Advanced Science最新文献_第2页

Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7-driven Small Cell Lung Cancer (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570096

Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang

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Pericytes Promote More Vascularization than Stromal Cells via an Interleukin-6-Dependent Mechanism in Microfluidic Chips (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570093

Julian Gonzalez-Rubio, Hannah Kubiza, Yong Xu, Hiltrud Koenigs-Werner, Mona Sophie Schmitz, Michaela Schedel, Christian Apel, Stefan Jockenhoevel, Christian G. Cornelissen, Anja Lena Thiebes

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Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression (Adv. Sci. 14/2025) 治疗性黑磷纳米片可激发中性粒细胞反应，增强肿瘤抑制能力（科学进展 14/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570100

Jing Wang, Weiqiang Yu, Hui Shen, Yanxiang Sang, Hongjie Zhang, Benyan Zheng, Xue Peng, Yuan Hu, Xiaopeng Ma, Zhenye Yang, Fazhi Yu

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Rational Design of Natural Xanthones Against Gram-negative Bacteria (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570099

Xiaojia Liu, Meirong Song, Ying Liu, Shuyu Yang, Shang Chen, Jijun Kang, Jianzhong Shen, Kui Zhu

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Improved Efficacy of Triple-Negative Breast Cancer Immunotherapy via Hydrogel-Based Co-Delivery of CAR-T Cells and Mitophagy Agonist (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570094

Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao

{"title":"Improved Efficacy of Triple-Negative Breast Cancer Immunotherapy via Hydrogel-Based Co-Delivery of CAR-T Cells and Mitophagy Agonist (Adv. Sci. 14/2025)","authors":"Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao","doi":"10.1002/advs.202570094","DOIUrl":"https://doi.org/10.1002/advs.202570094","url":null,"abstract":"CAR-T-Cell TherapyIn article number 2409835 by , Beichen Liu, Yuan Gao, Huadong Zhao, and co-workers, injection hydrogels are engineered for the controlled co-delivery of CAR-T cells and BC1618 that improves the treatment of TNBC. On the cover: The ocean currents represent the delivery medium of CAR-T cells, which is the hydrogel. The schools of small fish swimming around symbolize BC1618, an agonist that can enhance the function of CAR-T cells. The shark represents tumor cells, while the narwhal represents CAR-T cells with enhanced attack power after being delivered by the hydrogel. The dolphins in the background represent regular CAR-T cells, which have relatively weaker attack power.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 14","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570098

Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo

引用次数: 0

Issue Information: (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570097

引用次数: 0

Electrically-Shielded Coil-Enabled Battery-Free Wireless Sensing for Underwater Environmental Monitoring (Adv. Sci. 14/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-10 DOI: 10.1002/advs.202570095

Ke Wu, Xia Zhu, Stephan W. Anderson, Xin Zhang

引用次数: 0

Programmable Metamaterials with Perforated Shell Group Supporting Versatile Information Processing.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-09 DOI: 10.1002/advs.202417784

Xiaoyuan Ma, Ziran Wang, Weipeng Zhang, Peng Yan

{"title":"Programmable Metamaterials with Perforated Shell Group Supporting Versatile Information Processing.","authors":"Xiaoyuan Ma, Ziran Wang, Weipeng Zhang, Peng Yan","doi":"10.1002/advs.202417784","DOIUrl":"https://doi.org/10.1002/advs.202417784","url":null,"abstract":"Mechanical metamaterials have emerged as promising tools for enabling mechanical intelligence in soft machines through interaction with the external environment. Note that most representative results in the literature focused on certain features of information processing with the designs of novel metamaterials. It remains challenging to design metamaterials with more integrated information processing capabilities toward comprehensive intelligence. In this work, a novel approach employing programmable multi-stability of perforated shells (PS) with staggered trapezoidal voids is proposed to develop transformable, information-processing metamaterials with high-density information. Multi-layer information storage, encoding, decoding, and reading are achieved by designing and arranging different types of PSs under mechanical compression or magnetic actuation. In addition, various application-oriented functionalities, such as information encryption, mechanical computing, wave amplification, and pressure transmission, are also demonstrated by taking advantage of the stable memory and tunable stiffness distributions of metamaterials. The proposed design strategy paves the way for multifunctional, miniaturized, and scalable information mechanical metamaterials, with significant potential for soft-material-based intelligent devices.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2417784"},"PeriodicalIF":14.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-09 DOI: 10.1002/advs.202503192

Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang

{"title":"Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis.","authors":"Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang","doi":"10.1002/advs.202503192","DOIUrl":"https://doi.org/10.1002/advs.202503192","url":null,"abstract":"Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint kinase (WEE1), promoting inflammation in atherosclerosis is identified. Kinase enrichment analysis and experimental evidences reveal macrophage WEE1 phosphorylation at S642 in human and mouse atherosclerotic tissues. RNA-seq analysis, combined with experiment studies using mutant WEE1 plasmids, shows that WEE1 phosphorylation, rather than WEE1 expression, mediated oxLDL-induced inflammation in macrophages. Macrophage-specific deletion of WEE1 or pharmacological inhibition of WEE1 kinase activity attenuates atherosclerosis by reducing inflammation in mice. Mechanistically, RNA-seq and co-immunoprecipitation followed by proteomics analysis are used to explore the mechanism and substrate of WEE1. p-WEE1 promoted inflammatory response through activating NF-κB shown and further revealed that WEE1 can directly bind to the p65 subunit. It is confirmed that p-WEE1 directly interacts with the RHD domain of p65 and phosphorylates p65 at S536, thereby facilitating subsequent NF-κB activation and inflammatory response in macrophages. The findings demonstrate that macrophage WEE1 drives NF-κB activation and atherosclerosis by directly phosphorylating p65 at S536. This study identifies WEE1 as a new upstream kinase of p65 and a potential therapeutic target for atherosclerosis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2503192"},"PeriodicalIF":14.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0