Advanced Science最新文献_第10页

Biomimetic Thermal Safety Strategies in Batteries for Electric Vehicles: from Biological Principles to Engineering Approaches. 电动汽车电池的仿生热安全策略：从生物学原理到工程方法。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-28 DOI: 10.1002/advs.202505882

Weifeng Li, Zhongchun Wang, Yao Xue, Zhenhai Gao, Huanli Sun, Ximin Zhai, Deping Wang, Yupeng Chen

{"title":"Biomimetic Thermal Safety Strategies in Batteries for Electric Vehicles: from Biological Principles to Engineering Approaches.","authors":"Weifeng Li, Zhongchun Wang, Yao Xue, Zhenhai Gao, Huanli Sun, Ximin Zhai, Deping Wang, Yupeng Chen","doi":"10.1002/advs.202505882","DOIUrl":"https://doi.org/10.1002/advs.202505882","url":null,"abstract":"With the rapid development of renewable energy and the widespread adoption of electric vehicles, thermal runaway (TR) in batteries has become a critical safety concern. Despite various protective technologies, TR remains frequent due to challenges in metal dendrite growth, material stability, and efficient thermal management. Inspired by natural structures and functions, biological principles have been abstracted to guide novel biomimetic approaches. This review focuses on TR mechanisms, summarizes the corresponding biomimetic principles, and discusses their applications in functional design strategies to enhance battery safety and stability. First, the review outlines current TR protection designs from both intrinsic and system safety perspectives, analyzing biomimetic strategies to enhance intrinsic safety by improving the thermal stability of battery components to reduce the risk of TR. Next, it explores the application of biomimetic designs in thermal management and protection mechanisms, including innovations in thermal management and structure. Finally, this review consolidates the findings from the preceding sections on biomimetic designs for TR protection, emphasizing current challenges and potential future directions, to offer new technical insights and guidance for research on thermal safety in batteries.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05882"},"PeriodicalIF":14.1,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STEMDiff: A Wavelet-Enhanced Diffusion Model for Physics-Informed STEM Image Generation. STEMDiff：用于物理信息STEM图像生成的小波增强扩散模型。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-27 DOI: 10.1002/advs.202508266

Yihui Bao, Xinyi Lu, Yanyan Xia, Zhencheng Ye, Houyang Chen

{"title":"STEMDiff: A Wavelet-Enhanced Diffusion Model for Physics-Informed STEM Image Generation.","authors":"Yihui Bao, Xinyi Lu, Yanyan Xia, Zhencheng Ye, Houyang Chen","doi":"10.1002/advs.202508266","DOIUrl":"https://doi.org/10.1002/advs.202508266","url":null,"abstract":"Machine learning has emerged as a powerful tool for analyzing scanning transmission electron microscopy (STEM) images, yet its widespread application remains constrained by the scarcity of annotated training data. While deep generative models offer a promising solution, they typically struggle to reproduce the complex high-frequency components that define experimental STEM images. Here, STEMDiff, a conditional diffusion model that transforms simple binary labels derived from crystal structures into realistic STEM images through a physical information embedding strategy, is proposed. By developing a novel Discrete Wavelet Transform-based skip-connection architecture, the high-frequency bias inherent in diffusion models are addressed, enabling the preservation of experimental noise characteristics. This approach generates images that are quantitatively nearly indistinguishable from experimental data (17 fold improvement over previous methods) while retaining ground truth structural information. Fully convolutional networks trained exclusively on these synthetic images achieve high-precision atomic column detection in experimental STEM images of WSe2 and graphene, despite the presence of substantial background noise and contamination. This approach effectively eliminates the need for laborious manual annotation, providing a scalable solution to the data bottleneck in STEM image analysis. The principles underlying STEMDiff can extend to other scientific imaging modalities, accelerating advancements in materials design for water treatment.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08266"},"PeriodicalIF":14.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acidogenesis-Propelled Coordination Transition in Light-Triggered Fe-Polyphenol Polymer for Reactive Oxygen Species-Augmented Antitumor Therapy. 光触发铁-多酚聚合物中酸发生推动的配位转变用于活性氧增强抗肿瘤治疗。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-27 DOI: 10.1002/advs.202513361

Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang, Lu An

{"title":"Acidogenesis-Propelled Coordination Transition in Light-Triggered Fe-Polyphenol Polymer for Reactive Oxygen Species-Augmented Antitumor Therapy.","authors":"Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang, Lu An","doi":"10.1002/advs.202513361","DOIUrl":"https://doi.org/10.1002/advs.202513361","url":null,"abstract":"Iron-based Fenton agents have emerged as promising candidates for tumor therapy due to its excellent selectivity, yet their therapeutic potential is substantially constrained by inefficient Fe3+/Fe2+ conversion in the tumor microenvironment. Herein, based on a coordination engineering strategy, a light-responsive Fe-polyphenol coordination polymer (FeBPs), integrating Fe centers, Bodipy-based photoacid generators, and PEG-stabilized polyphenol ligands, is designed to explore how to accelerate the transformation efficiency of Fe3+ to Fe2+ by incorporating both internal and external factors. In terms of internal factors, upon irradiation at 630 nm, the FeBPs trigger the exposure of catalytic sites derived from the coordination transition nature of iron and polyphenol, induced by light-triggered acidification. Additionally, the Fe2+ regeneration efficiency is also enhanced by changes in the external environment, such as a decrease in pH. Both the light triggered internal and external factors can amplify reactive oxygen species (ROS) fluxes, which disrupt mitochondrial function and induce cell apoptosis, achieving tumor-specific homeostasis perturbation. In melanoma-bearing mouse models, FeBPs exhibit complete tumor regression. The findings establish a paradigm for iron-based therapeutics by harnessing acid-triggered metal-ligand cooperativity, overcoming critical limitations of pH dependency and inefficient Fe3+/Fe2+ conversion, and will provide a foundational framework for adaptive metallopolymeric theranostics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e13361"},"PeriodicalIF":14.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parabiosis, Assembloids, Organoids (PAO). )，是一种有机体（Organoids， OAP）。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-27 DOI: 10.1002/advs.202511671

Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang

{"title":"Parabiosis, Assembloids, Organoids (PAO).","authors":"Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang","doi":"10.1002/advs.202511671","DOIUrl":"https://doi.org/10.1002/advs.202511671","url":null,"abstract":"The research and treatment of major diseases challenge global public health, necessitating advanced disease models. Existing approaches have clear limitations: two-dimensional cell cultures lack multi-organ interactions, clinical trials are costly and ethically constrained, and animal models, focused on single organs, fail to replicate systemic regulation. Parabiosis, which connects two organisms via shared circulation, provides insights into systemic factors and multi-organ interactions but has limited applicability to humans. Furthermore, organoids are three-dimensional structures formed through stem cell self-organization that replicate the functions of individual tissues and advance personalized medicine; however, they cannot model inter-tissue interactions. Assembloids overcome these constraints by integrating diverse organoids, enabling sophisticated simulation of multi-organ dynamics. The integration of these parabiosis, assembloids, organoids (PAO) models with emerging technologies, such as artificial intelligence for precision analytics, CRISPR-based gene editing for disease mechanism elucidation, organ-on-a-chip platforms for dynamic environmental control, and soft robotics for replicating physiological biomechanics, promises to revolutionize disease modeling, regenerative medicine, and precision therapeutics. This review evaluates parabiosis, assembloids, and organoids, highlighting their development, current limitations, and transformative potential when combined with frontier biomedical engineering approaches to address complex human diseases.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e11671"},"PeriodicalIF":14.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adamts1 Exacerbates Post-Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8. Adamts1通过整合素α8的机械传感加剧心肌梗死后疤痕形成。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-27 DOI: 10.1002/advs.202504138

Chun-Yan Kong, Zhen Guo, Yu-Lan Ma, Ming-Yu Wang, Hai-Yang Ni, Pan Wang, Wen-Jun Qiu, En-Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi-Zhu Tang

{"title":"Adamts1 Exacerbates Post-Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8.","authors":"Chun-Yan Kong, Zhen Guo, Yu-Lan Ma, Ming-Yu Wang, Hai-Yang Ni, Pan Wang, Wen-Jun Qiu, En-Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi-Zhu Tang","doi":"10.1002/advs.202504138","DOIUrl":"https://doi.org/10.1002/advs.202504138","url":null,"abstract":"-Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with post-infarction cardiac remodeling, particularly excessive scar formation, representing a critical determinant of patient outcomes. However, the mechanistic pathways governing pathological scar formation remain incompletely understood. Here, we demonstrate that ADAMTS1 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1), significantly upregulated in endothelial cells (ECs) following MI, plays a pivotal role in regulating cardiac fibroblast activation through a novel mechanotransduction pathway involving integrin α8 (ITGα8). Using EC-specific ADAMTS1 overexpression and knockout mice combined with cardiac fibroblast-specific ITGα8 deletion models, we found that ADAMTS1 overexpression exacerbates cardiac dysfunction and increases scar size, while ADAMTS1 deficiency provides cardioprotection. Mechanistically, ADAMTS1 modulates extracellular matrix stiffness through proteoglycan (PG) cleavage rather than direct protein interactions, which activates ITGα8 mechanosensing specifically in cardiac fibroblasts. Among integrin family members tested, ITGα8 shows selective responsiveness to ADAMTS1-mediated mechanical cues, as confirmed by tunable-stiffness hydrogel experiments and validated through comprehensive proteomic and functional analyses. ITGα8 deficiency rescues ADAMTS1-induced cardiac dysfunction and reduces pathological scar formation. These findings reveal a previously unrecognized ADAMTS1-ITGα8 mechanotransduction pathway, representing a promising therapeutic target for optimizing post-infarction cardiac remodeling.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04138"},"PeriodicalIF":14.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Functional 3D Colon Model for the Induction and Monitoring of Diseases. 用于诱导和监测疾病的功能性3D结肠模型的开发。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-27 DOI: 10.1002/advs.202506377

Jorge Alfonso Tavares-Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour

{"title":"Development of a Functional 3D Colon Model for the Induction and Monitoring of Diseases.","authors":"Jorge Alfonso Tavares-Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour","doi":"10.1002/advs.202506377","DOIUrl":"https://doi.org/10.1002/advs.202506377","url":null,"abstract":"Conventional in vitro and animal models do not reproduce the geometry, mechanics, or transport physics of the human colon, limiting their fidelity for disease studies and drug screening. A patient-derived, freeform reversible embedding of suspended hydrogels bioprinted three-dimensional (3D) in vivo mimicking human-colon model (3D-IVM-HC) is reported whose micro-computed tomography (CT) profile deviates by less than 4% from the original computed tomography template and spontaneously forms crypt-like invaginations with a median depth of 65 µm. The dual-layer gelatin methacrylate (GelMA)/alginate matrix matches native colonic stiffness (9-65 kPa) and sustains >95% cell viability with a 14-fold metabolic increase over 14 days. Caco-2 epithelia polarize within the lumen, form continuous Zonula occludens-1 (ZO-1) belts, and reach a transepithelial electrical resistance (TEER) of 68 ± 4 Ω cm2, values within the human ex vivo range. Finite-element simulations (FEM) parameterized with measured geometry and resistance predict water and nutrient fluxes within 80-99% of human explants. When HCT116 tumor spheroids are introduced, the construct yields a 5-fluorouracil (5-FU) half-maximal inhibitory concentration (IC5₀) of 540 ± 30 µm, an order of magnitude higher than a matched two-dimensional (2D) monolayer (42 ± 5 µm), mirroring clinical chemoresistance. Together, these benchmarks establish the 3D-IVM-HC as a physiologically faithful, animal-free platform for probing colorectal biology and quantifying drug response.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06377"},"PeriodicalIF":14.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury. 自体类器官- t细胞共培养平台构建免疫介导药物性肝损伤模型。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-26 DOI: 10.1002/advs.202508584

Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra

{"title":"Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury.","authors":"Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra","doi":"10.1002/advs.202508584","DOIUrl":"https://doi.org/10.1002/advs.202508584","url":null,"abstract":"Modeling adaptive immune responses in induced pluripotent stem cell (iPSC)-derived liver systems remains a critical barrier for studying immune-mediated hepatic diseases, including idiosyncratic drug-induced liver injury (iDILI). Conventional hepatotoxicity models lack the components required to capture patient-specific, T cell-mediated injury. Here, a scalable and matrix-free human liver organoid (HLO) microarray platform is presented that enables controlled co-culture of Human Leukocyte Antigen (HLA)-genotyped, iPSC-derived HLOs with autologous CD8⁺ T cells. This immune-competent system supports antigen-specific T cell activation and reproduces cytotoxic effector responses in a genetically defined context. As a proof-of-concept, the platform models clinically relevant iDILI caused by flucloxacillin in HLA-B*57:01 carriers, recapitulating CD8⁺ T cell proliferation, hepatocyte apoptosis, and variability in immune responses across donors. The system captures hallmark features of adaptive immune-mediated hepatotoxicity, including secretion of tumor necrosis factor-alpha and Granzyme B, and cytokeratin-18 release from injured hepatocytes. By linking genetic susceptibility with functional immune outcomes, this platform provides a modular and scalable approach for evaluating immune-mediated toxicities. The method offers broad utility for mechanistic studies of drug hypersensitivity, immune-related adverse events, and preclinical safety assessment in support of precision medicine.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08584"},"PeriodicalIF":14.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Optoelectronic Reconfigurable Transistors Based on Graphene/VO₂ Heterojunction for Efficient Neuromorphic Perception, Computation, and Storage. 基于石墨烯/VO2异质结的新型光电可重构晶体管，用于高效的神经形态感知、计算和存储。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-26 DOI: 10.1002/advs.202513429

Danke Chen, Yuning Li, Xiaoqiu Tang, Jingye Sun, Xuan Yao, Peizhi Yu, Xue Li, Qing You, Hanyu Wang, He Tian, Tao Deng

{"title":"Novel Optoelectronic Reconfigurable Transistors Based on Graphene/VO2 Heterojunction for Efficient Neuromorphic Perception, Computation, and Storage.","authors":"Danke Chen, Yuning Li, Xiaoqiu Tang, Jingye Sun, Xuan Yao, Peizhi Yu, Xue Li, Qing You, Hanyu Wang, He Tian, Tao Deng","doi":"10.1002/advs.202513429","DOIUrl":"https://doi.org/10.1002/advs.202513429","url":null,"abstract":"Optoelectronic artificial neuromorphic devices, inspired by biological vision systems, have overcome bottlenecks of the von Neumann architecture. The innovation and integration of neuromorphic hardware systems represent a pivotal challenge for advancing the iteration of artificial intelligence. Accordingly, a novel optoelectronic reconfigurable neuromorphic transistor (ORNT) is designed to integrate three functions, enabling the perception, computation, and storage of optical information in a manner analogous to visual nervous systems. Based on the electrode-inserted graphene/VO2 nanoparticles heterostructure and photovoltaic effect, the ORNT demonstrates broadband self-powered responsiveness from the ultraviolet to near-infrared (365-940 nm). Leveraging the photogating effect and the photoinduced phase transition in VO2, the differentiated electrode design enables wide-electrode ORNTs to exhibit synaptic behavior under bias voltages, whereas narrow-electrode ORNTs demonstrate data storage capability and multistage photomodulation. Furthermore, an integrated optical communication and processing-in-memory system is developed, achieving a full-process demonstration from optical perception to computation and storage. Overall, the ORNTs introduced in this work provide an innovative strategy for optimizing the hardware resource allocation of chips and enhancing the adaptability and scalability of systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e13429"},"PeriodicalIF":14.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoregulatory Roles of Tumor-Originated Pericytes Identified by Single-Cell Analysis in Glioblastoma. 胶质母细胞瘤单细胞分析鉴定肿瘤源性周细胞的免疫调节作用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-26 DOI: 10.1002/advs.202511856

Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu-Wu Bian, Hai-Bo Wu, Aili Zhang, Wenchao Zhou

{"title":"Immunoregulatory Roles of Tumor-Originated Pericytes Identified by Single-Cell Analysis in Glioblastoma.","authors":"Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu-Wu Bian, Hai-Bo Wu, Aili Zhang, Wenchao Zhou","doi":"10.1002/advs.202511856","DOIUrl":"https://doi.org/10.1002/advs.202511856","url":null,"abstract":"Pericytes as critical vascular support cells not only keep the integrity of blood-brain barrier but also play profound roles in brain tumors. Yet the origin and functional heterogeneity of pericytes in the most common malignant brain tumor glioblastoma (GBM) remain unclear. Here, single-cell RNA-sequencing (scRNA-seq) is performed on CD146+ pericytes from human primary GBMs. Tumor- and normal-originated pericytes (T-PCs and N-PCs) that have distinctive cell-intrinsic features and intercellular communications with endothelial and immune cells are identified. Bioinformatic analyses on integrated in-house and public scRNA-seq data have found a T-PC metacluster marked by CD44 closely associated with tumor-associated macrophages (TAMs). The CD44High pericytes are detected in human GBM samples and glioma-stem-cell (GSC)-derived pericytes. Coimplantation of GSC-derived CD44High pericytes promotes M2 polarization of TAMs and growth of orthotopic GBMs. In summary, this study unravels the existence of T-PCs and N-PCs in GBMs, analyzes their functional heterogeneity, and unravels the immunoregulatory roles of CD44High pericytes. These discoveries help to gain insights into brain tumor vasculature and inspire therapeutic strategies targeting vessels and TAMs for GBM treatment.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e11856"},"PeriodicalIF":14.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Carbon Dots for Electrochemical Capacitors Reviewed: Their Opportunities and Challenges. 电化学电容器用多功能碳点：机遇与挑战

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-09-26 DOI: 10.1002/advs.202508000

Naiyun Liu, Jingwen Yu, Yaxi Li, Yunliang Liu, Sobia Jabeen, Yuanyuan Cheng, Lei Zhou, Dmitri L Danilov, Peter H L Notten, Haitao Li

{"title":"Multifunctional Carbon Dots for Electrochemical Capacitors Reviewed: Their Opportunities and Challenges.","authors":"Naiyun Liu, Jingwen Yu, Yaxi Li, Yunliang Liu, Sobia Jabeen, Yuanyuan Cheng, Lei Zhou, Dmitri L Danilov, Peter H L Notten, Haitao Li","doi":"10.1002/advs.202508000","DOIUrl":"https://doi.org/10.1002/advs.202508000","url":null,"abstract":"Electrochemical capacitors (ECs) are promising energy storage devices due to their rapid charge/discharge capability. However, they face limitations in energy density, and certain capacitor materials may exhibit poor conductivity and structural instability. Carbon dots (CDs), characterized by their small size, abundant surface functional groups, and controllable properties, show great potential in enhancing the performance of ECs. This review presents the challenges and opportunities associated with multifunctional CDs in ECs. It begins by summarizing the classification and basic working principles of ECs. Next, it discusses in detail the synthesis methods, fundamental physical and chemical properties, and the electrochemical and photoelectrochemical properties of CDs. Subsequently, it explores the application of CDs as electrode additives and electrolyte additives in ECs, highlighting their unique benefits in improving capacitor performance. Additionally, it examines the innovative use of CDs in photo-assisted capacitors, revealing insights into capacitor technology derived from the synergistic effects of light and electrochemical energy storage processes. Finally, the current challenges facing the applications for CD-based ECs are discussed, followed by proposing future research opportunities. This review emphasizes the significant role of multifunctional CDs and their promising potential in advancing EC technology.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08000"},"PeriodicalIF":14.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0