Advanced Science最新文献_第2页

Correction to “Seedless One-Pot Synthesis of Colloidal InAs Quantum Dots Enabling a High-Accuracy Photoplethysmography Oximeter” 修正“胶体InAs量子点的无籽单锅合成，实现高精度光体积脉搏描记血氧仪”。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-29 DOI: 10.1002/advs.77497

{"title":"Correction to “Seedless One-Pot Synthesis of Colloidal InAs Quantum Dots Enabling a High-Accuracy Photoplethysmography Oximeter”","authors":"","doi":"10.1002/advs.77497","DOIUrl":"10.1002/advs.77497","url":null,"abstract":"B. K. Kim, S. Jee, Y. Ahn, et al. “Seedless One-Pot Synthesis of Colloidal InAs Quantum Dots Enabling a High-Accuracy Photoplethysmography Oximeter.” Advanced Science 13, no. 38 (2026): e24375. https://doi.org/10.1002/advs.202524375We have just noticed that one of the grant numbers in the Acknowledgements section was entered incorrectly. The grant number was published as RS-2025-24563595, whereas the correct number is RS-2025-24523595.Nevertheless, as accurate funding information is important, we would be very grateful if you could kindly consider correcting the Acknowledgements section as follows:“This work was supported by Korea Research Institute for Defense Technology Planning and Advancement (KRIT) Grant funded by Defense Acquisition Program Administration (DAPA) (KRIT-CT-23-031); the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT, RS-2025-24523595, RS-2025-02316659); the Korea Research Institute of Standards and Science (KRISS-JP2026-0052, KRISS-GP2026-0001); and by the Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute for Advancement of Technology (KIAT) through the International Cooperative R&D program (P0028887).”We apologize for this error.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application 体内直接重编程：从机制到治疗应用的当前进展和未来展望。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-21 DOI: 10.1002/advs.77370

Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim

{"title":"In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application","authors":"Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim","doi":"10.1002/advs.77370","DOIUrl":"10.1002/advs.77370","url":null,"abstract":"Direct reprogramming, which converts somatic cells from one lineage to another without passing through a pluripotent state, represents a promising therapeutic strategy for regenerative medicine. Recent advancements in identifying reprogramming factors and understanding molecular barriers have enabled efficient generation of therapeutically relevant cells. Yet, the clinical application of in vitro-derived reprogrammed cells is hampered by the immature phenotype, hostile microenvironments, low engraftment, and poor survival after transplantation. In vivo direct reprogramming of tissue-resident cells within their native tissue microenvironment offers a compelling alternative to overcome these barriers. Harnessing biochemical and biophysical cues of the tissue microenvironment, this approach facilitates the acquisition of molecular and functional features resembling endogenous cells. This review summarizes the current understanding of in vivo direct reprogramming, covering mechanisms, key reprogramming factors, and delivery strategies, and explores therapeutic applications across organ systems. Finally, key challenges such as delivery efficiency, incomplete understanding of tissue cues, and limited mechanistic insights, along with emerging strategies, are discussed.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protease-Triggered Chromogenic Release From Peptide-Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity (Adv. Sci. 58/2026) 肽修饰碳酸钙微球的蛋白酶触发显色释放用于牙龈卟啉单胞菌活性的比色检测（Adv. Sci. 58/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 DOI: 10.1002/advs.77865

Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst

引用次数: 0

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring 肿瘤暴露组学：个体化持续暴露监测的新范式。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-06 DOI: 10.1002/advs.77568

Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou

{"title":"Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring","authors":"Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou","doi":"10.1002/advs.77568","DOIUrl":"10.1002/advs.77568","url":null,"abstract":"Exposomics provides a systems-level framework to characterize the environmental exposures experienced across the life course and their biological consequences, offering critical insights into tumor initiation and precision prevention. Advances in sensing technologies, intelligent materials, and data science now enable continuous acquisition of external exposures alongside endogenous molecular and phenotypic responses. In this emerging paradigm, exposure is conceptualized not as an isolated variable statistically associated with disease, but as a temporally structured driver embedded within multiscale biological processes. By integrating multimodal monitoring with AI-enabled causal modeling, exposomics moves cancer risk assessment beyond population averages toward individualized, dynamically updated exposure-informed risk assessment. This Perspective highlights key technological directions in external-internal monitoring integration, intelligent sensing ecosystems, and causal data fusion, and outlines a translational framework aimed at supporting precision cancer prevention and early risk management.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics 将脑类器官转化为功能平台：工程、成像、人工智能和伦理的融合。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-29 DOI: 10.1002/advs.202523506

Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria

{"title":"Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics","authors":"Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria","doi":"10.1002/advs.202523506","DOIUrl":"10.1002/advs.202523506","url":null,"abstract":"Brain organoids are self-organizing 3D aggregates derived from pluripotent stem cells and thus mirror many aspects of human brain development, including gene expression programs, spatial organization, and neuron subtype specification. As a result, these organoids have been used to emulate neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. Yet, their maturation remains fundamentally constrained by diffusion-limited necrosis, incomplete vascularization, limited visualization, and the absence of large-scale circuit integration, which collectively prevent progression beyond the fetal stage. These intrinsic limitations have catalyzed a convergence across microfluidics, biofabrication, imaging, and ethical frameworks, giving rise to a multidisciplinary movement aimed at enhancing organoid viability, reproducibility, and physiological relevance. This perspective examines how these technologies are transforming brain organoids from developmental models into experimentally robust, functional platforms.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: (Adv. Sci. 58/2026) 发行信息：（ad . Sci. 58/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 DOI: 10.1002/advs.77867

引用次数: 0

Translational Barriers and AI-Driven Challenges of Microfluidics-Enabled Wearables and Implantable Systems in Personalized Medicine 个性化医疗中微流控可穿戴设备和植入式系统的转化障碍和人工智能驱动的挑战。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-27 DOI: 10.1002/advs.77296

Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo

{"title":"Translational Barriers and AI-Driven Challenges of Microfluidics-Enabled Wearables and Implantable Systems in Personalized Medicine","authors":"Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo","doi":"10.1002/advs.77296","DOIUrl":"10.1002/advs.77296","url":null,"abstract":"Wearable and implantable microfluidic systems have progressed from laboratory prototypes toward translational clinical deployment, enabling continuous, minimally invasive sampling of dynamic biomarkers across sweat, saliva, tears, and interstitial fluid. However, existing reviews often address materials chemistry or device fabrication in isolation, obscuring the systemic path to clinical translation. This review establishes a cohesive, translation-focused linear trajectory starting from foundational functional biomaterials and advanced fabrication techniques, transitioning into a performance benchmarking of diagnostics-oriented systems and closed-loop theranostic platforms. Through these vectors, we systematically evaluate how microfluidic transport, multiplexed molecular analytics, and autonomous therapeutic integration collectively drive the shift from passive tracking to adaptive intervention. Beyond physical hardware, we decode the integration of artificial intelligence (AI) across three precise pathways: sensor self-calibration, multiplexed molecular decoding, and on-device autonomous decision-making. Finally, we critically examine the socio-technical barriers to clinical translation, with a focus on how biofluid data heterogeneity and population baseline disparities propagate algorithmic bias. We propose that robust hardware interfaces, standardized validation benchmarks, and alignment with emerging regulatory frameworks are prerequisites for achieving equitable, responsible digital health protection.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Thirty-Year Gap: Reviving All-Nitride Glasses as Processable, High-Performance Materials 三十年的差距：恢复全氮玻璃作为可加工的高性能材料。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-27 DOI: 10.1002/advs.77963

Alexis Duval, Tor Grande, Lothar Wondraczek

{"title":"A Thirty-Year Gap: Reviving All-Nitride Glasses as Processable, High-Performance Materials","authors":"Alexis Duval, Tor Grande, Lothar Wondraczek","doi":"10.1002/advs.77963","DOIUrl":"10.1002/advs.77963","url":null,"abstract":"This study revisits oxygen-free, all-nitride glasses as a distinct class of high-performance materials, originally reported three decades ago by Grande, Holloway, McMillan, and Angell. A novel glass family at the time, such glass systems have remained unreplicated, largely due to the highly specialized experimental conditions required for their synthesis. With contemporary advances, such constraints are no longer prohibitive. Rather, in light of the persistent challenges in enhancing the performance of conventional glass systems, all-nitride glasses are reconsidered herein as a potentially viable class of processable materials that combine the formability of glasses with ceramic-level performance–without compromising optical transparency. Building upon progress in the modeling and computational evaluation of glass properties, a thermodynamic and semi-empirical framework is established to delineate the accessible chemical space and to estimate key properties, including liquidus temperature, density, elastic modulus, and refractive index. This approach enables assessment of the attainable property realm, which is shown to far surpass that of oxide glasses, consistent with experimental trends observed in oxynitride systems. Prospective processing routes, functionalization strategies, and high-performance applications are discussed in light of overcoming supply chain risks associated with materials in current use.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation 超分子降解：靶向蛋白质降解的新兴范例。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-13 DOI: 10.1002/advs.77305

Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong

{"title":"Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation","authors":"Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong","doi":"10.1002/advs.77305","DOIUrl":"10.1002/advs.77305","url":null,"abstract":"Targeted protein degradation (TPD) redirects endogenous protein-disposal pathways to selectively eliminate therapeutically relevant proteins. Over the past two decades, this field has progressed from proteolysis-targeting chimeras (PROTACs) to an expanding repertoire of proteasomal and lysosomal degradation strategies. Recent studies indicate that supramolecular strategies are emerging in TPD, with dynamic noncovalent interactions and ordered assembly shaping degrader construction, delivery, functional integration, or intracellular assembly or activation. Here we organize recent advances into four major modes of supramolecular involvement, encompassing noncovalent modular decoupling of degrader components, delivery-oriented single-component self-assembly, multicomponent co-assembly for functional integration, and intracellular in situ assembly that generates either persistent local architectures or active degraders following cellular entry. We discuss their applications across proteasomal, endosomal-lysosomal, and autophagy-lysosomal degradation pathways. Finally, we discuss translational challenges and emerging opportunities for advancing supramolecular degraders, spanning modular design, strategy diversification, indication selection, systemic biodistribution, intracellular trafficking, safety assessment, and the prospective use of artificial intelligence (AI)-assisted modeling.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13572836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroforming-Free, Self-Rectifying Selector-Only Memory With Diffusive Cu-Ion Dynamics for Logic-In-Memory Computing (Adv. Sci. 58/2026) 基于cu离子扩散动力学的无电铸自整流选择器存储器（物理学报，58/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 DOI: 10.1002/advs.77866

Jae-Kyeong Kim, Dae-Seong Woo, Min-Jong Han, Hong-Gwang Seo, Gwang-Ho Park, In-Taek Woo, Jea-Gun Park, Jinsub Park

引用次数: 0