Advanced Science最新文献_第2页

High-Speed Design of Multiplexed Meta-Optics Enabled by Physics-Driven Self-Supervised Network. 基于物理驱动自监督网络的复用元光学高速设计。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202509242

Yuqing He, Sheng Ye, Yue Han, Mingna Xun, Qiang Li, Ruiqi Wang, Qihuang Gong, Yan Li

{"title":"High-Speed Design of Multiplexed Meta-Optics Enabled by Physics-Driven Self-Supervised Network.","authors":"Yuqing He, Sheng Ye, Yue Han, Mingna Xun, Qiang Li, Ruiqi Wang, Qihuang Gong, Yan Li","doi":"10.1002/advs.202509242","DOIUrl":"https://doi.org/10.1002/advs.202509242","url":null,"abstract":"The artificial intelligence (AI) can accelerate the meta-optics design by rapidly predicting the transmission coefficients of individual meta-atoms. However, extensive optimization iterations are usually required to complete the desired metasurface consisting of massive meta-atoms. For designing meta-holography, any change to the target image forces the whole process to repeat, resulting in lengthy computation time. Here, a physics-driven self-supervised network (PDSS-Net) built upon AI-assisted optimization frameworks are proposed to further expedite the design process. The encoder-decoder module introduced into the PDSS-Net can establish a mapping between the input holographic images and the output structural parameters of all meta-atoms. After self-supervised training, the network learns this mapping and enables iteration-free inference for inputs beyond the training dataset. The design of 2K-resolution, three-wavelength-multiplexed meta-holograms is completed within one second, achieving a computational speedup exceeding 1000-fold over conventional optimization-based approaches. By retraining, more complex tasks are achieved as demonstrated in the design of both the wavelength-polarization-depth multiplexed scalar and vectorial meta-holograms. This iteration-free computational paradigm with adaptability in typical multiplexed meta-optics can be applied to the intelligent design of multifunctional metasurfaces, facilitating large-scale applications of meta-devices.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09242"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfigurable In-S Coordination in SPAN Cathodes: Unlocking High Sulfur Utilization and Fast Kinetics for Practical Li‒S Batteries. SPAN阴极中的可重构in - s配位：解锁实用锂电池的高硫利用率和快速动力学。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202507385

Cheng Huang, Yi Gong, Qi Zhu, Miaoran Xu, Kai Yang, José V Anguita, Wei Zhang, S Ravi P Silva, Yanfeng Gao, Zongtao Zhang

{"title":"Reconfigurable In-S Coordination in SPAN Cathodes: Unlocking High Sulfur Utilization and Fast Kinetics for Practical Li‒S Batteries.","authors":"Cheng Huang, Yi Gong, Qi Zhu, Miaoran Xu, Kai Yang, José V Anguita, Wei Zhang, S Ravi P Silva, Yanfeng Gao, Zongtao Zhang","doi":"10.1002/advs.202507385","DOIUrl":"https://doi.org/10.1002/advs.202507385","url":null,"abstract":"Sulfurized polyacrylonitrile (SPAN) has emerged as a promising cathode material for high-energy-density lithium‒sulfur (Li‒S) batteries due to its ability to confine sulfur and suppress polysulfide shuttling. However, conventional SPAN suffers from sluggish conversion kinetics and limited sulfur utilization, especially at high sulfur loadings. In this work, reconfigurable indium‒sulfur (In-S) coordination into SPAN to dynamically regulate sulfur bonding states is introduced. The non-crystalline In-S network reversibly anchors and releases sulfur during cycling, accelerating redox reactions while suppressing phase segregation. Structural analysis reveals atomically dispersed In-S coordination without crystalline inactive phases, achieving an active material content of 47.4 wt.% with only 1.18 wt.% indium addition (≈23% higher than conventional SPAN). Optimized In5-SPAN cathodes deliver a high specific capacity of 1048 mAh·g-1 at 0.5 A g-1 under practical conditions of high SPAN mass loading (8.7 mg cm-2) and lean electrolyte (E/SPAN = 4.1). This performance surpasses state-of-the-art SPAN-based cathodes under comparable lean-electrolyte and high-loading conditions. These findings illustrate a novel reconfigurable metal‒sulfur coordination strategy for next-generation Li‒S batteries with both high-energy-density and long cycle life.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07385"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertical GaN-On-GaN Micro-LEDs for Near-Eye Displays. 用于近眼显示的垂直GaN-On-GaN微型led。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202506784

Zichun Li, Yibo Liu, Haonan Jiang, Feng Feng, Jingyang Zhang, Shan Huang, Fion Yeung, Manchun Tseng, Man Wong, Hoi Sing Kwok, Zhaojun Liu

{"title":"Vertical GaN-On-GaN Micro-LEDs for Near-Eye Displays.","authors":"Zichun Li, Yibo Liu, Haonan Jiang, Feng Feng, Jingyang Zhang, Shan Huang, Fion Yeung, Manchun Tseng, Man Wong, Hoi Sing Kwok, Zhaojun Liu","doi":"10.1002/advs.202506784","DOIUrl":"https://doi.org/10.1002/advs.202506784","url":null,"abstract":"In various micro-light-emitting diode (micro-LED) display products, near-eye applications such as AR (augmented reality) and VR (virtual reality) are gaining popularity, driving consumer demand for higher brightness, resolution, and compact size. To address more advanced demands, GaN-on-GaN homoepitaxial micro-LEDs are notable for their low defect density, excellent thermal management, high efficiency, etc. Additionally, the conductivity of the GaN substrate enables the efficient integration of vertical micro-LEDs, further enhancing performance for near-eye displays. In this work, GaN-on-GaN homoepitaxial platforms to fabricate low-defect-density micro-LEDs are leveraged with superior electrical properties, addressing the limitations of conventional heterogeneous substrates. By replacing traditional ICP (Inductively coupled plasma) mesa etching with fluorine ion implantation for pixel isolation, this study achieves significant reductions in series resistance and enhances optical performance, characterized by sharper pixel edges and a narrowed full width at half maximum (FWHM). Furthermore, the implementation of vertical micro-LED architectures enables a compact device footprint, facilitating ultra-dense integration for near-eye systems. To evaluate performance under practical operating conditions, the effective external quantum efficiency (EQEeffective) is introduced. The ion-implanted vertical structures demonstrate a substantial improvement in EQEeffective over traditional ICP-etched devices, underscoring their potential for high-brightness applications. This work advances high-resolution, energy-efficient micro-LED technologies, offering a scalable pathway for next-generation AR/VR displays.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06784"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chinese Nian Gao Inspired Textured Janus Hydrogel for Body Signal Sensing and Human Machine Interaction. 基于人体信号传感和人机交互的纹理Janus水凝胶。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202509573

Haiyu Li, Hui Zhang, Xinxin Liu, Jing Jie, Ming Yin, Jie Du

{"title":"Chinese Nian Gao Inspired Textured Janus Hydrogel for Body Signal Sensing and Human Machine Interaction.","authors":"Haiyu Li, Hui Zhang, Xinxin Liu, Jing Jie, Ming Yin, Jie Du","doi":"10.1002/advs.202509573","DOIUrl":"https://doi.org/10.1002/advs.202509573","url":null,"abstract":"Inspired by Chinese Nian Gao, a traditional food in China, a skin-like bio-hydrogel with asymmetric Janus adhesion and textured structures on its surface is fabricated via a one-pot strategy and is evaluated as electronic skin for sensing and human-machine interaction. The e-skin is constructed through hydrogen bonding and metal-ligand coordination with favorable toughness and stretchability (tensile strength of 173 kPa, strain of 1593%). The bottom surface of the e-skin reached an adhesion strength of 66.7 kPa, and the upper surface shows no adhesion on different substrates, which ensures the stable signal collection on the bottom and avoids interference from incidental contact with clothing or external objects on the upper side. The skin-mimic textures are created in drying, which endows the hydrogel with visual authenticity comparable to biological skin; consequently, it can be used for human scar coverage and skin encapsulation of humanoid robots. The e-skin has an outstanding biocompatibility as well as a high self-healing efficiency of 93.5% and it is developed and demonstrated for multipurpose real-time applications. Furthermore, it accurately identifies hand gestures to control an assistive robotic arm in real-time based on EMG and EEG signals, highlighting its potential in next-generation aesthetic and functional wearable electronics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09573"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Ligand Strategy in Rh-Catalyzed Sequential Hydrofunctionalization of Valylene. 双配体策略在铑催化的顺序加氢功能化中的应用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202511331

Yong-Kang Mei, Su-Yang Xu, Zhi-Hui Wang, Ding-Wei Ji, Qing-An Chen

{"title":"Dual-Ligand Strategy in Rh-Catalyzed Sequential Hydrofunctionalization of Valylene.","authors":"Yong-Kang Mei, Su-Yang Xu, Zhi-Hui Wang, Ding-Wei Ji, Qing-An Chen","doi":"10.1002/advs.202511331","DOIUrl":"https://doi.org/10.1002/advs.202511331","url":null,"abstract":"Controlling regio- and chemo-selectivity in transition-metal-catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge. In this study, a dual-ligand strategy is introduced to orthogonally regulate both nucleophilic and electrophilic sites in the rhodium-catalyzed sequential hydrofunctionalization of valylene. Leveraging the synergistic effects of bidentate and monodentate phosphine ligands, cyclic prenylation of 4-hydroxycoumarins is achieved with outstanding regio- and chemo-selectivity under basic conditions. Conversely, structurally reversed prenylation is selectively obtained using a dppb (1,4-bis(diphenylphosphino)butane)/DME (1,2-dimethoxyethane) ligand combination under acidic conditions. This efficient and versatile protocol is also applicable to pyrazol-5-one substrates, yielding high-value dihydropyrano[2,3-c]pyrazole analogs. Mechanistic studies suggest that the cyclic prenylation proceeds via C3- or O-propargylation, followed by Rh- or acid-promoted intermolecular annulation. It is hoped that this strategy will provide valuable insights for addressing selectivity challenges in transition-metal catalysis and inspire further developments in this field.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e11331"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Strategy for Cluster-Based Covalent Organic Framework: Thermally Induced Covalent Crosslinking of Highly Stable Copper Clusters. 基于团簇的共价有机骨架的新策略：高稳定铜团簇的热诱导共价交联。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202507510

Jian-Peng Dong, Yue Xu, Ling Yao, Le Wang, Gang Li, Rui Wang, Shuang-Quan Zang

{"title":"New Strategy for Cluster-Based Covalent Organic Framework: Thermally Induced Covalent Crosslinking of Highly Stable Copper Clusters.","authors":"Jian-Peng Dong, Yue Xu, Ling Yao, Le Wang, Gang Li, Rui Wang, Shuang-Quan Zang","doi":"10.1002/advs.202507510","DOIUrl":"https://doi.org/10.1002/advs.202507510","url":null,"abstract":"Copper nanoclusters (Cu NCs) have emerged as a remarkable class of CO2 reduction reaction catalysts that are distinguished by their unparalleled reactivity, but effectively modulating the transport pathway of charge carriers between Cu NCs by feasible chemical means is still challenging. Herein, a thermally induced covalent crosslinking strategy is proposed to modulate the fast electron transport pathway formed between clusters. A copper-sulfur-nitrogen cluster [Cu4(SN)4] (denoted Cu4SN) is first synthesized; subsequently, the SN ligands in Cu4SN are coupled covalently via a thermally induced covalent crosslinking strategy to yield CC-Cu4SN, which exhibits enhanced conductivity and photocarrier transport. As expected, CC-Cu4SN shows a high photocatalytic CO production rate of 29.98 µmol g-1 h-1 with ≈99.5% selectivity in CO2 reduction with H2O as sacrificial agents, which is more than 10 times superior to that observed with Cu4SN. Systematic experiments and density functional theory calculations reveal that the covalent crosslinks between clusters accelerate the dynamic transfer of photoexcited charge carriers, increase the light utilization ability, favor CO2 adsorption and *COOH generation, thereby accounting for the increased CO2 photoreduction activity. This work presents a novel thermally induced internal covalent crosslinking strategy for synthesizing novel cluster-based covalent polymers with enhanced stability and catalytic activity.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07510"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Conversion Efficiency in Intrinsic High Power-Density Mg₂Sn-GeTe Thermoelectric Generator. 本征高功率密度Mg2Sn-GeTe热电发生器的高转换效率。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202506997

Xinzhi Wu, Longquan Wang, Airan Li, Gang Wu, Zhao Hu, Fei Frank Yun, Takao Mori

{"title":"High Conversion Efficiency in Intrinsic High Power-Density Mg2Sn-GeTe Thermoelectric Generator.","authors":"Xinzhi Wu, Longquan Wang, Airan Li, Gang Wu, Zhao Hu, Fei Frank Yun, Takao Mori","doi":"10.1002/advs.202506997","DOIUrl":"https://doi.org/10.1002/advs.202506997","url":null,"abstract":"Thermoelectric generators (TEGs) offer a sustainable solution for thermal energy harvesting, where maximizing energy output necessitates achieving both high power density and high conversion efficiency. However, TEGs with intrinsically high power density by employing high power factor materials often face efficiency limitations due to their usually high thermal conductivity. Here, intrinsically high power density TEGs based on Mg2Sn-GeTe for the first time is presented, simultaneously delivering a remarkable conversion efficiency of 9% under a temperature gradient of 418 K, thereby setting a new benchmark in the field. This exceptional performance is attributed to the significant balance between the moderating carrier and phonon transport in Mg2Sn, enabled by a stepwise aliovalent Sb and Bi solid solution, without over-compromising its outstanding power factor. Consequently, a high thermoelectric figure of merit of 1.4 is achieved in Mg2Sn0.8(Sb0.5Bi0.5)0.2. The high-performance Mg2Sn-GeTe TEGs introduced here represent a significant advancement in thermoelectric technology, offering an innovative and efficient solution for off-grid energy supply in waste-heat-rich environments.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06997"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled Moiré Superlattices of Ti₃C₂T_x MXene for Future Twistronic Applications. 自组装Ti3C2Tx MXene超晶格用于未来的涡旋应用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202504394

Kuanysh Zhussupbekov, Andrea Cabero Del Hierro, Samuel Berman, Dahnan Spurling, Ainur Zhussupbekova, Stefano Ippolito, David D O'Regan, Igor Shvets, Yury Gogotsi, Valeria Nicolosi

{"title":"Self-Assembled Moiré Superlattices of Ti3C2Tx MXene for Future Twistronic Applications.","authors":"Kuanysh Zhussupbekov, Andrea Cabero Del Hierro, Samuel Berman, Dahnan Spurling, Ainur Zhussupbekova, Stefano Ippolito, David D O'Regan, Igor Shvets, Yury Gogotsi, Valeria Nicolosi","doi":"10.1002/advs.202504394","DOIUrl":"https://doi.org/10.1002/advs.202504394","url":null,"abstract":"Nanoscale periodic Moiré superlattices based on 2D heterostructures offer an opportunity to unveil and exploit electronic and quantum properties that are not present in single-layer 2D and/or 3D bulk counterparts. However, a detailed understanding of the Moiré superlattices and their resulting electronic structure at the atomic scale is currently lacking in many systems, such as the fastest-growing family of 2D materials, MXenes. This is crucial for gaining fundamental knowledge and mastery over quantum phenomena in these materials. This study thoroughly examines and compares the self-assembled Moiré superlattices of the most prominent MXene, Ti3C2Tx, by combining experimental scanning tunneling microscopy and spectroscopy with density functional theory calculations. Three distinct self-assembled Moiré patterns with a periodicity of 2.52, 2.39, and 1.25 nm are investigated. Experimental and theoretical data reveal that the Moiré superlattice with a periodicity of 1.25 nm exhibits a spatial modulation of the density of states in the conduction band due to electronic interlayer coupling effects. The findings unveil MXene Moiré superlattices at the atomic level and pave the way to a new research field in MXetronics and twistronics with great potential for quantum devices and related applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04394"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Spectral Tunability by Sub-10 nm Nanogaps in Graphene-Metal Hybrid Metasurfaces. 石墨烯-金属杂化超表面的亚10nm纳米间隙增强光谱可调性。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202506898

Fei Han, Zaoyang Lin, Kacper Pilarczyk, Hongwei Tang, Guy A E Vandenbosch, Joris Van de Vondel, Xuezhi Zheng, Niels Verellen, Ewald Janssens

{"title":"Enhanced Spectral Tunability by Sub-10 nm Nanogaps in Graphene-Metal Hybrid Metasurfaces.","authors":"Fei Han, Zaoyang Lin, Kacper Pilarczyk, Hongwei Tang, Guy A E Vandenbosch, Joris Van de Vondel, Xuezhi Zheng, Niels Verellen, Ewald Janssens","doi":"10.1002/advs.202506898","DOIUrl":"https://doi.org/10.1002/advs.202506898","url":null,"abstract":"Electrically tunable graphene-metal metasurfaces have emerged as a promising platform for precise control of free-space light propagation. However, their resonance tuning range is limited by fabrication constraints, particularly by the achievable gap size between coupled antennas, which is the parameter that influences the device's performance most. In this work, this challenge is addressed by introducing a novel fabrication approach that combines traditional e-beam lithography with physical vapor deposition of an additional thin metal layer and subsequent ion milling. Incorporating an Al2O3 etch-stop layer allows to overcome the ≈20 nm gap size limitation of conventional methods. Using this approach sub-10 nm gaps can be fabricated reliably and the tuning range of metasurfaces operating in the mid-infrared is increased from 0.50 to 0.77 µm, together with an enhancement in the maximum modulation depth from 45% to 59%. The better performance is attributed to stronger field enhancement in the reduced nanogap. This work is a critical step toward widely tunable mid-infrared metasurfaces, with potential applications in spatial light modulators, surface-enhanced Raman spectroscopy, and quantum photonics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06898"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC-Mediated Mitophagy to Exert Anti-Tumor Activities in ALK-Positive Anaplastic Large Cell Lymphoma. 在alk阳性间变性大细胞淋巴瘤中，PTPN2抑制破坏线粒体更新并阻断tfrc介导的线粒体自噬发挥抗肿瘤活性

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-07-30 DOI: 10.1002/advs.202414282

Wei-Ting Wang, Zi-Wen Duan, Tong-Yao Xing, Wei Hua, Kai-Xing Du, Chun-Yu Shang, Yi-Fan Wu, Li Wang, Jian-Yong Li, Rui Gao, Jin-Hua Liang, Wei Xu

{"title":"PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC-Mediated Mitophagy to Exert Anti-Tumor Activities in ALK-Positive Anaplastic Large Cell Lymphoma.","authors":"Wei-Ting Wang, Zi-Wen Duan, Tong-Yao Xing, Wei Hua, Kai-Xing Du, Chun-Yu Shang, Yi-Fan Wu, Li Wang, Jian-Yong Li, Rui Gao, Jin-Hua Liang, Wei Xu","doi":"10.1002/advs.202414282","DOIUrl":"https://doi.org/10.1002/advs.202414282","url":null,"abstract":"Anaplastic large cell lymphoma (ALCL) is a heterogeneous subtype of T-cell lymphoma usually driven by genetic alterations affecting the anaplastic lymphoma kinase (ALK) gene. Despite the relatively favorable prognosis of ALK-positive (ALK+) ALCL, approximately 30-40% of patients experience relapses or disease progression. This work identifies protein tyrosine phosphatase PTPN2 as a critical gene essential for the growth and survival of ALK+ ALCL by CRISPR/Cas9 editing. PTPN2 depletion can significantly suppress tumor cell proliferation, induce apoptosis, and provoke cell cycle arrest. Mechanistically, PTPN2 negatively regulates transferrin receptor (TFRC) expression to promote mitochondrial renewal via PTEN induced kinase 1 (PINK1)-PRKN (parkin RBR E3 ubiquitin protein ligase)-mediated mitophagy. The process functions independently of ferroptosis. Interestingly, TFRC is directly regulated by the transcription factor hypoxia-inducible factor 1 alpha (HIF1A) in its promoter. Notably, an orally bioavailable potent PTPN2/N1 active-site inhibitor ABBV-CLS-484 (AC484) demonstrates significant therapeutic potential against ALK+ ALCL by disturbing mitochondrial renewal and blocking TFRC-mediated PINK1-PRKN-dependent mitophagy to exert anti-tumor activities, providing critical insights into the selection of targeted treatment strategies for ALK+ ALCL patients and a strong rationale for advancing AC484 into clinical trials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e14282"},"PeriodicalIF":14.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0