Advanced Science最新文献_第10页

Accurate and Noninvasive Dysphagia Assessment via a Soft High-Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202500472

Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobin Chen

{"title":"Accurate and Noninvasive Dysphagia Assessment via a Soft High-Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles.","authors":"Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobin Chen","doi":"10.1002/advs.202500472","DOIUrl":"https://doi.org/10.1002/advs.202500472","url":null,"abstract":"Accurate, noninvasive dysphagia assessment is important for rehabilitation therapy but current clinical diagnostic methods are either invasive or subjective. Surface electromyography (sEMG) that monitors muscle activity during swallowing, offers a promising alternative. However, existing sEMG electrode arrays for dysphagia assessment remain challenging in combining the advantages of a large coverage area and strong compliance to the entire swallowing muscles. Here, we report a stretchable, breathable, large-area high-density sEMG (HD-sEMG) electrode array, which enables intimate contact to complex surface of the submental and infrahyoid muscles to detect high-fidelity HD-sEMG signals during swallowing. The electrode array features a 64-channel soft on-skin sensing array for comprehensive data capture, and a stiff connector for simple and reliable connection to an external acquisition setup. Systemically experimental studies revealed the easy operability of the soft HD-sEMG electrode array for effortless integration with the skin, as well as the excellent mechanical and electrical characteristics even subject to substantial skin deformations. By comparing HD-sEMG signals collected from 38 participants, three objective indicators for quantitative dysphagia evaluation were discussed. Finally, a machine learning model was developed to accurately and automatically classify the severity of dysphagia, and the factors affecting the recognition accuracy of the model were discussed in depth.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500472"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupylation-Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202414496

Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson

{"title":"Pupylation-Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex.","authors":"Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson","doi":"10.1002/advs.202414496","DOIUrl":"https://doi.org/10.1002/advs.202414496","url":null,"abstract":"Target of rapamycin (TOR) is a signaling hub that integrates developmental, hormonal, and environmental signals to optimize carbon allocation and plant growth. In plant cells, TOR acts together with the proteins LST8-1 and RAPTOR1 to form a core TOR complex (TORC). While these proteins comprise a functional TORC, they engage with many other proteins to ensure precise signal outputs. Although TORC interactions have attracted significant attention in the recent past, large parts of the interactome are still unknown. In this resource study, PUP-IT is adapted, a fully endogenously expressed protein proximity labeling toolbox, to map TORC protein-protein interactions using the core set of TORC as baits. It is outlined how this interactome is differentially phosphorylated during changes in carbon availability, uncovering putative direct TOR kinase targets. An AlphaFold-Multimer approach is further used to validate many interactors, thus outlining a comprehensive TORC interactome that includes over a hundred new candidate interactors and provides an invaluable resource to the plant cell signaling community.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414496"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symmetrical Triboelectric In Situ Self-Powered Sensing and Fault Diagnosis for Double-Row Tapered Roller Bearings in Wind Turbines: An Integrated and Real-Time Approach.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202500981

Song Wang, Xiantao Zhang, Tenghao Ma, Yun Kong, Shuai Gao, Qinkai Han

{"title":"Symmetrical Triboelectric In Situ Self-Powered Sensing and Fault Diagnosis for Double-Row Tapered Roller Bearings in Wind Turbines: An Integrated and Real-Time Approach.","authors":"Song Wang, Xiantao Zhang, Tenghao Ma, Yun Kong, Shuai Gao, Qinkai Han","doi":"10.1002/advs.202500981","DOIUrl":"https://doi.org/10.1002/advs.202500981","url":null,"abstract":"Double-row tapered roller bearings (DTRBs) are widely used in wind turbines because of their high load-bearing capacity and durability. However, wind turbines typically operate in harsh environments, subjecting bearings to complex working conditions, which significantly increases the difficulty of operational status monitoring. Traditional monitoring methods rely on external power sources and complex sensor networks, which make them susceptible to environmental interference, and complicated to maintain. This paper presents an innovative, integrated symmetrical single-electrode triboelectric double-row tapered roller bearing (SST-DTRB) by incorporating a triboelectric nanogenerator (TENG) with DTRB. This scheme converts the frictional energy generated during bearing operation into electrical output, producing signals that enable simultaneous sensing of both ends of DTRB. Experimental results demonstrate that this monitoring scheme exhibits high sensitivity, stability, and reliability, with excellent robustness in material selection and design gap, and is capable of long-term operation without external power sources. The effectiveness and self-sensing capability of SST-DTRB under variable speeds are validated using a wind turbine test bench. High-accuracy bearing fault diagnosis under multiple conditions is achieved based on time-frequency transformation and deep residual neural networks. The proposed SST-DTRB provides in situ self-powered sensing capability for wind turbines and offers new insights in the development of intelligent sensing systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500981"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202407575

Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu

{"title":"Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.","authors":"Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu","doi":"10.1002/advs.202407575","DOIUrl":"https://doi.org/10.1002/advs.202407575","url":null,"abstract":"The immune evasion is one major challenge for cancer immunotherapy. Despite considerable advancements in immune checkpoint blockade (ICB) therapies for the advanced non-small cell lung cancer (NSCLC) patients, only a minority of patients receive long-term survival benefit. Here, this work demonstrates that lysine methyltransferase 5C (KMT5C) is a crucial promoter of the NSCLC progression and immune evasion. This work first observes that upregulation of KMT5C in NSCLC correlated with cancer progression and poor patient prognosis. Notably, KMT5C knockdown in NSCLC cells suppress tumor growth and metastasis in mice. Mechanistically, this work demonstrates that KMT5C activated the DNA repair response to inhibit the STING-IRF3 pathway, downstream type I IFN signaling, and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor immune evasion and tumor progression. Importantly, both the pharmacological inhibitor A196 and the genetic inhibition of KMT5C could synergize with anti-PD-1 therapy in the lung cancer mouse model. Clinically, high expression levels of KMT5C in patients with NSCLC are associated with a lower response rate and worse clinical outcomes to ICB therapy. Therefore, these findings identify a previously unknown functional link between KMT5C and tumor immune evasion, and demonstrate that targeting KMT5C may be a potential therapeutic approach for enhancing the efficacy of NSCLC patients to ICB therapy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2407575"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competitive Anion Anchoring and Hydrogen Bonding in Multiscale-Coupling Composite Quasi-Solid Electrolytes for Fire-Safety and Long-Life Lithium Metal Batteries.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202501012

Ding Hu, Guo-Rui Zhu, Ping-Hui Duan, Si-Chong Chen, Gang Wu, Yu-Zhong Wang

{"title":"Competitive Anion Anchoring and Hydrogen Bonding in Multiscale-Coupling Composite Quasi-Solid Electrolytes for Fire-Safety and Long-Life Lithium Metal Batteries.","authors":"Ding Hu, Guo-Rui Zhu, Ping-Hui Duan, Si-Chong Chen, Gang Wu, Yu-Zhong Wang","doi":"10.1002/advs.202501012","DOIUrl":"https://doi.org/10.1002/advs.202501012","url":null,"abstract":"Composite solid-state electrolytes (CSEs) using Li1+xAlxTi2-x(PO4)3 (LATP) as active fillers offer promising prospects for large-scale lithium metal batteries (LMBs) applications due to their high environmental stability, cost-effectiveness, and improved safety. However, the challenges persist owing to high interfacial resistance with electrodes and instability with lithium metal. Herein, self-assembly nanofiber/polymers/LATP composite quasi-solid electrolytes (SL-CQSEs) are reported through in situ polymerization of precursor solution containing vinylene carbonate (VC), fluoroethylene carbonate (FEC), lithium bis(trifluoromethanesulfonic) imide (LiTFSI) in a porous and flexible self-supporting skeleton (SSK) consisting of 2-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)ethyl methacrylate (UPyMA)'s self-assembly nanofiber (SAF), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and LATP. Anion-anchoring/hydrogen-bonding competition and intercomponent multiscale-coupling effects on SL-CQSEs are found, which contribute to their incombustibility, excellent room-temperature ionic conductivity (1.03 mS cm-1), wide electrochemical window (5.1 V), good interfacial compatibility, and lasting inhibition of lithium dendrites. LiFePO4/Li cells with SL-CQSEs not only exhibit high-rate performance and long-term cycling stability, with a capacity retention of 90.4% at 1C and 87% even at 4C after 1000 cycles, but also can resist fire and mechanical abuse, highlighting the potential applications of SL-CQSEs for high-performance and safety LMBs.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2501012"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cation-Anchoring-Induced Efficient n-Type Thermo-Electric Ionogel with Ultra-High Thermopower.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202414389

Wenchao Zhen, Chengshuai Lu, Duo Li, Guangfan Meng, Hongqin Wang, Yifei Jiang, Jiang Lou, Wenjia Han

{"title":"Cation-Anchoring-Induced Efficient n-Type Thermo-Electric Ionogel with Ultra-High Thermopower.","authors":"Wenchao Zhen, Chengshuai Lu, Duo Li, Guangfan Meng, Hongqin Wang, Yifei Jiang, Jiang Lou, Wenjia Han","doi":"10.1002/advs.202414389","DOIUrl":"https://doi.org/10.1002/advs.202414389","url":null,"abstract":"Ionogels have emerged as promising candidates for low-grade thermal energy harvesting due to their leak-free electrolytes, exceptional flexibility, thermal stability, and high thermopower. While substantial progress in the thermoelectric performance of p-type ionogels, research on n-type ionic materials lags behind. Striking a harmonious balance between high mechanical performance and thermoelectric properties remains a formidable challenge. This work presents an advanced n-type ionogel system integrating polyethylene glycol diacrylate (PEGDA), hydroxyethyl methacrylate (HEMA), 1-allyl-3-methylimidazolium chloride ([AMIM]Cl), and bacterial cellulose (BC) through a rational design strategy. The synergistic combination of photo-polymerization and hydrogen-bonding networks effectively immobilizes imidazolium cations while enabling rapid chloride ion transport, creating a pronounced cation-anion mobility disparity that yields a substantial negative ionic Seebeck coefficient of -7.16 mV K⁻¹. Furthermore, BC's abundant hydroxyl groups establish multivalent hydrogen bonds within the ternary polymer matrix, endowing the composite with exceptional mechanical properties-notably a tensile strength of 3.2 MPa and toughness of 4.1 MJ m⁻3. Moreover, the ionogel exhibits sensitive responses to stimuli such as pressure, strain, and temperature. The thermoelectric modules fabricated can harness body heat to illuminate a bulb, showcasing great potential for low-grade energy harvesting and ultra-sensitive sensing.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414389"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ISG15 Enhances the Activity of γ-Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet-Promoted Hepatocellular Carcinoma.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202416401

Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng

{"title":"ISG15 Enhances the Activity of γ-Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet-Promoted Hepatocellular Carcinoma.","authors":"Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng","doi":"10.1002/advs.202416401","DOIUrl":"https://doi.org/10.1002/advs.202416401","url":null,"abstract":"Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High-fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level and escape the cytotoxic effects of high fat diet (HFD) stress remains unclear. Herein, this work reports a critical anti-ROS/apoptotic role of the ubiquitin-like protein interferon stimulated gene 15 (ISG15) in HFD-promoted HCC. In mouse models and clinical HCC samples, upregulation of ISG15 is associated with hepatic steatosis. Notably, upregulated ISG15 elevates cellular glutathione levels, which subsequently reduces ROS accumulation and confers resistance to apoptosis in HCC cells. In diethylnitrosamine-induced HCC mouse model, HFD-feeding promotes HCC progression in wildtype mice, while tumor growth is significantly suppressed accompanied by apoptosis of HCC cells in Isg15-KO mice. Mechanistically, ISG15 promotes the activity of γ-glutamate cysteine ligase (γ-GCL), a rate-limiting heterodimeric holoenzyme of glutathione synthesis consisting of glutamate-cysteine ligase catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM). Independent of ISGylation, ISG15 forms an ISG15/GCLM/GCLC complex that promotes GCLM-GCLC interaction, increases glutathione generation and inhibits HFD-induced apoptosis in HCC cells. Together, an anti-apoptotic ISG15-γ-GCL-glutothione axis is suggested in HFD-promoted HCC.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416401"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD-1 Blockade in MSS Colorectal Cancer.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202501623

Qi-Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang

{"title":"Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD-1 Blockade in MSS Colorectal Cancer.","authors":"Qi-Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang","doi":"10.1002/advs.202501623","DOIUrl":"https://doi.org/10.1002/advs.202501623","url":null,"abstract":"Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored. Here it is demonstrated that methionine restriction inhibits the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of cholesterol homeostasis and a potential target for cancer immunotherapy, in colorectal cancer (CRC) but not in the liver. Mechanistically, methionine is catabolized to S-adenosylmethionine (SAM), promoting mRNA transcription of PCSK9 through increased DNA methyltransferase 1 (DNMT1)-mediated DNA methylation and suppression of sirtuin 6 (SIRT6) expression. Furthermore, both PCSK9 inhibition and dietary methionine restriction (DMR) potentiate PD-1 blockade therapy and foster the infiltration of CD8+ T cells in Colon 26 tumor-bearing mice-a proficient mismatch repair (pMMR)/microsatellite stable (MSS) CRC model that exhibits limited response to anti-PD-1 therapy. Moreover, combining 5-fluorouracil (5-FU) chemotherapy with PCSK9 inhibition and PD-1 blockade further augments therapeutic efficacy for MSS CRC. The findings establish a mechanistic link between amino acid metabolism and cholesterol metabolism within the tumor microenvironment where tumor cells sense methionine to regulate PCSK9 expression, highlighting promising combination therapeutic strategies that may greatly benefit MSS CRC patients.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2501623"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Absorbent Ultrafast Self-Gelling Starch Microparticles for Robust Wet-Tissue Adhesion and Instant Hemostasis.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202501857

Soohwan An, Jihoon Jeon, Seung Yeop Han, Mi Jeong Lee, Tae-Gyeong Oh, Eun Je Jeon, Dong Jin Joo, Seung-Woo Cho

{"title":"Highly Absorbent Ultrafast Self-Gelling Starch Microparticles for Robust Wet-Tissue Adhesion and Instant Hemostasis.","authors":"Soohwan An, Jihoon Jeon, Seung Yeop Han, Mi Jeong Lee, Tae-Gyeong Oh, Eun Je Jeon, Dong Jin Joo, Seung-Woo Cho","doi":"10.1002/advs.202501857","DOIUrl":"https://doi.org/10.1002/advs.202501857","url":null,"abstract":"Rapid and effective hemostasis of mass bleeding from irregularly shaped wounds remains a critical clinical challenge. Herein, a highly absorbent and self-gelling microparticle (MP) is reported based on modified starch as a hemostatic material with robust wet tissue adhesiveness. The aldehyde- and catechol-modified starch (ACS) is synthesized via partial oxidation of starch for the reduction of dense intermolecular interactions within starch, thereby significantly enhancing its interaction with water molecules. Moreover, the conjugated catechol group strengthens the affinity to various biomolecules. The ACS microparticle (ACS-MP) prepared by calcium intercalation into the polysaccharide chains and subsequent freeze-milling rapidly converts to a stable hydrogel within seconds upon hydration, exhibiting superior water absorption capacity and tissue adhesion. The ACS-MP demonstrates excellent in vivo biocompatibility in local and systemic administration. The application of ACS-MP to bleeding wounds enables rapid blood absorption and accumulation of blood components and coagulation factors. The ACS-MP can fill irregularly shaped wounds, forming a tissue-adhesive hydrogel in situ, thereby creating a physical barrier for non-compressible hemostasis. The superior hemostatic performance of ACS-MP against massive hemorrhage from liver injuries in mice and pigs is confirmed. The ACS-MP will be a promising hemostat for effectively controlling mass bleeding in various tissues in clinical settings.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2501857"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Testosterone Signaling in Microglia: A Potential Role for Sex-Related Differences in Alzheimer's Disease.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-03-24 DOI: 10.1002/advs.202413375

Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu

{"title":"Role of Testosterone Signaling in Microglia: A Potential Role for Sex-Related Differences in Alzheimer's Disease.","authors":"Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu","doi":"10.1002/advs.202413375","DOIUrl":"https://doi.org/10.1002/advs.202413375","url":null,"abstract":"Alzheimer's disease (AD) is less prevalent in men than in women, although mechanisms remain unclear. Microglia degrade aggregated amyloid β (Aβ) through the lysosomal system, including autophagy. G protein-coupled receptor family C group 6 member A (GPRC6A), predominantly expressed in mouse microglial MG6 cells, is a primary mediator of testosterone signaling. This study examines testosterone's role in modulating Aβ-induced autophagy in microglia. Testosterone promotes Aβ-induced autophagy leading to Aβ clearance in MG6 cells by suppressing extracellular signal-regulated kinase (ERK) phosphorylation and subsequently inhibiting mammalian target of rapamycin (mTOR) activation, which is abrogated by shRNA knockdown of GPRC6A. In in vivo experiments with male 5xFAD AD model mice, Aβ clearance activity is associated with autophagy in microglia and is reduced by orchiectomy, but restored by testosterone supplementation. ERK phosphorylation in the brains of male AD model mice is upregulated by orchiectomy. Therefore, testosterone is involved in autophagy-mediated Aβ clearance in microglia. Aβ accumulation in human brain samples from patients with AD is significantly lower in men than in women, with less pronounced colocalization of Aβ with p62 aggregates, suggesting enhanced autophagic activity in men. In conclusion, testosterone enhances Aβ-induced autophagy in microglia, possibly contributing to lower susceptibility to AD in men.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413375"},"PeriodicalIF":14.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0