Advanced Science最新文献_第2页

Symmetry-Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies 非平凡等离子体拓扑激发的对称强制选择规则。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 Epub Date: 2026-08-10 DOI: 10.1002/advs.77043

Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng-Wei Qiu, Xuezhi Zheng

{"title":"Symmetry-Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies","authors":"Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng-Wei Qiu, Xuezhi Zheng","doi":"10.1002/advs.77043","DOIUrl":"10.1002/advs.77043","url":null,"abstract":"Nontrivial nearfield topologies in nano-optics refer to nearfield configurations embedded within singularities or topological defects, providing an ideal platform to explore integrated optoelectronics and higher-dimensional topological physics. Exciting such field topologies relies on selection rules related to various conserved quantities. Unfortunately, existing algebraic rules focus primarily on scalar singularities in nano-optical (e.g., plasmonic) systems and largely neglect the vectorial nature of the fields. More critically, these rules remain phenomenological. Given the intrinsic link between conserved quantities and symmetries, here we establish a unified selection rule using group theory that govern the excitations of nontrivial field topologies across three photonic spin states in generic nanophotonic systems. This rule can act as building blocks for constructing selection rules for exciting and engineering higher-dimensional field topologies (embedded within vectorial singularities and quasiparticles). These rules are derived purely from symmetry arguments and are therefore rooted in first principles. The proposed rules further predict two novel physical effects in plasmonic systems: spin-orbit splitting of vortices and multidimensional nested vortices. Phase-resolved in-situ measurements of nested multidimensional plasmonic topologies well demonstrate our findings. Our group-theory-based approach can serve as a versatile framework for engineering symmetry- and singularity-related phenomena—like circular meron lattices and plasmonic quasicrystals—in diverse wave systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation-Induced Lung Injury by Targeting Ferroptosis 华仙配方纳米配方对铁下垂急性辐射肺损伤的保护作用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 Epub Date: 2026-08-29 DOI: 10.1002/advs.77472

Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen

{"title":"A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation-Induced Lung Injury by Targeting Ferroptosis","authors":"Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen","doi":"10.1002/advs.77472","DOIUrl":"10.1002/advs.77472","url":null,"abstract":"Acute radiation-induced lung injury (RILI) remains a major dose-limiting complication of thoracic radiotherapy with limited therapeutic options. Here, we develop an inhalable nanoformulation of the traditional Chinese medicine Huaxian Formula (NHXF) with favorable physicochemical stability and enhanced pulmonary delivery properties. In vitro and in vivo studies demonstrate that NHXF attenuates radiation-induced alveolar epithelial injury, accompanied by reductions in oxidative stress and apoptosis. NHXF also suppresses secondary inflammatory responses, as evidenced by decreased pro-inflammatory cytokine production and neutrophil infiltration, which may contribute to its protective effects against acute RILI. Importantly, NHXF displays a favorable safety profile throughout treatment. Transcriptomic analysis highlights ferroptosis-related pathways associated with NHXF-mediated protection. Our findings indicate that NHXF treatment is associated with the attenuation of ferroptosis-related alterations in iron homeostasis and lipid peroxidation. Pharmacological activation of ferroptosis significantly diminishes the protective effects of NHXF against radiation-induced injury, further supporting a functional contribution of ferroptosis modulation to NHXF-mediated protection, while acknowledging that additional direct mechanistic evidence is warranted to establish causal dependency. Collectively, these findings support NHXF as a potential inhalable nanotherapeutic for acute RILI and highlight pulmonary delivery of nanoformulated traditional Chinese medicine combined with ferroptosis modulation as a promising strategy for RILI management.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voltage-Reconfigurable Magneto-Ionic Nanolayers in Dot Arrays for Probabilistic, Materials-Engineered Security Primitives (Adv. Sci. 62/2026) 基于点阵列的电压可重构磁离子纳米层的概率性，材料工程安全基元（ad . science . 62/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 DOI: 10.1002/advs.78409

Irena Spasojevic, Federica Celegato, Alessandro Magni, Paola Tiberto, Jordi Sort

引用次数: 0

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population-Level Stochastic Bioelectrical Dynamics in Marine Diatoms 介孔PU/PEDOT:PSS电极揭示海洋硅藻种群水平的随机生物电动力学。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 Epub Date: 2026-09-05 DOI: 10.1002/advs.77341

David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis-Josselin Lavier-Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha

{"title":"Mesoporous PU/PEDOT:PSS Electrodes Reveal Population-Level Stochastic Bioelectrical Dynamics in Marine Diatoms","authors":"David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis-Josselin Lavier-Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha","doi":"10.1002/advs.77341","DOIUrl":"10.1002/advs.77341","url":null,"abstract":"Understanding how microbial populations generate and modulate electrical signals remains a major technical challenge because extracellular ionic processes are inherently weak, spatially distributed and stochastic. Here, we introduce a mesoporous ultra-low-impedance PEDOT:PSS electrode that exploits volumetric ionic-electronic coupling to probe stochastic electrochemical dynamics in axenic populations of the marine model diatom Phaeodactylum tricornutum. The three-dimensional porous architecture provides a large electrochemically accessible surface area with high capacitance and low impedance, enabling sensitive detection of non-equilibrium current fluctuations under applied bias. Applied bias systematically amplifies stochastic electrical fluctuations, while living diatoms significantly modify their amplitude and temporal statistics. Noise analysis reveals enhanced low-frequency fluctuations, increased power-law exponents and higher transient-event rates, indicating biologically driven perturbations of the local electrochemical environment. Pharmacological inhibition with tetraethylammonium suppresses spontaneous electrical activity, providing independent functional evidence that membrane-associated potassium-dependent processes contribute to the measured signals. Increasing diatom cell density further produces progressively larger spectral exponents and distinct changes in stochastic-event dynamics, demonstrating that these electrical signatures encode microbial population density. These findings establish stochastic electrochemical noise as a sensitive, label-free probe of microbial bioelectrochemical activity and a bioelectronic strategy for monitoring living microbial systems through their intrinsic non-equilibrium electrical fluctuations.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation-Induced Lung Injury by Targeting Ferroptosis (Adv. Sci. 62/2026) 华仙配方纳米制剂对急性放射性肺损伤的保护作用（科学进展，62/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 DOI: 10.1002/advs.78412

Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen

引用次数: 0

Issue Information: (Adv. Sci. 62/2026) 发行信息：（科学通报62/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 DOI: 10.1002/advs.78411

引用次数: 0

Targeting the NR1D1–IGF2BP2–V-ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis-Induced Immunosuppression (Adv. Sci. 62/2026) 利用杂交纳米囊泡靶向NR1D1-IGF2BP2-V-ATPase轴恢复巨噬细胞节律以逆转败血症诱导的免疫抑制（Adv. Sci. 62/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 DOI: 10.1002/advs.78408

Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang

引用次数: 0

Programmable Sequential 4D Actuation in Multistable Kirigami Metamaterials 多稳定基里伽米超材料的可编程顺序四维驱动。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 Epub Date: 2026-08-24 DOI: 10.1002/advs.77412

Eui-Hyun Kim, Minsung Kim, Hyunsik Yoon, Keun Park

{"title":"Programmable Sequential 4D Actuation in Multistable Kirigami Metamaterials","authors":"Eui-Hyun Kim, Minsung Kim, Hyunsik Yoon, Keun Park","doi":"10.1002/advs.77412","DOIUrl":"10.1002/advs.77412","url":null,"abstract":"Programmable shape transformation is essential for adaptive soft mechanisms operating in constrained or dynamic environments. This study presents a modular kirigami metamaterial platform that enables programmable multistability and sequential 4D actuation through thermally triggered recovery. Inspired by geometric motifs from traditional Korean Dancheong patterns, in which symmetry and motif stacking govern pattern formation, two kirigami unit cells with different slit configurations are designed to exhibit distinct bistable responses and directional auxetic behavior. Using dual-material additive manufacturing, each cell integrates thermally responsive and passive thermoplastics to achieve cold-programmed bistability and sequential 4D actuation. This approach is validated through three functional mechanisms: (i) multimodal bridging structures capable of both mechanically and thermally induced reconfigurations; (ii) multistable 4D grippers capable of inward and outward transformations; and (iii) a biomimetic underwater cleaning robot that autonomously collects and encloses floating debris through sequential thermal recovery. All functions are achieved without electronic or pneumatic actuators, relying entirely on mechanically encoded transformations and thermal activation. Furthermore, the use of thermoplastics provides higher stiffness than elastomer-based actuators, opening new opportunities for thermo-mechanically encoded actuation with improved mechanical robustness.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Landscape of Long Non-Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit 长链非编码rna的研究为梨果实的驯化和改良提供了新的思路。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 Epub Date: 2026-08-19 DOI: 10.1002/advs.77091

Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu

{"title":"The Landscape of Long Non-Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit","authors":"Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu","doi":"10.1002/advs.77091","DOIUrl":"10.1002/advs.77091","url":null,"abstract":"Long non-coding RNAs (lncRNAs) play essential roles in plant growth and development. However, their expression variability and contribution to phenotypic changes during the domestication of fruit crops remain unclear. Here, we generated approximately 3.5T of strand-specific RNA sequencing data from wild, landrace, and improved pear varieties and identified 12 422 lncRNAs that exhibited higher tissue specificity and lower sequence conservation than protein-coding genes. Roughly 74% of lncRNAs overlapped with transposable elements (TEs) and significantly impacted sequence diversity, expression variation, and tissue-specific expression. DNA methylation explained approximately 32% of the expression variation of lncRNAs across accessions. Selective sweeps revealed 857 and 519 lncRNAs under domestication and improvement, respectively. These selected lncRNAs were associated with traits such as fruit size, sugar content, and stone cell content. Metabolome profiling revealed a consistent reduction in lignin-related metabolites during pear domestication and improvement. Integrating transcriptome and metabolome analyses, we established a lncRNA-mRNA co-expression network associated with lignin biosynthesis. The regulatory role of lncRNA-pys within this network was functionally validated through transgenic experiments, demonstrating that overexpressing lncRNA-pys led to an increase in lignin content in pear. This study represents the first effort to unveil the contributions of lncRNAs under human selection to the domestication traits of fruit crops.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symmetry-Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies (Adv. Sci. 62/2026) 非平凡等离子体拓扑激励的对称强制选择规则（Sci. 62/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-09 DOI: 10.1002/advs.78410

Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng-Wei Qiu, Xuezhi Zheng

{"title":"Symmetry-Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies (Adv. Sci. 62/2026)","authors":"Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng-Wei Qiu, Xuezhi Zheng","doi":"10.1002/advs.78410","DOIUrl":"https://doi.org/10.1002/advs.78410","url":null,"abstract":"Excitations of Nontrivial Plasmonic TopologiesA set of unified symmetry-imposed selection rules governing the excitation of multidimensional plasmonic near field topologies with singularities is proposed. Derived from symmetry principles, the rules predict spin-orbit vortex splitting, multidimensional nested vortices, and topological transitions among different optical quasiparticles, confirmed by phase-resolved in-situ measurements. This symmetry framework enables the design of multidimensional nontrivial nearfield topologies in singular electromagnetics. More details can be found in the Research Article by Jiafu Wang, Benfeng Bai, Cheng-Wei Qiu, Xuezhi Zheng, and co-workers (DOI: 10.1002/advs.77043).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 62","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.78410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149369502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0