Advanced Science最新文献_第2页

Domain-Wall Driven Suppression of Thermal Conductivity in a Ferroelectric Polycrystal. 畴壁驱动对铁电多晶热导率的抑制。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202506931

Rachid Belrhiti-Nejjar, Manuel Zahn, Patrice Limelette, Max Haas, Lucile Féger, Isabelle Monot-Laffez, Nicolas Horny, Dennis Meier, Fabien Giovannelli, Jan Schultheiß, Guillaume F Nataf

{"title":"Domain-Wall Driven Suppression of Thermal Conductivity in a Ferroelectric Polycrystal.","authors":"Rachid Belrhiti-Nejjar, Manuel Zahn, Patrice Limelette, Max Haas, Lucile Féger, Isabelle Monot-Laffez, Nicolas Horny, Dennis Meier, Fabien Giovannelli, Jan Schultheiß, Guillaume F Nataf","doi":"10.1002/advs.202506931","DOIUrl":"https://doi.org/10.1002/advs.202506931","url":null,"abstract":"A common strategy for reducing the thermal conductivity of polycrystalline systems is to increase the number of grain boundaries. Indeed, grain boundaries enhance the probability of phonon scattering events, which has been applied to control the thermal transport in a wide range of materials, including hard metals, diamond, oxides, and two-dimensional (2D) systems such as graphene. Here, the opposite behavior in improper ferroelectric ErMnO3 polycrystals is reported, where the thermal conductivity decreases with increasing grain size. This unusual relationship between heat transport and microstructure is attributed to phonon scattering at ferroelectric domain walls. The domain walls are more densely packed in larger grains, leading to an inversion of the classical grain-boundary-dominated transport behavior. The findings open additional avenues for microstructural engineering of materials for thermoelectric and thermal management applications, enabling simultaneous control over mechanical, electronic, and thermal properties.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06931"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics. RAB5A通过重编程乳腺癌球体力学促进主动润湿。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202503569

Grégoire Lemahieu, Paulina Moreno-Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez-González, Federica Pennarola, Federico Colombo, Andrew E Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon-Luca Homagk, Samuel F H Barnett, Alexander X Cartagena-Rivera, Christine Selhuber-Unkel, Robert Prevedel, Xavier Trepat, Joachim P Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti-Adam

{"title":"RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.","authors":"Grégoire Lemahieu, Paulina Moreno-Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez-González, Federica Pennarola, Federico Colombo, Andrew E Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon-Luca Homagk, Samuel F H Barnett, Alexander X Cartagena-Rivera, Christine Selhuber-Unkel, Robert Prevedel, Xavier Trepat, Joachim P Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti-Adam","doi":"10.1002/advs.202503569","DOIUrl":"https://doi.org/10.1002/advs.202503569","url":null,"abstract":"Unjamming transitions from a solid-like to a fluid-like state are a gateway to breast epithelial cancer invasion. However, the mechanical interplay between phase transitions and dimension transitions, in particular wetting, remains elusive, despite being critical for understanding the onset of metastatic dissemination. This study shows that unjamming, mediated by the RAB5A GTPase, alters carcinoma spheroid fluidity, rigidity, and rewires adhesion mechanics to drive supracellular active wetting as a new mode of tumor expansion. Spheroid fluidification enhances the selective expression of integrin subunits and increases focal adhesion dynamics, inducing a fluid-like spreading behavior on specific matrix ligands. Notably, nanoscale regulation of integrin clustering can select for distinct phase transitions at the collective scale upon wetting. In this framework, fluidized spheroids polarize into cohesive \"supracells\", and maintain a stiff peripheral actin bundle as measured by nanomechanical mapping. Furthermore, a combination of Brillouin microscopy and 2.5D traction force analysis reveals a mechanical switch within the spheroid core, characterized by significant cell softening and a reduction in compressive forces exerted on the substrate, thereby mimicking the wetting of a liquid droplet. These findings establish unjamming-driven active wetting as a key mechanism to comprehend the molecular and biophysical underpinnings of solid tumor invasion.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03569"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Bacteria-Based Cancer Immunotherapy: Comment on "Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics". 探索以细菌为基础的癌症免疫治疗：对“肿瘤内溶瘤细菌靶向抗癌治疗的发现”的评论。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202506869

Chen-Xi Li, Zhong-Cheng Gong

引用次数: 0

Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation. 通过SLC7A11-INF2轴诱导的葡萄糖剥夺诱导的双侧下垂：泛癌症预后探索和治疗验证。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202408556

Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu

{"title":"Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation.","authors":"Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu","doi":"10.1002/advs.202408556","DOIUrl":"https://doi.org/10.1002/advs.202408556","url":null,"abstract":"Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets. Recent multi-omics studies highlight the prognostic value of disulfidptosis-related gene (DRG) signatures in pan-cancers; however, the molecular mechanisms underlying their biological functions and therapeutic relevance remain poorly defined. Herein, a DRG score model is constructed using LASSO Cox regression across 33 cancer types, and a nomogram incorporating the DRG score is developed for prognostic prediction. The tumor microenvironment, mutation profiles, and immunotherapy responses are analyzed. The DRG score serves as an independent prognostic factor across cancers, correlating with poor outcomes and malignant features. Glucose deprivation induces disulfidptosis in SLC7A11high cells (high SLC7A11 expression), especially in cancers with a high DRG score, such as ovarian cancer. Silencing INF2 prevents disulfidptosis and decreases susceptibility to irofulven, which can be reversed by GLUT inhibitors. SLC7A11 knockdown reduces disulfidptosis, restores ATP/NADPH levels, and protects the cytoskeleton under glucose deprivation, whereas INF2 knockdown impairs cell migration. Moreover, the DRG scores predict prognosis and therapeutic responses. The SLC7A11-INF2 axis regulates disulfidptosis, migration, and drug sensitivity, highlighting its potential as a marker of metabolic vulnerability in ovarian cancer.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08556"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Electron Charge Carrier Mobility in the Nematic Phase of a Roof-Shaped Nematogen with Optimum Molecular Biaxiality. 具有最佳分子双轴性的屋顶状线虫的向列相中高载流子迁移率。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202510009

Matthias Lehmann, Nikolai Scheuring, Loïc Mager, Dharmendra Pratap Singh, Richard Mandle, Alexey Eremin

引用次数: 0

Observation of Magnetic Pseudogap Behavior in Phosphorus-Doped Silicon. 掺磷硅中磁赝隙行为的观察。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202502789

Suheon Lee, Sangeun Cho, Yongcheol Jo, Wonjun Lee, Jae Min Kim, Hong Gu Lee, Yugo Oshima, Taku Matsushita, Hiroki Ikegami, Jonas A Krieger, Christoper Baines, Thomas J Hicken, Hubertus Luetkens, Eundeok Mun, Jungseek Hwang, Hyunsik Im, Kwang-Yong Choi

{"title":"Observation of Magnetic Pseudogap Behavior in Phosphorus-Doped Silicon.","authors":"Suheon Lee, Sangeun Cho, Yongcheol Jo, Wonjun Lee, Jae Min Kim, Hong Gu Lee, Yugo Oshima, Taku Matsushita, Hiroki Ikegami, Jonas A Krieger, Christoper Baines, Thomas J Hicken, Hubertus Luetkens, Eundeok Mun, Jungseek Hwang, Hyunsik Im, Kwang-Yong Choi","doi":"10.1002/advs.202502789","DOIUrl":"https://doi.org/10.1002/advs.202502789","url":null,"abstract":"The recent discovery of a Kondo condensate in phosphorus-doped silicon (Si:P) presents its significant potential for achieving novel many-body quantum states. Si:P exhibits Kondo condensation, characterized by an energy gap in the electronic density of states, while the precise nature of its magnetic state has yet to be determined. Here, we utilize electron and muon spin resonance (ESR and µSR) techniques, optical spectroscopy, and specific heat measurements to unravel the magnetic ground state and spin dynamics of Si:P. Both optical and ESR spectroscopy reveal the onset of spin correlations below 150 K. Furthermore, the muon spin relaxation rate exhibits a power-law increase, λZF∼T-0.26(5), below TKC ≈ 0.2 K, indicating the emergence of critical spin fluctuations within the Kondo condensate state. Strikingly, the concomitant occurrence of a Bardeen-Cooper-Schrieffer-like charge gap and power-law magnetic fluctuations closely parallels the pseudogap phases observed in doped Mott insulators. These findings evince that the critical spin fluctuations of the Kondo condensate state act as a driving force for pseudogap formation within inhomogeneous Kondo clouds.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02789"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection. 研究SARS-CoV-2感染后巨噬细胞介导的肺细胞衰老的人免疫-肺类器官模型

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202503932

Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen

{"title":"A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.","authors":"Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen","doi":"10.1002/advs.202503932","DOIUrl":"https://doi.org/10.1002/advs.202503932","url":null,"abstract":"While COVID-19 affects multiple organ systems, the human respiratory system is the primary viral target and main site for disease progression. In this study, spatial transcriptional assays (NanoString CosMx) are utilized to analyze both explant and autopsy samples from non-COVID and COVID-19 lungs, identifying the activation of proinflammatory macrophages in COVID-19 explants. It is further developed immuno-lung organoids comprising hPSC-derived alveolar and airway organoids co-cultured with macrophages to investigate the impact and underlying mechanisms of macrophage-mediated lung damage following SARS-CoV-2 infection. The findings demonstrate that proinflammatory macrophages induce lung cell senescence through the THBS1-(ITGA3+ITGB1) signaling axis, a mechanism further validated using spatial transcriptomics. This study not only establishes physiologically relevant immuno-lung organoid models for modeling macrophage-mediated tissue damage, but also identifies a previous unrecognized role of the THBS1-(ITGA3+ITGB1) pathway in driving lung cell senescence during infectious disease.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03932"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing z Spin Generation in Trivial Spin Hall Materials for Scalable, Energy-Efficient, Field-Free, Complete Spin-Orbit Torque Switching Applications. 在可扩展、高能效、无场、完全自旋-轨道转矩开关应用中增强平凡自旋霍尔材料中的z自旋产生。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202507581

Qianbiao Liu, Lijun Zhu

{"title":"Enhancing z Spin Generation in Trivial Spin Hall Materials for Scalable, Energy-Efficient, Field-Free, Complete Spin-Orbit Torque Switching Applications.","authors":"Qianbiao Liu, Lijun Zhu","doi":"10.1002/advs.202507581","DOIUrl":"https://doi.org/10.1002/advs.202507581","url":null,"abstract":"Despite the remarkable efforts in the past two decades, it has remained a major challenge to achieve switching of perpendicularly magnetized spin-orbit torque devices in a scalable, energy-efficient, field-free, integration-friendly, and complete manner. Here, a giant enhancement of z spin generation in low-resistivity spin Hall metal/FeCoB devices is reported by alloying the spin Hall metal Pt with Ti and by electric asymmetry engineering. The damping-like spin torques of z spins and y spins are enhanced by 6 and 3 times relative to those of conventional Pt/FeCoB and enable complete, record-low-power, deterministic switching of FeCoB devices with strong perpendicular magnetic anisotropy and high coercivity. The Pt75Ti25/FeCoB heterostructure also exhibits relatively low resistivity, wafer-scale uniform sputterdeposition on silicon oxide, good compatibility with magnetic tunnel junctions, and excellent thermal stability of exceeding 400 °C. These results unambiguously establish the Pt75Ti25/FeCoB as the most compelling candidate for solving the bottleneck of scalable, energy-efficient, field-free, integration-friendly, and complete spin-orbit torque switching technologies. This work also provides a universal strategy for developing high-performance generators of z-spin current and will stimulate the exploration of exotic spin currents by alloying \"trivial\" spin Hall materials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07581"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment. 基于生物材料的肺疾病mRNA传递系统的研究

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505413

Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi

{"title":"Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment.","authors":"Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi","doi":"10.1002/advs.202505413","DOIUrl":"https://doi.org/10.1002/advs.202505413","url":null,"abstract":"Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery. Various biomaterials-including nanoparticles such as liposomes, polymers, hybrid systems, dendritic polymers, gold nanoparticles, mesoporous silica, calcium carbonate, and exosomes-exhibit excellent biocompatibility. These materials protect therapeutic agents from nuclease degradation, stabilize drug carriers, and enhance cellular uptake via mechanisms such as endocytosis. Chemical modifications further improve biomaterials by facilitating endosomal escape and conjugation with targeting ligands, thereby enabling precise delivery to specific cells or tissues. As a therapeutic modality, mRNA offers high biosafety, notable controllability, efficient translation, and immunomodulatory properties. This review evaluates the impact of lung structure on drug absorption, examines delivery mechanisms associated with various biomaterial types, and presents application examples. It also summarizes recent research developments, discusses clinical limitations, and explores future research directions for biomaterials in lung disease therapy. Additionally, it highlights the role of biomaterials in stabilizing and protecting mRNA, providing insights into the advancement of mRNA-based therapeutics. This review aims to establish a robust theoretical foundation and offer practical guidance for biomaterial-based mRNA therapies in treating lung diseases.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05413"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ""Cicada Out of the Shell" Deep Penetration and Blockage of the HSP90 Pathway by ROS-Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy". “破壳蝉”ros反应性超分子凝胶深度穿透和阻断HSP90通路以增强三模态协同治疗”的更正。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202512868

引用次数: 0