Advanced Science最新文献_第2页

RETRACTION: Direct Formation of Hard-Magnetic Tetrataenite in Bulk Alloy Castings. 返回：块状合金铸件中硬磁性四钛铁矿的直接形成。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202416229

引用次数: 0

Advancing Multi-Ion Sensing with Poly-Octylthiophene: 3D-Printed Milker-Implantable Microfluidic Device (Adv. Sci. 47/2024)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470291

Md. Azahar Ali, Matin Ataei Kachouei

引用次数: 0

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202409930

Wenzhuo Fang, Ying Wang, Kaile Zhang, Ming Yang, Meng Liu, Yangwang Jin, Xianjie Xiu, Yuhui Wang, Zhenwei Yu, Ranxing Yang, Qiang Fu

{"title":"An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction.","authors":"Wenzhuo Fang, Ying Wang, Kaile Zhang, Ming Yang, Meng Liu, Yangwang Jin, Xianjie Xiu, Yuhui Wang, Zhenwei Yu, Ranxing Yang, Qiang Fu","doi":"10.1002/advs.202409930","DOIUrl":"https://doi.org/10.1002/advs.202409930","url":null,"abstract":"The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole-process repair hydrogel (APF/C/L@dECM) is designed. After rigorous testing, it is found that hydrogels formed by hydrophobic association and double cross-linking of amide bonds can procedurally regulate wound healing in all phases to match the repair process. In rabbit models of urethral wound, APF/C/L@dECM hydrogel can achieve scarless reconstruction with significantly better results than other hydrogels. Noteworthily, multi-stage mechanistic explorations reveal the expression profiles of inflammation, vascularization, and extracellular matrix secretion-related genes in wound tissue at different times. In summary, this study develops an overall treatment for urethral injury through a whole-process repair system that promotes healthy healing of urethral wounds and prevents the formation of scar tissue.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409930"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma. 靶向 piRNA-137463 通过新胆固醇合成抑制肺腺癌的肿瘤进展并提高对免疫检查点阻断剂的敏感性

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202414100

Yuning Zhan, Fanglin Tian, Weina Fan, Xin Li, Xiangyu Wang, Hongxia Zhang, Xin Hong, Xin Wang, Li Cai, Yang Song, Ying Xing

{"title":"Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma.","authors":"Yuning Zhan, Fanglin Tian, Weina Fan, Xin Li, Xiangyu Wang, Hongxia Zhang, Xin Hong, Xin Wang, Li Cai, Yang Song, Ying Xing","doi":"10.1002/advs.202414100","DOIUrl":"https://doi.org/10.1002/advs.202414100","url":null,"abstract":"The important role of PIWI-interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA-137463 have been linked to poor prognosis in LUAD patients. Inhibition of piRNA-137463 curbed the proliferation, migration, and invasion of LUAD cells, enhanced T cell cytotoxicity through increased IFN-γ secretion, disrupted cholesterol metabolism, and reduced intracellular cholesterol, lipid raft content, and PD-L1 expression in LUAD cells. Bioinformatic prediction identified a potential interaction between piRNA-137463 and lncRNA LOC100128494. Inhibiting piRNA-137463 increased the stability and expression of LOC100128494, which further modulated insulin-induced gene 1 protein (INSIG1) levels via a competitive endogenous RNA network involving LOC100128494 and miR-24-3p. Notably, the effect of piRNA-137463 in LUAD cells is dependent on the expression of LOC100128494 and INSIG1. Inhibiting the expression of piRNA-137463 with AntagopiRNA-137463 suppressed tumor growth and metastasis via LOC100128494 in nude mice and enhanced the response of LUAD to anti-PD-1 therapy in immune-competent mice. In summary, this study elucidates the role of piRNA-137463 in the reprogramming of cholesterol metabolism, which drives the progression of LUAD, thereby identifying a new target for the comprehensive clinical management of LUAD.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414100"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubulin-Based Microtentacles Aid in Heterotypic Clustering of Neutrophil-Differentiated HL-60 Cells and Breast Tumor Cells.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202409260

Julia A Ju, Keyata N Thompson, David A Annis, Makenzy L Mull, Darin E Gilchrist, Aidan Moriarty, Katarina T Chang, Megan B Stemberger, Michael J Noto, Michele I Vitolo, Stuart S Martin

{"title":"Tubulin-Based Microtentacles Aid in Heterotypic Clustering of Neutrophil-Differentiated HL-60 Cells and Breast Tumor Cells.","authors":"Julia A Ju, Keyata N Thompson, David A Annis, Makenzy L Mull, Darin E Gilchrist, Aidan Moriarty, Katarina T Chang, Megan B Stemberger, Michael J Noto, Michele I Vitolo, Stuart S Martin","doi":"10.1002/advs.202409260","DOIUrl":"https://doi.org/10.1002/advs.202409260","url":null,"abstract":"Circulating tumor cells (CTCs) travel through the vasculature to seed secondary sites and serve as direct precursors of metastatic outgrowth for many solid tumors. Heterotypic cell clusters form between CTCs and white blood cells (WBCs) and recent studies report that a majority of these WBCs are neutrophils in patient and mouse models. The lab discovered that CTCs produce tubulin-based protrusions, microtentacles (McTNs), which promote reattachment, retention in distant sites during metastasis and formation of tumor cell clusters. Neutrophil-CTC clusters help CTCs survive the harsh vascular environment to promote successful metastasis, however, the specific mechanism of this interaction is not fully understood. Utilizing TetherChip technology, it is found that primary and differentiated neutrophils produce McTNs composed of detyrosinated and acetylated α-tubulin and vimentin. Neutrophil McTNs aid in cluster formation, migration, and reattachment, which are suppressed with the tubulin-depolymerizing agent, Vinorelbine. Co-culturing differentiated neutrophils and tumor cells formed heterotypic clusters that enhanced migration. CTC-neutrophil clusters have higher metastatic efficiency, and by demonstrating that neutrophils form McTNs, a new possible mechanism for how neutrophils interact with tumor cells is revealed. These findings further support the idea that developing cluster-disrupting therapies can provide a new targeted strategy to reduce the metastatic potential of cancer cells.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409260"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RGB-Single-Chip OLEDs for High-Speed Visible-Light Communication by Wavelength-Division Multiplexing (Adv. Sci. 47/2024)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470290

Kou Yoshida, Cheng Chen, Harald Haas, Graham A. Turnbull, Ifor D. W. Samuel

引用次数: 0

A Non-Invasive and DNA-free Approach to Upregulate Mammalian Voltage-Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation (Adv. Sci. 47/2024)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470292

Yuankun Sun, Jinli Geng, Yu Fan, Yangmei Li, Yuan Zhong, Jing Cai, Xiaodong Liu, Shaomeng Wang, Yubin Gong, Chao Chang, Yaxiong Yang, Chunhai Fan

引用次数: 0

Masthead: (Adv. Sci. 47/2024)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470289

引用次数: 0

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants. 条条大路通罗马：植物抗病工程的途径。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202412223

Aziz Ul Ikram, Muhammad Saad Shoaib Khan, Faisal Islam, Sulaiman Ahmed, Tengfang Ling, Feng Feng, Zongtao Sun, Huan Chen, Jian Chen

{"title":"All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.","authors":"Aziz Ul Ikram, Muhammad Saad Shoaib Khan, Faisal Islam, Sulaiman Ahmed, Tengfang Ling, Feng Feng, Zongtao Sun, Huan Chen, Jian Chen","doi":"10.1002/advs.202412223","DOIUrl":"https://doi.org/10.1002/advs.202412223","url":null,"abstract":"Unlike animals, plants are unable to move and lack specialized immune cells and circulating antibodies. As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. Therefore, the development of new strategies to control them is essential to mitigate the increasing risk of crops lost to plant diseases. Recent developments in genetic engineering, including efficient gene manipulation and transformation methods, gene editing and synthetic biology, coupled with the understanding of microbial pathogenicity and plant immunity, both at molecular and genomic levels, have enhanced the capabilities to develop disease resistance in plants. This review comprehensively explains the fundamental mechanisms underlying the tug-of-war between pathogens and hosts, and provides a detailed overview of different strategies for developing disease resistance in plants. Additionally, it provides a summary of the potential genes that can be employed in resistance breeding for key crops to combat a wide range of potential pathogens and pests, including fungi, oomycetes, bacteria, viruses, nematodes, and insects. Furthermore, this review addresses the limitations associated with these strategies and their possible solutions. Finally, it discusses the future perspectives for producing plants with durable and broad-spectrum disease resistance.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412223"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Anticancer Drug Discovery: Leveraging Metabolomics and Machine Learning for Mode of Action Prediction by Pattern Recognition (Adv. Sci. 47/2024)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470288

Mohamad Saoud, Jan Grau, Robert Rennert, Thomas Mueller, Mohammad Yousefi, Mehdi D. Davari, Bettina Hause, René Csuk, Luay Rashan, Ivo Grosse, Alain Tissier, Ludger A. Wessjohann, Gerd U. Balcke

引用次数: 0