Advanced Science最新文献_第2页

Correction to "Wheel-Running Exercise Alleviates Anxiety-Like Behavior via Down-Regulating S-Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats".

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202415925

引用次数: 0

From Radioactive Effluent to Drinking Water: Efficient Removal of Trace ⁹⁹TcO₄ ^-/ReO₄ ^- by Cationic Porous Aromatic Framework. 从放射性废水到饮用水：阳离子多孔芳香族框架高效去除痕量 99TcO4 -/ReO4-。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202414604

Long-Sheng Pang, Xiangjun Liao, Chao-Yue Zhao, Cheng-Peng Li, Zhong Liu, Shengqian Ma

{"title":"From Radioactive Effluent to Drinking Water: Efficient Removal of Trace 99TcO4 -/ReO4 - by Cationic Porous Aromatic Framework.","authors":"Long-Sheng Pang, Xiangjun Liao, Chao-Yue Zhao, Cheng-Peng Li, Zhong Liu, Shengqian Ma","doi":"10.1002/advs.202414604","DOIUrl":"https://doi.org/10.1002/advs.202414604","url":null,"abstract":"Efficient removal of 99TcO4 - from radioactive effluents while recovering drinking water remains a challenge. Herein, an excellent ReO4 - (a nonradioactive surrogate of 99TcO4 -) scavenger is presented through covalently bonding imidazolium poly(ionic liquids) polymers with an ionic porous aromatic framework (iPAF), namely iPAF-P67, following an adsorption-site density-addition strategy. It shows rapid sorption kinetics, high uptake capacity, and exceptional selectivity toward ReO4 -. Notably, the residual concentration of TcO4 -/ReO4 - in the radioactive wastewater after iPAF-P67 treatment is as low as 0.046 ppb, fully meeting the drinking water standards of World Health Organization (WHO, 0.159 ppb) and United States Environmental Protection Agency (U.S. EPA, 0.053 ppb). Density functional theory (DFT) calculations show that the imidazolium groups in iPAF-P67 provide stronger electrostatic interactions and higher binding energies between iPAF-P67 and TcO4 - anions, leading to its superior adsorption performance. Furthermore, the scale-up synthesized iPAF-P67 materials are shaped with polyethersulfone (PES) to fabricate PAF-P67/PES beads and nanofibers via phase inversion method and electrospinning technique, respectively. Both composites demonstrate outstanding ultra-purification abilities toward ReO4 - to meet the WHO criteria even after multiple dynamic adsorption/desorption cycles. This work develops a design strategy for adsorbents applicable in the sequestration of low-concentration radioactive pollutants.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414604"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultramicroporous Tröger's Base Framework Membranes With Ionized Sub-nanochannels for Efficient Acid/Alkali Recovery.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202414280

Haopan Sun, Ning Gan, Yuqing Lin, Baolong Wu, Yulong Qiu, Jingwen Su, Ziding Zhou, Fengyin Zou, Jianguo Yu, Hideto Matsuyama

{"title":"Ultramicroporous Tröger's Base Framework Membranes With Ionized Sub-nanochannels for Efficient Acid/Alkali Recovery.","authors":"Haopan Sun, Ning Gan, Yuqing Lin, Baolong Wu, Yulong Qiu, Jingwen Su, Ziding Zhou, Fengyin Zou, Jianguo Yu, Hideto Matsuyama","doi":"10.1002/advs.202414280","DOIUrl":"https://doi.org/10.1002/advs.202414280","url":null,"abstract":"Membrane technology holds significant potential for the recovery of acids and alkalis from industrial wastewater systems, with ion exchange membranes (IEMs) playing a crucial role in these applications. However, conventional IEMs are limited to separating only monovalent cations or anions, presenting a significant challenge in achieving concomitant H⁺/OH⁻ permselectivity for simultaneous acid and alkali recovery. To address this issue, the charged microporous polymer framework membranes are developed, featuring rigid Tröger's Base network chains constructed through a facile sol-gel process. The intrinsic ultramicropore confinement and quaternary ammonium-charged functional groups provide ultrahigh size-sieving capability and enhanced Donnan exclusion for H⁺/OH⁻ selectivity; meanwhile, the internal protoplasmic channels of the polymer frameworks serve as highways for rapid ion transfer. The resulting membrane achieves high H⁺/Fe2⁺ and OH⁻/WO₄2⁻ selectivities of 694.4 and 181.0, respectively, for concurrent acid and alkali separation in diffusion dialysis and electrodialysis processes over extended operational periods (exceeding 1600 and 600 h, respectively), while maintaining remarkable transport rates. These results outperform most literature-reported and nearly all commercially available membranes. This study validates the novel applicability of polymer framework materials with ionized angstrom-scale channels and versatile functionalities in high-performance IEMs for acid/alkali resource recovery.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414280"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electron-Rich Heptacyclic S,N Heteroacene Enabling C-Shaped A-D-A-type Electron Acceptors With Photoelectric Response beyond 1000 Nm for Highly Sensitive Near-Infrared Photodetectors.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202413045

Kuo-Hsiu Huang, Bing-Huang Jiang, Han-Cheng Lu, Yung-Jing Xue, Chia-Fang Lu, Yung-Yung Chang, Ching-Li Huang, Su-Ying Chien, Chih-Ping Chen, Yen-Ju Cheng

{"title":"Electron-Rich Heptacyclic S,N Heteroacene Enabling C-Shaped A-D-A-type Electron Acceptors With Photoelectric Response beyond 1000 Nm for Highly Sensitive Near-Infrared Photodetectors.","authors":"Kuo-Hsiu Huang, Bing-Huang Jiang, Han-Cheng Lu, Yung-Jing Xue, Chia-Fang Lu, Yung-Yung Chang, Ching-Li Huang, Su-Ying Chien, Chih-Ping Chen, Yen-Ju Cheng","doi":"10.1002/advs.202413045","DOIUrl":"https://doi.org/10.1002/advs.202413045","url":null,"abstract":"A highly electron-rich S,N heteroacene building block is developed and condensed with FIC and Cl-IC acceptors to furnish CT-F and CT-Cl, which exhibit near-infrared (NIR) absorption beyond 1000 nm. The C-shaped CT-F and CT-Cl self-assemble into a highly ordered 3D intermolecular packing network via multiple π-π interactions in the single crystal structures. The CT-F-based organic photovoltaic (OPV) achieved an impressive efficiency of 14.30% with a broad external quantum efficiency response extending from the UV-vis to the NIR (300-1050 nm) regions, outperforming most binary OPVs employing NIR A-D-A-type acceptors. CT-Cl possesses a higher surface energy than CT-F, promoting vertical phase segregation and resulting in its preferential accumulation near the bottom interface of the blend. This arrangement, combined with the lower HOMO energy level of CT-Cl, effectively reduces undesired hole and electron injection under reverse voltage. The PM6:CT-Cl-based organic photodetectors (OPDs) devices achieved an ultra-high shot-noise-limited specific detectivity (Dsh*) values exceeding 1014 Jones in the NIR region from 620 to 1000 nm, reaching an unprecedentedly high value of 1.3 × 1014 Jones at 950 nm. When utilizing a 780 nm light source, the PM6:CT-Cl-based OPDs show record-high rise/fall times of 0.33/0.11 µs and an exceptional cut-off frequency (f-3dB) of 590 kHz at -1 V.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413045"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotherapy for Neural Retinal Regeneration.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202409854

Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen-Bin Wei

{"title":"Nanotherapy for Neural Retinal Regeneration.","authors":"Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen-Bin Wei","doi":"10.1002/advs.202409854","DOIUrl":"https://doi.org/10.1002/advs.202409854","url":null,"abstract":"Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by the protective inner and outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential in addressing the issue of drug delivery to the eye. Moreover, nanotechnology-based therapeutics can have profound clinical impacts on retinopathy, particularly retinal regeneration, thereby improving patient outcomes. Continuous advancements in nanotechnology are being applied to regenerate lost or damaged eye tissues and to treat vision loss and blindness caused by various retinal degenerative diseases. These approaches can be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, and other essential substances; ii) nanoscaffolds for providing biocompatible support; and iii) nanocomposites for enhancing the functionality of primary or stem cells. The aim of this comprehensive review is to present the current understanding of nanotechnology-based therapeutics for retinal regeneration, with a focus on the perspective functions of nanomaterials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409854"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanoluminescence from Organic-Inorganic Metal Halide Perovskite Derivative.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202414588

Hongyuan Zhao, Xinyu Yang, Yunfei Bai, Qichao Meng, Ziying Wen, Haibo Sun, Qilin Wei, Dan Huang, William W Yu, Feng Liu

引用次数: 0

Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202412349

Min Chen, Shuwen Fan, Jiabao Mao, Linhan Huang, Nafisa Tursun, Chen Zhang, Wen Li, Shufeng Li

{"title":"Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.","authors":"Min Chen, Shuwen Fan, Jiabao Mao, Linhan Huang, Nafisa Tursun, Chen Zhang, Wen Li, Shufeng Li","doi":"10.1002/advs.202412349","DOIUrl":"https://doi.org/10.1002/advs.202412349","url":null,"abstract":"Tinnitus, a widespread condition affecting numerous individuals worldwide, remains a significant challenge due to limited effective therapeutic interventions. Intriguingly, patients using cochlear implants (CIs) have reported significant relief from tinnitus symptoms, although the underlying mechanisms remain unclear and intracochlear implantation risks cochlear damage and hearing loss. This study demonstrates that targeted intracochlear electrical stimulation (ES) in guinea pigs with noise-induced hearing loss reversed tinnitus-related maladaptive plasticity in the cochlear nucleus (CN), characterized by reduced auditory innervation, increased somatosensory innervation, and diminished inhibitory neural networks. Additionally, a customized extracochlear ES delivered by a newly designed extracochlear electrode array to guinea pigs with salicylate-induced tinnitus also reversed the aforementioned maladaptive plasticity and alleviated tinnitus without causing additional cochlear damage or hearing loss. These findings suggest that CI-delivered ES may alleviate tinnitus by reversing maladaptive CN plasticity. Additionally, the extracochlear ES strategy offers a promising tinnitus treatment with minimal risk to hearing.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412349"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202413296

Yao-Yuan Zhang, Song-Tao Chen, Gang Chen, Le Zhou, Guo-Liang Zhou, Xin-Yuan Yu, Long Yuan, Wei-Qian Deng, Zhen-Bo Wang, Jing Li, Yi-Fu Tu, Da-Wei Zhang, Yuan Li, Abdul Sammad, Xiao Zhu, Kai Yin

{"title":"The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus.","authors":"Yao-Yuan Zhang, Song-Tao Chen, Gang Chen, Le Zhou, Guo-Liang Zhou, Xin-Yuan Yu, Long Yuan, Wei-Qian Deng, Zhen-Bo Wang, Jing Li, Yi-Fu Tu, Da-Wei Zhang, Yuan Li, Abdul Sammad, Xiao Zhu, Kai Yin","doi":"10.1002/advs.202413296","DOIUrl":"https://doi.org/10.1002/advs.202413296","url":null,"abstract":"Large-scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia-Shigella in patients with T2DM-related-ASCVD, which correlates with their atherosclerotic stenosis is reported. Overexpression of T3SS via Citrobacter rodentium (CR) infection in Apoe-/- T2DM mice exacerbated atherosclerotic lesion formation and increased gut permeability. Non-targeted metabolomic and proteomic analysis of mouse serum showed that T3SS caused abnormal glycerophospholipid metabolism in mice. Proteomics, RNA sequencing, and functional analyses showed that T3SS induced ferroptosis in intestinal epithelial cells, partly due to increased expression of ferritin heavy chains (FTH1). This findings first demonstrated that T3SS increases ferroptosis in intestinal epithelial cells, via disrupting the intestinal barrier and upregulation of phosphatidylcholine, thereby exacerbating T2DM-related ASCVD.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413296"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mannose Promotes β-Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202409105

Chensi Liang, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Zhenlei Chen, Dan Can, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang

{"title":"Mannose Promotes β-Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease.","authors":"Chensi Liang, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Zhenlei Chen, Dan Can, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang","doi":"10.1002/advs.202409105","DOIUrl":"https://doi.org/10.1002/advs.202409105","url":null,"abstract":"Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and serum of AD mice, as well as in the serum of AD patients. AD mice are given mannose by intra-cerebroventricular injection (ICV) or in drinking water to investigate the effects of mannose on cognition and AD pathological progression. Chronic mannose overload increases β-amyloid (Aβ) burdens and exacerbates cognitive impairments, which are reversed by a mannose-free diet or mannose transporter antagonists. Mechanistically, single-cell RNA sequencing and metabolomics suggested that mannose-mediated N-glycosylation of BACE1 and Nicastrin enhances their protein stability, promoting Aβ production. Additionally, reduced mannose intake decreased BACE1 and Nicastrin stability, ultimately lowering Aβ production and mitigating AD pathology. this results highlight that high-dose mannose consumption may exacerbate AD pathogenesis. Restricting dietary mannose may have therapeutic benefits.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409105"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmon-Driven Gold Nanopillar Multiarrayed Gene Amplification Methodology for the High-Throughput Discrimination of Pathogens.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-14 DOI: 10.1002/advs.202411849

Sung Eun Seo, Kyung Ho Kim, Seo Jin Kim, Kyong-Cheol Ko, Woo-Keun Kim, Kyoung G Lee, Oh Seok Kwon

{"title":"Plasmon-Driven Gold Nanopillar Multiarrayed Gene Amplification Methodology for the High-Throughput Discrimination of Pathogens.","authors":"Sung Eun Seo, Kyung Ho Kim, Seo Jin Kim, Kyong-Cheol Ko, Woo-Keun Kim, Kyoung G Lee, Oh Seok Kwon","doi":"10.1002/advs.202411849","DOIUrl":"https://doi.org/10.1002/advs.202411849","url":null,"abstract":"Molecular diagnosis limitations, including complex treatment processes, low cost-effectiveness, and operator-dependent low reproducibility, interrupt the timely prevention of disease spread and the development of medical devices for home and outdoor uses. A newly fabricated gold nanopillar array-based film is presented for superior photothermal energy conversion. Magnifying the metal film surface-to-volume ratio increases the photothermal energy conversion efficiency, resulting in a swift reduction in the gene amplification reaction time. Plasmonic energy-based ultrafast gene amplification and facile confirmation methodology offer a rapid disease discrimination platform for high-throughput multiplexed diagnosis. The superior performance of the gold nanopillar arrayed film is demonstrated by measuring the amount of pathogen (Vibrio cholerae) with a sensitivity of 101 cfu mL-1 in 5.5 min. The newly engineered gold nanopillar arrayed film can be utilized to diagnose universal pathogens to achieve an increasingly successful complete cure.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411849"},"PeriodicalIF":14.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0