Advanced Science最新文献

筛选
英文 中文
Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring. 原位电生理监测中基于oect逆变器的动态调制。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202512755
Guohong Hu, Qijun Cai, Zhenglei Liu, Rongsheng Zeng, Liang-Wen Feng, Jianhua Chen, Shiji Xiahou, Wei Huang
{"title":"Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring.","authors":"Guohong Hu, Qijun Cai, Zhenglei Liu, Rongsheng Zeng, Liang-Wen Feng, Jianhua Chen, Shiji Xiahou, Wei Huang","doi":"10.1002/advs.202512755","DOIUrl":"https://doi.org/10.1002/advs.202512755","url":null,"abstract":"<p><p>Organic electrochemical transistors (OECTs) and their related circuits have emerged as a promising platform for biosensors and neuromorphic electronics, benefiting from their sub-1 V operation voltage, flexibility, biocompatibility, etc. However, operation instability, induced by complex microstructure variations and undesired side reactions during repeated redox processes, poses tremendous challenges for reliable and robust functions. Here, a dynamic modulating system is presented that can actively control the working condition of an OECT-based inverter and maintain high-voltage amplification capability through real-time voltage transfer characteristic scanning and operating voltage adjustment. Especially, under system modulation, the inverter maintains a high-voltage amplification capability with a voltage gain >34.58 V V<sup>-1</sup>. While without modulation (i.e., at a fixed input voltage), the voltage gain rapidly deteriorates to 3.11 V V<sup>-1</sup>. Thereafter, stretchable complementary circuits are fabricated and integrated with this system to enable high-fidelity in situ monitoring of the electrooculogram with >32.59 dB signal-to-noise ratio for more than 90 min, thus establishing a reliable wearable biosensing method. This work provides a new strategy to enable highly stable operation of bioelectronics with devices holding inferior stabilities.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12755"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defect-Engineered Bulk Conversion Anodes for Fast and Temperature-Adaptive Na+ Storage. 用于快速和温度自适应Na+存储的缺陷工程批量转换阳极。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202515276
Yanli Zhou, Ao Xu, Zhiqi Li, Yifei Wang, Jiawen Yan, Fuyi Jiang, Wei Liu, Xin Gu, Huan Pang, Jian Yang
{"title":"Defect-Engineered Bulk Conversion Anodes for Fast and Temperature-Adaptive Na<sup>+</sup> Storage.","authors":"Yanli Zhou, Ao Xu, Zhiqi Li, Yifei Wang, Jiawen Yan, Fuyi Jiang, Wei Liu, Xin Gu, Huan Pang, Jian Yang","doi":"10.1002/advs.202515276","DOIUrl":"https://doi.org/10.1002/advs.202515276","url":null,"abstract":"<p><p>Conversion-based metal sulfides/selenides anodes are promising for sodium-ion batteries (SIBs) owing to their high capacities and good electronic conductivity. However, their large volumetric variation during cycling often leads to rapid capacity decay, hindering commercial applications. Meanwhile, developing a low-cost and efficient synthesis strategy to enhance sodium storage remains challenging. Herein, defect engineering is introduced in bulk Fe<sub>7</sub>Se<sub>8</sub> (bulk-Fe<sub>7</sub>Se<sub>8-x</sub>) to fabricate a carbon-free and defect-rich anode. The optimized bulk-Fe<sub>7</sub>Se<sub>8-x</sub> realizes remarkable fast-charging performance and good temperature adaptability, achieving excellent cyclic stability (384 mAh g<sup>-1</sup> after 1300 cycles at 5 A g<sup>-1</sup> and 25 °C, 170.6 mAh g<sup>-1</sup> after 1000 cycles at 2 A g<sup>-1</sup> and 0 °C, and 371.7 mAh g<sup>-1</sup> after 500 cycles at 5 A g<sup>-1</sup> and 40 °C) and ultrahigh rate capability (up to 40 A g<sup>-1</sup>), significantly surpassing reported Fe<sub>7</sub>Se<sub>8</sub> anodes. Reaction mechanism and reaction kinetics are elucidated through in/ex situ characterization, kinetics analysis, and DFT calculations. Furthermore, the exploration of full cells demonstrates their potential application of bulk-Fe<sub>7</sub>Se<sub>8-x</sub> in SIBs. The universal strategy is also successfully applied to synthesize the high-performance, defect-rich bulk-Fe<sub>7</sub>S<sub>8-x</sub> and bulk-CoSe<sub>2-x</sub>, which provides an effective approach for other conversion-based anode materials.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15276"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle. 激活USP30通过调节s -腺苷蛋氨酸循环破坏内皮细胞功能并加重急性肺损伤
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202512807
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao
{"title":"Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle.","authors":"Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao","doi":"10.1002/advs.202512807","DOIUrl":"https://doi.org/10.1002/advs.202512807","url":null,"abstract":"<p><p>Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and leukocyte infiltration into interstitial tissues. Despite substantial research efforts, the precise mechanisms remain partially elucidated. Here, it is identified that USP30 is a critical regulator of lung microvascular inflammation and endothelial cell (EC) barrier integrity. Lipopolysaccharide (LPS) induces deubiquitinase activity of USP30. It is demonstrated that USP30 activation exacerbates EC dysfunction. Inhibiting USP30 leads to a 50% attenuation of inflammatory responses in ECs. In vivo, EC-specific USP30-deficient mice exhibit reduced microvascular dysfunction in models of endotoxin-induced and ischemia-reperfusion lung injury. Inhibition of USP30 preserves EC function via a mitophagy-independent mechanism involving the S-adenosylmethionine (SAM) cycle, DNA methylation, and miR-30a-5p expression. Mechanistically, USP30 depletion destabilizes and reduces methionine adenosyltransferase 2A (MAT2A) by deubiquitination, which in turn lowers SAM levels by ≈40%, and decreases global DNA methylation by roughly 35%, thereby resulting in a fourfold upregulation of miR-30a-5p. Elevated miR-30a-5p suppresses MDM2 and NFAT5 expression, contributing to the maintenance of EC function. These findings highlight that targeting USP30 may represent a potential therapeutic strategy warranting further preclinical and clinical exploration in acute lung injury.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12807"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic eIF3-S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts (Adv. Sci. 39/2025) m6A修饰诱导的eIF3-S6动态相分离开关驱动蝗虫换羽(ei)
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.71949
Zhihao Hu, Yu Zhou, Huimin Wang, Yaxi Wu, Rui Han, Shili Liu, Feng Jiang, Xiaojiao Guo, Meiling Yang
{"title":"Dynamic eIF3-S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts (Adv. Sci. 39/2025)","authors":"Zhihao Hu,&nbsp;Yu Zhou,&nbsp;Huimin Wang,&nbsp;Yaxi Wu,&nbsp;Rui Han,&nbsp;Shili Liu,&nbsp;Feng Jiang,&nbsp;Xiaojiao Guo,&nbsp;Meiling Yang","doi":"10.1002/advs.71949","DOIUrl":"https://doi.org/10.1002/advs.71949","url":null,"abstract":"<p><b>Molting of locusts</b></p><p>Molting is critical for insect development and growth. The migratory locust <i>Locusta migratoria</i>, a worldwide pest species, undergoes five molting stages in its life cycle and has been widely used as a model for studying the molting development. In their Research Article (DOI: 10.1002/advs.202510505), Meiling Yang, Zhihao Hu, Xiaojiao Guo, and co-workers reveal a new mechanism in which m<sup>6</sup>A modified <i>EcR</i> and <i>Cht10</i> instruct a phase separation-switch of eIF3-S6 for successful molting. The photo shows a locust undergoing molting from the fifth-instar nymph to adult stage. lmage credit: Meiling Yang and Zhihao Hu.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 39","pages":""},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/advs.71949","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ Structural Evolution and Activity Descriptor of Atomically Dispersed Catalysts During Nitrate Electroreduction (Adv. Sci. 39/2025) 硝酸电还原过程中原子分散催化剂的原位结构演化与活性描述子(Sci. 39/2025)
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.71951
Daniel S. Braga, Angus Pedersen, Mohd Riyaz, Jesús Barrio, Alexander Bagger, Itamar T. Neckel, Thiago M. Mariano, Manuel E. G. Winkler, Ifan E. L. Stephens, Maria-Magdalena Titirici, Raphael Nagao
{"title":"In Situ Structural Evolution and Activity Descriptor of Atomically Dispersed Catalysts During Nitrate Electroreduction (Adv. Sci. 39/2025)","authors":"Daniel S. Braga,&nbsp;Angus Pedersen,&nbsp;Mohd Riyaz,&nbsp;Jesús Barrio,&nbsp;Alexander Bagger,&nbsp;Itamar T. Neckel,&nbsp;Thiago M. Mariano,&nbsp;Manuel E. G. Winkler,&nbsp;Ifan E. L. Stephens,&nbsp;Maria-Magdalena Titirici,&nbsp;Raphael Nagao","doi":"10.1002/advs.71951","DOIUrl":"https://doi.org/10.1002/advs.71951","url":null,"abstract":"<p><b>Single-Atom Catalysts</b></p><p>This cover illustrates the electrosynthesis of ammonia through the reduction of nitrate ions on metallic clusters formed from single atom catalysts. The artwork highlights the catalytic interface where molecular transformations occur, linking nanoscale reactions to sustainable fertilizer production. By converting pollutants into value-added products, this work envisions a green pathway toward circular nitrogen management and enhanced agricultural sustainability. More details can be found in the Research Article (DOI: 10.1002/advs.202510282) by Maria-Magdalena Titirici, Raphael Nagao, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 39","pages":""},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/advs.71951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbon Monoxide Nanomodulator Reverses Ischemia-Reperfusion Injury in Stroke: A Novel Dual-Channel Therapy Mode of Co-driving Neuroprotection and Neurogenesis. 一氧化碳纳米调节剂逆转脑卒中缺血再灌注损伤:一种共同驱动神经保护和神经发生的新型双通道治疗模式。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202512333
Xuegang Niu, Bin Gao, Hongyi Huang, Zesheng Li, Yibin Zhang, Quanlei Liu, Chao Zhang, Yang Dai, Jinkun Xu, Mingshan Liu, Yuanyuan Zhang, Yihe Wang, Penghu Wei, Yuanxiang Lin, Yongzhi Shan, Yumin Luo, Dezhi Kang, Guoguang Zhao
{"title":"Carbon Monoxide Nanomodulator Reverses Ischemia-Reperfusion Injury in Stroke: A Novel Dual-Channel Therapy Mode of Co-driving Neuroprotection and Neurogenesis.","authors":"Xuegang Niu, Bin Gao, Hongyi Huang, Zesheng Li, Yibin Zhang, Quanlei Liu, Chao Zhang, Yang Dai, Jinkun Xu, Mingshan Liu, Yuanyuan Zhang, Yihe Wang, Penghu Wei, Yuanxiang Lin, Yongzhi Shan, Yumin Luo, Dezhi Kang, Guoguang Zhao","doi":"10.1002/advs.202512333","DOIUrl":"https://doi.org/10.1002/advs.202512333","url":null,"abstract":"<p><p>Recanalization intervention has improved patient outcomes in ischemic stroke, but severe ischemia-reperfusion injury remains a major challenge, necessitating effective pharmacotherapy to reverse neuronal damage and recover neurofunctions. Traditional neuroprotection strategies aim to inhibit neuronal death, and are still insufficient to recover long-term neurological dysfunctions. In this work, it is found that carbon monoxide (CO) as a neuromodulator exerts a new role in promoting neurogenesis via the crosstalk between brain endothelial cells and neural stem cells, which is beyond its recognized roles in anti-inflammation and anti-oxidation. This reveals a new possibility to address the above challenge. Furthermore, this work develops a biomimetic and reactive oxygen species-activated CO nanogenerator to effectively penetrate blood-brain barrier, arrive in stroke-affected regions, and release CO in a controlled manner for an innovative dual-channel therapy strategy via co-driving neuroprotection and neurogenesis. This strategy further demonstrates its therapeutic effects on reversing brain injury and recovering neurofunctions in a mouse ischemic stroke model. This work reveals an important new role of CO, and further offers an advanced pharmacotherapy for long-term neurological dysfunctions in ischemic stroke.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12333"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Efficiency Semitransparent Solar Cells Based on Magnetron Sputtered Sb2S3 Thin Films. 基于磁控溅射Sb2S3薄膜的高效半透明太阳能电池。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202512103
Pankaj Kumar, Pawan Kumar, Joseph P Thomas, Alessandro Gradone, Nicola Gilli, Shujie You, Vittorio Morandi, Kam Tong Leung, Alberto Vomiero
{"title":"High-Efficiency Semitransparent Solar Cells Based on Magnetron Sputtered Sb<sub>2</sub>S<sub>3</sub> Thin Films.","authors":"Pankaj Kumar, Pawan Kumar, Joseph P Thomas, Alessandro Gradone, Nicola Gilli, Shujie You, Vittorio Morandi, Kam Tong Leung, Alberto Vomiero","doi":"10.1002/advs.202512103","DOIUrl":"https://doi.org/10.1002/advs.202512103","url":null,"abstract":"<p><p>Thin-film solar cells based on wide-bandgap antimony sulfide (Sb<sub>2</sub>S<sub>3</sub>) offer new possibilities for semitransparent building-integrated photovoltaics. In this report, impurity-free Sb<sub>2</sub>S<sub>3</sub> thin films are prepared by radio frequency magnetron sputtering. The optimized opaque devices obtain a high power conversion efficiency (PCE) of 4.6%. A detailed characterization is conducted to investigate the impact of annealing conditions on the morphology, crystal structure, composition, and optoelectronic properties of Sb<sub>2</sub>S<sub>3</sub> thin films, which are relevant to photovoltaic performance. Moreover, semitransparent solar cells are fabricated using highly compact Sb<sub>2</sub>S<sub>3</sub> films with thicknesses of 40, 60, and 80 nm. Using a superstrate device structure (FTO/TiO<sub>2</sub>/Sb<sub>2</sub>S<sub>3</sub>/P3HT-PEDOT:PSS/Au (≈10 nm)), these solar cells achieve PCEs of 2.0%, 2.6%, and 3.2%, respectively, while maintaining an average visible transmittance (AVT) of 15.5%, 13.5%, and 10.0%. The AVTs of the semitransparent devices are further enhanced by replacing the ultrathin Au top electrode with indium-doped tin oxide and using wide bandgap inorganic CuSCN as the hole transport layer instead of P3HT-PEDOT:PSS. Thus, the AVT improves to 20.5% (PCE: 2.0%) for semitransparent solar cells using 60 nm Sb<sub>2</sub>S<sub>3</sub>. This study demonstrates that sputtering is a promising deposition technique for high-quality ultrathin Sb<sub>2</sub>S<sub>3</sub> absorbers for semitransparent photovoltaics.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12103"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medium-Entropy Alloy/Oxide Nano Composite for High-Performing High-Temperature CO2 Electrolysis with Remarkable Carbon Deposition Resistance (Adv. Sci. 39/2025) 中熵合金/氧化物纳米复合材料在高性能高温CO2电解中的应用(vol . Sci. 39/2025)
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.71950
Jun Tong, Haewon Seo, Yunseo Choi, Ji-eun Won, Jinhong Park, Keun Hwa Chae, Jongsup Hong, Hye Jung Chang, Baowen Zhou, Rongchang Cao, Na Ni, Kyung Joong Yoon, Lei Zhu, Zhen Huang
{"title":"Medium-Entropy Alloy/Oxide Nano Composite for High-Performing High-Temperature CO2 Electrolysis with Remarkable Carbon Deposition Resistance (Adv. Sci. 39/2025)","authors":"Jun Tong,&nbsp;Haewon Seo,&nbsp;Yunseo Choi,&nbsp;Ji-eun Won,&nbsp;Jinhong Park,&nbsp;Keun Hwa Chae,&nbsp;Jongsup Hong,&nbsp;Hye Jung Chang,&nbsp;Baowen Zhou,&nbsp;Rongchang Cao,&nbsp;Na Ni,&nbsp;Kyung Joong Yoon,&nbsp;Lei Zhu,&nbsp;Zhen Huang","doi":"10.1002/advs.71950","DOIUrl":"https://doi.org/10.1002/advs.71950","url":null,"abstract":"<p><b>Entropy-Engineered Nanocatalysts</b></p><p>By integrating a medium-entropy alloy with oxide nanostructures, a new catalyst enables both high CO<sub>2</sub> conversion and resistance to carbon buildup in solid oxide electrolysis cells. This breakthrough opens opportunities for scalable hydrogen and e-fuel production, contributing to a sustainable energy future. More details can be found in the Research Article by Kyung Joong Yoon, Na Ni, Lei Zhu, and co-workers (DOI: 10.1002/advs.202508800).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 39","pages":""},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/advs.71950","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dendrobium Officinale-Derived Carbon Dots Nanozymes Alleviate Colitis by Orchestrating Intestinal Mucus-Epithelium-Immune Barriers. 铁皮石斛衍生碳点纳米酶通过调节肠道黏液-上皮-免疫屏障缓解结肠炎。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202512567
Chenxi Xu, Xiaoling Huang, Zhichao Deng, Ruiying Wang, Seyedalireza Ghazimirsaeid, Li Yao, Yuanyuan Zhu, Bowen Gao, Junlong Fu, Mingxin Zhang, Mei Yang, Mingzhen Zhang
{"title":"Dendrobium Officinale-Derived Carbon Dots Nanozymes Alleviate Colitis by Orchestrating Intestinal Mucus-Epithelium-Immune Barriers.","authors":"Chenxi Xu, Xiaoling Huang, Zhichao Deng, Ruiying Wang, Seyedalireza Ghazimirsaeid, Li Yao, Yuanyuan Zhu, Bowen Gao, Junlong Fu, Mingxin Zhang, Mei Yang, Mingzhen Zhang","doi":"10.1002/advs.202512567","DOIUrl":"https://doi.org/10.1002/advs.202512567","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a chronic inflammatory disorder driven by genetic susceptibility, immune dysregulation, and intestinal barrier dysfunction. Current therapies primarily target immune suppression but show limited efficacy in barrier repair. Here, carbon dots derived from the Chinese herbal medicine Dendrobium officinale (DO-CDs), which exhibit antioxidant enzyme activity, are synthesized using a hydrothermal method. These DO-CDs, characterized by an abundance of surface functional groups, are demonstrated to scavenge ROS, suppress M1 macrophage polarization, as well as downregulate pro-inflammatory cytokine expression. In both acute and chronic colitis models, DO-CDs demonstrate multimodal barrier-repair properties. It is shown that DO-CDs can notably restore colon length, reduce the infiltration of inflammatory cells, and enhance both the quantity of goblet cells and the expression of mucins. Furthermore, the expression of intestinal epithelial tight junction proteins is significantly upregulated following DO-CDs treatment, thereby effectively strengthening the intestinal epithelial barrier function. Importantly, DO-CDs modulate the Th1/Treg ratio by downregulating the proportions of dendritic cells and M1 macrophages, thus reestablishing intestinal immune homeostasis. These coordinated actions on the mucus-epithelium-immune triad demonstrate the unique capacity of DO-CDs for holistic barrier reconstruction. The work provides a mechanistic foundation for herbal precursor-derived carbon dots as multi-target therapeutics in IBD.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e12567"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Manipulation of Magnetic Domain Wall by Dual Spin-Orbit Torque in Synthetic Antiferromagnets. 合成反铁磁体中双自旋-轨道转矩对磁畴壁的有效操纵。
IF 14.1 1区 材料科学
Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202514598
Hiroto Masuda, Yuta Yamane, Takaaki Dohi, Takumi Yamazaki, Rajkumar Modak, Ken-Ichi Uchida, Jun'ichi Ieda, Mathias Kläui, Koki Takanashi, Takeshi Seki
{"title":"Efficient Manipulation of Magnetic Domain Wall by Dual Spin-Orbit Torque in Synthetic Antiferromagnets.","authors":"Hiroto Masuda, Yuta Yamane, Takaaki Dohi, Takumi Yamazaki, Rajkumar Modak, Ken-Ichi Uchida, Jun'ichi Ieda, Mathias Kläui, Koki Takanashi, Takeshi Seki","doi":"10.1002/advs.202514598","DOIUrl":"https://doi.org/10.1002/advs.202514598","url":null,"abstract":"<p><p>Current-induced domain-wall motion (CIDWM) in a synthetic antiferromagnet is a key phenomenon for developing potential high-density-packed magnetic domain-wall memory with fast operation. Here, CIDWM is reported in the antiferromagnetically-coupled two Co layers through the Ir interlayer sandwiched by the two Pt layers: Pt/Co/Ir/Co/Pt. The top and bottom Pt layers play a role for generating the spin current coming from the spin Hall effect, which gives rise to the dual spin-orbit torque (SOT) acting on the perpendicular magnetizations of the Co layers. Although a simple argument would predict that SOTs from top and bottom Pt layers cancel each other out, the dual SOT nucleates a reversed magnetic domain and drives the CIDWM effectively at current density of the order of 10<sup>11</sup> A m<sup>-2</sup>. This study also examines the effect of antisymmetric interlayer exchange coupling (AIEC) on CIDWM. A positive correlation between the magnitude of AIEC and the domain wall velocity is found, whereas the current density required for nucleating the reversed domain shows a negative correlation with the magnitude of AIEC. These facts suggest that the existence of AIEC improves the performance of CIDWM. The present results provide a new avenue to design SOT domain wall devices based on a synthetic antiferromagnet.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e14598"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信