diagnosis and pathology exploration.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05861"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Oxygen Vacancies in LiCoO₂ on the Electrochemical Performance of Garnet-Based All-Solid-State Li-Metal Batteries. LiCoO2中氧空位对石榴石基全固态锂金属电池电化学性能的影响

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202508750

Zhizhen Qin, Jehad Ahmed, Sebastian Speer, Dmitri L Danilov, Anna Windmüller, Shicheng Yu, Chih-Long Tsai, Hermann Tempel, Josef Granwehr, Wen-Wei Wu, Jeng-Kuei Chang, Rüdiger-A Eichel, Peter H L Notten

{"title":"Impact of Oxygen Vacancies in LiCoO2 on the Electrochemical Performance of Garnet-Based All-Solid-State Li-Metal Batteries.","authors":"Zhizhen Qin, Jehad Ahmed, Sebastian Speer, Dmitri L Danilov, Anna Windmüller, Shicheng Yu, Chih-Long Tsai, Hermann Tempel, Josef Granwehr, Wen-Wei Wu, Jeng-Kuei Chang, Rüdiger-A Eichel, Peter H L Notten","doi":"10.1002/advs.202508750","DOIUrl":"https://doi.org/10.1002/advs.202508750","url":null,"abstract":"Garnet-structured Li7La3Zr2O7 (LLZO) is considered as one of the most promising solid electrolytes for high safety all-solid-state Li batteries (SSLBs) applications. However, this type of SSLB utilizing LiCoO2/LLZO as composite cathode faces high capacity degradation because of delamination between LiCoO2 (LCO) and LLZO and possible oxygen vacancy-driven microcrack formation within LCO. Herein, a pure oxygen atmosphere is used for sintering the composite cathode to limit oxygen vacancy formation in LCO. Different sintering temperatures are also used to reduce the effect of sintering atmospheres, which suggests the non-reversible oxidation peak at ∼3.8 V is not related to Li2CO3 formation. Although the Coulombic efficiencies of the first electrochemical cycle of SSLBs sintered in pure oxygen atmosphere are improved, their electrochemical performances are lower than that of air-sintered SSLB due to higher cell resistances from the reduction of oxygen vacancies in LCO and possible higher volume change during electrochemical cycling. Also, the lower electrochemical cycling performance and observing tens of micrometers long inter-granular cracks in the highly dense composite cathode suggests that microstructural optimization is more important than a high relative density. These observations provide guidelines for further improving the electrochemical cycling performance of garnet-structure-based SSLBs toward practical applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08750"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene. 聚四氟乙烯致精子质量下降的治疗修复。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505148

Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang

{"title":"Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene.","authors":"Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang","doi":"10.1002/advs.202505148","DOIUrl":"https://doi.org/10.1002/advs.202505148","url":null,"abstract":"The alarming prevalence of environmental microplastics has raised global concerns about fertility. However, the detriment of polytetrafluoroethylene (PTFE, Teflon), a widely used microplastic in non-stick cookware, to sperm quality remains unclear. Here, a high detection rate (46.62%) and bioaccumulation of PTFE in the male urogenital system are reported and the mechanisms of PTFE exposure on male fertility are investigated in both humans and mice and potential therapeutic strategies are explored. These findings reveal that PTFE exposure delays the development of spermatogonia and spermatocytes, disrupts chromosomal synapsis and the DNA damage response, and promotes the apoptosis of spermatocytes. Interestingly, PTFE exposure specifically targets SKAP2 in the haploid spermatid, leading to disruption of the sperm cytoskeleton, abnormal sperm morphology, and decreased sperm motility. Strikingly, therapy targeting SKAP2 remodels sperm cytoskeleton and morphology and restores sperm motility and male fertility in humans and mice. Collectively, these works illustrate the mechanisms of PTFE exposure impairing spermatogenesis and highlight SKAP2 targeting as a promising therapeutic strategy for treating asthenoteratozoospermia in humans.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05148"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0