Advanced Science最新文献

Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives. 传染病单细胞测序研究进展与展望

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-04 DOI: 10.1002/advs.202415678

Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying

{"title":"Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.","authors":"Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying","doi":"10.1002/advs.202415678","DOIUrl":"https://doi.org/10.1002/advs.202415678","url":null,"abstract":"Infectious diseases are a persistent threat throughout the twenty-first century, owing to their widespread transmission mediated by global connectivity. Benefiting from the advancement of eukaryotic, prokaryotic (e.g., MATQ-seq and BacDrop), and dual (e.g., PatH-Cap) single-cell sequencing technologies, changes in each side and host-pathogen interactions can be elucidated. Pathogens undergo adaptive evolution in the host microenvironment, exhibiting different transcription profiles (e.g., upregulated HSV-1 immediate-early genes during infection), transcription efficiencies, and others. Consequently, they develop distinct replication capacity, virulence, and other phenotypes. For the host, intrinsic differences among cells and variations brought by diverse phenotypic pathogens together determine the heterogeneity of its responses (e.g., the dual roles of interferon-I at different infection stages). Interferon-related pathway alterations (influencing both adaptive and innate immune responses) and cell exhaustion (manifesting as the functional impairment of cells) are observed in various infections, seemingly as a shared approach in host-pathogen interactions. These underlying commonalities provide a basis for the development of broad-spectrum therapeutic targets. Collectively, this work reviewed recent progress of single-cell sequencing technologies and their applications in infectious diseases, aiming to facilitate the development of powerful diagnostic or therapeutic strategies and thus advance precision medicine.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15678"},"PeriodicalIF":14.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Size-Fits-All: A Universal Binding Site for Single-Layer Metal Cluster Self-Assembly. 一刀切：单层金属簇自组装的通用结合位点。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-04 DOI: 10.1002/advs.202508034

Emerson C Kohlrausch, Sadegh Ghaderzadeh, Gazi N Aliev, Ilya Popov, Fatmah Saad, Eman Alharbi, Quentin M Ramasse, Graham A Rance, Mohsen Danaie, Madasamy Thangamuthu, Mathew Young, Richard Plummer, David J Morgan, Wolfgang Theis, Elena Besley, Andrei N Khlobystov, Jesum Alves Fernandes

{"title":"One-Size-Fits-All: A Universal Binding Site for Single-Layer Metal Cluster Self-Assembly.","authors":"Emerson C Kohlrausch, Sadegh Ghaderzadeh, Gazi N Aliev, Ilya Popov, Fatmah Saad, Eman Alharbi, Quentin M Ramasse, Graham A Rance, Mohsen Danaie, Madasamy Thangamuthu, Mathew Young, Richard Plummer, David J Morgan, Wolfgang Theis, Elena Besley, Andrei N Khlobystov, Jesum Alves Fernandes","doi":"10.1002/advs.202508034","DOIUrl":"https://doi.org/10.1002/advs.202508034","url":null,"abstract":"2D metal clusters maximize atom-surface interactions, making them highly attractive for energy and electronic technologies. However, their fabrication remains extremely challenging because they are thermodynamically unstable. Current methods are limited to element-specific binding sites or confinement of metals between layers, with no universal strategy achieved to date. Here, a general approach is presented that uses vacancy defects as universal binding sites to fabricate single-layer metal clusters (SLMC). It is demonstrated that the density of these vacancies governs metal atom diffusion and bonding to the surface, overriding the metal's physicochemical properties. Crucially, the reactivity of vacancy sites must be preserved prior to metal deposition to enable SLMC formation. This strategy is demonstrated across 21 elements and their mixtures, yielding SLMC with areal densities up to 4.3 atoms∙nm⁻2, without heteroatom doping, while maintaining high thermal, environmental, and electrochemical stability. These findings provide a universal strategy for stabilizing SLMC, eliminating the need for element-specific synthesis and metal confinement protocols and offering a strategy for efficiently utilizing metals.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08034"},"PeriodicalIF":14.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescent Platform for Thermal Sensing and Imaging Based on Structural Phase-Transition. 基于结构相变的热传感与成像发光平台。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-04 DOI: 10.1002/advs.202508920

Anam Javaid, Maja Szymczak, Malgorzata Kubicka, Vasyl Kinzhybalo, Marek Drozd, Damian Szymanski, Lukasz Marciniak

{"title":"Luminescent Platform for Thermal Sensing and Imaging Based on Structural Phase-Transition.","authors":"Anam Javaid, Maja Szymczak, Malgorzata Kubicka, Vasyl Kinzhybalo, Marek Drozd, Damian Szymanski, Lukasz Marciniak","doi":"10.1002/advs.202508920","DOIUrl":"https://doi.org/10.1002/advs.202508920","url":null,"abstract":"The luminescent properties of Eu3+ ions are highly sensitive to changes in their local crystal environment. While this feature has been widely studied, its application in thermometers based on thermally induced structural phase transitions is a recent development. These thermometers often suffer from a narrow thermal operating range, prompting the search for new host materials. In this context, Na3Sc2(PO4)3:Eu3+ as a function of temperature and dopant ion concentration. As demonstrated, Na3Sc2(PO4)3:Eu3+ was investigated as a potential candidate. This material undergoes a reversible phase transition from a monoclinic to a trigonal structure, leading to significant changes in both the emission spectra and the luminescence decay of Eu3+ ions. These effects enable the development of both ratiometric and lifetime-based luminescent thermometers, achieving maximum relative sensitivities of 3.4% K-1 and 1.0% K-1, respectively. Furthermore, the thermal operating range can be tuned by adjusting the Eu3+ concentration. Importantly, this study demonstrates, for the first time, temperature imaging using only Eu3+-doped phosphor via a digital camera without the use of optical filters. These results position Na3Sc2(PO4)3:Eu3+ as a promising multifunctional material for advanced applications in contactless temperature sensing and thermal imaging.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08920"},"PeriodicalIF":14.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topology Augmented with Geometry in the Assembly of Structural Databases: Kagome Intermetallics. 结构数据库装配中的拓扑扩充与几何：Kagome金属间化合物。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-04 DOI: 10.1002/advs.202417041

Nataliya L Gulay, Dongsheng Wen, Joshua E Griffiths, Judith Clymo, Luke M Daniels, Jonathan Alaria, Matthew S Dyer, John B Claridge, Matthew J Rosseinsky

{"title":"Topology Augmented with Geometry in the Assembly of Structural Databases: Kagome Intermetallics.","authors":"Nataliya L Gulay, Dongsheng Wen, Joshua E Griffiths, Judith Clymo, Luke M Daniels, Jonathan Alaria, Matthew S Dyer, John B Claridge, Matthew J Rosseinsky","doi":"10.1002/advs.202417041","DOIUrl":"https://doi.org/10.1002/advs.202417041","url":null,"abstract":"Creation of well-curated databases tailored to specific structural motifs can underpin and drive materials discovery, as the properties of materials are governed by composition and structure. The role of such motifs in directing the intricate interplay between structure and properties is exemplified by intermetallic compounds with structures that contain kagome layers that exhibit a variety of exotic physical states. Two prevailing approaches have previously been applied to identify such materials: evaluation of structural topology or geometry assessment, however, both present limitations if deployed individually. We augment topological screening with geometrical filtering to allow versatile control over the identification of kagome layers. Applying this approach with minimal further constraints labels over 9000 kagome-containing intermetallics which are assigned to four structural classes, revealing connections between symmetry, composition, direct space structure, and flatband electronic structures in reciprocal space. A machine learning model is used to predict new element combinations that favour the formation of kagome layers. Several highly-ranked phase fields correspond to known kagome-containing materials that were absent from the training dataset, demonstrating that the workflow can identify chemistries affording kagome layers. This motivates the extension of the approach beyond kagome to other property-conferring motifs, such as honeycomb, square planar or triangular plane nets.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e17041"},"PeriodicalIF":14.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "A Dual-Response DNA Origami Platform for Imaging and Treatment of Sepsis-Associated Acute Kidney Injury". 修正“用于脓毒症相关急性肾损伤成像和治疗的双反应DNA折纸平台”。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-04 DOI: 10.1002/advs.202510994

引用次数: 0

Choroid Plexus Fibroblast-ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury. 脉络膜丛成纤维细胞ilc2小基促进创伤性脑损伤后成体海马神经发生。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-03 DOI: 10.1002/advs.202415984

Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong

{"title":"Choroid Plexus Fibroblast-ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury.","authors":"Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong","doi":"10.1002/advs.202415984","DOIUrl":"https://doi.org/10.1002/advs.202415984","url":null,"abstract":"Mounting evidence has indicated that immune signals originating from the brain's border tissues will exert a profound influence on brain parenchyma neural cells. However, the structural component alterations and immune cell infiltration characteristics of choroid plexus (ChP) following traumatic brain injury (TBI) remain incompletely understood. Here, using single-cell RNA sequencing and histological analysis, the accumulation of group 2 innate lymphoid cell (ILC2) in the ChP stroma post-TBI is identified. Intracerebroventricular adoptive transfer of ILC2 is further indicated to exhibit a tendency to colonize the ChP and significantly alleviate pathogenic immune infiltration during the acute phase of TBI, as well as maintain hippocampal integrity during the chronic phase. Sensory-motor function and memory impairments in TBI mice are also improved under ILC2 treatment. Mechanistically, ILC2 is induced by ChP fibroblasts derived IL33 and anchored to stroma fibroblasts via the VCAM-1/Integrin α4β7 pathway. Furthermore, single-nucleus RNA sequencing of the hippocampus reveals that ILC2-derived AREG promotes the initiation of neurogenesis by interacting with EGFR on early-stage neurogenic cells. Overall, these findings highlight that ChP-resident ILC2, through optimizing the immune microenvironment and promoting neurogenesis after TBI, may represent a potential therapeutic strategy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15984"},"PeriodicalIF":14.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interface Controlled Electric Field Swing Adsorption. 界面控制电场摆动吸附。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-03 DOI: 10.1002/advs.202504617

Silvio Heinschke, Jörg J Schneider

{"title":"Interface Controlled Electric Field Swing Adsorption.","authors":"Silvio Heinschke, Jörg J Schneider","doi":"10.1002/advs.202504617","DOIUrl":"https://doi.org/10.1002/advs.202504617","url":null,"abstract":"Influencing the adsorptive processes of gases by external stimuli is an ongoing research task of academic and technological relevance. Technologically external stimuli like pressure, vacuum, temperature, magnetic field, or electrical phenomena are the most common ones with which adsorptive and desorptive processes can be influenced. In the case of pure electric field swing adsorption (EFSA) of solid/gas mixtures, however, experimental knowledge concerning carbon materials is lacking so far. A new approach to the electrical field effect on gas adsorption and desorption is presented. Ar, N2 and CO2 interact with an all-solid composite material composed of activated porous carbon and silica characterized by a high amount of charged interfaces under isothermal conditions and ambient temperature. The intimate contact of both components in the composite allows for the formation of multiple resistor-conductor interfaces enabling the reversible physisorption of these gases using electric fields in the lower V and mA range. The adsorptive/desorptive swing effect depends on the polarizabilities of the gases in particular their dipoles and to an even larger extent on the field induced quadrupole moments of the probe gases Ar, N2 and CO2.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04617"},"PeriodicalIF":14.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data-Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties. 基于流变性能的精确直墨书写水凝胶的数据驱动打印性建模。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-03 DOI: 10.1002/advs.202507639

Eun Hui Jeong, Jiho Choi, Han Bi Park, Ji Woo Lee, Seo Yeon Bae, Byoung Soo Kim, ChangKyu Yoon, Jun Dong Park

{"title":"Data-Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties.","authors":"Eun Hui Jeong, Jiho Choi, Han Bi Park, Ji Woo Lee, Seo Yeon Bae, Byoung Soo Kim, ChangKyu Yoon, Jun Dong Park","doi":"10.1002/advs.202507639","DOIUrl":"https://doi.org/10.1002/advs.202507639","url":null,"abstract":"Hydrogels are gaining significant attention in soft robotics and electronics due to their favorable mechanical properties and sustainability. While hydrogel inks enable three-dimensional (3D) printing as a key fabrication technique, the relationship between their rheological behavior and printability remains insufficiently understood. This study quantitatively examines this correlation through a rheology-printability database of 150 3D-printed hydrogels analyzed via machine learning. The database includes nonlinear rheological metrics, such as large-amplitude oscillatory shearing (LAOS), which mimic real 3D printing conditions involving repeated flow and stoppage. Printability is quantitatively evaluated in horizontal and vertical directions and inconsistency through image analysis of 3D printed structures. A predictive model for printability is developed using Random Forest regression, achieving reliable predictions within a 10% margin. Permutation importance analysis suggested that horizontal printability is primarily influenced by variables related to post-extrusion recovery and relaxation process, whereas vertical printability is mainly governed by viscous responses under high-strain-rate flow through the nozzle. Overall, this study provides quantitative insights into the intricate relationship between hydrogel rheology and 3D printability, paving the way for the sustainable design of hydrogel inks and their 3D printing processes for the precise fabrication of soft robotics structures and electronics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07639"},"PeriodicalIF":14.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy (Adv. Sci. 25/2025) 自推进原位聚合纳米颗粒激活STING通路增强膀胱癌免疫治疗（Adv. Sci. 25/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-03 DOI: 10.1002/advs.202570190

Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu

引用次数: 0

Surface Engineering-Induced d-Band Center Down-Regulation in High-Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis (Adv. Sci. 25/2025) 表面工程诱导的高熵合金纳米线d波段中心下调对纳米酶催化的影响（硕士论文，25/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-03 DOI: 10.1002/advs.202570195

Kunyang Feng, Hanting Wang, Song Zhou, Wei Zhang, Chonghai Gong, Yuxin He, Yusen Wang, Wenchong Dai, Jianbo Li, Zhengwei Zhang, Siqiao Li

引用次数: 0