Advanced Science最新文献_第2页

Microporous Polymer Membranes: Molecular Stents Enhanced Solvent-Accessibility for Organic Solvent Transport. 微孔聚合物膜：分子支架增强有机溶剂运输的溶剂可及性。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202416748

Shuang Guo, Chuanjie Fang, Jiaqi Li, Xiaohe Wang, Weilin Feng, Hukang Guo, Ming Xie, Yongbing Zhuang, Young Moo Lee, Liping Zhu

{"title":"Microporous Polymer Membranes: Molecular Stents Enhanced Solvent-Accessibility for Organic Solvent Transport.","authors":"Shuang Guo, Chuanjie Fang, Jiaqi Li, Xiaohe Wang, Weilin Feng, Hukang Guo, Ming Xie, Yongbing Zhuang, Young Moo Lee, Liping Zhu","doi":"10.1002/advs.202416748","DOIUrl":"https://doi.org/10.1002/advs.202416748","url":null,"abstract":"Microporous polymer membranes with high solvent permeability are pivotal for upgrading molecular separations in organic solvents, but this remains challenging due to numerous sub-0.4 nm ultra-micropores resulting from local tight packing, which limit solvent-accessibility. Herein, a microporous polyimide with high intrinsic free volume [PI-TB-NDI, naphthalenediimide (NDI) and Tröger's base (TB)] is synthesized for organic solvent nanofiltration. The resulting polymer showed high free volume because of fused aromatic rings and a twisted structure. Aromatic rings enhanced solvent resistance due to strong molecular interaction, but increased detrimental local tight packing as well. To suppress local tight packing without compromising the molecular interactions vital for stability, an ortho-methyl group is deliberately introduced onto the TB unit to increase both intra- and inter-molecular steric hindrance, imparting an H-shaped TB-NDI-TB molecular stent. On the introduction of ortho-methyl groups, the sub-0.4 nm ultra-micropores are enlarged to ultra-micropores (0.6-0.7 nm) to give the membrane with rich solvent-accessible sub-nanochannels. This resulted in an unprecedented enhancement of solvent permeability, with ethanol permeability 2-8 times greater than that of state-of-the-art polymer membranes with similar selectivity. These findings advance the design strategy of microporous membranes with well-tailored free volume without post-treatments, enabling upscaling and efficient separation of precious species in organic solvents.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e16748"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Thermalization Dynamics of Fermi Gases Quenched to the BEC-BCS Crossover. BEC-BCS交叉淬灭费米气体的量子热化动力学。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202507343

Licheng Yi, Shuxian Yu, Meimei Wu, Shujin Deng, Haibin Wu

{"title":"Quantum Thermalization Dynamics of Fermi Gases Quenched to the BEC-BCS Crossover.","authors":"Licheng Yi, Shuxian Yu, Meimei Wu, Shujin Deng, Haibin Wu","doi":"10.1002/advs.202507343","DOIUrl":"https://doi.org/10.1002/advs.202507343","url":null,"abstract":"Understanding nonequilibrium dynamics of strongly interacting quantum systems represents one of the most challenging problems in many-body physics. Here, quantum thermalization dynamics are explored in real-time in an ultracold Fermi gas suddenly quenched to the BEC-BCS crossover. When quenched to unitarity, it is observed that the cloud size remains unchanged in the early evolution while the momentum distribution emerges two prethermal states with a lifetime difference of two orders of magnitude in the early and intermediate stage before very slowly evolving to the final stationary state. It is revealed that a crossover momentum, at which the momentum distribution remains nearly unchanged, is determined by the thermal wavelength at high temperatures and the Fermi momentum while at low temperatures. It is identified that the universal prethermal dynamics scaling where momentum distributions with different temperatures collapse onto one curve. When quenched to the BEC side, the thermalization rapidly relaxes into a prethermal state and exhibits the low energy oscillation related to the molecular bound states. This work provides benchmarks for the study of quantum thermalization in strongly interacting fermionic many-body systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07343"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: (Adv. Sci. 20/2025) 发布信息：（科学通报20/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202570152

引用次数: 0

Superconducting Carbon-Cage Network with T_c of 109 K at Ambient Pressure. 常温下Tc为109k的超导碳笼网。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202504281

Z F Ye, David J Singh, Y N Huang, Guo-Hua Zhong, Hai-Qing Lin

引用次数: 0

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer. 整合组织病理微环境和EHR表型的可解释的多模态人工智能模型用于乳腺癌种系基因检测。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202502833

Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu

{"title":"An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer.","authors":"Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu","doi":"10.1002/advs.202502833","DOIUrl":"https://doi.org/10.1002/advs.202502833","url":null,"abstract":"Genetic testing for pathogenic germline variants is critical for the personalized management of high-risk breast cancers, guiding targeted therapies and cascade testing for at-risk families. In this study, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing) is proposed, a deep learning framework that integrates histopathological microenvironment features from whole-slide images with clinical phenotypes from electronic health records for precise prescreening of germline BRCA1/2 mutations. Leveraging a multi-scale Transformer-based deep generative architecture, MAIGGT employs a cross-modal latent representation unification mechanism to capture complementary biological insights from multimodal data. MAIGGT is rigorously validated across three independent cohorts and demonstrated robust performance with areas under receiver operating characteristic curves of 0.925 (95% CI 0.868 - 0.982), 0.845 (95% CI 0.779 - 0.911), and 0.833 (0.788 - 0.878), outperforming single-modality models. Mechanistic interpretability analyses revealed that BRCA1/2-mutated associated tumors may exhibit distinct microenvironment patterns, including increased inflammatory cell infiltration, stromal proliferation and necrosis, and nuclear heterogeneity. By bridging digital pathology with clinical phenotypes, MAIGGT establishes a new paradigm for cost-effective, scalable, and biologically interpretable prescreening of hereditary breast cancer, with the potential to significantly improve the accessibility of genetic testing in routine clinical practice.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02833"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets. 哺乳动物胰岛双激素细胞和内分泌细胞系的综合表征。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202416326

Xin-Xin Yu, Peng Peng, Yi-Ning Wang, Mao-Yang He, Shuang He, Chen-Tao Jin, Liu Yang, Xi Wang, Jia-Xi Zheng, Jie Gao, Cheng-Ran Xu

{"title":"Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets.","authors":"Xin-Xin Yu, Peng Peng, Yi-Ning Wang, Mao-Yang He, Shuang He, Chen-Tao Jin, Liu Yang, Xi Wang, Jia-Xi Zheng, Jie Gao, Cheng-Ran Xu","doi":"10.1002/advs.202416326","DOIUrl":"https://doi.org/10.1002/advs.202416326","url":null,"abstract":"Understanding the role and prevalence of bihormonal cells in pancreatic islets and their potential in β-cell restoration is critical but remains ambiguous. Using genetically engineered mouse strains with specific fluorescent markers and advanced imaging flow cytometry, it is found that bihormonal cells are exceedingly rare. Single-cell RNA sequencing reveals that Gcg+Ppy+ and Gcg+Ins+ bihormonal cells closely resemble α-cells or PP-cells and α-cells, respectively, indicating they are neither unique lineages nor transitional states. Dual-recombinase lineage tracing further demonstrates that embryonic Gcg+Ins+ cells resolve into monohormonal α-cells. Applying these insights, the scarcity of bihormonal cells in diabetic mouse models is confirmed, suggesting a limited role in β-cell regeneration. By excluding bihormonal influences, endocrine cell classification is redefined in mouse and human islets through gene coexpression network analysis, identifying distinct subtypes and regulatory modules while uncovering species-specific differences. Additionally, two unique δ-cell subpopulations are identified in human islets. Collectively, this study provides a comprehensive characterization of bihormonal cells, refines endocrine cell taxonomy, and underscores the translational challenges in modeling human islet biology in mice.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e16326"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa. 基因组变异支持双叶田葵遗传分化和不同的盐适应能力。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202502600

Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu-Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao

{"title":"Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa.","authors":"Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu-Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao","doi":"10.1002/advs.202502600","DOIUrl":"https://doi.org/10.1002/advs.202502600","url":null,"abstract":"Halophytes possess inherent stress resilience and diverse adaptations, making them valuable genetic reservoirs for crop breeding. The leguminous halophyte Sesbania bispinosa is a valuable forage crop that thrives in saline soils. To explore its salt tolerance, high-quality genome assemblies is generated for the salt-tolerant S. bispinosa accession SbTA02 and the salt-sensitive accession SbSA44. Genomic analysis revealed that the genomic divergence between the two accessions primarily originates from their pericentromeric and centromeric regions, which contain the two largest inversions: a >27-Mb inversion on chromosome 5 and a ≈49-Mb inversion on chromosome 6. Population-level analysis revealed that the 27-Mb inversion is widespread in S. bispinosa, dividing the tested populations into inland and coastal groups. These groups have many genetic divergence regions (GDRs), with genetically isolated haplotypes in the middle section of chromosome 5, including the large inversion and centromeric regions. Genome-wide association studies (GWAS) identified significant salt-tolerance signals in the GDRs, pinpointing the anthocyanidin synthase gene SbANS. Natural variation in SbANS is associated with differences in salt tolerance between salt-tolerant and salt-sensitive S. bispinosa accessions. These findings provide insights into the genomic evolution of the Sesbania genus and shed light on how genomic variation shapes genome architecture, genetic divergence, and phenotypic differentiation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02600"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Area High-Performance Thin Film Solid Oxide Fuel Cell with Nanoscale Anode Functional Layer by Scalable Reactive Sputtering. 具有纳米级阳极功能层的大面积高性能薄膜固体氧化物燃料电池。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202502504

Kyoungjae Ju, Seongkook Oh, Jong Hyuk Lee, Hyong June Kim, Hyunmin Kim, Sung Eun Jo, Juhwan Lee, Byung Chan Yang, Jisung Yoon, Dong Won Shin, Wanwoo Park, Ji-Won Son, Young-Beom Kim, Sungeun Yang, Jihwan An

{"title":"Large Area High-Performance Thin Film Solid Oxide Fuel Cell with Nanoscale Anode Functional Layer by Scalable Reactive Sputtering.","authors":"Kyoungjae Ju, Seongkook Oh, Jong Hyuk Lee, Hyong June Kim, Hyunmin Kim, Sung Eun Jo, Juhwan Lee, Byung Chan Yang, Jisung Yoon, Dong Won Shin, Wanwoo Park, Ji-Won Son, Young-Beom Kim, Sungeun Yang, Jihwan An","doi":"10.1002/advs.202502504","DOIUrl":"https://doi.org/10.1002/advs.202502504","url":null,"abstract":"For high-performance thin-film solid oxide cells (TF-SOCs), a nanostructured anode functional layer (n-AFL) that can prolong the triple-phase boundary (TPB) is crucial, particularly for low-temperature operation. However, the implementation of n-AFL (usually >1 µm in thickness) has critical issues in scale-up and productivity. Here, the study successfully demonstrates a large-area, high-performance TF-SOFC with an n-AFL fabricated via mass-production-compatible reactive magnetron sputtering. The cell with optimized n-AFL by adjusting crucial reactive-sputtering process parameters, i.e., oxygen partial pressure and sputtering power, shows superior performance compared to that of the cell without n-AFL: the reduction both in ohmic and anodic polarization resistances by 63% and 34%, respectively, and the improvement in maximum power density by 89% (0.705 W cm-2 vs 1.333 W cm-2) at 650 °C. When employed in large-scale cell (4 × 4 cm2), the TF-SOFC with n-AFL showed 19.4 W at 650 °C.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2502504"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC (Adv. Sci. 20/2025) 人类PDAC中癌症相关成纤维细胞的转录组图谱（Adv. Sci. 20/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202570155

Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang

引用次数: 0

Gut Microbiota-Butyrate-PPARγ Axis Modulates Adipose Regulatory T Cell Population (Adv. Sci. 20/2025) 肠道微生物-丁酸酯- ppar γ轴调节脂肪调节性T细胞群（Adv. Sci. 20/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202570151

Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu

{"title":"Gut Microbiota-Butyrate-PPARγ Axis Modulates Adipose Regulatory T Cell Population (Adv. Sci. 20/2025)","authors":"Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu","doi":"10.1002/advs.202570151","DOIUrl":"https://doi.org/10.1002/advs.202570151","url":null,"abstract":"Gut Microbiota-Butyrate-PPARγThis study demonstrates that gut microbiota-derived butyrate promotes adipose ST2+ regulatory T cell population through PPARγ activation. The cover illustration depicts gut microbiota (represented by orange-shaped bacterial cells) releasing butyrate (represented as blue particles and blue molecular structures), which transmit electrical-like signals to activate ST2+ regulatory T cells (shown in purple) in adipose tissue (orange cells), highlighting their role in maintaining adipose tissue immune homeostasis. More details can be found in article number 2411086 by Weiqing Wang, Ruixin Liu, and co-workers. Cover design by Rui Xie.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 20","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0