Advanced Science最新文献_第10页

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202411540

Long Zhao, Zhen Shi, Xiaoyu Zhang, Jingting Wang, Shang Yang, Fuyan Wang, Tan Li, Qingjun Zhou, Ting Wang, Weiyun Shi

{"title":"Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation.","authors":"Long Zhao, Zhen Shi, Xiaoyu Zhang, Jingting Wang, Shang Yang, Fuyan Wang, Tan Li, Qingjun Zhou, Ting Wang, Weiyun Shi","doi":"10.1002/advs.202411540","DOIUrl":"https://doi.org/10.1002/advs.202411540","url":null,"abstract":"Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma-like adhesive patches (HCSPs) are prepared through a multi-step process. First, polyethylene glycol diacrylate is cast and cured within decellularized porcine cornea (DPC) templates. The DPCs are then enzymatically digested to obtain hydrogel skeletons, which are finally integrated with human corneal extracellular matrix and methacrylate gelatin. HCSPs replicate the ultrastructure, protein components, and optical properties of human corneas and exhibit improved anti-swelling and anti-degradation capabilities compared with conventional DPCs and recombinant human collagen patches. HCSPs can deliver methacrylate gelatin at the ocular surface temperature (37 °C) and achieve stable adhesion to the corneal stroma upon 405 nm light irradiation. Furthermore, HCSPs promote the survival and migration of corneal epithelial and stromal cells while preserving their phenotypes. In rabbit models of lamellar keratoplasty and microperforation repair, HCSPs accelerate epithelial healing, minimize suture-associated complications, and maintain structural stability. These findings suggest that HCSPs are promising donor corneal substitutes for clinical applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411540"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Observation of Substantial Phonon Nonequilibrium Near Nanoscale Hotspots in Gallium Nitride.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202411040

Jiaxuan Xu, Xiaona Huang, Yufei Sheng, Qiangsheng Sun, Hongkai Zhang, Hua Bao, Yanan Yue

{"title":"Direct Observation of Substantial Phonon Nonequilibrium Near Nanoscale Hotspots in Gallium Nitride.","authors":"Jiaxuan Xu, Xiaona Huang, Yufei Sheng, Qiangsheng Sun, Hongkai Zhang, Hua Bao, Yanan Yue","doi":"10.1002/advs.202411040","DOIUrl":"https://doi.org/10.1002/advs.202411040","url":null,"abstract":"Phonon modal nonequilibrium is believed to widely exist around nanoscale hotspots, which can significantly affect the performance of nano-electronic and optoelectronic devices. However, such a phenomenon has not been explicitly observed in 3D device semiconductors at the nanoscale. Here, by employing a tip-enhanced Raman thermal measurement approach, substantial phonon nonequilibrium in gallium nitride near sub-10 nm laser-excited hotspots is directly revealed for the first time. As further evidence, quantitative agreements between measurements and accurate first-principles-based phonon Boltzmann transport equation calculations are obtained. The large nonequilibrium is attributed to the strong Fröhlich coupling of electrons with longitudinal optical phonons and the large acoustic-optical phonon frequency gap in gallium nitride, which is further demonstrated in other common III-V semiconductors. This work establishes a viable approach for understanding nanoscale nonequilibrium phonon transport and can potentially benefit the future modulation of hot carrier dynamics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411040"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turning Waste into Treasure: Functionalized Biomass-Derived Carbon Dots for Superselective Visualization and Eradication of Gram-Positive Bacteria.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202411084

Ke-Fei Xu, Zihao Wang, Macheng Cui, Yuhan Jiang, Chengcheng Li, Zi-Xi Wang, Ling-Yi Li, Chenyang Jia, Lijie Zhang, Fu-Gen Wu

{"title":"Turning Waste into Treasure: Functionalized Biomass-Derived Carbon Dots for Superselective Visualization and Eradication of Gram-Positive Bacteria.","authors":"Ke-Fei Xu, Zihao Wang, Macheng Cui, Yuhan Jiang, Chengcheng Li, Zi-Xi Wang, Ling-Yi Li, Chenyang Jia, Lijie Zhang, Fu-Gen Wu","doi":"10.1002/advs.202411084","DOIUrl":"https://doi.org/10.1002/advs.202411084","url":null,"abstract":"Gram-positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin-like residues for precisely targeting Gram-positive bacteria. Subsequently, fluorescein isothiocyanate (FITC) molecules are grafted onto BCDs to yield FITC-labeled BCDs (termed CDFs), which can selectively and rapidly (≤5 min) stain bacterial cell wall and particularly target the peptidoglycan component. Strikingly, CDFs achieve superselective visualization of Gram-positive bacteria even in the presence of mammalian cells and Gram-negative bacteria. Furthermore, protoporphyrin (PpIX) molecules are conjugated onto BCDs to yield PpIX-modified BCDs (termed CDPs), which can induce bacterial aggregation and in situ generate singlet oxygen for realizing enhanced antibacterial photodynamic therapy (PDT). At the minimum bactericidal concentration of CDPs (PpIX: 5 µg mL-1), CDP-mediated PDT disrupts bacterial structure and metabolism pathways, thereby affecting bacterial interactions to eradicate biofilms. Importantly, CDP-mediated PDT efficiently modulates antiinflammatory responses to promote wound healing in the bacteria-infected mice. This study underscores the significance of harnessing renewable and cost-effective biomass resources for preparing Gram-positive bacteria-targeting theranostic agents, which may find potential clinical applications in the future.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411084"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202414141

Jingsheng Yuan, Mingyang Yang, Zhenru Wu, Jun Wu, Kejie Zheng, JiaGuo Wang, Qiwen Zeng, Menglin Chen, Tao Lv, Yujun Shi, Jiayin Yang, Jian Yang

{"title":"The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.","authors":"Jingsheng Yuan, Mingyang Yang, Zhenru Wu, Jun Wu, Kejie Zheng, JiaGuo Wang, Qiwen Zeng, Menglin Chen, Tao Lv, Yujun Shi, Jiayin Yang, Jian Yang","doi":"10.1002/advs.202414141","DOIUrl":"https://doi.org/10.1002/advs.202414141","url":null,"abstract":"Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether hyperlactatemia exacerbates hepatic ischemia-reperfusion injury (IRI) after donor liver implantation remains unclear. Here, the role of hyperlactatemia in hepatic IRI is explored. In this work, hyperlactatemia is found to exacerbate ferroptosis during hepatic IRI. Lactate-primed lysine acetyltransferase 8 (KAT8) is determined to directly lactylate mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2) at Lys100 and augments PCK2 kinase activity. By using gene-edited mice, evidence indicating that PCK2 exacerbates hepatic ferroptosis during IRI is generated. Mechanistically, PCK2 lactylate at Lys100 acts as a critical inducer of ferroptosis during IRI by competitively inhibiting the Parkin-mediated polyubiquitination of 3-oxoacyl-ACP synthase (OXSM), thereby leading to metabolic remodeling of mitochondrial fatty acid synthesis (mtFAS) and the potentiation of oxidative phosphorylation and the tricarboxylic acid cycle. More importantly, targeting PCK2 is demonstrated to markedly ameliorate hyperlactatemia-mediated ferroptosis during hepatic IRI. Collectively, the findings support the use of therapeutics targeting PCK2 to suppress hepatic ferroptosis and IRI in patients with hyperlactatemia during LT.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414141"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Synaptic Memristors With Controlled Rigidity in Zirconium-Oxo Clusters for High-Precision Neuromorphic Computing.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202412289

Jae-Hyeok Cho, Suk Yeop Chun, Ga Hye Kim, Panithan Sriboriboon, Sanghee Han, Seung Beom Shin, Jeehoon Kim, San Nam, Yunseok Kim, Yong-Hoon Kim, Jung Ho Yoon, Myung-Gil Kim

{"title":"Flexible Synaptic Memristors With Controlled Rigidity in Zirconium-Oxo Clusters for High-Precision Neuromorphic Computing.","authors":"Jae-Hyeok Cho, Suk Yeop Chun, Ga Hye Kim, Panithan Sriboriboon, Sanghee Han, Seung Beom Shin, Jeehoon Kim, San Nam, Yunseok Kim, Yong-Hoon Kim, Jung Ho Yoon, Myung-Gil Kim","doi":"10.1002/advs.202412289","DOIUrl":"https://doi.org/10.1002/advs.202412289","url":null,"abstract":"Flexible memristors are promising candidates for multifunctional neuromorphic computing applications, overcoming the limitations of conventional computing devices. However, unpredictable switching behavior and poor mechanical stability in conventional memristors present significant challenges to achieving device reliability. Here, a reliable and flexible memristor using zirconium-oxo cluster (Zr6O4OH4(OMc)12) as the resistive switching layer is demonstrated. The optimization of the structural rigidity of the hybrid oxo-cluster network by thermal polymerization allows the precise formation of dispersed conductive cluster networks, enhancing the repeatability of the resistive switching with mechanical flexibility. The optimized memristor exhibits endurance of ∼104 cycles and stable memory retention performance up to 104 s, maintaining a high ION/IOFF ratio of 104 under a bending radius of 2.5 mm. Moreover, the device achieves a pattern recognition accuracy of 97.44%, enabled by highly symmetric analog switching with multilevel conductance states. These results highlight that hybrid metal-oxo clusters can provide novel material design principles for flexible and reliable neuromorphic applications, contributing to the development of artificial neural networks.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412289"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202413675

Hongli Zhou, Minyu Zhou, XiPing Liao, Liangyu Zhang, Hang Wei, Yuting Lu, Yiqing Zhang, Hui Huang, Yue Hu, Tao Chen, Zhiyue Lv

{"title":"The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes.","authors":"Hongli Zhou, Minyu Zhou, XiPing Liao, Liangyu Zhang, Hang Wei, Yuting Lu, Yiqing Zhang, Hui Huang, Yue Hu, Tao Chen, Zhiyue Lv","doi":"10.1002/advs.202413675","DOIUrl":"https://doi.org/10.1002/advs.202413675","url":null,"abstract":"Angiostrongylus cantonensis (AC) is the leading cause of eosinophilic meningoencephalitis worldwide. The neuroimmune interactions between peripheral and central immune systems in angiostrongyliasis remain unclear. In this study, significant infiltration of eosinophils, myeloid cells, macrophages, neutrophils, and Ly6C monocytes is observed in the brains of AC-infected mice, with macrophages being the most abundant. RNA-seq and SMART-seq analysis of pattern recognition receptor (PRR) and DNA sensor gene sets revealed a marked increase in Z-DNA binding protein 1 (Zbp1) expression in infected mice. Confocal microscopy, RT-qPCR, western blotting, and immunohistochemistry further confirmed that Zbp1 is specifically upregulated in macrophages and microglia. Using Zbp1-knockout mice and flow cytometry, it is found that knockout of Zbp1 enhanced lymphocyte infiltration and natural killer cell cytotoxicity, modulating the immune microenvironment in the central nervous system (CNS) during AC infection. Mechanistically, it is revealed that in macrophage Zbp1 directly binds to receptor-interacting protein 3 (RIP3) to promote its phosphorylation, subsequently facilitating the phosphorylation of mixed lineage kinase domain-like protein (Mlkl). The activated Zbp1-pRIP3-pMlkl axis leads to necroptosis and upregulates pro-inflammatory cytokines including TNF-α, IL-1α, CXCL9, CXCL10 in macrophages, which recruits and activates immune cells. These findings offer new insights into the pathogenic mechanisms of angiostrongyliasis and suggest potential therapeutic strategies.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413675"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202412667

Jun-Min Chen, Guang Shi, Lu-Lu Yu, Wei Shan, Jing-Yu Sun, An-Chen Guo, Jian-Ping Wu, Tie-Shan Tang, Xiang-Jian Zhang, Qun Wang

{"title":"3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes.","authors":"Jun-Min Chen, Guang Shi, Lu-Lu Yu, Wei Shan, Jing-Yu Sun, An-Chen Guo, Jian-Ping Wu, Tie-Shan Tang, Xiang-Jian Zhang, Qun Wang","doi":"10.1002/advs.202412667","DOIUrl":"https://doi.org/10.1002/advs.202412667","url":null,"abstract":"Ischemic stroke is the most common cerebrovascular disease and the leading cause of permanent disability worldwide. Recent studies have shown that stroke development and prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation of 3-hydroxy-kynurenamine (3-HKA) in stroke patients and animal models is identified. Supplementation with 3-HKA improved long-term neurological recovery, reduced infarct volume, and increased ipsilateral cerebral blood flow after distal middle cerebral artery occlusion (MCAO). 3-HKA promoted angiogenesis, functional blood vessel formation, and blood-brain barrier (BBB) repair. Moreover, 3-HKA inhibited A1-like (neurotoxic) astrocyte activation but promoted A2-like (neuroprotective) astrocyte polarization. Proteomic analysis revealed that 3-HKA inhibited AIM2 inflammasome activation after stroke, and co-labeling studies indicated that AIM2 expression typically increased in astrocytes at 7 and 14 days after stroke. Consistently, in co-cultures of primary mouse brain microvascular endothelial cells and astrocytes, 3-HKA promoted angiogenesis after oxygen-glucose deprivation (OGD). AIM2 overexpression in astrocytes abrogated 3-HKA-driven vascular remodeling in vitro and in vivo, suggesting that 3-HKA may regulate astrocyte-mediated vascular remodeling by impeding AIM2 inflammasome activation. In conclusion, 3-HKA may promote post-stroke vascular remodeling by regulating A1/A2 astrocyte activation, thereby improving long-term neurological recovery, suggesting that supplementation with 3-HKA may be an efficient therapy for stroke.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412667"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Cyclic O₆ Molecules Stabilized by Helium under Pressure.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202415517

Jingyu Hou, Qiang Zhu, Xiao-Ji Weng, Xi Shao, Xiao Dong, Hui-Tian Wang, Xiang-Feng Zhou, Yongjun Tian

{"title":"Prediction of Cyclic O6 Molecules Stabilized by Helium under Pressure.","authors":"Jingyu Hou, Qiang Zhu, Xiao-Ji Weng, Xi Shao, Xiao Dong, Hui-Tian Wang, Xiang-Feng Zhou, Yongjun Tian","doi":"10.1002/advs.202415517","DOIUrl":"https://doi.org/10.1002/advs.202415517","url":null,"abstract":"Oxygen usually exists in the form of diatomic molecules at ambient conditions. At high pressure, it undergoes a series of phase transitions from diatomic O2 to O8 cluster and ultimately dissociates into a polymeric O4 spiral chain structure. Intriguingly, the commonly found cyclic hexameric molecules in other group VIA elements (e.g., S6 and Se6) are never reported in the bulk oxygen. Through extensive computational crystal structure search, herein it is reported that such hexameric O6 molecules can exist in a stable compound HeO3 above 1.9 TPa. The first-principles calculations reveal that, during the reaction by mixing oxygen with helium, the insertion of helium does not only expand the lattice volume, but also relieves the electron lone pair repulsion among diatomic O2, and thus significantly promoting the formation of cyclic O6 molecules. Furthermore, the transition pathway calculations demonstrate that molecular O2 is dissociated first, and then six oxygen atoms form a polymeric digital 2-shaped intermediate O6. Subsequently, each unstable intermediate O6 decomposes into two intermedia O3 trimers. Finally, O3 trimers transform into cyclic O6 molecules at high pressure. This study expands the known molecular forms of oxygen and suggests a route to the synthesis of intriguing cyclic O6 molecules.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2415517"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine".

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202414927

引用次数: 0

Fabrication of Multifunctional Three-Component Supramolecular Nano-Biscuits via Two Macrocycles-Involved Self-Assembly for Rice, Citrus and Kiwifruit Protections.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-24 DOI: 10.1002/advs.202413826

Xinyu He, Jinghan Yang, Xue Chen, Jiajia Chen, Haicong Zhao, Juan Liu, Fengpei Du, Peiyi Wang

{"title":"Fabrication of Multifunctional Three-Component Supramolecular Nano-Biscuits via Two Macrocycles-Involved Self-Assembly for Rice, Citrus and Kiwifruit Protections.","authors":"Xinyu He, Jinghan Yang, Xue Chen, Jiajia Chen, Haicong Zhao, Juan Liu, Fengpei Du, Peiyi Wang","doi":"10.1002/advs.202413826","DOIUrl":"https://doi.org/10.1002/advs.202413826","url":null,"abstract":"Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three-component supramolecular nano-biscuits (NI6R@CB[7]@β-CD) are successfully engineered via ordered self-assembly between two macrocycles [cucurbit[7]uril (CB[7]), β-cyclodextrin (β-CD)] and (R)-2-naphthol-based bis-imidazolium bromide salt (NI6R). This macrocycles-involved bactericidal material combines many advantages. 1) Alleviate the off-target movement of droplets on hydrophobic blade surfaces. 2) Enhance the biofilm-disrupting ability. At a low-dose of 4.44 µg mL-1, the inhibition rate of biofilm formation reached 78.3%. At 35.5 µg mL-1, the potency to remove mature biofilms reached 77.6%. 3) Efficiently hinder bacterial reproduction, swimming, extracellular polysaccharide production, extracellular enzyme secretion, and virulence to plants. These superior characteristics are undoubtedly transmitted to the in vivo control effect. At 200 µg mL-1, this smart material exhibits superior control efficiencies of 49.6%/65.0%/85.4% against three kinds of bacterial diseases (rice leaf blight, citrus canker, and kiwifruit canker), respectively, surpassing the commercial bactericide-thiodiazole-copper-20%SC (33.6%/41.5%/43.2%) and NI6R (40.3%/51.2%/71.2%). Furthermore, NI6R@CB[7]@β-CD is biosafe to non-target organisms. This study is instructive for constructing multifunctional agrochemicals in sustainable crop protection.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413826"},"PeriodicalIF":14.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0