Advanced Science最新文献

"Three-in-one" Analysis of Proteinuria for Disease Diagnosis through Multifunctional Nanoparticles and Machine Learning.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-15 DOI: 10.1002/advs.202410751

Yidan Wang, Jiazhu Sun, Jiuhong Yi, Ruijie Fu, Ben Liu, Yunlei Xianyu

{"title":"\"Three-in-one\" Analysis of Proteinuria for Disease Diagnosis through Multifunctional Nanoparticles and Machine Learning.","authors":"Yidan Wang, Jiazhu Sun, Jiuhong Yi, Ruijie Fu, Ben Liu, Yunlei Xianyu","doi":"10.1002/advs.202410751","DOIUrl":"https://doi.org/10.1002/advs.202410751","url":null,"abstract":"Urinalysis is one of the predominant tools for clinical testing owing to the abundant composition, sufficient volume, and non-invasive acquisition of urine. As a critical component of routine urinalysis, urine protein testing measures the levels and types of proteins, enabling the early diagnosis of diseases. Traditional methods require three separate steps including strip testing, protein/creatinine ratio measurement, and electrophoresis respectively to achieve qualitative, quantitative, and classification analyses of proteins in urine with long time and cumbersome operations. Herein, this work demonstrates a \"three-in-one\" protocol to analyze the urine composition by combining multifunctional nanoparticles with machine learning. This work constructs a sensor array to analyze proteinuria by employing nanoparticles with unique optical properties, outstanding catalytic activity, diverse composition, and tunable structure as probes. Different proteins interacted with nanoprobes differently and are classified by this sensor array based on their physicochemical heterogeneities. With the aid of machine learning, the urine composition is precisely detected for the diagnosis of bladder cancer. This protocol enables quantification and classification of 5 proteinuria in 10 min without any tedious pretreatment, showing proimise for the comprehensive analysis of body fluid for early disease diagnosis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2410751"},"PeriodicalIF":14.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionally Graded Oxide Scale on (Hf,Zr,Ti)B₂ Coating with Exceptional Ablation Resistance Induced by Unique Ti Dissolving.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-15 DOI: 10.1002/advs.202411292

Junshuai Lv, Wei Li, Yanqin Fu, Menglin Zhang, Lingxiang Guo, Fanyu Lu, Jiachen Li, Tao Li, Yulei Zhang, Hejun Li

{"title":"Functionally Graded Oxide Scale on (Hf,Zr,Ti)B2 Coating with Exceptional Ablation Resistance Induced by Unique Ti Dissolving.","authors":"Junshuai Lv, Wei Li, Yanqin Fu, Menglin Zhang, Lingxiang Guo, Fanyu Lu, Jiachen Li, Tao Li, Yulei Zhang, Hejun Li","doi":"10.1002/advs.202411292","DOIUrl":"https://doi.org/10.1002/advs.202411292","url":null,"abstract":"Multicomponent Ti-containing ultra-high temperature ceramics (UHTCs) have emerged as more promising ablation-resistant materials than typical UHTCs for applications above 2000 °C. However, the underlying mechanism of Ti improving the ablation performance is still obscure. Here, (Hf,Zr,Ti)B2 coatings are fabricated by supersonic atmospheric plasma spraying, and the effects of Ti content on the ablation performance under an oxyacetylene flame are investigated. The (Hf0.45Zr0.45Ti0.10)B2 coating shows superior ablation resistance and cycling reliability at ≈2200°C. A functionally graded oxide scale comprising an outer dense layer and an underlying fine granular layer formed. The former is a better oxygen barrier owing to fewer cracks and the latter has high strain tolerance due to finer grain size. The uniform dissolving of ≈4 mol% Ti in the inner layer results in grain refinement via sluggish diffusion and thus stress release. For the outer layer, Ti segregation at the nanoscale leads to a metastable cubic (Hf,Zr,Ti)O2 and local severe lattice distortion, inhibiting the propagation of cracks. Ti ions' unique dissolving in the oxide scale enables a strong oxygen diffusion barrier with high strain tolerance, which is responsible for superior performance. This study provides new insights into the ablation behavior of Ti-containing multicomponent UHTCs.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411292"},"PeriodicalIF":14.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-15 DOI: 10.1002/advs.202412300

Siyu Fan, Yue Zhang, Anna P Ainslie, Renée Seinstra, Tao Zhang, Ellen Nollen, Romana Schirhagl

{"title":"In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models.","authors":"Siyu Fan, Yue Zhang, Anna P Ainslie, Renée Seinstra, Tao Zhang, Ellen Nollen, Romana Schirhagl","doi":"10.1002/advs.202412300","DOIUrl":"https://doi.org/10.1002/advs.202412300","url":null,"abstract":"Free radicals are believed to play a secondary role in the cell death cascade associated with various diseases. In Huntington's disease (HD), the aggregation of polyglutamine (PolyQ) not only contributes to the disease but also elevates free radical levels. However, measuring free radicals is difficult due to their short lifespan and limited diffusion range. Here, a quantum sensing technique (T1 relaxometry) is used that involves fluorescent nanodiamonds (FND). Nitrogen vacancy (NV) centers within these nanodiamonds change their optical properties in response to magnetic noise, which allows detecting the unpaired electron from free radicals. This method is used to monitor the production of free radicals inside Caenorhabditis elegans models of Huntington's disease in vivo and in real-time. To investigate if radical generation occurs near polyglutamine expansions, a strain expressing Q40 yellow fluorescent protein (Q40::YFP, polyglutamine expansion overexpressed in the muscle) is used. By applying T1 relaxometry on FNDs in the body wall muscle, it is found that the production of free radicals significantly increase when PolyQ is expressed there (compared to the FNDs in intestine). The technique demonstrates the submicrometer localization of free radical information in living animals and direct measurement of their level, which may reveal the relation between oxidative stress and Huntington's disease.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412300"},"PeriodicalIF":14.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of RuO₂ Nanocrystals with Facile Annealing Method for Enhancing the Electrocatalytic Activity on Overall Water Splitting in Acid Solution. 用简易退火法调节 RuO2 纳米晶体以提高其在酸性溶液中的整体水分离电催化活性。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-15 DOI: 10.1002/advs.202409249

Kangjin Song, Feng Bao, Zheling Wang, Shengding Chang, Na Yao, Haiqing Ma, Yadong Li, Caizhen Zhu, Hong Xia, Fushen Lu, Yibing Song, Jin Wang, Muwei Ji

{"title":"Modulation of RuO2 Nanocrystals with Facile Annealing Method for Enhancing the Electrocatalytic Activity on Overall Water Splitting in Acid Solution.","authors":"Kangjin Song, Feng Bao, Zheling Wang, Shengding Chang, Na Yao, Haiqing Ma, Yadong Li, Caizhen Zhu, Hong Xia, Fushen Lu, Yibing Song, Jin Wang, Muwei Ji","doi":"10.1002/advs.202409249","DOIUrl":"https://doi.org/10.1002/advs.202409249","url":null,"abstract":"RuO2-based materials are considered an important kind of electrocatalysts on oxygen evolution reaction and water electrolysis, but the reported discrepancies of activities exist among RuO2 electrocatalysts prepared via different processes. Herein, a highly efficient RuO2 catalysts via a facile hydrolysis-annealing approach is reported for water electrolysis. The RuO2 catalyst dealt with at 200 °C (RuO2-200) performs the highest activities on both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acid with overpotentials of 200 mV for OER and 66 mV for HER to reach a current density of 100 mA cm-2 as well as stable operation for100 h. The high-resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS) characterizations show that the activities of as-prepared RuO2 rely on the hydroxide group/lattice oxygen (OH-/O2-) ratio, size, and crystalline of RuO2. The density functional theory (DFT) calculation also reveal that the OH- would enhance the activities of RuO2 for HER and OER via modifying the electronic structure to facilitate intermediate adsorption, thereby reducing the energy barrier of the rate-determining step. The water electrolysis by using RuO2-200 as the catalyst on both anode and cathode demonstrates a stable generation of hydrogen and oxygen with high Faradic efficiency at a current density of ≈30 mA cm-2 and a potential of below 1.47 V.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409249"},"PeriodicalIF":14.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica. 利用共价修饰介孔二氧化硅构建可激活的光敏剂

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-15 DOI: 10.1002/advs.202406887

Yan Liu, Xiang Wang, Ben Wang, Zhenni Lu, Changru Wu, Zhanghao He, Libo Jiang, Peng Wei, Tao Yi

{"title":"Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica.","authors":"Yan Liu, Xiang Wang, Ben Wang, Zhenni Lu, Changru Wu, Zhanghao He, Libo Jiang, Peng Wei, Tao Yi","doi":"10.1002/advs.202406887","DOIUrl":"https://doi.org/10.1002/advs.202406887","url":null,"abstract":"The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting the critical issue of PS phototoxicity. In this study, DHUOCl-25, an activatable PS (aPS) activated by hypochlorous acid, is synthesized by combining a silicon source structure and an activation unit. DHUOCl-25 functions as a silica source for synthesizing activatable mesoporous silica nanostrctures (MSNs) using a standardized protocol, enabling the synthesis of aPS-covalently modified MSNs for a variety of biologic therapeutic applications. On one hand, the resulting nano-aPS maintains aPS functionality for antibacterial application by achieving synergistic antibacterial action via MB PDT and retained cetyltrimethylammonium bromide (CTAB) (antibacterial agent) (DHU-MSNs-2). On the other hand, the nano-aPS exhibits MSN properties for drug loading, facilitating the synergistic integration of photodynamic therapy with chemotherapy (DHU-MSNs-6) of tumors and demonstrating efficacy against the spinal metastases of lung cancer. These results validate this strategy for developing novel aPSs and expanding the application of aPSs and MSNs.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2406887"},"PeriodicalIF":14.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202412989

Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

{"title":"Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins.","authors":"Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li","doi":"10.1002/advs.202412989","DOIUrl":"https://doi.org/10.1002/advs.202412989","url":null,"abstract":"The self-assembly of intrinsically disordered proteins (IDPs) into condensed phases and the formation of membrane-less organelles (MLOs) can be considered as the phenomenon of collective behavior. The conformational dynamics of IDPs are essential for their interactions and the formation of a condensed phase. From a physical perspective, collective behavior and the emergence of phase are associated with long-range correlations. Here the conformational dynamics of IDPs and the correlations therein are analyzed, using µs-scale atomistic molecular dynamics (MD) simulations and single-molecule Förster resonance energy transfer (smFRET) experiments. The existence of typical scale-free spatio-temporal correlations in IDP conformational fluctuations is demonstrated. Their conformational evolutions exhibit \"1/f noise\" power spectra and are accompanied by the appearance of residue domains following a power-law size distribution. Additionally, the motions of residues present scale-free behavioral correlation. These scale-free correlations resemble those in physical systems near critical points, suggesting that IDPs are poised at a critical state. Therefore, IDPs can effectively respond to finite differences in sequence compositions and engender considerable structural heterogeneity which is beneficial for IDP interactions and phase formation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412989"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Band Tailoring Enabled Perovskite Devices for X-Ray to Near-Infrared Photodetection.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202414259

Yi-Chu He, Guan-Hua Dun, Jun Deng, Jia-Li Peng, Ken Qin, Jia-He Zhang, Xiang-Shun Geng, Min-Shu Zhang, Ze-Shu Wang, Yan Xie, Zhao-Qiang Bai, Dan Xie, He Tian, Yi Yang, Tian-Ling Ren

{"title":"Band Tailoring Enabled Perovskite Devices for X-Ray to Near-Infrared Photodetection.","authors":"Yi-Chu He, Guan-Hua Dun, Jun Deng, Jia-Li Peng, Ken Qin, Jia-He Zhang, Xiang-Shun Geng, Min-Shu Zhang, Ze-Shu Wang, Yan Xie, Zhao-Qiang Bai, Dan Xie, He Tian, Yi Yang, Tian-Ling Ren","doi":"10.1002/advs.202414259","DOIUrl":"https://doi.org/10.1002/advs.202414259","url":null,"abstract":"Perovskite semiconductors have shown significant promise for photodetection due to their low effective carrier masses and long carrier lifetimes. However, achieving balanced detection across a broad spectrum-from X-rays to infrared-within a single perovskite photodetector presents challenges. These challenges stem from conflicting requirements for different wavelength ranges, such as the narrow bandgap needed for infrared detection and the low dark current necessary for X-ray sensitivity. To address this, this study have designed a type-II FAPbI3 perovskite-based heterojunction featuring a large energy band offset utilizing narrow bandgap tellurium (Te) semiconductor. This innovative design broadens the detection range into the infrared while simultaneously reducing dark current noise. As-designed device allows for the detection of near infrared band, achieving a detectivity of 6.8 × 109 Jones at 1550 nm. The low dark current enables X-ray sensitivity of up to 1885.1 µC Gy⁻¹ cm⁻2. First-principles calculations confirm the type-II band structure alignment of the heterojunction, and a self-driven response behavior is realized. Moreover, this study have developed a scalable 40 × 1 sensor array, demonstrating the potential for wide-spectrum imaging applications. This work is expected to advance the application of perovskite-based wide-spectrum devices.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414259"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multicellular In Vitro Model of the Human Intestine with Immunocompetent Features Highlights Host-Pathogen Interactions During Early Salmonella Typhimurium Infection.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202411233

Spyridon Damigos, Aylin Caliskan, Gisela Wajant, Sara Giddins, Adriana Moldovan, Sabine Kuhn, Evelyn Putz, Thomas Dandekar, Thomas Rudel, Alexander J Westermann, Daniela Zdzieblo

{"title":"A Multicellular In Vitro Model of the Human Intestine with Immunocompetent Features Highlights Host-Pathogen Interactions During Early Salmonella Typhimurium Infection.","authors":"Spyridon Damigos, Aylin Caliskan, Gisela Wajant, Sara Giddins, Adriana Moldovan, Sabine Kuhn, Evelyn Putz, Thomas Dandekar, Thomas Rudel, Alexander J Westermann, Daniela Zdzieblo","doi":"10.1002/advs.202411233","DOIUrl":"https://doi.org/10.1002/advs.202411233","url":null,"abstract":"Studying the molecular basis of intestinal infections caused by enteric pathogens at the tissue level is challenging, because most human intestinal infection models have limitations, and results obtained from animals may not reflect the human situation. Infections with Salmonella enterica serovar Typhimurium (STm) have different outcomes between organisms. 3D tissue modeling of primary human material provides alternatives to animal experimentation, but epithelial co-culture with immune cells remains difficult. Macrophages, for instance, contribute to the immunocompetence of native tissue, yet their incorporation into human epithelial tissue models is challenging. A 3D immunocompetent tissue model of the human small intestine based on decellularized submucosa enriched with monocyte-derived macrophages (MDM) is established. The multicellular model recapitulated in vivo-like cellular diversity, especially the induction of GP2 positive microfold (M) cells. Infection studies with STm reveal that the pathogen physically interacts with these M-like cells. MDMs show trans-epithelial migration and phagocytosed STm within the model and the levels of inflammatory cytokines are induced upon STm infection. Infected epithelial cells are shed into the supernatant, potentially reflecting an intracellular reservoir of invasion-primed STm. Together, the 3D model of the human intestinal epithelium bears potential as an alternative to animals to identify human-specific processes underlying enteric bacterial infections.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411233"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal Coating on Zinc Alloy for Controlled Biodegradation and Improved Osseointegration.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202409051

Yuchien Hsu, Yunjiao He, Xiao Zhao, Feilong Wang, Fan Yang, Yufeng Zheng, Yongsheng Zhou, Dandan Xia, Yunsong Liu

{"title":"Photothermal Coating on Zinc Alloy for Controlled Biodegradation and Improved Osseointegration.","authors":"Yuchien Hsu, Yunjiao He, Xiao Zhao, Feilong Wang, Fan Yang, Yufeng Zheng, Yongsheng Zhou, Dandan Xia, Yunsong Liu","doi":"10.1002/advs.202409051","DOIUrl":"https://doi.org/10.1002/advs.202409051","url":null,"abstract":"Zinc (Zn) and its alloys are promising biomaterials for orthopedic applications due to their degradability and mechanical properties. Zn2+ plays a crucial role in bone formation, but excessive early release may cause cytotoxicity and inhibit osseointegration. To solve this, we developed a near-infrared (NIR) light-controlled polycaprolactone/copper-sulfur (PCL/CuS) coating that slows degradation and enhances osseointegration of Zn alloys. The zinc-lithium (Zn-Li) substrate is encapsulated with PCL, reducing Zn2+ release and maintaing biocompatibility. Controlled Zn2+ release and mild photothermal therapy via CuS nanoparticles promoted osteogenesis. In vitro studies demonstrated enhanced cell proliferation and osteogenic differentiation. In vivo Micro-Computed Tomography (Micro-CT), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and immunohistochemical analyses confirmed improved osseointegration. Mechanistic studies using RNA sequencing and Western blotting revealed that the coating promotes osteogenesis by activating the Wnt/β-catenin and inhibiting NF-κB pathways. This NIR light-controlled PCL/CuS coating successfully regulates Zn alloy degradation, enhances osseointegration via controlled Zn2+ release and mild photothermal therapy effct, presenting a promising avenue for orthopedic biomaterials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409051"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202411985

Caijun Zhao, Lijuan Bao, Ruping Shan, Yihong Zhao, Keyi Wu, Shan Shang, Haiqi Li, Yi Liu, Ke Chen, Naisheng Zhang, Cong Ye, Xiaoyu Hu, Yunhe Fu

{"title":"Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring.","authors":"Caijun Zhao, Lijuan Bao, Ruping Shan, Yihong Zhao, Keyi Wu, Shan Shang, Haiqi Li, Yi Liu, Ke Chen, Naisheng Zhang, Cong Ye, Xiaoyu Hu, Yunhe Fu","doi":"10.1002/advs.202411985","DOIUrl":"https://doi.org/10.1002/advs.202411985","url":null,"abstract":"Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it is unclear whether maternal gut inflammation (MGI) during lactation influences mother-to-infant microbial transmission and offspring microbiota and disease susceptibility. In this study, it is found that MGI during lactation altered the gut microbiota of suckling pups by shaping the maternal microbiota in the gut and mammary glands. MGI-induced changes in the gut microbiota of suckling pups lasted into adulthood, resulting in the exacerbation of acute liver failure (ALF) caused by acetaminophen (APAP) in offspring. Specifically, MGI reduced the abundance of Lactobacillus reuteri (L. reuteri) and its metabolite indole-3-acetic acid (IAA) level in adult offspring. L. reuteri and IAA alleviated ALF in mice by promoting intestinal IL-22 production. Mechanistically, IL-22 limits APAP-induced excessive oxidative stress and ferroptosis by activating STAT3. The intestinal abundances of L. reuteri and IAA are inversely associated with the progression of patients with ALF. Overall, the study reveals the role of MGI in mother-to-infant microbial transmission and disease development in offspring, highlighting potential strategies for intervention in ALF based on the IAA-IL-22-STAT3 axis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411985"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0