Advanced Science最新文献_第10页

Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus-Vector-Plant Tripartite Interactions.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202416891

Xiao-Bin Shi, Hao Yue, Yan Wei, Evan L Preisser, Pei Wang, Jiao Du, Ji-Xing Xia, Kai-Long Li, Xin Yang, Jian-Bin Chen, Song-Bai Zhang, Zhan-Hong Zhang, Xu-Guo Zhou, De-Yong Zhang, Yong Liu

{"title":"Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus-Vector-Plant Tripartite Interactions.","authors":"Xiao-Bin Shi, Hao Yue, Yan Wei, Evan L Preisser, Pei Wang, Jiao Du, Ji-Xing Xia, Kai-Long Li, Xin Yang, Jian-Bin Chen, Song-Bai Zhang, Zhan-Hong Zhang, Xu-Guo Zhou, De-Yong Zhang, Yong Liu","doi":"10.1002/advs.202416891","DOIUrl":"https://doi.org/10.1002/advs.202416891","url":null,"abstract":"While interactions between viruses and their vectors, as well as between viruses and host plants, have been extensively studied, the genetic mechanisms underlying tripartite interactions remain largely unknown. In this study, phenotypic assays are integrated with molecular biology and functional genomic approaches to elucidate the tripartite interactions involving tomato chlorosis virus (ToCV), a major threat to tomato production worldwide, the whitefly, Bemisia tabaci, an insect vector, and host plants. ToCV infection induces the production of a chlorophyll degradation product that acts as a volatile attractant for whiteflies. Furthermore, the suppression of Lhca4, a gene encoding subunit of light-harvesting complex I in host plants, by the P9 protein of ToCV leads to chlorophyll degradation and neophytadiene biosynthesis. Overexpression of Lhca4 reduced chlorophyll production and ToCV infection. Furthermore, OBP2, an odorant-binding protein from B. tabaci, capable of binding to neophytadiene is identified. Suppression of BtOBP2 impaired vector's subsequent preference for ToCV-infected plants. The results not only reveal the genetic underpinnings, including ToCV P9, host plant Lhca4, and whitefly BtOBP2, governing the virus-vector-plant interactions, but also highlight neophytadiene, a specialized metabolite in host plants, as a mediator of intricate multitrophic interactions, suggesting new avenues for managing plant virus vectored by insects.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416891"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of Liquid Biopsy-Based Multi-Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE-I).

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202401760

Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang Liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen

{"title":"Performance of Liquid Biopsy-Based Multi-Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE-I).","authors":"Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang Liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen","doi":"10.1002/advs.202401760","DOIUrl":"https://doi.org/10.1002/advs.202401760","url":null,"abstract":"Liquid biopsy is a promising approach for early detection of gynecological malignancies. In the PERCEIVE-I study, gynecological Cancer cases (n = 249) and age-matched non-cancer controls (n = 249) are randomly divided into training and test sets at a 1:1 ratio. Data derived from multi-omics assays are obtained including a cell-free DNA methylation panel targeting ≈490 000 CpG sites, a mutation panel comprising 168 genes, and eight tumor protein markers. The results showed that the methylation model outperformed the protein and mutation models, demonstrating higher sensitivity (77.2%) while maintaining similar specificity. The multi-omics model combining methylation and protein markers achieved improved sensitivity (81.9%) with a good specificity (96.9%). The sensitivity varied across different stages, ranging from 66.7% to 100%. The model accurately identified the tissue of origin in 72.1% of cases. The superior performance of the methylation model highlights the potential of integrating multi-omics for non-invasive early detection of gynecological malignancies.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2401760"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Function of Photocatalytic Performance and Carrier Separation Efficiency Tuned by Doping Content in Homogeneous Photocatalysts.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202501026

Chunxia Wen, Xinyue Ni, Mei Han, Yue Yu, Chuanqiang Liu, Yuan Zhang, Beining Zheng, Shouhua Feng

{"title":"The Function of Photocatalytic Performance and Carrier Separation Efficiency Tuned by Doping Content in Homogeneous Photocatalysts.","authors":"Chunxia Wen, Xinyue Ni, Mei Han, Yue Yu, Chuanqiang Liu, Yuan Zhang, Beining Zheng, Shouhua Feng","doi":"10.1002/advs.202501026","DOIUrl":"https://doi.org/10.1002/advs.202501026","url":null,"abstract":"Homogeneous matrix materials are considered to be a solid guarantee of site-point charge transfer reactions because they are the main body of light absorption, photogenerated carrier separation, migration, and recombination processes. Elucidating the effect of carrier separation efficiency on catalytic performance is of great significance for overcoming the optimization obstacles of homogeneous matrix parts and providing new design strategies. In this study, TiO2 doped with Fe as the research object quantifies the carrier dynamics while trying to avoid large site and lattice changes. The direct correlation between carrier separation efficiency and photocatalytic performance with different doping content samples is clearly elucidated by carrier dynamic characterization results. Doping of 0.213 wt.% Fe exhibits the best catalytic performance, achieving CO yield of 35.12 µmol g-1 h-1. Especially, the femtosecond transient absorption spectroscopy demonstrates the defect level formed by doping Fe enhances the separation of photogenerated electrons. The clear relationship shown above, which is catalytic capacity mapping with carrier separation efficiency, rather than a linear dependence on sites and oxygen vacancies, fully demonstrates the great potential of simple doping strategies for homogeneous photocatalysts.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2501026"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrostatically Reinforced Double Network Granular Hydrogels.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202412566

Tianyu Yuan, Chenzhuo Li, John M Kolinski, Esther Amstad

{"title":"Electrostatically Reinforced Double Network Granular Hydrogels.","authors":"Tianyu Yuan, Chenzhuo Li, John M Kolinski, Esther Amstad","doi":"10.1002/advs.202412566","DOIUrl":"https://doi.org/10.1002/advs.202412566","url":null,"abstract":"Rapid advances in biomedical applications and soft robotics demand load-bearing soft materials that can be processed into complex 3D shapes. Direct ink writing (DIW) enables the fabrication of customizable shapes with locally varying compositions. Hydrogels that are formulated as microgels meet the rheological requirements that DIW imparts on the inks if they are jammed. However, most granular hydrogels are soft because inter-particle interactions are weak. These hydrogels can be reinforced with a second hydrogel, yielding double network granular hydrogels (DNGHs). Yet, DNGHs suffer from low fracture energy. This limitation is addressed by electrostatically reinforcing them. The resulting materials exhibit Young's moduli and fracture energies similar to values of cartilage and muscles. An empirical model is proposed to predict the fracture energy of these reinforced DNGHs, based on the dissipation zone size, contact area, and adhesion energy. These DNGHs can be 3D-N, N-methylene bisacrylamideprinted into free-standing structures exhibiting tuneable mechanical properties at the centimeter scale without the need for supporting structures.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412566"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squaraine Dyes for Organic Photomultiplication Photodetectors with 220% External Quantum Efficiency at 1240 nm.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202502320

Joshua Csucker, Elodie Didier, João Pedro Ferreira Assunção, Daniel Rentsch, Radha Kothandaraman, Dominik Bachmann, Ivan Shorubalko, Frank Nüesch, Roland Hany, Michael Bauer

{"title":"Squaraine Dyes for Organic Photomultiplication Photodetectors with 220% External Quantum Efficiency at 1240 nm.","authors":"Joshua Csucker, Elodie Didier, João Pedro Ferreira Assunção, Daniel Rentsch, Radha Kothandaraman, Dominik Bachmann, Ivan Shorubalko, Frank Nüesch, Roland Hany, Michael Bauer","doi":"10.1002/advs.202502320","DOIUrl":"https://doi.org/10.1002/advs.202502320","url":null,"abstract":"Near-infrared (NIR) light detection at wavelengths λ > 1100 nm is essential in modern science and technology. Emerging organic semiconductors are promising for solution-processed, flexible, and large-area NIR organic photodetectors (OPDs), but only a few organic chromophores with peak absorption beyond the silicon bandgap are available. Furthermore, the external quantum efficiency (EQE) and specific detectivity (D*) of NIR OPDs are restricted by insufficient exciton dissociation and high dark/noise current. Here, the combination of strong electron-accepting and -donating groups is used to synthesize a selection of novel NIR squaraine dyes with superior redshifted absorptions, peaking at 1165 nm in solution and extending to 1240 nm in a blend film. To overcome the tradeoff between long wavelength absorption and high photoresponse, NIR photons are detected utilizing a gain OPD design, where photomultiplication occurs via squaraine hole trap-induced injection of external charges. The OPD can achieve an EQE of 220% at 1240 nm and still maintains 25% in the absorption tail at 1400 nm, thereby surpassing existing NIR OPDs in a broad wavelength range beyond 1100 nm. The measured maximum D* equals 109 Jones at 1240 nm, and the detectivity estimated from the shot noise is ≈1011 Jones, independent of the bias voltage.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2502320"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell-Derived Exosomes for Suppressing Tumor Progression and Metastasis.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202500139

Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren

{"title":"Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell-Derived Exosomes for Suppressing Tumor Progression and Metastasis.","authors":"Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren","doi":"10.1002/advs.202500139","DOIUrl":"https://doi.org/10.1002/advs.202500139","url":null,"abstract":"Tumor-draining lymph nodes (TDLNs) are the primary sites of eliciting anti-tumor immunity, which play an important role in controlling tumor progression and metastasis. However, the immunosuppressive microenvironment of TDLNs propels the formation of pre-metastatic niche, in which the immunocytes are dysfunctional, and the high expression of programmed death-ligand 1 (PD-L1) on dendritic cells (DCs) restricts the activation of cytotoxic T lymphocytes. Herein, engineered exosomes (EmDEX@GA) are developed for locoregional immunomodulation of TDLNs. EmDEX@GA possess CC-chemokine receptor 7 (CCR7) -dependent LN homing capacity and over-expressed programmed cell death protein 1 (PD-1) for immune checkpoint blockade (ICB). The loaded stimulator of interferon genes (STING) agonist can reinforce anti-tumor immunity through STING pathway activation. In orthotopic breast cancer mouse model, local administration of EmDEX@GA remodels the immunosuppressive microenvironment of TDLNs and elicits potent anti-tumor immunity, resulting in the suppression of tumor as well as the reduction of lymph node metastasis and distant metastasis. Compared with systemic ICB, local immunotherapy with EmDEX@GA has better therapeutic efficacy on suppressing distant metastasis. Moreover, the study suggests that the occurrences of distant metastasis are associated with the immunosuppressive microenvironment rather than the metastasis in TDLNs, indicating that targeted immunomodulation of TDLNs is necessary.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500139"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Controlled Degradation of Enzyme Loaded PCL-Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202501053

Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen

{"title":"Robust Controlled Degradation of Enzyme Loaded PCL-Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration.","authors":"Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen","doi":"10.1002/advs.202501053","DOIUrl":"https://doi.org/10.1002/advs.202501053","url":null,"abstract":"Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on wound healing, such as secondary damage, undesirable inflammation, and scar skin formation. Here, an available strategy associated with the synthesis of enzyme-loaded (Burkholderia cepacia lipase, BCL) polycaprolactone (PCL) nanofiber scaffolds, aligning with wound healing effects is reported. These scaffolds are fabricated via fiber microfluidic electrospinning degradation-control technique. The obtained scaffolds exhibit tunable degradation rates, achieving complete degradation within 12-72-h cycles. The acidic degradation products are further elucidated and reveal the potential degradation mechanism. The acidic degradation products create an optimal microenvironment during the hemostasis and inflammation stages of wound healing. Notably, in vivo experiments demonstrate the enzyme-loaded scaffolds effectively promote angiogenesis, reduce inflammatory responses, mitigate collagen deposition, and regulate fibroblast differentiation. This promotes rapid wound healing with a remarkable scarless rate of over 99% by day 21. New guidelines for scar-free healing dressings are proposed, which carry out faster degradation without microplastics (MPs) and toxic byproducts before scar formation. These principles might provide valuable insights and promise for developing more effective wound dressings.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2501053"},"PeriodicalIF":14.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Efficiency, Long-Lifetime and Color-Tunable Hybrid WOLEDs Using a Platinum Complex with Voltage-Dependent Monomer and Aggregate Emission (Adv. Sci. 13/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202570092

Yangyang Xin, Mao Mao, Shuo Xu, Kaixin Tan, Gang Cheng, Hai Zhang, Hengyi Dai, Tianyu Huang, Dongdong Zhang, Lian Duan, Chi-Ming Che

引用次数: 0

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202413599

Guanghui Yang, Qiliang Xin, Jurrien Dean

引用次数: 0

Metabolic Engineering of Corynebacterium glutamicum for High-Level Production of 1,5-Pentanediol, a C5 Diol Platform Chemical (Adv. Sci. 13/2025)

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-04-03 DOI: 10.1002/advs.202570090

Yu Jung Sohn, Se-Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin-Byung Park, Si Jae Park

引用次数: 0